Retinal Capillary Vessel Density and Foveal Avascular Zone Size in Patients With Psoriatic Arthritis: A Case-Control Study. (PsA-RETINA)
Evaluation of Retinal Capillary Vascular Structures and the Foveal Avascular Zone in Patients With Psoriatic Arthritis.
In terms of blood flow per unit of tissue, the retina is one of the tissues with the highest blood flow in the body. Parameters such as the thickness of the choroid layer, which plays a crucial role in maintaining normal eye function, the dimensions of the foveal avascular zone (FAZ) supplied by this layer, and retinal vascular networks can be measured using non-invasive methods. OCTA (Optical Coherence Tomography Angiography) is an imaging tool that enables the non-invasive assessment of retinal microvascular densities and the measurement of the foveal avascular zone's dimensions. Studies conducted to date indicate that retinal capillary vessels and the dimensions of the foveal avascular zone are affected in rheumatological diseases, especially associated with systemic inflammation. This study aims to compare retinal capillary vessel density and foveal avascular zone dimensions in patients with psoriatic arthritis against those in a healthy population and in patients with psoriasis who do not have psoriatic arthritis, utilizing the non-invasive method of optical coherence tomography angiography.
研究概览
详细说明
In terms of blood flow per unit of tissue, the retina is one of the tissues with the highest blood flow in the body. Non-invasive methods allow for the measurement of-and the detection of changes in-the thickness of the choroid layer (which plays a crucial role in maintaining normal eye function), the foveal avascular zone (nourished by this layer), and the retinal vascular networks. OCTA (Optical Coherence Tomography Angiography) is an imaging tool capable of non-invasively assessing retinal microvascular densities and measuring the dimensions of the foveal avascular zone. Retinal microvascular structures can be affected by systemic pathologies, including various eye diseases. In recent years, there has been growing evidence indicating that retinal vessel densities-as detected by OCTA-are significantly altered and the dimensions of the foveal avascular zone differ in patients with connective tissue diseases, vasculitis, and spondylitis. Psoriatic arthritis is a common chronic inflammatory disease characterized by both spondyloarthropathy and peripheral arthritis involvement. There is currently no data in the literature regarding the status of the choroidal vasculature-a highly perfused tissue-in patients with psoriatic arthritis or its relationship with disease activity. In this study, we aimed to compare retinal capillary density and foveal avascular zone dimensions among patients with psoriatic arthritis, patients with psoriasis, and healthy individuals using OCTA. The study will also compare findings between subgroups of psoriatic patients with and without concomitant spondylitis.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Koray Ayar, Associated Proffessor
- 电话号码：1648 +90 224-2955000
- 邮箱：ayarkoray@hotmail.com
学习地点
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Yıldırım
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Bursa、Yıldırım、土耳其（türkiye）、16130
- 招聘中
- University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital
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接触：
- Koray Ayar
- 电话号码：05325618450
- 邮箱：ayarkoray@hotmail.com
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接触：
- Koray Ayar, Associated Proffessor (Dr.)
- 电话号码：1648 +90 224-2955000
- 邮箱：ayarkoray@hotmail.com
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首席研究员：
- Koray Ayar, Associated Proffessor (Dr.)
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副研究员：
- Neslihan Parmak Yener, Associated Proffessor
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
The study population consists of volunteers from among patients with psoriatic arthritis who are being followed at the study center's rheumatology clinic. The patient control group comprises volunteers diagnosed with psoriasis by a specialist dermatologist. Participants in the healthy control group are healthcare workers or patient companions matched for age and gender with the patient group and the patient control group.
描述
Inclusion Criteria:
- Volunteers diagnosed with psoriatic arthritis according to CASPAR criteria
- Volunteers diagnosed with psoriasis by a specialist dermatologist
- Hospital staff or patient companions with no chronic illnesses
Exclusion Criteria:
- Diabetes mellitus
- Cancer
- Pregnancy or lactation
- Chronic renal failure
- Glocome
- History of eye surgery
- History of eye trauma
学习计划
研究是如何设计的？
设计细节
- 观测模型：CASE_CONTROL
- 时间观点：PROSPECTIVE
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
Psoriatic arthritis
Participants with psoriatic arthritis |
Vessel density of retinal superficial capillary plexus Vessel density of retinal deep capillary plexus Vessel density of retinal prepapillary capillaries FAZ essessment parameters |
|
Psoriasis
Psoriasis participants with no other known systemic inflammatory disease |
Vessel density of retinal superficial capillary plexus Vessel density of retinal deep capillary plexus Vessel density of retinal prepapillary capillaries FAZ essessment parameters |
|
Healthy controls
Patient companions or hospital staff with no known chronic illnesses |
Vessel density of retinal superficial capillary plexus Vessel density of retinal deep capillary plexus Vessel density of retinal prepapillary capillaries FAZ essessment parameters |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Retinal SCP, VD
大体时间：1 day
|
Vessel density of retinal superficial capillary plexus |
1 day
|
|
Retinal DCP, VD
大体时间：1 day
|
Vessel density of retinal deep capillary plexus |
1 day
|
|
Retinal RCP, VD
大体时间：1 day
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Vessel density of retinal prepapillary capillaries |
1 day
|
|
FAZ parameters
大体时间：1 day
|
Foveal avasculary assessment parameters |
1 day
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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