이 페이지는 자동 번역되었으며 번역의 정확성을 보장하지 않습니다. 참조하십시오 영문판 원본 텍스트의 경우.

재발성 또는 전이성 두경부 편평 세포 암종 환자 치료에서 베바시주맙을 포함하거나 포함하지 않는 화학 요법

2026년 10월 21일 업데이트: National Cancer Institute (NCI)

재발성 또는 전이성 두경부암 환자에서 베바시주맙을 병용하거나 병용하지 않는 화학 요법의 III상 무작위 시험

This randomized phase III trial studies chemotherapy to see how well it works with or without bevacizumab in treating patients with head and neck squamous cell carcinoma that has come back (recurrent) or that has spread to other parts of the body (metastatic). Drugs used in chemotherapy, such as docetaxel, cisplatin, carboplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Bevacizumab may also make tumor cells more sensitive to chemotherapy and stop the growth of head and neck cancer by blocking blood flow to the tumor. It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab in treating patients with head and neck squamous cell carcinoma.

연구 개요

상태

모집하지 않고 적극적으로

정황

개입 / 치료

상세 설명

PRIMARY OBJECTIVES:

I. To compare the overall survival of patients with recurrent or metastatic head and neck cancer treated with standard platinum-based chemotherapy with or without bevacizumab.

SECONDARY OBJECTIVES:

I. To assess toxicities with the addition of bevacizumab to each platinum-doublet (cisplatin/docetaxel, carboplatin/docetaxel, cisplatin/fluorouracil [5-FU], carboplatin/5-FU).

II. To compare the objective response rates and the progression-free survival achieved with the above therapies.

III. To collect blood samples before and after therapy for future correlative studies.

IV. To collect tumor tissue samples available at baseline from prior diagnostic procedures for future correlative studies.

OUTLINE: After the physician decides which chemotherapy doublet to use, patients are randomized to 1 of 2 treatment arms for that chemotherapy combination.

ARM IA: Patients receive chemotherapy comprising docetaxel intravenously (IV) over 1 hour and cisplatin IV over 1-2 hours on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IB: Patients receive bevacizumab IV over 30-90 minutes on day 1 and docetaxel and cisplatin as in Arm IA.

ARM IIA: Patients receive docetaxel IV over 1 hour and carboplatin IV over 30 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IIB: Patients receive bevacizumab as in arm IB and docetaxel and carboplatin as in Arm IIA.

ARM IIIA: Patients receive cisplatin IV over 1-2 hours on day 1 and fluorouracil IV continuously on days 1-4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IIIB: Patients receive bevacizumab as in Arm IB and cisplatin and fluorouracil as in Arm IIIA.

ARM IVA: Patients receive carboplatin IV over 30 minutes on day 1 and fluorouracil IV continuously on days 1-4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IVB: Patients receive bevacizumab as in Arm IB and carboplatin and fluorouracil as in Arm IVA.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

연구 유형

중재적

등록 (실제)

403

단계

  • 3단계

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  • 남아프리카
      • Pretoria, 남아프리카, 0002
        • University Of Pretoria
  • 미국
    • Alabama
      • Mobile, Alabama, 미국, 36688
        • University of South Alabama Mitchell Cancer Institute
      • Mobile, Alabama, 미국, 36608
        • Providence Hospital
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      • Fairbanks, Alaska, 미국, 99701
        • Fairbanks Memorial Hospital
    • Arkansas
      • Fort Smith, Arkansas, 미국, 72903
        • Mercy Hospital Fort Smith
      • Jonesboro, Arkansas, 미국, 72401
        • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
      • Little Rock, Arkansas, 미국, 72205
        • University of Arkansas for Medical Sciences
      • Little Rock, Arkansas, 미국, 72205
        • John L McClellan Memorial Veterans Hospital
    • California
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        • Kaiser Permanente-Anaheim
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        • Kaiser Permanente-Bellflower
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        • Alta Bates Summit Medical Center-Herrick Campus
      • Burlingame, California, 미국, 94010
        • Mills-Peninsula Medical Center
      • Castro Valley, California, 미국, 94546
        • Eden Hospital Medical Center
      • Castro Valley, California, 미국, 94546
        • East Bay Radiation Oncology Center
      • Castro Valley, California, 미국, 94546
        • Valley Medical Oncology Consultants-Castro Valley
      • Dublin, California, 미국, 94568
        • Epic Care-Dublin
      • Emeryville, California, 미국, 94608
        • Bay Area Breast Surgeons Inc
      • Emeryville, California, 미국, 94608
        • Epic Care Partners in Cancer Care
      • Fontana, California, 미국, 92335
        • Kaiser Permanente-Fontana
      • Fremont, California, 미국, 94538
        • Valley Medical Oncology Consultants-Fremont
      • Harbor City, California, 미국, 90710
        • Kaiser Permanente South Bay
      • Irvine, California, 미국, 92618
        • Kaiser Permanente-Irvine
      • La Jolla, California, 미국, 92093
        • UC San Diego Moores Cancer Center
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        • Kaiser Permanente Los Angeles Medical Center
      • Los Angeles, California, 미국, 90034
        • Kaiser Permanente West Los Angeles
      • Martinez, California, 미국, 94553-3156
        • Contra Costa Regional Medical Center
      • Modesto, California, 미국, 95355
        • Memorial Medical Center
      • Mountain View, California, 미국, 94040
        • El Camino Hospital
      • Novato, California, 미국, 94945
        • Sutter Cancer Research Consortium
      • Oakland, California, 미국, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, 미국, 94609
        • Hematology and Oncology Associates-Oakland
      • Oakland, California, 미국, 94609
        • Tom K Lee Inc
      • Oakland, California, 미국, 94609
        • Bay Area Tumor Institute
      • Oakland, California, 미국, 94602
        • Wilma Chan Highland Hospital
      • Palo Alto, California, 미국, 94304
        • VA Palo Alto Health Care System
      • Palo Alto, California, 미국, 94304
        • Stanford Cancer Institute Palo Alto
      • Panorama City, California, 미국, 91402
        • Kaiser Permanente - Panorama City
      • Pleasanton, California, 미국, 94588
        • Valley Care Health System - Pleasanton
      • Pleasanton, California, 미국, 94588
        • Valley Medical Oncology Consultants
      • Riverside, California, 미국, 92505
        • Kaiser Permanente-Riverside
      • San Diego, California, 미국, 92120
        • Kaiser Permanente-San Diego Zion
      • San Diego, California, 미국, 92161
        • San Diego VA Medical Center
      • San Diego, California, 미국, 92108
        • Kaiser Permanente-Rio San Diego
      • San Francisco, California, 미국, 94115
        • California Pacific Medical Center-Pacific Campus
      • San Marcos, California, 미국, 92078
        • Kaiser Permanente-San Marcos
      • San Pablo, California, 미국, 94806
        • Doctors Medical Center- JC Robinson Regional Cancer Center
      • Santa Rosa, California, 미국, 95403
        • Sutter Pacific Medical Foundation
      • St. Helena, California, 미국, 94574
        • Saint Helena Hospital
      • Vallejo, California, 미국, 94589
        • Sutter Solano Medical Center/Cancer Center
      • Woodland Hills, California, 미국, 91367
        • Kaiser Permanente-Woodland Hills
    • Colorado
      • Aurora, Colorado, 미국, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Aurora, Colorado, 미국, 80012
        • The Medical Center of Aurora
      • Boulder, Colorado, 미국, 80303
        • Boulder Community Foothills Hospital
      • Boulder, Colorado, 미국, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Colorado Springs, Colorado, 미국, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, 미국, 80907
        • Rocky Mountain Cancer Centers-Penrose
      • Denver, Colorado, 미국, 80205
        • Kaiser Permanente-Franklin
      • Denver, Colorado, 미국, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, 미국, 80220
        • Rose Medical Center
      • Denver, Colorado, 미국, 80218
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, 미국, 80220
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, 미국, 80218
        • Colorado Blood Cancer Institute
      • Denver, Colorado, 미국, 80222
        • Western States Cancer Research NCORP
      • Denver, Colorado, 미국, 80218
        • Saint Joseph Hospital - Cancer Centers of Colorado
      • Denver, Colorado, 미국, 80210
        • AdventHealth Porter
      • Durango, Colorado, 미국, 81301
        • Mercy Medical Center
      • Durango, Colorado, 미국, 81301
        • CommonSpirit Cancer Center Mercy
      • Englewood, Colorado, 미국, 80113
        • Mountain Blue Cancer Care Center - Swedish
      • Englewood, Colorado, 미국, 80113
        • Swedish Medical Center
      • Fort Collins, Colorado, 미국, 80524
        • Poudre Valley Hospital
      • Golden, Colorado, 미국, 80401
        • Mountain Blue Cancer Care Center
      • Grand Junction, Colorado, 미국, 81501
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, 미국, 80631
        • Banner North Colorado Medical Center
      • Greenwood Village, Colorado, 미국, 80111
        • Rocky Mountain Cancer Centers-Greenwood Village
      • Lafayette, Colorado, 미국, 80026
        • Kaiser Permanente-Rock Creek
      • Lakewood, Colorado, 미국, 80228
        • Rocky Mountain Cancer Centers-Lakewood
      • Lakewood, Colorado, 미국, 80228
        • CommonSpirit Saint Anthony Hospital Cancer Center
      • Littleton, Colorado, 미국, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Littleton, Colorado, 미국, 80122
        • AdventHealth Littleton
      • Lone Tree, Colorado, 미국, 80124
        • Kaiser Permanente-Lone Tree
      • Lone Tree, Colorado, 미국, 80124
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, 미국, 80124
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Longmont, Colorado, 미국, 80501
        • Longmont United Hospital
      • Longmont, Colorado, 미국, 80501
        • Rocky Mountain Cancer Centers-Longmont
      • Loveland, Colorado, 미국, 80539
        • Banner North Colorado Medical Center - Loveland Campus
      • Parker, Colorado, 미국, 80138
        • Rocky Mountain Cancer Centers-Parker
      • Parker, Colorado, 미국, 80138
        • AdventHealth Parker
      • Pueblo, Colorado, 미국, 81004
        • Saint Mary Corwin Medical Center
      • Pueblo, Colorado, 미국, 81008
        • Rocky Mountain Cancer Centers - Pueblo
      • Thornton, Colorado, 미국, 80260
        • Rocky Mountain Cancer Centers-Thornton
      • Thornton, Colorado, 미국, 80229
        • North Suburban Medical Center
      • Wheat Ridge, Colorado, 미국, 80401
        • Intermountain Health Lutheran Hospital
    • Connecticut
      • Farmington, Connecticut, 미국, 06030
        • University of Connecticut
      • Hartford, Connecticut, 미국, 06105
        • Smilow Cancer Hospital Care Center at Saint Francis
      • New Britain, Connecticut, 미국, 06050
        • The Hospital of Central Connecticut
      • New Haven, Connecticut, 미국, 06520
        • Yale University
      • Norwich, Connecticut, 미국, 06360
        • Eastern Connecticut Hematology and Oncology Associates
    • Delaware
      • Dover, Delaware, 미국, 19901
        • Bayhealth Hospital Kent Campus
      • Lewes, Delaware, 미국, 19958
        • Beebe Medical Center
      • Newark, Delaware, 미국, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, 미국, 19713
        • Delaware Clinical and Laboratory Physicians PA
      • Newark, Delaware, 미국, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, 미국, 19718
        • Christiana Care Health System-Christiana Hospital
      • Rehoboth Beach, Delaware, 미국, 19971
        • Beebe Health Campus
      • Seaford, Delaware, 미국, 19973
        • TidalHealth Nanticoke / Allen Cancer Center
      • Wilmington, Delaware, 미국, 19801
        • Christiana Care Health System-Wilmington Hospital
    • District of Columbia
      • Washington D.C., District of Columbia, 미국, 20037
        • George Washington University Medical Center
      • Washington D.C., District of Columbia, 미국, 20007
        • MedStar Georgetown University Hospital
    • Florida
      • Boca Raton, Florida, 미국, 33486
        • Boca Raton Regional Hospital
      • Fort Lauderdale, Florida, 미국, 33316
        • Broward Health Medical Center
      • Fort Lauderdale, Florida, 미국, 33308
        • Holy Cross Hospital
      • Gainesville, Florida, 미국, 32605
        • Florida Cancer Specialists-Gainesville Cancer Center
      • Gainesville, Florida, 미국, 32610
        • UF Health Cancer Institute - Gainesville
      • Hollywood, Florida, 미국, 33021
        • Memorial Regional Hospital/Joe DiMaggio Children's Hospital
      • Jacksonville, Florida, 미국, 32207
        • Baptist MD Anderson Cancer Center
      • Jupiter, Florida, 미국, 33458
        • Jupiter Medical Center
      • Miami, Florida, 미국, 33136
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
      • Miami Beach, Florida, 미국, 33140
        • Mount Sinai Medical Center
      • Pembroke Pines, Florida, 미국, 33028
        • Memorial Hospital West
      • Pensacola, Florida, 미국, 32504
        • Sacred Heart Hospital
      • Titusville, Florida, 미국, 32796
        • Space Coast Cancer Centers-Titusville
      • Weston, Florida, 미국, 33331
        • Cleveland Clinic-Weston
    • Georgia
      • Atlanta, Georgia, 미국, 30308
        • Emory University Hospital Midtown
      • Atlanta, Georgia, 미국, 30322
        • Emory University Hospital/Winship Cancer Institute
      • Atlanta, Georgia, 미국, 30342
        • Emory Saint Joseph's Hospital
      • Atlanta, Georgia, 미국, 30309
        • Piedmont Hospital
      • Atlanta, Georgia, 미국, 30342
        • Northside Hospital
      • Atlanta, Georgia, 미국, 30342
        • Atlanta Regional CCOP
      • Austell, Georgia, 미국, 30106
        • WellStar Cobb Hospital
      • Columbus, Georgia, 미국, 31904
        • John B Amos Cancer Center
      • Decatur, Georgia, 미국, 30033
        • Atlanta VA Medical Center
      • Decatur, Georgia, 미국, 30033
        • Emory Decatur Hospital
      • Fayetteville, Georgia, 미국, 30214
        • Piedmont Fayette Hospital
      • Gainesville, Georgia, 미국, 30501
        • Northeast Georgia Medical Center-Gainesville
      • Lawrenceville, Georgia, 미국, 30046
        • Northside Hospital - Gwinnett
      • Marietta, Georgia, 미국, 30060
        • Wellstar Kennestone Hospital
      • Riverdale, Georgia, 미국, 30274
        • Southern Regional Medical Center
      • Rome, Georgia, 미국, 30165
        • Harbin Clinic Medical Oncology and Clinical Research
      • Savannah, Georgia, 미국, 31404
        • Memorial Health University Medical Center
      • Savannah, Georgia, 미국, 31404
        • Summit Cancer Care-Memorial
      • Savannah, Georgia, 미국, 31404
        • Low Country Cancer Care
    • Hawaii
      • Honolulu, Hawaii, 미국, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, 미국, 96817
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, 미국, 96813
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, 미국, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, 미국, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, 미국, 96817
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, 미국, 96826
        • Kapiolani Medical Center for Women and Children
      • Wailuku, Hawaii, 미국, 96793
        • Maui Memorial Medical Center
      • Wailuku, Hawaii, 미국, 96793
        • Pacific Cancer Institute of Maui
      • ‘Aiea, Hawaii, 미국, 96701
        • Pali Momi Medical Center
    • Idaho
      • Boise, Idaho, 미국, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Boise, Idaho, 미국, 83712
        • Saint Luke's Cancer Institute - Boise
      • Fruitland, Idaho, 미국, 83619
        • Saint Luke's Cancer Institute - Fruitland
      • Meridian, Idaho, 미국, 83642
        • Saint Luke's Cancer Institute - Meridian
      • Nampa, Idaho, 미국, 83687
        • Saint Luke's Cancer Institute - Nampa
      • Post Falls, Idaho, 미국, 83854
        • Kootenai Clinic Cancer Services - Post Falls
      • Twin Falls, Idaho, 미국, 83301
        • Saint Luke's Cancer Institute - Twin Falls
    • Illinois
      • Aurora, Illinois, 미국, 60504
        • Rush-Copley Medical Center
      • Berwyn, Illinois, 미국, 60402
        • Mac Neal Hospital
      • Bloomington, Illinois, 미국, 61704
        • Illinois CancerCare-Bloomington
      • Bloomington, Illinois, 미국, 61701
        • OSF Saint Joseph Medical Center
      • Canton, Illinois, 미국, 61520
        • Illinois CancerCare-Canton
      • Canton, Illinois, 미국, 61520
        • Graham Hospital Association
      • Carbondale, Illinois, 미국, 62902
        • Memorial Hospital of Carbondale
      • Carthage, Illinois, 미국, 62321
        • Illinois CancerCare-Carthage
      • Carthage, Illinois, 미국, 62321
        • Memorial Hospital
      • Centralia, Illinois, 미국, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, 미국, 60611
        • Northwestern University
      • Chicago, Illinois, 미국, 60612
        • University of Illinois
      • Chicago, Illinois, 미국, 60612
        • John H Stroger Jr Hospital of Cook County
      • Chicago, Illinois, 미국, 60657
        • UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
      • Chicago, Illinois, 미국, 60608
        • Mount Sinai Hospital Medical Center
      • Chicago, Illinois, 미국, 60611
        • Hematology and Oncology Associates
      • Chicago, Illinois, 미국, 60631
        • Presence Resurrection Medical Center
      • Chicago, Illinois, 미국, 60640
        • Weiss Memorial Hospital
      • Danville, Illinois, 미국, 61832
        • Carle at The Riverfront
      • Decatur, Illinois, 미국, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, 미국, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Decatur, Illinois, 미국, 62526
        • Heartland Cancer Research NCORP
      • Downers Grove, Illinois, 미국, 60515
        • Advocate Good Samaritan Hospital
      • Effingham, Illinois, 미국, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, 미국, 62401
        • Carle Physician Group-Effingham
      • Elmhurst, Illinois, 미국, 60126
        • Elmhurst Memorial Hospital
      • Eureka, Illinois, 미국, 61530
        • Illinois CancerCare-Eureka
      • Eureka, Illinois, 미국, 61530
        • Eureka Hospital
      • Evanston, Illinois, 미국, 60201
        • NorthShore University HealthSystem-Evanston Hospital
      • Galesburg, Illinois, 미국, 61401
        • Western Illinois Cancer Treatment Center
      • Galesburg, Illinois, 미국, 61401
        • Illinois CancerCare-Galesburg
      • Galesburg, Illinois, 미국, 61401
        • Galesburg Cottage Hospital
      • Glenview, Illinois, 미국, 60026
        • NorthShore University HealthSystem-Glenbrook Hospital
      • Harvey, Illinois, 미국, 60426
        • Ingalls Memorial Hospital
      • Havana, Illinois, 미국, 62644
        • Mason District Hospital
      • Havana, Illinois, 미국, 62644
        • Illinois CancerCare-Havana
      • Highland Park, Illinois, 미국, 60035
        • NorthShore University HealthSystem-Highland Park Hospital
      • Highland Park, Illinois, 미국, 60035
        • Hematology Oncology Associates of Illinois-Highland Park
      • Hinsdale, Illinois, 미국, 60521
        • Hinsdale Hematology Oncology Associates Incorporated
      • Hopedale, Illinois, 미국, 61747
        • Hopedale Medical Complex - Hospital
      • Joliet, Illinois, 미국, 60435
        • Duly Health and Care Joliet
      • Joliet, Illinois, 미국, 60432
        • Midwest Center for Hematology Oncology
      • Kankakee, Illinois, 미국, 60901
        • Presence Saint Mary's Hospital
      • Kewanee, Illinois, 미국, 61443
        • Illinois CancerCare-Kewanee Clinic
      • La Grange, Illinois, 미국, 60525
        • AMITA Health Adventist Medical Center
      • Libertyville, Illinois, 미국, 60048
        • AMG Libertyville - Oncology
      • Macomb, Illinois, 미국, 61455
        • Illinois CancerCare-Macomb
      • Macomb, Illinois, 미국, 61455
        • Mcdonough District Hospital
      • Mattoon, Illinois, 미국, 61938
        • Carle Physician Group-Mattoon/Charleston
      • Maywood, Illinois, 미국, 60153
        • Loyola University Medical Center
      • Moline, Illinois, 미국, 61265
        • Garneau, Stewart C MD (UIA Investigator)
      • Moline, Illinois, 미국, 61265
        • Porubcin, Michael MD (UIA Investigator)
      • Moline, Illinois, 미국, 61265
        • Spector, David MD (UIA Investigator)
      • Moline, Illinois, 미국, 61265
        • Trinity Medical Center
      • Monmouth, Illinois, 미국, 61462
        • Illinois CancerCare-Monmouth
      • Monmouth, Illinois, 미국, 61462
        • Holy Family Medical Center
      • Mount Vernon, Illinois, 미국, 62864
        • SSM Health Good Samaritan
      • Niles, Illinois, 미국, 60714
        • Illinois Cancer Specialists-Niles
      • Normal, Illinois, 미국, 61761
        • Carle Cancer Institute Normal
      • Normal, Illinois, 미국, 61761
        • Illinois CancerCare-Community Cancer Center
      • Normal, Illinois, 미국, 61761
        • Carle BroMenn Medical Center
      • Ottawa, Illinois, 미국, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Ottawa, Illinois, 미국, 61350
        • Radiation Oncology of Northern Illinois
      • Ottawa, Illinois, 미국, 61350
        • Ottawa Regional Hospital and Healthcare Center
      • Pekin, Illinois, 미국, 61554
        • Illinois CancerCare-Pekin
      • Pekin, Illinois, 미국, 61554
        • Pekin Hospital
      • Pekin, Illinois, 미국, 61554
        • OSF Saint Francis Radiation Oncology at Pekin
      • Peoria, Illinois, 미국, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, 미국, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, 미국, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, 미국, 61615
        • OSF Saint Francis Radiation Oncology at Peoria Cancer Center
      • Peoria, Illinois, 미국, 61614
        • Proctor Hospital
      • Peru, Illinois, 미국, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, 미국, 61354
        • Valley Radiation Oncology
      • Peru, Illinois, 미국, 61354
        • Illinois Valley Hospital
      • Princeton, Illinois, 미국, 61356
        • Illinois CancerCare-Princeton
      • Princeton, Illinois, 미국, 61356
        • Perry Memorial Hospital
      • River Forest, Illinois, 미국, 60305
        • West Suburban Medical Center
      • Rockford, Illinois, 미국, 61104
        • Swedish American Hospital
      • Rockford, Illinois, 미국, 61114
        • UW Health Carbone Cancer Center Rockford
      • Skokie, Illinois, 미국, 60076
        • Hematology Oncology Associates of Illinois - Skokie
      • Spring Valley, Illinois, 미국, 61362
        • Saint Margaret's Hospital
      • Spring Valley, Illinois, 미국, 61362
        • Illinois CancerCare-Spring Valley
      • Springfield, Illinois, 미국, 62702
        • Central Illinois Hematology Oncology Center
      • Springfield, Illinois, 미국, 62781
        • Springfield Memorial Hospital
      • Urbana, Illinois, 미국, 61801
        • Carle Cancer Center
      • Urbana, Illinois, 미국, 61801
        • The Carle Foundation Hospital
      • Yorkville, Illinois, 미국, 60560
        • Rush-Copley Healthcare Center
    • Indiana
      • Elkhart, Indiana, 미국, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, 미국, 46514
        • Michiana Hematology Oncology PC-Elkhart
      • Elkhart, Indiana, 미국, 46514-2098
        • Elkhart Clinic
      • Fort Wayne, Indiana, 미국, 46845
        • Fort Wayne Medical Oncology and Hematology Inc-Parkview
      • Indianapolis, Indiana, 미국, 46260
        • Ascension Saint Vincent Indianapolis Hospital
      • Indianapolis, Indiana, 미국, 46202
        • Sidney and Lois Eskenazi Hospital
      • Kokomo, Indiana, 미국, 46904
        • Community Howard Regional Health
      • La Porte, Indiana, 미국, 46350
        • IU Health La Porte Hospital
      • Lafayette, Indiana, 미국, 47904
        • IU Health Arnett Cancer Care
      • Michigan City, Indiana, 미국, 46360
        • Franciscan Saint Anthony Health-Michigan City
      • Michigan City, Indiana, 미국, 46360
        • Woodland Cancer Care Center
      • Mishawaka, Indiana, 미국, 46545
        • Memorial Regional Cancer Center Day Road
      • Mishawaka, Indiana, 미국, 46545
        • Michiana Hematology Oncology PC-Mishawaka
      • Mishawaka, Indiana, 미국, 46545
        • Cancer Care Partners LLC
      • Mishawaka, Indiana, 미국, 46545
        • Saint Joseph Regional Medical Center-Mishawaka
      • Muncie, Indiana, 미국, 47303
        • IU Health Ball Memorial Hospital
      • Plymouth, Indiana, 미국, 46563
        • Michiana Hematology Oncology PC-Plymouth
      • South Bend, Indiana, 미국, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, 미국, 46628
        • Northern Indiana Cancer Research Consortium
      • South Bend, Indiana, 미국, 46617
        • South Bend Clinic
      • Westville, Indiana, 미국, 46391
        • Michiana Hematology Oncology PC-Westville
    • Iowa
      • Ames, Iowa, 미국, 50010
        • Mary Greeley Medical Center
      • Ames, Iowa, 미국, 50010
        • McFarland Clinic - Ames
      • Bettendorf, Iowa, 미국, 52722
        • Constantinou, Costas L MD (UIA Investigator)
      • Bettendorf, Iowa, 미국, 52722
        • University of Iowa Healthcare Cancer Services Quad Cities
      • Boone, Iowa, 미국, 50036
        • McFarland Clinic - Boone
      • Cedar Rapids, Iowa, 미국, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, 미국, 52403
        • Oncology Associates at Mercy Medical Center
      • Clive, Iowa, 미국, 50325
        • Mercy Cancer Center-West Lakes
      • Clive, Iowa, 미국, 50325
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
      • Council Bluffs, Iowa, 미국, 51503
        • Alegent Health Mercy Hospital
      • Des Moines, Iowa, 미국, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, 미국, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, 미국, 50316
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, 미국, 50309
        • Iowa-Wide Oncology Research Coalition NCORP
      • Des Moines, Iowa, 미국, 50307
        • Mercy Capitol
      • Des Moines, Iowa, 미국, 50309
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
      • Des Moines, Iowa, 미국, 50314
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
      • Fort Dodge, Iowa, 미국, 50501
        • McFarland Clinic - Trinity Cancer Center
      • Iowa City, Iowa, 미국, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • Jefferson, Iowa, 미국, 50129
        • McFarland Clinic - Jefferson
      • Marshalltown, Iowa, 미국, 50158
        • McFarland Clinic - Marshalltown
      • Mason City, Iowa, 미국, 50401
        • Mercy Medical Center - North Iowa
      • Ottumwa, Iowa, 미국, 52501
        • Ottumwa Regional Health Center
      • Sioux City, Iowa, 미국, 51101
        • Siouxland Regional Cancer Center
      • Sioux City, Iowa, 미국, 51102
        • Mercy Medical Center-Sioux City
      • Sioux City, Iowa, 미국, 51104
        • Saint Luke's Regional Medical Center
      • West Des Moines, Iowa, 미국, 50266-7700
        • Methodist West Hospital
      • West Des Moines, Iowa, 미국, 50266
        • Mercy Medical Center-West Lakes
    • Kansas
      • Chanute, Kansas, 미국, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, 미국, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, 미국, 67042
        • Cancer Center of Kansas - El Dorado
      • Fort Scott, Kansas, 미국, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, 미국, 67301
        • Cancer Center of Kansas-Independence
      • Kansas City, Kansas, 미국, 66112
        • Providence Medical Center
      • Kingman, Kansas, 미국, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, 미국, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, 미국, 67905
        • Cancer Center of Kansas-Liberal
      • Manhattan, Kansas, 미국, 66502
        • Cancer Center of Kansas-Manhattan
      • McPherson, Kansas, 미국, 67460
        • Cancer Center of Kansas - McPherson
      • Newton, Kansas, 미국, 67114
        • Cancer Center of Kansas - Newton
      • Overland Park, Kansas, 미국, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, 미국, 66213
        • Saint Luke's South Hospital
      • Parsons, Kansas, 미국, 67357
        • Cancer Center of Kansas - Parsons
      • Prairie Village, Kansas, 미국, 66208
        • Kansas City NCI Community Oncology Research Program
      • Pratt, Kansas, 미국, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, 미국, 67401
        • Cancer Center of Kansas - Salina
      • Shawnee Mission, Kansas, 미국, 66204
        • AdventHealth Shawnee Mission
      • Wellington, Kansas, 미국, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, 미국, 67214
        • Ascension Via Christi Hospitals Wichita
      • Wichita, Kansas, 미국, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, 미국, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, 미국, 67208
        • Associates In Womens Health
      • Wichita, Kansas, 미국, 67214
        • Wichita NCI Community Oncology Research Program
      • Wichita, Kansas, 미국, 67214
        • Wesley Medical Center
      • Winfield, Kansas, 미국, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Ashland, Kentucky, 미국, 41101
        • Our Lady Bellefonte Hospital
      • Bardstown, Kentucky, 미국, 40004
        • CommonSpirit Saint Joseph Hospital - Bardstown
      • Corbin, Kentucky, 미국, 40701
        • Commonwealth Cancer Center-Corbin
      • Lexington, Kentucky, 미국, 40536
        • University of Kentucky/Markey Cancer Center
      • Lexington, Kentucky, 미국, 40504
        • Saint Joseph Radiation Oncology Resource Center
      • Lexington, Kentucky, 미국, 40509
        • CommonSpirit Saint Joseph Medical Center - East Lexington
      • Louisville, Kentucky, 미국, 40202
        • Jewish Hospital
      • Louisville, Kentucky, 미국, 40245
        • UofL Health Medical Center Northeast
      • Louisville, Kentucky, 미국, 40215
        • Saints Mary and Elizabeth Hospital
      • Shepherdsville, Kentucky, 미국, 40165
        • Jewish Hospital Medical Center South
    • Louisiana
      • Baton Rouge, Louisiana, 미국, 70809
        • Mary Bird Perkins Cancer Center
      • Baton Rouge, Louisiana, 미국, 70806
        • Baton Rouge General Medical Center
      • Baton Rouge, Louisiana, 미국, 70809
        • Hematology/Oncology Clinic PLLC
      • Marrero, Louisiana, 미국, 70072
        • West Jefferson Medical Center
      • Metairie, Louisiana, 미국, 70006
        • Robert Veith MD LLC
      • Monroe, Louisiana, 미국, 71202
        • Ochsner LSU Health Monroe Medical Center
      • New Orleans, Louisiana, 미국, 70112
        • Tulane University School of Medicine
      • New Orleans, Louisiana, 미국, 70112
        • University Medical Center New Orleans
      • New Orleans, Louisiana, 미국, 70112
        • Louisiana State University Health Science Center
      • Shreveport, Louisiana, 미국, 71103
        • LSU Health Sciences Center at Shreveport
      • Shreveport, Louisiana, 미국, 71105
        • Highland Clinic
    • Maine
      • Augusta, Maine, 미국, 04330
        • Harold Alfond Center for Cancer Care
      • Bangor, Maine, 미국, 04401
        • Eastern Maine Medical Center
    • Maryland
      • Baltimore, Maryland, 미국, 21287
        • Johns Hopkins University/Sidney Kimmel Cancer Center
      • Baltimore, Maryland, 미국, 21204
        • Greater Baltimore Medical Center
      • Elkton, Maryland, 미국, 21921
        • Christiana Care - Union Hospital
      • Frederick, Maryland, 미국, 21701
        • Frederick Memorial Hospital
    • Massachusetts
      • Attleboro, Massachusetts, 미국, 02703
        • Sturdy Memorial Hospital
      • Beverly, Massachusetts, 미국, 01915
        • Beverly Hospital
      • Boston, Massachusetts, 미국, 02111
        • Tufts Medical Center
      • Boston, Massachusetts, 미국, 02118
        • Boston Medical Center
      • Gloucester, Massachusetts, 미국, 01930
        • Addison Gilbert Hospital
      • Methuen, Massachusetts, 미국, 01844
        • Holy Family Hospital
      • Pittsfield, Massachusetts, 미국, 01201
        • Berkshire Medical Center - Cancer Center
      • Springfield, Massachusetts, 미국, 01199
        • Baystate Medical Center
    • Michigan
      • Ann Arbor, Michigan, 미국, 48106
        • Michigan Cancer Research Consortium NCORP
      • Ann Arbor, Michigan, 미국, 48109
        • University of Michigan Rogel Cancer Center
      • Ann Arbor, Michigan, 미국, 48106
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
      • Battle Creek, Michigan, 미국, 49017
        • Bronson Battle Creek
      • Big Rapids, Michigan, 미국, 49307
        • Spectrum Health Big Rapids Hospital
      • Dearborn, Michigan, 미국, 48124
        • Corewell Health Dearborn Hospital
      • Detroit, Michigan, 미국, 48236
        • Henry Ford Health Saint John Hospital
      • Escanaba, Michigan, 미국, 49829
        • OSF Saint Francis Hospital and Medical Group
      • Farmington Hills, Michigan, 미국, 48336
        • Corewell Health Farmington Hills Hospital
      • Flint, Michigan, 미국, 48532
        • Genesys Regional Medical Center-West Flint Campus
      • Flint, Michigan, 미국, 48503
        • Hurley Medical Center
      • Flint, Michigan, 미국, 48503
        • Genesys Hurley Cancer Institute
      • Grand Rapids, Michigan, 미국, 49503
        • Cancer Research Consortium of West Michigan NCORP
      • Grand Rapids, Michigan, 미국, 49503
        • Trinity Health Grand Rapids Hospital
      • Grand Rapids, Michigan, 미국, 49503
        • Corewell Health Grand Rapids Hospitals - Butterworth Hospital
      • Jackson, Michigan, 미국, 49201
        • Allegiance Health
      • Kalamazoo, Michigan, 미국, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, 미국, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, 미국, 49048
        • Beacon Kalamazoo
      • Lansing, Michigan, 미국, 48912
        • University of Michigan Health - Sparrow Lansing
      • Livonia, Michigan, 미국, 48154
        • Trinity Health Saint Mary Mercy Livonia Hospital
      • Marquette, Michigan, 미국, 49855
        • UP Health System Marquette
      • Muskegon, Michigan, 미국, 49442
        • Mercy Health Partners-Hackley Campus
      • Muskegon, Michigan, 미국, 49444
        • Trinity Health Muskegon Hospital
      • Niles, Michigan, 미국, 49120
        • Corewell Health Lakeland Hospitals - Niles Hospital
      • Pontiac, Michigan, 미국, 48341
        • Trinity Health Saint Joseph Mercy Oakland Hospital
      • Port Huron, Michigan, 미국, 48060
        • Lake Huron Medical Center
      • Reed City, Michigan, 미국, 49677
        • Corewell Health Reed City Hospital
      • Royal Oak, Michigan, 미국, 48073
        • Corewell Health William Beaumont University Hospital
      • Saginaw, Michigan, 미국, 48601
        • MyMichigan Medical Center Saginaw
      • Saint Joseph, Michigan, 미국, 49085
        • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
      • Saint Joseph, Michigan, 미국, 49085
        • Corewell Health Lakeland Hospitals - Saint Joseph Hospital
      • Traverse City, Michigan, 미국, 49684
        • Munson Medical Center
      • Troy, Michigan, 미국, 48085
        • Corewell Health Beaumont Troy Hospital
      • Warren, Michigan, 미국, 48093
        • Henry Ford Health Warren Hospital
      • Wyoming, Michigan, 미국, 49519
        • University of Michigan Health - West
    • Minnesota
      • Alexandria, Minnesota, 미국, 56308
        • Medini, Eitan MD (UIA Investigator)
      • Brainerd, Minnesota, 미국, 56401
        • Essentia Health Saint Joseph's Medical Center
      • Burnsville, Minnesota, 미국, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, 미국, 55433
        • Mercy Hospital
      • Duluth, Minnesota, 미국, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, 미국, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, 미국, 55805
        • Miller-Dwan Hospital
      • Edina, Minnesota, 미국, 55435
        • Fairview Southdale Hospital
      • Fridley, Minnesota, 미국, 55432
        • Unity Hospital
      • Hutchinson, Minnesota, 미국, 55350
        • Hutchinson Area Health Care
      • Maplewood, Minnesota, 미국, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, 미국, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, 미국, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, 미국, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, 미국, 55454
        • Health Partners Inc
      • New Ulm, Minnesota, 미국, 56073
        • New Ulm Medical Center
      • Robbinsdale, Minnesota, 미국, 55422
        • North Memorial Medical Health Center
      • Saint Cloud, Minnesota, 미국, 56303
        • Coborn Cancer Center at Saint Cloud Hospital
      • Saint Cloud, Minnesota, 미국, 56303
        • Saint Cloud Hospital
      • Saint Louis Park, Minnesota, 미국, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Louis Park, Minnesota, 미국, 55416
        • Metro Minnesota Community Oncology Research Consortium
      • Saint Paul, Minnesota, 미국, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, 미국, 55102
        • United Hospital
      • Shakopee, Minnesota, 미국, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, 미국, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, 미국, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, 미국, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, 미국, 55125
        • Minnesota Oncology Hematology PA-Woodbury
    • Mississippi
      • Gulfport, Mississippi, 미국, 39502
        • Gulfport Memorial Hospital
      • Hattiesburg, Mississippi, 미국, 39401
        • Hattiesburg Clinic - Hematology/Oncology Clinic
      • Hattiesburg, Mississippi, 미국, 39404
        • Forrest General Hospital / Cancer Center
      • Jackson, Mississippi, 미국, 39216
        • University of Mississippi Medical Center
      • Pascagoula, Mississippi, 미국, 39581
        • Singing River Hospital
    • Missouri
      • Bolivar, Missouri, 미국, 65613
        • Central Care Cancer Center - Bolivar
      • Bonne Terre, Missouri, 미국, 63628
        • Parkland Health Center-Bonne Terre
      • Branson, Missouri, 미국, 65616
        • Cox Cancer Center Branson
      • Cape Girardeau, Missouri, 미국, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, 미국, 63701
        • Southeast Missouri Hospital
      • Cape Girardeau, Missouri, 미국, 63703
        • Mercy Cancer Center - Cape Girardeau
      • Columbia, Missouri, 미국, 65201
        • Veterans Administration
      • Columbia, Missouri, 미국, 65212
        • MU Health - University Hospital/Ellis Fischel Cancer Center
      • Independence, Missouri, 미국, 64057
        • Centerpoint Medical Center LLC
      • Jefferson City, Missouri, 미국, 65109
        • MU Health Care Goldschmidt Cancer Center
      • Joplin, Missouri, 미국, 64804
        • Freeman Health System
      • Joplin, Missouri, 미국, 64804
        • Mercy Hospital Joplin
      • Kansas City, Missouri, 미국, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, 미국, 64111
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, 미국, 64132
        • Research Medical Center
      • Kansas City, Missouri, 미국, 64118
        • Heartland Hematology and Oncology Associates Incorporated
      • Kansas City, Missouri, 미국, 64114
        • Saint Joseph Health Center
      • Kansas City, Missouri, 미국, 64108
        • University Health Truman Medical Center
      • Lee's Summit, Missouri, 미국, 64086
        • Saint Luke's East - Lee's Summit
      • Liberty, Missouri, 미국, 64068
        • Liberty Hospital
      • Rolla, Missouri, 미국, 65401
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Rolla, Missouri, 미국, 65401
        • Phelps Health Delbert Day Cancer Institute
      • Saint Joseph, Missouri, 미국, 64506
        • Heartland Regional Medical Center
      • Sainte Genevieve, Missouri, 미국, 63670
        • Sainte Genevieve County Memorial Hospital
      • Springfield, Missouri, 미국, 65804
        • Cancer Research for the Ozarks NCORP
      • Springfield, Missouri, 미국, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, 미국, 65804
        • Mercy Hospital Springfield
      • St Louis, Missouri, 미국, 63110
        • Washington University School of Medicine
      • St Louis, Missouri, 미국, 63131
        • Missouri Baptist Medical Center
      • St Louis, Missouri, 미국, 63104
        • SSM Health Saint Louis University Hospital
      • St Louis, Missouri, 미국, 63109
        • Mercy Infusion Center - Chippewa
      • St Louis, Missouri, 미국, 63141
        • Comprehensive Cancer Care PC
      • St Louis, Missouri, 미국, 63141
        • Mercy Hospital Saint Louis
      • St Louis, Missouri, 미국, 63141
        • Center for Cancer Care and Research
      • Sullivan, Missouri, 미국, 63080
        • Missouri Baptist Sullivan Hospital
    • Montana
      • Billings, Montana, 미국, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, 미국, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, 미국, 59102
        • Montana Cancer Consortium NCORP
      • Billings, Montana, 미국, 59101
        • Northern Rockies Radiation Oncology Center
      • Billings, Montana, 미국, 59102
        • Saint Vincent Frontier Cancer Center
      • Bozeman, Montana, 미국, 59715
        • Bozeman Health Deaconess Hospital
      • Butte, Montana, 미국, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, 미국, 59405
        • Great Falls Clinic
      • Great Falls, Montana, 미국, 59405
        • Berdeaux, Donald MD (UIA Investigator)
      • Great Falls, Montana, 미국, 59405
        • Benefis Sletten Cancer Institute
      • Havre, Montana, 미국, 59501
        • Northern Montana Hospital
      • Helena, Montana, 미국, 59601
        • Saint Peter's Community Hospital
      • Kalispell, Montana, 미국, 59901
        • Glacier Oncology PLLC
      • Kalispell, Montana, 미국, 59901
        • Kalispell Medical Oncology
      • Kalispell, Montana, 미국, 59901
        • Logan Health Medical Center
      • Missoula, Montana, 미국, 59802
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, 미국, 59804
        • Guardian Oncology and Center for Wellness
      • Missoula, Montana, 미국, 59802
        • Montana Cancer Specialists
      • Missoula, Montana, 미국, 59804
        • Community Medical Center
    • Nebraska
      • Grand Island, Nebraska, 미국, 68803
        • Nebraska Cancer Specialists/Oncology Hematology West PC
      • Kearney, Nebraska, 미국, 68847
        • CHI Health Good Samaritan
      • Kearney, Nebraska, 미국, 68845
        • Fred and Pamela Buffett Cancer Center - Kearney
      • Lincoln, Nebraska, 미국, 68506
        • Nebraska Hematology and Oncology
      • Lincoln, Nebraska, 미국, 68510
        • Nebraska Cancer Research Center
      • Lincoln, Nebraska, 미국, 68510
        • Saint Elizabeth Regional Medical Center
      • Lincoln, Nebraska, 미국, 68516
        • Cancer Partners of Nebraska
      • Norfolk, Nebraska, 미국, 68701
        • Faith Regional Health Services Carson Cancer Center
      • North Platte, Nebraska, 미국, 69101
        • Great Plains Health Callahan Cancer Center
      • Omaha, Nebraska, 미국, 68114
        • Nebraska Methodist Hospital
      • Omaha, Nebraska, 미국, 68198
        • University of Nebraska Medical Center
      • Omaha, Nebraska, 미국, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, 미국, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, 미국, 68130
        • Alegent Health Lakeside Hospital
      • Omaha, Nebraska, 미국, 68106
        • Missouri Valley Cancer Consortium
      • Omaha, Nebraska, 미국, 68124
        • Nebraska Cancer Specialists - Omaha
      • Omaha, Nebraska, 미국, 68130
        • Oncology Hematology West PC
      • Omaha, Nebraska, 미국, 68130
        • Urology Cancer Center PC
      • Omaha, Nebraska, 미국, 68122
        • Hematology and Oncology Consultants PC
      • Papillion, Nebraska, 미국, 68046
        • Midlands Community Hospital
      • Scottsbluff, Nebraska, 미국, 69361
        • Regional West Medical Center Cancer Center
    • Nevada
      • Henderson, Nevada, 미국, 89052
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, 미국, 89052
        • Cancer and Blood Specialists-Henderson
      • Henderson, Nevada, 미국, 89052
        • Las Vegas Cancer Center-Henderson
      • Henderson, Nevada, 미국, 89074
        • Comprehensive Cancer Centers of Nevada-Southeast Henderson
      • Henderson, Nevada, 미국, 89074
        • Oncology Las Vegas - Henderson
      • Las Vegas, Nevada, 미국, 89144
        • Summerlin Hospital Medical Center
      • Las Vegas, Nevada, 미국, 89106
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, 미국, 89119
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, 미국, 89128
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, 미국, 89144
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, 미국, 89148
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, 미국, 89169
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, 미국, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, 미국, 89106
        • Cancer and Blood Specialists-Shadow
      • Las Vegas, Nevada, 미국, 89109
        • HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
      • Las Vegas, Nevada, 미국, 89113
        • HealthCare Partners Medical Group Oncology/Hematology-San Martin
      • Las Vegas, Nevada, 미국, 89121
        • Cancer Therapy and Integrative Medicine
      • Las Vegas, Nevada, 미국, 89128
        • Cancer and Blood Specialists-Tenaya
      • Las Vegas, Nevada, 미국, 89128
        • HealthCare Partners Medical Group Oncology/Hematology-Tenaya
      • Las Vegas, Nevada, 미국, 89148-2405
        • Las Vegas Cancer Center-Medical Center
      • Las Vegas, Nevada, 미국, 89149
        • HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
      • Las Vegas, Nevada, 미국, 89120
        • Nevada Cancer Research Foundation NCORP
      • Las Vegas, Nevada, 미국, 89128
        • Oncology Las Vegas - Tenaya
      • Las Vegas, Nevada, 미국, 89183
        • OptumCare Cancer Care at Fort Apache
      • Reno, Nevada, 미국, 89502
        • Renown Regional Medical Center
    • New Jersey
      • Camden, New Jersey, 미국, 08103
        • Cooper Hospital University Medical Center
      • East Orange, New Jersey, 미국, 07018-1095
        • Veterans Adminstration New Jersey Health Care System
      • Hackensack, New Jersey, 미국, 07601
        • Hackensack University Medical Center
      • Morristown, New Jersey, 미국, 07960
        • Morristown Medical Center
      • Mullica Hill, New Jersey, 미국, 08062
        • Inspira Medical Center Mullica Hill
      • Newark, New Jersey, 미국, 07101
        • Rutgers New Jersey Medical School
      • Newark, New Jersey, 미국, 07112
        • Newark Beth Israel Medical Center
      • Summit, New Jersey, 미국, 07902
        • Overlook Hospital
      • Vineland, New Jersey, 미국, 08360
        • Inspira Medical Center Vineland
    • New Mexico
      • Albuquerque, New Mexico, 미국, 87102
        • Lovelace Medical Center-Saint Joseph Square
      • Albuquerque, New Mexico, 미국, 87106
        • University of New Mexico Cancer Center
      • Las Cruces, New Mexico, 미국, 88011
        • Memorial Medical Center-Las Cruces
    • New York
      • Auburn, New York, 미국, 13021
        • Hematology Oncology Associates of Central New York-Auburn
      • Brooklyn, New York, 미국, 11203
        • Kings County Hospital
      • Brooklyn, New York, 미국, 11209
        • Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
      • Brooklyn, New York, 미국, 11203
        • State University of New York Downstate Medical Center
      • Buffalo, New York, 미국, 14215
        • Veterans Affairs Western New York Health Care System-Buffalo
      • Camillus, New York, 미국, 13031
        • Hematology Oncology Associates of CNY at Camillus
      • Cooperstown, New York, 미국, 13326
        • Mary Imogene Bassett Hospital
      • East Syracuse, New York, 미국, 13057
        • Hematology Oncology Associates of Central New York-East Syracuse
      • Glens Falls, New York, 미국, 12801
        • Glens Falls Hospital
      • Middletown, New York, 미국, 10940
        • Garnet Health Medical Center
      • New York, New York, 미국, 10065
        • NYP/Weill Cornell Medical Center
      • New York, New York, 미국, 10003
        • Mount Sinai Union Square
      • The Bronx, New York, 미국, 10467
        • Montefiore Medical Center - Moses Campus
      • The Bronx, New York, 미국, 10461
        • Montefiore Medical Center-Weiler Hospital
      • Utica, New York, 미국, 13502
        • Faxton-Saint Luke's Healthcare
    • North Carolina
      • Charlotte, North Carolina, 미국, 28204
        • Novant Health Presbyterian Medical Center
      • Charlotte, North Carolina, 미국, 28207
        • Oncology Specialists of Charlotte
      • Charlotte, North Carolina, 미국, 28262
        • Southern Oncology Specialists-Charlotte
      • Charlotte, North Carolina, 미국, 28207
        • Novant Health Carolina Surgical - Randolph
      • Clinton, North Carolina, 미국, 28328
        • Southeastern Medical Oncology Center-Clinton
      • Goldsboro, North Carolina, 미국, 27534
        • Southeastern Medical Oncology Center-Goldsboro
      • Goldsboro, North Carolina, 미국, 27534
        • Wayne Memorial Hospital
      • Huntersville, North Carolina, 미국, 28078
        • Novant Health Cancer Institute - Huntersville
      • Huntersville, North Carolina, 미국, 28078
        • Southern Oncology Specialists-Huntersville
      • Jacksonville, North Carolina, 미국, 28546
        • Southeastern Medical Oncology Center-Jacksonville
      • Kinston, North Carolina, 미국, 28501
        • ECU Health Oncology Kinston
      • Matthews, North Carolina, 미국, 28105
        • Matthews Radiation Oncology Center
      • Matthews, North Carolina, 미국, 28105
        • Novant Health Cancer Institute - Matthews
      • Mooresville, North Carolina, 미국, 28117
        • Novant Health Cancer Institute - Mooresville
    • North Dakota
      • Bismarck, North Dakota, 미국, 58501
        • Sanford Bismarck Medical Center
      • Bismarck, North Dakota, 미국, 58501
        • Mid Dakota Clinic
      • Bismarck, North Dakota, 미국, 58501
        • Saint Alexius Medical Center
      • Grand Forks, North Dakota, 미국, 58201
        • Altru Cancer Center
      • Minot, North Dakota, 미국, 58701
        • Trinity Cancer Care Center
    • Ohio
      • Akron, Ohio, 미국, 44307
        • Cleveland Clinic Akron General
      • Akron, Ohio, 미국, 44304
        • Summa Health System - Akron Campus
      • Barberton, Ohio, 미국, 44203
        • Summa Health System - Barberton Campus
      • Beachwood, Ohio, 미국, 44122
        • UHHS-Chagrin Highlands Medical Center
      • Bellefontaine, Ohio, 미국, 43311
        • Mary Rutan Hospital
      • Belpre, Ohio, 미국, 45714
        • Strecker Cancer Center-Belpre
      • Canton, Ohio, 미국, 44708
        • Cleveland Clinic Mercy Hospital
      • Canton, Ohio, 미국, 44710
        • Aultman Health Foundation
      • Chillicothe, Ohio, 미국, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, 미국, 45219
        • University of Cincinnati Cancer Center-UC Medical Center
      • Cincinnati, Ohio, 미국, 45220
        • Good Samaritan Hospital - Cincinnati
      • Cincinnati, Ohio, 미국, 45242
        • Bethesda North Hospital
      • Cincinnati, Ohio, 미국, 45247
        • TriHealth Cancer Institute-Westside
      • Cincinnati, Ohio, 미국, 45255
        • TriHealth Cancer Institute-Anderson
      • Cleveland, Ohio, 미국, 44106
        • Case Western Reserve University
      • Cleveland, Ohio, 미국, 44109
        • MetroHealth Medical Center
      • Columbus, Ohio, 미국, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, 미국, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, 미국, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, 미국, 43214
        • Columbus Oncology and Hematology Associates Inc
      • Columbus, Ohio, 미국, 43228
        • Doctors Hospital
      • Columbus, Ohio, 미국, 43215
        • Grant Medical Center
      • Columbus, Ohio, 미국, 43222
        • Mount Carmel Health Center West
      • Columbus, Ohio, 미국, 43215
        • Columbus NCI Community Oncology Research Program
      • Dayton, Ohio, 미국, 45415
        • Miami Valley Hospital North
      • Dayton, Ohio, 미국, 45428
        • Dayton Veterans Affairs Medical Center
      • Delaware, Ohio, 미국, 43015
        • Delaware Health Center-Grady Cancer Center
      • Delaware, Ohio, 미국, 43015
        • Delaware Radiation Oncology
      • Delaware, Ohio, 미국, 43015
        • Grady Memorial Hospital
      • Greenville, Ohio, 미국, 45331
        • Wayne Hospital
      • Lancaster, Ohio, 미국, 43130
        • Fairfield Medical Center
      • Lancaster, Ohio, 미국, 43130
        • Lancaster Radiation Oncology
      • Lima, Ohio, 미국, 45801
        • Saint Rita's Medical Center
      • Marietta, Ohio, 미국, 45750
        • Marietta Memorial Hospital
      • Mayfield Heights, Ohio, 미국, 44124
        • UH Seidman Cancer Center at Landerbrook Health Center
      • Mentor, Ohio, 미국, 44060
        • UH Seidman Cancer Center at Lake Health Mentor Campus
      • Mount Vernon, Ohio, 미국, 43050
        • Knox Community Hospital
      • Newark, Ohio, 미국, 43055
        • Licking Memorial Hospital
      • Newark, Ohio, 미국, 43055
        • Newark Radiation Oncology
      • Portsmouth, Ohio, 미국, 45662
        • Southern Ohio Medical Center
      • Sandusky, Ohio, 미국, 44870
        • UH Seidman Cancer Center at Firelands Regional Medical Center
      • Springfield, Ohio, 미국, 45504
        • Springfield Regional Medical Center
      • Troy, Ohio, 미국, 45373
        • Upper Valley Medical Center
      • Westerville, Ohio, 미국, 43081
        • Saint Ann's Hospital
      • Westlake, Ohio, 미국, 44145
        • UHHS-Westlake Medical Center
      • Zanesville, Ohio, 미국, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Oklahoma City, Oklahoma, 미국, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, 미국, 73109
        • Integris Southwest Medical Center
      • Oklahoma City, Oklahoma, 미국, 73142
        • Integris Cancer Institute of Oklahoma
      • Oklahoma City, Oklahoma, 미국, 73120
        • Cancer Care Associates
      • Tulsa, Oklahoma, 미국, 74146
        • Oklahoma Cancer Specialists and Research Institute-Tulsa
    • Oregon
      • Salem, Oregon, 미국, 97301
        • Salem Hospital
    • Pennsylvania
      • Allentown, Pennsylvania, 미국, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Beaver, Pennsylvania, 미국, 15009
        • UPMC-Heritage Valley Health System Beaver
      • Bethlehem, Pennsylvania, 미국, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Bethlehem, Pennsylvania, 미국, 18015
        • Saint Luke's University Hospital-Bethlehem Campus
      • Danville, Pennsylvania, 미국, 17822
        • Geisinger Medical Center
      • Drexel Hill, Pennsylvania, 미국, 19026
        • Delaware County Memorial Hospital
      • East Stroudsburg, Pennsylvania, 미국, 18301
        • Pocono Medical Center
      • Greensburg, Pennsylvania, 미국, 15601
        • UPMC Cancer Centers - Arnold Palmer Pavilion
      • Hazleton, Pennsylvania, 미국, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Johnstown, Pennsylvania, 미국, 15901
        • UPMC-Johnstown/John P. Murtha Regional Cancer Center
      • Lewisburg, Pennsylvania, 미국, 17837
        • Geisinger Medical Oncology-Lewisburg
      • Lewistown, Pennsylvania, 미국, 17044
        • Lewistown Hospital
      • McKeesport, Pennsylvania, 미국, 15132
        • UPMC Cancer Center at UPMC McKeesport
      • Media, Pennsylvania, 미국, 19063
        • Riddle Memorial Hospital
      • Moon Township, Pennsylvania, 미국, 15108
        • UPMC Hillman Cancer Center in Coraopolis
      • Philadelphia, Pennsylvania, 미국, 19111
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, 미국, 19107
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, 미국, 19104
        • University of Pennsylvania/Abramson Cancer Center
      • Philadelphia, Pennsylvania, 미국, 19140
        • Temple University Hospital
      • Pittsburgh, Pennsylvania, 미국, 15212
        • Allegheny General Hospital
      • Pittsburgh, Pennsylvania, 미국, 15232
        • UPMC Hillman Cancer Center
      • Pittsburgh, Pennsylvania, 미국, 15213
        • UPMC-Magee Womens Hospital
      • Pittsburgh, Pennsylvania, 미국, 15232
        • UPMC-Shadyside Hospital
      • Pittsburgh, Pennsylvania, 미국, 15213
        • UPMC-Presbyterian Hospital
      • Pittsburgh, Pennsylvania, 미국, 15215
        • UPMC-Saint Margaret
      • Pittsburgh, Pennsylvania, 미국, 15236
        • UPMC Jefferson Regional Radiation Oncology
      • Pittsburgh, Pennsylvania, 미국, 15237
        • UPMC-Passavant Hospital
      • Pittsburgh, Pennsylvania, 미국, 15243
        • UPMC-Saint Clair Hospital Cancer Center
      • Pittsburgh, Pennsylvania, 미국, 15240
        • VA Pittsburgh Healthcare System
      • Pottsville, Pennsylvania, 미국, 17901
        • Geisinger Cancer Services-Pottsville
      • Reading, Pennsylvania, 미국, 19605
        • Penn State Health Saint Joseph Medical Center
      • Sayre, Pennsylvania, 미국, 18840
        • Guthrie Medical Group PC-Robert Packer Hospital
      • Scranton, Pennsylvania, 미국, 18510
        • Scranton Hematology Oncology
      • Scranton, Pennsylvania, 미국, 18501
        • Mercy Hospital
      • Scranton, Pennsylvania, 미국, 18508
        • Hematology and Oncology Associates of North East Pennsylvania
      • Seneca, Pennsylvania, 미국, 16346
        • UPMC Cancer Center at UPMC Northwest
      • State College, Pennsylvania, 미국, 16801
        • Geisinger Medical Group
      • Uniontown, Pennsylvania, 미국, 15401
        • UPMC Uniontown Hospital Radiation Oncology
      • Upland, Pennsylvania, 미국, 19013
        • Associates In Hematology Oncology PC-Upland
      • Washington, Pennsylvania, 미국, 15301
        • UPMC Washington Hospital Radiation Oncology
      • West Chester, Pennsylvania, 미국, 19380
        • Chester County Hospital
      • West Reading, Pennsylvania, 미국, 19611
        • Reading Hospital
      • Wilkes-Barre, Pennsylvania, 미국, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
      • Williamsport, Pennsylvania, 미국, 17701
        • UPMC Susquehanna
    • Rhode Island
      • Pawtucket, Rhode Island, 미국, 02860
        • Memorial Hospital of Rhode Island
      • Providence, Rhode Island, 미국, 02908
        • Roger Williams Medical Center
    • South Carolina
      • Boiling Springs, South Carolina, 미국, 29316
        • Prisma Health Cancer Institute - Spartanburg
      • Easley, South Carolina, 미국, 29640
        • Prisma Health Cancer Institute - Easley
      • Florence, South Carolina, 미국, 29506
        • McLeod Regional Medical Center
      • Greenville, South Carolina, 미국, 29605
        • Prisma Health Cancer Institute - Faris
      • Greenville, South Carolina, 미국, 29605
        • Prisma Health Cancer Institute - Butternut
      • Greenville, South Carolina, 미국, 29605
        • Prisma Health Greenville Memorial Hospital
      • Greenville, South Carolina, 미국, 29601
        • Greenville Health System Cancer Institute-Andrews
      • Greenwood, South Carolina, 미국, 29646
        • Self Regional Healthcare
      • Greer, South Carolina, 미국, 29650
        • Prisma Health Cancer Institute - Greer
      • Seneca, South Carolina, 미국, 29672
        • Prisma Health Cancer Institute - Seneca
    • South Dakota
      • Rapid City, South Dakota, 미국, 57701
        • Rapid City Regional Hospital
      • Sioux Falls, South Dakota, 미국, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, 미국, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, 미국, 57104
        • Sanford Cancer Center Oncology Clinic
      • Sioux Falls, South Dakota, 미국, 57105
        • Medical X-Ray Center
      • Sioux Falls, South Dakota, 미국, 57117-5045
        • Avera McKennan Hospital and University Health Center
    • Tennessee
      • Chattanooga, Tennessee, 미국, 37404
        • Memorial Hospital
      • Chattanooga, Tennessee, 미국, 37403
        • Erlanger Medical Center
      • Franklin, Tennessee, 미국, 37067
        • Vanderbilt-Ingram Cancer Center Cool Springs
      • Hixson, Tennessee, 미국, 37343
        • Pulmonary Medicine Center of Chattanooga-Hixson
      • Knoxville, Tennessee, 미국, 37920
        • University of Tennessee - Knoxville
      • Nashville, Tennessee, 미국, 37232
        • Vanderbilt University/Ingram Cancer Center
      • Nashville, Tennessee, 미국, 37208
        • Meharry Medical College
      • Nashville, Tennessee, 미국, 37203
        • Nashville Oncology Associates PC
      • Ooltewah, Tennessee, 미국, 37363
        • Memorial GYN Plus
    • Texas
      • Houston, Texas, 미국, 77030
        • Houston Methodist Hospital
      • Houston, Texas, 미국, 77030
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
      • Houston, Texas, 미국, 77030
        • Michael E DeBakey VA Medical Center
      • Houston, Texas, 미국, 77030
        • Ben Taub General Hospital
      • Houston, Texas, 미국, 77030
        • Baylor Saint Luke's Medical Center
      • Lubbock, Texas, 미국, 79430
        • Texas Tech University Health Sciences Center-Lubbock
      • San Antonio, Texas, 미국, 78229
        • University Hospital
      • San Antonio, Texas, 미국, 78229
        • University of Texas Health Science Center at San Antonio
      • San Antonio, Texas, 미국, 78229
        • Audie L Murphy VA Hospital
    • Utah
      • American Fork, Utah, 미국, 84003
        • American Fork Hospital / Huntsman Intermountain Cancer Center
      • Cedar City, Utah, 미국, 84720
        • Sandra L Maxwell Cancer Center
      • Logan, Utah, 미국, 84321
        • Logan Regional Hospital
      • Murray, Utah, 미국, 84107
        • Intermountain Medical Center
      • Ogden, Utah, 미국, 84403
        • McKay-Dee Hospital Center
      • Provo, Utah, 미국, 84604
        • Utah Valley Regional Medical Center
      • Salt Lake City, Utah, 미국, 84106
        • Utah Cancer Specialists-Salt Lake City
      • Salt Lake City, Utah, 미국, 84143
        • LDS Hospital
      • St. George, Utah, 미국, 84770
        • Saint George Regional Medical Center
    • Virginia
      • Danville, Virginia, 미국, 24541
        • Danville Regional Medical Center
      • Richmond, Virginia, 미국, 23298
        • VCU Massey Comprehensive Cancer Center
    • Washington
      • Bellingham, Washington, 미국, 98225
        • PeaceHealth Saint Joseph Medical Center
      • Burien, Washington, 미국, 98166
        • Saint Anne Hospital
      • Enumclaw, Washington, 미국, 98022
        • Saint Elizabeth Hospital
      • Federal Way, Washington, 미국, 98003
        • Saint Francis Hospital
      • Issaquah, Washington, 미국, 98029
        • Swedish Cancer Institute-Issaquah
      • Kirkland, Washington, 미국, 98033
        • EvergreenHealth Medical Center
      • Lakewood, Washington, 미국, 98499
        • Saint Clare Hospital
      • Port Angeles, Washington, 미국, 98362
        • Olympic Medical Center
      • Renton, Washington, 미국, 98055
        • Valley Medical Center
      • Renton, Washington, 미국, 98055
        • Southlake Clinic
      • Seattle, Washington, 미국, 98101
        • Virginia Mason Medical Center
      • Seattle, Washington, 미국, 98122
        • Swedish Medical Center-First Hill
      • Seattle, Washington, 미국, 98104
        • Pacific Medical Center-First Hill
      • Tacoma, Washington, 미국, 98405
        • Northwest Medical Specialties PLLC
      • Tacoma, Washington, 미국, 98405
        • Franciscan Research Center-Northwest Medical Plaza
    • West Virginia
      • Charleston, West Virginia, 미국, 25304
        • Vandalia Health/CAMC Institute for Academic Medicine
      • Huntington, West Virginia, 미국, 25701
        • Edwards Comprehensive Cancer Center
      • Morgantown, West Virginia, 미국, 26506
        • West Virginia University Healthcare
      • Parkersburg, West Virginia, 미국, 26101
        • Camden Clark Medical Center
    • Wisconsin
      • Antigo, Wisconsin, 미국, 54409
        • Aspirus Cancer Care-Antigo-Volm Cancer Center
      • Burlington, Wisconsin, 미국, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Chippewa Falls, Wisconsin, 미국, 54729
        • Marshfield Clinic-Chippewa Center
      • Eau Claire, Wisconsin, 미국, 54701
        • HSHS Sacred Heart Hospital
      • Eau Claire, Wisconsin, 미국, 54701
        • Marshfield Clinic Cancer Center at Sacred Heart
      • Fond du Lac, Wisconsin, 미국, 54937
        • Aurora Health Center-Fond du Lac
      • Green Bay, Wisconsin, 미국, 54311
        • Aurora BayCare Medical Center
      • Green Bay, Wisconsin, 미국, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, 미국, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Green Bay, Wisconsin, 미국, 54301-3526
        • Green Bay Oncology at Saint Vincent Hospital
      • Johnson Creek, Wisconsin, 미국, 53038
        • University of Wisconsin Carbone Cancer Center - Johnson Creek
      • Kenosha, Wisconsin, 미국, 53142
        • Aurora Cancer Care-Kenosha South
      • La Crosse, Wisconsin, 미국, 54601
        • Gundersen Lutheran Medical Center
      • Madison, Wisconsin, 미국, 53792
        • University of Wisconsin Carbone Cancer Center - University Hospital
      • Manitowoc, Wisconsin, 미국, 54221
        • Holy Family Memorial Hospital
      • Marinette, Wisconsin, 미국, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marinette, Wisconsin, 미국, 54143
        • Bay Area Medical Center
      • Marshfield, Wisconsin, 미국, 54449
        • Marshfield Medical Center-Marshfield
      • Marshfield, Wisconsin, 미국, 54449
        • Marshfield Medical Center
      • Mequon, Wisconsin, 미국, 53097
        • Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
      • Milwaukee, Wisconsin, 미국, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, 미국, 53211
        • Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
      • Minocqua, Wisconsin, 미국, 54548
        • Marshfield Medical Center - Minocqua
      • New Richmond, Wisconsin, 미국, 54017
        • Cancer Center of Western Wisconsin
      • Oconto Falls, Wisconsin, 미국, 54154
        • Saint Vincent Hospital Cancer Center at Oconto Falls
      • Oshkosh, Wisconsin, 미국, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, 미국, 53406
        • Aurora Cancer Care-Racine
      • Racine, Wisconsin, 미국, 53405
        • Ascension All Saints Hospital-Spring Street-Racine
      • Rhinelander, Wisconsin, 미국, 54501
        • Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
      • Rice Lake, Wisconsin, 미국, 54868
        • Marshfield Medical Center-Rice Lake
      • Sheboygan, Wisconsin, 미국, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Sheboygan, Wisconsin, 미국, 53081
        • HSHS Saint Nicholas Hospital
      • Stevens Point, Wisconsin, 미국, 54481
        • Aspirus Cancer Care - Stevens Point
      • Summit, Wisconsin, 미국, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, 미국, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Waukesha, Wisconsin, 미국, 53188
        • Aurora Cancer Care-Waukesha
      • Wausau, Wisconsin, 미국, 54401
        • Aspirus Cancer Care-Wausau
      • Weston, Wisconsin, 미국, 54476
        • Marshfield Medical Center - Weston
      • Wisconsin Rapids, Wisconsin, 미국, 54494
        • Aspirus Cancer Care - Wisconsin Rapids
      • Wisconsin Rapids, Wisconsin, 미국, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
    • Wyoming
      • Casper, Wyoming, 미국, 82609
        • Rocky Mountain Oncology
      • Cheyenne, Wyoming, 미국, 82001
        • Cheyenne Regional Medical Center-West
      • Sheridan, Wyoming, 미국, 82801
        • Welch Cancer Center
  • 푸에르토 리코
      • San Juan, 푸에르토 리코, 00936
        • San Juan City Hospital

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아니

연구 대상 성별

모두

설명

Inclusion Criteria:

  • Patients must have histologically or cytologically confirmed squamous cell cancer of the head and neck (SCCHN), from any primary site, including unknown primary cancers of the head and neck; patient must not have nasopharyngeal carcinoma of histologic types World Health Organization (WHO) 2 or 3 or squamous cell carcinoma that originated in the skin

  • Patients must have SCCHN that is either (a) recurrent, judged incurable by surgery or radiation or (b) metastatic; NOTE: Patients who refuse radical resection for recurrent disease are eligible; NOTE: A second primary squamous cell carcinoma of the head and neck is allowed if eligibility is based on a recurrent or metastatic first primary squamous cell carcinoma of the head and neck

  • No prior chemotherapy or biologic/molecular targeted therapy for recurrent or metastatic SCCHN

    • Patients may have received one regimen of induction, concomitant chemoradiotherapy and/or adjuvant chemotherapy as part of initial potential curative therapy but must not have received prior chemotherapy for recurrent or metastatic disease
    • A minimum of 4 months is required between last dose of chemotherapy or chemoradiotherapy and study treatment; in addition patients must be progression-free for at least 4 months after completion of chemotherapy or chemoradiotherapy or radiation plus cetuximab given with a curative intent; (cetuximab therapy: 4 months is required between last dose of chemotherapy or chemoradiotherapy and study treatment if part of concurrent regimen, 8 weeks if part of adjuvant regimen post radiation)
    • Patients having progression after 2 cycles of induction chemotherapy are not eligible for the study

  • No prior bevacizumab is allowed

  • A maximum of one prior radiotherapy regimen, curative or palliative, to the head and neck is allowed; if the radiation is combined with chemotherapy and/or cetuximab, a minimum of 4 months must elapse between the end of radiotherapy and registration; if the radiation is given alone, a minimum of 8 weeks must elapse between the end of radiotherapy and registration; a minimum of 3 weeks must elapse between prior radiation to other areas and registration

  • Patients must not be receiving any other investigational agent while on the study

  • Eastern Cooperative Oncology Group (ECOG) performance status of 0-1

  • Patients must have recovered to grade 1 or better from any acute effects of prior surgery, chemotherapy, or radiation therapy, and should be > 4 weeks post surgery; chronic late xerostomia, speech and swallowing abnormalities resulting from prior radiation or surgery are permitted if nutritional status is stable

  • Patients must have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST); baseline measurements and evaluations of all sites of disease must be obtained =< 4 weeks prior to randomization; disease in previously irradiated sites is considered measurable if there has been unequivocal disease progression or biopsy-proven residual carcinoma following radiation therapy; persistent disease after radiotherapy must be biopsy proven at least 8 weeks after completion of radiation therapy; (radiographic findings are acceptable providing that clear-cut measurements can be made)

  • Absolute neutrophil count (ANC) >= 1500/mm^3

  • Hemoglobin (Hgb) >= 8.0 g/dL

  • Platelet count >= 100,000/mm^3

  • Creatinine clearance of >= 60 ml/min; creatinine clearance may be measured or calculated; if calculating, creatinine clearance, use the Cockroft-Gault formula

  • Total bilirubin within normal limits (must be obtained =< 2 weeks prior to randomization)

  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) must be within the range allowing for eligibility

    • Alkaline phosphatase normal AND AST or ALT =< 5 x upper limit of normal (ULN)
    • Alkaline phosphatase > 1 but =< 2.5 x ULN AND AST or ALT > 1 but =< 1.5 x ULN
    • Alkaline phosphatase > 2.5 but =< 5 x ULN AND AST or ALT normal

  • Alkaline phosphatase must be within the range allowing for eligibility

  • Urine dipstick must be =< 0-1+ within 2 weeks (14 days) of randomization; if urine dipstick result is > 1+, a calculation of urine protein creatinine (UPC) ratio is required; patients must have a UPC ratio < 1.0 to participate in the study; NOTE: UPC ratio of spot urine is an estimation of the 24 urine protein excretion - a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gm

  • No known brain metastases

  • Patients who meet the following criteria will be excluded:

    • Tumors that invade major vessels (e.g. the carotid) as shown unequivocally by imaging studies
    • Central (i.e. within 2 cm from the hilum) lung metastases that are cavitary as shown unequivocally by imaging studies
    • Any prior history of bleeding related to the current head and neck cancer
    • History of gross hemoptysis (bright red blood of 1/2 teaspoon or more per episode of coughing) =< 3 months prior to enrollment

  • No history of coagulopathy or hemorrhagic disorders

  • Patients should not have a history of thrombosis (e.g. pulmonary embolism or deep venous thrombosis) currently requiring therapeutic anticoagulation (prophylactic use of warfarin 1 mg per day is allowed) and international normalized ratio (INR) should be < 1.5 at registration

  • Patients must not be receiving chronic daily treatment with aspirin (> 325 mg/day) or non-steroidal anti-inflammatory agents (NSAID's) known to inhibit platelet function; the use of anti-platelet agents (e.g. dipyridamole [Persantine], ticlopidine [Ticlid], clopidogrel [Plavix]) is allowed only if patient is not receiving aspirin or NSAID's known to inhibit platelet function

  • No hypercalcemia related to head and neck cancer

  • Patients with a prior history of squamous cell or basal carcinoma of the skin or in situ cervical cancer must have been curatively treated; patients with a history of other prior malignancy must have been treated with curative intent and must have remained disease-free for 3 years post diagnosis

  • No current peripheral neuropathy >= grade 2 at time of randomization

  • Patients must not have any co-existing condition that would preclude full compliance with the study

  • No prior history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80, if the physician's choice of chemotherapy regimen is docetaxel

  • All patients must have blood pressure =< 150/90 =< 2 weeks prior to randomization; patients with history of hypertension must be well-controlled upon study entry (=< 150/90) on a stable regimen of anti-hypertensive therapy

  • No major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study enrollment, or anticipation of need for major surgical procedure during the course of the study

  • No unstable angina or myocardial infarction within the previous 6 months; no symptomatic congestive heart failure, New York Heart Association (NYHA) grade II or greater; no history of aortic dissection or presence of aneurysm > 6 cm (or at high risk for rupture); no serious cardiac arrhythmia requiring medication (history of chronic atrial fibrillation or other atrial arrhythmia with controlled rate on medication is allowed); no clinically significant peripheral vascular disease manifested by intermittent claudication or need for vascular intervention; no history of aortic dissection; no history of any central nervous system (CNS) cerebrovascular ischemia or stroke within the last 6 months; no active serious infection

  • Patients should not have prior history of a serious human anti-human antibody (HAHA) reaction; patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies are not eligible

  • Women must not be pregnant or breast feeding; pregnant women are excluded from this study; women of child-bearing potential and men must agree to total abstinence or to use adequate hormonal or barrier method of birth control prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while in this study, she should inform her treating physician immediately; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy

  • Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study; appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicated

  • No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to registration

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 치료
  • 할당: 무작위
  • 중재 모델: 병렬 할당
  • 마스킹: 없음(오픈 라벨)

무기와 개입

참가자 그룹 / 팔
개입 / 치료
활성 비교기: Arm IA (docetaxel, cisplatin)

Patients receive docetaxel IV over 1 hour and cisplatin IV over 1-2 hours on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
다른: Laboratory Biomarker Analysis

Correlative studies

의약품: Cisplatin

Given IV

다른 이름들:
  • CDDP
  • 시스-디암민디클로리도백금
  • 시스마플라트
  • 시스플라티넘
  • 네오플라틴
  • 플라티놀
  • 아비플라틴
  • 블라스톨렘
  • 브리플라틴
  • 시스-디아민-디클로로백금
  • 시스-디아민디클로로 백금(II)
  • 시스-디아민디클로로백금
  • 시스-디클로로암민 백금(II)
  • 시스-백금 디아민 디클로라이드
  • 시스-백금
  • 시스-백금 II
  • 시스-백금 II 디아민 디클로라이드
  • 시스플라티나
  • 시스플라틸
  • 치토플라티노
  • 시토신
  • DDP
  • 레더플라틴
  • 메타플라틴
  • Peyrone의 염화물
  • 페이론의 소금
  • 플라시스
  • 플라스티스틸
  • 플라타민
  • 플라티블라스틴
  • 플라티블라스틴-S
  • 플래티넥스
  • 플라티놀-AQ
  • 플라티놀-AQ VHA 플러스
  • 플라티녹산
  • 백금
  • 백금 디암미노디클로라이드
  • 플라티란
  • 플라티스틴
  • 플라토신
의약품: Docetaxel

Given IV

다른 이름들:
  • 탁소테레
  • 도세캐드
  • RP56976
  • 탁소테레 주사 농축액
  • RP 56976
  • RP-56976
실험적: Arm IB (docetaxel, cisplatin, bevacizumab)

Patients receive bevacizumab IV over 30-90 minutes on day 1 and docetaxel and cisplatin as in Arm IA.
다른: Laboratory Biomarker Analysis

Correlative studies

생물학적: Bevacizumab

Given IV

다른 이름들:
  • 아바스틴
  • ABP 215
  • 안티-VEGF
  • 항-VEGF 인간화 단클론항체
  • 항-VEGF 단클론항체 SIBP04
  • 항-VEGF rhuMAb
  • 베바시주맙
  • 베바시주맙 바이오시밀러 ABP 215
  • 베바시주맙 바이오시밀러 BEVZ92
  • 베바시주맙 바이오시밀러 BI 695502
  • 베바시주맙 바이오시밀러 CBT 124
  • 베바시주맙 바이오시밀러 CT-P16
  • 베바시주맙 바이오시밀러 FKB238
  • 베바시주맙 바이오시밀러 GB-222
  • 베바시주맙 바이오시밀러 HD204
  • 베바시주맙 바이오시밀러 HLX04
  • 베바시주맙 바이오시밀러 IBI305
  • 베바시주맙 바이오시밀러 LY01008
  • 베바시주맙 바이오시밀러 MIL60
  • 베바시주맙 바이오시밀러 음바시
  • 베바시주맙 바이오시밀러 MYL-1402O
  • 베바시주맙 바이오시밀러 QL 1101
  • 베바시주맙 바이오시밀러 RPH-001
  • 베바시주맙 바이오시밀러 SCT501
  • 베바시주맙 바이오시밀러 지라베브
  • 베바시주맙-awwb
  • 베바시주맙-bvzr
  • BP102
  • BP102 바이오시밀러
  • HD204
  • 면역글로불린 G1(Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF 경쇄, 이합체
  • 음바시
  • MYL-1402O
  • 재조합 인간화 항-VEGF 단클론 항체
  • rhuMab-VEGF
  • SCT501
  • SIBP 04
  • SIBP-04
  • SIBP04
  • 지라베프
  • 아베그라
  • QL1101
  • IBI305
  • 비바스다
  • 베바시주맙 바이오시밀러 QL1101
  • 박쥐1706
  • 박쥐 1706
  • BAT-1706
  • BAT1706 바이오시밀러
  • 베바시주맙 바이오시밀러 BAT1706
  • 베바시주맙-adcd
  • CT-P16
  • 베그젤마
  • 알림시스
  • ABP-215
  • ABP215
  • 아이빈티오
  • 베바시주맙-아이비
  • 베바시주맙-에퀴
  • 베바시주맙-말리
  • 베바시주맙-온베
  • CT P16
  • CTP16
  • 등가
  • 온베브지
  • 아브지비
  • 베바시주맙 바이오시밀러 MB02
  • 베바시주맙-tnjn
  • FKB 238
  • FKB-238
  • FKB238
  • MB 02
  • MB-02
  • MB02
  • 오야바스
  • PF 06439535
  • PF-06439535
  • PF06439535
  • Bevacizumab-aveg
  • Bevacizumab-byva
  • Bevacizumab-nwgd
  • Jobevne
  • IBI 305
  • IBI-305
의약품: Cisplatin

Given IV

다른 이름들:
  • CDDP
  • 시스-디암민디클로리도백금
  • 시스마플라트
  • 시스플라티넘
  • 네오플라틴
  • 플라티놀
  • 아비플라틴
  • 블라스톨렘
  • 브리플라틴
  • 시스-디아민-디클로로백금
  • 시스-디아민디클로로 백금(II)
  • 시스-디아민디클로로백금
  • 시스-디클로로암민 백금(II)
  • 시스-백금 디아민 디클로라이드
  • 시스-백금
  • 시스-백금 II
  • 시스-백금 II 디아민 디클로라이드
  • 시스플라티나
  • 시스플라틸
  • 치토플라티노
  • 시토신
  • DDP
  • 레더플라틴
  • 메타플라틴
  • Peyrone의 염화물
  • 페이론의 소금
  • 플라시스
  • 플라스티스틸
  • 플라타민
  • 플라티블라스틴
  • 플라티블라스틴-S
  • 플래티넥스
  • 플라티놀-AQ
  • 플라티놀-AQ VHA 플러스
  • 플라티녹산
  • 백금
  • 백금 디암미노디클로라이드
  • 플라티란
  • 플라티스틴
  • 플라토신
의약품: Docetaxel

Given IV

다른 이름들:
  • 탁소테레
  • 도세캐드
  • RP56976
  • 탁소테레 주사 농축액
  • RP 56976
  • RP-56976
활성 비교기: Arm IIA (docetaxel, carboplatin)

Patients receive docetaxel IV over 1 hour and carboplatin IV over 30 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
의약품: Carboplatin

Given IV

다른 이름들:
  • 폭발탄
  • 카르보플라트
  • 카보플라틴 헥살
  • 카르보플라티노
  • 카보플라티넘
  • 카르보신
  • 카보솔
  • 카보텍
  • CBDCA
  • 디스플라타
  • 에르카르
  • JM-8
  • 닐로린
  • 노보플라티넘
  • 파라플라틴
  • 파라플라틴 AQ
  • 플라틴와스
  • 리보카르보
  • JM8
다른: Laboratory Biomarker Analysis

Correlative studies

의약품: Docetaxel

Given IV

다른 이름들:
  • 탁소테레
  • 도세캐드
  • RP56976
  • 탁소테레 주사 농축액
  • RP 56976
  • RP-56976
실험적: Arm IIB (docetaxel, carboplatin, bevacizumab)

Patients receive bevacizumab as in Arm IB and docetaxel and carboplatin as in Arm IIA.
의약품: Carboplatin

Given IV

다른 이름들:
  • 폭발탄
  • 카르보플라트
  • 카보플라틴 헥살
  • 카르보플라티노
  • 카보플라티넘
  • 카르보신
  • 카보솔
  • 카보텍
  • CBDCA
  • 디스플라타
  • 에르카르
  • JM-8
  • 닐로린
  • 노보플라티넘
  • 파라플라틴
  • 파라플라틴 AQ
  • 플라틴와스
  • 리보카르보
  • JM8
다른: Laboratory Biomarker Analysis

Correlative studies

생물학적: Bevacizumab

Given IV

다른 이름들:
  • 아바스틴
  • ABP 215
  • 안티-VEGF
  • 항-VEGF 인간화 단클론항체
  • 항-VEGF 단클론항체 SIBP04
  • 항-VEGF rhuMAb
  • 베바시주맙
  • 베바시주맙 바이오시밀러 ABP 215
  • 베바시주맙 바이오시밀러 BEVZ92
  • 베바시주맙 바이오시밀러 BI 695502
  • 베바시주맙 바이오시밀러 CBT 124
  • 베바시주맙 바이오시밀러 CT-P16
  • 베바시주맙 바이오시밀러 FKB238
  • 베바시주맙 바이오시밀러 GB-222
  • 베바시주맙 바이오시밀러 HD204
  • 베바시주맙 바이오시밀러 HLX04
  • 베바시주맙 바이오시밀러 IBI305
  • 베바시주맙 바이오시밀러 LY01008
  • 베바시주맙 바이오시밀러 MIL60
  • 베바시주맙 바이오시밀러 음바시
  • 베바시주맙 바이오시밀러 MYL-1402O
  • 베바시주맙 바이오시밀러 QL 1101
  • 베바시주맙 바이오시밀러 RPH-001
  • 베바시주맙 바이오시밀러 SCT501
  • 베바시주맙 바이오시밀러 지라베브
  • 베바시주맙-awwb
  • 베바시주맙-bvzr
  • BP102
  • BP102 바이오시밀러
  • HD204
  • 면역글로불린 G1(Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF 경쇄, 이합체
  • 음바시
  • MYL-1402O
  • 재조합 인간화 항-VEGF 단클론 항체
  • rhuMab-VEGF
  • SCT501
  • SIBP 04
  • SIBP-04
  • SIBP04
  • 지라베프
  • 아베그라
  • QL1101
  • IBI305
  • 비바스다
  • 베바시주맙 바이오시밀러 QL1101
  • 박쥐1706
  • 박쥐 1706
  • BAT-1706
  • BAT1706 바이오시밀러
  • 베바시주맙 바이오시밀러 BAT1706
  • 베바시주맙-adcd
  • CT-P16
  • 베그젤마
  • 알림시스
  • ABP-215
  • ABP215
  • 아이빈티오
  • 베바시주맙-아이비
  • 베바시주맙-에퀴
  • 베바시주맙-말리
  • 베바시주맙-온베
  • CT P16
  • CTP16
  • 등가
  • 온베브지
  • 아브지비
  • 베바시주맙 바이오시밀러 MB02
  • 베바시주맙-tnjn
  • FKB 238
  • FKB-238
  • FKB238
  • MB 02
  • MB-02
  • MB02
  • 오야바스
  • PF 06439535
  • PF-06439535
  • PF06439535
  • Bevacizumab-aveg
  • Bevacizumab-byva
  • Bevacizumab-nwgd
  • Jobevne
  • IBI 305
  • IBI-305
의약품: Docetaxel

Given IV

다른 이름들:
  • 탁소테레
  • 도세캐드
  • RP56976
  • 탁소테레 주사 농축액
  • RP 56976
  • RP-56976
활성 비교기: Arm IIIA (cisplatin, fluorouracil)

Patients receive cisplatin IV over 1-2 hours on day 1 and fluorouracil IV continuously on days 1-4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
다른: Laboratory Biomarker Analysis

Correlative studies

의약품: Cisplatin

Given IV

다른 이름들:
  • CDDP
  • 시스-디암민디클로리도백금
  • 시스마플라트
  • 시스플라티넘
  • 네오플라틴
  • 플라티놀
  • 아비플라틴
  • 블라스톨렘
  • 브리플라틴
  • 시스-디아민-디클로로백금
  • 시스-디아민디클로로 백금(II)
  • 시스-디아민디클로로백금
  • 시스-디클로로암민 백금(II)
  • 시스-백금 디아민 디클로라이드
  • 시스-백금
  • 시스-백금 II
  • 시스-백금 II 디아민 디클로라이드
  • 시스플라티나
  • 시스플라틸
  • 치토플라티노
  • 시토신
  • DDP
  • 레더플라틴
  • 메타플라틴
  • Peyrone의 염화물
  • 페이론의 소금
  • 플라시스
  • 플라스티스틸
  • 플라타민
  • 플라티블라스틴
  • 플라티블라스틴-S
  • 플래티넥스
  • 플라티놀-AQ
  • 플라티놀-AQ VHA 플러스
  • 플라티녹산
  • 백금
  • 백금 디암미노디클로라이드
  • 플라티란
  • 플라티스틴
  • 플라토신
의약품: Fluorouracil

Given IV

다른 이름들:
  • 5-플루라실
  • 플루라실
  • 5 플루오로우라실
  • 5 플루오로우라실룸
  • 5푸
  • 5-플루오로-2,4(1H,3H)-피리미딘디온
  • 5-플루오로우라실
  • 5-푸
  • 5FU
  • AccuSite
  • 카라크
  • 플루오로 우라실
  • 플루우라실
  • 플루라블라스틴
  • 플루라세딜
  • 플루릴
  • 플루로블라스틴
  • 리보플루오르
  • 로 2-9757호
  • Ro-2-9757
실험적: Arm IIIB (cisplatin, fluorouracil, bevacizumab)

Patients receive bevacizumab as in Arm IB and cisplatin and fluorouracil as in Arm IIIA.
다른: Laboratory Biomarker Analysis

Correlative studies

생물학적: Bevacizumab

Given IV

다른 이름들:
  • 아바스틴
  • ABP 215
  • 안티-VEGF
  • 항-VEGF 인간화 단클론항체
  • 항-VEGF 단클론항체 SIBP04
  • 항-VEGF rhuMAb
  • 베바시주맙
  • 베바시주맙 바이오시밀러 ABP 215
  • 베바시주맙 바이오시밀러 BEVZ92
  • 베바시주맙 바이오시밀러 BI 695502
  • 베바시주맙 바이오시밀러 CBT 124
  • 베바시주맙 바이오시밀러 CT-P16
  • 베바시주맙 바이오시밀러 FKB238
  • 베바시주맙 바이오시밀러 GB-222
  • 베바시주맙 바이오시밀러 HD204
  • 베바시주맙 바이오시밀러 HLX04
  • 베바시주맙 바이오시밀러 IBI305
  • 베바시주맙 바이오시밀러 LY01008
  • 베바시주맙 바이오시밀러 MIL60
  • 베바시주맙 바이오시밀러 음바시
  • 베바시주맙 바이오시밀러 MYL-1402O
  • 베바시주맙 바이오시밀러 QL 1101
  • 베바시주맙 바이오시밀러 RPH-001
  • 베바시주맙 바이오시밀러 SCT501
  • 베바시주맙 바이오시밀러 지라베브
  • 베바시주맙-awwb
  • 베바시주맙-bvzr
  • BP102
  • BP102 바이오시밀러
  • HD204
  • 면역글로불린 G1(Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF 경쇄, 이합체
  • 음바시
  • MYL-1402O
  • 재조합 인간화 항-VEGF 단클론 항체
  • rhuMab-VEGF
  • SCT501
  • SIBP 04
  • SIBP-04
  • SIBP04
  • 지라베프
  • 아베그라
  • QL1101
  • IBI305
  • 비바스다
  • 베바시주맙 바이오시밀러 QL1101
  • 박쥐1706
  • 박쥐 1706
  • BAT-1706
  • BAT1706 바이오시밀러
  • 베바시주맙 바이오시밀러 BAT1706
  • 베바시주맙-adcd
  • CT-P16
  • 베그젤마
  • 알림시스
  • ABP-215
  • ABP215
  • 아이빈티오
  • 베바시주맙-아이비
  • 베바시주맙-에퀴
  • 베바시주맙-말리
  • 베바시주맙-온베
  • CT P16
  • CTP16
  • 등가
  • 온베브지
  • 아브지비
  • 베바시주맙 바이오시밀러 MB02
  • 베바시주맙-tnjn
  • FKB 238
  • FKB-238
  • FKB238
  • MB 02
  • MB-02
  • MB02
  • 오야바스
  • PF 06439535
  • PF-06439535
  • PF06439535
  • Bevacizumab-aveg
  • Bevacizumab-byva
  • Bevacizumab-nwgd
  • Jobevne
  • IBI 305
  • IBI-305
의약품: Cisplatin

Given IV

다른 이름들:
  • CDDP
  • 시스-디암민디클로리도백금
  • 시스마플라트
  • 시스플라티넘
  • 네오플라틴
  • 플라티놀
  • 아비플라틴
  • 블라스톨렘
  • 브리플라틴
  • 시스-디아민-디클로로백금
  • 시스-디아민디클로로 백금(II)
  • 시스-디아민디클로로백금
  • 시스-디클로로암민 백금(II)
  • 시스-백금 디아민 디클로라이드
  • 시스-백금
  • 시스-백금 II
  • 시스-백금 II 디아민 디클로라이드
  • 시스플라티나
  • 시스플라틸
  • 치토플라티노
  • 시토신
  • DDP
  • 레더플라틴
  • 메타플라틴
  • Peyrone의 염화물
  • 페이론의 소금
  • 플라시스
  • 플라스티스틸
  • 플라타민
  • 플라티블라스틴
  • 플라티블라스틴-S
  • 플래티넥스
  • 플라티놀-AQ
  • 플라티놀-AQ VHA 플러스
  • 플라티녹산
  • 백금
  • 백금 디암미노디클로라이드
  • 플라티란
  • 플라티스틴
  • 플라토신
의약품: Fluorouracil

Given IV

다른 이름들:
  • 5-플루라실
  • 플루라실
  • 5 플루오로우라실
  • 5 플루오로우라실룸
  • 5푸
  • 5-플루오로-2,4(1H,3H)-피리미딘디온
  • 5-플루오로우라실
  • 5-푸
  • 5FU
  • AccuSite
  • 카라크
  • 플루오로 우라실
  • 플루우라실
  • 플루라블라스틴
  • 플루라세딜
  • 플루릴
  • 플루로블라스틴
  • 리보플루오르
  • 로 2-9757호
  • Ro-2-9757
활성 비교기: Arm IVA (carboplatin, fluorouracil)

Patients receive carboplatin IV over 30 minutes on day 1 and fluorouracil IV continuously on days 1-4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
의약품: Carboplatin

Given IV

다른 이름들:
  • 폭발탄
  • 카르보플라트
  • 카보플라틴 헥살
  • 카르보플라티노
  • 카보플라티넘
  • 카르보신
  • 카보솔
  • 카보텍
  • CBDCA
  • 디스플라타
  • 에르카르
  • JM-8
  • 닐로린
  • 노보플라티넘
  • 파라플라틴
  • 파라플라틴 AQ
  • 플라틴와스
  • 리보카르보
  • JM8
다른: Laboratory Biomarker Analysis

Correlative studies

의약품: Fluorouracil

Given IV

다른 이름들:
  • 5-플루라실
  • 플루라실
  • 5 플루오로우라실
  • 5 플루오로우라실룸
  • 5푸
  • 5-플루오로-2,4(1H,3H)-피리미딘디온
  • 5-플루오로우라실
  • 5-푸
  • 5FU
  • AccuSite
  • 카라크
  • 플루오로 우라실
  • 플루우라실
  • 플루라블라스틴
  • 플루라세딜
  • 플루릴
  • 플루로블라스틴
  • 리보플루오르
  • 로 2-9757호
  • Ro-2-9757
실험적: Arm IVB (carboplatin, fluorouracil, bevacizumab)

Patients receive bevacizumab as in Arm IB and carboplatin and fluorouracil as in Arm IVA.
의약품: Carboplatin

Given IV

다른 이름들:
  • 폭발탄
  • 카르보플라트
  • 카보플라틴 헥살
  • 카르보플라티노
  • 카보플라티넘
  • 카르보신
  • 카보솔
  • 카보텍
  • CBDCA
  • 디스플라타
  • 에르카르
  • JM-8
  • 닐로린
  • 노보플라티넘
  • 파라플라틴
  • 파라플라틴 AQ
  • 플라틴와스
  • 리보카르보
  • JM8
다른: Laboratory Biomarker Analysis

Correlative studies

생물학적: Bevacizumab

Given IV

다른 이름들:
  • 아바스틴
  • ABP 215
  • 안티-VEGF
  • 항-VEGF 인간화 단클론항체
  • 항-VEGF 단클론항체 SIBP04
  • 항-VEGF rhuMAb
  • 베바시주맙
  • 베바시주맙 바이오시밀러 ABP 215
  • 베바시주맙 바이오시밀러 BEVZ92
  • 베바시주맙 바이오시밀러 BI 695502
  • 베바시주맙 바이오시밀러 CBT 124
  • 베바시주맙 바이오시밀러 CT-P16
  • 베바시주맙 바이오시밀러 FKB238
  • 베바시주맙 바이오시밀러 GB-222
  • 베바시주맙 바이오시밀러 HD204
  • 베바시주맙 바이오시밀러 HLX04
  • 베바시주맙 바이오시밀러 IBI305
  • 베바시주맙 바이오시밀러 LY01008
  • 베바시주맙 바이오시밀러 MIL60
  • 베바시주맙 바이오시밀러 음바시
  • 베바시주맙 바이오시밀러 MYL-1402O
  • 베바시주맙 바이오시밀러 QL 1101
  • 베바시주맙 바이오시밀러 RPH-001
  • 베바시주맙 바이오시밀러 SCT501
  • 베바시주맙 바이오시밀러 지라베브
  • 베바시주맙-awwb
  • 베바시주맙-bvzr
  • BP102
  • BP102 바이오시밀러
  • HD204
  • 면역글로불린 G1(Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF 경쇄, 이합체
  • 음바시
  • MYL-1402O
  • 재조합 인간화 항-VEGF 단클론 항체
  • rhuMab-VEGF
  • SCT501
  • SIBP 04
  • SIBP-04
  • SIBP04
  • 지라베프
  • 아베그라
  • QL1101
  • IBI305
  • 비바스다
  • 베바시주맙 바이오시밀러 QL1101
  • 박쥐1706
  • 박쥐 1706
  • BAT-1706
  • BAT1706 바이오시밀러
  • 베바시주맙 바이오시밀러 BAT1706
  • 베바시주맙-adcd
  • CT-P16
  • 베그젤마
  • 알림시스
  • ABP-215
  • ABP215
  • 아이빈티오
  • 베바시주맙-아이비
  • 베바시주맙-에퀴
  • 베바시주맙-말리
  • 베바시주맙-온베
  • CT P16
  • CTP16
  • 등가
  • 온베브지
  • 아브지비
  • 베바시주맙 바이오시밀러 MB02
  • 베바시주맙-tnjn
  • FKB 238
  • FKB-238
  • FKB238
  • MB 02
  • MB-02
  • MB02
  • 오야바스
  • PF 06439535
  • PF-06439535
  • PF06439535
  • Bevacizumab-aveg
  • Bevacizumab-byva
  • Bevacizumab-nwgd
  • Jobevne
  • IBI 305
  • IBI-305
의약품: Fluorouracil

Given IV

다른 이름들:
  • 5-플루라실
  • 플루라실
  • 5 플루오로우라실
  • 5 플루오로우라실룸
  • 5푸
  • 5-플루오로-2,4(1H,3H)-피리미딘디온
  • 5-플루오로우라실
  • 5-푸
  • 5FU
  • AccuSite
  • 카라크
  • 플루오로 우라실
  • 플루우라실
  • 플루라블라스틴
  • 플루라세딜
  • 플루릴
  • 플루로블라스틴
  • 리보플루오르
  • 로 2-9757호
  • Ro-2-9757

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
Overall Survival (OS)
기간: assessed every 3 months within 2 years from study entry, then every 6 months up to 5 years from study entry

Overall survival (OS) was defined as time from randomization to death from any course. Patients who were alive were censored at the last contact date. Median OS was estimated using the Kaplan-Meier method.
assessed every 3 months within 2 years from study entry, then every 6 months up to 5 years from study entry

2차 결과 측정

결과 측정
측정값 설명
기간
Progression-free Survival (PFS)
기간: on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks

Progression was defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions. Progression-free survival (PFS) was defined as the time from randomization to date of disease progression or death from any cause, whichever occurred first. Patients who were still alive and progression free were censored at last disease assessment date. Median PFS was estimated using Kaplan-Meier method.
on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks
Overall Response Rate
기간: on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks

Overall response rate is defined as number of patients with complete response (CR) or partial response (PR) divided by all patients. Responses are evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST) guideline. CR is defined as disappearance of all target and non-target lesions. PR is defined as disappearance of target lesions or at least a 30% decrease in the sum of the diameters of target lesions (taking as reference the baseline sum diameters), and persistence of one or more non-target lesion(s).
on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks

기타 결과 측정

결과 측정
측정값 설명
기간
To Collect Blood Samples Before and After Therapy for Future Correlative Studies
기간: Before and after therapy

These were blood and tissue samples collections and have no data to report.
Before and after therapy
To Collect Tumor Tissue Samples Available at Baseline From Prior Diagnostic Procedures for Future Correlative Studies
기간: Baseline

These were blood and tissue samples collections and have no data to report.
Baseline

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

스폰서

National Cancer Institute (NCI)

수사관

  • 수석 연구원: Athanassios (Ethan) Argiris, ECOG-ACRIN Cancer Research Group

간행물 및 유용한 링크

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일반 간행물

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (실제)

2008년 8월 8일

기본 완료 (실제)

2018년 6월 5일

연구 완료 (추정된)

2027년 2월 20일

연구 등록 날짜

최초 제출

2007년 12월 28일

QC 기준을 충족하는 최초 제출

2007년 12월 28일

처음 게시됨 (추정된)

2008년 1월 9일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2026년 10월 22일

QC 기준을 충족하는 마지막 업데이트 제출

2026년 10월 21일

마지막으로 확인됨

2026년 8월 1일

추가 정보

이 연구와 관련된 용어

추가 관련 MeSH 약관

기타 연구 ID 번호

  • NCI-2009-00507
  • U10CA180820 (미국 NIH 보조금/계약)
  • U10CA021115 (미국 NIH 보조금/계약)
  • NCI-2009-00507 (레지스트리 식별자: CTRP (Clinical Trial Reporting Program))
  • E1305 (기타 식별자: CTEP)
  • CDR0000582533
  • E1305
  • E1305 (기타 식별자: ECOG-ACRIN Cancer Research Group)

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