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Chemoterapie s bevacizumabem nebo bez něj při léčbě pacientů s recidivujícím nebo metastatickým spinocelulárním karcinomem hlavy a krku

21. října 2026 aktualizováno: National Cancer Institute (NCI)

Randomizovaná studie fáze III chemoterapie s bevacizumabem nebo bez něj u pacientů s recidivujícím nebo metastatickým karcinomem hlavy a krku

This randomized phase III trial studies chemotherapy to see how well it works with or without bevacizumab in treating patients with head and neck squamous cell carcinoma that has come back (recurrent) or that has spread to other parts of the body (metastatic). Drugs used in chemotherapy, such as docetaxel, cisplatin, carboplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Bevacizumab may also make tumor cells more sensitive to chemotherapy and stop the growth of head and neck cancer by blocking blood flow to the tumor. It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab in treating patients with head and neck squamous cell carcinoma.

Přehled studie

Postavení

Aktivní, ne nábor

Podmínky

Intervence / Léčba

Detailní popis

PRIMARY OBJECTIVES:

I. To compare the overall survival of patients with recurrent or metastatic head and neck cancer treated with standard platinum-based chemotherapy with or without bevacizumab.

SECONDARY OBJECTIVES:

I. To assess toxicities with the addition of bevacizumab to each platinum-doublet (cisplatin/docetaxel, carboplatin/docetaxel, cisplatin/fluorouracil [5-FU], carboplatin/5-FU).

II. To compare the objective response rates and the progression-free survival achieved with the above therapies.

III. To collect blood samples before and after therapy for future correlative studies.

IV. To collect tumor tissue samples available at baseline from prior diagnostic procedures for future correlative studies.

OUTLINE: After the physician decides which chemotherapy doublet to use, patients are randomized to 1 of 2 treatment arms for that chemotherapy combination.

ARM IA: Patients receive chemotherapy comprising docetaxel intravenously (IV) over 1 hour and cisplatin IV over 1-2 hours on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IB: Patients receive bevacizumab IV over 30-90 minutes on day 1 and docetaxel and cisplatin as in Arm IA.

ARM IIA: Patients receive docetaxel IV over 1 hour and carboplatin IV over 30 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IIB: Patients receive bevacizumab as in arm IB and docetaxel and carboplatin as in Arm IIA.

ARM IIIA: Patients receive cisplatin IV over 1-2 hours on day 1 and fluorouracil IV continuously on days 1-4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IIIB: Patients receive bevacizumab as in Arm IB and cisplatin and fluorouracil as in Arm IIIA.

ARM IVA: Patients receive carboplatin IV over 30 minutes on day 1 and fluorouracil IV continuously on days 1-4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IVB: Patients receive bevacizumab as in Arm IB and carboplatin and fluorouracil as in Arm IVA.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Typ studie

Intervenční

Zápis (Aktuální)

403

Fáze

Fáze 3

Kontakty a umístění

Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.

Studijní místa

Jižní Afrika
- - Pretoria, Jižní Afrika, 0002
    - University Of Pretoria
Portoriko
- - San Juan, Portoriko, 00936
    - San Juan City Hospital
Spojené státy
- Alabama
  - Mobile, Alabama, Spojené státy, 36688
    - University of South Alabama Mitchell Cancer Institute
  - Mobile, Alabama, Spojené státy, 36608
    - Providence Hospital
- Alaska
  - Fairbanks, Alaska, Spojené státy, 99701
    - Fairbanks Memorial Hospital
- Arkansas
  - Fort Smith, Arkansas, Spojené státy, 72903
    - Mercy Hospital Fort Smith
  - Jonesboro, Arkansas, Spojené státy, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
  - Little Rock, Arkansas, Spojené státy, 72205
    - University of Arkansas for Medical Sciences
  - Little Rock, Arkansas, Spojené státy, 72205
    - John L McClellan Memorial Veterans Hospital
- California
  - Anaheim, California, Spojené státy, 92806
    - Kaiser Permanente-Anaheim
  - Baldwin Park, California, Spojené státy, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Spojené státy, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Spojené státy, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burlingame, California, Spojené státy, 94010
    - Mills-Peninsula Medical Center
  - Castro Valley, California, Spojené státy, 94546
    - Eden Hospital Medical Center
  - Castro Valley, California, Spojené státy, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Spojené státy, 94546
    - Valley Medical Oncology Consultants-Castro Valley
  - Dublin, California, Spojené státy, 94568
    - Epic Care-Dublin
  - Emeryville, California, Spojené státy, 94608
    - Bay Area Breast Surgeons Inc
  - Emeryville, California, Spojené státy, 94608
    - Epic Care Partners in Cancer Care
  - Fontana, California, Spojené státy, 92335
    - Kaiser Permanente-Fontana
  - Fremont, California, Spojené státy, 94538
    - Valley Medical Oncology Consultants-Fremont
  - Harbor City, California, Spojené státy, 90710
    - Kaiser Permanente South Bay
  - Irvine, California, Spojené státy, 92618
    - Kaiser Permanente-Irvine
  - La Jolla, California, Spojené státy, 92093
    - UC San Diego Moores Cancer Center
  - Los Angeles, California, Spojené státy, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Spojené státy, 90034
    - Kaiser Permanente West Los Angeles
  - Martinez, California, Spojené státy, 94553-3156
    - Contra Costa Regional Medical Center
  - Modesto, California, Spojené státy, 95355
    - Memorial Medical Center
  - Mountain View, California, Spojené státy, 94040
    - El Camino Hospital
  - Novato, California, Spojené státy, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Spojené státy, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Spojené státy, 94609
    - Hematology and Oncology Associates-Oakland
  - Oakland, California, Spojené státy, 94609
    - Tom K Lee Inc
  - Oakland, California, Spojené státy, 94609
    - Bay Area Tumor Institute
  - Oakland, California, Spojené státy, 94602
    - Wilma Chan Highland Hospital
  - Palo Alto, California, Spojené státy, 94304
    - VA Palo Alto Health Care System
  - Palo Alto, California, Spojené státy, 94304
    - Stanford Cancer Institute Palo Alto
  - Panorama City, California, Spojené státy, 91402
    - Kaiser Permanente - Panorama City
  - Pleasanton, California, Spojené státy, 94588
    - Valley Care Health System - Pleasanton
  - Pleasanton, California, Spojené státy, 94588
    - Valley Medical Oncology Consultants
  - Riverside, California, Spojené státy, 92505
    - Kaiser Permanente-Riverside
  - San Diego, California, Spojené státy, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Spojené státy, 92161
    - San Diego VA Medical Center
  - San Diego, California, Spojené státy, 92108
    - Kaiser Permanente-Rio San Diego
  - San Francisco, California, Spojené státy, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Marcos, California, Spojené státy, 92078
    - Kaiser Permanente-San Marcos
  - San Pablo, California, Spojené státy, 94806
    - Doctors Medical Center- JC Robinson Regional Cancer Center
  - Santa Rosa, California, Spojené státy, 95403
    - Sutter Pacific Medical Foundation
  - St. Helena, California, Spojené státy, 94574
    - Saint Helena Hospital
  - Vallejo, California, Spojené státy, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Woodland Hills, California, Spojené státy, 91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Aurora, Colorado, Spojené státy, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Spojené státy, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Spojené státy, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Spojené státy, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Spojené státy, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Spojené státy, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Denver, Colorado, Spojené státy, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Spojené státy, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Spojené státy, 80220
    - Rose Medical Center
  - Denver, Colorado, Spojené státy, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Spojené státy, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Spojené státy, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Spojené státy, 80222
    - Western States Cancer Research NCORP
  - Denver, Colorado, Spojené státy, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Denver, Colorado, Spojené státy, 80210
    - AdventHealth Porter
  - Durango, Colorado, Spojené státy, 81301
    - Mercy Medical Center
  - Durango, Colorado, Spojené státy, 81301
    - CommonSpirit Cancer Center Mercy
  - Englewood, Colorado, Spojené státy, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Spojené státy, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Spojené státy, 80524
    - Poudre Valley Hospital
  - Golden, Colorado, Spojené státy, 80401
    - Mountain Blue Cancer Care Center
  - Grand Junction, Colorado, Spojené státy, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Spojené státy, 80631
    - Banner North Colorado Medical Center
  - Greenwood Village, Colorado, Spojené státy, 80111
    - Rocky Mountain Cancer Centers-Greenwood Village
  - Lafayette, Colorado, Spojené státy, 80026
    - Kaiser Permanente-Rock Creek
  - Lakewood, Colorado, Spojené státy, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Lakewood, Colorado, Spojené státy, 80228
    - CommonSpirit Saint Anthony Hospital Cancer Center
  - Littleton, Colorado, Spojené státy, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Spojené státy, 80122
    - AdventHealth Littleton
  - Lone Tree, Colorado, Spojené státy, 80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree, Colorado, Spojené státy, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Spojené státy, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Spojené státy, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Spojené státy, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Spojené státy, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Parker, Colorado, Spojené státy, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Parker, Colorado, Spojené státy, 80138
    - AdventHealth Parker
  - Pueblo, Colorado, Spojené státy, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Spojené státy, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Spojené státy, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Spojené státy, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Spojené státy, 80401
    - Intermountain Health Lutheran Hospital
- Connecticut
  - Farmington, Connecticut, Spojené státy, 06030
    - University of Connecticut
  - Hartford, Connecticut, Spojené státy, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - New Britain, Connecticut, Spojené státy, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Spojené státy, 06520
    - Yale University
  - Norwich, Connecticut, Spojené státy, 06360
    - Eastern Connecticut Hematology and Oncology Associates
- Delaware
  - Dover, Delaware, Spojené státy, 19901
    - Bayhealth Hospital Kent Campus
  - Lewes, Delaware, Spojené státy, 19958
    - Beebe Medical Center
  - Newark, Delaware, Spojené státy, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Spojené státy, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Spojené státy, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Spojené státy, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Spojené státy, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Spojené státy, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Spojené státy, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Spojené státy, 20037
    - George Washington University Medical Center
  - Washington D.C., District of Columbia, Spojené státy, 20007
    - MedStar Georgetown University Hospital
- Florida
  - Boca Raton, Florida, Spojené státy, 33486
    - Boca Raton Regional Hospital
  - Fort Lauderdale, Florida, Spojené státy, 33316
    - Broward Health Medical Center
  - Fort Lauderdale, Florida, Spojené státy, 33308
    - Holy Cross Hospital
  - Gainesville, Florida, Spojené státy, 32605
    - Florida Cancer Specialists-Gainesville Cancer Center
  - Gainesville, Florida, Spojené státy, 32610
    - UF Health Cancer Institute - Gainesville
  - Hollywood, Florida, Spojené státy, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Spojené státy, 32207
    - Baptist MD Anderson Cancer Center
  - Jupiter, Florida, Spojené státy, 33458
    - Jupiter Medical Center
  - Miami, Florida, Spojené státy, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami Beach, Florida, Spojené státy, 33140
    - Mount Sinai Medical Center
  - Pembroke Pines, Florida, Spojené státy, 33028
    - Memorial Hospital West
  - Pensacola, Florida, Spojené státy, 32504
    - Sacred Heart Hospital
  - Titusville, Florida, Spojené státy, 32796
    - Space Coast Cancer Centers-Titusville
  - Weston, Florida, Spojené státy, 33331
    - Cleveland Clinic-Weston
- Georgia
  - Atlanta, Georgia, Spojené státy, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Spojené státy, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Spojené státy, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Spojené státy, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Spojené státy, 30342
    - Northside Hospital
  - Atlanta, Georgia, Spojené státy, 30342
    - Atlanta Regional CCOP
  - Austell, Georgia, Spojené státy, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, Spojené státy, 31904
    - John B Amos Cancer Center
  - Decatur, Georgia, Spojené státy, 30033
    - Atlanta VA Medical Center
  - Decatur, Georgia, Spojené státy, 30033
    - Emory Decatur Hospital
  - Fayetteville, Georgia, Spojené státy, 30214
    - Piedmont Fayette Hospital
  - Gainesville, Georgia, Spojené státy, 30501
    - Northeast Georgia Medical Center-Gainesville
  - Lawrenceville, Georgia, Spojené státy, 30046
    - Northside Hospital - Gwinnett
  - Marietta, Georgia, Spojené státy, 30060
    - Wellstar Kennestone Hospital
  - Riverdale, Georgia, Spojené státy, 30274
    - Southern Regional Medical Center
  - Rome, Georgia, Spojené státy, 30165
    - Harbin Clinic Medical Oncology and Clinical Research
  - Savannah, Georgia, Spojené státy, 31404
    - Memorial Health University Medical Center
  - Savannah, Georgia, Spojené státy, 31404
    - Summit Cancer Care-Memorial
  - Savannah, Georgia, Spojené státy, 31404
    - Low Country Cancer Care
- Hawaii
  - Honolulu, Hawaii, Spojené státy, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Spojené státy, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Spojené státy, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Spojené státy, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Spojené státy, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Spojené státy, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, Spojené státy, 96826
    - Kapiolani Medical Center for Women and Children
  - Wailuku, Hawaii, Spojené státy, 96793
    - Maui Memorial Medical Center
  - Wailuku, Hawaii, Spojené státy, 96793
    - Pacific Cancer Institute of Maui
  - ‘Aiea, Hawaii, Spojené státy, 96701
    - Pali Momi Medical Center
- Idaho
  - Boise, Idaho, Spojené státy, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Spojené státy, 83712
    - Saint Luke's Cancer Institute - Boise
  - Fruitland, Idaho, Spojené státy, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Spojené státy, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Spojené státy, 83687
    - Saint Luke's Cancer Institute - Nampa
  - Post Falls, Idaho, Spojené státy, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Twin Falls, Idaho, Spojené státy, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Aurora, Illinois, Spojené státy, 60504
    - Rush-Copley Medical Center
  - Berwyn, Illinois, Spojené státy, 60402
    - Mac Neal Hospital
  - Bloomington, Illinois, Spojené státy, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Spojené státy, 61701
    - OSF Saint Joseph Medical Center
  - Canton, Illinois, Spojené státy, 61520
    - Illinois CancerCare-Canton
  - Canton, Illinois, Spojené státy, 61520
    - Graham Hospital Association
  - Carbondale, Illinois, Spojené státy, 62902
    - Memorial Hospital of Carbondale
  - Carthage, Illinois, Spojené státy, 62321
    - Illinois CancerCare-Carthage
  - Carthage, Illinois, Spojené státy, 62321
    - Memorial Hospital
  - Centralia, Illinois, Spojené státy, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Spojené státy, 60611
    - Northwestern University
  - Chicago, Illinois, Spojené státy, 60612
    - University of Illinois
  - Chicago, Illinois, Spojené státy, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Spojené státy, 60657
    - UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
  - Chicago, Illinois, Spojené státy, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Spojené státy, 60611
    - Hematology and Oncology Associates
  - Chicago, Illinois, Spojené státy, 60631
    - Presence Resurrection Medical Center
  - Chicago, Illinois, Spojené státy, 60640
    - Weiss Memorial Hospital
  - Danville, Illinois, Spojené státy, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Spojené státy, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Spojené státy, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Decatur, Illinois, Spojené státy, 62526
    - Heartland Cancer Research NCORP
  - Downers Grove, Illinois, Spojené státy, 60515
    - Advocate Good Samaritan Hospital
  - Effingham, Illinois, Spojené státy, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Spojené státy, 62401
    - Carle Physician Group-Effingham
  - Elmhurst, Illinois, Spojené státy, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, Spojené státy, 61530
    - Illinois CancerCare-Eureka
  - Eureka, Illinois, Spojené státy, 61530
    - Eureka Hospital
  - Evanston, Illinois, Spojené státy, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Spojené státy, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Spojené státy, 61401
    - Illinois CancerCare-Galesburg
  - Galesburg, Illinois, Spojené státy, 61401
    - Galesburg Cottage Hospital
  - Glenview, Illinois, Spojené státy, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Harvey, Illinois, Spojené státy, 60426
    - Ingalls Memorial Hospital
  - Havana, Illinois, Spojené státy, 62644
    - Mason District Hospital
  - Havana, Illinois, Spojené státy, 62644
    - Illinois CancerCare-Havana
  - Highland Park, Illinois, Spojené státy, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Highland Park, Illinois, Spojené státy, 60035
    - Hematology Oncology Associates of Illinois-Highland Park
  - Hinsdale, Illinois, Spojené státy, 60521
    - Hinsdale Hematology Oncology Associates Incorporated
  - Hopedale, Illinois, Spojené státy, 61747
    - Hopedale Medical Complex - Hospital
  - Joliet, Illinois, Spojené státy, 60435
    - Duly Health and Care Joliet
  - Joliet, Illinois, Spojené státy, 60432
    - Midwest Center for Hematology Oncology
  - Kankakee, Illinois, Spojené státy, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Spojené státy, 61443
    - Illinois CancerCare-Kewanee Clinic
  - La Grange, Illinois, Spojené státy, 60525
    - AMITA Health Adventist Medical Center
  - Libertyville, Illinois, Spojené státy, 60048
    - AMG Libertyville - Oncology
  - Macomb, Illinois, Spojené státy, 61455
    - Illinois CancerCare-Macomb
  - Macomb, Illinois, Spojené státy, 61455
    - Mcdonough District Hospital
  - Mattoon, Illinois, Spojené státy, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Spojené státy, 60153
    - Loyola University Medical Center
  - Moline, Illinois, Spojené státy, 61265
    - Garneau, Stewart C MD (UIA Investigator)
  - Moline, Illinois, Spojené státy, 61265
    - Porubcin, Michael MD (UIA Investigator)
  - Moline, Illinois, Spojené státy, 61265
    - Spector, David MD (UIA Investigator)
  - Moline, Illinois, Spojené státy, 61265
    - Trinity Medical Center
  - Monmouth, Illinois, Spojené státy, 61462
    - Illinois CancerCare-Monmouth
  - Monmouth, Illinois, Spojené státy, 61462
    - Holy Family Medical Center
  - Mount Vernon, Illinois, Spojené státy, 62864
    - SSM Health Good Samaritan
  - Niles, Illinois, Spojené státy, 60714
    - Illinois Cancer Specialists-Niles
  - Normal, Illinois, Spojené státy, 61761
    - Carle Cancer Institute Normal
  - Normal, Illinois, Spojené státy, 61761
    - Illinois CancerCare-Community Cancer Center
  - Normal, Illinois, Spojené státy, 61761
    - Carle BroMenn Medical Center
  - Ottawa, Illinois, Spojené státy, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Spojené státy, 61350
    - Radiation Oncology of Northern Illinois
  - Ottawa, Illinois, Spojené státy, 61350
    - Ottawa Regional Hospital and Healthcare Center
  - Pekin, Illinois, Spojené státy, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Spojené státy, 61554
    - Pekin Hospital
  - Pekin, Illinois, Spojené státy, 61554
    - OSF Saint Francis Radiation Oncology at Pekin
  - Peoria, Illinois, Spojené státy, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Spojené státy, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Spojené státy, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Spojené státy, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peoria, Illinois, Spojené státy, 61614
    - Proctor Hospital
  - Peru, Illinois, Spojené státy, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Spojené státy, 61354
    - Valley Radiation Oncology
  - Peru, Illinois, Spojené státy, 61354
    - Illinois Valley Hospital
  - Princeton, Illinois, Spojené státy, 61356
    - Illinois CancerCare-Princeton
  - Princeton, Illinois, Spojené státy, 61356
    - Perry Memorial Hospital
  - River Forest, Illinois, Spojené státy, 60305
    - West Suburban Medical Center
  - Rockford, Illinois, Spojené státy, 61104
    - Swedish American Hospital
  - Rockford, Illinois, Spojené státy, 61114
    - UW Health Carbone Cancer Center Rockford
  - Skokie, Illinois, Spojené státy, 60076
    - Hematology Oncology Associates of Illinois - Skokie
  - Spring Valley, Illinois, Spojené státy, 61362
    - Saint Margaret's Hospital
  - Spring Valley, Illinois, Spojené státy, 61362
    - Illinois CancerCare-Spring Valley
  - Springfield, Illinois, Spojené státy, 62702
    - Central Illinois Hematology Oncology Center
  - Springfield, Illinois, Spojené státy, 62781
    - Springfield Memorial Hospital
  - Urbana, Illinois, Spojené státy, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Spojené státy, 61801
    - The Carle Foundation Hospital
  - Yorkville, Illinois, Spojené státy, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Elkhart, Indiana, Spojené státy, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Spojené státy, 46514
    - Michiana Hematology Oncology PC-Elkhart
  - Elkhart, Indiana, Spojené státy, 46514-2098
    - Elkhart Clinic
  - Fort Wayne, Indiana, Spojené státy, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Indianapolis, Indiana, Spojené státy, 46260
    - Ascension Saint Vincent Indianapolis Hospital
  - Indianapolis, Indiana, Spojené státy, 46202
    - Sidney and Lois Eskenazi Hospital
  - Kokomo, Indiana, Spojené státy, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Spojené státy, 46350
    - IU Health La Porte Hospital
  - Lafayette, Indiana, Spojené státy, 47904
    - IU Health Arnett Cancer Care
  - Michigan City, Indiana, Spojené státy, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Michigan City, Indiana, Spojené státy, 46360
    - Woodland Cancer Care Center
  - Mishawaka, Indiana, Spojené státy, 46545
    - Memorial Regional Cancer Center Day Road
  - Mishawaka, Indiana, Spojené státy, 46545
    - Michiana Hematology Oncology PC-Mishawaka
  - Mishawaka, Indiana, Spojené státy, 46545
    - Cancer Care Partners LLC
  - Mishawaka, Indiana, Spojené státy, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Muncie, Indiana, Spojené státy, 47303
    - IU Health Ball Memorial Hospital
  - Plymouth, Indiana, Spojené státy, 46563
    - Michiana Hematology Oncology PC-Plymouth
  - South Bend, Indiana, Spojené státy, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Spojené státy, 46628
    - Northern Indiana Cancer Research Consortium
  - South Bend, Indiana, Spojené státy, 46617
    - South Bend Clinic
  - Westville, Indiana, Spojené státy, 46391
    - Michiana Hematology Oncology PC-Westville
- Iowa
  - Ames, Iowa, Spojené státy, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Spojené státy, 50010
    - McFarland Clinic - Ames
  - Bettendorf, Iowa, Spojené státy, 52722
    - Constantinou, Costas L MD (UIA Investigator)
  - Bettendorf, Iowa, Spojené státy, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Boone, Iowa, Spojené státy, 50036
    - McFarland Clinic - Boone
  - Cedar Rapids, Iowa, Spojené státy, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Spojené státy, 52403
    - Oncology Associates at Mercy Medical Center
  - Clive, Iowa, Spojené státy, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Spojené státy, 50325
    - UI Health Care Mission Cancer and Blood - West Des Moines Clinic
  - Council Bluffs, Iowa, Spojené státy, 51503
    - Alegent Health Mercy Hospital
  - Des Moines, Iowa, Spojené státy, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Spojené státy, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Spojené státy, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Spojené státy, 50309
    - Iowa-Wide Oncology Research Coalition NCORP
  - Des Moines, Iowa, Spojené státy, 50307
    - Mercy Capitol
  - Des Moines, Iowa, Spojené státy, 50309
    - UI Health Care Mission Cancer and Blood - Des Moines Clinic
  - Des Moines, Iowa, Spojené státy, 50314
    - UI Health Care Mission Cancer and Blood - Laurel Clinic
  - Fort Dodge, Iowa, Spojené státy, 50501
    - McFarland Clinic - Trinity Cancer Center
  - Iowa City, Iowa, Spojené státy, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Jefferson, Iowa, Spojené státy, 50129
    - McFarland Clinic - Jefferson
  - Marshalltown, Iowa, Spojené státy, 50158
    - McFarland Clinic - Marshalltown
  - Mason City, Iowa, Spojené státy, 50401
    - Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, Spojené státy, 52501
    - Ottumwa Regional Health Center
  - Sioux City, Iowa, Spojené státy, 51101
    - Siouxland Regional Cancer Center
  - Sioux City, Iowa, Spojené státy, 51102
    - Mercy Medical Center-Sioux City
  - Sioux City, Iowa, Spojené státy, 51104
    - Saint Luke's Regional Medical Center
  - West Des Moines, Iowa, Spojené státy, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Spojené státy, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Spojené státy, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Spojené státy, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Spojené státy, 67042
    - Cancer Center of Kansas - El Dorado
  - Fort Scott, Kansas, Spojené státy, 66701
    - Cancer Center of Kansas - Fort Scott
  - Independence, Kansas, Spojené státy, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Spojené státy, 66112
    - Providence Medical Center
  - Kingman, Kansas, Spojené státy, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Spojené státy, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Spojené státy, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Spojené státy, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Spojené státy, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Spojené státy, 67114
    - Cancer Center of Kansas - Newton
  - Overland Park, Kansas, Spojené státy, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Spojené státy, 66213
    - Saint Luke's South Hospital
  - Parsons, Kansas, Spojené státy, 67357
    - Cancer Center of Kansas - Parsons
  - Prairie Village, Kansas, Spojené státy, 66208
    - Kansas City NCI Community Oncology Research Program
  - Pratt, Kansas, Spojené státy, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Spojené státy, 67401
    - Cancer Center of Kansas - Salina
  - Shawnee Mission, Kansas, Spojené státy, 66204
    - AdventHealth Shawnee Mission
  - Wellington, Kansas, Spojené státy, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Spojené státy, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Spojené státy, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Spojené státy, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Spojené státy, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Spojené státy, 67214
    - Wichita NCI Community Oncology Research Program
  - Wichita, Kansas, Spojené státy, 67214
    - Wesley Medical Center
  - Winfield, Kansas, Spojené státy, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Ashland, Kentucky, Spojené státy, 41101
    - Our Lady Bellefonte Hospital
  - Bardstown, Kentucky, Spojené státy, 40004
    - CommonSpirit Saint Joseph Hospital - Bardstown
  - Corbin, Kentucky, Spojené státy, 40701
    - Commonwealth Cancer Center-Corbin
  - Lexington, Kentucky, Spojené státy, 40536
    - University of Kentucky/Markey Cancer Center
  - Lexington, Kentucky, Spojené státy, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Spojené státy, 40509
    - CommonSpirit Saint Joseph Medical Center - East Lexington
  - Louisville, Kentucky, Spojené státy, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Spojené státy, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, Spojené státy, 40215
    - Saints Mary and Elizabeth Hospital
  - Shepherdsville, Kentucky, Spojené státy, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Baton Rouge, Louisiana, Spojené státy, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Spojené státy, 70806
    - Baton Rouge General Medical Center
  - Baton Rouge, Louisiana, Spojené státy, 70809
    - Hematology/Oncology Clinic PLLC
  - Marrero, Louisiana, Spojené státy, 70072
    - West Jefferson Medical Center
  - Metairie, Louisiana, Spojené státy, 70006
    - Robert Veith MD LLC
  - Monroe, Louisiana, Spojené státy, 71202
    - Ochsner LSU Health Monroe Medical Center
  - New Orleans, Louisiana, Spojené státy, 70112
    - Tulane University School of Medicine
  - New Orleans, Louisiana, Spojené státy, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Spojené státy, 70112
    - Louisiana State University Health Science Center
  - Shreveport, Louisiana, Spojené státy, 71103
    - LSU Health Sciences Center at Shreveport
  - Shreveport, Louisiana, Spojené státy, 71105
    - Highland Clinic
- Maine
  - Augusta, Maine, Spojené státy, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Spojené státy, 04401
    - Eastern Maine Medical Center
- Maryland
  - Baltimore, Maryland, Spojené státy, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Spojené státy, 21204
    - Greater Baltimore Medical Center
  - Elkton, Maryland, Spojené státy, 21921
    - Christiana Care - Union Hospital
  - Frederick, Maryland, Spojené státy, 21701
    - Frederick Memorial Hospital
- Massachusetts
  - Attleboro, Massachusetts, Spojené státy, 02703
    - Sturdy Memorial Hospital
  - Beverly, Massachusetts, Spojené státy, 01915
    - Beverly Hospital
  - Boston, Massachusetts, Spojené státy, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Spojené státy, 02118
    - Boston Medical Center
  - Gloucester, Massachusetts, Spojené státy, 01930
    - Addison Gilbert Hospital
  - Methuen, Massachusetts, Spojené státy, 01844
    - Holy Family Hospital
  - Pittsfield, Massachusetts, Spojené státy, 01201
    - Berkshire Medical Center - Cancer Center
  - Springfield, Massachusetts, Spojené státy, 01199
    - Baystate Medical Center
- Michigan
  - Ann Arbor, Michigan, Spojené státy, 48106
    - Michigan Cancer Research Consortium NCORP
  - Ann Arbor, Michigan, Spojené státy, 48109
    - University of Michigan Rogel Cancer Center
  - Ann Arbor, Michigan, Spojené státy, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, Spojené státy, 49017
    - Bronson Battle Creek
  - Big Rapids, Michigan, Spojené státy, 49307
    - Spectrum Health Big Rapids Hospital
  - Dearborn, Michigan, Spojené státy, 48124
    - Corewell Health Dearborn Hospital
  - Detroit, Michigan, Spojené státy, 48236
    - Henry Ford Health Saint John Hospital
  - Escanaba, Michigan, Spojené státy, 49829
    - OSF Saint Francis Hospital and Medical Group
  - Farmington Hills, Michigan, Spojené státy, 48336
    - Corewell Health Farmington Hills Hospital
  - Flint, Michigan, Spojené státy, 48532
    - Genesys Regional Medical Center-West Flint Campus
  - Flint, Michigan, Spojené státy, 48503
    - Hurley Medical Center
  - Flint, Michigan, Spojené státy, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Spojené státy, 49503
    - Cancer Research Consortium of West Michigan NCORP
  - Grand Rapids, Michigan, Spojené státy, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, Spojené státy, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Jackson, Michigan, Spojené státy, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Spojené státy, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Spojené státy, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Spojené státy, 49048
    - Beacon Kalamazoo
  - Lansing, Michigan, Spojené státy, 48912
    - University of Michigan Health - Sparrow Lansing
  - Livonia, Michigan, Spojené státy, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Marquette, Michigan, Spojené státy, 49855
    - UP Health System Marquette
  - Muskegon, Michigan, Spojené státy, 49442
    - Mercy Health Partners-Hackley Campus
  - Muskegon, Michigan, Spojené státy, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, Spojené státy, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Pontiac, Michigan, Spojené státy, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Port Huron, Michigan, Spojené státy, 48060
    - Lake Huron Medical Center
  - Reed City, Michigan, Spojené státy, 49677
    - Corewell Health Reed City Hospital
  - Royal Oak, Michigan, Spojené státy, 48073
    - Corewell Health William Beaumont University Hospital
  - Saginaw, Michigan, Spojené státy, 48601
    - MyMichigan Medical Center Saginaw
  - Saint Joseph, Michigan, Spojené státy, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Spojené státy, 49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Traverse City, Michigan, Spojené státy, 49684
    - Munson Medical Center
  - Troy, Michigan, Spojené státy, 48085
    - Corewell Health Beaumont Troy Hospital
  - Warren, Michigan, Spojené státy, 48093
    - Henry Ford Health Warren Hospital
  - Wyoming, Michigan, Spojené státy, 49519
    - University of Michigan Health - West
- Minnesota
  - Alexandria, Minnesota, Spojené státy, 56308
    - Medini, Eitan MD (UIA Investigator)
  - Brainerd, Minnesota, Spojené státy, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Spojené státy, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Spojené státy, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Spojené státy, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Spojené státy, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Spojené státy, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Spojené státy, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, Spojené státy, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Spojené státy, 55350
    - Hutchinson Area Health Care
  - Maplewood, Minnesota, Spojené státy, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Spojené státy, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Spojené státy, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Spojené státy, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Spojené státy, 55454
    - Health Partners Inc
  - New Ulm, Minnesota, Spojené státy, 56073
    - New Ulm Medical Center
  - Robbinsdale, Minnesota, Spojené státy, 55422
    - North Memorial Medical Health Center
  - Saint Cloud, Minnesota, Spojené státy, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Cloud, Minnesota, Spojené státy, 56303
    - Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Spojené státy, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Spojené státy, 55416
    - Metro Minnesota Community Oncology Research Consortium
  - Saint Paul, Minnesota, Spojené státy, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Spojené státy, 55102
    - United Hospital
  - Shakopee, Minnesota, Spojené státy, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Spojené státy, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Spojené státy, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Spojené státy, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Spojené státy, 55125
    - Minnesota Oncology Hematology PA-Woodbury
- Mississippi
  - Gulfport, Mississippi, Spojené státy, 39502
    - Gulfport Memorial Hospital
  - Hattiesburg, Mississippi, Spojené státy, 39401
    - Hattiesburg Clinic - Hematology/Oncology Clinic
  - Hattiesburg, Mississippi, Spojené státy, 39404
    - Forrest General Hospital / Cancer Center
  - Jackson, Mississippi, Spojené státy, 39216
    - University of Mississippi Medical Center
  - Pascagoula, Mississippi, Spojené státy, 39581
    - Singing River Hospital
- Missouri
  - Bolivar, Missouri, Spojené státy, 65613
    - Central Care Cancer Center - Bolivar
  - Bonne Terre, Missouri, Spojené státy, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Spojené státy, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Spojené státy, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Spojené státy, 63701
    - Southeast Missouri Hospital
  - Cape Girardeau, Missouri, Spojené státy, 63703
    - Mercy Cancer Center - Cape Girardeau
  - Columbia, Missouri, Spojené státy, 65201
    - Veterans Administration
  - Columbia, Missouri, Spojené státy, 65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Independence, Missouri, Spojené státy, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Spojené státy, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, Spojené státy, 64804
    - Freeman Health System
  - Joplin, Missouri, Spojené státy, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Spojené státy, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Spojené státy, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Spojené státy, 64132
    - Research Medical Center
  - Kansas City, Missouri, Spojené státy, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Kansas City, Missouri, Spojené státy, 64114
    - Saint Joseph Health Center
  - Kansas City, Missouri, Spojené státy, 64108
    - University Health Truman Medical Center
  - Lee's Summit, Missouri, Spojené státy, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Spojené státy, 64068
    - Liberty Hospital
  - Rolla, Missouri, Spojené státy, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla, Missouri, Spojené státy, 65401
    - Phelps Health Delbert Day Cancer Institute
  - Saint Joseph, Missouri, Spojené státy, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, Spojené státy, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Spojené státy, 65804
    - Cancer Research for the Ozarks NCORP
  - Springfield, Missouri, Spojené státy, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Spojené státy, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Spojené státy, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Spojené státy, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Spojené státy, 63104
    - SSM Health Saint Louis University Hospital
  - St Louis, Missouri, Spojené státy, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Spojené státy, 63141
    - Comprehensive Cancer Care PC
  - St Louis, Missouri, Spojené státy, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Spojené státy, 63141
    - Center for Cancer Care and Research
  - Sullivan, Missouri, Spojené státy, 63080
    - Missouri Baptist Sullivan Hospital
- Montana
  - Billings, Montana, Spojené státy, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Spojené státy, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Spojené státy, 59102
    - Montana Cancer Consortium NCORP
  - Billings, Montana, Spojené státy, 59101
    - Northern Rockies Radiation Oncology Center
  - Billings, Montana, Spojené státy, 59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman, Montana, Spojené státy, 59715
    - Bozeman Health Deaconess Hospital
  - Butte, Montana, Spojené státy, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Spojené státy, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Spojené státy, 59405
    - Berdeaux, Donald MD (UIA Investigator)
  - Great Falls, Montana, Spojené státy, 59405
    - Benefis Sletten Cancer Institute
  - Havre, Montana, Spojené státy, 59501
    - Northern Montana Hospital
  - Helena, Montana, Spojené státy, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Spojené státy, 59901
    - Glacier Oncology PLLC
  - Kalispell, Montana, Spojené státy, 59901
    - Kalispell Medical Oncology
  - Kalispell, Montana, Spojené státy, 59901
    - Logan Health Medical Center
  - Missoula, Montana, Spojené státy, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Spojené státy, 59804
    - Guardian Oncology and Center for Wellness
  - Missoula, Montana, Spojené státy, 59802
    - Montana Cancer Specialists
  - Missoula, Montana, Spojené státy, 59804
    - Community Medical Center
- Nebraska
  - Grand Island, Nebraska, Spojené státy, 68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney, Nebraska, Spojené státy, 68847
    - CHI Health Good Samaritan
  - Kearney, Nebraska, Spojené státy, 68845
    - Fred and Pamela Buffett Cancer Center - Kearney
  - Lincoln, Nebraska, Spojené státy, 68506
    - Nebraska Hematology and Oncology
  - Lincoln, Nebraska, Spojené státy, 68510
    - Nebraska Cancer Research Center
  - Lincoln, Nebraska, Spojené státy, 68510
    - Saint Elizabeth Regional Medical Center
  - Lincoln, Nebraska, Spojené státy, 68516
    - Cancer Partners of Nebraska
  - Norfolk, Nebraska, Spojené státy, 68701
    - Faith Regional Health Services Carson Cancer Center
  - North Platte, Nebraska, Spojené státy, 69101
    - Great Plains Health Callahan Cancer Center
  - Omaha, Nebraska, Spojené státy, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Spojené státy, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Spojené státy, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Spojené státy, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Spojené státy, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Spojené státy, 68106
    - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, Spojené státy, 68124
    - Nebraska Cancer Specialists - Omaha
  - Omaha, Nebraska, Spojené státy, 68130
    - Oncology Hematology West PC
  - Omaha, Nebraska, Spojené státy, 68130
    - Urology Cancer Center PC
  - Omaha, Nebraska, Spojené státy, 68122
    - Hematology and Oncology Consultants PC
  - Papillion, Nebraska, Spojené státy, 68046
    - Midlands Community Hospital
  - Scottsbluff, Nebraska, Spojené státy, 69361
    - Regional West Medical Center Cancer Center
- Nevada
  - Henderson, Nevada, Spojené státy, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Spojené státy, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Spojené státy, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Spojené státy, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Spojené státy, 89074
    - Oncology Las Vegas - Henderson
  - Las Vegas, Nevada, Spojené státy, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Spojené státy, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Spojené státy, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Spojené státy, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Spojené státy, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Spojené státy, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Spojené státy, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Spojené státy, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Spojené státy, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Spojené státy, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Spojené státy, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Spojené státy, 89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas, Nevada, Spojené státy, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Spojené státy, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Spojené státy, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Spojené státy, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Spojené státy, 89120
    - Nevada Cancer Research Foundation NCORP
  - Las Vegas, Nevada, Spojené státy, 89128
    - Oncology Las Vegas - Tenaya
  - Las Vegas, Nevada, Spojené státy, 89183
    - OptumCare Cancer Care at Fort Apache
  - Reno, Nevada, Spojené státy, 89502
    - Renown Regional Medical Center
- New Jersey
  - Camden, New Jersey, Spojené státy, 08103
    - Cooper Hospital University Medical Center
  - East Orange, New Jersey, Spojené státy, 07018-1095
    - Veterans Adminstration New Jersey Health Care System
  - Hackensack, New Jersey, Spojené státy, 07601
    - Hackensack University Medical Center
  - Morristown, New Jersey, Spojené státy, 07960
    - Morristown Medical Center
  - Mullica Hill, New Jersey, Spojené státy, 08062
    - Inspira Medical Center Mullica Hill
  - Newark, New Jersey, Spojené státy, 07101
    - Rutgers New Jersey Medical School
  - Newark, New Jersey, Spojené státy, 07112
    - Newark Beth Israel Medical Center
  - Summit, New Jersey, Spojené státy, 07902
    - Overlook Hospital
  - Vineland, New Jersey, Spojené státy, 08360
    - Inspira Medical Center Vineland
- New Mexico
  - Albuquerque, New Mexico, Spojené státy, 87102
    - Lovelace Medical Center-Saint Joseph Square
  - Albuquerque, New Mexico, Spojené státy, 87106
    - University of New Mexico Cancer Center
  - Las Cruces, New Mexico, Spojené státy, 88011
    - Memorial Medical Center-Las Cruces
- New York
  - Auburn, New York, Spojené státy, 13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Brooklyn, New York, Spojené státy, 11203
    - Kings County Hospital
  - Brooklyn, New York, Spojené státy, 11209
    - Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
  - Brooklyn, New York, Spojené státy, 11203
    - State University of New York Downstate Medical Center
  - Buffalo, New York, Spojené státy, 14215
    - Veterans Affairs Western New York Health Care System-Buffalo
  - Camillus, New York, Spojené státy, 13031
    - Hematology Oncology Associates of CNY at Camillus
  - Cooperstown, New York, Spojené státy, 13326
    - Mary Imogene Bassett Hospital
  - East Syracuse, New York, Spojené státy, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Glens Falls, New York, Spojené státy, 12801
    - Glens Falls Hospital
  - Middletown, New York, Spojené státy, 10940
    - Garnet Health Medical Center
  - New York, New York, Spojené státy, 10065
    - NYP/Weill Cornell Medical Center
  - New York, New York, Spojené státy, 10003
    - Mount Sinai Union Square
  - The Bronx, New York, Spojené státy, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Spojené státy, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Utica, New York, Spojené státy, 13502
    - Faxton-Saint Luke's Healthcare
- North Carolina
  - Charlotte, North Carolina, Spojené státy, 28204
    - Novant Health Presbyterian Medical Center
  - Charlotte, North Carolina, Spojené státy, 28207
    - Oncology Specialists of Charlotte
  - Charlotte, North Carolina, Spojené státy, 28262
    - Southern Oncology Specialists-Charlotte
  - Charlotte, North Carolina, Spojené státy, 28207
    - Novant Health Carolina Surgical - Randolph
  - Clinton, North Carolina, Spojené státy, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Goldsboro, North Carolina, Spojené státy, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Spojené státy, 27534
    - Wayne Memorial Hospital
  - Huntersville, North Carolina, Spojené státy, 28078
    - Novant Health Cancer Institute - Huntersville
  - Huntersville, North Carolina, Spojené státy, 28078
    - Southern Oncology Specialists-Huntersville
  - Jacksonville, North Carolina, Spojené státy, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Kinston, North Carolina, Spojené státy, 28501
    - ECU Health Oncology Kinston
  - Matthews, North Carolina, Spojené státy, 28105
    - Matthews Radiation Oncology Center
  - Matthews, North Carolina, Spojené státy, 28105
    - Novant Health Cancer Institute - Matthews
  - Mooresville, North Carolina, Spojené státy, 28117
    - Novant Health Cancer Institute - Mooresville
- North Dakota
  - Bismarck, North Dakota, Spojené státy, 58501
    - Sanford Bismarck Medical Center
  - Bismarck, North Dakota, Spojené státy, 58501
    - Mid Dakota Clinic
  - Bismarck, North Dakota, Spojené státy, 58501
    - Saint Alexius Medical Center
  - Grand Forks, North Dakota, Spojené státy, 58201
    - Altru Cancer Center
  - Minot, North Dakota, Spojené státy, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Spojené státy, 44307
    - Cleveland Clinic Akron General
  - Akron, Ohio, Spojené státy, 44304
    - Summa Health System - Akron Campus
  - Barberton, Ohio, Spojené státy, 44203
    - Summa Health System - Barberton Campus
  - Beachwood, Ohio, Spojené státy, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Bellefontaine, Ohio, Spojené státy, 43311
    - Mary Rutan Hospital
  - Belpre, Ohio, Spojené státy, 45714
    - Strecker Cancer Center-Belpre
  - Canton, Ohio, Spojené státy, 44708
    - Cleveland Clinic Mercy Hospital
  - Canton, Ohio, Spojené státy, 44710
    - Aultman Health Foundation
  - Chillicothe, Ohio, Spojené státy, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Spojené státy, 45219
    - University of Cincinnati Cancer Center-UC Medical Center
  - Cincinnati, Ohio, Spojené státy, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Spojené státy, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Spojené státy, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Spojené státy, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Spojené státy, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Spojené státy, 44109
    - MetroHealth Medical Center
  - Columbus, Ohio, Spojené státy, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Spojené státy, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Spojené státy, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Spojené státy, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Spojené státy, 43228
    - Doctors Hospital
  - Columbus, Ohio, Spojené státy, 43215
    - Grant Medical Center
  - Columbus, Ohio, Spojené státy, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Spojené státy, 43215
    - Columbus NCI Community Oncology Research Program
  - Dayton, Ohio, Spojené státy, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Spojené státy, 45428
    - Dayton Veterans Affairs Medical Center
  - Delaware, Ohio, Spojené státy, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Spojené státy, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Spojené státy, 43015
    - Grady Memorial Hospital
  - Greenville, Ohio, Spojené státy, 45331
    - Wayne Hospital
  - Lancaster, Ohio, Spojené státy, 43130
    - Fairfield Medical Center
  - Lancaster, Ohio, Spojené státy, 43130
    - Lancaster Radiation Oncology
  - Lima, Ohio, Spojené státy, 45801
    - Saint Rita's Medical Center
  - Marietta, Ohio, Spojené státy, 45750
    - Marietta Memorial Hospital
  - Mayfield Heights, Ohio, Spojené státy, 44124
    - UH Seidman Cancer Center at Landerbrook Health Center
  - Mentor, Ohio, Spojené státy, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Mount Vernon, Ohio, Spojené státy, 43050
    - Knox Community Hospital
  - Newark, Ohio, Spojené státy, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Spojené státy, 43055
    - Newark Radiation Oncology
  - Portsmouth, Ohio, Spojené státy, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Spojené státy, 44870
    - UH Seidman Cancer Center at Firelands Regional Medical Center
  - Springfield, Ohio, Spojené státy, 45504
    - Springfield Regional Medical Center
  - Troy, Ohio, Spojené státy, 45373
    - Upper Valley Medical Center
  - Westerville, Ohio, Spojené státy, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Spojené státy, 44145
    - UHHS-Westlake Medical Center
  - Zanesville, Ohio, Spojené státy, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Oklahoma City, Oklahoma, Spojené státy, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Spojené státy, 73109
    - Integris Southwest Medical Center
  - Oklahoma City, Oklahoma, Spojené státy, 73142
    - Integris Cancer Institute of Oklahoma
  - Oklahoma City, Oklahoma, Spojené státy, 73120
    - Cancer Care Associates
  - Tulsa, Oklahoma, Spojené státy, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
- Oregon
  - Salem, Oregon, Spojené státy, 97301
    - Salem Hospital
- Pennsylvania
  - Allentown, Pennsylvania, Spojené státy, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Beaver, Pennsylvania, Spojené státy, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem, Pennsylvania, Spojené státy, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bethlehem, Pennsylvania, Spojené státy, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Danville, Pennsylvania, Spojené státy, 17822
    - Geisinger Medical Center
  - Drexel Hill, Pennsylvania, Spojené státy, 19026
    - Delaware County Memorial Hospital
  - East Stroudsburg, Pennsylvania, Spojené státy, 18301
    - Pocono Medical Center
  - Greensburg, Pennsylvania, Spojené státy, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Hazleton, Pennsylvania, Spojené státy, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Johnstown, Pennsylvania, Spojené státy, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Lewisburg, Pennsylvania, Spojené státy, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Spojené státy, 17044
    - Lewistown Hospital
  - McKeesport, Pennsylvania, Spojené státy, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Media, Pennsylvania, Spojené státy, 19063
    - Riddle Memorial Hospital
  - Moon Township, Pennsylvania, Spojené státy, 15108
    - UPMC Hillman Cancer Center in Coraopolis
  - Philadelphia, Pennsylvania, Spojené státy, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Spojené státy, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Spojené státy, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Spojené státy, 19140
    - Temple University Hospital
  - Pittsburgh, Pennsylvania, Spojené státy, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Spojené státy, 15232
    - UPMC Hillman Cancer Center
  - Pittsburgh, Pennsylvania, Spojené státy, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Spojené státy, 15232
    - UPMC-Shadyside Hospital
  - Pittsburgh, Pennsylvania, Spojené státy, 15213
    - UPMC-Presbyterian Hospital
  - Pittsburgh, Pennsylvania, Spojené státy, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Spojené státy, 15236
    - UPMC Jefferson Regional Radiation Oncology
  - Pittsburgh, Pennsylvania, Spojené státy, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Spojené státy, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pittsburgh, Pennsylvania, Spojené státy, 15240
    - VA Pittsburgh Healthcare System
  - Pottsville, Pennsylvania, Spojené státy, 17901
    - Geisinger Cancer Services-Pottsville
  - Reading, Pennsylvania, Spojené státy, 19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre, Pennsylvania, Spojené státy, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton, Pennsylvania, Spojené státy, 18510
    - Scranton Hematology Oncology
  - Scranton, Pennsylvania, Spojené státy, 18501
    - Mercy Hospital
  - Scranton, Pennsylvania, Spojené státy, 18508
    - Hematology and Oncology Associates of North East Pennsylvania
  - Seneca, Pennsylvania, Spojené státy, 16346
    - UPMC Cancer Center at UPMC Northwest
  - State College, Pennsylvania, Spojené státy, 16801
    - Geisinger Medical Group
  - Uniontown, Pennsylvania, Spojené státy, 15401
    - UPMC Uniontown Hospital Radiation Oncology
  - Upland, Pennsylvania, Spojené státy, 19013
    - Associates In Hematology Oncology PC-Upland
  - Washington, Pennsylvania, Spojené státy, 15301
    - UPMC Washington Hospital Radiation Oncology
  - West Chester, Pennsylvania, Spojené státy, 19380
    - Chester County Hospital
  - West Reading, Pennsylvania, Spojené státy, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Spojené státy, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Spojené státy, 17701
    - UPMC Susquehanna
- Rhode Island
  - Pawtucket, Rhode Island, Spojené státy, 02860
    - Memorial Hospital of Rhode Island
  - Providence, Rhode Island, Spojené státy, 02908
    - Roger Williams Medical Center
- South Carolina
  - Boiling Springs, South Carolina, Spojené státy, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Easley, South Carolina, Spojené státy, 29640
    - Prisma Health Cancer Institute - Easley
  - Florence, South Carolina, Spojené státy, 29506
    - McLeod Regional Medical Center
  - Greenville, South Carolina, Spojené státy, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Spojené státy, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Spojené státy, 29605
    - Prisma Health Greenville Memorial Hospital
  - Greenville, South Carolina, Spojené státy, 29601
    - Greenville Health System Cancer Institute-Andrews
  - Greenwood, South Carolina, Spojené státy, 29646
    - Self Regional Healthcare
  - Greer, South Carolina, Spojené státy, 29650
    - Prisma Health Cancer Institute - Greer
  - Seneca, South Carolina, Spojené státy, 29672
    - Prisma Health Cancer Institute - Seneca
- South Dakota
  - Rapid City, South Dakota, Spojené státy, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Spojené státy, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Spojené státy, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Spojené státy, 57104
    - Sanford Cancer Center Oncology Clinic
  - Sioux Falls, South Dakota, Spojené státy, 57105
    - Medical X-Ray Center
  - Sioux Falls, South Dakota, Spojené státy, 57117-5045
    - Avera McKennan Hospital and University Health Center
- Tennessee
  - Chattanooga, Tennessee, Spojené státy, 37404
    - Memorial Hospital
  - Chattanooga, Tennessee, Spojené státy, 37403
    - Erlanger Medical Center
  - Franklin, Tennessee, Spojené státy, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Hixson, Tennessee, Spojené státy, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Knoxville, Tennessee, Spojené státy, 37920
    - University of Tennessee - Knoxville
  - Nashville, Tennessee, Spojené státy, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Spojené státy, 37208
    - Meharry Medical College
  - Nashville, Tennessee, Spojené státy, 37203
    - Nashville Oncology Associates PC
  - Ooltewah, Tennessee, Spojené státy, 37363
    - Memorial GYN Plus
- Texas
  - Houston, Texas, Spojené státy, 77030
    - Houston Methodist Hospital
  - Houston, Texas, Spojené státy, 77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston, Texas, Spojené státy, 77030
    - Michael E DeBakey VA Medical Center
  - Houston, Texas, Spojené státy, 77030
    - Ben Taub General Hospital
  - Houston, Texas, Spojené státy, 77030
    - Baylor Saint Luke's Medical Center
  - Lubbock, Texas, Spojené státy, 79430
    - Texas Tech University Health Sciences Center-Lubbock
  - San Antonio, Texas, Spojené státy, 78229
    - University Hospital
  - San Antonio, Texas, Spojené státy, 78229
    - University of Texas Health Science Center at San Antonio
  - San Antonio, Texas, Spojené státy, 78229
    - Audie L Murphy VA Hospital
- Utah
  - American Fork, Utah, Spojené státy, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Spojené státy, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Spojené státy, 84321
    - Logan Regional Hospital
  - Murray, Utah, Spojené státy, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Spojené státy, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Spojené státy, 84604
    - Utah Valley Regional Medical Center
  - Salt Lake City, Utah, Spojené státy, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Spojené státy, 84143
    - LDS Hospital
  - St. George, Utah, Spojené státy, 84770
    - Saint George Regional Medical Center
- Virginia
  - Danville, Virginia, Spojené státy, 24541
    - Danville Regional Medical Center
  - Richmond, Virginia, Spojené státy, 23298
    - VCU Massey Comprehensive Cancer Center
- Washington
  - Bellingham, Washington, Spojené státy, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Burien, Washington, Spojené státy, 98166
    - Saint Anne Hospital
  - Enumclaw, Washington, Spojené státy, 98022
    - Saint Elizabeth Hospital
  - Federal Way, Washington, Spojené státy, 98003
    - Saint Francis Hospital
  - Issaquah, Washington, Spojené státy, 98029
    - Swedish Cancer Institute-Issaquah
  - Kirkland, Washington, Spojené státy, 98033
    - EvergreenHealth Medical Center
  - Lakewood, Washington, Spojené státy, 98499
    - Saint Clare Hospital
  - Port Angeles, Washington, Spojené státy, 98362
    - Olympic Medical Center
  - Renton, Washington, Spojené státy, 98055
    - Valley Medical Center
  - Renton, Washington, Spojené státy, 98055
    - Southlake Clinic
  - Seattle, Washington, Spojené státy, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Spojené státy, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Spojené státy, 98104
    - Pacific Medical Center-First Hill
  - Tacoma, Washington, Spojené státy, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Spojené státy, 98405
    - Franciscan Research Center-Northwest Medical Plaza
- West Virginia
  - Charleston, West Virginia, Spojené státy, 25304
    - Vandalia Health/CAMC Institute for Academic Medicine
  - Huntington, West Virginia, Spojené státy, 25701
    - Edwards Comprehensive Cancer Center
  - Morgantown, West Virginia, Spojené státy, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Spojené státy, 26101
    - Camden Clark Medical Center
- Wisconsin
  - Antigo, Wisconsin, Spojené státy, 54409
    - Aspirus Cancer Care-Antigo-Volm Cancer Center
  - Burlington, Wisconsin, Spojené státy, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Spojené státy, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Spojené státy, 54701
    - HSHS Sacred Heart Hospital
  - Eau Claire, Wisconsin, Spojené státy, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Fond du Lac, Wisconsin, Spojené státy, 54937
    - Aurora Health Center-Fond du Lac
  - Green Bay, Wisconsin, Spojené státy, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Spojené státy, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Spojené státy, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Spojené státy, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Johnson Creek, Wisconsin, Spojené státy, 53038
    - University of Wisconsin Carbone Cancer Center - Johnson Creek
  - Kenosha, Wisconsin, Spojené státy, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Spojené státy, 54601
    - Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Spojené státy, 53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Manitowoc, Wisconsin, Spojené státy, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Spojené státy, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, Spojené státy, 54143
    - Bay Area Medical Center
  - Marshfield, Wisconsin, Spojené státy, 54449
    - Marshfield Medical Center-Marshfield
  - Marshfield, Wisconsin, Spojené státy, 54449
    - Marshfield Medical Center
  - Mequon, Wisconsin, Spojené státy, 53097
    - Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
  - Milwaukee, Wisconsin, Spojené státy, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Spojené státy, 53211
    - Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
  - Minocqua, Wisconsin, Spojené státy, 54548
    - Marshfield Medical Center - Minocqua
  - New Richmond, Wisconsin, Spojené státy, 54017
    - Cancer Center of Western Wisconsin
  - Oconto Falls, Wisconsin, Spojené státy, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Spojené státy, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Spojené státy, 53406
    - Aurora Cancer Care-Racine
  - Racine, Wisconsin, Spojené státy, 53405
    - Ascension All Saints Hospital-Spring Street-Racine
  - Rhinelander, Wisconsin, Spojené státy, 54501
    - Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
  - Rice Lake, Wisconsin, Spojené státy, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Spojené státy, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Spojené státy, 53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Spojené státy, 54481
    - Aspirus Cancer Care - Stevens Point
  - Summit, Wisconsin, Spojené státy, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Spojené státy, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Spojené státy, 53188
    - Aurora Cancer Care-Waukesha
  - Wausau, Wisconsin, Spojené státy, 54401
    - Aspirus Cancer Care-Wausau
  - Weston, Wisconsin, Spojené státy, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Spojené státy, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
  - Wisconsin Rapids, Wisconsin, Spojené státy, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Casper, Wyoming, Spojené státy, 82609
    - Rocky Mountain Oncology
  - Cheyenne, Wyoming, Spojené státy, 82001
    - Cheyenne Regional Medical Center-West
  - Sheridan, Wyoming, Spojené státy, 82801
    - Welch Cancer Center

Kritéria účasti

Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.

Kritéria způsobilosti

Věk způsobilý ke studiu

18 let a starší (Dospělý, Starší dospělý)

Přijímá zdravé dobrovolníky

Pohlaví způsobilá ke studiu

Všechno

Popis

Inclusion Criteria:

Patients must have histologically or cytologically confirmed squamous cell cancer of the head and neck (SCCHN), from any primary site, including unknown primary cancers of the head and neck; patient must not have nasopharyngeal carcinoma of histologic types World Health Organization (WHO) 2 or 3 or squamous cell carcinoma that originated in the skin
Patients must have SCCHN that is either (a) recurrent, judged incurable by surgery or radiation or (b) metastatic; NOTE: Patients who refuse radical resection for recurrent disease are eligible; NOTE: A second primary squamous cell carcinoma of the head and neck is allowed if eligibility is based on a recurrent or metastatic first primary squamous cell carcinoma of the head and neck
No prior chemotherapy or biologic/molecular targeted therapy for recurrent or metastatic SCCHN
- Patients may have received one regimen of induction, concomitant chemoradiotherapy and/or adjuvant chemotherapy as part of initial potential curative therapy but must not have received prior chemotherapy for recurrent or metastatic disease
- A minimum of 4 months is required between last dose of chemotherapy or chemoradiotherapy and study treatment; in addition patients must be progression-free for at least 4 months after completion of chemotherapy or chemoradiotherapy or radiation plus cetuximab given with a curative intent; (cetuximab therapy: 4 months is required between last dose of chemotherapy or chemoradiotherapy and study treatment if part of concurrent regimen, 8 weeks if part of adjuvant regimen post radiation)
- Patients having progression after 2 cycles of induction chemotherapy are not eligible for the study
No prior bevacizumab is allowed
A maximum of one prior radiotherapy regimen, curative or palliative, to the head and neck is allowed; if the radiation is combined with chemotherapy and/or cetuximab, a minimum of 4 months must elapse between the end of radiotherapy and registration; if the radiation is given alone, a minimum of 8 weeks must elapse between the end of radiotherapy and registration; a minimum of 3 weeks must elapse between prior radiation to other areas and registration
Patients must not be receiving any other investigational agent while on the study
Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
Patients must have recovered to grade 1 or better from any acute effects of prior surgery, chemotherapy, or radiation therapy, and should be > 4 weeks post surgery; chronic late xerostomia, speech and swallowing abnormalities resulting from prior radiation or surgery are permitted if nutritional status is stable
Patients must have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST); baseline measurements and evaluations of all sites of disease must be obtained =< 4 weeks prior to randomization; disease in previously irradiated sites is considered measurable if there has been unequivocal disease progression or biopsy-proven residual carcinoma following radiation therapy; persistent disease after radiotherapy must be biopsy proven at least 8 weeks after completion of radiation therapy; (radiographic findings are acceptable providing that clear-cut measurements can be made)
Absolute neutrophil count (ANC) >= 1500/mm^3
Hemoglobin (Hgb) >= 8.0 g/dL
Platelet count >= 100,000/mm^3
Creatinine clearance of >= 60 ml/min; creatinine clearance may be measured or calculated; if calculating, creatinine clearance, use the Cockroft-Gault formula
Total bilirubin within normal limits (must be obtained =< 2 weeks prior to randomization)
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) must be within the range allowing for eligibility
- Alkaline phosphatase normal AND AST or ALT =< 5 x upper limit of normal (ULN)
- Alkaline phosphatase > 1 but =< 2.5 x ULN AND AST or ALT > 1 but =< 1.5 x ULN
- Alkaline phosphatase > 2.5 but =< 5 x ULN AND AST or ALT normal
Alkaline phosphatase must be within the range allowing for eligibility
Urine dipstick must be =< 0-1+ within 2 weeks (14 days) of randomization; if urine dipstick result is > 1+, a calculation of urine protein creatinine (UPC) ratio is required; patients must have a UPC ratio < 1.0 to participate in the study; NOTE: UPC ratio of spot urine is an estimation of the 24 urine protein excretion - a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gm
No known brain metastases
Patients who meet the following criteria will be excluded:
- Tumors that invade major vessels (e.g. the carotid) as shown unequivocally by imaging studies
- Central (i.e. within 2 cm from the hilum) lung metastases that are cavitary as shown unequivocally by imaging studies
- Any prior history of bleeding related to the current head and neck cancer
- History of gross hemoptysis (bright red blood of 1/2 teaspoon or more per episode of coughing) =< 3 months prior to enrollment
No history of coagulopathy or hemorrhagic disorders
Patients should not have a history of thrombosis (e.g. pulmonary embolism or deep venous thrombosis) currently requiring therapeutic anticoagulation (prophylactic use of warfarin 1 mg per day is allowed) and international normalized ratio (INR) should be < 1.5 at registration
Patients must not be receiving chronic daily treatment with aspirin (> 325 mg/day) or non-steroidal anti-inflammatory agents (NSAID's) known to inhibit platelet function; the use of anti-platelet agents (e.g. dipyridamole [Persantine], ticlopidine [Ticlid], clopidogrel [Plavix]) is allowed only if patient is not receiving aspirin or NSAID's known to inhibit platelet function
No hypercalcemia related to head and neck cancer
Patients with a prior history of squamous cell or basal carcinoma of the skin or in situ cervical cancer must have been curatively treated; patients with a history of other prior malignancy must have been treated with curative intent and must have remained disease-free for 3 years post diagnosis
No current peripheral neuropathy >= grade 2 at time of randomization
Patients must not have any co-existing condition that would preclude full compliance with the study
No prior history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80, if the physician's choice of chemotherapy regimen is docetaxel
All patients must have blood pressure =< 150/90 =< 2 weeks prior to randomization; patients with history of hypertension must be well-controlled upon study entry (=< 150/90) on a stable regimen of anti-hypertensive therapy
No major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study enrollment, or anticipation of need for major surgical procedure during the course of the study
No unstable angina or myocardial infarction within the previous 6 months; no symptomatic congestive heart failure, New York Heart Association (NYHA) grade II or greater; no history of aortic dissection or presence of aneurysm > 6 cm (or at high risk for rupture); no serious cardiac arrhythmia requiring medication (history of chronic atrial fibrillation or other atrial arrhythmia with controlled rate on medication is allowed); no clinically significant peripheral vascular disease manifested by intermittent claudication or need for vascular intervention; no history of aortic dissection; no history of any central nervous system (CNS) cerebrovascular ischemia or stroke within the last 6 months; no active serious infection
Patients should not have prior history of a serious human anti-human antibody (HAHA) reaction; patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies are not eligible
Women must not be pregnant or breast feeding; pregnant women are excluded from this study; women of child-bearing potential and men must agree to total abstinence or to use adequate hormonal or barrier method of birth control prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while in this study, she should inform her treating physician immediately; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy
Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study; appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicated
No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to registration

Studijní plán

Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.

Jak je studie koncipována?

Detaily designu

Primární účel: Léčba
Přidělení: Randomizované
Intervenční model: Paralelní přiřazení
Maskování: Žádné (otevřený štítek)

Počet zbraní

Zbraně a zásahy

Skupina účastníků / Arm	Intervence / Léčba
Aktivní komparátor: Arm IA (docetaxel, cisplatin) Patients receive docetaxel IV over 1 hour and cisplatin IV over 1-2 hours on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.	Jiný: Laboratory Biomarker Analysis Correlative studies Lék: Cisplatin Given IV Ostatní jména: CDDP Cis-diamindichloridoplatina Cismaplat Cisplatina Neoplatin Platinol Abiplatina Blastolem Briplatina Cis-diamin-dichloroplatina Cis-diamindichloroplatina (II) Cis-diamindichloroplatina Cis-dichlorammin platina (II) Cis-platinový diamindichlorid Cis-platina Cis-platina II Cis-platina II diamindichlorid Cisplatyl Citoplatino Citosin Cysplatyna DDP Lederplatina Metaplatina Peyronův chlorid Peyronova sůl Placis Plastistil Platamin Platiblastin Platiblastin-S Platinex Platinol-AQ Platinol-AQ VHA Plus Platinoxan Platina Diaminodichlorid platiny Platiran Platistin Platosin Lék: Docetaxel Given IV Ostatní jména: Taxotere Docecad RP56976 Injekční koncentrát Taxotere RP 56976 RP-56976
Experimentální: Arm IB (docetaxel, cisplatin, bevacizumab) Patients receive bevacizumab IV over 30-90 minutes on day 1 and docetaxel and cisplatin as in Arm IA.	Jiný: Laboratory Biomarker Analysis Correlative studies Biologický: Bevacizumab Given IV Ostatní jména: Avastin ABP 215 Anti-VEGF Anti-VEGF humanizovaná monoklonální protilátka Monoklonální protilátka proti VEGF SIBP04 Anti-VEGF rhuMAb Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Imunoglobulin G1 (lidský-myší monoklonální rhuMab-VEGF gama-řetězcový anti-lidský vaskulární endoteliální růstový faktor), disulfid s lidským-myším monoklonálním lehkým řetězcem rhuMab-VEGF, dimer Mvasi MYL-1402O Rekombinantní humanizovaná anti-VEGF monoklonální protilátka rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev Avegra QL1101 IBI305 Byvasda Bevacizumab Biosimilar QL1101 BAT1706 BAT 1706 BAT-1706 BAT1706 Biosimilar Bevacizumab Biosimilar BAT1706 Bevacizumab-adcd CT-P16 Vegzelma Alymsys ABP-215 ABP215 Aybintio Bevacizumab-aybi Bevacizumab-ekvi Bevacizumab-maly Bevacizumab-onbe ČT P16 CTP16 Ekvidacentní Onbevzi Avzivi Bevacizumab Biosimilar MB02 Bevacizumab-tnjn FKB 238 FKB-238 FKB238 MB 02 MB-02 MB02 Oyavas PF 06439535 PF-06439535 PF06439535 Bevacizumab-aveg Bevacizumab-byva Bevacizumab-nwgd Jobevne IBI 305 IBI-305 Lék: Cisplatin Given IV Ostatní jména: CDDP Cis-diamindichloridoplatina Cismaplat Cisplatina Neoplatin Platinol Abiplatina Blastolem Briplatina Cis-diamin-dichloroplatina Cis-diamindichloroplatina (II) Cis-diamindichloroplatina Cis-dichlorammin platina (II) Cis-platinový diamindichlorid Cis-platina Cis-platina II Cis-platina II diamindichlorid Cisplatyl Citoplatino Citosin Cysplatyna DDP Lederplatina Metaplatina Peyronův chlorid Peyronova sůl Placis Plastistil Platamin Platiblastin Platiblastin-S Platinex Platinol-AQ Platinol-AQ VHA Plus Platinoxan Platina Diaminodichlorid platiny Platiran Platistin Platosin Lék: Docetaxel Given IV Ostatní jména: Taxotere Docecad RP56976 Injekční koncentrát Taxotere RP 56976 RP-56976
Aktivní komparátor: Arm IIA (docetaxel, carboplatin) Patients receive docetaxel IV over 1 hour and carboplatin IV over 30 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.	Lék: Carboplatin Given IV Ostatní jména: Blastocarb Carboplat Carboplatin Hexal Carboplatino Karboplatina Karbosin Carbosol Carbotec CBDCA Displata Ercar JM-8 Nealorin Novoplatina Paraplatin Paraplatin AQ Paraplatina Platinwas Ribocarbo JM8 Jiný: Laboratory Biomarker Analysis Correlative studies Lék: Docetaxel Given IV Ostatní jména: Taxotere Docecad RP56976 Injekční koncentrát Taxotere RP 56976 RP-56976
Experimentální: Arm IIB (docetaxel, carboplatin, bevacizumab) Patients receive bevacizumab as in Arm IB and docetaxel and carboplatin as in Arm IIA.	Lék: Carboplatin Given IV Ostatní jména: Blastocarb Carboplat Carboplatin Hexal Carboplatino Karboplatina Karbosin Carbosol Carbotec CBDCA Displata Ercar JM-8 Nealorin Novoplatina Paraplatin Paraplatin AQ Paraplatina Platinwas Ribocarbo JM8 Jiný: Laboratory Biomarker Analysis Correlative studies Biologický: Bevacizumab Given IV Ostatní jména: Avastin ABP 215 Anti-VEGF Anti-VEGF humanizovaná monoklonální protilátka Monoklonální protilátka proti VEGF SIBP04 Anti-VEGF rhuMAb Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Imunoglobulin G1 (lidský-myší monoklonální rhuMab-VEGF gama-řetězcový anti-lidský vaskulární endoteliální růstový faktor), disulfid s lidským-myším monoklonálním lehkým řetězcem rhuMab-VEGF, dimer Mvasi MYL-1402O Rekombinantní humanizovaná anti-VEGF monoklonální protilátka rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev Avegra QL1101 IBI305 Byvasda Bevacizumab Biosimilar QL1101 BAT1706 BAT 1706 BAT-1706 BAT1706 Biosimilar Bevacizumab Biosimilar BAT1706 Bevacizumab-adcd CT-P16 Vegzelma Alymsys ABP-215 ABP215 Aybintio Bevacizumab-aybi Bevacizumab-ekvi Bevacizumab-maly Bevacizumab-onbe ČT P16 CTP16 Ekvidacentní Onbevzi Avzivi Bevacizumab Biosimilar MB02 Bevacizumab-tnjn FKB 238 FKB-238 FKB238 MB 02 MB-02 MB02 Oyavas PF 06439535 PF-06439535 PF06439535 Bevacizumab-aveg Bevacizumab-byva Bevacizumab-nwgd Jobevne IBI 305 IBI-305 Lék: Docetaxel Given IV Ostatní jména: Taxotere Docecad RP56976 Injekční koncentrát Taxotere RP 56976 RP-56976
Aktivní komparátor: Arm IIIA (cisplatin, fluorouracil) Patients receive cisplatin IV over 1-2 hours on day 1 and fluorouracil IV continuously on days 1-4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.	Jiný: Laboratory Biomarker Analysis Correlative studies Lék: Cisplatin Given IV Ostatní jména: CDDP Cis-diamindichloridoplatina Cismaplat Cisplatina Neoplatin Platinol Abiplatina Blastolem Briplatina Cis-diamin-dichloroplatina Cis-diamindichloroplatina (II) Cis-diamindichloroplatina Cis-dichlorammin platina (II) Cis-platinový diamindichlorid Cis-platina Cis-platina II Cis-platina II diamindichlorid Cisplatyl Citoplatino Citosin Cysplatyna DDP Lederplatina Metaplatina Peyronův chlorid Peyronova sůl Placis Plastistil Platamin Platiblastin Platiblastin-S Platinex Platinol-AQ Platinol-AQ VHA Plus Platinoxan Platina Diaminodichlorid platiny Platiran Platistin Platosin Lék: Fluorouracil Given IV Ostatní jména: 5-Fluracil Fluracil 5 fluorouracil 5 Fluorouracilum 5 FU 5-Fluor-2,4(lH,3H)-pyrimidindion 5-Fluoruracil 5-Fu 5FU AccuSite Carac Fluoro uracil Fluuracil Flurablastin Fluracedyl Fluril Fluroblastin Ribofluor Ro 2-9757 Ro-2-9757
Experimentální: Arm IIIB (cisplatin, fluorouracil, bevacizumab) Patients receive bevacizumab as in Arm IB and cisplatin and fluorouracil as in Arm IIIA.	Jiný: Laboratory Biomarker Analysis Correlative studies Biologický: Bevacizumab Given IV Ostatní jména: Avastin ABP 215 Anti-VEGF Anti-VEGF humanizovaná monoklonální protilátka Monoklonální protilátka proti VEGF SIBP04 Anti-VEGF rhuMAb Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Imunoglobulin G1 (lidský-myší monoklonální rhuMab-VEGF gama-řetězcový anti-lidský vaskulární endoteliální růstový faktor), disulfid s lidským-myším monoklonálním lehkým řetězcem rhuMab-VEGF, dimer Mvasi MYL-1402O Rekombinantní humanizovaná anti-VEGF monoklonální protilátka rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev Avegra QL1101 IBI305 Byvasda Bevacizumab Biosimilar QL1101 BAT1706 BAT 1706 BAT-1706 BAT1706 Biosimilar Bevacizumab Biosimilar BAT1706 Bevacizumab-adcd CT-P16 Vegzelma Alymsys ABP-215 ABP215 Aybintio Bevacizumab-aybi Bevacizumab-ekvi Bevacizumab-maly Bevacizumab-onbe ČT P16 CTP16 Ekvidacentní Onbevzi Avzivi Bevacizumab Biosimilar MB02 Bevacizumab-tnjn FKB 238 FKB-238 FKB238 MB 02 MB-02 MB02 Oyavas PF 06439535 PF-06439535 PF06439535 Bevacizumab-aveg Bevacizumab-byva Bevacizumab-nwgd Jobevne IBI 305 IBI-305 Lék: Cisplatin Given IV Ostatní jména: CDDP Cis-diamindichloridoplatina Cismaplat Cisplatina Neoplatin Platinol Abiplatina Blastolem Briplatina Cis-diamin-dichloroplatina Cis-diamindichloroplatina (II) Cis-diamindichloroplatina Cis-dichlorammin platina (II) Cis-platinový diamindichlorid Cis-platina Cis-platina II Cis-platina II diamindichlorid Cisplatyl Citoplatino Citosin Cysplatyna DDP Lederplatina Metaplatina Peyronův chlorid Peyronova sůl Placis Plastistil Platamin Platiblastin Platiblastin-S Platinex Platinol-AQ Platinol-AQ VHA Plus Platinoxan Platina Diaminodichlorid platiny Platiran Platistin Platosin Lék: Fluorouracil Given IV Ostatní jména: 5-Fluracil Fluracil 5 fluorouracil 5 Fluorouracilum 5 FU 5-Fluor-2,4(lH,3H)-pyrimidindion 5-Fluoruracil 5-Fu 5FU AccuSite Carac Fluoro uracil Fluuracil Flurablastin Fluracedyl Fluril Fluroblastin Ribofluor Ro 2-9757 Ro-2-9757
Aktivní komparátor: Arm IVA (carboplatin, fluorouracil) Patients receive carboplatin IV over 30 minutes on day 1 and fluorouracil IV continuously on days 1-4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.	Lék: Carboplatin Given IV Ostatní jména: Blastocarb Carboplat Carboplatin Hexal Carboplatino Karboplatina Karbosin Carbosol Carbotec CBDCA Displata Ercar JM-8 Nealorin Novoplatina Paraplatin Paraplatin AQ Paraplatina Platinwas Ribocarbo JM8 Jiný: Laboratory Biomarker Analysis Correlative studies Lék: Fluorouracil Given IV Ostatní jména: 5-Fluracil Fluracil 5 fluorouracil 5 Fluorouracilum 5 FU 5-Fluor-2,4(lH,3H)-pyrimidindion 5-Fluoruracil 5-Fu 5FU AccuSite Carac Fluoro uracil Fluuracil Flurablastin Fluracedyl Fluril Fluroblastin Ribofluor Ro 2-9757 Ro-2-9757
Experimentální: Arm IVB (carboplatin, fluorouracil, bevacizumab) Patients receive bevacizumab as in Arm IB and carboplatin and fluorouracil as in Arm IVA.	Lék: Carboplatin Given IV Ostatní jména: Blastocarb Carboplat Carboplatin Hexal Carboplatino Karboplatina Karbosin Carbosol Carbotec CBDCA Displata Ercar JM-8 Nealorin Novoplatina Paraplatin Paraplatin AQ Paraplatina Platinwas Ribocarbo JM8 Jiný: Laboratory Biomarker Analysis Correlative studies Biologický: Bevacizumab Given IV Ostatní jména: Avastin ABP 215 Anti-VEGF Anti-VEGF humanizovaná monoklonální protilátka Monoklonální protilátka proti VEGF SIBP04 Anti-VEGF rhuMAb Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Imunoglobulin G1 (lidský-myší monoklonální rhuMab-VEGF gama-řetězcový anti-lidský vaskulární endoteliální růstový faktor), disulfid s lidským-myším monoklonálním lehkým řetězcem rhuMab-VEGF, dimer Mvasi MYL-1402O Rekombinantní humanizovaná anti-VEGF monoklonální protilátka rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev Avegra QL1101 IBI305 Byvasda Bevacizumab Biosimilar QL1101 BAT1706 BAT 1706 BAT-1706 BAT1706 Biosimilar Bevacizumab Biosimilar BAT1706 Bevacizumab-adcd CT-P16 Vegzelma Alymsys ABP-215 ABP215 Aybintio Bevacizumab-aybi Bevacizumab-ekvi Bevacizumab-maly Bevacizumab-onbe ČT P16 CTP16 Ekvidacentní Onbevzi Avzivi Bevacizumab Biosimilar MB02 Bevacizumab-tnjn FKB 238 FKB-238 FKB238 MB 02 MB-02 MB02 Oyavas PF 06439535 PF-06439535 PF06439535 Bevacizumab-aveg Bevacizumab-byva Bevacizumab-nwgd Jobevne IBI 305 IBI-305 Lék: Fluorouracil Given IV Ostatní jména: 5-Fluracil Fluracil 5 fluorouracil 5 Fluorouracilum 5 FU 5-Fluor-2,4(lH,3H)-pyrimidindion 5-Fluoruracil 5-Fu 5FU AccuSite Carac Fluoro uracil Fluuracil Flurablastin Fluracedyl Fluril Fluroblastin Ribofluor Ro 2-9757 Ro-2-9757

Co je měření studie?

Primární výstupní opatření

Měření výsledku	Popis opatření	Časové okno
Overall Survival (OS) Časové okno: assessed every 3 months within 2 years from study entry, then every 6 months up to 5 years from study entry	Overall survival (OS) was defined as time from randomization to death from any course. Patients who were alive were censored at the last contact date. Median OS was estimated using the Kaplan-Meier method.	assessed every 3 months within 2 years from study entry, then every 6 months up to 5 years from study entry

Sekundární výstupní opatření

Měření výsledku	Popis opatření	Časové okno
Progression-free Survival (PFS) Časové okno: on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks	Progression was defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions. Progression-free survival (PFS) was defined as the time from randomization to date of disease progression or death from any cause, whichever occurred first. Patients who were still alive and progression free were censored at last disease assessment date. Median PFS was estimated using Kaplan-Meier method.	on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks
Overall Response Rate Časové okno: on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks	Overall response rate is defined as number of patients with complete response (CR) or partial response (PR) divided by all patients. Responses are evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST) guideline. CR is defined as disappearance of all target and non-target lesions. PR is defined as disappearance of target lesions or at least a 30% decrease in the sum of the diameters of target lesions (taking as reference the baseline sum diameters), and persistence of one or more non-target lesion(s).	on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks

Další výstupní opatření

Měření výsledku	Popis opatření	Časové okno
To Collect Blood Samples Before and After Therapy for Future Correlative Studies Časové okno: Before and after therapy	These were blood and tissue samples collections and have no data to report.	Before and after therapy
To Collect Tumor Tissue Samples Available at Baseline From Prior Diagnostic Procedures for Future Correlative Studies Časové okno: Baseline	These were blood and tissue samples collections and have no data to report.	Baseline

Spolupracovníci a vyšetřovatelé

Zde najdete lidi a organizace zapojené do této studie.

Sponzor

National Cancer Institute (NCI)

Vyšetřovatelé

Vrchní vyšetřovatel: Athanassios (Ethan) Argiris, ECOG-ACRIN Cancer Research Group

Publikace a užitečné odkazy

Osoba odpovědná za zadávání informací o studiu tyto publikace poskytuje dobrovolně. Mohou se týkat čehokoli, co souvisí se studiem.

Obecné publikace

Argiris A, Li S, Savvides P, Ohr JP, Gilbert J, Levine MA, Chakravarti A, Haigentz M Jr, Saba NF, Ikpeazu CV, Schneider CJ, Pinto HA, Forastiere AA, Burtness B. Phase III Randomized Trial of Chemotherapy With or Without Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer. J Clin Oncol. 2019 Dec 1;37(34):3266-3274. doi: 10.1200/JCO.19.00555. Epub 2019 Oct 16.

Termíny studijních záznamů

Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.

Hlavní termíny studia

Začátek studia (Aktuální)

8. srpna 2008

Primární dokončení (Aktuální)

5. června 2018

Dokončení studie (Odhadovaný)

20. února 2027

Termíny zápisu do studia

První předloženo

28. prosince 2007

První předloženo, které splnilo kritéria kontroly kvality

28. prosince 2007

První zveřejněno (Odhadovaný)

9. ledna 2008

Aktualizace studijních záznamů

Poslední zveřejněná aktualizace (Aktuální)

22. října 2026

Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality

21. října 2026

Naposledy ověřeno

1. srpna 2026

Více informací

Termíny související s touto studií

Další relevantní podmínky MeSH

Další identifikační čísla studie

NCI-2009-00507
U10CA180820 (Grant/smlouva NIH USA)
U10CA021115 (Grant/smlouva NIH USA)
NCI-2009-00507 (Identifikátor registru: CTRP (Clinical Trial Reporting Program))
E1305 (Jiný identifikátor: CTEP)
CDR0000582533
E1305
E1305 (Jiný identifikátor: ECOG-ACRIN Cancer Research Group)

Tyto informace byly beze změn načteny přímo z webu clinicaltrials.gov. Máte-li jakékoli požadavky na změnu, odstranění nebo aktualizaci podrobností studie, kontaktujte prosím register@clinicaltrials.gov. Jakmile bude změna implementována na clinicaltrials.gov, bude automaticky aktualizována i na našem webu .

Chemoterapie s bevacizumabem nebo bez něj při léčbě pacientů s recidivujícím nebo metastatickým spinocelulárním karcinomem hlavy a krku

Randomizovaná studie fáze III chemoterapie s bevacizumabem nebo bez něj u pacientů s recidivujícím nebo metastatickým karcinomem hlavy a krku

Přehled studie

Postavení

Podmínky

Intervence / Léčba

Detailní popis

Typ studie

Zápis (Aktuální)

Fáze

Kontakty a umístění

Studijní místa

Kritéria účasti

Kritéria způsobilosti

Věk způsobilý ke studiu

Přijímá zdravé dobrovolníky

Pohlaví způsobilá ke studiu

Popis

Studijní plán

Jak je studie koncipována?

Detaily designu

Počet zbraní

Zbraně a zásahy

Skupina účastníků / Arm

Intervence / Léčba

Co je měření studie?

Primární výstupní opatření

Měření výsledku

Popis opatření

Časové okno

Sekundární výstupní opatření

Měření výsledku

Popis opatření

Časové okno

Další výstupní opatření

Měření výsledku

Popis opatření

Časové okno

Spolupracovníci a vyšetřovatelé

Sponzor

Vyšetřovatelé

Publikace a užitečné odkazy

Obecné publikace

Termíny studijních záznamů

Hlavní termíny studia

Začátek studia (Aktuální)

Primární dokončení (Aktuální)

Dokončení studie (Odhadovaný)

Termíny zápisu do studia

První předloženo

První předloženo, které splnilo kritéria kontroly kvality

První zveřejněno (Odhadovaný)

Aktualizace studijních záznamů

Poslední zveřejněná aktualizace (Aktuální)

Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality

Naposledy ověřeno

Více informací

Termíny související s touto studií

Další relevantní podmínky MeSH

Další identifikační čísla studie