Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
April 3, 2024 updated by: National Cancer Institute (NCI)
A Phase III Randomized Trial of Chemotherapy With or Without Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer
This randomized phase III trial studies chemotherapy to see how well it works with or without bevacizumab in treating patients with head and neck squamous cell carcinoma that has come back (recurrent) or that has spread to other parts of the body (metastatic).
Drugs used in chemotherapy, such as docetaxel, cisplatin, carboplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread.
Bevacizumab may also make tumor cells more sensitive to chemotherapy and stop the growth of head and neck cancer by blocking blood flow to the tumor.
It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab in treating patients with head and neck squamous cell carcinoma.
Study Overview
Status
Active, not recruiting
Conditions
- Recurrent Hypopharyngeal Squamous Cell Carcinoma
- Recurrent Laryngeal Squamous Cell Carcinoma
- Recurrent Oropharyngeal Squamous Cell Carcinoma
- Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7
- Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7
- Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7
- Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7
- Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7
- Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7
- Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7
- Salivary Gland Squamous Cell Carcinoma
- Recurrent Lip and Oral Cavity Squamous Cell Carcinoma
- Recurrent Sinonasal Squamous Cell Carcinoma
- Stage IVA Oral Cavity Cancer AJCC v6 and v7
- Stage IVB Oral Cavity Cancer AJCC v6 and v7
- Stage IVC Oral Cavity Cancer AJCC v6 and v7
- Recurrent Laryngeal Verrucous Carcinoma
- Recurrent Oral Cavity Verrucous Carcinoma
- Recurrent Salivary Gland Carcinoma
- Stage IVA Laryngeal Verrucous Carcinoma AJCC v7
- Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
- Stage IVA Major Salivary Gland Cancer AJCC v7
- Stage IVB Laryngeal Verrucous Carcinoma AJCC v7
- Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
- Stage IVB Major Salivary Gland Cancer AJCC v7
- Stage IVC Laryngeal Verrucous Carcinoma AJCC v7
- Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
- Stage IVC Major Salivary Gland Cancer AJCC v7
- Tongue Carcinoma
- Stage IVA Sinonasal Squamous Cell Carcinoma AJCC v7
- Stage IVB Sinonasal Squamous Cell Carcinoma AJCC v7
- Stage IVC Sinonasal Squamous Cell Carcinoma AJCC v7
- Neck Squamous Cell Carcinoma of Unknown Primary
- Recurrent Neck Squamous Cell Carcinoma of Unknown Primary
- Stage IV Major Salivary Gland Cancer AJCC v7
Detailed Description
PRIMARY OBJECTIVES:
I. To compare the overall survival of patients with recurrent or metastatic head and neck cancer treated with standard platinum-based chemotherapy with or without bevacizumab.
SECONDARY OBJECTIVES:
I. To assess toxicities with the addition of bevacizumab to each platinum-doublet (cisplatin/docetaxel, carboplatin/docetaxel, cisplatin/fluorouracil [5-FU], carboplatin/5-FU).
II. To compare the objective response rates and the progression-free survival achieved with the above therapies.
III. To collect blood samples before and after therapy for future correlative studies.
IV. To collect tumor tissue samples available at baseline from prior diagnostic procedures for future correlative studies.
OUTLINE: After the physician decides which chemotherapy doublet to use, patients are randomized to 1 of 2 treatment arms for that chemotherapy combination.
ARM IA: Patients receive chemotherapy comprising docetaxel intravenously (IV) over 1 hour and cisplatin IV over 1-2 hours on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM IB: Patients receive bevacizumab IV over 30-90 minutes on day 1 and docetaxel and cisplatin as in Arm IA.
ARM IIA: Patients receive docetaxel IV over 1 hour and carboplatin IV over 30 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM IIB: Patients receive bevacizumab as in arm IB and docetaxel and carboplatin as in Arm IIA.
ARM IIIA: Patients receive cisplatin IV over 1-2 hours on day 1 and fluorouracil IV continuously on days 1-4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM IIIB: Patients receive bevacizumab as in Arm IB and cisplatin and fluorouracil as in Arm IIIA.
ARM IVA: Patients receive carboplatin IV over 30 minutes on day 1 and fluorouracil IV continuously on days 1-4. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM IVB: Patients receive bevacizumab as in Arm IB and carboplatin and fluorouracil as in Arm IVA.
After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.
Study Type
Interventional
Enrollment (Actual)
403
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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San Juan, Puerto Rico, 00936
- San Juan City Hospital
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Pretoria, South Africa, 0002
- University Of Pretoria
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Alabama
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Mobile, Alabama, United States, 36688
- University of South Alabama Mitchell Cancer Institute
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Mobile, Alabama, United States, 36608
- Providence Hospital
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Alaska
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Fairbanks, Alaska, United States, 99701
- Fairbanks Memorial Hospital
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Arkansas
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Fort Smith, Arkansas, United States, 72903
- Mercy Hospital Fort Smith
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Jonesboro, Arkansas, United States, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, United States, 72205
- University of Arkansas for Medical Sciences
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Little Rock, Arkansas, United States, 72205
- John L McClellan Memorial Veterans Hospital
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California
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Anaheim, California, United States, 92806
- Kaiser Permanente-Anaheim
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Baldwin Park, California, United States, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, United States, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, United States, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, United States, 94010
- Mills-Peninsula Medical Center
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Castro Valley, California, United States, 94546
- Eden Hospital Medical Center
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Castro Valley, California, United States, 94546
- East Bay Radiation Oncology Center
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Castro Valley, California, United States, 94546
- Valley Medical Oncology Consultants-Castro Valley
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Dublin, California, United States, 94568
- Epic Care-Dublin
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Emeryville, California, United States, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, United States, 94608
- Epic Care Partners in Cancer Care
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Fontana, California, United States, 92335
- Kaiser Permanente-Fontana
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Fremont, California, United States, 94538
- Valley Medical Oncology Consultants-Fremont
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Harbor City, California, United States, 90710
- Kaiser Permanente - Harbor City
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Irvine, California, United States, 92618
- Kaiser Permanente-Irvine
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La Jolla, California, United States, 92093
- UC San Diego Moores Cancer Center
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Los Angeles, California, United States, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, United States, 90034
- Kaiser Permanente West Los Angeles
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Martinez, California, United States, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, United States, 95355
- Memorial Medical Center
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Mountain View, California, United States, 94040
- El Camino Hospital
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Novato, California, United States, 94945
- Sutter Cancer Research Consortium
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Oakland, California, United States, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, United States, 94609
- Hematology and Oncology Associates-Oakland
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Oakland, California, United States, 94602
- Highland General Hospital
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Oakland, California, United States, 94609
- Tom K Lee Inc
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Oakland, California, United States, 94609
- Bay Area Tumor Institute
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Palo Alto, California, United States, 94304
- VA Palo Alto Health Care System
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Palo Alto, California, United States, 94304
- Stanford Cancer Institute Palo Alto
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Panorama City, California, United States, 91402
- Kaiser Permanente - Panorama City
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Pleasanton, California, United States, 94588
- Valley Care Health System - Pleasanton
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Pleasanton, California, United States, 94588
- Valley Medical Oncology Consultants
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Riverside, California, United States, 92505
- Kaiser Permanente-Riverside
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Saint Helena, California, United States, 94574
- Saint Helena Hospital
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San Diego, California, United States, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, United States, 92108
- Kaiser Permanente-San Diego Mission
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San Diego, California, United States, 92161
- San Diego VA Medical Center
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San Francisco, California, United States, 94115
- California Pacific Medical Center-Pacific Campus
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San Marcos, California, United States, 92078
- Kaiser Permanente-San Marcos
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San Pablo, California, United States, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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Santa Rosa, California, United States, 95403
- Sutter Pacific Medical Foundation
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Vallejo, California, United States, 94589
- Sutter Solano Medical Center/Cancer Center
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Woodland Hills, California, United States, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, United States, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, United States, 80012
- The Medical Center of Aurora
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Boulder, Colorado, United States, 80301
- Boulder Community Hospital
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Boulder, Colorado, United States, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, United States, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, United States, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, United States, 80210
- Porter Adventist Hospital
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Denver, Colorado, United States, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, United States, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, United States, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, United States, 80220
- Rose Medical Center
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Denver, Colorado, United States, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, United States, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, United States, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, United States, 80222
- Western States Cancer Research NCORP
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Durango, Colorado, United States, 81301
- Mercy Medical Center
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Durango, Colorado, United States, 81301
- Southwest Oncology PC
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Englewood, Colorado, United States, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, United States, 80113
- Swedish Medical Center
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Fort Collins, Colorado, United States, 80524
- Poudre Valley Hospital
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Golden, Colorado, United States, 80401
- Mountain Blue Cancer Care Center
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Grand Junction, Colorado, United States, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, United States, 80631
- North Colorado Medical Center
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Greenwood Village, Colorado, United States, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lafayette, Colorado, United States, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, United States, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, United States, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, United States, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, United States, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, United States, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, United States, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, United States, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, United States, 80501
- Longmont United Hospital
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Longmont, Colorado, United States, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, United States, 80539
- McKee Medical Center
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Parker, Colorado, United States, 80138
- Parker Adventist Hospital
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Parker, Colorado, United States, 80138
- Rocky Mountain Cancer Centers-Parker
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Pueblo, Colorado, United States, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, United States, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, United States, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, United States, 80229
- North Suburban Medical Center
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Wheat Ridge, Colorado, United States, 80033
- SCL Health Lutheran Medical Center
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Connecticut
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Farmington, Connecticut, United States, 06030
- University of Connecticut
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Hartford, Connecticut, United States, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Britain, Connecticut, United States, 06050
- The Hospital of Central Connecticut
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New Haven, Connecticut, United States, 06520
- Yale University
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Norwich, Connecticut, United States, 06360
- Eastern Connecticut Hematology and Oncology Associates
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Delaware
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Dover, Delaware, United States, 19901
- Bayhealth Hospital Kent Campus
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Lewes, Delaware, United States, 19958
- Beebe Medical Center
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Newark, Delaware, United States, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, United States, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, United States, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, United States, 19718
- Christiana Care Health System-Christiana Hospital
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Newark, Delaware, United States, 19713
- Christiana Gynecologic Oncology LLC
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Rehoboth Beach, Delaware, United States, 19971
- Beebe Health Campus
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Seaford, Delaware, United States, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, United States, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington, District of Columbia, United States, 20007
- MedStar Georgetown University Hospital
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Washington, District of Columbia, United States, 20037
- George Washington University Medical Center
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Florida
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Boca Raton, Florida, United States, 33486
- Boca Raton Regional Hospital
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Fort Lauderdale, Florida, United States, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, United States, 33308
- Holy Cross Hospital
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Gainesville, Florida, United States, 32610
- University of Florida Health Science Center - Gainesville
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Gainesville, Florida, United States, 32605
- Florida Cancer Specialists-Gainesville Cancer Center
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Hollywood, Florida, United States, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
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Jacksonville, Florida, United States, 32207
- Baptist MD Anderson Cancer Center
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Jupiter, Florida, United States, 33458
- Jupiter Medical Center
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Miami, Florida, United States, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami Beach, Florida, United States, 33140
- Mount Sinai Medical Center
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Pembroke Pines, Florida, United States, 33028
- Memorial Hospital West
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Pensacola, Florida, United States, 32504
- Sacred Heart Hospital
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Titusville, Florida, United States, 32796
- Space Coast Cancer Centers-Titusville
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Weston, Florida, United States, 33331
- Cleveland Clinic-Weston
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Georgia
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Atlanta, Georgia, United States, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, United States, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, United States, 30342
- Emory Saint Joseph's Hospital
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Atlanta, Georgia, United States, 30309
- Piedmont Hospital
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Atlanta, Georgia, United States, 30342
- Northside Hospital
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Atlanta, Georgia, United States, 30342
- Atlanta Regional CCOP
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Austell, Georgia, United States, 30106
- WellStar Cobb Hospital
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Columbus, Georgia, United States, 31904
- John B Amos Cancer Center
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Decatur, Georgia, United States, 30033
- Dekalb Medical Center
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Decatur, Georgia, United States, 30033
- Atlanta VA Medical Center
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Fayetteville, Georgia, United States, 30214
- Piedmont Fayette Hospital
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Gainesville, Georgia, United States, 30501
- Northeast Georgia Medical Center-Gainesville
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Lawrenceville, Georgia, United States, 30046
- Northside Hospital - Gwinnett
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Marietta, Georgia, United States, 30060
- Wellstar Kennestone Hospital
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Riverdale, Georgia, United States, 30274
- Southern Regional Medical Center
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Rome, Georgia, United States, 30165
- Harbin Clinic Medical Oncology and Clinical Research
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Savannah, Georgia, United States, 31404
- Memorial Health University Medical Center
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Savannah, Georgia, United States, 31404
- Summit Cancer Care-Memorial
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Savannah, Georgia, United States, 31404
- Low Country Cancer Care
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Hawaii
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'Aiea, Hawaii, United States, 96701
- Pali Momi Medical Center
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Honolulu, Hawaii, United States, 96813
- Queen's Medical Center
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Honolulu, Hawaii, United States, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, United States, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, United States, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, United States, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, United States, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, United States, 96826
- Kapiolani Medical Center for Women and Children
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Wailuku, Hawaii, United States, 96793
- Maui Memorial Medical Center
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Wailuku, Hawaii, United States, 96793
- Pacific Cancer Institute of Maui
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Idaho
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Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, United States, 83712
- Saint Luke's Cancer Institute - Boise
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Fruitland, Idaho, United States, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, United States, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, United States, 83686
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, United States, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Twin Falls, Idaho, United States, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, United States, 60504
- Rush - Copley Medical Center
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Berwyn, Illinois, United States, 60402
- Mac Neal Hospital
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Bloomington, Illinois, United States, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, United States, 61701
- Saint Joseph Medical Center
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Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
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Canton, Illinois, United States, 61520
- Graham Hospital Association
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Carbondale, Illinois, United States, 62902
- Memorial Hospital of Carbondale
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Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
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Carthage, Illinois, United States, 62321
- Memorial Hospital
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Centralia, Illinois, United States, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, United States, 60611
- Northwestern University
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Chicago, Illinois, United States, 60612
- University of Illinois
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Chicago, Illinois, United States, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, United States, 60657
- UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
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Chicago, Illinois, United States, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, United States, 60611
- Hematology and Oncology Associates
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Chicago, Illinois, United States, 60631
- Presence Resurrection Medical Center
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Chicago, Illinois, United States, 60640
- Weiss Memorial Hospital
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Danville, Illinois, United States, 61832
- Carle at The Riverfront
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Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, United States, 62526
- Cancer Care Specialists of Illinois - Decatur
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Decatur, Illinois, United States, 62526
- Heartland Cancer Research NCORP
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Downers Grove, Illinois, United States, 60515
- Advocate Good Samaritan Hospital
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Effingham, Illinois, United States, 62401
- Crossroads Cancer Center
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Effingham, Illinois, United States, 62401
- Carle Physician Group-Effingham
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Elmhurst, Illinois, United States, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
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Eureka, Illinois, United States, 61530
- Eureka Hospital
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Evanston, Illinois, United States, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, United States, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, United States, 61401
- Illinois CancerCare-Galesburg
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Galesburg, Illinois, United States, 61401
- Galesburg Cottage Hospital
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Glenview, Illinois, United States, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Harvey, Illinois, United States, 60426
- Ingalls Memorial Hospital
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Havana, Illinois, United States, 62644
- Mason District Hospital
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Havana, Illinois, United States, 62644
- Illinois CancerCare-Havana
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Highland Park, Illinois, United States, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Highland Park, Illinois, United States, 60035
- Hematology Oncology Associates of Illinois-Highland Park
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Hinsdale, Illinois, United States, 60521
- Hinsdale Hematology Oncology Associates Incorporated
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Hopedale, Illinois, United States, 61747
- Hopedale Medical Complex - Hospital
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Joliet, Illinois, United States, 60435
- Duly Health and Care Joliet
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Joliet, Illinois, United States, 60432
- Midwest Center for Hematology Oncology
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Kankakee, Illinois, United States, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
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La Grange, Illinois, United States, 60525
- AMITA Health Adventist Medical Center
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Libertyville, Illinois, United States, 60048
- AMG Libertyville - Oncology
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Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
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Macomb, Illinois, United States, 61455
- Mcdonough District Hospital
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Mattoon, Illinois, United States, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, United States, 60153
- Loyola University Medical Center
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Moline, Illinois, United States, 61265
- Garneau, Stewart C MD (UIA Investigator)
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Moline, Illinois, United States, 61265
- Porubcin, Michael MD (UIA Investigator)
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Moline, Illinois, United States, 61265
- Spector, David MD (UIA Investigator)
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Moline, Illinois, United States, 61265
- Trinity Medical Center
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Monmouth, Illinois, United States, 61462
- Illinois CancerCare-Monmouth
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Monmouth, Illinois, United States, 61462
- Holy Family Medical Center
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Mount Vernon, Illinois, United States, 62864
- Good Samaritan Regional Health Center
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Niles, Illinois, United States, 60714
- Illinois Cancer Specialists-Niles
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Normal, Illinois, United States, 61761
- Carle Cancer Institute Normal
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Normal, Illinois, United States, 61761
- Bromenn Regional Medical Center
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Normal, Illinois, United States, 61761
- Illinois CancerCare-Community Cancer Center
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Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
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Ottawa, Illinois, United States, 61350
- Radiation Oncology of Northern Illinois
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Ottawa, Illinois, United States, 61350
- Ottawa Regional Hospital and Healthcare Center
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Pekin, Illinois, United States, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, United States, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
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Pekin, Illinois, United States, 61554
- Pekin Hospital
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Peoria, Illinois, United States, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, United States, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, United States, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peoria, Illinois, United States, 61614
- Proctor Hospital
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Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, United States, 61354
- Valley Radiation Oncology
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Peru, Illinois, United States, 61354
- Illinois Valley Hospital
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Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
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Princeton, Illinois, United States, 61356
- Perry Memorial Hospital
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River Forest, Illinois, United States, 60305
- West Suburban Medical Center
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Rockford, Illinois, United States, 61114
- SwedishAmerican Regional Cancer Center/ACT
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Rockford, Illinois, United States, 61104
- Swedish American Hospital
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Skokie, Illinois, United States, 60076
- Hematology Oncology Associates of Illinois - Skokie
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Spring Valley, Illinois, United States, 61362
- Saint Margaret's Hospital
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Spring Valley, Illinois, United States, 61362
- Illinois CancerCare-Spring Valley
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Springfield, Illinois, United States, 62781
- Memorial Medical Center
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Springfield, Illinois, United States, 62702
- Central Illinois Hematology Oncology Center
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Urbana, Illinois, United States, 61801
- Carle Cancer Center
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Urbana, Illinois, United States, 61801
- The Carle Foundation Hospital
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Yorkville, Illinois, United States, 60560
- Rush-Copley Healthcare Center
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Indiana
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Elkhart, Indiana, United States, 46515
- Elkhart General Hospital
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Elkhart, Indiana, United States, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, United States, 46514-2098
- Elkhart Clinic
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Fort Wayne, Indiana, United States, 46845
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
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Indianapolis, Indiana, United States, 46260
- Ascension Saint Vincent Indianapolis Hospital
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Indianapolis, Indiana, United States, 46202
- Sidney and Lois Eskenazi Hospital
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Kokomo, Indiana, United States, 46904
- Community Howard Regional Health
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La Porte, Indiana, United States, 46350
- IU Health La Porte Hospital
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Lafayette, Indiana, United States, 47904
- IU Health Arnett Cancer Care
-
Michigan City, Indiana, United States, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, United States, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, United States, 46545
- Memorial Regional Cancer Center Day Road
-
Mishawaka, Indiana, United States, 46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka, Indiana, United States, 46545
- Cancer Care Partners LLC
-
Mishawaka, Indiana, United States, 46545
- Saint Joseph Regional Medical Center-Mishawaka
-
Muncie, Indiana, United States, 47303
- IU Health Ball Memorial Hospital
-
Plymouth, Indiana, United States, 46563
- Michiana Hematology Oncology PC-Plymouth
-
South Bend, Indiana, United States, 46601
- Memorial Hospital of South Bend
-
South Bend, Indiana, United States, 46601
- Michiana Hematology Oncology PC-South Bend
-
South Bend, Indiana, United States, 46628
- Northern Indiana Cancer Research Consortium
-
South Bend, Indiana, United States, 46617
- South Bend Clinic
-
Westville, Indiana, United States, 46391
- Michiana Hematology Oncology PC-Westville
-
-
Iowa
-
Ames, Iowa, United States, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, United States, 50010
- McFarland Clinic - Ames
-
Bettendorf, Iowa, United States, 52722
- Constantinou, Costas L MD (UIA Investigator)
-
Bettendorf, Iowa, United States, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, United States, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, United States, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, United States, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, United States, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, United States, 51503
- Alegent Health Mercy Hospital
-
Des Moines, Iowa, United States, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, United States, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, United States, 50314
- Mission Cancer and Blood - Laurel
-
Des Moines, Iowa, United States, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, United States, 50309
- Iowa-Wide Oncology Research Coalition NCORP
-
Des Moines, Iowa, United States, 50307
- Mercy Capitol
-
Fort Dodge, Iowa, United States, 50501
- McFarland Clinic - Trinity Cancer Center
-
Iowa City, Iowa, United States, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Jefferson, Iowa, United States, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, United States, 50158
- McFarland Clinic - Marshalltown
-
Mason City, Iowa, United States, 50401
- Mercy Medical Center - North Iowa
-
Ottumwa, Iowa, United States, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, United States, 51101
- Siouxland Regional Cancer Center
-
Sioux City, Iowa, United States, 51102
- Mercy Medical Center-Sioux City
-
Sioux City, Iowa, United States, 51104
- Saint Luke's Regional Medical Center
-
West Des Moines, Iowa, United States, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, United States, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, United States, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, United States, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, United States, 66701
- Cancer Center of Kansas - Fort Scott
-
Independence, Kansas, United States, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, United States, 66112
- Providence Medical Center
-
Kingman, Kansas, United States, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, United States, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, United States, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, United States, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, United States, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, United States, 67114
- Cancer Center of Kansas - Newton
-
Overland Park, Kansas, United States, 66209
- Menorah Medical Center
-
Overland Park, Kansas, United States, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, United States, 67357
- Cancer Center of Kansas - Parsons
-
Prairie Village, Kansas, United States, 66208
- Kansas City NCI Community Oncology Research Program
-
Pratt, Kansas, United States, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, United States, 67401
- Cancer Center of Kansas - Salina
-
Shawnee Mission, Kansas, United States, 66204
- Advent Health - Shawnee Mission Medical Center
-
Wellington, Kansas, United States, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, United States, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, United States, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, United States, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, United States, 67208
- Associates In Womens Health
-
Wichita, Kansas, United States, 67214
- Wichita NCI Community Oncology Research Program
-
Wichita, Kansas, United States, 67214
- Wesley Medical Center
-
Winfield, Kansas, United States, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Ashland, Kentucky, United States, 41101
- Our Lady Bellefonte Hospital
-
Bardstown, Kentucky, United States, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, United States, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, United States, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, United States, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, United States, 40509
- Saint Joseph Hospital East
-
Louisville, Kentucky, United States, 40202
- Jewish Hospital
-
Louisville, Kentucky, United States, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, United States, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, United States, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, United States, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, United States, 70806
- Baton Rouge General Medical Center
-
Baton Rouge, Louisiana, United States, 70809
- Hematology/Oncology Clinic PLLC
-
Marrero, Louisiana, United States, 70072
- West Jefferson Medical Center
-
Metairie, Louisiana, United States, 70006
- Robert Veith MD LLC
-
Monroe, Louisiana, United States, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, United States, 70112
- Tulane University School of Medicine
-
New Orleans, Louisiana, United States, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, United States, 70112
- Louisiana State University Health Science Center
-
Shreveport, Louisiana, United States, 71103
- LSU Health Sciences Center at Shreveport
-
Shreveport, Louisiana, United States, 71105
- Highland Clinic
-
-
Maine
-
Augusta, Maine, United States, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, United States, 04401
- Eastern Maine Medical Center
-
-
Maryland
-
Baltimore, Maryland, United States, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, United States, 21204
- Greater Baltimore Medical Center
-
Elkton, Maryland, United States, 21921
- Christiana Care - Union Hospital
-
Frederick, Maryland, United States, 21701
- Frederick Memorial Hospital
-
-
Massachusetts
-
Attleboro, Massachusetts, United States, 02703
- Sturdy Memorial Hospital
-
Beverly, Massachusetts, United States, 01915
- Beverly Hospital
-
Boston, Massachusetts, United States, 02111
- Tufts Medical Center
-
Boston, Massachusetts, United States, 02118
- Boston Medical Center
-
Gloucester, Massachusetts, United States, 01930
- Addison Gilbert Hospital
-
Methuen, Massachusetts, United States, 01844
- Holy Family Hospital
-
Pittsfield, Massachusetts, United States, 01201
- Berkshire Medical Center - Cancer Center
-
Springfield, Massachusetts, United States, 01199
- Baystate Medical Center
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48109
- University of Michigan Comprehensive Cancer Center
-
Ann Arbor, Michigan, United States, 48106
- Saint Joseph Mercy Hospital
-
Ann Arbor, Michigan, United States, 48106
- Michigan Cancer Research Consortium NCORP
-
Battle Creek, Michigan, United States, 49017
- Bronson Battle Creek
-
Big Rapids, Michigan, United States, 49307
- Spectrum Health Big Rapids Hospital
-
Dearborn, Michigan, United States, 48124
- Beaumont Hospital - Dearborn
-
Detroit, Michigan, United States, 48236
- Ascension Saint John Hospital
-
Escanaba, Michigan, United States, 49829
- Green Bay Oncology - Escanaba
-
Farmington Hills, Michigan, United States, 48336
- Beaumont Hospital - Farmington Hills
-
Flint, Michigan, United States, 48532
- Genesys Regional Medical Center-West Flint Campus
-
Flint, Michigan, United States, 48503
- Hurley Medical Center
-
Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, United States, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, United States, 49503
- Cancer Research Consortium of West Michigan NCORP
-
Grand Rapids, Michigan, United States, 49503
- Trinity Health Grand Rapids Hospital
-
Iron Mountain, Michigan, United States, 49801
- Green Bay Oncology - Iron Mountain
-
Jackson, Michigan, United States, 49201
- Allegiance Health
-
Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, United States, 49048
- Borgess Medical Center
-
Lansing, Michigan, United States, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, United States, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Marquette, Michigan, United States, 49855
- UP Health System Marquette
-
Muskegon, Michigan, United States, 49442
- Mercy Health Partners-Hackley Campus
-
Muskegon, Michigan, United States, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, United States, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Pontiac, Michigan, United States, 48341
- Saint Joseph Mercy Oakland
-
Port Huron, Michigan, United States, 48060
- Lake Huron Medical Center
-
Reed City, Michigan, United States, 49677
- Corewell Health Reed City Hospital
-
Royal Oak, Michigan, United States, 48073
- William Beaumont Hospital-Royal Oak
-
Saginaw, Michigan, United States, 48601
- Ascension Saint Mary's Hospital
-
Saint Joseph, Michigan, United States, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, United States, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Traverse City, Michigan, United States, 49684
- Munson Medical Center
-
Troy, Michigan, United States, 48085
- William Beaumont Hospital - Troy
-
Warren, Michigan, United States, 48093
- Saint John Macomb-Oakland Hospital
-
Wyoming, Michigan, United States, 49519
- University of Michigan Health - West
-
-
Minnesota
-
Alexandria, Minnesota, United States, 56308
- Medini, Eitan MD (UIA Investigator)
-
Brainerd, Minnesota, United States, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, United States, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
-
Duluth, Minnesota, United States, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, United States, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, United States, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, United States, 55435
- Fairview Southdale Hospital
-
Fridley, Minnesota, United States, 55432
- Unity Hospital
-
Hutchinson, Minnesota, United States, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, United States, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, United States, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, United States, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, United States, 55454
- Health Partners Inc
-
New Ulm, Minnesota, United States, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, United States, 55422
- North Memorial Medical Health Center
-
Saint Cloud, Minnesota, United States, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Cloud, Minnesota, United States, 56303
- Saint Cloud Hospital
-
Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, United States, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, United States, 55101
- Regions Hospital
-
Saint Paul, Minnesota, United States, 55102
- United Hospital
-
Shakopee, Minnesota, United States, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, United States, 55082
- Lakeview Hospital
-
Waconia, Minnesota, United States, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, United States, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, United States, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Gulfport, Mississippi, United States, 39502
- Gulfport Memorial Hospital
-
Hattiesburg, Mississippi, United States, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, United States, 39404
- Forrest General Hospital / Cancer Center
-
Jackson, Mississippi, United States, 39216
- University of Mississippi Medical Center
-
Pascagoula, Mississippi, United States, 39581
- Singing River Hospital
-
-
Missouri
-
Bolivar, Missouri, United States, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, United States, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, United States, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, United States, 63703
- Southeast Cancer Center
-
Cape Girardeau, Missouri, United States, 63701
- Southeast Missouri Hospital
-
Columbia, Missouri, United States, 65201
- Veterans Administration
-
Columbia, Missouri, United States, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Independence, Missouri, United States, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, United States, 65109
- Capital Region Southwest Campus
-
Joplin, Missouri, United States, 64804
- Freeman Health System
-
Joplin, Missouri, United States, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, United States, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, United States, 64111
- Saint Luke'S Hospital of Kansas City
-
Kansas City, Missouri, United States, 64132
- Research Medical Center
-
Kansas City, Missouri, United States, 64108
- Truman Medical Centers
-
Kansas City, Missouri, United States, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, United States, 64114
- Saint Joseph Health Center
-
Lee's Summit, Missouri, United States, 64086
- Saint Luke's East - Lee's Summit
-
Liberty, Missouri, United States, 64068
- Liberty Radiation Oncology Center
-
Rolla, Missouri, United States, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, United States, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, United States, 64506
- Heartland Regional Medical Center
-
Saint Joseph, Missouri, United States, 64507
- Saint Joseph Oncology Inc
-
Saint Louis, Missouri, United States, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, United States, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, United States, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, United States, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Louis, Missouri, United States, 63104
- SSM Health Saint Louis University Hospital
-
Saint Louis, Missouri, United States, 63141
- Center for Cancer Care and Research
-
Saint Louis, Missouri, United States, 63141
- Comprehensive Cancer Care PC
-
Sainte Genevieve, Missouri, United States, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, United States, 65804
- Cancer Research for the Ozarks NCORP
-
Springfield, Missouri, United States, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, United States, 65804
- Mercy Hospital Springfield
-
Sullivan, Missouri, United States, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, United States, 63127
- BJC Outpatient Center at Sunset Hills
-
-
Montana
-
Billings, Montana, United States, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, United States, 59101
- Saint Vincent Healthcare
-
Billings, Montana, United States, 59102
- Montana Cancer Consortium NCORP
-
Billings, Montana, United States, 59101
- Northern Rockies Radiation Oncology Center
-
Billings, Montana, United States, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, United States, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, United States, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, United States, 59405
- Great Falls Clinic
-
Great Falls, Montana, United States, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Great Falls, Montana, United States, 59405
- Berdeaux, Donald MD (UIA Investigator)
-
Havre, Montana, United States, 59501
- Northern Montana Hospital
-
Helena, Montana, United States, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, United States, 59901
- Kalispell Regional Medical Center
-
Kalispell, Montana, United States, 59901
- Glacier Oncology PLLC
-
Kalispell, Montana, United States, 59901
- Kalispell Medical Oncology
-
Missoula, Montana, United States, 59804
- Community Medical Hospital
-
Missoula, Montana, United States, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, United States, 59804
- Guardian Oncology and Center for Wellness
-
Missoula, Montana, United States, 59802
- Montana Cancer Specialists
-
-
Nebraska
-
Grand Island, Nebraska, United States, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, United States, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, United States, 68845
- Heartland Hematology and Oncology
-
Lincoln, Nebraska, United States, 68506
- Nebraska Hematology and Oncology
-
Lincoln, Nebraska, United States, 68510
- Nebraska Cancer Research Center
-
Lincoln, Nebraska, United States, 68516
- Southeast Nebraska Cancer Center - 68th Street Place
-
Lincoln, Nebraska, United States, 68510
- Saint Elizabeth Regional Medical Center
-
Norfolk, Nebraska, United States, 68701
- Faith Regional Health Services Carson Cancer Center
-
North Platte, Nebraska, United States, 69101
- Great Plains Health Callahan Cancer Center
-
Omaha, Nebraska, United States, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, United States, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, United States, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, United States, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, United States, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, United States, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, United States, 68106
- Missouri Valley Cancer Consortium
-
Omaha, Nebraska, United States, 68124
- Nebraska Cancer Specialists - Omaha
-
Omaha, Nebraska, United States, 68130
- Oncology Hematology West PC
-
Omaha, Nebraska, United States, 68130
- Urology Cancer Center PC
-
Omaha, Nebraska, United States, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, United States, 68046
- Midlands Community Hospital
-
Scottsbluff, Nebraska, United States, 69361
- Regional West Medical Center Cancer Center
-
-
Nevada
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, United States, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, United States, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, United States, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, United States, 89074
- GenesisCare USA - Henderson
-
Las Vegas, Nevada, United States, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, United States, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, United States, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, United States, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, United States, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, United States, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, United States, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, United States, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, United States, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, United States, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, United States, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, United States, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, United States, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, United States, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, United States, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, United States, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, United States, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, United States, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, United States, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, United States, 89169
- Nevada Cancer Research Foundation NCORP
-
Reno, Nevada, United States, 89502
- Renown Regional Medical Center
-
-
New Jersey
-
Camden, New Jersey, United States, 08103
- Cooper Hospital University Medical Center
-
East Orange, New Jersey, United States, 07018-1095
- Veterans Adminstration New Jersey Health Care System
-
Hackensack, New Jersey, United States, 07601
- Hackensack University Medical Center
-
Morristown, New Jersey, United States, 07960
- Morristown Medical Center
-
Mullica Hill, New Jersey, United States, 08062
- Inspira Medical Center Mullica Hill
-
Newark, New Jersey, United States, 07101
- Rutgers New Jersey Medical School
-
Newark, New Jersey, United States, 07112
- Newark Beth Israel Medical Center
-
Summit, New Jersey, United States, 07902
- Overlook Hospital
-
Vineland, New Jersey, United States, 08360
- Inspira Medical Center Vineland
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87102
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, United States, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Las Cruces, New Mexico, United States, 88011
- Memorial Medical Center - Las Cruces
-
-
New York
-
Auburn, New York, United States, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Bronx, New York, United States, 10467
- Montefiore Medical Center - Moses Campus
-
Bronx, New York, United States, 10461
- Montefiore Medical Center-Weiler Hospital
-
Brooklyn, New York, United States, 11203
- Kings County Hospital
-
Brooklyn, New York, United States, 11209
- Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
-
Brooklyn, New York, United States, 11203
- State University of New York Downstate Medical Center
-
Buffalo, New York, United States, 14215
- Veterans Affairs Western New York Health Care System-Buffalo
-
Cooperstown, New York, United States, 13326
- Mary Imogene Bassett Hospital
-
East Syracuse, New York, United States, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, United States, 12801
- Glens Falls Hospital
-
Middletown, New York, United States, 10940
- Garnet Health Medical Center
-
New York, New York, United States, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, United States, 10003
- Mount Sinai Union Square
-
Syracuse, New York, United States, 13215
- Hematology Oncology Associates of Central New York-Onondaga Hill
-
Utica, New York, United States, 13502
- Faxton-Saint Luke's Healthcare
-
-
North Carolina
-
Charlotte, North Carolina, United States, 28204
- Novant Health Presbyterian Medical Center
-
Charlotte, North Carolina, United States, 28207
- Oncology Specialists of Charlotte
-
Charlotte, North Carolina, United States, 28262
- Southern Oncology Specialists-Charlotte
-
Charlotte, North Carolina, United States, 28207
- Novant Health Carolina Surgical - Randolph
-
Clinton, North Carolina, United States, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, United States, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, United States, 27534
- Wayne Memorial Hospital
-
Huntersville, North Carolina, United States, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, United States, 28078
- Southern Oncology Specialists-Huntersville
-
Jacksonville, North Carolina, United States, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kinston, North Carolina, United States, 28501
- Vidant Oncology-Kinston
-
Matthews, North Carolina, United States, 28105
- Matthews Radiation Oncology Center
-
Matthews, North Carolina, United States, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, United States, 28117
- Novant Health Cancer Institute - Mooresville
-
-
North Dakota
-
Bismarck, North Dakota, United States, 58501
- Sanford Bismarck Medical Center
-
Bismarck, North Dakota, United States, 58501
- Mid Dakota Clinic
-
Bismarck, North Dakota, United States, 58501
- Saint Alexius Medical Center
-
Grand Forks, North Dakota, United States, 58201
- Altru Cancer Center
-
Minot, North Dakota, United States, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron, Ohio, United States, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, United States, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, United States, 44203
- Summa Health System - Barberton Campus
-
Beachwood, Ohio, United States, 44122
- UHHS-Chagrin Highlands Medical Center
-
Bellefontaine, Ohio, United States, 43311
- Mary Rutan Hospital
-
Belpre, Ohio, United States, 45714
- Strecker Cancer Center-Belpre
-
Canton, Ohio, United States, 44708
- Cleveland Clinic Mercy Hospital
-
Canton, Ohio, United States, 44710
- Aultman Health Foundation
-
Chillicothe, Ohio, United States, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, United States, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, United States, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, United States, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, United States, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, United States, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, United States, 44106
- Case Western Reserve University
-
Cleveland, Ohio, United States, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, United States, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, United States, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, United States, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, United States, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, United States, 43228
- Doctors Hospital
-
Columbus, Ohio, United States, 43215
- Grant Medical Center
-
Columbus, Ohio, United States, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, United States, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, United States, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, United States, 45428
- Dayton Veterans Affairs Medical Center
-
Delaware, Ohio, United States, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, United States, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, United States, 43015
- Grady Memorial Hospital
-
Greenville, Ohio, United States, 45331
- Wayne Hospital
-
Lancaster, Ohio, United States, 43130
- Fairfield Medical Center
-
Lancaster, Ohio, United States, 43130
- Lancaster Radiation Oncology
-
Lima, Ohio, United States, 45801
- Saint Rita's Medical Center
-
Marietta, Ohio, United States, 45750
- Marietta Memorial Hospital
-
Mayfield Heights, Ohio, United States, 44124
- UH Seidman Cancer Center at Landerbrook Health Center
-
Mentor, Ohio, United States, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Mount Vernon, Ohio, United States, 43050
- Knox Community Hospital
-
Newark, Ohio, United States, 43055
- Licking Memorial Hospital
-
Newark, Ohio, United States, 43055
- Newark Radiation Oncology
-
Portsmouth, Ohio, United States, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, United States, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, United States, 45505
- Springfield Regional Medical Center
-
Troy, Ohio, United States, 45373
- Upper Valley Medical Center
-
Westerville, Ohio, United States, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, United States, 44145
- UHHS-Westlake Medical Center
-
Zanesville, Ohio, United States, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, United States, 73109
- Integris Southwest Medical Center
-
Oklahoma City, Oklahoma, United States, 73142
- Integris Cancer Institute of Oklahoma
-
Oklahoma City, Oklahoma, United States, 73120
- Cancer Care Associates
-
Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Salem, Oregon, United States, 97301
- Salem Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, United States, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Beaver, Pennsylvania, United States, 15009
- UPMC-Heritage Valley Health System Beaver
-
Bethlehem, Pennsylvania, United States, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, United States, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Danville, Pennsylvania, United States, 17822
- Geisinger Medical Center
-
Drexel Hill, Pennsylvania, United States, 19026
- Delaware County Memorial Hospital
-
East Stroudsburg, Pennsylvania, United States, 18301
- Pocono Medical Center
-
Greensburg, Pennsylvania, United States, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Hazleton, Pennsylvania, United States, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Johnstown, Pennsylvania, United States, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, United States, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, United States, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, United States, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Media, Pennsylvania, United States, 19063
- Riddle Memorial Hospital
-
Moon, Pennsylvania, United States, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Philadelphia, Pennsylvania, United States, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, United States, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, United States, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, United States, 19140
- Temple University Hospital
-
Pittsburgh, Pennsylvania, United States, 15212
- Allegheny General Hospital
-
Pittsburgh, Pennsylvania, United States, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, United States, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, United States, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, United States, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, United States, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, United States, 15236
- UPMC Jefferson Regional Radiation Oncology
-
Pittsburgh, Pennsylvania, United States, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, United States, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pittsburgh, Pennsylvania, United States, 15240
- VA Pittsburgh Healthcare System
-
Pottsville, Pennsylvania, United States, 17901
- Geisinger Cancer Services-Pottsville
-
Reading, Pennsylvania, United States, 19605
- Penn State Health Saint Joseph Medical Center
-
Sayre, Pennsylvania, United States, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, United States, 18510
- Scranton Hematology Oncology
-
Scranton, Pennsylvania, United States, 18501
- Mercy Hospital
-
Scranton, Pennsylvania, United States, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Seneca, Pennsylvania, United States, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, United States, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, United States, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Upland, Pennsylvania, United States, 19013
- Associates In Hematology Oncology PC-Upland
-
Washington, Pennsylvania, United States, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Chester, Pennsylvania, United States, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, United States, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, United States, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, United States, 17701
- UPMC Susquehanna
-
-
Rhode Island
-
Pawtucket, Rhode Island, United States, 02860
- Memorial Hospital of Rhode Island
-
Providence, Rhode Island, United States, 02908
- Roger Williams Medical Center
-
-
South Carolina
-
Boiling Springs, South Carolina, United States, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, United States, 29640
- Prisma Health Cancer Institute - Easley
-
Florence, South Carolina, United States, 29506
- McLeod Regional Medical Center
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, United States, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, United States, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greenwood, South Carolina, United States, 29646
- Self Regional Healthcare
-
Greer, South Carolina, United States, 29650
- Prisma Health Cancer Institute - Greer
-
Seneca, South Carolina, United States, 29672
- Prisma Health Cancer Institute - Seneca
-
-
South Dakota
-
Rapid City, South Dakota, United States, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, United States, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, United States, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, United States, 57104
- Sanford Cancer Center Oncology Clinic
-
Sioux Falls, South Dakota, United States, 57105
- Medical X-Ray Center
-
Sioux Falls, South Dakota, United States, 57117-5045
- Avera McKennan Hospital and University Health Center
-
-
Tennessee
-
Chattanooga, Tennessee, United States, 37404
- Memorial Hospital
-
Chattanooga, Tennessee, United States, 37403
- Erlanger Medical Center
-
Franklin, Tennessee, United States, 37067
- Vanderbilt-Ingram Cancer Center Cool Springs
-
Hixson, Tennessee, United States, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Knoxville, Tennessee, United States, 37920
- University of Tennessee - Knoxville
-
Nashville, Tennessee, United States, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, United States, 37208
- Meharry Medical College
-
Nashville, Tennessee, United States, 37203
- Nashville Oncology Associates PC
-
Ooltewah, Tennessee, United States, 37363
- Memorial GYN Plus
-
-
Texas
-
Houston, Texas, United States, 77030
- Houston Methodist Hospital
-
Houston, Texas, United States, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, United States, 77030
- Michael E DeBakey VA Medical Center
-
Houston, Texas, United States, 77030
- Ben Taub General Hospital
-
Houston, Texas, United States, 77030
- Baylor Saint Luke's Medical Center
-
Lubbock, Texas, United States, 79430
- Texas Tech University Health Sciences Center-Lubbock
-
San Antonio, Texas, United States, 78229
- University Hospital
-
San Antonio, Texas, United States, 78229
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, United States, 78229
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
-
San Antonio, Texas, United States, 78229
- Audie L Murphy VA Hospital
-
-
Utah
-
American Fork, Utah, United States, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, United States, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, United States, 84321
- Logan Regional Hospital
-
Murray, Utah, United States, 84107
- Intermountain Medical Center
-
Ogden, Utah, United States, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, United States, 84604
- Utah Valley Regional Medical Center
-
Saint George, Utah, United States, 84770
- Saint George Regional Medical Center
-
Salt Lake City, Utah, United States, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, United States, 84143
- LDS Hospital
-
-
Virginia
-
Danville, Virginia, United States, 24541
- Danville Regional Medical Center
-
Richmond, Virginia, United States, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
-
Washington
-
Bellingham, Washington, United States, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, United States, 98166
- Highline Medical Center-Main Campus
-
Enumclaw, Washington, United States, 98022
- Saint Elizabeth Hospital
-
Federal Way, Washington, United States, 98003
- Saint Francis Hospital
-
Issaquah, Washington, United States, 98029
- Swedish Cancer Institute-Issaquah
-
Kirkland, Washington, United States, 98033
- EvergreenHealth Medical Center
-
Lakewood, Washington, United States, 98499
- Saint Clare Hospital
-
Port Angeles, Washington, United States, 98362
- Olympic Medical Center
-
Renton, Washington, United States, 98055
- Valley Medical Center
-
Renton, Washington, United States, 98055
- Southlake Clinic
-
Seattle, Washington, United States, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, United States, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, United States, 98104
- Pacific Medical Center-First Hill
-
Tacoma, Washington, United States, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, United States, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
-
West Virginia
-
Charleston, West Virginia, United States, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, United States, 25701
- Edwards Comprehensive Cancer Center
-
Morgantown, West Virginia, United States, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, United States, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Antigo, Wisconsin, United States, 54409
- Langlade Hospital and Cancer Center
-
Burlington, Wisconsin, United States, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, United States, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, United States, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, United States, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond Du Lac, Wisconsin, United States, 54937
- Aurora Health Center-Fond du Lac
-
Green Bay, Wisconsin, United States, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, United States, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, United States, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, United States, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
-
Green Bay, Wisconsin, United States, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Johnson Creek, Wisconsin, United States, 53038
- UW Cancer Center Johnson Creek
-
Kenosha, Wisconsin, United States, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, United States, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, United States, 53792
- University of Wisconsin Carbone Cancer Center
-
Manitowoc, Wisconsin, United States, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, United States, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, United States, 54143
- Bay Area Medical Center
-
Marshfield, Wisconsin, United States, 54449
- Marshfield Medical Center-Marshfield
-
Marshfield, Wisconsin, United States, 54449
- Marshfield Medical Center
-
Mequon, Wisconsin, United States, 53097
- Ascension Columbia Saint Mary's Hospital Ozaukee
-
Milwaukee, Wisconsin, United States, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, United States, 53211
- Ascension Columbia Saint Mary's Hospital - Milwaukee
-
Minocqua, Wisconsin, United States, 54548
- Marshfield Clinic-Minocqua Center
-
New Richmond, Wisconsin, United States, 54017
- Cancer Center of Western Wisconsin
-
Oconto Falls, Wisconsin, United States, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, United States, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, United States, 53406
- Aurora Cancer Care-Racine
-
Racine, Wisconsin, United States, 53405
- Ascension All Saints Hospital
-
Rhinelander, Wisconsin, United States, 54501
- Ascension Saint Mary's Hospital
-
Rice Lake, Wisconsin, United States, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, United States, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, United States, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, United States, 54481
- Ascension Saint Michael's Hospital
-
Sturgeon Bay, Wisconsin, United States, 54235
- Green Bay Oncology - Sturgeon Bay
-
Summit, Wisconsin, United States, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, United States, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, United States, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, United States, 54401
- Aspirus Regional Cancer Center
-
Weston, Wisconsin, United States, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Casper, Wyoming, United States, 82609
- Rocky Mountain Oncology
-
Cheyenne, Wyoming, United States, 82001
- Cheyenne Regional Medical Center-West
-
Sheridan, Wyoming, United States, 82801
- Welch Cancer Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Patients must have histologically or cytologically confirmed squamous cell cancer of the head and neck (SCCHN), from any primary site, including unknown primary cancers of the head and neck; patient must not have nasopharyngeal carcinoma of histologic types World Health Organization (WHO) 2 or 3 or squamous cell carcinoma that originated in the skin
- Patients must have SCCHN that is either (a) recurrent, judged incurable by surgery or radiation or (b) metastatic; NOTE: Patients who refuse radical resection for recurrent disease are eligible; NOTE: A second primary squamous cell carcinoma of the head and neck is allowed if eligibility is based on a recurrent or metastatic first primary squamous cell carcinoma of the head and neck
No prior chemotherapy or biologic/molecular targeted therapy for recurrent or metastatic SCCHN
- Patients may have received one regimen of induction, concomitant chemoradiotherapy and/or adjuvant chemotherapy as part of initial potential curative therapy but must not have received prior chemotherapy for recurrent or metastatic disease
- A minimum of 4 months is required between last dose of chemotherapy or chemoradiotherapy and study treatment; in addition patients must be progression-free for at least 4 months after completion of chemotherapy or chemoradiotherapy or radiation plus cetuximab given with a curative intent; (cetuximab therapy: 4 months is required between last dose of chemotherapy or chemoradiotherapy and study treatment if part of concurrent regimen, 8 weeks if part of adjuvant regimen post radiation)
- Patients having progression after 2 cycles of induction chemotherapy are not eligible for the study
- No prior bevacizumab is allowed
- A maximum of one prior radiotherapy regimen, curative or palliative, to the head and neck is allowed; if the radiation is combined with chemotherapy and/or cetuximab, a minimum of 4 months must elapse between the end of radiotherapy and registration; if the radiation is given alone, a minimum of 8 weeks must elapse between the end of radiotherapy and registration; a minimum of 3 weeks must elapse between prior radiation to other areas and registration
- Patients must not be receiving any other investigational agent while on the study
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
- Patients must have recovered to grade 1 or better from any acute effects of prior surgery, chemotherapy, or radiation therapy, and should be > 4 weeks post surgery; chronic late xerostomia, speech and swallowing abnormalities resulting from prior radiation or surgery are permitted if nutritional status is stable
- Patients must have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST); baseline measurements and evaluations of all sites of disease must be obtained =< 4 weeks prior to randomization; disease in previously irradiated sites is considered measurable if there has been unequivocal disease progression or biopsy-proven residual carcinoma following radiation therapy; persistent disease after radiotherapy must be biopsy proven at least 8 weeks after completion of radiation therapy; (radiographic findings are acceptable providing that clear-cut measurements can be made)
- Absolute neutrophil count (ANC) >= 1500/mm^3
- Hemoglobin (Hgb) >= 8.0 g/dL
- Platelet count >= 100,000/mm^3
- Creatinine clearance of >= 60 ml/min; creatinine clearance may be measured or calculated; if calculating, creatinine clearance, use the Cockroft-Gault formula
- Total bilirubin within normal limits (must be obtained =< 2 weeks prior to randomization)
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) must be within the range allowing for eligibility
- Alkaline phosphatase normal AND AST or ALT =< 5 x upper limit of normal (ULN)
- Alkaline phosphatase > 1 but =< 2.5 x ULN AND AST or ALT > 1 but =< 1.5 x ULN
- Alkaline phosphatase > 2.5 but =< 5 x ULN AND AST or ALT normal
- Alkaline phosphatase must be within the range allowing for eligibility
- Urine dipstick must be =< 0-1+ within 2 weeks (14 days) of randomization; if urine dipstick result is > 1+, a calculation of urine protein creatinine (UPC) ratio is required; patients must have a UPC ratio < 1.0 to participate in the study; NOTE: UPC ratio of spot urine is an estimation of the 24 urine protein excretion - a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gm
- No known brain metastases
Patients who meet the following criteria will be excluded:
- Tumors that invade major vessels (e.g. the carotid) as shown unequivocally by imaging studies
- Central (i.e. within 2 cm from the hilum) lung metastases that are cavitary as shown unequivocally by imaging studies
- Any prior history of bleeding related to the current head and neck cancer
- History of gross hemoptysis (bright red blood of 1/2 teaspoon or more per episode of coughing) =< 3 months prior to enrollment
- No history of coagulopathy or hemorrhagic disorders
- Patients should not have a history of thrombosis (e.g. pulmonary embolism or deep venous thrombosis) currently requiring therapeutic anticoagulation (prophylactic use of warfarin 1 mg per day is allowed) and international normalized ratio (INR) should be < 1.5 at registration
- Patients must not be receiving chronic daily treatment with aspirin (> 325 mg/day) or non-steroidal anti-inflammatory agents (NSAID's) known to inhibit platelet function; the use of anti-platelet agents (e.g. dipyridamole [Persantine], ticlopidine [Ticlid], clopidogrel [Plavix]) is allowed only if patient is not receiving aspirin or NSAID's known to inhibit platelet function
- No hypercalcemia related to head and neck cancer
- Patients with a prior history of squamous cell or basal carcinoma of the skin or in situ cervical cancer must have been curatively treated; patients with a history of other prior malignancy must have been treated with curative intent and must have remained disease-free for 3 years post diagnosis
- No current peripheral neuropathy >= grade 2 at time of randomization
- Patients must not have any co-existing condition that would preclude full compliance with the study
- No prior history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80, if the physician's choice of chemotherapy regimen is docetaxel
- All patients must have blood pressure =< 150/90 =< 2 weeks prior to randomization; patients with history of hypertension must be well-controlled upon study entry (=< 150/90) on a stable regimen of anti-hypertensive therapy
- No major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study enrollment, or anticipation of need for major surgical procedure during the course of the study
- No unstable angina or myocardial infarction within the previous 6 months; no symptomatic congestive heart failure, New York Heart Association (NYHA) grade II or greater; no history of aortic dissection or presence of aneurysm > 6 cm (or at high risk for rupture); no serious cardiac arrhythmia requiring medication (history of chronic atrial fibrillation or other atrial arrhythmia with controlled rate on medication is allowed); no clinically significant peripheral vascular disease manifested by intermittent claudication or need for vascular intervention; no history of aortic dissection; no history of any central nervous system (CNS) cerebrovascular ischemia or stroke within the last 6 months; no active serious infection
- Patients should not have prior history of a serious human anti-human antibody (HAHA) reaction; patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies are not eligible
- Women must not be pregnant or breast feeding; pregnant women are excluded from this study; women of child-bearing potential and men must agree to total abstinence or to use adequate hormonal or barrier method of birth control prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while in this study, she should inform her treating physician immediately; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy
- Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study; appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicated
- No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to registration
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Active Comparator: Arm IA (docetaxel, cisplatin)
Patients receive docetaxel IV over 1 hour and cisplatin IV over 1-2 hours on day 1.
Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
|
Correlative studies
Given IV
Other Names:
Given IV
Other Names:
|
|
Experimental: Arm IB (docetaxel, cisplatin, bevacizumab)
Patients receive bevacizumab IV over 30-90 minutes on day 1 and docetaxel and cisplatin as in Arm IA.
|
Correlative studies
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
|
|
Active Comparator: Arm IIA (docetaxel, carboplatin)
Patients receive docetaxel IV over 1 hour and carboplatin IV over 30 minutes on day 1.
Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
|
Correlative studies
Given IV
Other Names:
Given IV
Other Names:
|
|
Experimental: Arm IIB (docetaxel, carboplatin, bevacizumab)
Patients receive bevacizumab as in Arm IB and docetaxel and carboplatin as in Arm IIA.
|
Correlative studies
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
|
|
Active Comparator: Arm IIIA (cisplatin, fluorouracil)
Patients receive cisplatin IV over 1-2 hours on day 1 and fluorouracil IV continuously on days 1-4.
Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
|
Correlative studies
Given IV
Other Names:
Given IV
Other Names:
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|
Experimental: Arm IIIB (cisplatin, fluorouracil, bevacizumab)
Patients receive bevacizumab as in Arm IB and cisplatin and fluorouracil as in Arm IIIA.
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Correlative studies
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
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Active Comparator: Arm IVA (carboplatin, fluorouracil)
Patients receive carboplatin IV over 30 minutes on day 1 and fluorouracil IV continuously on days 1-4.
Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
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Correlative studies
Given IV
Other Names:
Given IV
Other Names:
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Experimental: Arm IVB (carboplatin, fluorouracil, bevacizumab)
Patients receive bevacizumab as in Arm IB and carboplatin and fluorouracil as in Arm IVA.
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Correlative studies
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Overall Survival (OS)
Time Frame: assessed every 3 months within 2 years from study entry, then every 6 months up to 5 years from study entry
|
Overall survival (OS) was defined as time from randomization to death from any course.
Patients who were alive were censored at the last contact date.
Median OS was estimated using the Kaplan-Meier method.
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assessed every 3 months within 2 years from study entry, then every 6 months up to 5 years from study entry
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Progression-free Survival (PFS)
Time Frame: on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks
|
Progression was defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions.
Progression-free survival (PFS) was defined as the time from randomization to date of disease progression or death from any cause, whichever occurred first.
Patients who were still alive and progression free were censored at last disease assessment date.
Median PFS was estimated using Kaplan-Meier method.
|
on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks
|
|
Overall Response Rate
Time Frame: on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks
|
Overall response rate is defined as number of patients with complete response (CR) or partial response (PR) divided by all patients.
Responses are evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST) guideline.
CR is defined as disappearance of all target and non-target lesions.
PR is defined as disappearance of target lesions or at least a 30% decrease in the sum of the diameters of target lesions (taking as reference the baseline sum diameters), and persistence of one or more non-target lesion(s).
|
on both arms, assessed every 2 cycles during chemotherapy treatment, then assessed every 9 weeks until progression up to 5 years from study entry; patients on arm B were assessed every 2 cycles for additional 12 weeks before changing to every 9 weeks
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
To Collect Blood Samples Before and After Therapy for Future Correlative Studies
Time Frame: Before and after therapy
|
These were blood and tissue samples collections and have no data to report.
|
Before and after therapy
|
|
To Collect Tumor Tissue Samples Available at Baseline From Prior Diagnostic Procedures for Future Correlative Studies
Time Frame: Baseline
|
These were blood and tissue samples collections and have no data to report.
|
Baseline
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Athanassios (Ethan) Argiris, ECOG-ACRIN Cancer Research Group
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 8, 2008
Primary Completion (Actual)
June 5, 2018
Study Completion (Estimated)
February 22, 2025
Study Registration Dates
First Submitted
December 28, 2007
First Submitted That Met QC Criteria
December 28, 2007
First Posted (Estimated)
January 9, 2008
Study Record Updates
Last Update Posted (Actual)
April 4, 2024
Last Update Submitted That Met QC Criteria
April 3, 2024
Last Verified
February 1, 2024
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Neoplasms by Histologic Type
- Neoplasms
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Disease Attributes
- Stomatognathic Diseases
- Mouth Diseases
- Neoplastic Processes
- Neoplasm Metastasis
- Neoplasms, Squamous Cell
- Salivary Gland Diseases
- Head and Neck Neoplasms
- Carcinoma
- Recurrence
- Carcinoma, Squamous Cell
- Squamous Cell Carcinoma of Head and Neck
- Mouth Neoplasms
- Neoplasms, Unknown Primary
- Salivary Gland Neoplasms
- Carcinoma, Verrucous
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Antimetabolites, Antineoplastic
- Antimetabolites
- Antineoplastic Agents
- Immunosuppressive Agents
- Immunologic Factors
- Tubulin Modulators
- Antimitotic Agents
- Mitosis Modulators
- Angiogenesis Inhibitors
- Angiogenesis Modulating Agents
- Growth Substances
- Growth Inhibitors
- Docetaxel
- Carboplatin
- Antibodies
- Cisplatin
- Fluorouracil
- Immunoglobulins
- Bevacizumab
- Antibodies, Monoclonal
- Antineoplastic Agents, Immunological
- Immunoglobulin G
- Endothelial Growth Factors
Other Study ID Numbers
- NCI-2009-00507 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180820 (U.S. NIH Grant/Contract)
- U10CA021115 (U.S. NIH Grant/Contract)
- E1305 (Other Identifier: CTEP)
- CDR0000582533
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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