Safety and Tolerability of Levetiracetam Intravenous 15 Minute Infusion in Subjects Suffering From Partial Onset Seizures

Inclusion Criteria:

• Adult
• in- or out-subjects suffering from partial onset seizures according to the ILAE classification of Epileptic Seizures;
• intake of levetiracetam as an adjunctive antiepileptic oral treatment in addition to one or two antiepileptic drugs (AED).

Exclusion Criteria:

• Had problems of venous accessibility;
• showed safety issues related to the administration of one of the concomitant AEDs requiring medical intervention;
• clinically significant ECG/lab abnormalities;
• administered vigabatrine;
• administered felbamate for less than 18 months;
• had contraindication to any component of the study medication treatment as IV formulation or known allergic reaction to or intolerance of pyrrolidone derivatives.