Bioenergetic Alterations After Exenatide Administration

Inclusion Criteria:

• 18-65 years of age
• BMI between 30 and 40 kg/m2
• Women with a negative pregnancy test at baseline, who are sterile, using contraceptives or in a committed relationship with someone who is sterile or using contraception
• Absence of weight change greater than 3 kg in the previous 6 months

Exclusion Criteria:

• Women who are pregnant or lactating
• Current or recent (6 months) enrollment in a commercial or self prescribed weight loss or exercise program
• Use of weight loss medication
• A history of metabolic disease i.e. renal, endocrine, hepatic or gastrointestinal disease that would impact the outcome of the study
• Presence of medical conditions that are known to affect energy expenditure (i.e. hyperthyroidism, rheumatoid arthritis, AIDS among others)
• History of hypoglycemia
• A history of psychiatric or eating disorder
• Abnormal EKG
• Previous history of pancreatitis
• Previous history of gastroparesis or GI motility disorder
• Use of medications that can affect GI motility
• History of organ transplantation
• Other comorbid conditions which may preclude the subject's ability to complete the study
• Use of a carbonic anhydrase inhibitor such as acetazolamide