Crossover Blinded Trial of Cell Therapy Versus Placebo in COPD
연구 개요
상세 설명
The purpose of the Lung Institute is to collect, minimally process, and administer a person's own stem cells and/or platelet rich plasma and deliver the product back to the patient same-day through an intravenous catheter. This study is limited to patients diagnosed with chronic obstructive pulmonary disease (COPD) and is a double-blinded prospective, cohort trial using cross-over methodology. The aim of this study is to determine if stem cell therapy is better than placebo among a group of patients with COPD.
50 participants will be recruited for each arm of the study.
Cohort A will receive three days of cell therapy using the venous procedure (three consecutive days of blood harvest, cell separation and cell application). Cohort A will return in three months and receive three consecutive days of placebo.
Cohort B will receive three consecutive days of placebo. Cohort B will return in three months and receive three consecutive days of cell therapy using the venous procedure.
연구 유형
단계
- 해당 없음
연락처 및 위치
연구 장소
-
-
Texas
-
Dallas, Texas, 미국, 75231
- Lung Institute Dallas
-
-
참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Patients are included in treatment by self-referral and after consultation with a designated patient coordinator who determines initial eligibility, and then by the clinic nurse practitioner or physician of Lung Institute who determines final eligibility for inclusion. Patients must be diagnosed with chronic obstructive pulmonary disease (COPD) and be able to travel to the Dallas clinic location.
Exclusion Criteria:
- Patients who are unable to provide informed consent, pregnant patients, prisoners, non-English speakers, patients with a history of cancer within the past 5 years, patients with active tuberculosis or pneumonia. Patients without a documented COPD diagnosis are excluded.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 더블
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
|
실험적: Cohort A
Cohort A (Treatment Then Placebo group) will receive three days of cell therapy using the venous procedure (three consecutive days of blood harvest, cell separation and cell application).
Cohort A will return in three months and receive three consecutive days of placebo.
|
Cohort A will receive stem cells/PRP infusion during round one then placebo of normal saline infusion during round two.
|
|
실험적: Cohort B
Cohort B (Placebo Then Treatment group) will receive three consecutive days of placebo.
Cohort B will return in three months and receive three consecutive days of cell therapy using the venous procedure.
|
Cohort B will receive placebo of normal saline infusion during round one then stem cells/PRP infusion during round two.
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Change in Quality of Life Score
기간: 3 months, 6 months following each treatment
|
Change in QOL score from baseline to 3 months and 6 months following each treatment
|
3 months, 6 months following each treatment
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Change in FEV1
기간: 6 months following each treatment
|
Change in FEV1 from baseline to 6 months post-treatment
|
6 months following each treatment
|
공동 작업자 및 조사자
스폰서
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
COPD에 대한 임상 시험
-
Ryme Medical, Inc.아직 모집하지 않음COPD | 폐질환, 만성 폐쇄성 | COPD 환자 | COPD 급성 악화 | COPD(만성폐쇄성폐질환) | 폐 질환 항공 | COPD 악화
-
Insel Gruppe AG, University Hospital BernUniversity Hospital, Geneva; Cantonal Hospital St. Gallen, Switzerland아직 모집하지 않음
-
Istituto Nazionale di Ricovero e Cura per Anziani모병
-
Bio-Sensing Solutions S.L. (DyCare)Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau; Centre de Validació...모병
-
The First Affiliated Hospital of Guangzhou Medical...모병
-
Association des Réseaux BronchioliteLaboratoire Système et Matériaux pour la Mécatronique (SYMME)모병
-
Polytechnic Institute of PortoNippon Gases Portugal모병
Treatment Then Placebo에 대한 임상 시험
-
Fondazione I.R.C.C.S. Istituto Neurologico Carlo...모병
-
Riphah International University모병
-
Newish Biotech (Wuxi) Co., Ltd.아직 모집하지 않음
-
Chiesi Farmaceutici S.p.A.아직 모집하지 않음
-
Nature's Sunshine Products, Inc.아직 모집하지 않음