Eating Behavior, Nutritional Status and Appetite Hormones After Bariatric Surgery (BCKYL-YDB)
2026년 6월 2일 업데이트: Özlem ÖZPAK AKKUŞ
Evaluation of Changes in Postoperative Eating Behavior Attitudes, Nutritional Status, and Some Hormonal Parameters Regulating Appetite in Surgical Weight Management
This study aims to evaluate changes in eating behavior attitudes, nutritional status, and appetite-regulating hormonal parameters in individuals who have undergone Laparoscopic Sleeve Gastrectomy (LSG).
The study will be conducted at Bursa Yıldırım Doruk Hospital, Department of General Surgery.
A total of 40 volunteer participants who underwent LSG within the last month will be included.
Participants will be assessed at baseline (shortly after surgery) and at 6-month follow-up.
Assessments will include anthropometric measurements (body weight, height, waist and hip circumference, BMI, waist-to-hip ratio), 3-day dietary intake records analyzed using BeBIS 8.2 software, and the Adult Eating Behavior Scale.
Biochemical parameters including fasting blood glucose, total cholesterol, triglycerides, HDL, LDL, VLDL cholesterol, and insulin will be obtained from patient files and analyzed using Advia Chemistry 2400 and Advia XPT devices.
Additionally, appetite-regulating hormones (ghrelin, GLP-1, PYY) will be analyzed from residual blood samples using the ELISA method with RelAssay Diagnostics kits by Teknogen Bioengineering Laboratory.
All data will be compared between baseline and 6-month follow-up to evaluate the impact of bariatric surgery on nutritional and hormonal outcomes.
연구 개요
상태
아직 모집하지 않음
정황
상세 설명
This observational study will be conducted at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, under the supervision of Assoc. Prof. Dogukan Durak. Forty volunteer participants who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month and meet the inclusion and exclusion criteria will be enrolled after signing an informed consent form.
Assessments will be performed at two time points: at baseline (shortly after surgery) and at 6-month follow-up.
Anthropometric Measurements: Body weight, height, waist and hip circumference will be measured. BMI and waist-to-hip ratio will be calculated accordingly. Waist circumference will be evaluated according to WHO criteria.
Dietary Assessment: A 3-day dietary intake record will be collected from each participant at both time points. Food portion sizes will be estimated using the "Food and Nutrient Photo Catalog." Energy and macronutrient intake will be analyzed using BeBIS 8.2 software and evaluated according to the Turkish Dietary Guidelines 2022 (TUBER 2022).
Eating Behavior Assessment: The Adult Eating Behavior Scale (developed by Celik et al.) will be administered at both time points. The scale consists of 18 items and 5 subscales, scored between 0-100. Higher scores indicate more positive attitudes toward eating behavior.
Biochemical and Hormonal Parameters: After 12-hour fasting, the following biochemical parameters will be obtained from patient files: fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, and insulin. Routine biochemical parameters and lipid profile will be analyzed spectrophotometrically using the Advia Chemistry 2400 device, while insulin will be measured by chemiluminescence using the Advia XPT device. Additionally, appetite-regulating hormones including ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) will be analyzed from residual blood samples stored at -20°C by Teknogen Bioengineering Laboratory using the ELISA method with an automated microplate reader (Biotek TS800) and RelAssay Diagnostics commercial kits (Ankara, Turkey).
All data will be compared between baseline and 6-month follow-up using appropriate statistical methods.
연구 유형
관찰
등록 (추정된)
40
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 연락처
- 이름: Özlem ÖZPAK AKKUŞ, Assoc. Prof.
- 전화번호: +903246253300
- 이메일: dytozlemozpak@hotmail.com
연구 연락처 백업
- 이름: Doğukan DURAK, Assoc. Prof.
- 전화번호: +905327243733
- 이메일: dogukandurak404@hotmail.com
연구 장소
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Bursa
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Bursa, Bursa, 터키 (Türkiye), 16130
- Bursa Yıldırım Doruk Hastanesi, General Surgery Clinic
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연락하다:
- Özlem ÖZPAK AKKUŞ, Assoc. Prof.
- 전화번호: +903246253300
- 이메일: dytozlemozpak@hotmail.com
-
연락하다:
- Doğukan DURAK, Assoc. Prof.
- 전화번호: +905327243733
- 이메일: dogukandurak404@hotmail.com
-
수석 연구원:
- Özlem ÖZPAK AKKUŞ, Assoc. Prof.
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부수사관:
- Doğukan Durak, Assoc. Prof.
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부수사관:
- Seher ŞEN, Asst. Prof.
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부수사관:
- Tuğçe Nur DOĞANAY YILDIRIM, MSc, RD
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참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
- 성인
건강한 자원 봉사자를 받아들입니다
아니
샘플링 방법
비확률 샘플
연구 인구
Adult patients who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, under the supervision of Assoc.
Prof. Dogukan Durak, and who meet the inclusion and exclusion criteria.
설명
Inclusion Criteria:
- Having undergone Laparoscopic Sleeve Gastrectomy (LSG) within the last month
- Aged between 18-50 years
- Signing the informed consent form
- Having a Body Mass Index (BMI) of 40 kg/m2 or between 35-40 kg/m2 with obesity-related comorbidities
- No diagnosis of depression
- No eating behavior disorder
- No psychiatric disorder
Exclusion Criteria:
- Not having undergone Laparoscopic Sleeve Gastrectomy (LSG) or not planning to undergo bariatric surgery
- Not being in the age range of 18-50 years
- Not signing the informed consent form
- Having a Body Mass Index (BMI) greater than 40 kg/m2 or less than 35 kg/m2 without obesity-related comorbidities
- Having a diagnosis of depression
- Having an eating behavior disorder
- Having a psychiatric disorder
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
코호트 및 개입
그룹/코호트 |
개입 / 치료 |
|---|---|
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LSG Patients
Individuals who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, and meet the inclusion and exclusion criteria.
Participants will be assessed at baseline (shortly after surgery) and at 6-month follow-up.
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Anthropometric measurements (body weight, height, waist and hip circumference, BMI, waist-to-hip ratio), 3-day dietary intake records, Adult Eating Behavior Scale, and biochemical and hormonal parameters (fasting blood glucose, lipid profile, insulin, ghrelin, GLP-1, PYY) will be assessed at baseline and at 6-month follow-up.
다른 이름들:
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Change in Serum Ghrelin Concentration (pg/mL)
기간: Baseline and 6 months after surgery
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Change in serum ghrelin levels between baseline and 6-month follow-up, assessed by ELISA method.
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Baseline and 6 months after surgery
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Change in Serum GLP-1 Concentration (pmol/L)
기간: Baseline and 6 months after surgery
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Change in serum glucagon-like peptide-1 (GLP-1) levels between baseline and 6-month follow-up, assessed by ELISA method.
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Baseline and 6 months after surgery
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Change in Serum PYY Concentration (pg/mL)
기간: Baseline and 6 months after surgery
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Change in serum peptide YY (PYY) levels between baseline and 6-month follow-up, assessed by ELISA method.
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Baseline and 6 months after surgery
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Change in Adult Eating Behavior Scale Total Score (0-100)
기간: Baseline and 6 months after surgery
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Change in Adult Eating Behavior Scale total score between baseline and 6-month follow-up.
Scale is scored between 0-100; higher scores indicate more positive eating behavior attitudes.
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Baseline and 6 months after surgery
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Change in Daily Energy Intake (kcal/day)
기간: Baseline and 6 months after surgery
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Change in daily energy intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.
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Baseline and 6 months after surgery
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Change in Daily Protein Intake (g/day)
기간: Baseline and 6 months after surgery
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Change in daily protein intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022
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Baseline and 6 months after surgery
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Change in Daily Carbohydrate Intake (g/day)
기간: Baseline and 6 months after surgery
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Change in daily carbohydrate intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.
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Baseline and 6 months after surgery
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Change in Daily Fat Intake (g/day)
기간: Baseline and 6 months after surgery
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Change in daily fat intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.
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Baseline and 6 months after surgery
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Change in Body Weight (kg)
기간: Baseline and 6 months after surgery
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Change in body weight between baseline and 6-month follow-up.
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Baseline and 6 months after surgery
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Change in Body Mass Index (kg/m²)
기간: Baseline and 6 months after surgery
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Change in BMI between baseline and 6-month follow-up.
Weight and height will be combined to report BMI in kg/m².
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Baseline and 6 months after surgery
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Change in Waist Circumference (cm)
기간: Baseline and 6 months after surgery
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Change in waist circumference between baseline and 6-month follow-up.
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Baseline and 6 months after surgery
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Change in Hip Circumference (cm)
기간: Baseline and 6 months after surgery
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Change in hip circumference between baseline and 6-month follow-up.
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Baseline and 6 months after surgery
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Change in Waist-to-Hip Ratio
기간: Baseline and 6 months after surgery
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Change in waist-to-hip ratio between baseline and 6-month follow-up.
Waist and hip circumference measurements will be combined to calculate the waist-to-hip ratio.
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Baseline and 6 months after surgery
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Change in Fasting Blood Glucose Concentration (mg/dL)
기간: Baseline and 6 months after surgery
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Change in fasting blood glucose levels between baseline and 6-month follow-up.
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Baseline and 6 months after surgery
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Change in Total Cholesterol Concentration (mg/dL)
기간: Baseline and 6 months after surgery
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Change in total cholesterol levels between baseline and 6-month follow-up.
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Baseline and 6 months after surgery
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Change in Triglyceride Concentration (mg/dL)
기간: Baseline and 6 months after surgery
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Change in triglyceride levels between baseline and 6-month follow-up.
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Baseline and 6 months after surgery
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Change in HDL Cholesterol Concentration (mg/dL)
기간: Baseline and 6 months after surgery
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Change in high-density lipoprotein (HDL) cholesterol levels between baseline and 6-month follow-up.
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Baseline and 6 months after surgery
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Change in LDL Cholesterol Concentration (mg/dL)
기간: Baseline and 6 months after surgery
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Change in low-density lipoprotein (LDL) cholesterol levels between baseline and 6-month follow-up.
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Baseline and 6 months after surgery
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Change in VLDL Cholesterol Concentration (mg/dL)
기간: Baseline and 6 months after surgery
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Change in very low-density lipoprotein (VLDL) cholesterol levels between baseline and 6-month follow-up.
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Baseline and 6 months after surgery
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Change in Fasting Insulin Concentration (µIU/mL)
기간: Baseline and 6 months after surgery
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Change in fasting insulin levels between baseline and 6-month follow-up.
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Baseline and 6 months after surgery
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공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
수사관
- 수석 연구원: Özlem ÖZPAK AKKUŞ, Assoc. Prof., Toros University
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
일반 간행물
- Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995;854:1-452.
- Sherf Dagan S, Goldenshluger A, Globus I, Schweiger C, Kessler Y, Kowen Sandbank G, Ben-Porat T, Sinai T. Nutritional Recommendations for Adult Bariatric Surgery Patients: Clinical Practice. Adv Nutr. 2017 Mar 15;8(2):382-394. doi: 10.3945/an.116.014258. Print 2017 Mar.
- Celik E, Karabulut E, Bilgic P. Bariatrik Cerrahi Hastalarinda Beslenme ve Davranis Tutumu Olcegi. Bes Diy Derg. 2017;45(2):107-15.
- Pekcan G, Sanlier N, Bas M, Acar Tek N, Gokmen Ozel H. Turkiye Beslenme Rehberi (TUBER) 2022. Ankara: Hazar Reklamcilik; 2022.
- Beslenme Bilgi Sistemleri Paket Programi (BeBIS 8.2). Istanbul: Software NDB; 2015.
- Merdol TK. Toplu Beslenme Yapilan Kurumlar icin Standard Yemek Tarifleri. Hatipoglu Yayinlari; 2003.
- Rakicioglu N, Tek NA, Ayaz A, Pekcan G. Yemek ve Besin Fotograf Katalogu Olcu ve Miktarlar. Nadir Kitap; 2012.
- Pekcan G. Beslenme Durumunun Saptanmasi. Diyet El Kitabi. Ankara: Hatipoglu Yayinevi; 2013:67-142.
- Baltaci G. Obezite ve egzersiz. Saglik Bakanligi Yayinlari, Ankara; 2008.
- World Health Organization. Prevention and management of the global epidemic of obesity. Report of the WHO Consultation on Obesity. Geneva: WHO; 1997.
- Rigamonti AE, Bini S, Rocco MC, Giardini V, Massimini D, Crippa MG, Saluzzi A, Casati M, Marazzi N, Perotti M, Cimino V, Grassi G, Sartorio A, Pincelli AI. Post-prandial anorexigenic gut peptide, appetite and glucometabolic responses at different eating rates in obese patients undergoing laparoscopic sleeve gastrectomy. Endocrine. 2017 Jan;55(1):113-123. doi: 10.1007/s12020-016-0933-6. Epub 2016 Mar 29.
- Devlin MJ, Goldfein JA, Flancbaum L, Bessler M, Eisenstadt R. Surgical management of obese patients with eating disorders: a survey of current practice. Obes Surg. 2004 Oct;14(9):1252-7. doi: 10.1381/0960892042386940.
- Brown W, Dixon JB, Brien PO. Management of obesity--the role of surgery. Aust Fam Physician. 2006 Aug;35(8):584-6.
- Katsanos CS, Madura JA 2nd, Roust LR. Essential amino acid ingestion as an efficient nutritional strategy for the preservation of muscle mass following gastric bypass surgery. Nutrition. 2016 Jan;32(1):9-13. doi: 10.1016/j.nut.2015.07.005. Epub 2015 Aug 5.
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (추정된)
2026년 7월 1일
기본 완료 (추정된)
2027년 1월 1일
연구 완료 (추정된)
2027년 2월 1일
연구 등록 날짜
최초 제출
2026년 5월 20일
QC 기준을 충족하는 최초 제출
2026년 6월 2일
처음 게시됨 (실제)
2026년 6월 9일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
2026년 6월 9일
QC 기준을 충족하는 마지막 업데이트 제출
2026년 6월 2일
마지막으로 확인됨
2026년 6월 1일
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- BCKLY-YDB-2026
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
아니요
IPD 계획 설명
Individual participant data will not be shared due to patient privacy and confidentiality concerns in accordance with Turkish Personal Data Protection Law (KVKK).
Aggregate study results will be made available through peer-reviewed publication.
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
아니
미국 FDA 규제 기기 제품 연구
아니
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .