Eating Behavior, Nutritional Status and Appetite Hormones After Bariatric Surgery (BCKYL-YDB)
2026年6月2日 更新者：Özlem ÖZPAK AKKUŞ
Evaluation of Changes in Postoperative Eating Behavior Attitudes, Nutritional Status, and Some Hormonal Parameters Regulating Appetite in Surgical Weight Management
This study aims to evaluate changes in eating behavior attitudes, nutritional status, and appetite-regulating hormonal parameters in individuals who have undergone Laparoscopic Sleeve Gastrectomy (LSG).
The study will be conducted at Bursa Yıldırım Doruk Hospital, Department of General Surgery.
A total of 40 volunteer participants who underwent LSG within the last month will be included.
Participants will be assessed at baseline (shortly after surgery) and at 6-month follow-up.
Assessments will include anthropometric measurements (body weight, height, waist and hip circumference, BMI, waist-to-hip ratio), 3-day dietary intake records analyzed using BeBIS 8.2 software, and the Adult Eating Behavior Scale.
Biochemical parameters including fasting blood glucose, total cholesterol, triglycerides, HDL, LDL, VLDL cholesterol, and insulin will be obtained from patient files and analyzed using Advia Chemistry 2400 and Advia XPT devices.
Additionally, appetite-regulating hormones (ghrelin, GLP-1, PYY) will be analyzed from residual blood samples using the ELISA method with RelAssay Diagnostics kits by Teknogen Bioengineering Laboratory.
All data will be compared between baseline and 6-month follow-up to evaluate the impact of bariatric surgery on nutritional and hormonal outcomes.
研究概览
详细说明
This observational study will be conducted at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, under the supervision of Assoc. Prof. Dogukan Durak. Forty volunteer participants who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month and meet the inclusion and exclusion criteria will be enrolled after signing an informed consent form.
Assessments will be performed at two time points: at baseline (shortly after surgery) and at 6-month follow-up.
Anthropometric Measurements: Body weight, height, waist and hip circumference will be measured. BMI and waist-to-hip ratio will be calculated accordingly. Waist circumference will be evaluated according to WHO criteria.
Dietary Assessment: A 3-day dietary intake record will be collected from each participant at both time points. Food portion sizes will be estimated using the "Food and Nutrient Photo Catalog." Energy and macronutrient intake will be analyzed using BeBIS 8.2 software and evaluated according to the Turkish Dietary Guidelines 2022 (TUBER 2022).
Eating Behavior Assessment: The Adult Eating Behavior Scale (developed by Celik et al.) will be administered at both time points. The scale consists of 18 items and 5 subscales, scored between 0-100. Higher scores indicate more positive attitudes toward eating behavior.
Biochemical and Hormonal Parameters: After 12-hour fasting, the following biochemical parameters will be obtained from patient files: fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, and insulin. Routine biochemical parameters and lipid profile will be analyzed spectrophotometrically using the Advia Chemistry 2400 device, while insulin will be measured by chemiluminescence using the Advia XPT device. Additionally, appetite-regulating hormones including ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) will be analyzed from residual blood samples stored at -20°C by Teknogen Bioengineering Laboratory using the ELISA method with an automated microplate reader (Biotek TS800) and RelAssay Diagnostics commercial kits (Ankara, Turkey).
All data will be compared between baseline and 6-month follow-up using appropriate statistical methods.
研究类型
观察性的
注册 (估计的)
40
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Özlem ÖZPAK AKKUŞ, Assoc. Prof.
- 电话号码：+903246253300
- 邮箱：dytozlemozpak@hotmail.com
研究联系人备份
- 姓名：Doğukan DURAK, Assoc. Prof.
- 电话号码：+905327243733
- 邮箱：dogukandurak404@hotmail.com
学习地点
-
-
Bursa
-
Bursa、Bursa、土耳其（türkiye）、16130
- Bursa Yıldırım Doruk Hastanesi, General Surgery Clinic
-
接触：
- Özlem ÖZPAK AKKUŞ, Assoc. Prof.
- 电话号码：+903246253300
- 邮箱：dytozlemozpak@hotmail.com
-
接触：
- Doğukan DURAK, Assoc. Prof.
- 电话号码：+905327243733
- 邮箱：dogukandurak404@hotmail.com
-
首席研究员：
- Özlem ÖZPAK AKKUŞ, Assoc. Prof.
-
副研究员：
- Doğukan Durak, Assoc. Prof.
-
副研究员：
- Seher ŞEN, Asst. Prof.
-
副研究员：
- Tuğçe Nur DOĞANAY YILDIRIM, MSc, RD
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
接受健康志愿者
不
取样方法
非概率样本
研究人群
Adult patients who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, under the supervision of Assoc.
Prof. Dogukan Durak, and who meet the inclusion and exclusion criteria.
描述
Inclusion Criteria:
- Having undergone Laparoscopic Sleeve Gastrectomy (LSG) within the last month
- Aged between 18-50 years
- Signing the informed consent form
- Having a Body Mass Index (BMI) of 40 kg/m2 or between 35-40 kg/m2 with obesity-related comorbidities
- No diagnosis of depression
- No eating behavior disorder
- No psychiatric disorder
Exclusion Criteria:
- Not having undergone Laparoscopic Sleeve Gastrectomy (LSG) or not planning to undergo bariatric surgery
- Not being in the age range of 18-50 years
- Not signing the informed consent form
- Having a Body Mass Index (BMI) greater than 40 kg/m2 or less than 35 kg/m2 without obesity-related comorbidities
- Having a diagnosis of depression
- Having an eating behavior disorder
- Having a psychiatric disorder
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
LSG Patients
Individuals who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, and meet the inclusion and exclusion criteria.
Participants will be assessed at baseline (shortly after surgery) and at 6-month follow-up.
|
Anthropometric measurements (body weight, height, waist and hip circumference, BMI, waist-to-hip ratio), 3-day dietary intake records, Adult Eating Behavior Scale, and biochemical and hormonal parameters (fasting blood glucose, lipid profile, insulin, ghrelin, GLP-1, PYY) will be assessed at baseline and at 6-month follow-up.
其他名称：
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Change in Serum Ghrelin Concentration (pg/mL)
大体时间：Baseline and 6 months after surgery
|
Change in serum ghrelin levels between baseline and 6-month follow-up, assessed by ELISA method.
|
Baseline and 6 months after surgery
|
|
Change in Serum GLP-1 Concentration (pmol/L)
大体时间：Baseline and 6 months after surgery
|
Change in serum glucagon-like peptide-1 (GLP-1) levels between baseline and 6-month follow-up, assessed by ELISA method.
|
Baseline and 6 months after surgery
|
|
Change in Serum PYY Concentration (pg/mL)
大体时间：Baseline and 6 months after surgery
|
Change in serum peptide YY (PYY) levels between baseline and 6-month follow-up, assessed by ELISA method.
|
Baseline and 6 months after surgery
|
|
Change in Adult Eating Behavior Scale Total Score (0-100)
大体时间：Baseline and 6 months after surgery
|
Change in Adult Eating Behavior Scale total score between baseline and 6-month follow-up.
Scale is scored between 0-100; higher scores indicate more positive eating behavior attitudes.
|
Baseline and 6 months after surgery
|
|
Change in Daily Energy Intake (kcal/day)
大体时间：Baseline and 6 months after surgery
|
Change in daily energy intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.
|
Baseline and 6 months after surgery
|
|
Change in Daily Protein Intake (g/day)
大体时间：Baseline and 6 months after surgery
|
Change in daily protein intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022
|
Baseline and 6 months after surgery
|
|
Change in Daily Carbohydrate Intake (g/day)
大体时间：Baseline and 6 months after surgery
|
Change in daily carbohydrate intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.
|
Baseline and 6 months after surgery
|
|
Change in Daily Fat Intake (g/day)
大体时间：Baseline and 6 months after surgery
|
Change in daily fat intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.
|
Baseline and 6 months after surgery
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Change in Body Weight (kg)
大体时间：Baseline and 6 months after surgery
|
Change in body weight between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Body Mass Index (kg/m²)
大体时间：Baseline and 6 months after surgery
|
Change in BMI between baseline and 6-month follow-up.
Weight and height will be combined to report BMI in kg/m².
|
Baseline and 6 months after surgery
|
|
Change in Waist Circumference (cm)
大体时间：Baseline and 6 months after surgery
|
Change in waist circumference between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Hip Circumference (cm)
大体时间：Baseline and 6 months after surgery
|
Change in hip circumference between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Waist-to-Hip Ratio
大体时间：Baseline and 6 months after surgery
|
Change in waist-to-hip ratio between baseline and 6-month follow-up.
Waist and hip circumference measurements will be combined to calculate the waist-to-hip ratio.
|
Baseline and 6 months after surgery
|
|
Change in Fasting Blood Glucose Concentration (mg/dL)
大体时间：Baseline and 6 months after surgery
|
Change in fasting blood glucose levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Total Cholesterol Concentration (mg/dL)
大体时间：Baseline and 6 months after surgery
|
Change in total cholesterol levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Triglyceride Concentration (mg/dL)
大体时间：Baseline and 6 months after surgery
|
Change in triglyceride levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in HDL Cholesterol Concentration (mg/dL)
大体时间：Baseline and 6 months after surgery
|
Change in high-density lipoprotein (HDL) cholesterol levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in LDL Cholesterol Concentration (mg/dL)
大体时间：Baseline and 6 months after surgery
|
Change in low-density lipoprotein (LDL) cholesterol levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in VLDL Cholesterol Concentration (mg/dL)
大体时间：Baseline and 6 months after surgery
|
Change in very low-density lipoprotein (VLDL) cholesterol levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Fasting Insulin Concentration (µIU/mL)
大体时间：Baseline and 6 months after surgery
|
Change in fasting insulin levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员：Özlem ÖZPAK AKKUŞ, Assoc. Prof.、Toros University
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995;854:1-452.
- Sherf Dagan S, Goldenshluger A, Globus I, Schweiger C, Kessler Y, Kowen Sandbank G, Ben-Porat T, Sinai T. Nutritional Recommendations for Adult Bariatric Surgery Patients: Clinical Practice. Adv Nutr. 2017 Mar 15;8(2):382-394. doi: 10.3945/an.116.014258. Print 2017 Mar.
- Celik E, Karabulut E, Bilgic P. Bariatrik Cerrahi Hastalarinda Beslenme ve Davranis Tutumu Olcegi. Bes Diy Derg. 2017;45(2):107-15.
- Pekcan G, Sanlier N, Bas M, Acar Tek N, Gokmen Ozel H. Turkiye Beslenme Rehberi (TUBER) 2022. Ankara: Hazar Reklamcilik; 2022.
- Beslenme Bilgi Sistemleri Paket Programi (BeBIS 8.2). Istanbul: Software NDB; 2015.
- Merdol TK. Toplu Beslenme Yapilan Kurumlar icin Standard Yemek Tarifleri. Hatipoglu Yayinlari; 2003.
- Rakicioglu N, Tek NA, Ayaz A, Pekcan G. Yemek ve Besin Fotograf Katalogu Olcu ve Miktarlar. Nadir Kitap; 2012.
- Pekcan G. Beslenme Durumunun Saptanmasi. Diyet El Kitabi. Ankara: Hatipoglu Yayinevi; 2013:67-142.
- Baltaci G. Obezite ve egzersiz. Saglik Bakanligi Yayinlari, Ankara; 2008.
- World Health Organization. Prevention and management of the global epidemic of obesity. Report of the WHO Consultation on Obesity. Geneva: WHO; 1997.
- Rigamonti AE, Bini S, Rocco MC, Giardini V, Massimini D, Crippa MG, Saluzzi A, Casati M, Marazzi N, Perotti M, Cimino V, Grassi G, Sartorio A, Pincelli AI. Post-prandial anorexigenic gut peptide, appetite and glucometabolic responses at different eating rates in obese patients undergoing laparoscopic sleeve gastrectomy. Endocrine. 2017 Jan;55(1):113-123. doi: 10.1007/s12020-016-0933-6. Epub 2016 Mar 29.
- Devlin MJ, Goldfein JA, Flancbaum L, Bessler M, Eisenstadt R. Surgical management of obese patients with eating disorders: a survey of current practice. Obes Surg. 2004 Oct;14(9):1252-7. doi: 10.1381/0960892042386940.
- Brown W, Dixon JB, Brien PO. Management of obesity--the role of surgery. Aust Fam Physician. 2006 Aug;35(8):584-6.
- Katsanos CS, Madura JA 2nd, Roust LR. Essential amino acid ingestion as an efficient nutritional strategy for the preservation of muscle mass following gastric bypass surgery. Nutrition. 2016 Jan;32(1):9-13. doi: 10.1016/j.nut.2015.07.005. Epub 2015 Aug 5.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (估计的)
2026年7月1日
初级完成 (估计的)
2027年1月1日
研究完成 (估计的)
2027年2月1日
研究注册日期
首次提交
2026年5月20日
首先提交符合 QC 标准的
2026年6月2日
首次发布 (实际的)
2026年6月9日
研究记录更新
最后更新发布 (实际的)
2026年6月9日
上次提交的符合 QC 标准的更新
2026年6月2日
最后验证
2026年6月1日
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- BCKLY-YDB-2026
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
不
IPD 计划说明
Individual participant data will not be shared due to patient privacy and confidentiality concerns in accordance with Turkish Personal Data Protection Law (KVKK).
Aggregate study results will be made available through peer-reviewed publication.
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.