Eating Behavior, Nutritional Status and Appetite Hormones After Bariatric Surgery (BCKYL-YDB)
2 de junho de 2026 atualizado por: Özlem ÖZPAK AKKUŞ
Evaluation of Changes in Postoperative Eating Behavior Attitudes, Nutritional Status, and Some Hormonal Parameters Regulating Appetite in Surgical Weight Management
This study aims to evaluate changes in eating behavior attitudes, nutritional status, and appetite-regulating hormonal parameters in individuals who have undergone Laparoscopic Sleeve Gastrectomy (LSG).
The study will be conducted at Bursa Yıldırım Doruk Hospital, Department of General Surgery.
A total of 40 volunteer participants who underwent LSG within the last month will be included.
Participants will be assessed at baseline (shortly after surgery) and at 6-month follow-up.
Assessments will include anthropometric measurements (body weight, height, waist and hip circumference, BMI, waist-to-hip ratio), 3-day dietary intake records analyzed using BeBIS 8.2 software, and the Adult Eating Behavior Scale.
Biochemical parameters including fasting blood glucose, total cholesterol, triglycerides, HDL, LDL, VLDL cholesterol, and insulin will be obtained from patient files and analyzed using Advia Chemistry 2400 and Advia XPT devices.
Additionally, appetite-regulating hormones (ghrelin, GLP-1, PYY) will be analyzed from residual blood samples using the ELISA method with RelAssay Diagnostics kits by Teknogen Bioengineering Laboratory.
All data will be compared between baseline and 6-month follow-up to evaluate the impact of bariatric surgery on nutritional and hormonal outcomes.
Visão geral do estudo
Status
Ainda não está recrutando
Condições
Intervenção / Tratamento
Descrição detalhada
This observational study will be conducted at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, under the supervision of Assoc. Prof. Dogukan Durak. Forty volunteer participants who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month and meet the inclusion and exclusion criteria will be enrolled after signing an informed consent form.
Assessments will be performed at two time points: at baseline (shortly after surgery) and at 6-month follow-up.
Anthropometric Measurements: Body weight, height, waist and hip circumference will be measured. BMI and waist-to-hip ratio will be calculated accordingly. Waist circumference will be evaluated according to WHO criteria.
Dietary Assessment: A 3-day dietary intake record will be collected from each participant at both time points. Food portion sizes will be estimated using the "Food and Nutrient Photo Catalog." Energy and macronutrient intake will be analyzed using BeBIS 8.2 software and evaluated according to the Turkish Dietary Guidelines 2022 (TUBER 2022).
Eating Behavior Assessment: The Adult Eating Behavior Scale (developed by Celik et al.) will be administered at both time points. The scale consists of 18 items and 5 subscales, scored between 0-100. Higher scores indicate more positive attitudes toward eating behavior.
Biochemical and Hormonal Parameters: After 12-hour fasting, the following biochemical parameters will be obtained from patient files: fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, and insulin. Routine biochemical parameters and lipid profile will be analyzed spectrophotometrically using the Advia Chemistry 2400 device, while insulin will be measured by chemiluminescence using the Advia XPT device. Additionally, appetite-regulating hormones including ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) will be analyzed from residual blood samples stored at -20°C by Teknogen Bioengineering Laboratory using the ELISA method with an automated microplate reader (Biotek TS800) and RelAssay Diagnostics commercial kits (Ankara, Turkey).
All data will be compared between baseline and 6-month follow-up using appropriate statistical methods.
Tipo de estudo
Observacional
Inscrição (Estimado)
40
Contactos e Locais
Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.
Contato de estudo
- Nome: Özlem ÖZPAK AKKUŞ, Assoc. Prof.
- Número de telefone: +903246253300
- E-mail: dytozlemozpak@hotmail.com
Estude backup de contato
- Nome: Doğukan DURAK, Assoc. Prof.
- Número de telefone: +905327243733
- E-mail: dogukandurak404@hotmail.com
Locais de estudo
-
-
Bursa
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Bursa, Bursa, Turquia (Türkiye), 16130
- Bursa Yıldırım Doruk Hastanesi, General Surgery Clinic
-
Contato:
- Özlem ÖZPAK AKKUŞ, Assoc. Prof.
- Número de telefone: +903246253300
- E-mail: dytozlemozpak@hotmail.com
-
Contato:
- Doğukan DURAK, Assoc. Prof.
- Número de telefone: +905327243733
- E-mail: dogukandurak404@hotmail.com
-
Investigador principal:
- Özlem ÖZPAK AKKUŞ, Assoc. Prof.
-
Subinvestigador:
- Doğukan Durak, Assoc. Prof.
-
Subinvestigador:
- Seher ŞEN, Asst. Prof.
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Subinvestigador:
- Tuğçe Nur DOĞANAY YILDIRIM, MSc, RD
-
-
Critérios de participação
Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.
Critérios de elegibilidade
Idades elegíveis para estudo
- Adulto
Aceita Voluntários Saudáveis
Não
Método de amostragem
Amostra Não Probabilística
População do estudo
Adult patients who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, under the supervision of Assoc.
Prof. Dogukan Durak, and who meet the inclusion and exclusion criteria.
Descrição
Inclusion Criteria:
- Having undergone Laparoscopic Sleeve Gastrectomy (LSG) within the last month
- Aged between 18-50 years
- Signing the informed consent form
- Having a Body Mass Index (BMI) of 40 kg/m2 or between 35-40 kg/m2 with obesity-related comorbidities
- No diagnosis of depression
- No eating behavior disorder
- No psychiatric disorder
Exclusion Criteria:
- Not having undergone Laparoscopic Sleeve Gastrectomy (LSG) or not planning to undergo bariatric surgery
- Not being in the age range of 18-50 years
- Not signing the informed consent form
- Having a Body Mass Index (BMI) greater than 40 kg/m2 or less than 35 kg/m2 without obesity-related comorbidities
- Having a diagnosis of depression
- Having an eating behavior disorder
- Having a psychiatric disorder
Plano de estudo
Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.
Como o estudo é projetado?
Detalhes do projeto
Coortes e Intervenções
Grupo / Coorte |
Intervenção / Tratamento |
|---|---|
|
LSG Patients
Individuals who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, and meet the inclusion and exclusion criteria.
Participants will be assessed at baseline (shortly after surgery) and at 6-month follow-up.
|
Anthropometric measurements (body weight, height, waist and hip circumference, BMI, waist-to-hip ratio), 3-day dietary intake records, Adult Eating Behavior Scale, and biochemical and hormonal parameters (fasting blood glucose, lipid profile, insulin, ghrelin, GLP-1, PYY) will be assessed at baseline and at 6-month follow-up.
Outros nomes:
|
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Change in Serum Ghrelin Concentration (pg/mL)
Prazo: Baseline and 6 months after surgery
|
Change in serum ghrelin levels between baseline and 6-month follow-up, assessed by ELISA method.
|
Baseline and 6 months after surgery
|
|
Change in Serum GLP-1 Concentration (pmol/L)
Prazo: Baseline and 6 months after surgery
|
Change in serum glucagon-like peptide-1 (GLP-1) levels between baseline and 6-month follow-up, assessed by ELISA method.
|
Baseline and 6 months after surgery
|
|
Change in Serum PYY Concentration (pg/mL)
Prazo: Baseline and 6 months after surgery
|
Change in serum peptide YY (PYY) levels between baseline and 6-month follow-up, assessed by ELISA method.
|
Baseline and 6 months after surgery
|
|
Change in Adult Eating Behavior Scale Total Score (0-100)
Prazo: Baseline and 6 months after surgery
|
Change in Adult Eating Behavior Scale total score between baseline and 6-month follow-up.
Scale is scored between 0-100; higher scores indicate more positive eating behavior attitudes.
|
Baseline and 6 months after surgery
|
|
Change in Daily Energy Intake (kcal/day)
Prazo: Baseline and 6 months after surgery
|
Change in daily energy intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.
|
Baseline and 6 months after surgery
|
|
Change in Daily Protein Intake (g/day)
Prazo: Baseline and 6 months after surgery
|
Change in daily protein intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022
|
Baseline and 6 months after surgery
|
|
Change in Daily Carbohydrate Intake (g/day)
Prazo: Baseline and 6 months after surgery
|
Change in daily carbohydrate intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.
|
Baseline and 6 months after surgery
|
|
Change in Daily Fat Intake (g/day)
Prazo: Baseline and 6 months after surgery
|
Change in daily fat intake assessed by 3-day dietary intake records at baseline and 6-month follow-up.
Food portions will be estimated using the Food and Nutrient Photo Catalog.
Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.
|
Baseline and 6 months after surgery
|
Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
|
Change in Body Weight (kg)
Prazo: Baseline and 6 months after surgery
|
Change in body weight between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Body Mass Index (kg/m²)
Prazo: Baseline and 6 months after surgery
|
Change in BMI between baseline and 6-month follow-up.
Weight and height will be combined to report BMI in kg/m².
|
Baseline and 6 months after surgery
|
|
Change in Waist Circumference (cm)
Prazo: Baseline and 6 months after surgery
|
Change in waist circumference between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Hip Circumference (cm)
Prazo: Baseline and 6 months after surgery
|
Change in hip circumference between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Waist-to-Hip Ratio
Prazo: Baseline and 6 months after surgery
|
Change in waist-to-hip ratio between baseline and 6-month follow-up.
Waist and hip circumference measurements will be combined to calculate the waist-to-hip ratio.
|
Baseline and 6 months after surgery
|
|
Change in Fasting Blood Glucose Concentration (mg/dL)
Prazo: Baseline and 6 months after surgery
|
Change in fasting blood glucose levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Total Cholesterol Concentration (mg/dL)
Prazo: Baseline and 6 months after surgery
|
Change in total cholesterol levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Triglyceride Concentration (mg/dL)
Prazo: Baseline and 6 months after surgery
|
Change in triglyceride levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in HDL Cholesterol Concentration (mg/dL)
Prazo: Baseline and 6 months after surgery
|
Change in high-density lipoprotein (HDL) cholesterol levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in LDL Cholesterol Concentration (mg/dL)
Prazo: Baseline and 6 months after surgery
|
Change in low-density lipoprotein (LDL) cholesterol levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in VLDL Cholesterol Concentration (mg/dL)
Prazo: Baseline and 6 months after surgery
|
Change in very low-density lipoprotein (VLDL) cholesterol levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
|
Change in Fasting Insulin Concentration (µIU/mL)
Prazo: Baseline and 6 months after surgery
|
Change in fasting insulin levels between baseline and 6-month follow-up.
|
Baseline and 6 months after surgery
|
Colaboradores e Investigadores
É aqui que você encontrará pessoas e organizações envolvidas com este estudo.
Patrocinador
Investigadores
- Investigador principal: Özlem ÖZPAK AKKUŞ, Assoc. Prof., Toros University
Publicações e links úteis
A pessoa responsável por inserir informações sobre o estudo fornece voluntariamente essas publicações. Estes podem ser sobre qualquer coisa relacionada ao estudo.
Publicações Gerais
- Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995;854:1-452.
- Sherf Dagan S, Goldenshluger A, Globus I, Schweiger C, Kessler Y, Kowen Sandbank G, Ben-Porat T, Sinai T. Nutritional Recommendations for Adult Bariatric Surgery Patients: Clinical Practice. Adv Nutr. 2017 Mar 15;8(2):382-394. doi: 10.3945/an.116.014258. Print 2017 Mar.
- Celik E, Karabulut E, Bilgic P. Bariatrik Cerrahi Hastalarinda Beslenme ve Davranis Tutumu Olcegi. Bes Diy Derg. 2017;45(2):107-15.
- Pekcan G, Sanlier N, Bas M, Acar Tek N, Gokmen Ozel H. Turkiye Beslenme Rehberi (TUBER) 2022. Ankara: Hazar Reklamcilik; 2022.
- Beslenme Bilgi Sistemleri Paket Programi (BeBIS 8.2). Istanbul: Software NDB; 2015.
- Merdol TK. Toplu Beslenme Yapilan Kurumlar icin Standard Yemek Tarifleri. Hatipoglu Yayinlari; 2003.
- Rakicioglu N, Tek NA, Ayaz A, Pekcan G. Yemek ve Besin Fotograf Katalogu Olcu ve Miktarlar. Nadir Kitap; 2012.
- Pekcan G. Beslenme Durumunun Saptanmasi. Diyet El Kitabi. Ankara: Hatipoglu Yayinevi; 2013:67-142.
- Baltaci G. Obezite ve egzersiz. Saglik Bakanligi Yayinlari, Ankara; 2008.
- World Health Organization. Prevention and management of the global epidemic of obesity. Report of the WHO Consultation on Obesity. Geneva: WHO; 1997.
- Rigamonti AE, Bini S, Rocco MC, Giardini V, Massimini D, Crippa MG, Saluzzi A, Casati M, Marazzi N, Perotti M, Cimino V, Grassi G, Sartorio A, Pincelli AI. Post-prandial anorexigenic gut peptide, appetite and glucometabolic responses at different eating rates in obese patients undergoing laparoscopic sleeve gastrectomy. Endocrine. 2017 Jan;55(1):113-123. doi: 10.1007/s12020-016-0933-6. Epub 2016 Mar 29.
- Devlin MJ, Goldfein JA, Flancbaum L, Bessler M, Eisenstadt R. Surgical management of obese patients with eating disorders: a survey of current practice. Obes Surg. 2004 Oct;14(9):1252-7. doi: 10.1381/0960892042386940.
- Brown W, Dixon JB, Brien PO. Management of obesity--the role of surgery. Aust Fam Physician. 2006 Aug;35(8):584-6.
- Katsanos CS, Madura JA 2nd, Roust LR. Essential amino acid ingestion as an efficient nutritional strategy for the preservation of muscle mass following gastric bypass surgery. Nutrition. 2016 Jan;32(1):9-13. doi: 10.1016/j.nut.2015.07.005. Epub 2015 Aug 5.
Datas de registro do estudo
Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.
Datas Principais do Estudo
Início do estudo (Estimado)
1 de julho de 2026
Conclusão Primária (Estimado)
1 de janeiro de 2027
Conclusão do estudo (Estimado)
1 de fevereiro de 2027
Datas de inscrição no estudo
Enviado pela primeira vez
20 de maio de 2026
Enviado pela primeira vez que atendeu aos critérios de CQ
2 de junho de 2026
Primeira postagem (Real)
9 de junho de 2026
Atualizações de registro de estudo
Última Atualização Postada (Real)
9 de junho de 2026
Última atualização enviada que atendeu aos critérios de controle de qualidade
2 de junho de 2026
Última verificação
1 de junho de 2026
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
- Distúrbios Nutricionais
- Supernutrição
- Peso corporal
- Alterações de Peso Corporal
- Excesso de peso
- Condições Patológicas, Sinais e Sintomas
- Comportamento
- Doenças Nutricionais e Metabólicas
- Sinais e sintomas
- Comportamento, animal
- Obesidade
- Perda de peso
- Comportamento Alimentar
- Qualidade, acesso e avaliação da assistência médica
- Técnicas de investigação
- Métodos epidemiológicos
- Coleta de dados
- Mecanismos de avaliação de saúde
- Qualidade de assistência médica
- Saúde pública
- Meio ambiente e saúde pública
- Medições epidemiológicas
- Avaliação nutricional
Outros números de identificação do estudo
- BCKLY-YDB-2026
Plano para dados de participantes individuais (IPD)
Planeja compartilhar dados de participantes individuais (IPD)?
NÃO
Descrição do plano IPD
Individual participant data will not be shared due to patient privacy and confidentiality concerns in accordance with Turkish Personal Data Protection Law (KVKK).
Aggregate study results will be made available through peer-reviewed publication.
Informações sobre medicamentos e dispositivos, documentos de estudo
Estuda um medicamento regulamentado pela FDA dos EUA
Não
Estuda um produto de dispositivo regulamentado pela FDA dos EUA
Não
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .