Human Absorption Study of Liposomal Glucosamine Supplements
Effect of Double Nutri® Liposomal Encapsulation Technology on Human Absorption of Glucosamine Supplements
The objective of this study is to evaluate the effects of liposomal encapsulation using different ratios of gum arabic and lecithin on the bioavailability of a liquid glucosamine supplement in humans.
연구 개요
상태
상세 설명
This study is a single-center, self-controlled crossover human trial designed to evaluate the differences in blood concentration changes and bioavailability following a single oral dose of glucosamine supplements.
Healthy adult participants aged 18 years and older will be enrolled. Each participant will complete four study sessions, with a minimum washout period of 7 days between sessions. On each study day, venous blood samples will be collected prior to test product administration (0 minutes) to assess glucosamine levels, complete blood count, blood lipids, blood glucose, and liver and kidney function indicators.
After baseline blood collection, a standardized breakfast will be provided and consumed within 10 minutes, followed by administration of the test product. Venous blood samples will then be collected at 0.5, 1, 2, 4, 8, and 24 hours post-intake to measure glucosamine concentrations. Lunch will be provided after the 4-hour blood draw, and dinner will be provided after the 8-hour blood draw. Identical meals will be provided on four study sessions.
연구 유형
등록 (추정된)
단계
- 해당 없음
연락처 및 위치
연구 연락처
- 이름: Tong-Lin Wu
- 전화번호: +886 02-87977811
- 이메일: Tony.Wu@tci-bio.com
연구 연락처 백업
- 이름: Ping Lin
- 전화번호: +886 02-87977811
- 이메일: candice.lin@tci-bio.com
연구 장소
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Taipei, 대만, 114
- 모병
- TCI Co., Ltd
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연락하다:
- Ping Lin
- 전화번호: +886 02-8797-7811
- 이메일: candice.lin@tci-bio.com
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Adults aged ≥18 years, regardless of sex, who are willing to sign the informed consent form and are able to fully comply with all study procedures.
Exclusion Criteria:
- Pregnant or breastfeeding women, or individuals who are unwilling to use a physical method of contraception during the study period, such as condoms or an intrauterine device.
- Employees of TCI Co., Ltd. and their family members.
- Individuals who have regularly taken any supplements or medications containing glucosamine or N-acetylglucosamine (N-acetyl-glucosamine) within 14 days prior to study initiation, defined as use for ≥7 consecutive days.
- Individuals with a history of chronic gastrointestinal disorders, including irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), chronic diarrhea, Crohn's disease, celiac disease, bowel control problems/fecal incontinence, pancreatitis, peptic ulcer disease, colorectal cancer, short bowel syndrome, or ulcerative colitis; a history of epilepsy or seizures; liver or kidney disease; malignancy; endocrine disorders; psychiatric disorders; alcohol or substance abuse; or other significant organic diseases, as determined based on medical history.
- Individuals with a history of gastrointestinal surgery, organ transplantation, or other major surgery.
- Individuals who have experienced acute gastroenteritis within 2 weeks prior to study initiation.
- Individuals with a history of allergy to any ingredient in the investigational products. The investigational products contain shrimp- and soy-derived ingredients.
- Vegetarians, as the glucosamine used in this study is derived from shrimp.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 더블
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
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실험적: High-Emulsified Liposomal Glucosamine Liquid
One sachet will be administered per dose, with each sachet containing 1,500 mg of glucosamine. |
The formulation primarily consists of glucosamine HCl, a high proportion of soy lecithin, and gum arabic, and is processed using the patented Double Nutri Liposomal technology.
다른 이름들:
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실험적: Low-Emulsified Liposomal Glucosamine Liquid
One sachet will be administered per dose, with each sachet containing 1,500 mg of glucosamine. |
The formulation primarily consists of glucosamine HCl, a low proportion of soy lecithin, and gum arabic, and is processed using the patented Double Nutri Liposomal technology.
다른 이름들:
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활성 비교기: Glucosamine Liquid without Liposomal
One sachet will be administered per dose, with each sachet containing 1,500 mg of glucosamine. |
The formulation primarily consists of glucosamine HCl and is not processed using the patented Double Nutri Liposomal technology. |
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활성 비교기: Glucosamine tablet without Liposomal
Three tablets will be administered per dose, with each tablet containing 500 mg of glucosamine. |
The tablet formulation primarily consists of glucosamine HCl and is not processed using liposomal technology. |
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Plasma glucosamine level (ng/mL)
기간: at 24 hours after taking test sample
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Plasma glucosamine levels will be measured at fasting and at 0.5, 1, 2, 4, 8, and 24 hours post-intake. |
at 24 hours after taking test sample
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공동 작업자 및 조사자
스폰서
수사관
- 수석 연구원: Tong-Lin Wu, TCI Co., Ltd.
연구 기록 날짜
연구 주요 날짜
연구 시작 (추정된)
기본 완료 (추정된)
연구 완료 (추정된)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .