A Research Study to Investigate How Well the Medicine CagriSema Lowers High Blood Pressure in People Living With High Blood Pressure and Obesity (REDEFINE)
2026년 10월 30일 업데이트: Novo Nordisk A/S
Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema) in Participants With Hypertension and Obesity
This study is testing whether CagriSema is safe and works well in adults with high blood pressure and excess body weight. Participants will receive CagriSema, semaglutide, cagrilintide, or placebo, and treatment will be assigned by chance. CagriSema and cagrilintide are investigational medicines, while semaglutide is already available by prescription.
연구 개요
연구 유형
중재적
등록 (추정된)
1408
단계
- 3단계
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 연락처
- 이름: Novo Nordisk
- 전화번호: (+1) 866-867-7178
- 이메일: clinicaltrials@novonordisk.com
연구 장소
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Gauteng
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Johannesburg, Gauteng, 남아프리카, 2013
- Wits Bara Clinical Trial Site
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Johannesburg, Gauteng, 남아프리카, 1818
- Soweto Clinical Trial Centre
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Midrand, Gauteng, 남아프리카, 1685
- Dr A Jacovides and Partners Inc
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KwaZulu-Natal
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Durban, KwaZulu-Natal, 남아프리카, 4091
- Dr Vawda's site
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eMkhomazi, KwaZulu-Natal, 남아프리카, 4170
- Dr T Padayachee
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Lenasia
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Gauteng, Lenasia, 남아프리카, 1827
- Dr Moosa's Rooms
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Deventer, 네덜란드, 7416 SE
- Deventer Ziekenhuis - Interne geneeskunde
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Dordrecht, 네덜란드, 3318 AT
- Albert Schweitzer Zkh, Dordwijk - Nefrologie
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Eindhoven, 네덜란드, 5623 EJ
- Catharina Zkh Eindhoven - Interne geneeskunde
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Haarlem, 네덜란드, 2035 RC
- Spaarne Gasthuis Haarlem - Interne
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Heerlen, 네덜란드, 6419 PC
- Zuyderland ziekenhuis - Interne
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Hoogeveen, 네덜란드, 7909 AA
- Bethesda Diabetes Research Center
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Nijmegen, 네덜란드, 6525 GA
- RadboudUMC - Vasculaire geneeskunde
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Utrecht, 네덜란드, 3584 CX
- UMC Utrecht - Vasculaire geneeskunde
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Busan, 대한민국, 49201
- Dong-A University Hospital_Family Medicine
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Daegu, 대한민국, 41944
- Kyungpook National University Hospital_Family Medicine
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Daegu, 대한민국, 42601
- Keimyung University Dongsan Hospital_Endocrinology
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Daejeon, 대한민국, 35365
- Konyang University Hospital_Family Medicine
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Seoul, 대한민국, 03722
- Severance Hospital, Yonsei University Health System_Family Medicine
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Seoul, 대한민국, 04763
- Hanyang University Seoul Hospital_Family Medicine
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Gyeonggi-do
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Anyang-si, Gyeonggi-do, 대한민국, 14068
- Hallym University Sacred Heart Hospital_Family Medicine
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Bucheon-si, Gyeonggi-do, 대한민국, 14647
- The Catholic University of Korea, Bucheon ST. Mary's Hospital_Endocrinology
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Seongnam-si, Gyeonggi-do, 대한민국, 13620
- Seoul National University Bundang Hospital_Family Medicine
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Gyeongsangnam-do
-
Yangsan, Gyeongsangnam-do, 대한민국, 50612
- Pusan National University Yangsan Hospital_Family Medicine
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-
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Herning, 덴마크, 7400
- Regionshospitalet Gødstrup - Universitetsklinikken for Nyresygdomme og Blodtryksforhøjelse
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Holbæk, 덴마크, 4300
- Holbæk Sygehus - Forskningsenheden, Medicinsk Afdeling, afs. 44-4
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Hvidovre, 덴마크, 2650
- Hvidovre Hospital Endokrinologisk forsknings afsnit 159
-
Viborg, 덴마크, 8800
- Viborg Sygehus
-
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Region Syddanmark
-
Esbjerg, Region Syddanmark, 덴마크, 6700
- Sydvestjysk Sygehus Esbjerg - Medicinsk Endokrinologisk Ambulatorium, Forskningsenheden
-
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-
-
-
Berlin, 독일, 13405
- KARDIA - Dr. Hashemi
-
Duisburg, 독일, 47269
- MVZ Hausärzte Großenbaum GmbH Duisburg
-
Elsterwerda, 독일, 04910
- Zentrum für klinische Studien Südbrandenburg GmbH
-
Frankfurt, 독일, 60590
- Uniklinik FFM - Nephrologie
-
Hamburg, 독일, 22607
- Wendisch - Dahl Hamburg - DZHW
-
Münster, 독일, 48145
- Institut für Diabetesforschung GmbH Münster - Dr. med. Rose
-
Oldenburg in Holstein, 독일, 23758
- RED-Institut für medizinische Forschung und Fortbildung GmbH
-
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-
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California
-
Concord, California, 미국, 94520
- John Muir Physicians Network
-
Costa Mesa, California, 미국, 92627
- Aurora FDRC Inc.
-
Fullerton, California, 미국, 92835
- Providence Medical Foundation
-
Montclair, California, 미국, 91763
- Catalina Research Institute, LLC
-
Palm Springs, California, 미국, 92262
- Desert Oasis Hlthcr Med Group
-
San Dimas, California, 미국, 91773
- N America Res Inst - San Dimas
-
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Connecticut
-
Waterbury, Connecticut, 미국, 06708
- Chase Medical Research LLC
-
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Florida
-
Clearwater, Florida, 미국, 33765
- Clinical Res Of W Florida Inc
-
Ocala, Florida, 미국, 34470
- Renstar Medical Research
-
Orlando, Florida, 미국, 32825
- Florida Institute for Clinical research
-
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Georgia
-
Albany, Georgia, 미국, 31707
- Javara Inc. / Privia Medical Group Georgia LLC
-
Conyers, Georgia, 미국, 30094
- Hope Clin Res & Wellness
-
Roswell, Georgia, 미국, 30076
- Endocrine Research Solutions, Inc
-
Savannah, Georgia, 미국, 31406
- Javara Inc. / Privia Medical Group Georgia LLC
-
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Illinois
-
Chicago, Illinois, 미국, 60640
- Great Lakes Clinical Trials
-
Morton, Illinois, 미국, 61550
- Koch Research
-
Skokie, Illinois, 미국, 60077
- Evanston Premier Hlthcr Res
-
Skokie, Illinois, 미국, 60077
- Endeavor Health
-
Springfield, Illinois, 미국, 62702
- SIU Medicine
-
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Indiana
-
Indianapolis, Indiana, 미국, 46260
- Midwest Inst For Clin Res
-
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Iowa
-
West Des Moines, Iowa, 미국, 50266
- Iowa Diabetes Research
-
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Kentucky
-
Bowling Green, Kentucky, 미국, 42101
- Graves Gibert Clinic
-
Louisville, Kentucky, 미국, 40213
- Monroe Biomedical Research, LLC
-
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Michigan
-
Buckley, Michigan, 미국, 49620
- Northern Pines Hlth Ctr, PC
-
Flint, Michigan, 미국, 48504
- Aa Mrc Llc
-
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Missouri
-
City of Saint Peters, Missouri, 미국, 63303
- StudyMetrix Research LLC
-
St Louis, Missouri, 미국, 63128
- Amicis Centers of Clinical Research
-
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New Hampshire
-
Portsmouth, New Hampshire, 미국, 03801
- Seacoast Kidney & Htn Specialists
-
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New York
-
West Seneca, New York, 미국, 14224
- Southgate Medical Group, LLP
-
Westfield, New York, 미국, 14787
- Great Lakes Medical Research
-
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North Carolina
-
Raleigh, North Carolina, 미국, 27609
- Medication Management, LLC
-
Raleigh, North Carolina, 미국, 27609
- Accellacare_NC
-
Statesville, North Carolina, 미국, 28625
- Piedmont Healthcare, Inc.
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Ohio
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Canton, Ohio, 미국, 44718
- Diab & Endo Assoc of Stark Co
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Wadsworth, Ohio, 미국, 44281-9236
- Family Practice Center of Wadsworth Inc.
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Oklahoma
-
Norman, Oklahoma, 미국, 73072
- Lynn Institute of Norman
-
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Rhode Island
-
Cumberland, Rhode Island, 미국, 02864
- Clinical Res Collaborative
-
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South Carolina
-
North Charleston, South Carolina, 미국, 29405
- Coastal Carolina Res Ctr
-
Spartanburg, South Carolina, 미국, 29303
- Spartanburg Medical Research
-
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Tennessee
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Bristol, Tennessee, 미국, 37620
- Holston Medical Group Pc
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Kingsport, Tennessee, 미국, 37660
- Holston Medical Group
-
Nashville, Tennessee, 미국, 37203
- Clinical Research Associates
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Texas
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Amarillo, Texas, 미국, 79124
- Amarillo Med Spec LLP
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Austin, Texas, 미국, 78731
- Texas Diabetes & Endocrinology
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Austin, Texas, 미국, 78749
- Texas Diabetes & Endocrinology, P.A._Austin
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Bellaire, Texas, 미국, 77401
- Juno Research, LLC
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Dallas, Texas, 미국, 75231
- North Texas Endocrine Center
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Dallas, Texas, 미국, 75226
- Baylor Jack and Jane Hamilton
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Dallas, Texas, 미국, 75230
- Velocity Clin Res, Dallas
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Houston, Texas, 미국, 77079
- The Endocrine Center
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Houston, Texas, 미국, 77036
- Discovery MM Services Inc
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Lampasas, Texas, 미국, 76550
- Radiance Clinical Research
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Longview, Texas, 미국, 75605
- DCOL Ctr for Clin Res
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San Antonio, Texas, 미국, 78212
- Clinical Advancement Center
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San Antonio, Texas, 미국, 78233
- Northeast Clinical Research of San Antonio
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Shavano Park, Texas, 미국, 78231
- Consano Clinical Research, LLC
-
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Washington
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Renton, Washington, 미국, 98057
- Rainier Clin Res Ctr Inc
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Alken, 벨기에, 3570
- Anima Research Center
-
Bonheiden, 벨기에, 2820
- Imelda
-
Genk, 벨기에, 3600
- Ziekenhuis Oost-Limburg
-
Ghent, 벨기에, 9000
- Universitair Ziekenhuis Gent
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Leuven, 벨기에, 3000
- Uz Leuven
-
Mons, 벨기에, 7000
- CHU Helora - Hôpital de Mons - Site Constantinople
-
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-
-
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Burgas, 불가리아, 8000
- Medical center Medconsult Burgas OOD
-
Panagyurishte, 불가리아, 4500
- MHAT - Uni Hospital OOD, Clinic of Cardiology
-
Pernik, 불가리아, 2308
- MHAT Rahila Angelova AD, Research Center
-
Plovdiv, 불가리아, 4002
- Dr. Ilcho Ilchev - AIPSMC - Cardiology EOOD
-
Shumen, 불가리아, 9700
- MHAT Shumen AD
-
Sliven, 불가리아, 8800
- GPSMC - Inacor OOD
-
Sofia, 불가리아, 1202
- DCC Ascendent OOD
-
Sofia, 불가리아, 1231
- MC Dr. Atanasov EOOD
-
Sofia, 불가리아, 1510
- MC Hera EOOD - Sofia
-
Sofia, 불가리아, 1431
- UMHAT Aleksandrovska EAD, Clinic of Cardiology
-
Sofia, 불가리아, 1750
- MHAT Sveta Anna Sofia AD, Clinic of Cardiology
-
Sofia, 불가리아, 1527
- UMHAT Tsaritsa Yoanna - ISUL EAD, Cardiology
-
Sofia, 불가리아, 1612
- Nevrovita - Medical Center OOD
-
Varna, 불가리아, 9010
- UMHAT Sveta Marina EAD, Clinic of Internal Diseases
-
Varna, 불가리아, 9009
- SHATC - Cardiolife OOD - Varna
-
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Minas Gerais
-
Belo Horizonte, Minas Gerais, 브라질, 30455-610
- Centro Universitário de Belo Horizonte (UNIBH)
-
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Paraná
-
Curitiba, Paraná, 브라질, 80230-130
- PUCPR - Pontificia Universidade Catolica do Parana
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São Paulo
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Bragança Paulista, São Paulo, 브라질, 12916-542
- Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista
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Campinas, São Paulo, 브라질, 13092-133
- i9 Pesquisas Clínicas
-
Campinas, São Paulo, 브라질, 13060-803
- PUCCAMP - Hospital e Maternidade Celso Pierro
-
Campinas, São Paulo, 브라질, 13083-887
- Centro de Pesquisa Clínica da Faculdade de Ciências Médicas - Unicamp
-
São Paulo, São Paulo, 브라질, 05403-000
- Instituto do Coração - HCFMUSP
-
São Paulo, São Paulo, 브라질, 04038-032
- IBTED Tecnologia e Educação em Diabetes - EPP
-
São Paulo, São Paulo, 브라질, 01228-000
- CPQuali Pesquisa Clínica Ltda
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Badajoz, 스페인, 06080
- Hospital Universitario de Badajoz
-
Barcelona, 스페인, 08022
- Centro Médico Quirón-Teknon
-
Barcelona, 스페인, 08036
- Clinic Barcelona_Endocrinología
-
León, 스페인, 24008
- H. de León_Endocrinología
-
Madrid, 스페인, 28016
- Hospital Universitario Sanitas Virgen del Mar
-
Madrid, 스페인, 28009
- H.G.Marañón_Endocrino-Obesidad
-
Santander, 스페인, 39008
- H. Univ. Marqués de Valdecilla_Endocrinología
-
Santiago de Compostela, 스페인, 15702
- Clínica Gaias Santiago
-
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-
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Buenos Aires, 아르헨티나, C1425AGC
- Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
-
CABA, 아르헨티나, C1060ABA
- CEDIC Centro de Investigación Clínica
-
CABA, 아르헨티나, C1120AAC
- Centro Médico Viamonte SRL
-
Rosario, 아르헨티나, S2000PBJ
- CAICI
-
Santiago del Estero, 아르헨티나, G4200
- Sanatorio Norte
-
-
Buenos Aires
-
CABA, Buenos Aires, 아르헨티나, C1128 AAF
- Mautalen Salud e investigación
-
CABA, Buenos Aires, 아르헨티나, C1440CFD
- CEMEDIC
-
Capital Federal, Buenos Aires, 아르헨티나, C1056ABI
- Centro de Investigaciones Metabólicas
-
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La Pampa Province
-
Santa Rosa, La Pampa Province, 아르헨티나, 6300
- Fundación CESIM
-
-
Mendoza Province
-
Godoy Cruz, Mendoza, Mendoza Province, 아르헨티나, 5501
- Hospital Español de Mendoza
-
-
-
-
-
Bristol, 영국, BS37 4AX
- West Walk Surgery
-
Cambridge, 영국, CB2 0QQ
- Addenbrooke's Hospital_Cambridge
-
Chippenham, 영국, SN14 6GT
- Hathaway Medical Centre
-
Harrow, 영국, HA3 7LT
- Belmont Health Centre
-
Hounslow, 영국, TW4 7NJ
- HMC Health - Heston - The Meadows Centre for Health
-
London, 영국, EC1M 6BQ
- William Harvey Research Institute
-
London, 영국, SW1P 2PF
- Healthcare Central London - South Westminster Centre for Health
-
-
Cambridgeshire
-
Wisbech, Cambridgeshire, 영국, PE13 3UZ
- Trinity Surgery
-
-
Cornwall
-
Newquay, Cornwall, 영국, TR7 1RU
- Newquay Health Centre
-
-
Hertfordshire
-
Bushey, Hertfordshire, 영국, WD23 2NN
- Attenborough Surgery
-
-
-
-
Apulia
-
Bari, Apulia, 이탈리아, 70124
- AUO Consorziale Policlinico Bari - UOC Medicina Interna Universitaria (Cesare Frugoni)
-
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Calabria
-
Catanzaro, Calabria, 이탈리아, 88100
- AOU Renato Dulbecco - Unità Operativa Complessa Medicina Interna
-
-
Emilia-Romagna
-
Ferrara, Emilia-Romagna, 이탈리아, 44124
- Arcispedale Sant'Anna (Cona) - Medicina Interna Universitaria
-
-
Lazio
-
Rome, Lazio, 이탈리아, 00189
- Azienda Ospedaliero - Universitaria Sant'Andrea - UOC Cardiologia
-
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Lombardy
-
Brescia, Lombardy, 이탈리아, 25123
- Spedali Civili Brescia - U.O. Medicina Generale 2
-
Milan, Lombardy, 이탈리아, 20162
- Grande Ospedale Metropolitano Niguarda - Dipartimento di Cardiologia Clinica
-
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Molise
-
Pozzilli (IS), Molise, 이탈리아, 86077
- NeuroMed S.p.A. - Dipartimento di Angio-Cardio-Neurologia
-
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RM
-
Rome, RM, 이탈리아, 00168
- Fondazione Policlinico Universitario Agostino Gemelli IRCS
-
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Sicily
-
Palermo, Sicily, 이탈리아, 90127
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
-
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The Marches
-
Ancorna, The Marches, 이탈리아, 60127
- INRCA Ancona - UOC Clinica Medica e Geriatrica
-
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Tuscany
-
Siena, Tuscany, 이탈리아, 53100
- Azienda Ospedaliero Universitaria Senese - Endocrinologia
-
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Veneto
-
Padova, Veneto, 이탈리아, 35128
- Azienda Ospedaliera di Padova - UOSD Chirurgia Bariatrica
-
-
-
-
-
Arakawa-ku, Tokyo, 일본, 116-0012
- Kumanomae Nishimura Naika Clinic_Internal Medicine
-
Okayama, 일본, 700-8558
- Okayama University Hospital_Neph. and Diabetes, Metabolism
-
Sendai-shi, Miyagi, 일본, 983-0039
- Shinden Higashi Clinic_Internal medicine
-
Tokyo, 일본, 103-0027
- Tokyo-Eki Center-building Clinic_Internal Medicine
-
Tokyo, 일본, 104-0031
- Fukuwa Clinic_Internal Medicine
-
Tokyo, 일본, 160-0004
- Clinical Research Hospital Tokyo_Internal medicine
-
-
Kanagawa
-
Yamato-shi, Kanagawa, 일본, 242-0004
- Tsuruma Kaneshiro Diabetes Clinic_Internal medicine
-
-
-
-
-
Québec, 캐나다, G1V 4T3
- Diex Recherche Quebec
-
Québec, 캐나다, G1V 4G5
- IUCPQ - Universite Laval
-
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British Columbia
-
Vancouver, British Columbia, 캐나다, V6Z 2T1
- Spectrum Health Clinic
-
Victoria, British Columbia, 캐나다, V8V 4A1
- Dr. M.B. Jones Inc
-
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New Brunswick
-
Moncton, New Brunswick, 캐나다, E1G 1A7
- G.A. Research Associates Ltd.
-
-
Nova Scotia
-
Halifax, Nova Scotia, 캐나다, B3H 1V7
- Nova Scotia Health Authority
-
-
Ontario
-
Hamilton, Ontario, 캐나다, L8L 5G4
- Premier Clinical Trial Research Network (PCTRN)
-
Hamilton, Ontario, 캐나다, L8L 5G4
- Hamilton Medical Research Group
-
London, Ontario, 캐나다, N5W 6A2
- Milestone Research
-
-
Quebec
-
Trois-Rivières, Quebec, 캐나다, G9A 4P3
- Diex Recherche Trois-Rivieres
-
-
-
-
-
Elblag, 폴란드, 82-300
- Centrum Kliniczno-Badawcze J. Brzezicki, B. Górnikiewicz-Brzezicka Lekarze Spółka Partnerska
-
Gdansk, 폴란드, 80-214
- Uniwersyteckie Centrum Kliniczne
-
Gdansk, 폴란드, 80-462
- Copernicus Podmiot Leczniczy Sp. z o.o.
-
Krakow, 폴란드, 30-721
- Linden sp. z o.o. sp. k.
-
Krakow, 폴란드, 31-322
- Gyncentrum Sp. z o. o.
-
Lodz, 폴란드, 93-513
- Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika
-
Rzeszów, 폴란드, 35-205
- EMED Centrum Usług Medycznych Ewa Smialek
-
Siedlce, 폴란드, 08-110
- Lukmed 2 Sp. z o.o.
-
Starachowice, 폴란드, 27-200
- Star Badania Kliniczne Sp. z o.o
-
Warsaw, 폴란드, 04-628
- Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy
-
Świnoujście, 폴란드, 72-600
- Balticmed Świnoujście Sp. z o. o.
-
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Masovian Voivodeship
-
Grodzisk Mazowiecki, Masovian Voivodeship, 폴란드, 05-825
- Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II
-
Ostrów Mazowiecka, Masovian Voivodeship, 폴란드, 07-300
- Kresmed Sp. z o. o.
-
Warsaw, Masovian Voivodeship, 폴란드, 04-635
- Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy
-
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Pomeranian Voivodeship
-
Gdynia, Pomeranian Voivodeship, 폴란드, 81-157
- Ind. Spec. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman
-
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Ponce, 푸에르토 리코, 00716
- Ponce Med School Found Inc
-
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Budapest, 헝가리, H-1141
- Cardiogeneral Kft.
-
Budapest, 헝가리, 1046
- Újpesti Egészségközpont
-
Budapest, 헝가리, H-1021
- Budapesti Szent Ferenc Kórház
-
Békéscsaba, 헝가리, 5600
- Trial Pharma Kft.
-
Békéscsaba, 헝가리, 5600
- Békés Vármegyei Központi Kórház
-
Szeged, 헝가리, 6724
- KomplexLabor Diagnosztika Kft.
-
-
Bács-Kiskun county
-
Kalocsa, Bács-Kiskun county, 헝가리, 6300
- Stúdium Egészségház Kft.
-
-
Hajdú-Bihar
-
Debrecen, Hajdú-Bihar, 헝가리, 4032
- Debreceni Egyetem
-
-
-
-
New South Wales
-
Castle Hill, New South Wales, 호주, 2154
- Castle Hill Medical Centre
-
Darlinghurst, New South Wales, 호주, 2010
- Momentum Clinical Research Darlinghurst
-
Maroubra, New South Wales, 호주, 2035
- Australian Clinical Research Network
-
Sydney, New South Wales, 호주, 2148
- Roger Chih Yu Chen
-
-
Queensland
-
Douglas, Queensland, 호주, 4814
- Townsville University Hospital
-
-
Victoria
-
Torquay, Victoria, 호주, 3228
- Clinical Trials Institute
-
-
Western Australia
-
Bunbury, Western Australia, 호주, 6230
- Brecken Health Clinical Trials
-
Perth, Western Australia, 호주, 6000
- Dobney Hypertension Centre
-
-
참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
18년 이상 (성인, 고령자)
건강한 자원 봉사자를 받아들입니다
아니
연구 대상 성별
모두
설명
Inclusion Criteria:
- Male or female (sex at birth).
- Age 18 years or above at the time of signing the informed consent.
- Resting in-office SBP of 140-160 mmHg (both inclusive) at screening (V1-Optional/V1) and the Run-in visit. Systolic blood pressure will be calculated as the mean of the second and third consecutive readings of triplicated blood pressure readings collected at 2-minute intervals with the blood pressure monitor provided by the Sponsor.
- Body mass index greater than or equal to (>=) 30.0 kilograms per metre square (kg/m^2) at screening.
- Not receiving Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2i) or antihypertensive medication or on stable (i.e., same drug(s), dose and dosing frequency) SGLT2i or antihypertensive treatment >= 30 days prior to screening.
For participants with Type 2 Diabetes (T2D)
The following inclusion criteria apply at screening in addition to the inclusion criteria listed above:
- Diagnosed with T2D >= 90 days before screening.
- Glycated Haemoglobin (HbA1c) 6.5-10.0% (48-86 millimoles per mole (mmol/mol)) (both inclusive) as measured by the central laboratory at screening.
- Treatment with either lifestyle intervention only, or treatment with 1-3 marketed oral antidiabetic drugs (metformin, α-glucosidase inhibitors, glinides, SGLT2i or thiazolidinediones, as a single agent or in combination) according to local label.
- Treatment with antidiabetic medication should be stable (i.e., same drug(s), dose and dosing frequency) for at least 90 days before screening.
Exclusion Criteria:
- Known orthostatic hypotension or orthostatic hypotension at screening (V1-Optional/V1).
- Known secondary hypertension due to renovascular hypertension (renal artery stenosis), primary aldosteronism, Cushing's syndrome, pheochromocytoma, acromegaly, coarctation of the aorta, or any other identifiable cause of secondary hypertension.
- Currently under medical investigation for any cause of secondary hypertension.
- Hospitalisation within the last 90 days before screening for hypertension or hypertensive crisis.
- Atrial fibrillation at the Run-in visit or history of frequent intermittent or chronic atrial fibrillation.
- Moderate-to-severe anaemia with Hgb lesser than (<) 10.9 grams per decilitre (g/dL) as measured by the central lab at screening.
- A change in body weight greater than (>) 5% within 90 days before screening irrespective of medical records.
- Treatment with any medication prescribed for the indication of obesity or weight management within 90 days before screening.
- Use of any Glucagon-Like Peptide-1 Receptor Agonist (GLP-1 RA), including medication with GLP-1 RA activity, or amylin agonists, within 90 days before screening.
For participants without T2D
- HbA1c greater than or equal to >= 6.5 % (48 mmol/mol) as measured by the central laboratory at screening.
- History of type 1 or type 2 diabetes mellitus.
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 네 배로
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
|
실험적: CagriSema
Participants will receive CagriSema subcutaneously once weekly. |
CagriSema will be administered subcutaneously. |
|
활성 비교기: Semaglutide
Participants will receive semaglutide subcutaneously once weekly. |
Semaglutide will be administered subcutaneously. |
|
활성 비교기: Cagrilintide
Participants will receive cagrilintide subcutaneously once weekly. |
Cagrilintide will be administered subcutaneously. |
|
위약 비교기: Placebo
Participants will receive placebo subcutaneously once weekly. |
Placebo will be administered subcutaneously. |
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
CagriSema versus Placebo : Change in in-office systolic blood pressure (SBP)
기간: From baseline (week 0) to week 32
|
Measured in millimeters of mercury (mmHg). |
From baseline (week 0) to week 32
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
CagriSema versus Semaglutide and Cagrilintide : Change in in-office systolic blood pressure
기간: From baseline (week 0) to week 32
|
Measured in mmHg. |
From baseline (week 0) to week 32
|
|
Change in Home blood pressure monitoring (HBPM) -based systolic blood pressure
기간: From baseline (week 0) to week 32
|
Measured in mmHg. |
From baseline (week 0) to week 32
|
|
Number of participants who achieve a target goal of in-office systolic blood pressure lesser than or equal to (≤) 130 mmHg
기간: At Week 32
|
Measured as Count of participants. |
At Week 32
|
|
Number of participants who achieve American College of Cardiology and the American Heart Association (ACC/AHA) guidelines based blood pressure targets lesser than (<) 130/80 mmHg
기간: At Week 32
|
Measured as Count of participants. |
At Week 32
|
|
Change in body weight (%)
기간: From baseline (week 0) to week 32
|
Measured in percentage (%). |
From baseline (week 0) to week 32
|
|
Change in body weight (Kg)
기간: From baseline (week 0) to week 32
|
Measured in Kilograms (kg). |
From baseline (week 0) to week 32
|
|
Change in waist circumference
기간: From baseline (week 0) to week 32
|
Measured in centimetre (cm). |
From baseline (week 0) to week 32
|
|
Change in ACC/AHA 10-year atherosclerotic cardiovascular disease (ASCVD) risk score
기간: From baseline (week 0) to week 32
|
Measured in percentage of risk. ACC/AHA risk estimator calculates 10 year risk of ASCVD using a formula which includes age, sex, race, total cholesterol, high density lipoprotein (HDL) cholesterol, systolic blood pressure, blood pressure medication use, diabetes status, smoking status; minimum score 0, maximum score 100 where higher score indicates higher risk of 10-year risk of ASCVD. |
From baseline (week 0) to week 32
|
|
Ratio to baseline of lipids: Total cholesterol
기간: From baseline (week 0) to week 32
|
Measured in Ratio. |
From baseline (week 0) to week 32
|
|
Ratio to baseline of lipids: HDL cholesterol
기간: From baseline (week 0) to week 32
|
Measured in Ratio. |
From baseline (week 0) to week 32
|
|
Ratio to baseline of lipids: Low Density Lipoprotein (LDL) cholesterol
기간: From baseline (week 0) to week 32
|
Measured in Ratio. |
From baseline (week 0) to week 32
|
|
Ratio to baseline of lipids: Very Low Density Lipoprotein (VLDL) cholesterol
기간: From baseline (week 0) to week 32
|
Measured in Ratio. |
From baseline (week 0) to week 32
|
|
Ratio to baseline of lipids: Non-HDL cholesterol
기간: From baseline (week 0) to week 32
|
Measured in Ratio. |
From baseline (week 0) to week 32
|
|
Ratio to baseline of lipids: Triglycerides
기간: From baseline (week 0) to week 32
|
Measured in Ratio. |
From baseline (week 0) to week 32
|
|
Ratio to baseline of high-sensitivity C-reactive protein (hsCRP)
기간: From baseline (week 0) to week 32
|
Measured in Ratio. |
From baseline (week 0) to week 32
|
공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
스폰서
수사관
- 연구 책임자: Clinical Transparency (dept. 2834), Novo Nordisk A/S
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (추정된)
2026년 11월 11일
기본 완료 (추정된)
2028년 6월 1일
연구 완료 (추정된)
2028년 7월 13일
연구 등록 날짜
최초 제출
2026년 10월 30일
QC 기준을 충족하는 최초 제출
2026년 10월 30일
처음 게시됨 (실제)
2026년 11월 5일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
2026년 11월 5일
QC 기준을 충족하는 마지막 업데이트 제출
2026년 10월 30일
마지막으로 확인됨
2026년 10월 1일
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- NN9838-8768
- U1111-1338-1943 (기타 식별자: World Health Organization (WHO))
- 2026-526360-21 (기타 식별자: European Medical Agency (EMA))
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
예
IPD 계획 설명
According to the Novo Nordisk disclosure commitment on novonordisk-trials.com
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
예
미국 FDA 규제 기기 제품 연구
아니
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .