A 6-Month Extension Study To The B2061032 Study To Evaluate The Safety, Tolerability, And Efficacy Of DVS SR In The Treatment Of Child And Adolescent Outpatients With MDD
28 juni 2017 bijgewerkt door: Pfizer
A 6-month, Open-label, Multi-center, Flexible Dose Extension Study To The B2061032 Study To Evaluate The Safety, Tolerability And Efficacy Of Desvenlafaxine Succinate Sustained Release (Dvs Sr) Tablets In The Treatment Of Children And Adolescent Outpatients With Major Depressive Disorder
This is a 6-month, open-label, flexible-dose study evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) in the Treatment of Child and Adolescent Outpatients with Major Depressive Disorder (MDD).
Studie Overzicht
Toestand
Voltooid
Conditie
Interventie / Behandeling
Studietype
Ingrijpend
Inschrijving (Werkelijk)
283
Fase
- Fase 3
Contacten en locaties
In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.
Studie Locaties
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Region Metropolitana
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Santiago, Region Metropolitana, Chili, 7500710
- BioMedica Research Group
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Alabama
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Birmingham, Alabama, Verenigde Staten, 35294-0009
- The University of Alabama at Birmingham, Office of Psychiatric Research
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Arizona
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Tucson, Arizona, Verenigde Staten, 85719
- Center for Advanced Improvement
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California
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Imperial, California, Verenigde Staten, 92251
- Sun Valley Research Center
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Colorado
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Colorado Springs, Colorado, Verenigde Staten, 80910
- MCB Clinical Research Centers
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Connecticut
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Hartford, Connecticut, Verenigde Staten, 06106
- Institute of Living/Hartford Hospital
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Florida
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Destin, Florida, Verenigde Staten, 32541
- SJS Clinical Research, Inc.
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Gainesville, Florida, Verenigde Staten, 32607
- Sarkis Clinical Trials
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Jacksonville, Florida, Verenigde Staten, 32256
- Clinical Neuroscience Solutions
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Orange City, Florida, Verenigde Staten, 32763
- Medical Research Group of Central Florida
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Orlando, Florida, Verenigde Staten, 32839
- Millenia Psychiatry & Research, Inc.
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West Palm Beach, Florida, Verenigde Staten, 33407
- Janus Center For Psychiatric Research
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Georgia
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Marietta, Georgia, Verenigde Staten, 30060
- Northwest Behavioral Research Center
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Illinois
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Libertyville, Illinois, Verenigde Staten, 60048
- Capstone Clinical Research
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Naperville, Illinois, Verenigde Staten, 60563
- Baber Research Group
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Indiana
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Terre Haute, Indiana, Verenigde Staten, 47802
- Clinco
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Maryland
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Baltimore, Maryland, Verenigde Staten, 21208
- Pharmasite Research, Inc
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Missouri
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Creve Coeur, Missouri, Verenigde Staten, 63141
- Millennium Psychiatric Associates, LLC
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Nebraska
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Lincoln, Nebraska, Verenigde Staten, 68526
- Premier Psychiatric Research Institute, LLC
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New York
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Buffalo, New York, Verenigde Staten, 14215
- Erie County Medical Center/State University of New York (SUNY) at Buffalo Affiliate
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Glen Oaks, New York, Verenigde Staten, 11004
- The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System
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Mount Kisco, New York, Verenigde Staten, 10549
- Bioscience Research, LLC.
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Rochester, New York, Verenigde Staten, 14618
- Finger Lakes Clinical Research
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Stony Brook, New York, Verenigde Staten, 11794-8790
- Stony Brook University Medical Center, Child And Adolescent Psychiatry
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Ohio
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Canton, Ohio, Verenigde Staten, 44718
- Neuro-Behavioral Clinical Research, Inc.
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Cleveland, Ohio, Verenigde Staten, 44106
- Discovery and Wellness Center for Children/University Hospitals Case Medical Center
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Oklahoma
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Oklahoma City, Oklahoma, Verenigde Staten, 73112
- Sooner Clinical Research
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Tennessee
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Memphis, Tennessee, Verenigde Staten, 38119
- Research Strategies of Memphis, LLC.
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Texas
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Austin, Texas, Verenigde Staten, 78731
- FutureSearch Trials
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San Antonio, Texas, Verenigde Staten, 78229
- Clinical Trials of Texas, Inc.
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San Antonio, Texas, Verenigde Staten, 78229
- Clinical Trials of Texas, Inc
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Virginia
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Richmond, Virginia, Verenigde Staten, 23298
- Virginia Commonwealth University
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Richmond, Virginia, Verenigde Staten, 23230
- Alliance Research Group
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Richmond, Virginia, Verenigde Staten, 23230
- Allance Research Group
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Richmond, Virginia, Verenigde Staten, 23298
- Virginia Treatment Center For Children
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Washington
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Kirkland, Washington, Verenigde Staten, 98033
- Eastside Therapeutic Resource
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Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
7 jaar tot 17 jaar (Kind)
Accepteert gezonde vrijwilligers
Nee
Geslachten die in aanmerking komen voor studie
Allemaal
Beschrijving
Inclusion Criteria:
- Completed study B2061032 and who in the investigator's opinion, would benefit from long term treatment with DVS SR
- Willingness and ability to comply with scheduled visits, treatment plan, and procedures
Exclusion Criteria:
- Requires precaution against suicide
- Not in generally healthy medical condition
- Poor compliance with study drug or study procedures during participation in study B2061032
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Behandeling
- Toewijzing: NVT
- Interventioneel model: Opdracht voor een enkele groep
- Masker: Geen (open label)
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
|---|---|
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Experimenteel: Desvenlafaxine Succinate Sustained-Release
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Subjects will receive a flexible-dose of 20, 25, 35, or 50 mg/day as prescribed by the investigator
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Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Percentage of Participants With a Treatment-emergent Adverse Event (TEAE)
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
A TEAE was defined as an event that was absent before treatment and emerged or worsened during the treatment period.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
|
Percentage of Participants With a Treatment-emergent Adverse Event (TEAE) (Combination Group)
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
A TEAE was defined as an event that was absent before treatment and emerged or worsened during the treatment period.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Change From Baseline to Week 26 in Total Score on the Children's Depression Rating Scale, Revised (CDRS-R), Based on Observed Cases
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
The CDRS-R consists of 17 items.
The total score is the sum of responses to the 17 items and ranges from 17 to 113.
Lower total scores indicate lower intensity of symptoms.
Remission on the CDRS-R was defined as a CDRS-R score <=28.
It was recommended that the CDRS-R be performed prior to the Clinical Global Impression assessments.
Mean change from baseline=score at Week 26 minus score at baseline of study B2061032.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
|
Change From Baseline to Week 26 in Total Score on the Children's Depression Rating Scale, Revised (CDRS-R), Based on Observed Cases (Combination Group)
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
The CDRS-R consists of 17 items.
The total score is the sum of responses to the 17 items and ranges from 17 to 113.
Lower total scores indicate lower intensity of symptoms.
Remission on the CDRS-R was defined as a CDRS-R score <=28.
It was recommended that the CDRS-R be performed prior to the Clinical Global Impression assessments.
Mean change from baseline=score at Week 26 minus score at baseline of study B2061032.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
|
Change in Score From Baseline to Week 26 on the Clinical Global Impression-Severity (CGI-S) Scale, Based on Observed Cases
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
The Clinical Global Impression (CGI) Scale is a tool that summarizes all available patient data, including history, symptoms, behavior, and the impact of the symptoms on ability to function.
The scale consists of 2 measures: the CGI-S, which rates the severity of illness from 1 to 7, and the CGI-Improvement Scale, which assesses improvement in illness since baseline.
The CGI-S is a 7-point scale a clinician uses to rate a patient's severity of illness.
Scores range from 1 to 7, with 1 indicating "normal, not at all ill" and 7, "among the most extremely ill patients."
Higher score on the CGI-S indicates greater severity of illness.
Mean change from baseline=score at Week 26 minus score at baseline of study B2061032.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
|
Change in Score From Baseline to Week 26 on the Clinical Global Impression-Severity (CGI-S) Scale, Based on Observed Cases (Combination Group)
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
The Clinical Global Impression (CGI) Scale is a tool that summarizes all available patient data, including history, symptoms, behavior, and the impact of the symptoms on ability to function.
The scale consists of 2 measures: the CGI-S, which rates the severity of illness from 1 to 7, and the CGI-Improvement Scale, which assesses improvement in illness since baseline.
The CGI-S is a 7-point scale a clinician uses to rate a patient's severity of illness.
Scores range from 1 to 7, with 1 indicating "normal, not at all ill" and 7, "among the most extremely ill patients."
Higher score on the CGI-S indicates greater severity of illness.
Mean change from baseline=score at Week 26 minus score at baseline of study B2061032.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
|
Percentage of Participants With a Response of Very Much Improved or Much Improved on the Clinical Global Impression-Improvement (CGI-I) Scale at Week 26, Based on Observed Cases
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
The Clinical Global Impression (CGI) Scale is a tool that summarizes all available patient data, including history, symptoms, behavior, and the impact of the symptoms on ability to function.
The scale consists of 2 measures: the CGI-Severity scale, which rates the severity of illness from 1 to 7, and the CGI-I scale, which assesses improvement in illness since baseline.
The CGI-I is a 7-point scale a clinician uses to assess improvement in a patient's illness relative to baseline.
Scores range from 1 to 7, with 1 representing "very much improved" and 7 representing "very much worse"; a value of 0 meant not assessed.
Lower score indicates greater improvement.
Response on the CGI-I defined as the CGI-I scores of 1 or 2. Mean change from baseline=score at Week 26 minus score at baseline of study B2061032.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
|
Percentage of Participants With a Response of Very Much Improved or Much Improved on the Clinical Global Impression-Improvement (CGI-I) Scale at Week 26, Based on Observed Cases (Combination Group)
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
The Clinical Global Impression (CGI) Scale is a tool that summarizes all available patient data, including history, symptoms, behavior, and the impact of the symptoms on ability to function.
The scale consists of 2 measures: the CGI-Severity scale, which rates the severity of illness from 1 to 7, and the CGI-I scale, which assesses improvement in illness since baseline.
The CGI-I is a 7-point scale a clinician uses to assess improvement in a patient's illness relative to baseline.
Scores range from 1 to 7, with 1 representing "very much improved" and 7 representing "very much worse"; a value of 0 meant not assessed.
Lower score indicates greater improvement.
Response on the CGI-I defined as the CGI-I scores of 1 or 2. Mean change from baseline=score at Week 26 minus score at baseline of study B2061032.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
|
Percentage of Participants by Score on the Clinical Global Impression-Improvement (CGI-I) Scale, Based on Observed Cases
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
The Clinical Global Impression (CGI) Scale is a tool that summarizes all available patient data, including history, symptoms, behavior, and the impact of the symptoms on ability to function.
The scale consists of 2 measures: the CGI-Severity scale, which rates the severity of illness from 1 to 7, and the CGI-I scale, which assesses improvement in illness since baseline.
The CGI-I is a 7-point scale used a clinician uses to assess improvement in a patient's illness relative to baseline.
Scores range from 1 to 7, with 1 representing "very much improved" and 7 representing "very much worse"; a value of 0 meant not assessed.
Lower score indicates greater improvement.
Response on the CGI-I defined as the CGI-I scores of 1 or 2. Mean change from baseline=score at Week 26 minus score at baseline of study B2061032.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
|
Percentage of Participants by Score on the Clinical Global Impression-Improvement (CGI-I) Scale, Based on Observed Cases (Combination Group)
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
The Clinical Global Impression (CGI) Scale is a tool that summarizes all available patient data, including history, symptoms, behavior, and the impact of the symptoms on ability to function.
The scale consists of 2 measures: the CGI-Severity scale, which rates the severity of illness from 1 to 7, and the CGI-I scale, which assesses improvement in illness since baseline.
The CGI-I is a 7-point scale used a clinician uses to assess improvement in a patient's illness relative to baseline.
Scores range from 1 to 7, with 1 representing "very much improved" and 7 representing "very much worse"; a value of 0 meant not assessed.
Lower score indicates greater improvement.
Response on the CGI-I defined as the CGI-I scores of 1 or 2. Mean change from baseline=score at Week 26 minus score at baseline of study B2061032.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
|
Percentage of Participants With Remission at Week 26, Based on Score on the Children's Depression Rating Scale, Revised (CDRS-R), <=28 and on Observed Cases
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
Remission on the CDRS-R was defined as a CDRS-R score <=28.
The CDRS-R consists of 17 items.
The total score is the sum of responses to the 17 items and ranges from 17 to 113.
Lower total s cores indicate lower intensity of symptoms.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
|
Percentage of Participants With Remission at Week 26, Based on a Score on the Children's Depression Rating Scale, Revised (CDRS-R), <=28 and on Observed Cases (Combination Group)
Tijdsspanne: From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
Remission on the CDRS-R was defined as a CDRS-R score <=28.
The CDRS-R consists of 17 items.
The total score is the sum of responses to the 17 items and ranges from 17 to 113.
Lower total s cores indicate lower intensity of symptoms.
|
From Week 8 (B2061032)/Day 1 (B2061030) to Week 26 of B2061030
|
Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Sponsor
Publicaties en nuttige links
De persoon die verantwoordelijk is voor het invoeren van informatie over het onderzoek stelt deze publicaties vrijwillig ter beschikking. Dit kan gaan over alles wat met het onderzoek te maken heeft.
Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start (Werkelijk)
2 februari 2012
Primaire voltooiing (Werkelijk)
22 april 2016
Studie voltooiing (Werkelijk)
22 april 2016
Studieregistratiedata
Eerst ingediend
9 juni 2011
Eerst ingediend dat voldeed aan de QC-criteria
10 juni 2011
Eerst geplaatst (Schatting)
13 juni 2011
Updates van studierecords
Laatste update geplaatst (Werkelijk)
27 juli 2017
Laatste update ingediend die voldeed aan QC-criteria
28 juni 2017
Laatst geverifieerd
1 juni 2017
Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- B2061030
- 3151A6-3344 (Andere identificatie: Alias Study Number)
- 2008-001876-67 (EudraCT-nummer)
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Ja
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
Nee
Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .