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Efficacy of Computer-Based Cognitive Game Training for Healthy Elderly

9 augustus 2020 bijgewerkt door: National Taiwan University Hospital

Efficacy of Computer-Based Cognitive Game Training on Motor and Cognitive Functions for Healthy Elderly

The declination on cognitive and motor functions in older adults increases the difficulty to achieve successful aging. Previous studies had reported that contrast to the traditional cognitive training methods, computer cognitive training (CCT) is comparable or has better effect on the cognitive function improvement with elders.On the other hand, some researchers claimed motor-cognitive dual-task training may possess greater effects than single cognitive training on cognitive functions. However, it is still on debate. Therefore, the research aims to investigate cognitive and motor benefits to healthy older adults over 65s trained by our computer-based cognitive game with high and low level of motor engagements.The research questions include: (1) Is CCT beneficial of cognitive functions? (2) Does CCT with high level of motor engagements (i.e. motor-cognitive dual-task training) have greater effects than single cognitive training on cognitive functions? (3) Can the training effect remain?

Studie Overzicht

Toestand

Voltooid

Conditie

Interventie / Behandeling

Gedetailleerde beschrijving

Quasi-experimental design was adapted in our research.There are four time-series assessments during the experiment: baseline, pretest, posttest, and follow-up. After the baseline assessment, participants were randomized to two groups: gross-motor group (GMG) and fine-motor group (FMG). The intervals between baseline and pretest as well as between pretest and posttest were both 4 weeks, while the interval between posttest and follow-up was 8 weeks.

The investigators developed a computer-based cognitive game and compared the efficacy of cognitive and motor functions between computer-based cognitive game combining two different demands on motor control. Investigators hypothesized: All participants who take part in the computer-based cognitive game training don't have learning effects on pretest and are able to improve cognitive functions including short-term memory, divided attention and inhibitory function after intervention; Gross-motor group make more progress than fine-motor group on cognitive and motor functions after intervention. Furthermore, gross-motor group maintained more training effect over cognitive and motor functions at follow-up than fine-motor group.

Studietype

Ingrijpend

Inschrijving (Werkelijk)

16

Fase

  • Niet toepasbaar

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studie Locaties

  • Taiwan
      • Taipei, Taiwan, 100
        • National Taiwan University Hospital

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

65 jaar en ouder (Oudere volwassene)

Accepteert gezonde vrijwilligers

Nee

Geslachten die in aanmerking komen voor studie

Allemaal

Beschrijving

Inclusion Criteria:

  1. ≥ 65 years old
  2. Montreal Cognitive Assessment (MoCA) score ≥ 18
  3. clear eyesight and hearing
  4. both upper and lower limbs are functional
  5. normal communication

Exclusion Criteria:

  1. injury, fracture, and breathing problem
  2. surgery during the research
  3. severe disease affecting cognitive functions.

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

  • Primair doel: Onderzoek naar gezondheidsdiensten
  • Toewijzing: Gerandomiseerd
  • Interventioneel model: Parallelle opdracht
  • Masker: Geen (open label)

Wapens en interventies

Deelnemersgroep / Arm
Interventie / Behandeling
Experimenteel: gross-motor group (GMG)

The participants of GMG received motor-cognitive dual-task training. The sensors used by the participants were four different colored buttons. The participants wear a suit with two buttons on the shoulders and the other two fasten on the knees by velcros. To accomplish the tasks, the participants had to slap the correct colored buttons. The stretching of upper or lower limbs was demanding while slapping, so the participants of GMG received a training which required cognitive and motor functions at the same time.

The participants attended 2 sessions per week and lasted for 4 weeks. Each session lasted 75 minutes, mainly including 30 minutes for game introduction and warm-up, 30 minutes for game training, and 15 minutes for rest during the training. Each task lasted 10 minutes, and each session contained 3 tasks. The game difficulty could be adjusted automatically according to the performance of participants.
Apparaat: computer-based cognitive game (including 3 training tasks)

First task was short-term memory training. Participants were instructed to memorize different colored circles with ordinal numbers which would disappear later. They triggered correct colored sensor in sequence according to their memory.

Second task was divided attention training. Different colored circles with ordinal numbers would not disappear this time.The participants should trigger correct colored sensor according to their sequence.

Third task was inhibitory function training. There were red and green lights, just like the traffic light, hung up at the upper left of the scene. Red light represented prohibition of triggering the colored sensor, while green light urged to trigger it. Yellow, red, blue and green circles showed up randomly and moved toward the beige region. When the circle came extremely closer to the beige region, the traffic light was randomized to lighten up red or green.The participants should judge and trigger the correct colored sensor.
Actieve vergelijker: fine-motor group (FMG)

The participants of FMG received cognitive training only. Four colored sensors used by the participants were the keys on the keyboard of the laptop. The participants simply pressed correct colored keys by fingers to complete the tasks.

The participants attended 2 sessions per week and lasted for 4 weeks. Each session lasted 75 minutes, mainly including 30 minutes for game introduction and warm-up, 30 minutes for game training, and 15 minutes for rest during the training. Each task lasted 10 minutes, and each session contained 3 tasks. The game difficulty could be adjusted automatically according to the performance of participants.
Apparaat: computer-based cognitive game (including 3 training tasks)

First task was short-term memory training. Participants were instructed to memorize different colored circles with ordinal numbers which would disappear later. They triggered correct colored sensor in sequence according to their memory.

Second task was divided attention training. Different colored circles with ordinal numbers would not disappear this time.The participants should trigger correct colored sensor according to their sequence.

Third task was inhibitory function training. There were red and green lights, just like the traffic light, hung up at the upper left of the scene. Red light represented prohibition of triggering the colored sensor, while green light urged to trigger it. Yellow, red, blue and green circles showed up randomly and moved toward the beige region. When the circle came extremely closer to the beige region, the traffic light was randomized to lighten up red or green.The participants should judge and trigger the correct colored sensor.

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Change from Baseline Montreal Cognitive Assessment (MoCA) Taiwan Version at the 4th, 8th and 16th weeks
Tijdsspanne: baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
overall cognitive function
baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
Change from Baseline Digit Span Task-forward (DS-forward) at the 4th, 8th and 16th weeks
Tijdsspanne: baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
short-term memory
baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
Change from Baseline Color Trails Test-2 (CTT-2) at the 4th, 8th and 16th weeks
Tijdsspanne: baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
divided attention
baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
Change from Baseline Stroop Color Word Test (SCWT) at the 4th, 8th and 16th weeks
Tijdsspanne: baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
inhibitory function
baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
Change from Baseline Nine Hole Peg Test (NHPT) at the 4th, 8th and 16th weeks
Tijdsspanne: baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
motor function of upper limbs
baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
Change from Baseline Get-Up and Go Test (GUG) at the 4th, 8th and 16th weeks
Tijdsspanne: baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
motor function of lower limbs and balance
baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
Change from Baseline Five-Times-Sit-to-Stand Test (FTSST) at the 4th, 8th and 16th weeks
Tijdsspanne: baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up
motor function of lower limbs and balance
baseline, 4th weeks pretest, 8th weeks posttest, 16th weeks follow-up

Secundaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Change from 4th weeks Game1 (first scenario) evaluated the performance of short-term memory at 8th weeks
Tijdsspanne: 4th weeks pretest, 8th weeks posttest
Game assessment was a new way to evaluate cognitive performance of the participant through the score. All participants proceeded all three scenarios but challenged same degree of difficulty.
4th weeks pretest, 8th weeks posttest
Change from 4th weeks Game2 (second scenario) evaluated divided attention at 8th weeks
Tijdsspanne: 4th weeks pretest, 8th weeks posttest
Game assessment was a new way to evaluate cognitive performance of the participant through the score. All participants proceeded all three scenarios but challenged same degree of difficulty.
4th weeks pretest, 8th weeks posttest
Change from 4th weeks Game3 (third scenario) evaluated inhibitory function at 8th weeks
Tijdsspanne: 4th weeks pretest, 8th weeks posttest
Game assessment was a new way to evaluate cognitive performance of the participant through the score. All participants proceeded all three scenarios but challenged same degree of difficulty.
4th weeks pretest, 8th weeks posttest

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

National Taiwan University Hospital

Onderzoekers

  • Hoofdonderzoeker: Central Contact Backup Mao, National Taiwan University Hospital

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Werkelijk)

1 mei 2018

Primaire voltooiing (Werkelijk)

27 juni 2018

Studie voltooiing (Werkelijk)

27 juni 2018

Studieregistratiedata

Eerst ingediend

5 mei 2019

Eerst ingediend dat voldeed aan de QC-criteria

5 mei 2019

Eerst geplaatst (Werkelijk)

7 mei 2019

Updates van studierecords

Laatste update geplaatst (Werkelijk)

11 augustus 2020

Laatste update ingediend die voldeed aan QC-criteria

9 augustus 2020

Laatst geverifieerd

1 augustus 2020

Meer informatie

Termen gerelateerd aan deze studie

Andere studie-ID-nummers

  • 201804055RINC

Plan Individuele Deelnemersgegevens (IPD)

Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?

Nee

Informatie over medicijnen en apparaten, studiedocumenten

Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel

Nee

Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct

Nee

product vervaardigd in en geëxporteerd uit de V.S.

Nee

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