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Kjemoterapi med eller uten bevacizumab ved behandling av pasienter med stadium IB, stadium II eller stadium IIIA ikke-småcellet lungekreft som ble fjernet ved kirurgi

16. april 2024 oppdatert av: National Cancer Institute (NCI)

En randomisert fase III-studie av adjuvant kjemoterapi med eller uten Bevacizumab for pasienter med fullstendig reseksjonert stadium IB (≥ 4 cm) - IIIA ikke-småcellet lungekreft (NSCLC)

Denne randomiserte fase III-studien studerer kjemoterapi og bevacizumab for å se hvor godt de virker sammenlignet med kjemoterapi alene ved behandling av pasienter med stadium IB, stadium II eller stadium IIIA ikke-småcellet lungekreft som ble fjernet ved kirurgi. Legemidler som brukes i kjemoterapi virker på forskjellige måter for å stoppe veksten av tumorceller, enten ved å drepe cellene, ved å hindre dem i å dele seg, eller ved å hindre dem i å spre seg. Å gi mer enn ett medikament (kombinasjonskjemoterapi) kan drepe flere tumorceller. Monoklonale antistoffer, som bevacizumab, kan forstyrre tumorcellenes evne til å vokse og spre seg. Bevacizumab kan også stoppe veksten av ikke-småcellet lungekreft ved å blokkere veksten av nye blodkar som er nødvendige for tumorvekst. Det er ennå ikke kjent om kjemoterapi er mer effektiv med eller uten bevacizumab ved behandling av ikke-småcellet lungekreft.

Studieoversikt

Status

Aktiv, ikke rekrutterende

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

PRIMÆRE MÅL:

I. For å evaluere total overlevelse med kjemoterapi med eller uten bevacizumab brukt i adjuvant setting hos pasienter med reseksjonert stadium IB (>= 4 cm) - IIIA ikke-småcellet lungekreft (NSCLC).

SEKUNDÆRE MÅL:

I. For å evaluere sykdomsfri overlevelse og toksisitet med kjemoterapi med eller uten bevacizumab brukt i adjuvant setting hos pasienter med reseksjonert stadium IB (>= 4 cm) - IIIA NSCLC.

KORRELATIVE MÅL:

I. Å utføre analyser av vev og blod for å etablere faktorer som forutsier klinisk utfall hos pasienter som får kjemoterapi, med eller uten bevacizumab, for resekert tidlig stadium av NSCLC.

II. For å bestemme om røykestatus er knyttet til utfall for pasienter med reseksjonert stadium IB (>= 4 cm) - IIIA NSCLC behandlet med kjemoterapi med eller uten bevacizumab i adjuvant setting.

OVERSIKT: Pasienter er randomisert til 1 av 2 behandlingsarmer.

ARM I (adjuvant kjemoterapi uten bevacizumab): Pasienter får 1 av 4 kjemoterapiregimer.

REGIMEN 1: Pasienter får vinorelbin-ditartrat intravenøst (IV) over 10 minutter på dag 1 og 8 og cisplatin IV over 60 minutter på dag 1 umiddelbart etter administrering av vinorelbin-ditartrat.

REGIMEN 2: Pasienter får docetaxel IV over 1 time på dag 1 og cisplatin over 1 time på dag 1 umiddelbart etter administrering av docetaksel.

REGIMEN 3: Pasienter får gemcitabinhydroklorid IV over 30 minutter på dag 1 og 8 og cisplatin IV over 60 minutter på dag 1 umiddelbart etter administrering av gemcitabin.

REGIMEN 4 (kun ikke-plateepitel histologi): Pasienter får pemetrexed dinatrium IV over 10 minutter og cisplatin IV over 1 time på dag 1 umiddelbart etter administrering av pemetrexed dinatrium.

I alle regimer gjentas behandlingen hver 21. dag i opptil 4 kurer i fravær av sykdomsprogresjon eller uakseptabel toksisitet.

ARM II (adjuvant kjemoterapi med bevacizumab): Pasienter får kjemoterapi som i arm I. Pasienter får også bevacizumab IV over 30-90 minutter på dag 1. Behandling med bevacizumab gjentas hver 21. dag i opptil 1 år.

Etter avsluttet studiebehandling følges pasientene opp periodisk i 10 år.

Studietype

Intervensjonell

Registrering (Faktiske)

1501

Fase

Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

Canada
- Alberta
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute
- British Columbia
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - BCCA-Vancouver Cancer Centre
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- New Brunswick
  - Moncton, New Brunswick, Canada, E1C 6Z8
    - The Moncton Hospital
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - QEII Health Sciences Centre/Nova Scotia Health Authority
- Ontario
  - Barrie, Ontario, Canada, L4M 6M2
    - Royal Victoria Regional Health Centre
  - London, Ontario, Canada, N6A 4L6
    - London Regional Cancer Program
  - Mississauga, Ontario, Canada, L5B 1B8
    - Trillium Health Partners - Mississauga Hospital
  - Ottawa, Ontario, Canada, K1H 8L6
    - Ottawa Hospital and Cancer Center-General Campus
  - Sault Ste Marie, Ontario, Canada, P6B 0A8
    - Algoma District Cancer Program Sault Area Hospital
  - Sudbury, Ontario, Canada, P3E 5J1
    - Health Sciences North
  - Thunder Bay, Ontario, Canada, P7B 6V4
    - Thunder Bay Regional Health Science Centre
  - Toronto, Ontario, Canada, M5G 2M9
    - University Health Network-Princess Margaret Hospital
  - Toronto, Ontario, Canada, M9C 1A5
    - Trillium Health Partners - Queensway Health Centre
- Quebec
  - Greenfield Park, Quebec, Canada, J4V 2H1
    - CSSS Champlain-Charles Le Moyne
  - Montreal, Quebec, Canada, H2W 1S6
    - McGill University Department of Oncology
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre
Forente stater
- Alabama
  - Anniston, Alabama, Forente stater, 36202
    - Northeast Alabama Regional Medical Center
  - Huntsville, Alabama, Forente stater, 35805
    - Clearview Cancer Institute
  - Mobile, Alabama, Forente stater, 36688
    - University of South Alabama Mitchell Cancer Institute
  - Mobile, Alabama, Forente stater, 36608
    - Providence Hospital
- Alaska
  - Anchorage, Alaska, Forente stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Regional Hospital
- Arizona
  - Scottsdale, Arizona, Forente stater, 85259
    - Mayo Clinic in Arizona
  - Tucson, Arizona, Forente stater, 85704
    - University of Arizona Cancer Center-Orange Grove Campus
  - Tucson, Arizona, Forente stater, 85719
    - Banner University Medical Center - Tucson
  - Tucson, Arizona, Forente stater, 85719
    - University of Arizona Cancer Center-North Campus
- Arkansas
  - Fort Smith, Arkansas, Forente stater, 72903
    - Mercy Hospital Fort Smith
  - Jonesboro, Arkansas, Forente stater, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
  - Jonesboro, Arkansas, Forente stater, 72401
    - NEA Baptist Memorial Hospital
  - Jonesboro, Arkansas, Forente stater, 72401
    - Saint Bernards Regional Medical Center
  - Little Rock, Arkansas, Forente stater, 72205
    - University of Arkansas for Medical Sciences
  - Little Rock, Arkansas, Forente stater, 72205
    - John L McClellan Memorial Veterans Hospital
- California
  - Anaheim, California, Forente stater, 92806
    - Kaiser Permanente-Anaheim
  - Antioch, California, Forente stater, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Arroyo Grande, California, Forente stater, 93420
    - PCR Oncology
  - Baldwin Park, California, Forente stater, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Forente stater, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Forente stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forente stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forente stater, 94010
    - Mills-Peninsula Medical Center
  - Castro Valley, California, Forente stater, 94546
    - Eden Hospital Medical Center
  - Castro Valley, California, Forente stater, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Forente stater, 94546
    - Valley Medical Oncology Consultants-Castro Valley
  - Chico, California, Forente stater, 95973
    - Adventist Health Cancer Care Center Chico
  - Clovis, California, Forente stater, 93611
    - Community Cancer Institute
  - Duarte, California, Forente stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Emeryville, California, Forente stater, 94608
    - Bay Area Breast Surgeons Inc
  - Emeryville, California, Forente stater, 94608
    - Epic Care Partners in Cancer Care
  - Fontana, California, Forente stater, 92335
    - Kaiser Permanente-Fontana
  - Fremont, California, Forente stater, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Forente stater, 94538
    - Valley Medical Oncology Consultants-Fremont
  - Fresno, California, Forente stater, 93720
    - Kaiser Permanente-Fresno
  - Fresno, California, Forente stater, 93720
    - California Cancer Associates for Research and Excellence (cCare)
  - Fullerton, California, Forente stater, 92835
    - Saint Jude Medical Center
  - Glendale, California, Forente stater, 91204
    - Glendale Memorial Hospital and Health Center
  - Greenbrae, California, Forente stater, 94904
    - Marin Cancer Care Inc
  - Greenbrae, California, Forente stater, 94904
    - Marin General Hospital
  - Harbor City, California, Forente stater, 90710
    - Kaiser Permanente - Harbor City
  - Hayward, California, Forente stater, 94545
    - Saint Rose Hospital
  - Irvine, California, Forente stater, 92618
    - Kaiser Permanente-Irvine
  - Loma Linda, California, Forente stater, 92354
    - Loma Linda University Medical Center
  - Long Beach, California, Forente stater, 90806
    - Long Beach Memorial Medical Center-Todd Cancer Institute
  - Los Angeles, California, Forente stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Forente stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forente stater, 90034
    - Kaiser Permanente West Los Angeles
  - Los Angeles, California, Forente stater, 90033
    - Los Angeles General Medical Center
  - Martinez, California, Forente stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Marysville, California, Forente stater, 95901
    - Fremont - Rideout Cancer Center
  - Merced, California, Forente stater, 95340
    - Mercy UC Davis Cancer Center
  - Modesto, California, Forente stater, 95355
    - Memorial Medical Center
  - Modesto, California, Forente stater, 95356
    - Kaiser Permanente-Modesto
  - Monterey, California, Forente stater, 93940
    - Community Hospital of Monterey Peninsula
  - Mountain View, California, Forente stater, 94040
    - El Camino Hospital
  - Mountain View, California, Forente stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Novato, California, Forente stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forente stater, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, Forente stater, 94611
    - Kaiser Permanente Oakland-Broadway
  - Oakland, California, Forente stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forente stater, 94609
    - Hematology and Oncology Associates-Oakland
  - Oakland, California, Forente stater, 94602
    - Highland General Hospital
  - Oakland, California, Forente stater, 94609
    - Tom K Lee Inc
  - Oakland, California, Forente stater, 94609
    - Bay Area Tumor Institute
  - Orange, California, Forente stater, 92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Orange, California, Forente stater, 92868
    - Saint Joseph Hospital - Orange
  - Palm Springs, California, Forente stater, 92262
    - Desert Regional Medical Center
  - Palo Alto, California, Forente stater, 94304
    - Stanford Cancer Institute Palo Alto
  - Palo Alto, California, Forente stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City, California, Forente stater, 91402
    - Kaiser Permanente - Panorama City
  - Pleasanton, California, Forente stater, 94588
    - Valley Care Health System - Pleasanton
  - Pleasanton, California, Forente stater, 94588
    - Valley Medical Oncology Consultants
  - Pomona, California, Forente stater, 91767
    - Pomona Valley Hospital Medical Center
  - Rancho Cordova, California, Forente stater, 95670
    - Kaiser Permanente-Rancho Cordova Cancer Center
  - Rancho Mirage, California, Forente stater, 92270
    - Eisenhower Medical Center
  - Redwood City, California, Forente stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forente stater, 94801
    - Kaiser Permanente-Richmond
  - Riverside, California, Forente stater, 92505
    - Kaiser Permanente-Riverside
  - Rohnert Park, California, Forente stater, 94928
    - Rohnert Park Cancer Center
  - Roseville, California, Forente stater, 95678
    - The Permanente Medical Group-Roseville Radiation Oncology
  - Roseville, California, Forente stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forente stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forente stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forente stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forente stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forente stater, 95823
    - South Sacramento Cancer Center
  - Sacramento, California, Forente stater, 95825
    - Kaiser Permanente - Sacramento
  - Sacramento, California, Forente stater, 95819
    - Mercy General Hospital
  - Saint Helena, California, Forente stater, 94574
    - Saint Helena Hospital
  - Salinas, California, Forente stater, 93901
    - Salinas Valley Memorial
  - San Diego, California, Forente stater, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Forente stater, 92108
    - Kaiser Permanente-San Diego Mission
  - San Francisco, California, Forente stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forente stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, Forente stater, 94115
    - UCSF Medical Center-Mount Zion
  - San Francisco, California, Forente stater, 94110
    - Zuckerberg San Francisco General Hospital
  - San Jose, California, Forente stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forente stater, 94577
    - Kaiser Permanente San Leandro
  - San Marcos, California, Forente stater, 92078
    - Kaiser Permanente-San Marcos
  - San Pablo, California, Forente stater, 94806
    - Doctors Medical Center- JC Robinson Regional Cancer Center
  - San Rafael, California, Forente stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forente stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Rosa, California, Forente stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forente stater, 95403
    - Sutter Pacific Medical Foundation
  - Santa Rosa, California, Forente stater, 95405
    - Providence Santa Rosa Memorial Hospital
  - South San Francisco, California, Forente stater, 94080
    - Kaiser Permanente Cancer Treatment Center
  - South San Francisco, California, Forente stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forente stater, 95210
    - Kaiser Permanente-Stockton
  - Sunnyvale, California, Forente stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Truckee, California, Forente stater, 96161
    - Gene Upshaw Memorial Tahoe Forest Cancer Center
  - Vacaville, California, Forente stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vacaville, California, Forente stater, 95687
    - Northbay Cancer Center
  - Vallejo, California, Forente stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forente stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forente stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Woodland Hills, California, Forente stater, 91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Alamosa, Colorado, Forente stater, 81101
    - San Luis Valley Regional Medical Center
  - Aurora, Colorado, Forente stater, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, Forente stater, 80045
    - Rocky Mountain Regional VA Medical Center
  - Aurora, Colorado, Forente stater, 80045
    - UCHealth University of Colorado Hospital
  - Boulder, Colorado, Forente stater, 80301
    - Boulder Community Hospital
  - Colorado Springs, Colorado, Forente stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forente stater, 80909
    - UCHealth Memorial Hospital Central
  - Denver, Colorado, Forente stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forente stater, 80217-3364
    - University of Colorado
  - Denver, Colorado, Forente stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forente stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forente stater, 80218
    - SCL Health Saint Joseph Hospital
  - Denver, Colorado, Forente stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forente stater, 80204
    - Denver Health Medical Center
  - Denver, Colorado, Forente stater, 80222
    - Western States Cancer Research NCORP
  - Edwards, Colorado, Forente stater, 81632
    - Shaw Cancer Center
  - Englewood, Colorado, Forente stater, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Forente stater, 80524
    - Poudre Valley Hospital
  - Glenwood Springs, Colorado, Forente stater, 81601
    - Valley View Hospital Cancer Center
  - Grand Junction, Colorado, Forente stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Forente stater, 80631
    - North Colorado Medical Center
  - Lafayette, Colorado, Forente stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lakewood, Colorado, Forente stater, 80228
    - Saint Anthony Hospital
  - Littleton, Colorado, Forente stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forente stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forente stater, 80501
    - Longmont United Hospital
  - Loveland, Colorado, Forente stater, 80539
    - McKee Medical Center
  - Montrose, Colorado, Forente stater, 81401
    - Montrose Memorial Hospital
  - Parker, Colorado, Forente stater, 80138
    - Parker Adventist Hospital
  - Pueblo, Colorado, Forente stater, 81004
    - Saint Mary Corwin Medical Center
  - Thornton, Colorado, Forente stater, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Forente stater, 80033
    - SCL Health Lutheran Medical Center
- Connecticut
  - Bridgeport, Connecticut, Forente stater, 06610
    - Bridgeport Hospital
  - Bridgeport, Connecticut, Forente stater, 06606
    - Hartford HealthCare - Saint Vincent's Medical Center
  - Greenwich, Connecticut, Forente stater, 06830
    - Greenwich Hospital
  - Hartford, Connecticut, Forente stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford, Connecticut, Forente stater, 06102
    - Hartford Hospital
  - Meriden, Connecticut, Forente stater, 06451
    - Midstate Medical Center
  - Middletown, Connecticut, Forente stater, 06457
    - Middlesex Hospital
  - New Britain, Connecticut, Forente stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forente stater, 06520
    - Yale University
  - Norwalk, Connecticut, Forente stater, 06856
    - Norwalk Hospital
  - Norwich, Connecticut, Forente stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Stamford, Connecticut, Forente stater, 06904
    - Stamford Hospital/Bennett Cancer Center
  - Torrington, Connecticut, Forente stater, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Waterbury, Connecticut, Forente stater, 06708
    - Harold Leever Regional Cancer Center
- Delaware
  - Dover, Delaware, Forente stater, 19901
    - Bayhealth Hospital Kent Campus
  - Lewes, Delaware, Forente stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forente stater, 19718
    - Christiana Care Health System-Christiana Hospital
- District of Columbia
  - Washington, District of Columbia, Forente stater, 20010
    - MedStar Washington Hospital Center
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    - Medstar Georgetown University Hospital
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    - Sibley Memorial Hospital
  - Washington, District of Columbia, Forente stater, 20037
    - George Washington University Medical Center
- Florida
  - Boca Raton, Florida, Forente stater, 33486
    - Boca Raton Regional Hospital
  - Boca Raton, Florida, Forente stater, 33428
    - Lynn Regional Cancer Center - West
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    - Boca Raton Comprehensive Cancer Center
  - Daytona Beach, Florida, Forente stater, 32114
    - Halifax Health Medical Center-Centers for Oncology
  - Daytona Beach, Florida, Forente stater, 32117
    - Florida Hospital Memorial Medical Center
  - Fort Lauderdale, Florida, Forente stater, 33316
    - Broward Health Medical Center
  - Fort Lauderdale, Florida, Forente stater, 33308
    - Holy Cross Hospital
  - Gainesville, Florida, Forente stater, 32605
    - Florida Cancer Specialists-Gainesville Cancer Center
  - Hollywood, Florida, Forente stater, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Forente stater, 32207
    - Baptist MD Anderson Cancer Center
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    - Mayo Clinic in Florida
  - Jupiter, Florida, Forente stater, 33458
    - Jupiter Medical Center
  - Lakeland, Florida, Forente stater, 33805
    - Lakeland Regional Health Hollis Cancer Center
  - Lakeland, Florida, Forente stater, 33805
    - The Watson Clinic
  - Miami, Florida, Forente stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami Beach, Florida, Forente stater, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Forente stater, 32803
    - AdventHealth Orlando
  - Pensacola, Florida, Forente stater, 32504
    - Sacred Heart Hospital
  - Tampa, Florida, Forente stater, 33612
    - Moffitt Cancer Center
  - West Palm Beach, Florida, Forente stater, 33401
    - Florida Cancer Specialists-West Palm Beach
  - Weston, Florida, Forente stater, 33331
    - Cleveland Clinic-Weston
- Georgia
  - Albany, Georgia, Forente stater, 31701
    - Phoebe Putney Memorial Hospital
  - Athens, Georgia, Forente stater, 30607
    - University Cancer and Blood Center LLC
  - Atlanta, Georgia, Forente stater, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Forente stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forente stater, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Forente stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forente stater, 30342
    - Northside Hospital
  - Atlanta, Georgia, Forente stater, 30342
    - Atlanta Regional CCOP
  - Augusta, Georgia, Forente stater, 30912
    - Augusta University Medical Center
  - Augusta, Georgia, Forente stater, 30901
    - Augusta Oncology Associates PC-D'Antignac
  - Austell, Georgia, Forente stater, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, Forente stater, 31904
    - John B Amos Cancer Center
  - Decatur, Georgia, Forente stater, 30033
    - Dekalb Medical Center
  - Decatur, Georgia, Forente stater, 30033
    - Atlanta VA Medical Center
  - Fayetteville, Georgia, Forente stater, 30214
    - Piedmont Fayette Hospital
  - Gainesville, Georgia, Forente stater, 30501
    - Northeast Georgia Medical Center-Gainesville
  - Lawrenceville, Georgia, Forente stater, 30046
    - Northside Hospital - Gwinnett
  - Macon, Georgia, Forente stater, 31201
    - Medical Center of Central Georgia
  - Marietta, Georgia, Forente stater, 30060
    - Wellstar Kennestone Hospital
  - Riverdale, Georgia, Forente stater, 30274
    - Southern Regional Medical Center
  - Rome, Georgia, Forente stater, 30165
    - Harbin Clinic Medical Oncology and Clinical Research
  - Savannah, Georgia, Forente stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forente stater, 31404
    - Memorial Health University Medical Center
- Hawaii
  - 'Aiea, Hawaii, Forente stater, 96701
    - Pali Momi Medical Center
  - Honolulu, Hawaii, Forente stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forente stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forente stater, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Forente stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forente stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forente stater, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Forente stater, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, Forente stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forente stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Honolulu, Hawaii, Forente stater, 96859
    - Tripler Army Medical Center
  - Kailua, Hawaii, Forente stater, 96734
    - Castle Medical Center
  - Lihue, Hawaii, Forente stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
  - Wailuku, Hawaii, Forente stater, 96793
    - Maui Memorial Medical Center
  - Wailuku, Hawaii, Forente stater, 96793
    - Pacific Cancer Institute of Maui
- Idaho
  - Boise, Idaho, Forente stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forente stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Fruitland, Idaho, Forente stater, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Lewiston, Idaho, Forente stater, 83501
    - Saint Joseph Regional Medical Center
  - Meridian, Idaho, Forente stater, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Forente stater, 83686
    - Saint Luke's Cancer Institute - Nampa
  - Pocatello, Idaho, Forente stater, 83201
    - Portneuf Medical Center
  - Twin Falls, Idaho, Forente stater, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Alton, Illinois, Forente stater, 62002
    - Saint Anthony's Health
  - Aurora, Illinois, Forente stater, 60504
    - Rush - Copley Medical Center
  - Berwyn, Illinois, Forente stater, 60402
    - MacNeal Hospital and Cancer Center
  - Bloomington, Illinois, Forente stater, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Forente stater, 61701
    - Saint Joseph Medical Center
  - Canton, Illinois, Forente stater, 61520
    - Illinois CancerCare-Canton
  - Canton, Illinois, Forente stater, 61520
    - Graham Hospital Association
  - Carthage, Illinois, Forente stater, 62321
    - Illinois CancerCare-Carthage
  - Carthage, Illinois, Forente stater, 62321
    - Memorial Hospital
  - Chicago, Illinois, Forente stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forente stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forente stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forente stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forente stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forente stater, 60657
    - UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
  - Chicago, Illinois, Forente stater, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Forente stater, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Forente stater, 60611
    - Hematology and Oncology Associates
  - Chicago, Illinois, Forente stater, 60631
    - Presence Resurrection Medical Center
  - Chicago, Illinois, Forente stater, 60640
    - Weiss Memorial Hospital
  - Chicago, Illinois, Forente stater, 60612
    - Jesse Brown Veterans Affairs Medical Center
  - Decatur, Illinois, Forente stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forente stater, 62526
    - Heartland Cancer Research NCORP
  - Downers Grove, Illinois, Forente stater, 60515
    - Advocate Good Samaritan Hospital
  - Effingham, Illinois, Forente stater, 62401
    - Saint Anthony Memorial Hospital
  - Elgin, Illinois, Forente stater, 60123
    - Advocate Sherman Hospital
  - Elk Grove Village, Illinois, Forente stater, 60007
    - Ascension Alexian Brothers - Elk Grove Village
  - Elmhurst, Illinois, Forente stater, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, Forente stater, 61530
    - Illinois CancerCare-Eureka
  - Eureka, Illinois, Forente stater, 61530
    - Eureka Hospital
  - Evanston, Illinois, Forente stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Evanston, Illinois, Forente stater, 60202
    - Saint Francis Hospital
  - Galesburg, Illinois, Forente stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forente stater, 61401
    - Illinois CancerCare-Galesburg
  - Galesburg, Illinois, Forente stater, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, Forente stater, 61401
    - Illinois CancerCare-Cottage
  - Geneva, Illinois, Forente stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Geneva, Illinois, Forente stater, 60134
    - LaGrange Oncology Associates
  - Harvey, Illinois, Forente stater, 60426
    - Ingalls Memorial Hospital
  - Havana, Illinois, Forente stater, 62644
    - Mason District Hospital
  - Havana, Illinois, Forente stater, 62644
    - Illinois CancerCare-Havana
  - Highland Park, Illinois, Forente stater, 60035
    - Hematology Oncology Associates of Illinois-Highland Park
  - Hinsdale, Illinois, Forente stater, 60521
    - Hinsdale Hematology Oncology Associates Incorporated
  - Hopedale, Illinois, Forente stater, 61747
    - Hopedale Medical Complex - Hospital
  - Joliet, Illinois, Forente stater, 60435
    - Duly Health and Care Joliet
  - Joliet, Illinois, Forente stater, 60432
    - Midwest Center for Hematology Oncology
  - Kankakee, Illinois, Forente stater, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Forente stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - La Grange, Illinois, Forente stater, 60525
    - AMITA Health Adventist Medical Center
  - Libertyville, Illinois, Forente stater, 60048
    - AMG Libertyville - Oncology
  - Macomb, Illinois, Forente stater, 61455
    - Illinois CancerCare-Macomb
  - Macomb, Illinois, Forente stater, 61455
    - Mcdonough District Hospital
  - Maywood, Illinois, Forente stater, 60153
    - Loyola University Medical Center
  - Moline, Illinois, Forente stater, 61265
    - Garneau, Stewart C MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Porubcin, Michael MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Spector, David MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Trinity Medical Center
  - Moline, Illinois, Forente stater, 61265
    - Sharis, Christine M MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Stoffel, Thomas J MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Vigliotti, Antonio, P.G. M.D. (UIA Investigator)
  - Monmouth, Illinois, Forente stater, 61462
    - Illinois CancerCare-Monmouth
  - Monmouth, Illinois, Forente stater, 61462
    - Holy Family Medical Center
  - Mount Vernon, Illinois, Forente stater, 62864
    - Good Samaritan Regional Health Center
  - Naperville, Illinois, Forente stater, 60540
    - Edward Hospital/Cancer Center
  - Naperville, Illinois, Forente stater, 60563
    - DuPage Medical Group-Ogden
  - Niles, Illinois, Forente stater, 60714
    - Illinois Cancer Specialists-Niles
  - Normal, Illinois, Forente stater, 61761
    - Carle Cancer Institute Normal
  - Normal, Illinois, Forente stater, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, Forente stater, 61761
    - Illinois CancerCare-Community Cancer Center
  - Normal, Illinois, Forente stater, 61761
    - Mid-Illinois Hematology Oncology Associates Limited
  - Oak Lawn, Illinois, Forente stater, 60453-2699
    - Advocate Christ Medical Center
  - Ottawa, Illinois, Forente stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forente stater, 61350
    - Ottawa Regional Hospital and Healthcare Center
  - Pekin, Illinois, Forente stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forente stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
  - Pekin, Illinois, Forente stater, 61554
    - Pekin Hospital
  - Peoria, Illinois, Forente stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forente stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forente stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forente stater, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peoria, Illinois, Forente stater, 61614
    - Proctor Hospital
  - Peru, Illinois, Forente stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forente stater, 61354
    - Valley Radiation Oncology
  - Peru, Illinois, Forente stater, 61354
    - Illinois Valley Hospital
  - Princeton, Illinois, Forente stater, 61356
    - Illinois CancerCare-Princeton
  - Princeton, Illinois, Forente stater, 61356
    - Perry Memorial Hospital
  - River Forest, Illinois, Forente stater, 60305
    - West Suburban Medical Center
  - Rockford, Illinois, Forente stater, 61114
    - SwedishAmerican Regional Cancer Center/ACT
  - Rockford, Illinois, Forente stater, 61108
    - OSF Saint Anthony Medical Center
  - Rockford, Illinois, Forente stater, 61104
    - Swedish American Hospital
  - Skokie, Illinois, Forente stater, 60076
    - Hematology Oncology Associates of Illinois - Skokie
  - Skokie, Illinois, Forente stater, 60076
    - Edward H Kaplan MD and Associates
  - Spring Valley, Illinois, Forente stater, 61362
    - Saint Margaret's Hospital
  - Spring Valley, Illinois, Forente stater, 61362
    - Illinois CancerCare-Spring Valley
  - Springfield, Illinois, Forente stater, 62781
    - Memorial Medical Center
  - Urbana, Illinois, Forente stater, 61801
    - Carle Cancer Center
  - Warrenville, Illinois, Forente stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Winfield, Illinois, Forente stater, 60190
    - Northwestern Medicine Central DuPage Hospital
- Indiana
  - Anderson, Indiana, Forente stater, 46016
    - Ascension Saint Vincent Anderson
  - Beech Grove, Indiana, Forente stater, 46107
    - Franciscan Saint Francis Health-Beech Grove
  - Elkhart, Indiana, Forente stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forente stater, 46514
    - Michiana Hematology Oncology PC-Elkhart
  - Elkhart, Indiana, Forente stater, 46514-2098
    - Elkhart Clinic
  - Fort Wayne, Indiana, Forente stater, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Indianapolis, Indiana, Forente stater, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Forente stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forente stater, 46260
    - Ascension Saint Vincent Indianapolis Hospital
  - Indianapolis, Indiana, Forente stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Forente stater, 46202
    - Richard L. Roudebush Veterans Affairs Medical Center
  - Kokomo, Indiana, Forente stater, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Forente stater, 46350
    - IU Health La Porte Hospital
  - Lafayette, Indiana, Forente stater, 47904
    - IU Health Arnett Cancer Care
  - Merrillville, Indiana, Forente stater, 46410
    - Premier Oncology Hematology Associates
  - Michigan City, Indiana, Forente stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Mishawaka, Indiana, Forente stater, 46545
    - Michiana Hematology Oncology PC-Mishawaka
  - Mishawaka, Indiana, Forente stater, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Muncie, Indiana, Forente stater, 47303
    - IU Health Ball Memorial Hospital
  - Munster, Indiana, Forente stater, 46321
    - The Community Hospital
  - Plymouth, Indiana, Forente stater, 46563
    - Michiana Hematology Oncology PC-Plymouth
  - Richmond, Indiana, Forente stater, 47374
    - Reid Health
  - South Bend, Indiana, Forente stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forente stater, 46601
    - Michiana Hematology Oncology PC-South Bend
  - South Bend, Indiana, Forente stater, 46628
    - Northern Indiana Cancer Research Consortium
  - South Bend, Indiana, Forente stater, 46617
    - South Bend Clinic
  - Westville, Indiana, Forente stater, 46391
    - Michiana Hematology Oncology PC-Westville
- Iowa
  - Ames, Iowa, Forente stater, 50010
    - McFarland Clinic - Ames
  - Bettendorf, Iowa, Forente stater, 52722
    - Constantinou, Costas L MD (UIA Investigator)
  - Bettendorf, Iowa, Forente stater, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Cedar Rapids, Iowa, Forente stater, 52402
    - Saint Luke's Hospital
  - Cedar Rapids, Iowa, Forente stater, 52402
    - Physicians' Clinic of Iowa PC
  - Clive, Iowa, Forente stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Davenport, Iowa, Forente stater, 52803
    - Genesis Medical Center - East Campus
  - Davenport, Iowa, Forente stater, 52804
    - Genesis Cancer Care Institute
  - Des Moines, Iowa, Forente stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forente stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forente stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forente stater, 50314
    - Mission Cancer and Blood - Laurel
  - Des Moines, Iowa, Forente stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forente stater, 50309
    - Iowa-Wide Oncology Research Coalition NCORP
  - Des Moines, Iowa, Forente stater, 50307
    - Mercy Capitol
  - Iowa City, Iowa, Forente stater, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Mason City, Iowa, Forente stater, 50401
    - Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, Forente stater, 52501
    - Ottumwa Regional Health Center
  - Sioux City, Iowa, Forente stater, 51101
    - Siouxland Regional Cancer Center
  - Sioux City, Iowa, Forente stater, 51102
    - Mercy Medical Center-Sioux City
  - Sioux City, Iowa, Forente stater, 51104
    - Saint Luke's Regional Medical Center
  - Waterloo, Iowa, Forente stater, 50701
    - Cedar Valley Medical Specialists
  - Waterloo, Iowa, Forente stater, 50702
    - MercyOne Waterloo Cancer Center
  - West Des Moines, Iowa, Forente stater, 50266-7700
    - Methodist West Hospital
- Kansas
  - Anthony, Kansas, Forente stater, 67003
    - Hospital District Sixth of Harper County
  - Chanute, Kansas, Forente stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forente stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forente stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Fort Scott, Kansas, Forente stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Great Bend, Kansas, Forente stater, 67530
    - Saint Rose Ambulatory and Surgery Center
  - Hays, Kansas, Forente stater, 67601
    - HaysMed University of Kansas Health System
  - Hutchinson, Kansas, Forente stater, 67502
    - Hutchinson Regional Medical Center
  - Independence, Kansas, Forente stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forente stater, 66160
    - University of Kansas Cancer Center
  - Kansas City, Kansas, Forente stater, 66112
    - University of Kansas Cancer Center-West
  - Kansas City, Kansas, Forente stater, 66112
    - Providence Medical Center
  - Kingman, Kansas, Forente stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forente stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forente stater, 67905
    - Cancer Center of Kansas-Liberal
  - Liberal, Kansas, Forente stater, 67901
    - Southwest Medical Center
  - McPherson, Kansas, Forente stater, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Forente stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forente stater, 66061
    - Olathe Cancer Center
  - Overland Park, Kansas, Forente stater, 66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park, Kansas, Forente stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forente stater, 66213
    - Saint Luke's South Hospital
  - Parsons, Kansas, Forente stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Forente stater, 66762
    - Ascension Via Christi - Pittsburg
  - Prairie Village, Kansas, Forente stater, 66208
    - Kansas City NCI Community Oncology Research Program
  - Pratt, Kansas, Forente stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forente stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forente stater, 67401
    - Cancer Center of Kansas - Salina
  - Shawnee Mission, Kansas, Forente stater, 66204
    - Advent Health - Shawnee Mission Medical Center
  - Topeka, Kansas, Forente stater, 66606
    - University of Kansas Health System Saint Francis Campus
  - Topeka, Kansas, Forente stater, 66606
    - Cotton O'Neil Cancer Center / Stormont Vail Health
  - Wellington, Kansas, Forente stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forente stater, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Forente stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forente stater, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Forente stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forente stater, 67214
    - Wichita NCI Community Oncology Research Program
  - Winfield, Kansas, Forente stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Ashland, Kentucky, Forente stater, 41101
    - King's Daughter's Medical Center
  - Ashland, Kentucky, Forente stater, 41101
    - Our Lady Bellefonte Hospital
  - Lexington, Kentucky, Forente stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Louisville, Kentucky, Forente stater, 40202
    - The James Graham Brown Cancer Center at University of Louisville
  - Louisville, Kentucky, Forente stater, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Forente stater, 40215
    - Doctors Carrol, Sheth, Raghavan
  - Owensboro, Kentucky, Forente stater, 42303
    - Owensboro Health Mitchell Memorial Cancer Center
- Louisiana
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Forente stater, 70806
    - Baton Rouge General Medical Center
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Hematology/Oncology Clinic PLLC
  - Covington, Louisiana, Forente stater, 70433
    - Ochsner Health Center-Covington
  - Lafayette, Louisiana, Forente stater, 70503
    - Cancer Center of Acadiana
  - New Orleans, Louisiana, Forente stater, 70112
    - Tulane University School of Medicine
  - New Orleans, Louisiana, Forente stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forente stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forente stater, 70112
    - Louisiana State University Health Science Center
  - New Orleans, Louisiana, Forente stater, 70115
    - Ochsner Baptist Medical Center
- Maine
  - Augusta, Maine, Forente stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forente stater, 04401
    - Eastern Maine Medical Center
  - Lewiston, Maine, Forente stater, 04240
    - Central Maine Medical Center
  - Lewiston, Maine, Forente stater, 04240
    - Saint Mary's Regional Medical Center
  - Portland, Maine, Forente stater, 04101
    - Mercy Hospital
  - Scarborough, Maine, Forente stater, 04074
    - Maine Center for Cancer Medicine-Scarborough
  - Waterville, Maine, Forente stater, 04901
    - Maine General Medical Center-Thayer
  - York, Maine, Forente stater, 03909
    - York Hospital
- Maryland
  - Baltimore, Maryland, Forente stater, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Forente stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forente stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forente stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forente stater, 21201
    - University of Maryland/Greenebaum Cancer Center
  - Baltimore, Maryland, Forente stater, 21201
    - Veterans Administration Medical Center-Baltimore
  - Bel Air, Maryland, Forente stater, 21014
    - UM Upper Chesapeake Medical Center
  - Bethesda, Maryland, Forente stater, 20889-5600
    - Walter Reed National Military Medical Center
  - Cumberland, Maryland, Forente stater, 21502
    - UPMC Western Maryland
  - Easton, Maryland, Forente stater, 21601
    - University of Maryland Shore Medical Center at Easton
  - Elkton, Maryland, Forente stater, 21921
    - Christiana Care - Union Hospital
  - Frederick, Maryland, Forente stater, 21701
    - Frederick Memorial Hospital
  - Hagerstown, Maryland, Forente stater, 21742
    - Meritus Medical Center
  - Kensington, Maryland, Forente stater, 20895
    - Associates in Oncology Hematology PC -Kensington
  - Rockville, Maryland, Forente stater, 20850
    - Maryland Oncology Hematology PA-Aquilino Cancer Center
  - Salisbury, Maryland, Forente stater, 21801
    - TidalHealth Peninsula Regional
  - Silver Spring, Maryland, Forente stater, 20910
    - Holy Cross Hospital
  - Towson, Maryland, Forente stater, 21204
    - UM Saint Joseph Medical Center
- Massachusetts
  - Attleboro, Massachusetts, Forente stater, 02703
    - Sturdy Memorial Hospital
  - Beverly, Massachusetts, Forente stater, 01915
    - Beverly Hospital
  - Boston, Massachusetts, Forente stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forente stater, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forente stater, 02115
    - Brigham and Women's Hospital
  - Boston, Massachusetts, Forente stater, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Forente stater, 02118
    - Boston Medical Center
  - Boston, Massachusetts, Forente stater, 02114
    - Massachusetts General Hospital Cancer Center
  - Brighton, Massachusetts, Forente stater, 02135
    - Steward Saint Elizabeth's Medical Center
  - Burlington, Massachusetts, Forente stater, 01805
    - Lahey Hospital and Medical Center
  - Concord, Massachusetts, Forente stater, 01742
    - Commonwealth Hematology Oncology PC-Concord
  - Danvers, Massachusetts, Forente stater, 01923
    - Mass General/North Shore Cancer Center
  - Fitchburg, Massachusetts, Forente stater, 01420
    - Simonds-Sinon Regional Cancer Center
  - Framingham, Massachusetts, Forente stater, 01702
    - MetroWest Medical Center-Framingham Union Hospital
  - Gloucester, Massachusetts, Forente stater, 01930
    - Addison Gilbert Hospital
  - Haverhill, Massachusetts, Forente stater, 01830
    - Dana Farber Community Cancer Care-Haverhill
  - Methuen, Massachusetts, Forente stater, 01844
    - Holy Family Hospital
  - Methuen, Massachusetts, Forente stater, 01844
    - Dana Farber-Merrimack Valley
  - Norwood, Massachusetts, Forente stater, 02062
    - Norwood Hospital
  - Pittsfield, Massachusetts, Forente stater, 01201
    - Berkshire Medical Center - Cancer Center
  - Quincy, Massachusetts, Forente stater, 02169
    - Dana Farber Community Cancer Care-Quincy
  - Springfield, Massachusetts, Forente stater, 01199
    - Baystate Medical Center
  - Stoneham, Massachusetts, Forente stater, 02180
    - Dana Farber Community Cancer Care-Stoneham
  - Westfield, Massachusetts, Forente stater, 01085
    - Noble Hospital
  - Weymouth, Massachusetts, Forente stater, 02189
    - Dana Farber Community Cancer Care-Weymouth
  - Worcester, Massachusetts, Forente stater, 01655
    - UMass Memorial Medical Center - University Campus
  - Worcester, Massachusetts, Forente stater, 01605
    - Commonwealth Hematology Oncology PC-Worcester
- Michigan
  - Adrian, Michigan, Forente stater, 49221
    - Bixby Medical Center
  - Adrian, Michigan, Forente stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forente stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, Forente stater, 48106
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forente stater, 48106
    - Michigan Cancer Research Consortium NCORP
  - Battle Creek, Michigan, Forente stater, 49017
    - Bronson Battle Creek
  - Bay City, Michigan, Forente stater, 48706
    - McLaren Cancer Institute-Bay City
  - Big Rapids, Michigan, Forente stater, 49307
    - Spectrum Health Big Rapids Hospital
  - Clarkston, Michigan, Forente stater, 48346
    - McLaren Cancer Institute-Clarkston
  - Dearborn, Michigan, Forente stater, 48124
    - Beaumont Hospital - Dearborn
  - Detroit, Michigan, Forente stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forente stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Forente stater, 48236
    - Ascension Saint John Hospital
  - East Lansing, Michigan, Forente stater, 48824
    - Michigan State University Clinical Center
  - Escanaba, Michigan, Forente stater, 49829
    - Green Bay Oncology - Escanaba
  - Farmington Hills, Michigan, Forente stater, 48336
    - Beaumont Hospital - Farmington Hills
  - Flint, Michigan, Forente stater, 48532
    - Genesys Regional Medical Center-West Flint Campus
  - Flint, Michigan, Forente stater, 48532
    - McLaren Cancer Institute-Flint
  - Flint, Michigan, Forente stater, 48532
    - Singh and Arora Hematology Oncology PC
  - Flint, Michigan, Forente stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forente stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forente stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forente stater, 49503
    - Cancer Research Consortium of West Michigan NCORP
  - Grand Rapids, Michigan, Forente stater, 49503
    - Trinity Health Grand Rapids Hospital
  - Holland, Michigan, Forente stater, 49423
    - Holland Community Hospital
  - Iron Mountain, Michigan, Forente stater, 49801
    - Green Bay Oncology - Iron Mountain
  - Jackson, Michigan, Forente stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forente stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forente stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forente stater, 49048
    - Borgess Medical Center
  - Lansing, Michigan, Forente stater, 48910
    - Karmanos Cancer Institute at McLaren Greater Lansing
  - Lansing, Michigan, Forente stater, 48912
    - University of Michigan Health - Sparrow Lansing
  - Lapeer, Michigan, Forente stater, 48446
    - McLaren Cancer Institute-Lapeer Region
  - Lapeer, Michigan, Forente stater, 48446
    - Lapeer Regional Hospital
  - Livonia, Michigan, Forente stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Marquette, Michigan, Forente stater, 49855
    - UP Health System Marquette
  - Midland, Michigan, Forente stater, 48670
    - MyMichigan Medical Center Midland
  - Monroe, Michigan, Forente stater, 48162
    - Mercy Memorial Hospital
  - Monroe, Michigan, Forente stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Mount Clemens, Michigan, Forente stater, 48043
    - McLaren Cancer Institute-Macomb
  - Muskegon, Michigan, Forente stater, 49442
    - Mercy Health Partners-Hackley Campus
  - Muskegon, Michigan, Forente stater, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, Forente stater, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Petoskey, Michigan, Forente stater, 49770
    - McLaren Cancer Institute-Northern Michigan
  - Pontiac, Michigan, Forente stater, 48341
    - Saint Joseph Mercy Oakland
  - Port Huron, Michigan, Forente stater, 48060
    - Lake Huron Medical Center
  - Reed City, Michigan, Forente stater, 49677
    - Corewell Health Reed City Hospital
  - Royal Oak, Michigan, Forente stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Saginaw, Michigan, Forente stater, 48601
    - Ascension Saint Mary's Hospital
  - Saint Joseph, Michigan, Forente stater, 49085
    - Lakeland Medical Center Saint Joseph
  - Saint Joseph, Michigan, Forente stater, 49085
    - Oncology Care Associates PLLC
  - Saint Joseph, Michigan, Forente stater, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Southfield, Michigan, Forente stater, 48075
    - Ascension Providence Hospitals - Southfield
  - Traverse City, Michigan, Forente stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forente stater, 48085
    - William Beaumont Hospital - Troy
  - Warren, Michigan, Forente stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Wyoming, Michigan, Forente stater, 49519
    - University of Michigan Health - West
- Minnesota
  - Alexandria, Minnesota, Forente stater, 56308
    - Medini, Eitan MD (UIA Investigator)
  - Bemidji, Minnesota, Forente stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, Forente stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forente stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forente stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forente stater, 55805
    - Saint Luke's Hospital of Duluth
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forente stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forente stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forente stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fergus Falls, Minnesota, Forente stater, 56537
    - Etzell, Paul S MD (UIA Investigator)
  - Fergus Falls, Minnesota, Forente stater, 56537
    - Swenson, Wade II, MD (UIA Investigator)
  - Fridley, Minnesota, Forente stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forente stater, 55350
    - Hutchinson Area Health Care
  - Litchfield, Minnesota, Forente stater, 55355
    - Meeker County Memorial Hospital
  - Maplewood, Minnesota, Forente stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forente stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forente stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forente stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forente stater, 55455
    - University of Minnesota/Masonic Cancer Center
  - Minneapolis, Minnesota, Forente stater, 55407
    - Virginia Piper Cancer Institute
  - Minneapolis, Minnesota, Forente stater, 55417
    - Minneapolis VA Medical Center
  - New Ulm, Minnesota, Forente stater, 56073
    - New Ulm Medical Center
  - Robbinsdale, Minnesota, Forente stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forente stater, 55905
    - Mayo Clinic in Rochester
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Metro Minnesota Community Oncology Research Consortium
  - Saint Paul, Minnesota, Forente stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forente stater, 55102
    - United Hospital
  - Saint Paul, Minnesota, Forente stater, 55102
    - Saint Joseph's Hospital - Healtheast
  - Shakopee, Minnesota, Forente stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forente stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forente stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forente stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forente stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Woodbury, Minnesota, Forente stater, 55125
    - Woodwinds Health Campus
- Mississippi
  - Hattiesburg, Mississippi, Forente stater, 39401
    - Hattiesburg Clinic - Hematology/Oncology Clinic
  - Jackson, Mississippi, Forente stater, 39216
    - University of Mississippi Medical Center
  - Jackson, Mississippi, Forente stater, 39216
    - Veterans Affairs Medical Center
  - Keesler Air Force Base, Mississippi, Forente stater, 39534
    - Keesler Medical Center
  - Pascagoula, Mississippi, Forente stater, 39581
    - Singing River Hospital
- Missouri
  - Bolivar, Missouri, Forente stater, 65613
    - Central Care Cancer Center - Bolivar
  - Branson, Missouri, Forente stater, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Southeast Cancer Center
  - Cape Girardeau, Missouri, Forente stater, 63701
    - Southeast Missouri Hospital
  - Chesterfield, Missouri, Forente stater, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, Forente stater, 65201
    - Veterans Administration
  - Columbia, Missouri, Forente stater, 65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Independence, Missouri, Forente stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forente stater, 65109
    - Capital Region Southwest Campus
  - Jefferson City, Missouri, Forente stater, 65101
    - Capital Region Medical Center
  - Joplin, Missouri, Forente stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forente stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forente stater, 64128
    - Kansas City Veterans Affairs Medical Center
  - Kansas City, Missouri, Forente stater, 64154
    - University of Kansas Cancer Center - North
  - Kansas City, Missouri, Forente stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forente stater, 64131
    - The University of Kansas Cancer Center-South
  - Kansas City, Missouri, Forente stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forente stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forente stater, 64108
    - Truman Medical Centers
  - Kansas City, Missouri, Forente stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Kansas City, Missouri, Forente stater, 64114
    - Saint Joseph Health Center
  - Lee's Summit, Missouri, Forente stater, 64064
    - University of Kansas Cancer Center - Lee's Summit
  - Lee's Summit, Missouri, Forente stater, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Forente stater, 64068
    - Liberty Radiation Oncology Center
  - Rolla, Missouri, Forente stater, 65401
    - Delbert Day Cancer Institute at PCRMC
  - Rolla, Missouri, Forente stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forente stater, 64506
    - Heartland Regional Medical Center
  - Saint Joseph, Missouri, Forente stater, 64507
    - Saint Joseph Oncology Inc
  - Saint Louis, Missouri, Forente stater, 63110
    - Washington University School of Medicine
  - Saint Louis, Missouri, Forente stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forente stater, 63141
    - Mercy Hospital Saint Louis
  - Saint Louis, Missouri, Forente stater, 63128
    - Mercy Hospital South
  - Saint Louis, Missouri, Forente stater, 63136
    - Siteman Cancer Center at Christian Hospital
  - Saint Louis, Missouri, Forente stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Saint Louis, Missouri, Forente stater, 63141
    - Saint Louis-Cape Girardeau CCOP
  - Saint Louis, Missouri, Forente stater, 63141
    - Center for Cancer Care and Research
  - Saint Louis, Missouri, Forente stater, 63141
    - Comprehensive Cancer Care PC
  - Springfield, Missouri, Forente stater, 65804
    - Cancer Research for the Ozarks NCORP
  - Springfield, Missouri, Forente stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forente stater, 65804
    - Mercy Hospital Springfield
- Montana
  - Billings, Montana, Forente stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forente stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forente stater, 59102
    - Montana Cancer Consortium NCORP
  - Billings, Montana, Forente stater, 59101
    - Northern Rockies Radiation Oncology Center
  - Billings, Montana, Forente stater, 59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman, Montana, Forente stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forente stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forente stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forente stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Great Falls, Montana, Forente stater, 59405
    - Berdeaux, Donald MD (UIA Investigator)
  - Havre, Montana, Forente stater, 59501
    - Northern Montana Hospital
  - Helena, Montana, Forente stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forente stater, 59901
    - Kalispell Regional Medical Center
  - Kalispell, Montana, Forente stater, 59901
    - Glacier Oncology PLLC
  - Kalispell, Montana, Forente stater, 59901
    - Kalispell Medical Oncology
  - Missoula, Montana, Forente stater, 59804
    - Community Medical Hospital
  - Missoula, Montana, Forente stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forente stater, 59804
    - Guardian Oncology and Center for Wellness
  - Missoula, Montana, Forente stater, 59802
    - Montana Cancer Specialists
- Nebraska
  - Grand Island, Nebraska, Forente stater, 68803
    - CHI Health Saint Francis
  - Kearney, Nebraska, Forente stater, 68847
    - CHI Health Good Samaritan
  - Lincoln, Nebraska, Forente stater, 68510
    - Nebraska Cancer Research Center
  - North Platte, Nebraska, Forente stater, 69101
    - Great Plains Health Callahan Cancer Center
  - Omaha, Nebraska, Forente stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forente stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forente stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forente stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forente stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forente stater, 68106
    - Missouri Valley Cancer Consortium
- Nevada
  - Las Vegas, Nevada, Forente stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forente stater, 89169
    - Nevada Cancer Research Foundation NCORP
  - Las Vegas, Nevada, Forente stater, 89135
    - Nevada Cancer Institute-Summerlin Campus
  - Reno, Nevada, Forente stater, 89502
    - Renown Regional Medical Center
- New Hampshire
  - Concord, New Hampshire, Forente stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Dover, New Hampshire, Forente stater, 03820
    - Wentworth-Douglass Hospital
  - Exeter, New Hampshire, Forente stater, 03833
    - Exeter Hospital
  - Keene, New Hampshire, Forente stater, 03431
    - Cheshire Medical Center-Dartmouth-Hitchcock Keene
  - Laconia, New Hampshire, Forente stater, 03246
    - LRGHealthcare-Lakes Region General Hospital
  - Manchester, New Hampshire, Forente stater, 03103
    - Solinsky Center for Cancer Care
  - Nashua, New Hampshire, Forente stater, 03060
    - Saint Joseph Hospital
  - Nashua, New Hampshire, Forente stater, 03060
    - Foundation Medical Partners
  - Portsmouth, New Hampshire, Forente stater, 03802
    - Portsmouth Regional Hospital
- New Jersey
  - Brick, New Jersey, Forente stater, 08724
    - Ocean University Medical Center
  - Camden, New Jersey, Forente stater, 08103
    - Cooper Hospital University Medical Center
  - East Orange, New Jersey, Forente stater, 07018-1095
    - Veterans Adminstration New Jersey Health Care System
  - Englewood, New Jersey, Forente stater, 07631
    - Englewood Hospital and Medical Center
  - Flemington, New Jersey, Forente stater, 08822
    - Hunterdon Medical Center
  - Freehold, New Jersey, Forente stater, 07728
    - CentraState Medical Center
  - Hamilton, New Jersey, Forente stater, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Morristown, New Jersey, Forente stater, 07960
    - Morristown Medical Center
  - Mount Holly, New Jersey, Forente stater, 08060
    - Virtua Memorial
  - Neptune, New Jersey, Forente stater, 07753
    - Jersey Shore Medical Center
  - New Brunswick, New Jersey, Forente stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - New Brunswick, New Jersey, Forente stater, 08901
    - Saint Peter's University Hospital
  - Newark, New Jersey, Forente stater, 07112
    - Newark Beth Israel Medical Center
  - Pennington, New Jersey, Forente stater, 08534
    - Capital Health Medical Center-Hopewell
  - Phillipsburg, New Jersey, Forente stater, 08865
    - Saint Luke's Hospital-Warren Campus
  - Plainsboro, New Jersey, Forente stater, 08536
    - Penn Medicine Princeton Health
  - Pomona, New Jersey, Forente stater, 08240
    - AtlantiCare Regional Medical Center -Main Campus
  - Red Bank, New Jersey, Forente stater, 07701
    - Riverview Medical Center/Booker Cancer Center
  - Ridgewood, New Jersey, Forente stater, 07450
    - Valley Hospital
  - Somerville, New Jersey, Forente stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Sparta, New Jersey, Forente stater, 07871
    - Sparta Cancer Treatment Center
  - Summit, New Jersey, Forente stater, 07902
    - Overlook Hospital
  - Trenton, New Jersey, Forente stater, 08629
    - Saint Francis Medical Center
  - Vineland, New Jersey, Forente stater, 08360
    - Inspira Medical Center Vineland
  - Voorhees, New Jersey, Forente stater, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, Forente stater, 87102
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forente stater, 87102
    - Lovelace Medical Center-Saint Joseph Square
  - Albuquerque, New Mexico, Forente stater, 87106
    - Hematology Oncology Associates
  - Albuquerque, New Mexico, Forente stater, 87110
    - Presbyterian Kaseman Hospital
  - Las Cruces, New Mexico, Forente stater, 88011
    - Memorial Medical Center - Las Cruces
  - Las Cruces, New Mexico, Forente stater, 88011
    - Memorial Medical Center-Main Campus
  - Santa Fe, New Mexico, Forente stater, 87505
    - Christus Saint Vincent Regional Cancer Center
- New York
  - Albany, New York, Forente stater, 12206
    - New York Oncology Hematology PC - Albany
  - Albany, New York, Forente stater, 12208
    - New York Oncology Hematology PC - Albany Medical Center
  - Bronx, New York, Forente stater, 10467
    - Montefiore Medical Center - Moses Campus
  - Bronx, New York, Forente stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Brooklyn, New York, Forente stater, 11219
    - Maimonides Medical Center
  - Brooklyn, New York, Forente stater, 11203
    - Kings County Hospital
  - Brooklyn, New York, Forente stater, 11235
    - Coney Island Hospital
  - Brooklyn, New York, Forente stater, 11209
    - Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
  - Brooklyn, New York, Forente stater, 11203
    - State University of New York Downstate Medical Center
  - Buffalo, New York, Forente stater, 14215
    - Veterans Affairs Western New York Health Care System-Buffalo
  - Clifton Park, New York, Forente stater, 12065
    - New York Oncology Hematology PC - Clifton Park
  - Clifton Springs, New York, Forente stater, 14432
    - Finger Lakes Hematology and Oncology
  - Cooperstown, New York, Forente stater, 13326
    - Mary Imogene Bassett Hospital
  - East Syracuse, New York, Forente stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Elmira, New York, Forente stater, 14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - Glens Falls, New York, Forente stater, 12801
    - Glens Falls Hospital
  - Glens Falls, New York, Forente stater, 12801
    - Adirondack Cancer Center
  - Hudson, New York, Forente stater, 12534
    - New York Oncology Hematology PC-Hudson
  - Lake Success, New York, Forente stater, 11042
    - Northwell Health NCORP
  - Lake Success, New York, Forente stater, 11042
    - Northwell Health/Center for Advanced Medicine
  - Manhasset, New York, Forente stater, 11030
    - North Shore University Hospital
  - Middletown, New York, Forente stater, 10940
    - Garnet Health Medical Center
  - Mineola, New York, Forente stater, 11501
    - NYU Winthrop Hospital
  - Mount Kisco, New York, Forente stater, 10549
    - Northern Westchester Hospital
  - Mount Kisco, New York, Forente stater, 10549
    - Mount Kisco Medical Group
  - New Hyde Park, New York, Forente stater, 11040
    - Long Island Jewish Medical Center
  - New York, New York, Forente stater, 10019
    - Mount Sinai West
  - New York, New York, Forente stater, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York, New York, Forente stater, 10065
    - NYP/Weill Cornell Medical Center
  - New York, New York, Forente stater, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - New York, New York, Forente stater, 10003
    - Mount Sinai Union Square
  - Nyack, New York, Forente stater, 10960
    - Nyack Hospital
  - Poughkeepsie, New York, Forente stater, 12601
    - Vassar Brothers Medical Center
  - Poughkeepsie, New York, Forente stater, 12601
    - MidHudson Regional Hospital of Westchester Medical Center
  - Poughkeepsie, New York, Forente stater, 12601
    - Hudson Valley Hematology Oncology Associates
  - Poughkeepsie, New York, Forente stater, 12601
    - The Dyson Center for Cancer Care
  - Rochester, New York, Forente stater, 14642
    - University of Rochester
  - Rochester, New York, Forente stater, 14620
    - Highland Hospital
  - Rochester, New York, Forente stater, 14623
    - Interlakes Foundation Inc-Rochester
  - Staten Island, New York, Forente stater, 10305
    - Staten Island University Hospital
  - Stony Brook, New York, Forente stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forente stater, 13210
    - State University of New York Upstate Medical University
  - Syracuse, New York, Forente stater, 13210
    - Syracuse Veterans Administration Medical Center
  - Troy, New York, Forente stater, 12180
    - New York Oncology Hematology PC - Troy
  - Utica, New York, Forente stater, 13502
    - Faxton-Saint Luke's Healthcare
  - White Plains, New York, Forente stater, 10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Asheboro, North Carolina, Forente stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forente stater, 28801
    - Mission Hospital
  - Burlington, North Carolina, Forente stater, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Cary, North Carolina, Forente stater, 27518
    - Waverly Hematology Oncology
  - Chapel Hill, North Carolina, Forente stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forente stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Forente stater, 28204
    - Novant Health Presbyterian Medical Center
  - Concord, North Carolina, Forente stater, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Durham, North Carolina, Forente stater, 27705
    - Durham VA Medical Center
  - Goldsboro, North Carolina, Forente stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forente stater, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Forente stater, 27403
    - Cone Health Cancer Center
  - Hendersonville, North Carolina, Forente stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville, North Carolina, Forente stater, 28792
    - AdventHealth Hendersonville
  - Kinston, North Carolina, Forente stater, 28501
    - Vidant Oncology-Kinston
  - Monroe, North Carolina, Forente stater, 28112
    - Atrium Health Union/LCI-Union
  - Pinehurst, North Carolina, Forente stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh, North Carolina, Forente stater, 27607
    - UNC Rex Healthcare
  - Reidsville, North Carolina, Forente stater, 27320
    - Annie Penn Memorial Hospital
  - Rutherfordton, North Carolina, Forente stater, 28139
    - Rutherford Hospital
  - Shelby, North Carolina, Forente stater, 28150
    - Atrium Health Cleveland/LCI-Cleveland
  - Statesville, North Carolina, Forente stater, 28677
    - Iredell Memorial Hospital
  - Washington, North Carolina, Forente stater, 27889
    - Marion L Shepard Cancer Center at Vidant Beaufort Hospital
  - Winston-Salem, North Carolina, Forente stater, 27103
    - Novant Health Forsyth Medical Center
  - Winston-Salem, North Carolina, Forente stater, 27104
    - Southeast Clinical Oncology Research Consortium NCORP
- North Dakota
  - Bismarck, North Dakota, Forente stater, 58501
    - Sanford Bismarck Medical Center
  - Bismarck, North Dakota, Forente stater, 58501
    - Mid Dakota Clinic
  - Bismarck, North Dakota, Forente stater, 58501
    - Saint Alexius Medical Center
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Clinic North-Fargo
  - Fargo, North Dakota, Forente stater, 58102
    - Veterans Administration Medical Center
  - Grand Forks, North Dakota, Forente stater, 58201
    - Altru Cancer Center
- Ohio
  - Akron, Ohio, Forente stater, 44307
    - Cleveland Clinic Akron General
  - Akron, Ohio, Forente stater, 44304
    - Summa Health System - Akron Campus
  - Barberton, Ohio, Forente stater, 44203
    - Summa Health System - Barberton Campus
  - Beachwood, Ohio, Forente stater, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Beachwood, Ohio, Forente stater, 44122
    - Cleveland Clinic Cancer Center Beachwood
  - Bellefontaine, Ohio, Forente stater, 43311
    - Mary Rutan Hospital
  - Bowling Green, Ohio, Forente stater, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Canton, Ohio, Forente stater, 44708
    - Cleveland Clinic Mercy Hospital
  - Canton, Ohio, Forente stater, 44710
    - Aultman Health Foundation
  - Chardon, Ohio, Forente stater, 44024
    - Geauga Hospital
  - Chillicothe, Ohio, Forente stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forente stater, 45219
    - The Christ Hospital
  - Cincinnati, Ohio, Forente stater, 45219
    - University of Cincinnati Cancer Center-UC Medical Center
  - Cleveland, Ohio, Forente stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forente stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forente stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forente stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Clyde, Ohio, Forente stater, 43410
    - North Coast Cancer Care-Clyde
  - Columbus, Ohio, Forente stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forente stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forente stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forente stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forente stater, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Forente stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forente stater, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Forente stater, 43215
    - Columbus NCI Community Oncology Research Program
  - Dayton, Ohio, Forente stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forente stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forente stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forente stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forente stater, 45459
    - Dayton NCI Community Oncology Research Program
  - Dayton, Ohio, Forente stater, 45428
    - Dayton Veterans Affairs Medical Center
  - Delaware, Ohio, Forente stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forente stater, 44035
    - Mercy Cancer Center-Elyria
  - Elyria, Ohio, Forente stater, 44035
    - Hematology Oncology Center Incorporated
  - Findlay, Ohio, Forente stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forente stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Fremont, Ohio, Forente stater, 43420
    - Fremont Memorial Hospital
  - Greenville, Ohio, Forente stater, 45331
    - Wayne Hospital
  - Independence, Ohio, Forente stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kettering, Ohio, Forente stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forente stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forente stater, 45801
    - Saint Rita's Medical Center
  - Lima, Ohio, Forente stater, 45804
    - Lima Memorial Hospital
  - Mansfield, Ohio, Forente stater, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Forente stater, 45750
    - Marietta Memorial Hospital
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Maumee, Ohio, Forente stater, 43537
    - Saint Luke's Hospital
  - Mayfield Heights, Ohio, Forente stater, 44124
    - Hillcrest Hospital Cancer Center
  - Mentor, Ohio, Forente stater, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Middleburg Heights, Ohio, Forente stater, 44130
    - UH Seidman Cancer Center at Southwest General Hospital
  - Mount Vernon, Ohio, Forente stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forente stater, 43055
    - Licking Memorial Hospital
  - Norwalk, Ohio, Forente stater, 44857
    - Fisher-Titus Medical Center
  - Oregon, Ohio, Forente stater, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Forente stater, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Parma, Ohio, Forente stater, 44129
    - University Hospitals Parma Medical Center
  - Portsmouth, Ohio, Forente stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forente stater, 44870
    - North Coast Cancer Care
  - Sandusky, Ohio, Forente stater, 44870
    - UH Seidman Cancer Center at Firelands Regional Medical Center
  - Sandusky, Ohio, Forente stater, 44870
    - Firelands Regional Medical Center
  - Springfield, Ohio, Forente stater, 45505
    - Springfield Regional Medical Center
  - Steubenville, Ohio, Forente stater, 43952
    - Trinity's Tony Teramana Cancer Center
  - Strongsville, Ohio, Forente stater, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Sylvania, Ohio, Forente stater, 43560
    - ProMedica Flower Hospital
  - Tiffin, Ohio, Forente stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forente stater, 43606
    - ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
  - Toledo, Ohio, Forente stater, 43608
    - Saint Vincent Mercy Medical Center
  - Toledo, Ohio, Forente stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forente stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forente stater, 43614
    - University of Toledo
  - Toledo, Ohio, Forente stater, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Troy, Ohio, Forente stater, 45373
    - Upper Valley Medical Center
  - Wauseon, Ohio, Forente stater, 43567
    - Fulton County Health Center
  - Westerville, Ohio, Forente stater, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Forente stater, 44145
    - UHHS-Westlake Medical Center
  - Wilmington, Ohio, Forente stater, 45177
    - Clinton Memorial Hospital
  - Wooster, Ohio, Forente stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wright-Patterson Air Force Base, Ohio, Forente stater, 45433
    - Wright-Patterson Medical Center
  - Xenia, Ohio, Forente stater, 45385
    - Greene Memorial Hospital
  - Youngstown, Ohio, Forente stater, 44501
    - Forum Health Cancer Care Center
  - Zanesville, Ohio, Forente stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forente stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Norman, Oklahoma, Forente stater, 73071
    - Cancer Care Associates-Norman
  - Oklahoma City, Oklahoma, Forente stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forente stater, 73120
    - Mercy Hospital Oklahoma City
  - Oklahoma City, Oklahoma, Forente stater, 73120
    - Mercy Physicians of Oklahoma-Lakeside
  - Oklahoma City, Oklahoma, Forente stater, 73120
    - Cancer Care Associates
  - Tulsa, Oklahoma, Forente stater, 74136
    - Natalie Warren Bryant Cancer Center at Saint Francis
- Oregon
  - Bend, Oregon, Forente stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forente stater, 97015
    - Clackamas Radiation Oncology Center
  - Coos Bay, Oregon, Forente stater, 97420
    - Bay Area Hospital
  - Grants Pass, Oregon, Forente stater, 97527
    - Three Rivers Community Hospital
  - Gresham, Oregon, Forente stater, 97030
    - Legacy Mount Hood Medical Center
  - Klamath Falls, Oregon, Forente stater, 97601
    - Sky Lakes Medical Center - Cancer Treatment Center
  - Medford, Oregon, Forente stater, 97504
    - Asante Health System
  - Medford, Oregon, Forente stater, 97504
    - Providence Medford Medical Center
  - Medford, Oregon, Forente stater, 97504
    - Rogue Valley Medical Center
  - Milwaukie, Oregon, Forente stater, 97222
    - Providence Milwaukie Hospital
  - Newberg, Oregon, Forente stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forente stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forente stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forente stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forente stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forente stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forente stater, 97227
    - Kaiser Permanente Northwest
  - Portland, Oregon, Forente stater, 97227
    - Legacy Emanuel Hospital and Health Center
  - Portland, Oregon, Forente stater, 97216
    - Adventist Medical Center
  - Portland, Oregon, Forente stater, 97227
    - Compass Oncology Rose Quarter
  - Salem, Oregon, Forente stater, 97301
    - Salem Hospital
  - The Dalles, Oregon, Forente stater, 97058
    - Mid-Columbia Medical Center/Celilo Cancer Center
  - Tualatin, Oregon, Forente stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Abington, Pennsylvania, Forente stater, 19001
    - Jefferson Abington Hospital
  - Allentown, Pennsylvania, Forente stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Bethlehem, Pennsylvania, Forente stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bethlehem, Pennsylvania, Forente stater, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Bryn Mawr, Pennsylvania, Forente stater, 19010
    - Bryn Mawr Hospital
  - Butler, Pennsylvania, Forente stater, 16001
    - Butler Memorial Hospital
  - Danville, Pennsylvania, Forente stater, 17822
    - Geisinger Medical Center
  - Darby, Pennsylvania, Forente stater, 19023-1291
    - Mercy Fitzgerald Hospital
  - Doylestown, Pennsylvania, Forente stater, 18901
    - Doylestown Hospital
  - Drexel Hill, Pennsylvania, Forente stater, 19026
    - Delaware County Memorial Hospital
  - DuBois, Pennsylvania, Forente stater, 15801
    - Oncology Hematology Associates of Northern Pennsylvania
  - East Stroudsburg, Pennsylvania, Forente stater, 18301
    - Pocono Medical Center
  - Easton, Pennsylvania, Forente stater, 18042
    - Easton Hospital
  - Ephrata, Pennsylvania, Forente stater, 17522
    - Ephrata Cancer Center
  - Erie, Pennsylvania, Forente stater, 16505
    - UPMC Hillman Cancer Center Erie
  - Erie, Pennsylvania, Forente stater, 16550
    - UPMC Hamot
  - Gettysburg, Pennsylvania, Forente stater, 17325
    - Adams Cancer Center
  - Hanover, Pennsylvania, Forente stater, 17331
    - Cherry Tree Cancer Center
  - Harrisburg, Pennsylvania, Forente stater, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Hazleton, Pennsylvania, Forente stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Forente stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Lancaster, Pennsylvania, Forente stater, 17602
    - Lancaster General Hospital
  - Langhorne, Pennsylvania, Forente stater, 19047
    - Saint Mary Medical and Regional Cancer Center
  - Lemoyne, Pennsylvania, Forente stater, 17043
    - Central PA Hematology-Medical Oncology Associates PC
  - Lewistown, Pennsylvania, Forente stater, 17044
    - Lewistown Hospital
  - Meadowbrook, Pennsylvania, Forente stater, 19046
    - Holy Redeemer Hospital and Medical Center
  - Media, Pennsylvania, Forente stater, 19063
    - Riddle Memorial Hospital
  - Monroeville, Pennsylvania, Forente stater, 15146
    - Forbes Hospital
  - Natrona Heights, Pennsylvania, Forente stater, 15065
    - Allegheny Valley Hospital
  - Paoli, Pennsylvania, Forente stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forente stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forente stater, 19141
    - Einstein Medical Center Philadelphia
  - Philadelphia, Pennsylvania, Forente stater, 19107
    - Pennsylvania Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19143
    - Mercy Hospital of Philadelphia
  - Philadelphia, Pennsylvania, Forente stater, 19118
    - Chestnut Hill Health System
  - Pittsburgh, Pennsylvania, Forente stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pittsburgh, Pennsylvania, Forente stater, 15240
    - VA Pittsburgh Healthcare System
  - Pottstown, Pennsylvania, Forente stater, 19464
    - Pottstown Hospital
  - Reading, Pennsylvania, Forente stater, 19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre, Pennsylvania, Forente stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton, Pennsylvania, Forente stater, 18510
    - Scranton Hematology Oncology
  - Scranton, Pennsylvania, Forente stater, 18501
    - Mercy Hospital
  - Scranton, Pennsylvania, Forente stater, 18508
    - Hematology and Oncology Associates of North East Pennsylvania
  - Sellersville, Pennsylvania, Forente stater, 18960
    - Grand View Hospital
  - State College, Pennsylvania, Forente stater, 16801
    - Geisinger Medical Group
  - State College, Pennsylvania, Forente stater, 16803
    - Mount Nittany Medical Center
  - Upland, Pennsylvania, Forente stater, 19013
    - Associates In Hematology Oncology PC-Upland
  - West Reading, Pennsylvania, Forente stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forente stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Wilkes-Barre, Pennsylvania, Forente stater, 18765
    - Geisinger South Wilkes-Barre
  - Williamsport, Pennsylvania, Forente stater, 17701
    - UPMC Susquehanna
  - Wynnewood, Pennsylvania, Forente stater, 19096
    - Lankenau Medical Center
  - Wynnewood, Pennsylvania, Forente stater, 19096
    - Main Line Health NCORP
  - York, Pennsylvania, Forente stater, 17403
    - WellSpan Health-York Hospital
- Rhode Island
  - Cranston, Rhode Island, Forente stater, 02920
    - Hematology and Oncology Associates of Rhode Island Inc
  - Pawtucket, Rhode Island, Forente stater, 02860
    - Memorial Hospital of Rhode Island
  - Providence, Rhode Island, Forente stater, 02903
    - Rhode Island Hospital
  - Providence, Rhode Island, Forente stater, 02906
    - Miriam Hospital
  - Warwick, Rhode Island, Forente stater, 02886
    - Kent Hospital
- South Carolina
  - Anderson, South Carolina, Forente stater, 29621
    - AnMed Health Cancer Center
  - Anderson, South Carolina, Forente stater, 29621
    - AnMed Health Hospital
  - Boiling Springs, South Carolina, Forente stater, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Charleston, South Carolina, Forente stater, 29425
    - Medical University of South Carolina
  - Charleston, South Carolina, Forente stater, 29401
    - Roper Hospital
  - Easley, South Carolina, Forente stater, 29640
    - Prisma Health Cancer Institute - Easley
  - Florence, South Carolina, Forente stater, 29506
    - McLeod Regional Medical Center
  - Greenville, South Carolina, Forente stater, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Forente stater, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Forente stater, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Forente stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forente stater, 29605
    - Prisma Health Greenville Memorial Hospital
  - Greenville, South Carolina, Forente stater, 29601
    - Greenville Health System Cancer Institute-Andrews
  - Greenwood, South Carolina, Forente stater, 29646
    - Self Regional Healthcare
  - Greer, South Carolina, Forente stater, 29650
    - Prisma Health Cancer Institute - Greer
  - Rock Hill, South Carolina, Forente stater, 29732
    - Levine Cancer Institute-Rock Hill
  - Seneca, South Carolina, Forente stater, 29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg, South Carolina, Forente stater, 29303
    - Spartanburg Medical Center
- South Dakota
  - Aberdeen, South Dakota, Forente stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Rapid City, South Dakota, Forente stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forente stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forente stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forente stater, 57104
    - Sanford Cancer Center Oncology Clinic
  - Sioux Falls, South Dakota, Forente stater, 57105
    - Medical X-Ray Center
  - Sioux Falls, South Dakota, Forente stater, 57117-5045
    - Avera McKennan Hospital and University Health Center
- Tennessee
  - Bristol, Tennessee, Forente stater, 37620
    - Wellmont Medical Associates Oncology and Hematology-Bristol
  - Chattanooga, Tennessee, Forente stater, 37403
    - Erlanger Medical Center
  - Franklin, Tennessee, Forente stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Germantown, Tennessee, Forente stater, 38138
    - Jones Clinic
  - Jackson, Tennessee, Forente stater, 38301
    - Jackson-Madison County General Hospital
  - Kingsport, Tennessee, Forente stater, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Knoxville, Tennessee, Forente stater, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, Forente stater, 37920
    - University of Tennessee - Knoxville
  - Memphis, Tennessee, Forente stater, 38163
    - University of Tennessee Health Science Center
  - Nashville, Tennessee, Forente stater, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Forente stater, 37208
    - Meharry Medical College
  - Nashville, Tennessee, Forente stater, 37203
    - Nashville Oncology Associates PC
- Texas
  - Amarillo, Texas, Forente stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - Dallas, Texas, Forente stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forente stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Dallas, Texas, Forente stater, 75230
    - Medical City Dallas Hospital
  - Dallas, Texas, Forente stater, 75246
    - Baylor University Medical Center
  - Dallas, Texas, Forente stater, 75216
    - Dallas VA Medical Center
  - Dallas, Texas, Forente stater, 75390
    - Clements University Hospital
  - Dallas, Texas, Forente stater, 75231
    - Texas Health Presbyterian Hospital Dallas
  - Fort Sam Houston, Texas, Forente stater, 78234
    - Brooke Army Medical Center
  - Lackland Air Force Base, Texas, Forente stater, 78236
    - Wilford Hall Medical Center
  - Lubbock, Texas, Forente stater, 79430
    - Texas Tech University Health Sciences Center-Lubbock
  - San Antonio, Texas, Forente stater, 78229
    - University Hospital
  - San Antonio, Texas, Forente stater, 78229
    - University of Texas Health Science Center at San Antonio
  - San Antonio, Texas, Forente stater, 78229
    - Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
  - San Antonio, Texas, Forente stater, 78229
    - Audie L Murphy VA Hospital
  - Temple, Texas, Forente stater, 76508
    - Scott and White Memorial Hospital
- Utah
  - Salt Lake City, Utah, Forente stater, 84112
    - Huntsman Cancer Institute/University of Utah
- Vermont
  - Bennington, Vermont, Forente stater, 05201
    - Southwestern Vermont Medical Center
  - Berlin, Vermont, Forente stater, 05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington, Vermont, Forente stater, 05405
    - University of Vermont and State Agricultural College
- Virginia
  - Charlottesville, Virginia, Forente stater, 22908
    - University of Virginia Cancer Center
  - Charlottesville, Virginia, Forente stater, 22901
    - Sentara Martha Jefferson Hospital
  - Danville, Virginia, Forente stater, 24541
    - Danville Regional Medical Center
  - Fredericksburg, Virginia, Forente stater, 22401
    - Fredericksburg Oncology Inc
  - Fredericksburg, Virginia, Forente stater, 22408
    - Hematology Oncology Associates of Fredericksburg Inc
  - Hampton, Virginia, Forente stater, 23666
    - Virginia Oncology Associates-Hampton
  - Lynchburg, Virginia, Forente stater, 24501
    - Centra Lynchburg Hematology-Oncology Clinic Inc
  - Martinsville, Virginia, Forente stater, 24115
    - Sovah Health Martinsville
  - Norton, Virginia, Forente stater, 24273
    - Southwest VA Regional Cancer Center
  - Richmond, Virginia, Forente stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forente stater, 23249
    - Hunter Holmes McGuire Veterans Administration Medical Center
- Washington
  - Anacortes, Washington, Forente stater, 98221
    - Cancer Care Center at Island Hospital
  - Auburn, Washington, Forente stater, 98001
    - MultiCare Auburn Medical Center
  - Bellevue, Washington, Forente stater, 98004
    - Overlake Medical Center
  - Bellingham, Washington, Forente stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forente stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Burien, Washington, Forente stater, 98166
    - Highline Medical Center-Main Campus
  - Centralia, Washington, Forente stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forente stater, 98026
    - Swedish Cancer Institute-Edmonds
  - Everett, Washington, Forente stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forente stater, 98003
    - Saint Francis Hospital
  - Issaquah, Washington, Forente stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forente stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kirkland, Washington, Forente stater, 98034
    - Seattle Cancer Care Alliance at EvergreenHealth
  - Kirkland, Washington, Forente stater, 98033
    - EvergreenHealth Medical Center
  - Lacey, Washington, Forente stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forente stater, 98499
    - Saint Clare Hospital
  - Mount Vernon, Washington, Forente stater, 98274
    - Skagit Valley Hospital
  - Olympia, Washington, Forente stater, 98506-5166
    - Providence - Saint Peter Hospital
  - Port Angeles, Washington, Forente stater, 98362
    - Olympic Medical Center
  - Poulsbo, Washington, Forente stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Forente stater, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, Forente stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forente stater, 98109
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, Forente stater, 98104
    - Harborview Medical Center
  - Seattle, Washington, Forente stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forente stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forente stater, 98195
    - University of Washington Medical Center - Montlake
  - Seattle, Washington, Forente stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forente stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forente stater, 98104
    - Pacific Medical Center-First Hill
  - Seattle, Washington, Forente stater, 98122
    - Pacific Cancer Research Consortium NCORP
  - Sedro-Woolley, Washington, Forente stater, 98284
    - PeaceHealth United General Medical Center
  - Spokane, Washington, Forente stater, 99218
    - Evergreen Hematology and Oncology PS
  - Spokane, Washington, Forente stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forente stater, 99220
    - Rockwood Clinic
  - Tacoma, Washington, Forente stater, 98431
    - Madigan Army Medical Center
  - Tacoma, Washington, Forente stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forente stater, 98405
    - MultiCare Allenmore Hospital
  - Tacoma, Washington, Forente stater, 98405
    - Northwest NCI Community Oncology Research Program
  - Tacoma, Washington, Forente stater, 98405
    - Saint Joseph Medical Center
  - Vancouver, Washington, Forente stater, 98686
    - Legacy Salmon Creek Hospital
  - Vancouver, Washington, Forente stater, 98664
    - PeaceHealth Southwest Medical Center
  - Vancouver, Washington, Forente stater, 98684
    - Compass Oncology Vancouver
  - Wenatchee, Washington, Forente stater, 98801
    - Wenatchee Valley Hospital and Clinics
- West Virginia
  - Charleston, West Virginia, Forente stater, 25304
    - West Virginia University Charleston Division
  - Huntington, West Virginia, Forente stater, 25701
    - Edwards Comprehensive Cancer Center
  - Huntington, West Virginia, Forente stater, 25702
    - Saint Mary's Medical Center
  - Morgantown, West Virginia, Forente stater, 26506
    - West Virginia University Healthcare
  - Wheeling, West Virginia, Forente stater, 26003
    - Wheeling Hospital/Schiffler Cancer Center
- Wisconsin
  - Appleton, Wisconsin, Forente stater, 54911
    - ThedaCare Regional Cancer Center
  - Burlington, Wisconsin, Forente stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Forente stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forente stater, 54701
    - HSHS Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forente stater, 54701
    - Mayo Clinic Health System-Eau Claire Clinic
  - Eau Claire, Wisconsin, Forente stater, 54703
    - Mayo Clinic Health System Eau Claire Hospital-Luther Campus
  - Eau Claire, Wisconsin, Forente stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Fond Du Lac, Wisconsin, Forente stater, 54935
    - Saint Agnes Hospital/Agnesian Cancer Center
  - Franklin, Wisconsin, Forente stater, 53132
    - Aurora Cancer Care-Franklin
  - Germantown, Wisconsin, Forente stater, 53022
    - Aurora Health Care Germantown Health Center
  - Glendale, Wisconsin, Forente stater, 53212
    - Aurora Cancer Care-Glendale
  - Green Bay, Wisconsin, Forente stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forente stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forente stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forente stater, 54301
    - Bellin Memorial Hospital
  - Green Bay, Wisconsin, Forente stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forente stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Janesville, Wisconsin, Forente stater, 53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Johnson Creek, Wisconsin, Forente stater, 53038
    - UW Cancer Center Johnson Creek
  - Kenosha, Wisconsin, Forente stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forente stater, 54601
    - Gundersen Lutheran Medical Center
  - La Crosse, Wisconsin, Forente stater, 54601
    - Mayo Clinic Health System-Franciscan Healthcare
  - Madison, Wisconsin, Forente stater, 53717
    - Dean Hematology and Oncology Clinic
  - Madison, Wisconsin, Forente stater, 53792
    - University of Wisconsin Carbone Cancer Center
  - Manitowoc, Wisconsin, Forente stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forente stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, Forente stater, 54143
    - Bay Area Medical Center
  - Marshfield, Wisconsin, Forente stater, 54449
    - Marshfield Medical Center-Marshfield
  - Marshfield, Wisconsin, Forente stater, 54449
    - Marshfield Medical Center
  - Mequon, Wisconsin, Forente stater, 53097
    - Ascension Columbia Saint Mary's Hospital Ozaukee
  - Milwaukee, Wisconsin, Forente stater, 53226
    - Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forente stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53233
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53210
    - Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
  - Milwaukee, Wisconsin, Forente stater, 53211
    - Ascension Columbia Saint Mary's Hospital - Milwaukee
  - Minocqua, Wisconsin, Forente stater, 54548
    - Marshfield Clinic-Minocqua Center
  - New Richmond, Wisconsin, Forente stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconto Falls, Wisconsin, Forente stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forente stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forente stater, 53406
    - Aurora Cancer Care-Racine
  - Racine, Wisconsin, Forente stater, 53405
    - Ascension All Saints Hospital
  - Rhinelander, Wisconsin, Forente stater, 54501
    - Ascension Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forente stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forente stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Forente stater, 53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Forente stater, 54481
    - Ascension Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forente stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Summit, Wisconsin, Forente stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forente stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forente stater, 53188
    - Aurora Cancer Care-Waukesha
  - Wausau, Wisconsin, Forente stater, 54401
    - Aspirus Regional Cancer Center
  - Wausau, Wisconsin, Forente stater, 54401
    - Marshfield Clinic-Wausau Center
  - Wauwatosa, Wisconsin, Forente stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - Weston, Wisconsin, Forente stater, 54476
    - Marshfield Medical Center - Weston
  - Weston, Wisconsin, Forente stater, 54476
    - Diagnostic and Treatment Center
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Casper, Wyoming, Forente stater, 82609
    - Rocky Mountain Oncology
  - Sheridan, Wyoming, Forente stater, 82801
    - Welch Cancer Center
Irland
- - Cork, Irland
    - Cork University Hospital
  - Dublin, Irland, 8
    - Saint James Hospital
- Co Dublin
  - Dublin, Co Dublin, Irland, 24
    - Tallaght University Hospital
  - Dublin, Co Dublin, Irland, 4
    - Saint Vincent's University Hospital
  - Dublin, Co Dublin, Irland, 7
    - Mater Misericordiae University Hospital
  - Dublin, Co Dublin, Irland, 7
    - Mater Private Hospital
  - Dublin, Co Dublin, Irland, 9
    - Beaumont Hospital
- Co Galway
  - Galway, Co Galway, Irland
    - University College Hospital Galway
- Co Limerick
  - Limerick, Co Limerick, Irland, 9
    - Mid-Western Regional Hospital
- Co Waterford
  - Waterford, Co Waterford, Irland, 9
    - University Hospital Waterford
Peru
- - Lima, Peru, Lima 34
    - Instituto Nacional de Enfermedades Neoplasicas
Sør-Afrika
- - Pretoria, Sør-Afrika, 0002
    - University Of Pretoria

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Beskrivelse

Inklusjonskriterier:

For å være kvalifisert for denne studien, må pasienter ha gjennomgått fullstendig reseksjon av sin ikke-småcellet lungekreft (NSCLC) [stadium IB (>= 4 cm)] - [IIIA (T2-3N0, T1-3N1, T1- 3N2] før påmelding; aksepterte typer reseksjon vil bestå av lobektomi, ermet lobektomi, bi-lobektomi eller pneumonektomi; reseksjoner ved segmentektomi eller kilereseksjon vil ikke bli akseptert; mediastinal lymfeknuteprøve på spesifiserte nivåer er nødvendig preoperativt) (mediastinoskopi) eller intraoperativt (nivå 7 og 4 for høyresidige svulster eller nivå 7 og 5 og/eller 6 for venstresidige svulster)
Pasienter må være minst 6 uker (42 dager) og ikke mer enn 12 uker (84 dager) etter torakotomi på tidspunktet for randomisering og må være tilstrekkelig restituert etter operasjonen
Eastern Cooperative Oncology Group (ECOG) ytelsesstatus 0 eller 1
Pasienter skal ikke ha mottatt følgende:
- Tidligere systemisk kjemoterapi til enhver tid; metotreksat (MTX) gitt i lave doser for ikke-maligne tilstander med siste dose minst 2 uker før registreringsdatoen er tillatt; andre lavdose kjemoterapeutika for ikke-maligne tilstander vil bli vurdert, men gjennomgang av studielederen er nødvendig
- Hormonell kreftbehandling eller strålebehandling som tidligere kreftbehandling innen 5 år etter randomisering; (tidligere kirurgi, biologisk terapi, hormonbehandling eller strålebehandling for en malignitet over 5 år før påmelding som nå anses som helbredet er akseptabelt)
Pasienter må ikke ha noen krefthistorie innen 5 år fra randomisering, med unntak av in-situ karsinom i livmorhalsen eller fullstendig resekert ikke-melanom hudkreft
Absolutt nøytrofiltall (ANC) >= 1500 mm^3
Blodplater >= 100 000/mm^3
Protrombintid/internasjonalt normalisert forhold (INR) =< 1,5
- Eller, hvis pasienten er på terapeutisk antikoagulasjon, protrombintid/INR =< 3,0
Partiell tromboplastintid (PTT) =< institusjonell øvre normalgrense (ULN) ELLER, hvis pasienten er på terapeutisk antikoagulasjon, må PTT være =< 1,5 x ULN
Total bilirubin =< 1,5 mg/dL
Serumglutaminoksaloeddiksyretransaminase (SGOT) (aspartataminotransferase [AST]) < 5 x øvre normalgrense (ULN)
Serumglutamatpyruvattransaminase (SGPT) (alaninaminotransferase [ALT]) < 5 x øvre normalgrense (ULN)
Serumkreatinin =< 1,5 x institusjonell øvre normalgrense (ULN)
Urinprotein bør screenes ved urinanalyse for urinproteinkreatinin (UPC) ratio; for UPC-forhold > 0,5, må 24-timers urinprotein oppnås og nivået må være < 1000 mg (1 g) for pasientregistrering
Pasienter med en kjent historie med hjerteinfarkt eller andre tegn på arteriell trombotisk sykdom (angina) vil kun få delta i studien hvis de ikke har hatt tegn på aktiv sykdom i minst 12 måneder før randomisering
Pasienter med noen historie med cerebral vaskulær ulykke (CVA) eller forbigående iskemisk angrep (TIA) vil ikke bli tillatt på prøve
Kvinner må ikke være gravide eller ammende
- Alle kvinner i fertil alder må ha en blod- eller urinprøve innen 2 uker før randomisering for å utelukke graviditet
Både fertile menn og kvinner må godta å bruke adekvate prevensjonstiltak under studiebehandlingen og i minst 6 måneder etter fullføring av bevacizumab
Pasienter må ikke ha noen klinisk signifikant pågående, aktiv eller alvorlig infeksjon, symptomatisk eller ukontrollert kongestiv hjertesvikt, symptomatisk eller ukontrollert hjertearytmi eller noen annen medisinsk tilstand eller psykiatrisk sykdom/sosiale situasjoner som vil begrense overholdelse av studiekravene
Pasienter må ikke ha noen historie med blødende diatese eller koagulopati
Alle pasienter skal ha et dokumentert blodtrykk (BP) med systolisk =< 150 og diastolisk =< 90 innen 28 dager etter registrering; Pasienter med kjent hypertensjon må ha et stabilt regime med antihypertensiv behandling
Pasienter som mottar daglig behandling med aspirin eller ikke-steroide antiinflammatoriske midler (NSAIDS) er kvalifisert; behandling med dipyridamol (Persantine), tiklopin (Ticlid), klopidogrel (Plavix) og/eller cilostazol (Pletal) er ikke tillatt; Pasienter må ha sluttet å ta noen av disse midlene minst 7 dager før randomisering
Pasienter må ikke ha alvorlige ikke-helende sår, magesår, benbrudd eller ha gjennomgått en større kirurgisk prosedyre, åpen biopsi eller betydelig traumatisk skade innen 28 dager før randomisering ELLER kjernebiopsi innen 7 dager før randomisering
Pasienter må ikke ha en historie med abdominal fistel, gastrointestinal perforasjon eller intraabdominal abscess innen 28 dager før randomisering
Pasienter må ikke ha noen forventet større kirurgisk(e) prosedyre(r) i løpet av studien
Pasienter må ikke ha kjent overfølsomhet overfor eggstokkcelleprodukter fra kinesisk hamster eller andre rekombinante humane antistoffer
Pasienter kan være på et stabilt kur med terapeutisk antikoagulasjon eller kan motta profylaktisk antikoagulasjon av venøs tilgangsutstyr, forutsatt at koagulasjonsstudier oppfyller inngangskriteriene ovenfor; forsiktighet må utvises for pasienter som trenger antikoagulasjon, inkludert behandling med lavdose heparin eller lavmolekylært heparin for dyp venetrombose (DVT) profylakse under studien
Pasienter med pågående postoperativ hemoptyse (definert som knallrødt blod på 1/2 teskje eller mer) er ikke kvalifisert; Pasienter med preoperativ hemoptyse som har forsvunnet postoperativt er kvalifisert
Pasienter som skal få behandling med pemetrexed (pemetrexed dinatrium)/cisplatin må også oppfylle følgende kriterier:
- Pasienter som får pemetrexed/cisplatinbehandling må IKKE ha plateepitelhistologi
- Beregnet kreatininclearance må oppnås innen 2 uker etter randomisering og beregnet kreatininclearance (CrCl) må være >= 45 ml/min ved bruk av standard Cockcroft og Gault-formelen, eller den målte glomerulære filtrasjonshastigheten (GFR) ved bruk av passende radiomerket metode ([ 51]krommerket etylendiamintetraeddiksyre [51-CrEDTA] eller technetium 99m dietylentriamin-pentaeddiksyre [Tc99m-DTPA]) må brukes for å beregne CrCl

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Primært formål: Behandling
Tildeling: Randomisert
Intervensjonsmodell: Parallell tildeling
Masking: Ingen (Open Label)

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm	Intervensjon / Behandling
Aktiv komparator: Arm I (kjemoterapi) Pasienter får en av følgende. For alle gjentas behandlingen hver 21. dag i opptil 4 kurer i fravær av sykdomsprogresjon eller uakseptabel toksisitet. REGIMEN 1: Vinorelbinditartrat 30 mg/m2 IV på dag 1 og 8, cisplatin 75 mg/m2 IV over 60 minutter på dag 1 REGIMEN 2: Docetaxel 75 mg/m2 IV og cisplastin 75 mg/m2 IV på dag 1 REGIMEN 3: Gemcitabinhydroklorid 1200 mg/m2 IV på dag 1 og 8, cisplatin 75 mg/m2 IV på dag 1 REGIMEN 4 (kun ikke-plateepitelhistologi): Pemetrexed dinatrium 500mg/m2 IV og cisplatin 75 mg/m2 IV på dag 1	Annen: Laboratoriebiomarkøranalyse Korrelative studier Annen: Spørreskjemaadministrasjon Hjelpestudier Legemiddel: Cisplatin Gitt IV Andre navn: CDDP Cis-diammindikloridplatina Cismaplat Cisplatinum Neoplatin Platinol Abiplatin Blastolem Briplatin Cis-diammin-diklorplatina Cis-diamindiklor platina (II) Cis-diamindiklorplatina Cis-dikloramin platina (II) Cis-platinøs diamin diklorid Cis-platina Cis-platina II Cis-platina II diamin diklorid Cisplatina Cisplatyl Citoplatino Citosin Cysplatyna DDP Lederplatin Metaplatin Peyrones klorid Peyrones salt Placis Plastistil Platamin Platiblastin Platiblastin-S Platinex Platinol-AQ Platinol-AQ VHA Plus Platinoxan Platina Platina diaminodiklorid Platiran Platistin Platosin Legemiddel: Docetaxel Gitt IV Andre navn: Taxotere Docecad RP56976 Taxotere injeksjonskonsentrat RP 56976 Legemiddel: Pemetrexed dinatrium Gitt IV Andre navn: Alimta LY231514 N-[4-[2-(2-amino-4,7-dihydro-4-okso-1H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre dinatriumsalt Almita Legemiddel: Gemcitabinhydroklorid Gitt IV Andre navn: Gemzar dFdCyd Difluordeoksycytidinhydroklorid Gemcitabin HCI LY-188011 LY188011 Legemiddel: Vinorelbin tartrat Gitt IV Andre navn: Navelbine Eunades NVB Biovelbin KW-2307 Navelbine Ditartrate Vinorelbin-ditartrat
Eksperimentell: Arm II (kjemoterapi, bevacizumab) Pasienter får kjemoterapi som i arm I. Pasienter får også bevacizumab IV over 30-90 minutter på dag 1. Behandling med bevacizumab gjentas hver 21. dag i opptil 1 år.	Annen: Laboratoriebiomarkøranalyse Korrelative studier Annen: Spørreskjemaadministrasjon Hjelpestudier Legemiddel: Cisplatin Gitt IV Andre navn: CDDP Cis-diammindikloridplatina Cismaplat Cisplatinum Neoplatin Platinol Abiplatin Blastolem Briplatin Cis-diammin-diklorplatina Cis-diamindiklor platina (II) Cis-diamindiklorplatina Cis-dikloramin platina (II) Cis-platinøs diamin diklorid Cis-platina Cis-platina II Cis-platina II diamin diklorid Cisplatina Cisplatyl Citoplatino Citosin Cysplatyna DDP Lederplatin Metaplatin Peyrones klorid Peyrones salt Placis Plastistil Platamin Platiblastin Platiblastin-S Platinex Platinol-AQ Platinol-AQ VHA Plus Platinoxan Platina Platina diaminodiklorid Platiran Platistin Platosin Legemiddel: Docetaxel Gitt IV Andre navn: Taxotere Docecad RP56976 Taxotere injeksjonskonsentrat RP 56976 Legemiddel: Pemetrexed dinatrium Gitt IV Andre navn: Alimta LY231514 N-[4-[2-(2-amino-4,7-dihydro-4-okso-1H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre dinatriumsalt Almita Legemiddel: Gemcitabinhydroklorid Gitt IV Andre navn: Gemzar dFdCyd Difluordeoksycytidinhydroklorid Gemcitabin HCI LY-188011 LY188011 Biologisk: Bevacizumab Gitt IV Andre navn: Avastin ABP 215 Anti-VEGF Anti-VEGF humanisert monoklonalt antistoff Anti-VEGF monoklonalt antistoff SIBP04 Anti-VEGF rhuMAb Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Immunoglobulin G1 (Human-mus monoklonal rhuMab-VEGF Gamma-kjede anti-human vaskulær endotelial vekstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF lett kjede, dimer Mvasi MYL-1402O Rekombinant humanisert anti-VEGF monoklonalt antistoff rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev QL1101 Bevacizumab Biosimilar QL1101 BAT1706 BAT 1706 BAT-1706 BAT1706 Biosimilar Bevacizumab Biosimilar BAT1706 Bevacizumab-adcd CT-P16 Vegzelma Legemiddel: Vinorelbin tartrat Gitt IV Andre navn: Navelbine Eunades NVB Biovelbin KW-2307 Navelbine Ditartrate Vinorelbin-ditartrat

Deltakergruppe / Arm

Intervensjon / Behandling

Aktiv komparator: Arm I (kjemoterapi)

Pasienter får en av følgende. For alle gjentas behandlingen hver 21. dag i opptil 4 kurer i fravær av sykdomsprogresjon eller uakseptabel toksisitet.

REGIMEN 1: Vinorelbinditartrat 30 mg/m2 IV på dag 1 og 8, cisplatin 75 mg/m2 IV over 60 minutter på dag 1 REGIMEN 2: Docetaxel 75 mg/m2 IV og cisplastin 75 mg/m2 IV på dag 1 REGIMEN 3: Gemcitabinhydroklorid 1200 mg/m2 IV på dag 1 og 8, cisplatin 75 mg/m2 IV på dag 1 REGIMEN 4 (kun ikke-plateepitelhistologi): Pemetrexed dinatrium 500mg/m2 IV og cisplatin 75 mg/m2 IV på dag 1

Annen: Laboratoriebiomarkøranalyse

Korrelative studier

Annen: Spørreskjemaadministrasjon

Hjelpestudier

Legemiddel: Cisplatin

Gitt IV

Andre navn:

CDDP
Cis-diammindikloridplatina
Cismaplat
Cisplatinum
Neoplatin
Platinol
Abiplatin
Blastolem
Briplatin
Cis-diammin-diklorplatina
Cis-diamindiklor platina (II)
Cis-diamindiklorplatina
Cis-dikloramin platina (II)
Cis-platinøs diamin diklorid
Cis-platina
Cis-platina II
Cis-platina II diamin diklorid
Cisplatina
Cisplatyl
Citoplatino
Citosin
Cysplatyna
DDP
Lederplatin
Metaplatin
Peyrones klorid
Peyrones salt
Placis
Plastistil
Platamin
Platiblastin
Platiblastin-S
Platinex
Platinol-AQ
Platinol-AQ VHA Plus
Platinoxan
Platina
Platina diaminodiklorid
Platiran
Platistin
Platosin

Legemiddel: Docetaxel

Gitt IV

Andre navn:

Taxotere
Docecad
RP56976
Taxotere injeksjonskonsentrat
RP 56976

Legemiddel: Pemetrexed dinatrium

Gitt IV

Andre navn:

Alimta
LY231514
N-[4-[2-(2-amino-4,7-dihydro-4-okso-1H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre dinatriumsalt
Almita

Legemiddel: Gemcitabinhydroklorid

Gitt IV

Andre navn:

Gemzar
dFdCyd
Difluordeoksycytidinhydroklorid
Gemcitabin HCI
LY-188011
LY188011

Legemiddel: Vinorelbin tartrat

Gitt IV

Andre navn:

Navelbine
Eunades
NVB
Biovelbin
KW-2307
Navelbine Ditartrate
Vinorelbin-ditartrat

Eksperimentell: Arm II (kjemoterapi, bevacizumab)

Pasienter får kjemoterapi som i arm I. Pasienter får også bevacizumab IV over 30-90 minutter på dag 1. Behandling med bevacizumab gjentas hver 21. dag i opptil 1 år.

Annen: Laboratoriebiomarkøranalyse

Korrelative studier

Annen: Spørreskjemaadministrasjon

Hjelpestudier

Legemiddel: Cisplatin

Gitt IV

Andre navn:

CDDP
Cis-diammindikloridplatina
Cismaplat
Cisplatinum
Neoplatin
Platinol
Abiplatin
Blastolem
Briplatin
Cis-diammin-diklorplatina
Cis-diamindiklor platina (II)
Cis-diamindiklorplatina
Cis-dikloramin platina (II)
Cis-platinøs diamin diklorid
Cis-platina
Cis-platina II
Cis-platina II diamin diklorid
Cisplatina
Cisplatyl
Citoplatino
Citosin
Cysplatyna
DDP
Lederplatin
Metaplatin
Peyrones klorid
Peyrones salt
Placis
Plastistil
Platamin
Platiblastin
Platiblastin-S
Platinex
Platinol-AQ
Platinol-AQ VHA Plus
Platinoxan
Platina
Platina diaminodiklorid
Platiran
Platistin
Platosin

Legemiddel: Docetaxel

Gitt IV

Andre navn:

Taxotere
Docecad
RP56976
Taxotere injeksjonskonsentrat
RP 56976

Legemiddel: Pemetrexed dinatrium

Gitt IV

Andre navn:

Alimta
LY231514
N-[4-[2-(2-amino-4,7-dihydro-4-okso-1H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre dinatriumsalt
Almita

Legemiddel: Gemcitabinhydroklorid

Gitt IV

Andre navn:

Gemzar
dFdCyd
Difluordeoksycytidinhydroklorid
Gemcitabin HCI
LY-188011
LY188011

Biologisk: Bevacizumab

Gitt IV

Andre navn:

Avastin
ABP 215
Anti-VEGF
Anti-VEGF humanisert monoklonalt antistoff
Anti-VEGF monoklonalt antistoff SIBP04
Anti-VEGF rhuMAb
Bevacizumab awwb
Bevacizumab Biosimilar ABP 215
Bevacizumab Biosimilar BEVZ92
Bevacizumab Biosimilar BI 695502
Bevacizumab Biosimilar CBT 124
Bevacizumab Biosimilar CT-P16
Bevacizumab Biosimilar FKB238
Bevacizumab Biosimilar GB-222
Bevacizumab Biosimilar HD204
Bevacizumab Biosimilar HLX04
Bevacizumab Biosimilar IBI305
Bevacizumab Biosimilar LY01008
Bevacizumab Biosimilar MIL60
Bevacizumab Biosimilar Mvasi
Bevacizumab Biosimilar MYL-1402O
Bevacizumab Biosimilar QL 1101
Bevacizumab Biosimilar RPH-001
Bevacizumab Biosimilar SCT501
Bevacizumab Biosimilar Zirabev
Bevacizumab-awwb
Bevacizumab-bvzr
BP102
BP102 Biosimilar
HD204
Immunoglobulin G1 (Human-mus monoklonal rhuMab-VEGF Gamma-kjede anti-human vaskulær endotelial vekstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF lett kjede, dimer
Mvasi
MYL-1402O
Rekombinant humanisert anti-VEGF monoklonalt antistoff
rhuMab-VEGF
SCT501
SIBP 04
SIBP-04
SIBP04
Zirabev
QL1101
Bevacizumab Biosimilar QL1101
BAT1706
BAT 1706
BAT-1706
BAT1706 Biosimilar
Bevacizumab Biosimilar BAT1706
Bevacizumab-adcd
CT-P16
Vegzelma

Legemiddel: Vinorelbin tartrat

Gitt IV

Andre navn:

Navelbine
Eunades
NVB
Biovelbin
KW-2307
Navelbine Ditartrate
Vinorelbin-ditartrat

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Samlet overlevelse Tidsramme: Fra registrering til død, inntil 10 år	Total overlevelse (OS) ble definert som tiden fra randomisering til død uansett årsak, og pasienter som ble antatt å være i live på tidspunktet for endelig analyse ble sensurert på siste kontaktdato. Studien klarte ikke å møte sitt primære endepunkt.	Fra registrering til død, inntil 10 år

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Sykdomsfri overlevelse Tidsramme: Fra registrering til død, inntil 10 år	Sykdomsfri overlevelse (DFS) ble definert som tiden fra randomisering til en hendelse. Hendelser inkluderer tilbakefall av sykdom, ny primær av lungekreft, andre primære eller død, avhengig av hva som skjedde først; Det bør imidlertid bemerkes at pasienter med nye primære krefter på andre steder som ikke er lunge, bør ha fortsatt oppfølging for tilbakefall av den opprinnelige kreftsykdommen. Pasienter som ikke har hatt en hendelse rapportert ved analyse, ble sensurert på siste dato for sykdomsvurdering.	Fra registrering til død, inntil 10 år

Andre resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Toksisitetsrater vurdert av National Cancer Institute Common Terminology Criteria for Adverse Events Versjon 4.0 Tidsramme: Inntil 1 år etter behandling	Hvis forskjellen i frekvensen av en bestemt kategori av toksisitet mellom de 2 armene (N=750 per arm) er minst 5 % (4 % vs. 9 %), kan 96 % effekt oppnås ved å anta et signifikansnivå på 5 % (tosidig Chi Square-test) og at den lavere toksisitetsraten for en arm er 4 %. En forskjell i frekvensen av grad 3-5 arterielle tromboemboliske hendelser og blødningshendelser vil bli overvåket og vurdert mellom behandlingsarmene.	Inntil 1 år etter behandling
Utfør analyser av vev og blod for å etablere faktorer som forutsier klinisk utfall hos pasienter som får kjemoterapi, med eller uten bevacizumab, for reseksjonert tidlig stadium av NSCLC. Tidsramme: Fra registrering til død, inntil 10 år		Fra registrering til død, inntil 10 år
For å avgjøre om røykestatus er knyttet til utfallet for pasienter med reseksjonert stadium IB - IIIA NSCLC behandlet med kjemoterapi med eller uten bevacizumab i adjuvant setting. Tidsramme: Fra registrering til død, inntil 10 år		Fra registrering til død, inntil 10 år

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

National Cancer Institute (NCI)

Samarbeidspartnere

NCIC Clinical Trials Group

Cancer and Leukemia Group B

North Central Cancer Treatment Group

SWOG Cancer Research Network

Etterforskere

Hovedetterforsker: Heather A Wakelee, ECOG-ACRIN Cancer Research Group

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Wakelee HA, Dahlberg SE, Keller SM, Tester WJ, Gandara DR, Graziano SL, Adjei AA, Leighl NB, Aisner SC, Rothman JM, Patel JD, Sborov MD, McDermott SR, Perez-Soler R, Traynor AM, Butts C, Evans T, Shafqat A, Chapman AE, Kasbari SS, Horn L, Ramalingam SS, Schiller JH; ECOG-ACRIN. Adjuvant chemotherapy with or without bevacizumab in patients with resected non-small-cell lung cancer (E1505): an open-label, multicentre, randomised, phase 3 trial. Lancet Oncol. 2017 Dec;18(12):1610-1623. doi: 10.1016/S1470-2045(17)30691-5. Epub 2017 Nov 9.

Hjelpsomme linker

Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive.

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

1. juni 2007

Primær fullføring (Faktiske)

20. oktober 2015

Studiet fullført (Antatt)

16. oktober 2024

Datoer for studieregistrering

Først innsendt

10. mai 2006

Først innsendt som oppfylte QC-kriteriene

10. mai 2006

Først lagt ut (Antatt)

11. mai 2006

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

17. april 2024

Siste oppdatering sendt inn som oppfylte QC-kriteriene

16. april 2024

Sist bekreftet

1. april 2024

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

NCI-2009-00509 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
U10CA180820 (U.S. NIH-stipend/kontrakt)
U10CA021115 (U.S. NIH-stipend/kontrakt)
09-0404
E1505 (Annen identifikator: CTEP)
CDR0000475774
ECOG-E1505

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Kliniske studier på Stage IB lunge ikke-småcellet karsinom AJCC v7

National Cancer Institute (NCI)

Fullført

Pembrolizumab i behandling av pasienter med tilbakefall eller refraktært stadium IB-IVB Mycosis Fungoides eller Sezary Syndrome

Tilbakevendende Mycosis Fungoides og Sezary Syndrome | Refractory Mycosis Fungoides og Sezary Syndrome | Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v7 | Stage IIA Mycosis Fungoides og Sezary Syndrome AJCC v7 | Stage IIB Mycosis Fungoides og Sezary Syndrome AJCC v7 | Stage IIIA Mycosis... og andre forhold

Forente stater
National Cancer Institute (NCI)

Fullført

Tester kombinasjonen av to eksperimentelle legemidler MK-3475 (Pembrolizumab) og interferon-gamma for behandling av Mycosis Fungoides og Sézary syndrom og avansert synovialt sarkom

Tilbakevendende Mycosis Fungoides og Sezary Syndrome | Refractory Mycosis Fungoides og Sezary Syndrome | Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v7 | Stage IIA Mycosis Fungoides og Sezary Syndrome AJCC v7 | Stage IIB Mycosis Fungoides og Sezary Syndrome AJCC v7 | Stage IIIA Mycosis... og andre forhold

Forente stater
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Anti-ICOS monoklonalt antistoff MEDI-570 i behandling av pasienter med residiverende eller refraktær perifert T-celle lymfom follikulær variant eller angioimmunoblastisk T-celle lymfom

Tilbakevendende grad 1 follikulært lymfom | Tilbakevendende grad 2 follikulært lymfom | Avansert primær kutan T-celle non-Hodgkin lymfom | Tilbakevendende grad 3a follikulært lymfom | Tilbakevendende moden T-celle og NK-celle non-Hodgkin lymfom | Tilbakevendende Mycosis Fungoides | Tilbakevendende... og andre forhold

Forente stater, Canada
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Samotolisib i behandling av pasienter med residiverende eller refraktære avanserte solide svulster, non-Hodgkin-lymfom eller histiocytiske lidelser med TSC- eller PI3K/MTOR-mutasjoner (A Pediatric MATCH Treatment Trial)

Ondartet gliom | Rabdoide svulst | Avansert malignt solid neoplasma | Ildfast malignt fast neoplasma | Tilbakevendende ependymom | Tilbakevendende Ewing-sarkom | Tilbakevendende hepatoblastom | Tilbakevendende Langerhans Cell Histiocytose | Tilbakevendende ondartet kimcelletumor | Tilbakevendende ondartet... og andre forhold

Forente stater, Puerto Rico
National Cancer Institute (NCI)

Rekruttering

Målrettet terapi rettet av genetisk testing ved behandling av pediatriske pasienter med residiverende eller refraktære avanserte solide svulster, non-Hodgkin lymfomer eller histiocytiske lidelser (The Pediatric MATCH Screening Trial)

Ondartet gliom | Rabdoide svulst | Avansert malignt solid neoplasma | Ildfast malignt fast neoplasma | Tilbakevendende ependymom | Tilbakevendende Ewing-sarkom | Tilbakevendende hepatoblastom | Tilbakevendende Langerhans Cell Histiocytose | Tilbakevendende ondartet kimcelletumor | Tilbakevendende ondartet... og andre forhold

Forente stater, Puerto Rico, Australia, Canada
National Cancer Institute (NCI)
Children's Oncology Group

Aktiv, ikke rekrutterende

Tazemetostat ved behandling av pasienter med residiverende eller refraktære avanserte solide svulster, non-Hodgkin-lymfom eller histiocytiske lidelser med EZH2-, SMARCB1- eller SMARCA4-genmutasjoner (A Pediatric MATCH Treatment Trial)

Tilbakevendende Hodgkin-lymfom | Refraktært Hodgkin-lymfom | Rabdoide svulst | Avansert malignt solid neoplasma | Ildfast malignt fast neoplasma | Ann Arbor stadium III Hodgkin lymfom | Ann Arbor stadium IV Hodgkin lymfom | Tilbakevendende ependymom | Tilbakevendende Ewing-sarkom | Tilbakevendende hepatoblastom og andre forhold

Forente stater, Puerto Rico
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Fullført

Doseovervåking av Busulfan og kombinasjonskjemoterapi ved Hodgkin- eller Non-Hodgkin-lymfom som gjennomgår stamcelletransplantasjon

Ekstranodal marginalsone B-celle lymfom av slimhinne-assosiert lymfoid vev | Nodal Marginal Zone B-celle lymfom | Tilbakevendende voksen Burkitt lymfom | Tilbakevendende voksent diffust storcellet lymfom | Tilbakevendende voksent diffust blandet celle lymfom | Tilbakevendende voksent diffust småcellet... og andre forhold

Forente stater
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Fullført

Takrolimus og mykofenolatmofetil i forebygging av graft-versus-vert-sykdom hos pasienter som har gjennomgått bestråling av hele kroppen med eller uten fludarabinfosfat etterfulgt av donor perifer blodstamcelletransplantasjon for hematologisk kreft

Primær myelofibrose | Polycytemi Vera | Essensiell trombocytemi | Stage I Myelom | Stadium II multippelt myelom | Stadium III multippelt myelom | Tilbakevendende akutt myeloid leukemi hos voksne | Ekstranodal marginalsone B-celle lymfom av slimhinne-assosiert lymfoid vev | Nodal Marginal Zone B-celle lymfom og andre forhold

Forente stater, Italia
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Fullført

Fludarabin og totalkroppsbestråling etterfulgt av donorstamcelletransplantasjon og cyklosporin og mykofenolatmofetil ved behandling av HIV-positive pasienter med eller uten kreft

HIV-infeksjon | Uspesifisert solid barndomssvulst, protokollspesifikk | Primær myelofibrose | Polycytemi Vera | Essensiell trombocytemi | Stage I Myelom | Stadium II multippelt myelom | Stadium III multippelt myelom | Kronisk myelomonocytisk leukemi | Juvenil myelomonocytisk leukemi | Ekstranodal marginalsone... og andre forhold

Forente stater

Kliniske studier på Laboratoriebiomarkøranalyse

Fondation Lenval

Tilbaketrukket

Påvirkning av utmattelse på gangmønsteret hos pasienter med cerebral parese.

Cerebral parese

Frankrike
Liao Jian An

Rekruttering

Meridianenergiendringer hos pasienter med hode- og nakkekreft etter kjemoterapi eller strålebehandling

Hode- og nakkekreft

Taiwan
Progenity, Inc.

Fullført

Utvidet ikke-invasiv genomisk medisinsk vurdering: Enigma-studien

Downs syndrom | Aneuploidi | DiGeorge syndrom | Turners syndrom | Klinefelters syndrom | Kromosomsletting | Edwards syndrom | Patau syndrom

Forente stater
Tel-Aviv Sourasky Medical Center

Ukjent

Evaluering av evnen til CT-basert endelig elementanalyse (CTFEA) til å forutsi frakturer hos pasienter med metastaser: en randomisert kontrollert studie. (ZYCTFEA)

Benmetastaser | Ortopedisk lidelse | Benneoplasma i hoften (diagnose) | Proksimal femoral metafyseal abnormitet
IRCCS Eugenio Medea

Rekruttering

Biomarkørers baner for tidlig intervensjon hos søsken til barn med autismespekterforstyrrelse

Autismespektrumforstyrrelse | Tidlig intervensjon

Italia
Oregon Health and Science University
4DMedical

Påmelding etter invitasjon

Ventilasjonsubalanser ved mild til moderat kronisk obstruktiv lungesykdom (VAPOR)

Lungesykdommer | KOLS | Luftveissykdom | Dyspné

Forente stater
IRCCS Eugenio Medea

Rekruttering

Bekreft ytelsen i klinisk praksis til den oppslukende virtuelle virkelighetsplattformen GRAIL (Gait Real-time Analysis Interactive Lab)

Cerebral parese | Ervervet hjerneskade

Italia
Duke University

Tilbaketrukket

Point of Care-testing for å forbedre overvåking av LVAD-pasienter

Antikoagulasjons- og trombosepunkttest (AT-POCT)

Forente stater
Modarres Hospital

Fullført

Renal parenkymal kjernenålbiopsi

Komplikasjoner | Bildeveiledet biopsi | Nyre Glomerulus

Iran, den islamske republikken
University of California, Los Angeles

Fullført

Sikkerhet ved kroppssammensetningsanalyse hos hjertesviktpasienter med implanterbare cardioverter-defibrillatorer (ICD)

Hjertefeil | Overvekt

Forente stater

Kjemoterapi med eller uten bevacizumab ved behandling av pasienter med stadium IB, stadium II eller stadium IIIA ikke-småcellet lungekreft som ble fjernet ved kirurgi

En randomisert fase III-studie av adjuvant kjemoterapi med eller uten Bevacizumab for pasienter med fullstendig reseksjonert stadium IB (≥ 4 cm) - IIIA ikke-småcellet lungekreft (NSCLC)

Studieoversikt

Status

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Studietype

Registrering (Faktiske)

Fase

Kontakter og plasseringer

Studiesteder

Deltakelseskriterier

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Tar imot friske frivillige

Beskrivelse

Studieplan

Hvordan er studiet utformet?

Designdetaljer

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm

Intervensjon / Behandling

Hva måler studien?

Primære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Andre resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Samarbeidspartnere og etterforskere

Sponsor

Samarbeidspartnere

Etterforskere

Publikasjoner og nyttige lenker

Generelle publikasjoner

Hjelpsomme linker

Studierekorddatoer

Studer hoveddatoer

Studiestart (Faktiske)

Primær fullføring (Faktiske)

Studiet fullført (Antatt)

Datoer for studieregistrering

Først innsendt

Først innsendt som oppfylte QC-kriteriene

Først lagt ut (Antatt)

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

Siste oppdatering sendt inn som oppfylte QC-kriteriene

Sist bekreftet

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

Kliniske studier på Stage IB lunge ikke-småcellet karsinom AJCC v7

Kliniske studier på Laboratoriebiomarkøranalyse

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Sponsorer og samarbeidspartnere

Medisinsk tilstand

Legemiddelintervensjoner

CROs by country

CROs in Morocco

Forhold

Sjeldne sykdommer

Legemiddelintervensjoner

Kosttilskudd

Sponsor / samarbeidspartnere

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