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Oksaliplatin, Leucovorin Kalsium og Fluorouracil med eller uten Celecoxib ved behandling av pasienter med stadium III tykktarmskreft tidligere behandlet med kirurgi

28. april 2026 oppdatert av: Alliance for Clinical Trials in Oncology

En fase III-studie med 6 versus 12 behandlinger av adjuvant FOLFOX Plus Celecoxib eller placebo for pasienter med reseksjonert stadium III tykktarmskreft

FORMÅL: Denne randomiserte fase III studien studerer å gi oksaliplatin, leucovorin kalsium og fluorouracil sammen for å sammenligne hvor godt de virker når de gis sammen med eller uten celecoxib i behandling av pasienter med stadium III tykktarmskreft tidligere behandlet med kirurgi.

BAKGRUNN: Legemidler som brukes i kjemoterapi, som oksaliplatin, leukovorin kalsium og fluorouracil, virker på forskjellige måter for å stoppe veksten av tumorceller, enten ved å drepe cellene eller ved å hindre dem i å dele seg. Celecoxib kan stoppe veksten av tumorceller ved å blokkere noen av enzymene som trengs for cellevekst. Det er foreløpig ikke kjent om det å gi oksaliplatin, leucovorin kalsium og fluorouracil er mer effektivt med eller uten celecoxib ved behandling av tykktarmskreft.

Studieoversikt

Status

Fullført

Forhold

Tykktarmskreft

Intervensjon / Behandling

Detaljert beskrivelse

OVERSIKT: Dette er en multisenterstudie. Pasientene er stratifisert etter antall positive lymfeknuter* (1-3 vs 4 eller mer) og samtidige vanlige lavdoser av aspirin (ja vs nei). Pasientene er randomisert til 1 av 4 behandlingsarmer. Se delen "Arms" for mer informasjon. I alle armer fortsetter behandlingen med celecoxib eller placebo i 3 år i fravær av sykdomsprogresjon eller uakseptabel toksisitet. Blod- og vevsprøver kan samles inn for biomarkøranalyse og farmakogenomiske studier. De primære og sekundære målene for forskningsstudien er beskrevet nedenfor.

Hovedmål:

1. For å sammenligne sykdomsfri overlevelse av pasienter med stadium III tykktarmskreft randomisert til standard kjemoterapi kun FOLFOX eller standard kjemoterapi FOLFOX med 3 år med celecoxib 400 mg daglig.

Sekundære mål:

Å bidra til en internasjonal prospektiv samlet analyse som vil sammenligne sykdomsfri overlevelse av pasienter med stadium III tykktarmskreft randomisert til 6 behandlinger med adjuvant FOLFOX kjemoterapi eller 12 behandlinger med adjuvant FOLFOX kjemoterapi.
For å sammenligne total overlevelse av pasienter med stadium III tykktarmskreft randomisert til kun standard kjemoterapi (FOLFOX) eller standard kjemoterapi (FOLFOX) med 3 år med celecoxib 400 mg daglig.
Å bidra til en internasjonal prospektiv samlet analyse som vil sammenligne total overlevelse av pasienter med stadium III tykktarmskreft randomisert til 6 behandlinger med adjuvant FOLFOX kjemoterapi eller 12 behandlinger med adjuvant FOLFOX kjemoterapi eller 12 behandlinger med adjuvant FOLFOX kjemoterapi.
For å vurdere toksisitet av celecoxib som vedlikeholdsadjuvant terapi hos pasienter med stadium III tykktarmskreft.
For å vurdere forskjeller i kardiovaskulære spesifikke hendelser med celecoxib versus placebo i en populasjon av overlevende av stadium III tykktarmskreft.
For å evaluere forskjeller i toksisitet, spesielt kumulativ perifer nevropati, for pasienter behandlet med 6 behandlinger med FOLFOX sammenlignet med de som ble behandlet med 12 behandlinger med FOLFOX.

Etter avsluttet studieterapi følges pasientene opp hver 6. måned i opptil 6 år.

Studietype

Intervensjonell

Registrering (Faktiske)

2527

Fase

Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

Canada
- Alberta
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 5L3
    - BCCA-Cancer Centre for the Southern Interior
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - BCCA-Vancouver Cancer Centre
- New Brunswick
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Horizon Health Network-Saint John Regional Hospital
- Ontario
  - Cambridge, Ontario, Canada, N1R 3G2
    - Cambridge Memorial Hospital
  - Greater Sudbury, Ontario, Canada, P3E 5J1
    - Health Sciences North
  - London, Ontario, Canada, N6A 4L6
    - London Regional Cancer Program
  - Saint Catharines, Ontario, Canada, ON L2S 0A9
    - Niagara Health System-Saint Catharines General
  - Toronto, Ontario, Canada, M4C 3E7
    - Toronto East General Hospital
  - Toronto, Ontario, Canada, M5G 1X5
    - Mount Sinai Hospital - Toronto
- Prince Edward Island
  - Charlottetown, Prince Edward Island, Canada, C1A 8T5
    - PEI Cancer Treatment Centre-Queen Elizabeth Hospital
- Quebec
  - Montreal, Quebec, Canada, H2W 1S6
    - McGill University Department of Oncology
  - Sherbrooke, Quebec, Canada, J1H 5N4
    - Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre
Forente stater
- Alabama
  - Mobile, Alabama, Forente stater, 36604
    - University of South Alabama Mitchell Cancer Institute
- Alaska
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forente stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forente stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forente stater, 99508
    - Providence Alaska Medical Center
  - Fairbanks, Alaska, Forente stater, 99701
    - Fairbanks Memorial Hospital
- Arkansas
  - Jonesboro, Arkansas, Forente stater, 72401
    - Fowler Family Center for Cancer Care
- California
  - Auburn, California, Forente stater, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Berkeley, California, Forente stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forente stater, 91505
    - Providence Saint Joseph Medical Center-Disney Family Cancer Center
  - Burlingame, California, Forente stater, 94010
    - Mills-Peninsula Hospitals
  - Cameron Park, California, Forente stater, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Concord, California, Forente stater, 95420
    - John Muir Medical Center-Concord
  - Davis, California, Forente stater, 95616
    - Sutter Davis Hospital
  - Duarte, California, Forente stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Dublin, California, Forente stater, 94568
    - Epic Care-Dublin
  - Emeryville, California, Forente stater, 94608
    - Bay Area Breast Surgeons Inc
  - Emeryville, California, Forente stater, 94608
    - Epic Care Partners in Cancer Care
  - Englewood, California, Forente stater, 80113
    - Comprehensive Cancer Care and Research Institute of Colorado LLC
  - Fresno, California, Forente stater, 93701
    - University Oncology Associates
  - Fresno, California, Forente stater, 93720
    - California Cancer Center - North Fresno
  - Greenbrae, California, Forente stater, 94904
    - Marin Cancer Care Inc
  - Greenbrae, California, Forente stater, 94904
    - Marin General Hospital
  - Los Angeles, California, Forente stater, 90033
    - Los Angeles County-USC Medical Center
  - Los Angeles, California, Forente stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forente stater, 90033-0804
    - USC/Norris Comprehensive Cancer Center
  - Martinez, California, Forente stater, 94553
    - Contra Costa Regional Medical Center
  - Modesto, California, Forente stater, 95355
    - Memorial Medical Center
  - Mountain View, California, Forente stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forente stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Novato, California, Forente stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forente stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forente stater, 94609
    - Hematology and Oncology Associates-Oakland
  - Oakland, California, Forente stater, 94609
    - Bay Area Tumor Institute
  - Orange, California, Forente stater, 92868
    - Saint Joseph Hospital - Orange
  - Orange, California, Forente stater, 92868
    - UC Irvine Health-Chao Family Comprehensive Cancer Center
  - Palm Springs, California, Forente stater, 92262
    - Desert Regional Medical Center
  - Palo Alto, California, Forente stater, 94304
    - Stanford Cancer Institute
  - Pismo Beach, California, Forente stater, 93449
    - Palchak David MD
  - Pleasanton, California, Forente stater, 94588
    - Valley Medical Oncology Consultants
  - Redwood City, California, Forente stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forente stater, 94801
    - Kaiser Permanente-Richmond
  - Riverside, California, Forente stater, 92505
    - Kaiser Permanente-Riverside
  - Roseville, California, Forente stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forente stater, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Forente stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forente stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forente stater, 95816
    - Sutter General Hospital
  - Salinas, California, Forente stater, 93901
    - Salinas Valley Memorial
  - Salinas, California, Forente stater, 93901
    - Salinas Valley Memorial Hospital
  - San Diego, California, Forente stater, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Forente stater, 92134
    - Naval Medical Center-San Diego
  - San Francisco, California, Forente stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forente stater, 94158
    - UCSF Medical Center-Mission Bay
  - San Francisco, California, Forente stater, 94115
    - UCSF Medical Center-Mount Zion
  - San Francisco, California, Forente stater, 94118
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, Forente stater, 94121
    - Veterans Affairs Medical Center-San Francisco
  - San Jose, California, Forente stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Jose, California, Forente stater, 95128
    - Santa Clara Valley Medical Center
  - San Leandro, California, Forente stater, 94577
    - Kaiser Permanente San Leandro
  - San Rafael, California, Forente stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forente stater, 95051
    - Kaiser Permanente Medical Center-Santa Clara
  - Santa Cruz, California, Forente stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Rosa, California, Forente stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forente stater, 95403
    - Sutter Pacific Medical Foundation
  - South San Francisco, California, Forente stater, 94080
    - Kaiser Permanente-South San Francisco
  - St. Helena, California, Forente stater, 95474
    - Saint Helena Hospital
  - Stockton, California, Forente stater, 95210
    - Kaiser Permanente-Stockton
  - Sunnyvale, California, Forente stater, 94806
    - Palo Alto Medical Foundation-Sunnyvale
  - Vacaville, California, Forente stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vacaville, California, Forente stater, 95687
    - Sutter Cancer Centers Radiation Oncology Services-Vacaville
  - Vallejo, California, Forente stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forente stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forente stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Walnut Creek, California, Forente stater, 94598
    - John Muir Medical Center-Walnut Creek
- Colorado
  - Aurora, Colorado, Forente stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forente stater, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, Forente stater, 80045
    - University of Colorado Cancer Center-Anschutz Cancer Pavilion
  - Boulder, Colorado, Forente stater, 80301
    - Boulder Community Hospital
  - Boulder, Colorado, Forente stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Forente stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forente stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, Forente stater, 80909
    - Memorial Hospital Colorado Springs
  - Denver, Colorado, Forente stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forente stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forente stater, 80218
    - Exempla Saint Joseph Hospital
  - Denver, Colorado, Forente stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forente stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forente stater, 80907
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forente stater, 80222
    - Colorado Cancer Research Program NCORP
  - Denver, Colorado, Forente stater, 80218
    - Presbyterian-Saint Lukes Medical Center-Health One
  - Durango, Colorado, Forente stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forente stater, 81301
    - Southwest Oncology PC
  - Englewood, Colorado, Forente stater, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Forente stater, 80524
    - Poudre Valley Hospital
  - Golden, Colorado, Forente stater, 80401
    - Mountain Blue Cancer Care Center
  - Greeley, Colorado, Forente stater, 80631
    - North Colorado Medical Center
  - Greenwood Village, Colorado, Forente stater, 80111
    - Rocky Mountain Cancer Centers-Greenwood Village
  - Lakewood, Colorado, Forente stater, 80228
    - Saint Anthony Hospital
  - Lakewood, Colorado, Forente stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forente stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forente stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forente stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forente stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forente stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forente stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forente stater, 80539
    - McKee Medical Center
  - Parker, Colorado, Forente stater, 80138
    - Parker Adventist Hospital
  - Parker, Colorado, Forente stater, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Pueblo, Colorado, Forente stater, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Forente stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Wheat Ridge, Colorado, Forente stater, 80033
    - Exempla Lutheran Medical Center
- Connecticut
  - Hartford, Connecticut, Forente stater, 06102
    - Hartford Hospital
  - Hartford, Connecticut, Forente stater, 06105
    - Saint Francis Hospital and Medical Center
  - Meriden, Connecticut, Forente stater, 06451
    - Midstate Medical Center
  - New Britain, Connecticut, Forente stater, 06050
    - The Hospital of Central Connecticut
  - Norwalk, Connecticut, Forente stater, 06856
    - Norwalk Hospital
- Delaware
  - Lewes, Delaware, Forente stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forente stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forente stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forente stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forente stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Newark, Delaware, Forente stater, 19713
    - Christiana Gynecologic Oncology LLC
  - Newark, Delaware, Forente stater, 19713
    - Regional Hematology and Oncology PA
  - Rehoboth Beach, Delaware, Forente stater, 19971
    - Beebe Health Campus
  - Sanford, Delaware, Forente stater, 19973
    - Nanticoke Memorial Hospital
  - Wilmington, Delaware, Forente stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Forente stater, 20010
    - MedStar Washington Hospital Center
  - Washington D.C., District of Columbia, Forente stater, 20007
    - MedStar Georgetown University Hospital
  - Washington D.C., District of Columbia, Forente stater, 20016
    - Sibley Memorial Hospital
  - Washington D.C., District of Columbia, Forente stater, 20422
    - Veterans Affairs Medical Center - Washington, DC
- Florida
  - Gainesville, Florida, Forente stater, 32610-0277
    - University of Florida-Gainesville
  - Hollywood, Florida, Forente stater, 33021
    - Memorial Regional Hospital-Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Forente stater, 32224-9980
    - Mayo Clinic in Florida
  - Miami Beach, Florida, Forente stater, 33140
    - Mount Sinai Medical Center
  - Pembroke Pines, Florida, Forente stater, 33028
    - Memorial Hospital West
  - Stuart, Florida, Forente stater, 34994
    - Robert and Carol Weissman Cancer Center at Martin Health
- Georgia
  - Albany, Georgia, Forente stater, 31701
    - Phoebe Putney Memorial Hospital
  - Atlanta, Georgia, Forente stater, 30322
    - Emory University/Winship Cancer Institute
  - Decatur, Georgia, Forente stater, 30033
    - Dekalb Medical Center
  - Decatur, Georgia, Forente stater, 30033
    - Atlanta VA Medical Center
  - Gainesville, Georgia, Forente stater, 30501
    - Northeast Georgia Medical Center
  - Macon, Georgia, Forente stater, 31208
    - Medical Center of Central Georgia
  - Savannah, Georgia, Forente stater, 31405
    - Low Country Cancer Care Associates PC
- Hawaii
  - Honolulu, Hawaii, Forente stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forente stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forente stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forente stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forente stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forente stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Honolulu, Hawaii, Forente stater, 96859
    - Tripler Army Medical Center
  - Honolulu, Hawaii, Forente stater, 96817
    - Oncare Hawaii Inc-Kuakini
  - Honolulu, Hawaii, Forente stater, 96813
    - Oncare Hawaii Inc - POB II
  - ‘Aiea, Hawaii, Forente stater, 96701
    - Pali Momi Medical Center
- Idaho
  - Boise, Idaho, Forente stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forente stater, 83712
    - Saint Luke's Mountain States Tumor Institute
  - Fruitland, Idaho, Forente stater, 83619
    - Saint Luke's Mountain States Tumor Institute - Fruitland
  - Lewiston, Idaho, Forente stater, 83501
    - Saint Joseph Regional Medical Center
  - Meridian, Idaho, Forente stater, 83642
    - Saint Luke's Mountain States Tumor Institute - Meridian
  - Nampa, Idaho, Forente stater, 83686
    - Saint Luke's Mountain States Tumor Institute - Nampa
  - Twin Falls, Idaho, Forente stater, 83301
    - Saint Luke's Mountain States Tumor Institute-Twin Falls
- Illinois
  - Aurora, Illinois, Forente stater, 60504-4206
    - Rush Copley Medical Center
  - Bloomington, Illinois, Forente stater, 61701
    - Saint Joseph Medical Center
  - Bloomington, Illinois, Forente stater, 61701
    - Illinois CancerCare - Bloomington
  - Canton, Illinois, Forente stater, 61520
    - Illinois CancerCare - Canton
  - Carbondale, Illinois, Forente stater, 62902
    - Memorial Hospital of Carbondale
  - Carthage, Illinois, Forente stater, 62321
    - Illinois CancerCare - Carthage
  - Centralia, Illinois, Forente stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forente stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forente stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forente stater, 60640
    - Weiss Memorial Hospital
  - Chicago, Illinois, Forente stater, 60657
    - Advocate Illinois Masonic Medical Center
  - Chicago, Illinois, Forente stater, 60657
    - Presence Saint Joseph Hospital-Chicago
  - Chicago, Illinois, Forente stater, 60612-3785
    - John H. Stroger, Jr. Hospital of Cook County
  - Danville, Illinois, Forente stater, 61832
    - Carle on Vermilion
  - Decatur, Illinois, Forente stater, 62526
    - Cancer Care Specialists of Central Illinois
  - Decatur, Illinois, Forente stater, 62526
    - Decatur Memorial Hospital Cancer Care Institute
  - Effingham, Illinois, Forente stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forente stater, 62401
    - Carle Physician Group-Effingham
  - Elgin, Illinois, Forente stater, 60123
    - Advocate Sherman Hospital
  - Elmhurst, Illinois, Forente stater, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, Forente stater, 61530
    - Illinois CancerCare - Eureka
  - Evanston, Illinois, Forente stater, 60202
    - Saint Francis Hospital
  - Galesburg, Illinois, Forente stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forente stater, 61401
    - Illinois CancerCare - Galesburg
  - Harvey, Illinois, Forente stater, 60426
    - Ingalls Memorial Hospital
  - Highland Park, Illinois, Forente stater, 60035
    - Hematology Oncology Associates -Highland Park
  - Kankakee, Illinois, Forente stater, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Forente stater, 61443
    - Illinois CancerCare - Kewanee Clinic
  - Libertyville, Illinois, Forente stater, 60048
    - NorthShore Hematology Oncology-Libertyville
  - Macomb, Illinois, Forente stater, 61455
    - Illinois CancerCare - Macomb
  - Mattoon, Illinois, Forente stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Moline, Illinois, Forente stater, 61265
    - Garneau, Stewart C MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Spector, David MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Trinity Medical Center
  - Mount Vernon, Illinois, Forente stater, 62864
    - Good Samaritan Regional Health Center
  - Naperville, Illinois, Forente stater, 60540
    - Edward Hospital Cancer Center
  - Naperville, Illinois, Forente stater, 60540
    - Hematology Oncology Consultants Ltd.
  - Niles, Illinois, Forente stater, 60714
    - Illinois Cancer Specialists-Niles
  - Oak Lawn, Illinois, Forente stater, 60453-2699
    - Advocate Christ Medical Center
  - Ottawa, Illinois, Forente stater, 61350
    - Radiation Oncology of Northern Illinois
  - Pekin, Illinois, Forente stater, 61554
    - Pekin Cancer Treatment Center
  - Pekin, Illinois, Forente stater, 61603
    - Illinois CancerCare - Pekin
  - Peoria, Illinois, Forente stater, 61603
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forente stater, 61615
    - OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
  - Peru, Illinois, Forente stater, 61354
    - Valley Radiation Oncology
  - Peru, Illinois, Forente stater, 61354
    - Illinois CancerCare - Peru
  - Princeton, Illinois, Forente stater, 61356
    - Illinois CancerCare - Princeton
  - Quincy, Illinois, Forente stater, 62301
    - Quincy Medical Group - Clinic
  - Rockford, Illinois, Forente stater, 61108
    - OSF Saint Anthony Medical Center
  - Rockford, Illinois, Forente stater, 61104
    - Swedish American Hospital
  - Skokie, Illinois, Forente stater, 60076
    - Hematology Oncology Associates - Skokie
  - Springfield, Illinois, Forente stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forente stater, 62702
    - Central Illinois Hematology Oncology Center
  - Springfield, Illinois, Forente stater, 62703
    - Springfield Clinic
  - Springfield, Illinois, Forente stater, 62781-0001
    - Memorial Medical Center
  - Swansea, Illinois, Forente stater, 62226
    - Cancer Care Specialists of Illinois-Swansea
  - Urbana, Illinois, Forente stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forente stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forente stater, 60555
    - Cadence Cancer Center in Warrenville
- Indiana
  - Crown Point, Indiana, Forente stater, 46307
    - Michiana Hematology Oncology PC-Crown Point
  - Elkhart, Indiana, Forente stater, 46514
    - Michiana Hematology Oncology PC-Elkhart
  - Fishers, Indiana, Forente stater, 46037
    - IU Health Central Indiana Cancer Centers-Fishers
  - Indianapolis, Indiana, Forente stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Forente stater, 46219
    - IU Health Central Indiana Cancer Centers-East
  - Indianapolis, Indiana, Forente stater, 46202
    - IU Health Methodist Hospital
  - Indianapolis, Indiana, Forente stater, 46202
    - Indiana University - Melvin and Bren Simon Cancer Center
  - Lafayette, Indiana, Forente stater, 47904
    - IU Health Arnett Cancer Care
  - Michigan City, Indiana, Forente stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Mishawaka, Indiana, Forente stater, 46544
    - Memorial Regional Cancer Center Day Road
  - Mishawaka, Indiana, Forente stater, 46545
    - Michiana Hematology Oncology PC-Mishawaka
  - Mishawaka, Indiana, Forente stater, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Plymouth, Indiana, Forente stater, 46563
    - Michiana Hematology Oncology PC-Plymouth
  - South Bend, Indiana, Forente stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forente stater, 46601
    - Michiana Hematology Oncology PC-South Bend
  - South Bend, Indiana, Forente stater, 46628
    - Northern Indiana Cancer Research Consrtium
  - Westville, Indiana, Forente stater, 46391
    - Michiana Hematology Oncology PC-Westville
- Iowa
  - Ames, Iowa, Forente stater, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Forente stater, 50010
    - McFarland Clinic PC-William R Bliss Cancer Center
  - Bettendorf, Iowa, Forente stater, 52722
    - Constantinou, Costas L MD (UIA Investigator)
  - Bettendorf, Iowa, Forente stater, 52722
    - Hematology Oncology Associates - Quad Cities
  - Boone, Iowa, Forente stater, 50036
    - McFarland Clinic PC-Boone
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Physicians' Clinic of Iowa PC
  - Clive, Iowa, Forente stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forente stater, 50325
    - Medical Oncology and Hematology Associates - West Des Moines
  - Council Bluffs, Iowa, Forente stater, 51503
    - Alegent Health Mercy Hospital
  - Davenport, Iowa, Forente stater, 52803
    - Genesis Medical Center - East Campus
  - Des Moines, Iowa, Forente stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forente stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forente stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forente stater, 50309
    - Medical Oncology and Hematology Associates - Des Moines
  - Des Moines, Iowa, Forente stater, 50314
    - Medical Oncology and Hematology Associates-Laurel
  - Fairfield, Iowa, Forente stater, 52556
    - JCHC McCreery Cancer Center
  - Fort Dodge, Iowa, Forente stater, 50501
    - McFarland Clinic PC-Trinity Cancer Center
  - Jefferson, Iowa, Forente stater, 50129
    - McFarland Clinic PC-Jefferson
  - Marshalltown, Iowa, Forente stater, 50158
    - McFarland Clinic PC-Marshalltown
  - Mason City, Iowa, Forente stater, 50401
    - Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, Forente stater, 52501
    - Ottumwa Regional Health Center
  - Sioux City, Iowa, Forente stater, 51101
    - Siouxland Regional Cancer Center
  - West Des Moines, Iowa, Forente stater, 50266
    - Mercy Medical Center-West Lakes
  - West Des Moines, Iowa, Forente stater, 50266
    - Methodist West Hospital
- Kansas
  - Chanute, Kansas, Forente stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forente stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forente stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Fort Scott, Kansas, Forente stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Hays, Kansas, Forente stater, 67601
    - Hays Medical Center
  - Independence, Kansas, Forente stater, 67301
    - Cancer Center of Kansas - Independence
  - Kansas City, Kansas, Forente stater, 66112
    - Kansas City Cancer Centers - West
  - Kingman, Kansas, Forente stater, 67068
    - Cancer Center of Kansas - Kingman
  - Lawrence, Kansas, Forente stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forente stater, 67901
    - Cancer Center of Kansas - Liberal
  - Newton, Kansas, Forente stater, 67114
    - Cancer Center of Kansas - Newton
  - Overland Park, Kansas, Forente stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forente stater, 66213
    - Saint Luke's South Hospital
  - Overland Park, Kansas, Forente stater, 66210
    - Kansas City Cancer Centers - Southwest
  - Parsons, Kansas, Forente stater, 67357
    - Cancer Center of Kansas - Parsons
  - Prairie Village, Kansas, Forente stater, 66208
    - Kansas City NCI Community Oncology Research Program
  - Pratt, Kansas, Forente stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forente stater, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Forente stater, 66604
    - Stormont-Vail Regional Health Center
  - Wellington, Kansas, Forente stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forente stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forente stater, 67208
    - Cancer Center of Kansas - Wichita Medical Arts Tower
  - Wichita, Kansas, Forente stater, 67214
    - Cancer Center of Kansas - Main Office
  - Wichita, Kansas, Forente stater, 67214
    - Via Christi Regional Medical Center
  - Winfield, Kansas, Forente stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Bardstown, Kentucky, Forente stater, 40004
    - Flaget Memorial Hospital
  - Corbin, Kentucky, Forente stater, 40701
    - Commonwealth Cancer Center-Corbin
  - Corbin, Kentucky, Forente stater, 40704
    - Baptist Health Corbin
  - Crestview Hills, Kentucky, Forente stater, 41017
    - Oncology Hematology Care Inc-Crestview
  - Elizabethtown, Kentucky, Forente stater, 42701
    - Hardin Memorial Hospital
  - Lexington, Kentucky, Forente stater, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Forente stater, 40509
    - Saint Joseph Hospital East
  - Lexington, Kentucky, Forente stater, 40503
    - Baptist Health Lexington
  - Louisville, Kentucky, Forente stater, 40202
    - The James Graham Brown Cancer Center at University of Louisville
  - Louisville, Kentucky, Forente stater, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Forente stater, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Forente stater, 40215
    - Saints Mary and Elizabeth Hospital
  - Owensboro, Kentucky, Forente stater, 42303
    - Owensboro Health Mitchell Memorial Cancer Center
- Louisiana
  - Baton Rouge, Louisiana, Forente stater, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Mary Bird Perkins Cancer Center - Baton Rouge
  - Covington, Louisiana, Forente stater, 70433
    - Ochsner Health Center - Covington
  - Metairie, Louisiana, Forente stater, 70006
    - East Jefferson General Hospital
  - Monroe, Louisiana, Forente stater, 71210
    - Louisiana State University Health Sciences Center - Monroe
  - New Orleans, Louisiana, Forente stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forente stater, 70112
    - Louisiana State University Health Science Center
  - New Orleans, Louisiana, Forente stater, 70112
    - Interim LSU Public Hospital
  - Shreveport, Louisiana, Forente stater, 71130-3932
    - Louisiana State University Health Sciences Center - Shreveport
- Maine
  - Augusta, Maine, Forente stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forente stater, 04401
    - Eastern Maine Medical Center
  - Brewer, Maine, Forente stater, 04412
    - Eastern Maine Medical Center Cancer Care
  - Rockport, Maine, Forente stater, 04856
    - Penobscot Bay Medical Center
  - York Village, Maine, Forente stater, 03909
    - York Hospital
- Maryland
  - Baltimore, Maryland, Forente stater, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Forente stater, 21229
    - Saint Agnes Hospital
  - Baltimore, Maryland, Forente stater, 21133
    - Sinai Hospital of Baltimore
  - Cumberland, Maryland, Forente stater, 21502
    - Western Maryland Regional Medical Center
  - Frederick, Maryland, Forente stater, 21701
    - Frederick Memorial Hospital
  - Gaithersburg, Maryland, Forente stater, 20879
    - Kaiser Permanente - Gaithersburg Medical Center
  - Hagerstown, Maryland, Forente stater, 21742
    - Meritus Medical Center
  - Silver Spring, Maryland, Forente stater, 20910
    - Holy Cross Hospital
- Massachusetts
  - Beverly, Massachusetts, Forente stater, 01915
    - Beverly Hospital
  - Boston, Massachusetts, Forente stater, 02115
    - Brigham and Women's Hospital
  - Boston, Massachusetts, Forente stater, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Forente stater, 02115
    - Dana Farber Cancer Institute
  - Boston, Massachusetts, Forente stater, 02114
    - Massachusetts General Hospital Cancer Center
  - Burlington, Massachusetts, Forente stater, 01805
    - Lahey Hospital and Medical Center
  - Framingham, Massachusetts, Forente stater, 01702
    - MetroWest Medical Center-Framingham Union Hospital
  - Gloucester, Massachusetts, Forente stater, 01930
    - Addison Gilbert Hospital
  - Lowell, Massachusetts, Forente stater, 01854
    - Lowell General Hospital
  - Milford, Massachusetts, Forente stater, 01757
    - Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center
  - Newton, Massachusetts, Forente stater, 02462
    - Newton-Wellesley Hospital
  - Pittsfield, Massachusetts, Forente stater, 01201
    - Berkshire Hematology Oncology, PC
  - South Weymouth, Massachusetts, Forente stater, 02190
    - Dana-Farber/Brigham and Women's Cancer Center at South Shore
  - Worcester, Massachusetts, Forente stater, 01655
    - University of Massachusetts Medical School
- Michigan
  - Adrian, Michigan, Forente stater, 49221
    - Toledo Clinic Cancer Centers - Adrian
  - Ann Arbor, Michigan, Forente stater, 48106
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forente stater, 48109-0912
    - University Of Michigan Comprehensive Cancer Center
  - Battle Creek, Michigan, Forente stater, 49017
    - Bronson Battle Creek
  - Dearborn, Michigan, Forente stater, 48124
    - Oakwood Hospital and Medical Center
  - Detroit, Michigan, Forente stater, 48236
    - Saint John Hospital and Medical Center
  - Detroit, Michigan, Forente stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Escanaba, Michigan, Forente stater, 49431
    - Green Bay Oncology-Escanaba
  - Farmington, Michigan, Forente stater, 48336
    - Botsford Hospital
  - Flint, Michigan, Forente stater, 48503
    - Hurley Medical Center
  - Grand Rapids, Michigan, Forente stater, 49503
    - Spectrum Health at Butterworth Campus
  - Iron Mountain, Michigan, Forente stater, 49801
    - Green Bay Oncology-Iron Mountain
  - Jackson, Michigan, Forente stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forente stater, 49007-3731
    - West Michigan Cancer Center
  - Lansing, Michigan, Forente stater, 48912
    - Sparrow Hospital
  - Livonia, Michigan, Forente stater, 48154
    - Saint Mary Mercy Hospital
  - Monroe, Michigan, Forente stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Niles, Michigan, Forente stater, 49120
    - Lakeland Community Hospital
  - Pontiac, Michigan, Forente stater, 48341
    - Saint Joseph Mercy Oakland
  - Port Huron, Michigan, Forente stater, 48060
    - Saint Joseph Mercy Port Huron
  - Reed City, Michigan, Forente stater, 49677
    - Spectrum Health Reed City Hospital
  - Roseville, Michigan, Forente stater, 48066
    - Michigan Cancer Specialists
  - Royal Oak, Michigan, Forente stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Royal Oak, Michigan, Forente stater, 48067
    - Oakland Colon and Rectal Association
  - Royal Oak, Michigan, Forente stater, 48073
    - Cancer Care Associates PC
  - Royal Oak, Michigan, Forente stater, 48073
    - Comprehensive Medical Center PLLC
  - Royal Oak, Michigan, Forente stater, 48073
    - Oakland Medical Group
  - Royal Oak, Michigan, Forente stater, 48073
    - Hematology Oncology Consultants PC-Royal Oak
  - Saginaw, Michigan, Forente stater, 48601
    - Saint Mary's of Michigan
  - Saint Joseph, Michigan, Forente stater, 49085
    - Marie Yeager Cancer Center
  - Southfield, Michigan, Forente stater, 48075-9975
    - Providence Hospital - Southfield
  - Sterling Heights, Michigan, Forente stater, 48312
    - Premier Hematology Oncology Care
  - Sterling Heights, Michigan, Forente stater, 48314
    - Mitchell Folbe MD PC
  - Traverse City, Michigan, Forente stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forente stater, 48098
    - William Beaumont Hospital - Troy
  - Troy, Michigan, Forente stater, 48084
    - Michigan Institute of Urology-Town Center
  - Troy, Michigan, Forente stater, 48085
    - Claudia BR Herke MD PC
  - Troy, Michigan, Forente stater, 48098
    - Hematology Oncology Consultants PC-Troy
  - Warren, Michigan, Forente stater, 48093
    - Saint John Macomb-Oakland Hospital
- Minnesota
  - Bemidji, Minnesota, Forente stater, 56601
    - Sanford Clinic North-Bemidji
  - Burnsville, Minnesota, Forente stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forente stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forente stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forente stater, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, Forente stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forente stater, 55350
    - Hutchinson Area Health Care
  - Mankato, Minnesota, Forente stater, 56001
    - Mayo Clinic Health Systems-Mankato
  - Maplewood, Minnesota, Forente stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forente stater, 55109
    - Minnesota Oncology - Maplewood
  - Minneapolis, Minnesota, Forente stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forente stater, 55454
    - Health Partners Inc
  - Minneapolis, Minnesota, Forente stater, 55417
    - Minneapolis Veterans Medical Center
  - Minneapolis, Minnesota, Forente stater, 55102
    - Abbott-Northwestern Hospital
  - New Ulm, Minnesota, Forente stater, 56073
    - New Ulm Medical Center
  - Robbinsdale, Minnesota, Forente stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forente stater, 55905
    - Mayo Clinic Cancer Center
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forente stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forente stater, 55102
    - United Hospital
  - Shakopee, Minnesota, Forente stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forente stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forente stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forente stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forente stater, 55125
    - Minnesota Oncology - Woodbury
- Mississippi
  - Gulfport, Mississippi, Forente stater, 39502
    - Gulfport Memorial Hospital
  - Jackson, Mississippi, Forente stater, 39216-4505
    - University of Mississippi Medical Center
  - Pascagoula, Mississippi, Forente stater, 39581
    - Singing River Hospital
- Missouri
  - Bolivar, Missouri, Forente stater, 65613
    - Central Care Cancer Center - Carrie J Babb Cancer Center
  - Bonne Terre, Missouri, Forente stater, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Forente stater, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Southeast Cancer Center
  - City of Saint Peters, Missouri, Forente stater, 63376
    - Siteman Cancer Center - Saint Peters
  - Columbia, Missouri, Forente stater, 65212
    - University of Missouri - Ellis Fischel
  - Independence, Missouri, Forente stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forente stater, 65109
    - Capital Region Medical Center-Goldschmidt Cancer Center
  - Joplin, Missouri, Forente stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forente stater, 64804
    - Mercy Hospital-Joplin
  - Kansas City, Missouri, Forente stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forente stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forente stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forente stater, 64108
    - Truman Medical Center
  - Kansas City, Missouri, Forente stater, 64154
    - Kansas City Cancer Centers - North
  - Kansas City, Missouri, Forente stater, 64118
    - Heartland Hematology Oncology Associates, Incorporated
  - Kansas City, Missouri, Forente stater, 64131
    - Kansas City Cancer Centers - South
  - Lee's Summit, Missouri, Forente stater, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Forente stater, 64068
    - Liberty Radiation Oncology Center
  - Rolla, Missouri, Forente stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla, Missouri, Forente stater, 65401
    - Phelps County Regional Medical Center
  - Saint Joseph, Missouri, Forente stater, 64506
    - Heartland Regional Medical Center
  - Saint Joseph, Missouri, Forente stater, 49085
    - Lakeland Hospital
  - Sainte Genevieve, Missouri, Forente stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forente stater, 65804
    - Mercy Hospital Springfield
  - Springfield, Missouri, Forente stater, 65807
    - Cox Health South Hospital
  - St Louis, Missouri, Forente stater, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Forente stater, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Forente stater, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Forente stater, 63141
    - Barnes-Jewish West County Hospital
  - St Louis, Missouri, Forente stater, 63109
    - Saint Louis Cancer and Breast Institute - South City
  - Sullivan, Missouri, Forente stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forente stater, 63127
    - Missouri Baptist Outpatient Center-Sunset Hills
- Montana
  - Billings, Montana, Forente stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forente stater, 59107
    - Billings Clinic Cancer Center
  - Billings, Montana, Forente stater, 59101
    - Montana Cancer Consortium NCORP
  - Bozeman, Montana, Forente stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forente stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forente stater, 59405
    - Benefis Healthcare - Sletten Cancer Institute
  - Helena, Montana, Forente stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forente stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forente stater, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Grand Island, Nebraska, Forente stater, 68803
    - CHI Health Saint Francis
  - Kearney, Nebraska, Forente stater, 68847
    - CHI Health Good Samaritan
  - Kearney, Nebraska, Forente stater, 68845
    - Heartland Hematology and Oncology
  - Lincoln, Nebraska, Forente stater, 68510
    - Nebraska Cancer Research Center
  - Lincoln, Nebraska, Forente stater, 68510
    - Saint Elizabeth Regional Medical Center
  - North Platte, Nebraska, Forente stater, 69101
    - Great Plains Regional Medical Center
  - Omaha, Nebraska, Forente stater, 68198-7680
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forente stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forente stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forente stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forente stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forente stater, 68122
    - Hematology and Oncology Consultants PC
  - Omaha, Nebraska, Forente stater, 68106
    - Missouri Valley Cancer Consortium CCOP
  - Omaha, Nebraska, Forente stater, 68114
    - Oncology Hematology West, P.C.
  - Omaha, Nebraska, Forente stater, 68131-2197
    - Creighton University Cancer Center
  - Papillion, Nebraska, Forente stater, 68046
    - Midlands Community Hospital
- Nevada
  - Henderson, Nevada, Forente stater, 89074
    - 21st Century Oncology-Henderson
  - Las Vegas, Nevada, Forente stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forente stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forente stater, 89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas, Nevada, Forente stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forente stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forente stater, 89106
    - Cancer and Blood Specialists-Henderson
  - Las Vegas, Nevada, Forente stater, 89109
    - 21st Century Oncology
  - Las Vegas, Nevada, Forente stater, 89128
    - 21st Century Oncology-Vegas Tenaya
  - Las Vegas, Nevada, Forente stater, 89128
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forente stater, 89148
    - 21st Century Oncology-Fort Apache
  - Las Vegas, Nevada, Forente stater, 89148
    - Cancer and Blood Specialists-Fort Apache
- New Hampshire
  - Concord, New Hampshire, Forente stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Dover, New Hampshire, Forente stater, 03820
    - Wentworth Douglass Hospital
  - Hooksett, New Hampshire, Forente stater, 03106
    - New Hampshire Oncology-Hematology, PA - Hooksett
  - Laconia, New Hampshire, Forente stater, 03246
    - LRGHealthcare-Lakes Region General Hospital
  - Lebanon, New Hampshire, Forente stater, 03756
    - Dartmouth Hitchcock Medical Center
  - Manchester, New Hampshire, Forente stater, 03102
    - Norris Cotton Cancer Center-Manchester
- New Jersey
  - Camden, New Jersey, Forente stater, 08103
    - Cooper Hospital University Medical Center
  - East Orange, New Jersey, Forente stater, 07018
    - Veterans Administration New Jersey Health Care System
  - Livingston, New Jersey, Forente stater, 07039
    - Saint Barnabas Medical Center
  - Long Branch, New Jersey, Forente stater, 07740
    - Monmouth Medical Center
  - Mount Holly, New Jersey, Forente stater, 08060
    - Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
  - Newark, New Jersey, Forente stater, 07112
    - Newark Beth Israel Medical Center
  - Somerville, New Jersey, Forente stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Vineland, New Jersey, Forente stater, 08360
    - Inspira Medical Center Vineland
  - Voorhees Township, New Jersey, Forente stater, 08043
    - Virtua West Jersey Hospital Voorhees
  - Woodbury, New Jersey, Forente stater, 08096
    - Inspira Medical Center Woodbury
- New Mexico
  - Albuquerque, New Mexico, Forente stater, 87102
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forente stater, 87102
    - Lovelace Medical Center - Downtown
  - Albuquerque, New Mexico, Forente stater, 87108
    - Lovelace Medical Center at Lovelace Sandia Health System
  - Las Cruces, New Mexico, Forente stater, 88011
    - Memorial Medical Center-Las Cruces
- New York
  - Elmhurst, New York, Forente stater, 11373
    - Elmhurst Hospital Center
  - Elmira, New York, Forente stater, 14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - Glens Falls, New York, Forente stater, 12801
    - Glens Falls Hospital
  - Jamaica, New York, Forente stater, 11432
    - Queens Hospital Center
  - Manhasset, New York, Forente stater, 11030
    - North Shore University Hospital
  - New Hyde Park, New York, Forente stater, 11040
    - North Shore-LIJ Health System/Center for Advanced Medicine
  - New York, New York, Forente stater, 10065
    - Weill Medical College of Cornell University
  - New York, New York, Forente stater, 10003
    - Beth Israel Medical Center
  - New York, New York, Forente stater, 10025
    - Saint Luke's Roosevelt Hospital Center - Saint Luke's Division
  - Rochester, New York, Forente stater, 14642
    - University of Rochester
  - Rochester, New York, Forente stater, 14621
    - Rochester General Hospital
  - Staten Island, New York, Forente stater, 10305
    - Staten Island University Hospital
  - Stony Brook, New York, Forente stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forente stater, 13210
    - State University of New York - Upstate Medical University
  - The Bronx, New York, Forente stater, 10461
    - Albert Einstein College of Medicine
  - The Bronx, New York, Forente stater, 10467
    - Montefiore Medical Center - Moses Campus
  - Utica, New York, Forente stater, 13502
    - Faxton-Saint Luke's Healthcare
- North Carolina
  - Asheboro, North Carolina, Forente stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forente stater, 28816
    - Hope Women's Cancer Centers-Asheville
  - Asheville, North Carolina, Forente stater, 28801
    - Cancer Care of Western North Carolina
  - Asheville, North Carolina, Forente stater, 28801
    - Mission Hospital-Memorial Campus
  - Asheville, North Carolina, Forente stater, 28801
    - Mountain Radiation Oncology
  - Brevard, North Carolina, Forente stater, 28612
    - Transylvania Regional Hospital
  - Chapel Hill, North Carolina, Forente stater, 27599
    - University of North Carolina at Chapel Hill
  - Charlotte, North Carolina, Forente stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Clinton, North Carolina, Forente stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Durham, North Carolina, Forente stater, 27710
    - Duke University Medical Center
  - Franklin, North Carolina, Forente stater, 28744
    - Angel Medical Center
  - Goldsboro, North Carolina, Forente stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forente stater, 27534
    - Wayne Memorial Hospital
  - Henderson, North Carolina, Forente stater, 27536
    - Maria Parham Medical Center
  - Hendersonville, North Carolina, Forente stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville, North Carolina, Forente stater, 28792
    - Park Ridge Health
  - Jacksonville, North Carolina, Forente stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Jacksonville, North Carolina, Forente stater, 28546
    - Onslow Memorial Hospital
  - Kinston, North Carolina, Forente stater, 28501
    - Kinston Medical Specialists PA
  - Lumberton, North Carolina, Forente stater, 28359
    - Southeastern Regional Medical Center
  - Marion, North Carolina, Forente stater, 28754
    - McDowell Hospital
  - Raleigh, North Carolina, Forente stater, 27609
    - Duke Raleigh Hospital
  - Raleigh, North Carolina, Forente stater, 27607
    - Rex Cancer Center
  - Raleigh, North Carolina, Forente stater, 27614
    - Rex Cancer Center of Wakefield
  - Reidsville, North Carolina, Forente stater, 27320
    - Annie Penn Memorial Hospital
  - Spruce Pine, North Carolina, Forente stater, 28777
    - Blue Ridge Regional Hospital
  - Statesville, North Carolina, Forente stater, 28677
    - Iredell Memorial Hospital
  - Wilmington, North Carolina, Forente stater, 28402-9025
    - New Hanover Regional Medical Center
  - Winston-Salem, North Carolina, Forente stater, 27157
    - Wake Forest University Health Sciences
- North Dakota
  - Bismarck, North Dakota, Forente stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Forente stater, 58102
    - Sanford Clinic North-Fargo
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Medical Center-Fargo
  - Minot, North Dakota, Forente stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Forente stater, 44304
    - Summa Akron City Hospital/Cooper Cancer Center
  - Akron, Ohio, Forente stater, 44307
    - Akron General Medical Center
  - Barberton, Ohio, Forente stater, 44203
    - Summa Barberton Hospital
  - Beachwood, Ohio, Forente stater, 44122
    - Cleveland Clinic Cancer Center Beachwood
  - Belpre, Ohio, Forente stater, 45714
    - Strecker Cancer Center-Belpre
  - Canton, Ohio, Forente stater, 44710
    - Aultman Health Foundation
  - Centerville, Ohio, Forente stater, 45459
    - Miami Valley Hospital South
  - Chillicothe, Ohio, Forente stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forente stater, 45267
    - University of Cincinnati
  - Cincinnati, Ohio, Forente stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forente stater, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Forente stater, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati, Ohio, Forente stater, 45202
    - Oncology Hematology Care Inc-Eden Park
  - Cincinnati, Ohio, Forente stater, 45211
    - Oncology Hematology Care Inc-Mercy West
  - Cincinnati, Ohio, Forente stater, 45230
    - Oncology Hematology Care Inc-Anderson
  - Cincinnati, Ohio, Forente stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Forente stater, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Forente stater, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Forente stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forente stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forente stater, 44111
    - Cleveland Clinic Cancer Center at Fairview Hospital
  - Cleveland, Ohio, Forente stater, 44106
    - Case Western Reserve Center
  - Columbus, Ohio, Forente stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forente stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forente stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forente stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forente stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forente stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forente stater, 43215
    - Columbus NCI Community Oncology Research Program
  - Columbus, Ohio, Forente stater, 43213
    - Mount Carmel Hospital East
  - Dayton, Ohio, Forente stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forente stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forente stater, 45420
    - Dayton NCI Community Oncology Research Program
  - Dayton, Ohio, Forente stater, 45428
    - Veteran Affairs Medical Center
  - Delaware, Ohio, Forente stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forente stater, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Forente stater, 43015
    - Grady Memorial Hospital
  - Fairfield, Ohio, Forente stater, 45014
    - Oncology Hematology Care Inc-Healthplex
  - Findlay, Ohio, Forente stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forente stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Greenville, Ohio, Forente stater, 45331
    - Wayne Hospital
  - Independence, Ohio, Forente stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kettering, Ohio, Forente stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forente stater, 43130
    - Fairfield Medical Center
  - Mansfield, Ohio, Forente stater, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Marietta, Ohio, Forente stater, 45750
    - Marietta Memorial Hospital
  - Maumee, Ohio, Forente stater, 43537-1839
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Oncology Center
  - Mayfield Heights, Ohio, Forente stater, 44124
    - Hillcrest Hospital Cancer Center
  - Mount Vernon, Ohio, Forente stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forente stater, 43055
    - Newark Radiation Oncology
  - Oregon, Ohio, Forente stater, 43616
    - Saint Charles Hospital
  - Portsmouth, Ohio, Forente stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forente stater, 44870
    - North Coast Cancer Care
  - Springfield, Ohio, Forente stater, 45505
    - Springfield Regional Medical Center
  - Steubenville, Ohio, Forente stater, 43952
    - Trinity's Tony Teramana Cancer Center
  - Strongsville, Ohio, Forente stater, 44136
    - Cleveland Clinic Foundation - Strongsville
  - Sylvania, Ohio, Forente stater, 43560
    - Flower Hospital
  - Toledo, Ohio, Forente stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Troy, Ohio, Forente stater, 45373
    - Upper Valley Medical Center
  - Warrensville Heights, Ohio, Forente stater, 44122
    - South Pointe Hospital
  - Westerville, Ohio, Forente stater, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Forente stater, 44145
    - UHHS Westlake Medical Center
  - Wooster, Ohio, Forente stater, 44691
    - Cleveland Clinic - Wooster Specialty Center
  - Zanesville, Ohio, Forente stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Norman, Oklahoma, Forente stater, 73071
    - Mercy Clinic Oklahoma Communities Inc-Norman
  - Oklahoma City, Oklahoma, Forente stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forente stater, 73120
    - Mercy Hospital Oklahoma City
  - Tulsa, Oklahoma, Forente stater, 74146
    - Tulsa Cancer Institute
- Oregon
  - Bend, Oregon, Forente stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forente stater, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Forente stater, 97015
    - Providence Oncology and Hematology Care Southeast
  - Gresham, Oregon, Forente stater, 97030
    - Legacy Mount Hood Medical Center
  - Newberg, Oregon, Forente stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forente stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forente stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forente stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forente stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forente stater, 97225
    - Providence Saint Vincent Medical Center
  - Tualatin, Oregon, Forente stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Abington, Pennsylvania, Forente stater, 19001
    - Abington Memorial Hospital
  - Allentown, Pennsylvania, Forente stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Beaver, Pennsylvania, Forente stater, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem, Pennsylvania, Forente stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bethlehem, Pennsylvania, Forente stater, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Bryn Mawr, Pennsylvania, Forente stater, 19010
    - Bryn Mawr Hospital
  - Danville, Pennsylvania, Forente stater, 17822
    - Geisinger Medical Center
  - Easton, Pennsylvania, Forente stater, 18042
    - Easton Hospital
  - Gettysburg, Pennsylvania, Forente stater, 17325
    - Adams Cancer Center
  - Greensburg, Pennsylvania, Forente stater, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Hanover, Pennsylvania, Forente stater, 17331
    - Cherry Tree Cancer Center
  - Harrisburg, Pennsylvania, Forente stater, 17105
    - PinnacleHealth Regional Cancer Center at Polyclinic Hospital
  - Johnstown, Pennsylvania, Forente stater, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Lewistown, Pennsylvania, Forente stater, 17044
    - Lewistown Hospital
  - McKeesport, Pennsylvania, Forente stater, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Monroeville, Pennsylvania, Forente stater, 15146
    - Forbes Hospital
  - Moon Township, Pennsylvania, Forente stater, 15108
    - UPMC-Coraopolis/Heritage Valley Radiation Oncology
  - Paoli, Pennsylvania, Forente stater, 19301
    - Paoli Memorial Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pittsburgh, Pennsylvania, Forente stater, 15232
    - UPMC-Shadyside Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15213
    - UPMC-Presbyterian Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Forente stater, 15236
    - UPMC Jefferson Regional Radiation Oncology
  - Pittsburgh, Pennsylvania, Forente stater, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pottstown, Pennsylvania, Forente stater, 19464
    - Pottstown Memorial Regional Cancer Center
  - Pottsville, Pennsylvania, Forente stater, 17901
    - Geisinger Medical Oncology-Pottsville
  - Scranton, Pennsylvania, Forente stater, 18510
    - Scranton Hematology-Oncology
  - Sellersville, Pennsylvania, Forente stater, 18960
    - Grand View Hospital
  - Seneca, Pennsylvania, Forente stater, 16346
    - UPMC Cancer Center at UPMC Northwest
  - State College, Pennsylvania, Forente stater, 16801
    - Geisinger Medical Group
  - State College, Pennsylvania, Forente stater, 16803
    - Mount Nittany Medical Center
  - Uniontown, Pennsylvania, Forente stater, 15401
    - UPMC Uniontown Hospital Radiation Oncology
  - Washington, Pennsylvania, Forente stater, 15301
    - UPMC Washington Hospital Radiation Oncology
  - West Chester, Pennsylvania, Forente stater, 19380
    - Chester County Hospital
  - West Grove, Pennsylvania, Forente stater, 19390-9499
    - Jennersville Regional Hospital
  - West Reading, Pennsylvania, Forente stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forente stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forente stater, 17701
    - Susquehanna Cancer Center at Divine Providence Hospital
  - York, Pennsylvania, Forente stater, 17405
    - WellSpan Health-York Hospital
  - York, Pennsylvania, Forente stater, 17403
    - Wellspan Health - York Cancer Center
- Rhode Island
  - Pawtucket, Rhode Island, Forente stater, 02860
    - Memorial Hospital of Rhode Island
  - Providence, Rhode Island, Forente stater, 02903
    - Rhode Island Hospital
  - Providence, Rhode Island, Forente stater, 02906
    - Miriam Hospital
- South Carolina
  - Anderson, South Carolina, Forente stater, 29621
    - AnMed Health Cancer Center
  - Charleston, South Carolina, Forente stater, 29425
    - Medical University of South Carolina
  - Easley, South Carolina, Forente stater, 29640
    - Greenville Health System Cancer Institute-Easley
  - Greenville, South Carolina, Forente stater, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Health System Cancer Institute - Butternut
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Health System Cancer Institute-Faris
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Memorial Hospital
  - Greenville, South Carolina, Forente stater, 29615
    - Greenville Health System Cancer Institute-Eastside
  - Greer, South Carolina, Forente stater, 29651
    - Gibbs Cancer Center-Pelham
  - Greer, South Carolina, Forente stater, 29650
    - Greenville Health System Cancer Institute-Greer
  - Lancaster, South Carolina, Forente stater, 29720
    - Carolina Blood and Cancer Care Associates, PA
  - Rock Hill, South Carolina, Forente stater, 29732
    - Carolina Blood and Cancer Care
  - Seneca, South Carolina, Forente stater, 29672
    - Greenville Health System Cancer Institute-Seneca
  - Spartanburg, South Carolina, Forente stater, 29303
    - Spartanburg Medical Center
  - Spartanburg, South Carolina, Forente stater, 29307
    - Greenville Health System Cancer Institute - Spartanburg
- South Dakota
  - Aberdeen, South Dakota, Forente stater, 57401
    - Avera Saint Luke's Hospital and Cancer Center
  - Rapid City, South Dakota, Forente stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forente stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forente stater, 57104
    - Sanford Cancer Center Oncology Clinic
  - Sioux Falls, South Dakota, Forente stater, 57117
    - Sanford USD Medical Center - Sioux Falls
- Tennessee
  - Bristol, Tennessee, Forente stater, 37620
    - Wellmont Medical Associates-Oncology and Hematology
  - Hixson, Tennessee, Forente stater, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Kingsport, Tennessee, Forente stater, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Knoxville, Tennessee, Forente stater, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, Forente stater, 37920
    - University of Tennessee - Knoxville
  - Nashville, Tennessee, Forente stater, 37203
    - Tennessee Oncology PLLC- Centennial Medical Center
  - Ooltewah, Tennessee, Forente stater, 37363
    - Memorial GYN Plus
- Texas
  - Houston, Texas, Forente stater, 77030
    - M D Anderson Cancer Center
  - Houston, Texas, Forente stater, 77030
    - Baylor College of Medicine
  - Houston, Texas, Forente stater, 77030
    - Ben Taub General Hospital
  - Houston, Texas, Forente stater, 77026
    - Lyndon Baines Johnson General Hospital
  - San Antonio, Texas, Forente stater, 78229-3900
    - University of Texas Health Science Center at San Antonio
  - San Antonio, Texas, Forente stater, 78229
    - University Hospital - San Antonio
  - Temple, Texas, Forente stater, 76508
    - Scott and White Memorial Hospital
- Vermont
  - Berlin Corners, Vermont, Forente stater, 05602
    - Central Vermont Medical Center
  - Burlington, Vermont, Forente stater, 05405
    - University of Vermont College of Medicine
  - Saint Johnsbury, Vermont, Forente stater, 05819
    - Norris Cotton Cancer Center-North
  - White River Junction, Vermont, Forente stater, 05009
    - White River Junction Veteran Administration Medical Center
- Virginia
  - Fairfax, Virginia, Forente stater, 22031
    - Medical Oncology Hematology Associates of Northern Virginia Limited
  - Hampton, Virginia, Forente stater, 23666
    - Virginia Oncology Associates - Hampton
  - Martinsville, Virginia, Forente stater, 24115
    - Memorial Hospital Of Martinsville
  - Midlothian, Virginia, Forente stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Norton, Virginia, Forente stater, 24273
    - Southwest VA Regional Cancer Center
  - Richmond, Virginia, Forente stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forente stater, 23226
    - Bon Secours Saint Mary's Hospital
  - Richmond, Virginia, Forente stater, 23230
    - Virginia Cancer Institute - West End
  - South Hill, Virginia, Forente stater, 23970
    - VCU Community Memorial Health Center
- Washington
  - Anacortes, Washington, Forente stater, 98221
    - Cancer Care Center at Island Hospital
  - Auburn, Washington, Forente stater, 98001
    - MultiCare Auburn Medical Center
  - Bainbridge Island, Washington, Forente stater, 98110
    - Virginia Mason Bainbridge Island Medical Center
  - Bellevue, Washington, Forente stater, 98004
    - Overlake Hospital Medical Center
  - Bellingham, Washington, Forente stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forente stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Bremerton, Washington, Forente stater, 98310
    - Harrison Medical Center
  - Burien, Washington, Forente stater, 98166
    - Highline Medical Center-Main Campus
  - Edmonds, Washington, Forente stater, 98026
    - Swedish Medical Center-Edmonds
  - Enumclaw, Washington, Forente stater, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Forente stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forente stater, 98002
    - Virginia Mason Federal Way Medical Center
  - Federal Way, Washington, Forente stater, 98003
    - Saint Francis Hospital
  - Gig Harbor, Washington, Forente stater, 98332
    - Tacoma/Valley Radiation Oncology Centers-Gig Harbor
  - Gig Harbor, Washington, Forente stater, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Forente stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forente stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kennewick, Washington, Forente stater, 99336
    - Northwest Cancer Clinic
  - Kirkland, Washington, Forente stater, 98034
    - Seattle Cancer Care Alliance at EvergreenHealth
  - Lakewood, Washington, Forente stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forente stater, 98632
    - Saint John Medical Center
  - Lynnwood, Washington, Forente stater, 98036
    - Virginia Mason Lynnwood Medical Center
  - Mount Vernon, Washington, Forente stater, 98274
    - Skagit Valley Hospital
  - Poulsbo, Washington, Forente stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Poulsbo, Washington, Forente stater, 98370
    - Peninsula Cancer Center
  - Puyallup, Washington, Forente stater, 98372
    - MultiCare Good Samaritan Hospital
  - Puyallup, Washington, Forente stater, 98372
    - Tacoma/Valley Radiation Oncology Centers-Puyallup
  - Seattle, Washington, Forente stater, 98109
    - Seattle Cancer Care Alliance
  - Seattle, Washington, Forente stater, 98195
    - University of Washington Medical Center
  - Seattle, Washington, Forente stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forente stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forente stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forente stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forente stater, 98112
    - Group Health Cooperative-Seattle
  - Spokane, Washington, Forente stater, 99218
    - Evergreen Hematology and Oncology PS
  - Spokane, Washington, Forente stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forente stater, 99216
    - Cancer Care Northwest-Valley
  - Spokane, Washington, Forente stater, 98109
    - Cancer Care Northwest-North Spokane
  - Tacoma, Washington, Forente stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forente stater, 98405
    - Tacoma/Valley Radiation Oncology Centers-Saint Joe's
  - Tacoma, Washington, Forente stater, 97405
    - Tacoma/Valley Radiation Oncology Centers-Jackson Hall
  - Tacoma, Washington, Forente stater, 98405
    - Northwest NCI Community Oncology Research Program
  - Tacoma, Washington, Forente stater, 98415
    - MultiCare Health System
  - Tacoma, Washington, Forente stater, 98431
    - Madigan Army Medical Center - Tacoma
  - Tacoma, Washington, Forente stater, 98405
    - Franciscan Research Center - Northwest Medical Plaza
  - Vancouver, Washington, Forente stater, 98686
    - Legacy Salmon Creek Hospital
  - Vancouver, Washington, Forente stater, 98664
    - PeaceHealth Southwest Medical Center
  - Wenatchee, Washington, Forente stater, 98801
    - Wenatchee Valley Hospital and Clinics
  - Yakima, Washington, Forente stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- West Virginia
  - Huntington, West Virginia, Forente stater, 25701
    - Edwards Comprehensive Cancer Center
  - Princeton, West Virginia, Forente stater, 24740
    - Princeton Community Hospital
- Wisconsin
  - Appleton, Wisconsin, Forente stater, 54911-3496
    - Fox Valley Hematology and Oncology
  - Burlington, Wisconsin, Forente stater, 53105
    - Aurora Cancer Care-Burlington
  - Eau Claire, Wisconsin, Forente stater, 54701
    - Mayo Clinic Health System-Eau Claire Clinic
  - Eau Claire, Wisconsin, Forente stater, 54703
    - Mayo Clinic Health System Eau Claire Hospital-Luther Campus
  - Eau Claire, Wisconsin, Forente stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Elkhorn, Wisconsin, Forente stater, 53121
    - Aurora Cancer Care-Southern Lakes
  - Grafton, Wisconsin, Forente stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forente stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forente stater, 54301
    - Saint Vincent Hospital
  - Green Bay, Wisconsin, Forente stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forente stater, 54303
    - Saint Mary's Hospital
  - Green Bay, Wisconsin, Forente stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Johnson Creek, Wisconsin, Forente stater, 53038
    - UW Cancer Center Johnson Creek
  - Kenosha, Wisconsin, Forente stater, 53142
    - Aurora Cancer Care-Kenosha South
  - Madison, Wisconsin, Forente stater, 53792
    - University of Wisconsin Hospital and Clinics
  - Manitowoc, Wisconsin, Forente stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forente stater, 54143
    - Bay Area Medical Center
  - Marinette, Wisconsin, Forente stater, 54143
    - Vince Lombardi Cancer Clinic - Marinette
  - Marshfield, Wisconsin, Forente stater, 54449
    - Marshfield Clinic
  - Menomonee Falls, Wisconsin, Forente stater, 53051
    - Aurora Advanced Healthcare Inc-Menomonee Falls
  - Milwaukee, Wisconsin, Forente stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forente stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53233
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53210
    - Wheaton Franciscan Healthcare - St. Joseph
  - Minocqua, Wisconsin, Forente stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Mukwonago, Wisconsin, Forente stater, 53149
    - D N Greenwald Center
  - New Richmond, Wisconsin, Forente stater, 54017
    - Westfields Hospital/Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Forente stater, 53066
    - Oconomowoc Memorial Hospital-ProHealth Care Inc
  - Oconto Falls, Wisconsin, Forente stater, 54154
    - Green Bay Oncology - Oconto Falls
  - Oshkosh, Wisconsin, Forente stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forente stater, 53406-5661
    - Aurora Cancer Care-Racine
  - Rhinelander, Wisconsin, Forente stater, 54501
    - Marshfield Clinic at James Beck Cancer Center
  - Rice Lake, Wisconsin, Forente stater, 54868
    - Marshfield Clinic-Rice Lake Center
  - Sheboygan, Wisconsin, Forente stater, 53081
    - Saint Nicholas Hospital
  - Sheboygan, Wisconsin, Forente stater, 53081
    - Vince Lombardi Cancer Clinic - Sheboygan
  - Stevens Point, Wisconsin, Forente stater, 54481
    - Marshfield Clinic Cancer Care at Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forente stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Summit, Wisconsin, Forente stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forente stater, 54241
    - Vince Lombardi Cancer Clinic - Two Rivers
  - Waukesha, Wisconsin, Forente stater, 53188
    - Aurora Cancer Care-Waukesha
  - Waukesha, Wisconsin, Forente stater, 53188
    - Waukesha Memorial Hospital
  - Wausau, Wisconsin, Forente stater, 54401
    - Aspirus Regional Cancer Center
  - Wauwatosa, Wisconsin, Forente stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forente stater, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Forente stater, 54476
    - Diagnostic and Treatment Center
  - Weston, Wisconsin, Forente stater, 54476
    - Marshfield Clinic - Weston Center
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Cheyenne, Wyoming, Forente stater, 82001
    - Cheyenne Regional Medical Center-West
  - Sheridan, Wyoming, Forente stater, 82801
    - Welch Cancer Center
Puerto Rico
- - San Juan, Puerto Rico, 00936
    - San Juan City Hospital

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Beskrivelse

Krav til tumorparametere
1. Histologisk dokumentert adenokarsinom i tykktarmen. Den brutto nedre (caudad) marginen til primærtumoren må ligge over peritonealrefleksjonen (dvs. pasienter med endetarmskreft er ikke kvalifisert). Kirurgbekreftelse på at hele svulsten var over peritonealrefleksjonen er kun nødvendig i tilfeller hvor det er viktig å fastslå om svulsten er en rektal eller tykktarms primær.
2. Tumorer må ha blitt fullstendig resekert. Hos pasienter med tumor adherent til tilstøtende strukturer skal en bloc R0 reseksjon dokumenteres i operasjonsrapporten eller på annen måte bekreftes av kirurgen. Nær eller positiv radiell margin er ikke utelukkelser så lenge en bloc reseksjon ble utført. Positiv proksimal margin eller distal margin er en eksklusjon.
3. Nodepositiv sykdom (N1 eller N2) som angitt i AJCC versjon 7. Enten minst én patologisk bekreftet positiv lymfeknute eller N1C (definert som tumoravsetning(er) i subserosa, mesenterium eller ikke-peritonealisert perikolsk eller perirektalt vev uten regional lymfeknute metastaser). Pasienter med reseksjonert stadium IV sykdom er ikke kvalifisert.
4. Ingen bevis for gjenværende involvert lymfeknutesykdom eller metastatisk sykdom på registreringstidspunktet.
5. Pasienter med synkron tykktarmskreft er kvalifisert og stadieinndeling for stratifisering vil være basert på høyere N-stadium av den mer avanserte primærtumoren. Pasienter med synkrone tykktarms- og rektale primærtumorer er imidlertid ikke kvalifisert.
NSAID-bruk
Pasienter er ikke kvalifisert hvis de planlegger regelmessig bruk av NSAIDs i en hvilken som helst dose mer enn 2 ganger per uke (i gjennomsnitt) eller aspirin med mer enn 325 mg minst tre ganger per uke i gjennomsnitt. Lavdose aspirin som ikke overstiger 100 mg/dag er tillatt. Pasienter som samtykker i å slutte med vanlige NSAIDs eller høyere doser aspirin er kvalifisert og ingen var ute-periode er nødvendig.
Pasienthistorie
1. Ingen tidligere eller samtidig malignitet, bortsett fra behandlet basalcelle- eller plateepitelkreft i hud, behandlet in situ livmorhalskreft, behandlet lobulært eller ductalt karsinom in situ i ett bryst, eller annen kreft som pasienten har vært sykdomsfri for i minst 5 år.
2. Ingen nevrosensorisk eller nevromotorisk toksisitet ≥ grad 2 ved registreringstidspunktet.
3. Ingen kjent allergi mot platinaforbindelser.
4. Ingen tidligere allergisk reaksjon eller overfølsomhet overfor sulfonamider, celecoxib eller NSAIDs.
5. Ingen historie med øvre gastrointestinal sårdannelse, øvre gastrointestinal blødning eller øvre gastrointestinal perforasjon i løpet av de siste 3 årene. Pasienter med sårdannelse, blødning eller perforasjon i nedre tarm er ikke ekskludert.
6. Ingen symptomatisk lungefibrose eller interstitiell pneumonitt ≥ grad 2.
7. Ingen hjerterisikofaktorer inkludert:
  - Ukontrollert høyt blodtrykk (systolisk blodtrykk > 150).
  - Ustabil angina.
  - Anamnese med dokumentert hjerteinfarkt eller cerebrovaskulær ulykke.
  - New York Heart Association klasse III eller IV hjertesvikt.
Graviditet/sykepleiestatus
Ikke gravid og ikke ammende. Menn og kvinner i fertil alder må samtykke i å bruke adekvat prevensjon under cellegiftbehandlingen og i så mange som 8 uker etter fullført cellegift på grunn av de ukjente teratogene effektene av FOLFOX på fosteret i utvikling.
Alder og prestasjonsstatus
1. ECOG ytelsesstatus 0, 1 eller 2.
2. Alder minst 18 år.
Nødvendige innledende laboratorieverdier
1. Granulocytter ≥ 1500/μL
2. Blodplateantall ≥ 100 000/μL
3. Kreatinin ≤ 1,5 ganger øvre normalgrense (ULN)
4. Totalt bilirubin ≤ 1,5 ganger ULN i fravær av Gilberts sykdom
5. Direkte bilirubin ≤ 1,5 x øvre normalgrense for pasienter med Gilberts syndrom

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Primært formål: Behandling
Tildeling: Randomisert
Intervensjonsmodell: Parallell tildeling
Masking: Dobbelt

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm	Intervensjon / Behandling
Aktiv komparator: Arm A - FOLFOX og placebo (12 behandlinger) Pasienter får FOLFOX hver 2. uke pluss placebo hver dag i 12 behandlinger (24 uker). Hver 2-ukers periode kalles en syklus. FOLFOX inkluderer oksaliplatin, leukovorin og 5-FU. Deretter får pasienter placebo alene hver dag i totalt 3 år.	Legemiddel: 5-fluoruracil Pasienter får 400 mg/m^2 intravenøs bolus deretter 2400 mg/m^2 kontinuerlig intravenøs infusjon over 46-48 timer. Annen: placebo Pasienter får placebo administrert gjennom munnen en gang daglig. Legemiddel: oksaliplatin Pasienter får 85 mg/m^2 intravenøst over to timer. Legemiddel: leukovorin Pasienter får 400 mg/m^2 intravenøst over to timer.
Eksperimentell: Arm B - FOLFOX og celecoxib (12 behandlinger) Pasienter får FOLFOX hver 2. uke pluss celecoxib hver dag i 12 behandlinger (24 uker). Hver 2-ukers periode kalles en syklus. FOLFOX inkluderer oksaliplatin, leukovorin og 5-FU. Deretter får pasienter celecoxib alene hver dag i totalt 3 år.	Legemiddel: 5-fluoruracil Pasienter får 400 mg/m^2 intravenøs bolus deretter 2400 mg/m^2 kontinuerlig intravenøs infusjon over 46-48 timer. Legemiddel: oksaliplatin Pasienter får 85 mg/m^2 intravenøst over to timer. Legemiddel: leukovorin Pasienter får 400 mg/m^2 intravenøst over to timer. Legemiddel: celecoxib Pasienter får celecoxib 400 mg administrert gjennom munnen en gang daglig.
Aktiv komparator: Arm C - FOLFOX og placebo (6 behandlinger) Pasienter får FOLFOX hver 2. uke pluss placebo hver dag i 6 behandlinger (12 uker). Hver 2-ukers periode kalles en syklus. FOLFOX inkluderer oksaliplatin, leukovorin og 5-FU. Deretter får pasienter placebo alene hver dag i totalt 3 år.	Legemiddel: 5-fluoruracil Pasienter får 400 mg/m^2 intravenøs bolus deretter 2400 mg/m^2 kontinuerlig intravenøs infusjon over 46-48 timer. Annen: placebo Pasienter får placebo administrert gjennom munnen en gang daglig. Legemiddel: oksaliplatin Pasienter får 85 mg/m^2 intravenøst over to timer. Legemiddel: leukovorin Pasienter får 400 mg/m^2 intravenøst over to timer.
Eksperimentell: Arm D - FOLFOX og celecoxib (6 behandlinger) Pasienter får FOLFOX hver 2. uke pluss celecoxib hver dag i 6 behandlinger (12 uker). Hver 2-ukers periode kalles en syklus. FOLFOX inkluderer oksaliplatin, leukovorin og 5-FU. Deretter får pasienter celecoxib alene hver dag i totalt 3 år.	Legemiddel: 5-fluoruracil Pasienter får 400 mg/m^2 intravenøs bolus deretter 2400 mg/m^2 kontinuerlig intravenøs infusjon over 46-48 timer. Legemiddel: oksaliplatin Pasienter får 85 mg/m^2 intravenøst over to timer. Legemiddel: leukovorin Pasienter får 400 mg/m^2 intravenøst over to timer. Legemiddel: celecoxib Pasienter får celecoxib 400 mg administrert gjennom munnen en gang daglig.

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Sykdomsfri overlevelse Tidsramme: Ved 3 års oppfølging	Sykdomsfri overlevelse (DFS) er definert som tidspunktet for randomisering frem til dokumentert progresjon eller død uansett årsak. Endepunktet for denne studien er å sammenligne sykdomsfri overlevelse av pasienter med stadium III tykktarmskreft randomisert til kun standard kjemoterapi (FOLFOX; Arm A og Arm C) eller standard kjemoterapi (FOLFOX) med 3 års celecoxib 400 mg daglig (Arm B) og arm D). Her rapporteres prosentandelen av pasienter som var i live og sykdomsfrie etter 3 år. En log-rank test stratifisert med stratifiseringsfaktorene ble brukt for å sammenligne sykdomsfri overlevelse (celecoxib vs placebo)	Ved 3 års oppfølging

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Total overlevelse Tidsramme: inntil 3 år fra registrering	Total overlevelse (DFS) er definert som tidspunktet for randomisering frem til dokumentert død uansett årsak. Endepunktet er å sammenligne total overlevelse av pasienter med stadium III tykktarmskreft randomisert til kun standard kjemoterapi (FOLFOX; Arm A og Arm C) eller standard kjemoterapi (FOLFOX) med 5 års celecoxib 400 mg daglig (arm B og Arm D). Her rapporteres prosentandelen av pasienter som var i live etter 3 år.	inntil 3 år fra registrering

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbeidspartnere

National Cancer Institute (NCI)

Etterforskere

Studiestol: Jeffrey Meyerhardt, MD, MPH, Dana-Farber Cancer Institute

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Hjelpsomme linker

Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart

1. juni 2010

Primær fullføring (Faktiske)

28. februar 2020

Studiet fullført (Faktiske)

11. august 2022

Datoer for studieregistrering

Først innsendt

23. juni 2010

Først innsendt som oppfylte QC-kriteriene

23. juni 2010

Først lagt ut (Antatt)

24. juni 2010

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

19. mai 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

28. april 2026

Sist bekreftet

1. april 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

CALGB-80702
U10CA031946 (U.S. NIH-stipend/kontrakt)
CDR0000675693 (Registeridentifikator: NCI Physician Data Query)

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Oksaliplatin, Leucovorin Kalsium og Fluorouracil med eller uten Celecoxib ved behandling av pasienter med stadium III tykktarmskreft tidligere behandlet med kirurgi

En fase III-studie med 6 versus 12 behandlinger av adjuvant FOLFOX Plus Celecoxib eller placebo for pasienter med reseksjonert stadium III tykktarmskreft

Studieoversikt

Status

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Studietype

Registrering (Faktiske)

Fase

Kontakter og plasseringer

Studiesteder

Deltakelseskriterier

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Tar imot friske frivillige

Beskrivelse

Studieplan

Hvordan er studiet utformet?

Designdetaljer

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm

Intervensjon / Behandling

Hva måler studien?

Primære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Samarbeidspartnere og etterforskere

Sponsor

Samarbeidspartnere

Etterforskere

Publikasjoner og nyttige lenker

Generelle publikasjoner

Hjelpsomme linker

Studierekorddatoer

Studer hoveddatoer

Studiestart

Primær fullføring (Faktiske)

Studiet fullført (Faktiske)

Datoer for studieregistrering

Først innsendt

Først innsendt som oppfylte QC-kriteriene

Først lagt ut (Antatt)

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

Siste oppdatering sendt inn som oppfylte QC-kriteriene

Sist bekreftet

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre