- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT03768414
Gemcitabinhydroklorid og cisplatin med eller uten Nab-Paclitaxel ved behandling av pasienter med nylig diagnostisert avansert galleveiskreft
En fase III randomisert studie av gemcitabin, cisplatin og nab-paklitaxel versus gemcitabin og cisplatin i nylig diagnostisert, avansert galleveiskreft
Studieoversikt
Status
Forhold
- Stadium III intrahepatisk kolangiokarsinom AJCC v8
- Stadium IIIA intrahepatisk kolangiokarsinom AJCC v8
- Stadium IIIB intrahepatisk kolangiokarsinom AJCC v8
- Stage III galleblærenkreft AJCC v8
- Fase IIIA Galleblærekreft AJCC v8
- Stage IIIB galleblærenkreft AJCC v8
- Ikke-opererbart ekstrahepatisk gallekanalkarsinom
- Uoperabelt galleblærekarsinom
- Stage IV galleblærenkreft AJCC v8
- Stage IV intrahepatisk kolangiokarsinom AJCC v8
- Stage IV Distal gallekanalkreft AJCC v8
- Stage IVB Galleblærekreft AJCC v8
- Ikke-opererbart intrahepatisk kolangiokarsinom
- Stage III Distal gallekanalkreft AJCC v8
- Stage IIIA Distal gallekanalkreft AJCC v8
- Stage IIIB Distal gallekanalkreft AJCC v8
- Stage IVA galleblærekreft AJCC v8
Intervensjon / Behandling
Detaljert beskrivelse
PRIMÆRE MÅL:
I. For å sammenligne total overlevelse (OS) hos pasienter med ubehandlet, avansert gallekreft behandlet med gemcitabinhydroklorid (gemcitabin) og cisplatin (GC) versus de behandlet med gemcitabin, cisplatin og nab-Paclitaxel (GCN).
SEKUNDÆRE MÅL:
I. For å sammenligne progresjonsfri overlevelse (PFS) hos pasienter behandlet med GC versus GCN.
II. For å sammenligne total responsrate (ORR), fullstendig og delvis, bekreftet og ubekreftet, i undergruppen av pasienter med målbar sykdom behandlet med GC versus GCN.
III. For å sammenligne sykdomskontrollrate (bekreftet og ubekreftet; fullstendig respons + delvis respons + stabil sykdom) (DCR) hos pasienter behandlet med GC versus GCN.
IV. For å evaluere hyppigheten og alvorlighetsgraden av toksisitet assosiert med GC og GCN i pasientpopulasjonen.
V. Å utforske sammenhengen mellom endring i kreftantigen 19-9 (CA19-9) nivåer fra baseline til etterbehandling (etter 3 sykluser) og total responsrate, i hver behandlingsarm separat og i den totale kohorten.
YTTERLIGERE MÅL:
I. Å banke vev og blod for fremtidige translasjonsmedisinske studier.
OVERSIGT: Pasienter randomiseres til 1 av 2 armer.
ARM I: Pasienter får nab-paklitaksel intravenøst (IV) over 30 minutter, cisplatin IV over 60 minutter og gemcitabinhydroklorid IV over 30 minutter på dag 1 og 8. Kursene gjentas hver 21. dag i fravær av sykdomsprogresjon eller uakseptabel toksisitet.
ARM II: Pasienter får cisplatin IV over 60 minutter og gemcitabinhydroklorid IV over 30 minutter på dag 1 og 8. Kursene gjentas hver 21. dag i fravær av sykdomsprogresjon eller uakseptabel toksisitet.
Etter avsluttet studiebehandling følges pasientene opp hver 6. måned i 2 år og deretter ved slutten av år 3.
Studietype
Registrering (Faktiske)
Fase
- Fase 3
Kontakter og plasseringer
Studiesteder
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-
Alaska
-
Anchorage, Alaska, Forente stater, 98508
- Anchorage Associates in Radiation Medicine
-
Anchorage, Alaska, Forente stater, 99508
- Alaska Breast Care and Surgery LLC
-
Anchorage, Alaska, Forente stater, 99508
- Alaska Oncology and Hematology LLC
-
Anchorage, Alaska, Forente stater, 99508
- Alaska Women's Cancer Care
-
Anchorage, Alaska, Forente stater, 99508
- Anchorage Oncology Centre
-
Anchorage, Alaska, Forente stater, 99508
- Katmai Oncology Group
-
Anchorage, Alaska, Forente stater, 99508
- Providence Alaska Medical Center
-
Anchorage, Alaska, Forente stater, 99504
- Anchorage Radiation Therapy Center
-
-
Arizona
-
Goodyear, Arizona, Forente stater, 85338
- CTCA at Western Regional Medical Center
-
Kingman, Arizona, Forente stater, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Forente stater, 85054
- Mayo Clinic Hospital in Arizona
-
Phoenix, Arizona, Forente stater, 85004
- Cancer Center at Saint Joseph's
-
Scottsdale, Arizona, Forente stater, 85259
- Mayo Clinic in Arizona
-
Tucson, Arizona, Forente stater, 85704
- University of Arizona Cancer Center-Orange Grove Campus
-
Tucson, Arizona, Forente stater, 85719
- Banner University Medical Center - Tucson
-
Tucson, Arizona, Forente stater, 85719
- University of Arizona Cancer Center-North Campus
-
-
Arkansas
-
Fort Smith, Arkansas, Forente stater, 72903
- Mercy Hospital Fort Smith
-
Hot Springs, Arkansas, Forente stater, 71913
- CHI Saint Vincent Cancer Center Hot Springs
-
Jonesboro, Arkansas, Forente stater, 72401
- Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
-
Little Rock, Arkansas, Forente stater, 72205
- University of Arkansas for Medical Sciences
-
-
California
-
Arroyo Grande, California, Forente stater, 93420
- PCR Oncology
-
Arroyo Grande, California, Forente stater, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Burbank, California, Forente stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
-
Clovis, California, Forente stater, 93611
- Community Cancer Institute
-
Clovis, California, Forente stater, 93611
- University Oncology Associates
-
Corona, California, Forente stater, 92879
- City of Hope Corona
-
Duarte, California, Forente stater, 91010
- City of Hope Comprehensive Cancer Center
-
Los Angeles, California, Forente stater, 90033
- USC / Norris Comprehensive Cancer Center
-
Los Angeles, California, Forente stater, 90033
- Los Angeles County-USC Medical Center
-
Marysville, California, Forente stater, 95901
- Fremont - Rideout Cancer Center
-
Mission Hills, California, Forente stater, 91345
- City of Hope Mission Hills
-
Newport Beach, California, Forente stater, 92663
- USC Norris Oncology/Hematology-Newport Beach
-
Orange, California, Forente stater, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
-
Palo Alto, California, Forente stater, 94304
- Stanford Cancer Institute Palo Alto
-
Sacramento, California, Forente stater, 95817
- University of California Davis Comprehensive Cancer Center
-
Salinas, California, Forente stater, 93901
- Salinas Valley Memorial
-
San Francisco, California, Forente stater, 94158
- UCSF Medical Center-Mission Bay
-
San Luis Obispo, California, Forente stater, 93401
- Pacific Central Coast Health Center-San Luis Obispo
-
Santa Clarita, California, Forente stater, 91355
- City of Hope - Santa Clarita
-
Santa Maria, California, Forente stater, 93444
- Mission Hope Medical Oncology - Santa Maria
-
South Pasadena, California, Forente stater, 91030
- City of Hope South Pasadena
-
Truckee, California, Forente stater, 96161
- Gene Upshaw Memorial Tahoe Forest Cancer Center
-
Upland, California, Forente stater, 91786
- City of Hope Upland
-
West Covina, California, Forente stater, 91790
- City of Hope West Covina
-
-
Colorado
-
Aurora, Colorado, Forente stater, 80045
- Rocky Mountain Regional VA Medical Center
-
Colorado Springs, Colorado, Forente stater, 80907
- Penrose-Saint Francis Healthcare
-
Colorado Springs, Colorado, Forente stater, 80907
- Rocky Mountain Cancer Centers-Penrose
-
Denver, Colorado, Forente stater, 80210
- Porter Adventist Hospital
-
Durango, Colorado, Forente stater, 81301
- Mercy Medical Center
-
Durango, Colorado, Forente stater, 81301
- Southwest Oncology PC
-
Golden, Colorado, Forente stater, 80401
- Mountain Blue Cancer Care Center
-
Lakewood, Colorado, Forente stater, 80228
- Saint Anthony Hospital
-
Lakewood, Colorado, Forente stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
-
Littleton, Colorado, Forente stater, 80122
- Littleton Adventist Hospital
-
Longmont, Colorado, Forente stater, 80501
- Longmont United Hospital
-
Longmont, Colorado, Forente stater, 80501
- Rocky Mountain Cancer Centers-Longmont
-
Parker, Colorado, Forente stater, 80138
- Parker Adventist Hospital
-
Parker, Colorado, Forente stater, 80138
- Rocky Mountain Cancer Centers-Parker
-
Pueblo, Colorado, Forente stater, 81004
- Saint Mary Corwin Medical Center
-
Pueblo, Colorado, Forente stater, 81008
- Rocky Mountain Cancer Centers - Pueblo
-
Thornton, Colorado, Forente stater, 80260
- Rocky Mountain Cancer Centers-Thornton
-
-
Connecticut
-
Derby, Connecticut, Forente stater, 06418
- Smilow Cancer Hospital-Derby Care Center
-
Fairfield, Connecticut, Forente stater, 06824
- Smilow Cancer Hospital Care Center-Fairfield
-
Guilford, Connecticut, Forente stater, 06437
- Smilow Cancer Hospital Care Center - Guiford
-
Hartford, Connecticut, Forente stater, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
-
New Haven, Connecticut, Forente stater, 06520
- Yale University
-
New Haven, Connecticut, Forente stater, 06510
- Smilow Cancer Center/Yale-New Haven Hospital
-
North Haven, Connecticut, Forente stater, 06473
- Yale-New Haven Hospital North Haven Medical Center
-
Orange, Connecticut, Forente stater, 06477
- Smilow Cancer Hospital-Orange Care Center
-
Torrington, Connecticut, Forente stater, 06790
- Smilow Cancer Hospital-Torrington Care Center
-
Trumbull, Connecticut, Forente stater, 06611
- Smilow Cancer Hospital Care Center-Trumbull
-
Waterbury, Connecticut, Forente stater, 06708
- Smilow Cancer Hospital-Waterbury Care Center
-
Waterford, Connecticut, Forente stater, 06385
- Smilow Cancer Hospital Care Center - Waterford
-
-
Delaware
-
Frankford, Delaware, Forente stater, 19945
- Beebe South Coastal Health Campus
-
Lewes, Delaware, Forente stater, 19958
- Beebe Medical Center
-
Newark, Delaware, Forente stater, 19713
- Helen F Graham Cancer Center
-
Newark, Delaware, Forente stater, 19713
- Delaware Clinical and Laboratory Physicians PA
-
Newark, Delaware, Forente stater, 19713
- Medical Oncology Hematology Consultants PA
-
Newark, Delaware, Forente stater, 19718
- Christiana Care Health System-Christiana Hospital
-
Rehoboth Beach, Delaware, Forente stater, 19971
- Beebe Health Campus
-
Seaford, Delaware, Forente stater, 19973
- TidalHealth Nanticoke / Allen Cancer Center
-
Wilmington, Delaware, Forente stater, 19801
- Christiana Care Health System-Wilmington Hospital
-
-
District of Columbia
-
Washington, District of Columbia, Forente stater, 20016
- Sibley Memorial Hospital
-
-
Florida
-
Altamonte Springs, Florida, Forente stater, 32701
- AdventHealth Altamonte
-
Aventura, Florida, Forente stater, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
-
Celebration, Florida, Forente stater, 34747
- AdventHealth Celebration
-
Fort Myers, Florida, Forente stater, 33905
- Regional Cancer Center-Lee Memorial Health System
-
Jacksonville, Florida, Forente stater, 32224-9980
- Mayo Clinic in Florida
-
Kissimmee, Florida, Forente stater, 34744
- AdventHealth Kissimmee
-
Miami Beach, Florida, Forente stater, 33140
- Mount Sinai Medical Center
-
Orlando, Florida, Forente stater, 32803
- AdventHealth Orlando
-
Orlando, Florida, Forente stater, 32803
- AdventHealth Medical Group Urology at Orlando
-
Orlando, Florida, Forente stater, 32822
- AdventHealth East Orlando
-
Winter Park, Florida, Forente stater, 32792
- AdventHealth Winter Park
-
-
Hawaii
-
'Aiea, Hawaii, Forente stater, 96701
- Hawaii Cancer Care - Savio
-
'Aiea, Hawaii, Forente stater, 96701
- Pali Momi Medical Center
-
'Aiea, Hawaii, Forente stater, 96701
- Queen's Cancer Center - Pearlridge
-
'Aiea, Hawaii, Forente stater, 96701
- The Cancer Center of Hawaii-Pali Momi
-
Honolulu, Hawaii, Forente stater, 96813
- Queen's Medical Center
-
Honolulu, Hawaii, Forente stater, 96817
- The Cancer Center of Hawaii-Liliha
-
Honolulu, Hawaii, Forente stater, 96813
- Queen's Cancer Cenrer - POB I
-
Honolulu, Hawaii, Forente stater, 96813
- Straub Clinic and Hospital
-
Honolulu, Hawaii, Forente stater, 96813
- University of Hawaii Cancer Center
-
Honolulu, Hawaii, Forente stater, 96817
- Hawaii Cancer Care Inc-Liliha
-
Honolulu, Hawaii, Forente stater, 96817
- Kuakini Medical Center
-
Honolulu, Hawaii, Forente stater, 96817
- Queen's Cancer Center - Kuakini
-
Honolulu, Hawaii, Forente stater, 96826
- Kapiolani Medical Center for Women and Children
-
Honolulu, Hawaii, Forente stater, 96813
- Island Urology
-
Honolulu, Hawaii, Forente stater, 96813
- Hawaii Cancer Care Inc-POB II
-
Lihue, Hawaii, Forente stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
-
-
Idaho
-
Boise, Idaho, Forente stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Boise, Idaho, Forente stater, 83712
- Saint Luke's Mountain States Tumor Institute
-
Caldwell, Idaho, Forente stater, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
-
Coeur d'Alene, Idaho, Forente stater, 83814
- Kootenai Medical Center
-
Emmett, Idaho, Forente stater, 83617
- Walter Knox Memorial Hospital
-
Fruitland, Idaho, Forente stater, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, Forente stater, 83642
- Idaho Urologic Institute-Meridian
-
Meridian, Idaho, Forente stater, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, Forente stater, 83686
- Saint Alphonsus Medical Center-Nampa
-
Nampa, Idaho, Forente stater, 83686
- Saint Luke's Cancer Institute - Nampa
-
Post Falls, Idaho, Forente stater, 83854
- Kootenai Cancer Center
-
Sandpoint, Idaho, Forente stater, 83864
- Kootenai Cancer Clinic
-
Twin Falls, Idaho, Forente stater, 83301
- Saint Luke's Cancer Institute - Twin Falls
-
-
Illinois
-
Aurora, Illinois, Forente stater, 60504
- Rush - Copley Medical Center
-
Bloomington, Illinois, Forente stater, 61704
- Illinois CancerCare-Bloomington
-
Canton, Illinois, Forente stater, 61520
- Illinois CancerCare-Canton
-
Carbondale, Illinois, Forente stater, 62902
- Memorial Hospital of Carbondale
-
Carterville, Illinois, Forente stater, 62918
- SIH Cancer Institute
-
Carthage, Illinois, Forente stater, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, Forente stater, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, Forente stater, 60611
- Northwestern University
-
Chicago, Illinois, Forente stater, 60612
- University of Illinois
-
Danville, Illinois, Forente stater, 61832
- Carle on Vermilion
-
DeKalb, Illinois, Forente stater, 60115
- Northwestern Medicine Cancer Center Kishwaukee
-
Decatur, Illinois, Forente stater, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Forente stater, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Dixon, Illinois, Forente stater, 61021
- Illinois CancerCare-Dixon
-
Effingham, Illinois, Forente stater, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Forente stater, 62401
- Carle Physician Group-Effingham
-
Eureka, Illinois, Forente stater, 61530
- Illinois CancerCare-Eureka
-
Galesburg, Illinois, Forente stater, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Forente stater, 61401
- Illinois CancerCare-Galesburg
-
Geneva, Illinois, Forente stater, 60134
- Northwestern Medicine Cancer Center Delnor
-
Joliet, Illinois, Forente stater, 60435
- Joliet Oncology-Hematology Associates Limited
-
Kewanee, Illinois, Forente stater, 61443
- Illinois CancerCare-Kewanee Clinic
-
Lake Forest, Illinois, Forente stater, 60045
- Northwestern Medicine Lake Forest Hospital
-
Macomb, Illinois, Forente stater, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Forente stater, 61938
- Carle Physician Group-Mattoon/Charleston
-
Mount Vernon, Illinois, Forente stater, 62864
- Good Samaritan Regional Health Center
-
O'Fallon, Illinois, Forente stater, 62269
- Cancer Care Center of O'Fallon
-
Ottawa, Illinois, Forente stater, 61350
- Illinois CancerCare-Ottawa Clinic
-
Pekin, Illinois, Forente stater, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Forente stater, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
-
Peoria, Illinois, Forente stater, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Forente stater, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Forente stater, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Forente stater, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Forente stater, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Forente stater, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Forente stater, 61356
- Illinois CancerCare-Princeton
-
Silvis, Illinois, Forente stater, 61282
- Genesis Cancer Center - Silvis
-
Springfield, Illinois, Forente stater, 62781
- Memorial Medical Center
-
Springfield, Illinois, Forente stater, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Forente stater, 62702
- Springfield Clinic
-
Swansea, Illinois, Forente stater, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Forente stater, 61801
- Carle Cancer Center
-
Urbana, Illinois, Forente stater, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Forente stater, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Yorkville, Illinois, Forente stater, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Carmel, Indiana, Forente stater, 46032
- IU Health North Hospital
-
Indianapolis, Indiana, Forente stater, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Forente stater, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Lafayette, Indiana, Forente stater, 47905
- Franciscan Saint Elizabeth Health - Lafayette East
-
Michigan City, Indiana, Forente stater, 46360
- Woodland Cancer Care Center
-
Mooresville, Indiana, Forente stater, 46158
- Franciscan Health Mooresville
-
Richmond, Indiana, Forente stater, 47374
- Reid Health
-
Terre Haute, Indiana, Forente stater, 47804
- Union Hospital
-
-
Iowa
-
Ames, Iowa, Forente stater, 50010
- McFarland Clinic PC - Ames
-
Ames, Iowa, Forente stater, 50010
- Mary Greeley Medical Center
-
Boone, Iowa, Forente stater, 50036
- McFarland Clinic PC-Boone
-
Clive, Iowa, Forente stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forente stater, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, Forente stater, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Forente stater, 50801
- Greater Regional Medical Center
-
Davenport, Iowa, Forente stater, 52803
- Genesis Medical Center - East Campus
-
Davenport, Iowa, Forente stater, 52804
- Genesis Cancer Care Institute
-
Davenport, Iowa, Forente stater, 52807
- Iowa Cancer Specialists
-
Des Moines, Iowa, Forente stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forente stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forente stater, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, Forente stater, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Forente stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forente stater, 50314
- Medical Oncology and Hematology Associates-Laurel
-
Fort Dodge, Iowa, Forente stater, 50501
- McFarland Clinic PC-Trinity Cancer Center
-
Fort Dodge, Iowa, Forente stater, 50501
- Trinity Regional Medical Center
-
Jefferson, Iowa, Forente stater, 50129
- McFarland Clinic PC-Jefferson
-
Marshalltown, Iowa, Forente stater, 50158
- McFarland Clinic PC-Marshalltown
-
Sioux City, Iowa, Forente stater, 51101
- Siouxland Regional Cancer Center
-
West Des Moines, Iowa, Forente stater, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Forente stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Lawrence, Kansas, Forente stater, 66044
- Lawrence Memorial Hospital
-
Wichita, Kansas, Forente stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forente stater, 67214
- Cancer Center of Kansas - Wichita
-
-
Kentucky
-
Bardstown, Kentucky, Forente stater, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Forente stater, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Forente stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forente stater, 40509
- Saint Joseph Hospital East
-
London, Kentucky, Forente stater, 40741
- Saint Joseph London
-
Louisville, Kentucky, Forente stater, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Forente stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forente stater, 40215
- Saints Mary and Elizabeth Hospital
-
Louisville, Kentucky, Forente stater, 40245
- Jewish Hospital Medical Center Northeast
-
Shepherdsville, Kentucky, Forente stater, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Forente stater, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Forente stater, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Forente stater, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Forente stater, 70809
- Our Lady of the Lake Physicians Group - Medical Oncology
-
Baton Rouge, Louisiana, Forente stater, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, Forente stater, 70836
- Ochsner High Grove
-
New Orleans, Louisiana, Forente stater, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Forente stater, 70112
- Louisiana State University Health Science Center
-
-
Maine
-
Augusta, Maine, Forente stater, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Forente stater, 04401
- Eastern Maine Medical Center
-
Belfast, Maine, Forente stater, 04915
- Waldo County General Hospital
-
Biddeford, Maine, Forente stater, 04005
- MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
-
Brewer, Maine, Forente stater, 04412
- Lafayette Family Cancer Center-EMMC
-
Norway, Maine, Forente stater, 04268
- Stephens Memorial Hospital
-
Rockport, Maine, Forente stater, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Forente stater, 04073
- MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
-
South Portland, Maine, Forente stater, 04106
- Maine Medical Partners - South Portland
-
-
Maryland
-
Baltimore, Maryland, Forente stater, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
-
Massachusetts
-
Boston, Massachusetts, Forente stater, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, Forente stater, 02215
- Dana-Farber Cancer Institute
-
Lowell, Massachusetts, Forente stater, 01854
- Lowell General Hospital
-
Worcester, Massachusetts, Forente stater, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Forente stater, 48109
- University of Michigan Comprehensive Cancer Center
-
Battle Creek, Michigan, Forente stater, 49017
- Bronson Battle Creek
-
Bay City, Michigan, Forente stater, 48706
- McLaren Cancer Institute-Bay City
-
Brownstown, Michigan, Forente stater, 48183
- Henry Ford Cancer Institute-Downriver
-
Clarkston, Michigan, Forente stater, 48346
- McLaren Cancer Institute-Clarkston
-
Clinton Township, Michigan, Forente stater, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, Forente stater, 48126
- Henry Ford Medical Center-Fairlane
-
Detroit, Michigan, Forente stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forente stater, 48201
- Wayne State University/Karmanos Cancer Institute
-
Farmington Hills, Michigan, Forente stater, 48334
- Weisberg Cancer Treatment Center
-
Flint, Michigan, Forente stater, 48532
- McLaren Cancer Institute-Flint
-
Flint, Michigan, Forente stater, 48532
- Singh and Arora Hematology Oncology PC
-
Grand Rapids, Michigan, Forente stater, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, Forente stater, 49503
- Helen DeVos Children's Hospital at Spectrum Health
-
Grand Rapids, Michigan, Forente stater, 49503
- Mercy Health Saint Mary's
-
Jackson, Michigan, Forente stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forente stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forente stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forente stater, 49048
- Borgess Medical Center
-
Lansing, Michigan, Forente stater, 48910
- McLaren-Greater Lansing
-
Lansing, Michigan, Forente stater, 48912
- Mid-Michigan Physicians-Lansing
-
Lapeer, Michigan, Forente stater, 48446
- McLaren Cancer Institute-Lapeer Region
-
Mount Clemens, Michigan, Forente stater, 48043
- McLaren Cancer Institute-Macomb
-
Mount Pleasant, Michigan, Forente stater, 48858
- McLaren Cancer Institute-Central Michigan
-
Muskegon, Michigan, Forente stater, 49444
- Mercy Health Mercy Campus
-
Niles, Michigan, Forente stater, 49120
- Lakeland Hospital Niles
-
Norton Shores, Michigan, Forente stater, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi, Michigan, Forente stater, 48374
- Ascension Providence Hospitals - Novi
-
Novi, Michigan, Forente stater, 48377
- Henry Ford Medical Center-Columbus
-
Port Huron, Michigan, Forente stater, 48060
- McLaren-Port Huron
-
Port Huron, Michigan, Forente stater, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, Forente stater, 48060
- Huron Medical Center PC
-
Reed City, Michigan, Forente stater, 49677
- Spectrum Health Reed City Hospital
-
Saint Joseph, Michigan, Forente stater, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, Forente stater, 49085
- Marie Yeager Cancer Center
-
Shelby, Michigan, Forente stater, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Southfield, Michigan, Forente stater, 48075
- Ascension Providence Hospitals - Southfield
-
Traverse City, Michigan, Forente stater, 49684
- Munson Medical Center
-
West Bloomfield, Michigan, Forente stater, 48322
- Henry Ford West Bloomfield Hospital
-
Wyoming, Michigan, Forente stater, 49519
- Metro Health Hospital
-
-
Minnesota
-
Aitkin, Minnesota, Forente stater, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, Forente stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forente stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forente stater, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Forente stater, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Forente stater, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Forente stater, 55433
- Mercy Hospital
-
Deer River, Minnesota, Forente stater, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Forente stater, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Forente stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forente stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forente stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forente stater, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Forente stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Forente stater, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Forente stater, 55432
- Unity Hospital
-
Hibbing, Minnesota, Forente stater, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, Forente stater, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Forente stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forente stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forente stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forente stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forente stater, 55454
- Health Partners Inc
-
Monticello, Minnesota, Forente stater, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Forente stater, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Forente stater, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, Forente stater, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Forente stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forente stater, 55905
- Mayo Clinic in Rochester
-
Saint Louis Park, Minnesota, Forente stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forente stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forente stater, 55102
- United Hospital
-
Sandstone, Minnesota, Forente stater, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Forente stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forente stater, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Forente stater, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Forente stater, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Forente stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forente stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forente stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Forente stater, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Forente stater, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Columbus, Mississippi, Forente stater, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Corinth, Mississippi, Forente stater, 38834
- The West Clinic - Corinth
-
Grenada, Mississippi, Forente stater, 38901
- Baptist Cancer Center-Grenada
-
Gulfport, Mississippi, Forente stater, 39502
- Gulfport Memorial Hospital
-
New Albany, Mississippi, Forente stater, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Forente stater, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southaven, Mississippi, Forente stater, 38671
- The West Clinic - Southaven
-
Southhaven, Mississippi, Forente stater, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Forente stater, 63011
- Saint Louis Cancer and Breast Institute-Ballwin
-
Bonne Terre, Missouri, Forente stater, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Forente stater, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Forente stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forente stater, 63703
- Southeast Cancer Center
-
Chesterfield, Missouri, Forente stater, 63017
- Saint Luke's Hospital
-
Creve Coeur, Missouri, Forente stater, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Forente stater, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Forente stater, 65109
- Capital Region Southwest Campus
-
Joplin, Missouri, Forente stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forente stater, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, Forente stater, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, Forente stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, Forente stater, 64506
- Heartland Regional Medical Center
-
Saint Louis, Missouri, Forente stater, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, Forente stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forente stater, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, Forente stater, 63128
- Mercy Hospital South
-
Saint Louis, Missouri, Forente stater, 63129
- Siteman Cancer Center-South County
-
Saint Louis, Missouri, Forente stater, 63136
- Siteman Cancer Center at Christian Hospital
-
Saint Louis, Missouri, Forente stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Peters, Missouri, Forente stater, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Sainte Genevieve, Missouri, Forente stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forente stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forente stater, 65804
- Mercy Hospital Springfield
-
Sullivan, Missouri, Forente stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forente stater, 63127
- Missouri Baptist Outpatient Center-Sunset Hills
-
Washington, Missouri, Forente stater, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Forente stater, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Forente stater, 59101
- Billings Clinic Cancer Center
-
Bozeman, Montana, Forente stater, 59715
- Bozeman Deaconess Hospital
-
Great Falls, Montana, Forente stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forente stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Helena, Montana, Forente stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forente stater, 59901
- Kalispell Regional Medical Center
-
Missoula, Montana, Forente stater, 59804
- Community Medical Hospital
-
Missoula, Montana, Forente stater, 59802
- Saint Patrick Hospital - Community Hospital
-
-
Nebraska
-
Grand Island, Nebraska, Forente stater, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, Forente stater, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Forente stater, 68845
- Heartland Hematology and Oncology
-
Lincoln, Nebraska, Forente stater, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Forente stater, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Forente stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forente stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forente stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forente stater, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Forente stater, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Forente stater, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Forente stater, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Forente stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forente stater, 89052
- OptumCare Cancer Care at Seven Hills
-
Henderson, Nevada, Forente stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forente stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forente stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forente stater, 89074
- 21st Century Oncology-Henderson
-
Henderson, Nevada, Forente stater, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Forente stater, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Forente stater, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Forente stater, 89074
- Urology Specialists of Nevada - Green Valley
-
Las Vegas, Nevada, Forente stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forente stater, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Forente stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forente stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forente stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forente stater, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Forente stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forente stater, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Forente stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forente stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forente stater, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Forente stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forente stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forente stater, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Forente stater, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Forente stater, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Forente stater, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Forente stater, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Forente stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forente stater, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Forente stater, 89109
- 21st Century Oncology
-
Las Vegas, Nevada, Forente stater, 89128
- 21st Century Oncology-Vegas Tenaya
-
Las Vegas, Nevada, Forente stater, 89148
- 21st Century Oncology-Fort Apache
-
Las Vegas, Nevada, Forente stater, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Forente stater, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Forente stater, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Forente stater, 89102
- OptumCare Cancer Care at Oakey
-
Las Vegas, Nevada, Forente stater, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Forente stater, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Forente stater, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Forente stater, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Forente stater, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Forente stater, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Forente stater, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Forente stater, 89148
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Forente stater, 89169
- University Cancer Center
-
Pahrump, Nevada, Forente stater, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Forente stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forente stater, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Forente stater, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Lebanon, New Hampshire, Forente stater, 03756
- Dartmouth Hitchcock Medical Center
-
-
New Jersey
-
Basking Ridge, New Jersey, Forente stater, 07920
- Memorial Sloan Kettering Basking Ridge
-
Middletown, New Jersey, Forente stater, 07748
- Memorial Sloan Kettering Monmouth
-
Montvale, New Jersey, Forente stater, 07645
- Memorial Sloan Kettering Bergen
-
New Brunswick, New Jersey, Forente stater, 08903
- Rutgers Cancer Institute of New Jersey
-
Teaneck, New Jersey, Forente stater, 07666
- Holy Name Hospital
-
-
New Mexico
-
Albuquerque, New Mexico, Forente stater, 87102
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Forente stater, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque, New Mexico, Forente stater, 87109
- New Mexico Oncology Hematology Consultants
-
Albuquerque, New Mexico, Forente stater, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, Forente stater, 88011
- Memorial Medical Center - Las Cruces
-
Rio Rancho, New Mexico, Forente stater, 87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
-
New York
-
Bronx, New York, Forente stater, 10468
- James J Peters VA Medical Center
-
Buffalo, New York, Forente stater, 14263
- Roswell Park Cancer Institute
-
Commack, New York, Forente stater, 11725
- Memorial Sloan Kettering Commack
-
Glens Falls, New York, Forente stater, 12801
- Glens Falls Hospital
-
Harrison, New York, Forente stater, 10604
- Memorial Sloan Kettering Westchester
-
New York, New York, Forente stater, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, Forente stater, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, Forente stater, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Rochester, New York, Forente stater, 14642
- University of Rochester
-
Stony Brook, New York, Forente stater, 11794
- Stony Brook University Medical Center
-
Uniondale, New York, Forente stater, 11553
- Memorial Sloan Kettering Nassau
-
-
North Carolina
-
Clinton, North Carolina, Forente stater, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, Forente stater, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Forente stater, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, Forente stater, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, Forente stater, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, Forente stater, 28546
- Onslow Memorial Hospital
-
Kenansville, North Carolina, Forente stater, 28349
- Vidant Oncology-Kenansville
-
Kinston, North Carolina, Forente stater, 28501
- Vidant Oncology-Kinston
-
Richlands, North Carolina, Forente stater, 28574
- Vidant Oncology-Richlands
-
-
North Dakota
-
Bismarck, North Dakota, Forente stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forente stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forente stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forente stater, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Forente stater, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Forente stater, 58104
- Sanford Medical Center Fargo
-
Jamestown, North Dakota, Forente stater, 58401
- Essentia Health - Jamestown Clinic
-
-
Ohio
-
Beachwood, Ohio, Forente stater, 44122
- UHHS-Chagrin Highlands Medical Center
-
Beavercreek, Ohio, Forente stater, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Forente stater, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Forente stater, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, Forente stater, 44708
- Mercy Medical Center
-
Canton, Ohio, Forente stater, 44708
- Hematology and Oncology Associates Inc
-
Centerville, Ohio, Forente stater, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Forente stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chardon, Ohio, Forente stater, 44024
- Geauga Hospital
-
Chillicothe, Ohio, Forente stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forente stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forente stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forente stater, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Forente stater, 45219
- University of Cincinnati/Barrett Cancer Center
-
Cincinnati, Ohio, Forente stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forente stater, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Forente stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forente stater, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Forente stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forente stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forente stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forente stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forente stater, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Forente stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forente stater, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Forente stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forente stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forente stater, 45415
- Dayton Physician LLC-Miami Valley Hospital North
-
Dayton, Ohio, Forente stater, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Forente stater, 45428
- Dayton Veterans Affairs Medical Center
-
Delaware, Ohio, Forente stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forente stater, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Forente stater, 43016
- Dublin Methodist Hospital
-
Elyria, Ohio, Forente stater, 44035
- Mercy Cancer Center-Elyria
-
Findlay, Ohio, Forente stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forente stater, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Forente stater, 45840
- Orion Cancer Care
-
Franklin, Ohio, Forente stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Forente stater, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, Forente stater, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, Forente stater, 45331
- Wayne Hospital
-
Greenville, Ohio, Forente stater, 45331
- Dayton Physicians LLC-Wayne
-
Grove City, Ohio, Forente stater, 43123
- Mount Carmel Grove City Hospital
-
Kettering, Ohio, Forente stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forente stater, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Forente stater, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Forente stater, 43130
- Fairfield Medical Center
-
Mansfield, Ohio, Forente stater, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Forente stater, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Forente stater, 43302
- OhioHealth Marion General Hospital
-
Mayfield Heights, Ohio, Forente stater, 44124
- UH Seidman Cancer Center at Landerbrook Health Center
-
Mentor, Ohio, Forente stater, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, Forente stater, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, Forente stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forente stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forente stater, 43055
- Newark Radiation Oncology
-
Parma, Ohio, Forente stater, 44129
- University Hospitals Parma Medical Center
-
Portsmouth, Ohio, Forente stater, 45662
- Southern Ohio Medical Center
-
Ravenna, Ohio, Forente stater, 44266
- University Hospitals Portage Medical Center
-
Sandusky, Ohio, Forente stater, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, Forente stater, 45505
- Springfield Regional Medical Center
-
Springfield, Ohio, Forente stater, 45504
- Springfield Regional Cancer Center
-
Troy, Ohio, Forente stater, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Forente stater, 45373
- Dayton Physicians LLC-Upper Valley
-
Wadsworth, Ohio, Forente stater, 44281
- University Hospitals Sharon Health Center
-
Warren, Ohio, Forente stater, 44484
- Saint Joseph Warren Hospital
-
West Chester, Ohio, Forente stater, 45069
- University Pointe
-
Westerville, Ohio, Forente stater, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, Forente stater, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Westlake, Ohio, Forente stater, 44145
- UHHS-Westlake Medical Center
-
Youngstown, Ohio, Forente stater, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Forente stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forente stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forente stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forente stater, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Forente stater, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
Tulsa, Oklahoma, Forente stater, 74133
- Cancer Treatment Centers of America
-
-
Oregon
-
Baker City, Oregon, Forente stater, 97814
- Saint Alphonsus Medical Center-Baker City
-
Bend, Oregon, Forente stater, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Forente stater, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Forente stater, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Forente stater, 97420
- Bay Area Hospital
-
Corvallis, Oregon, Forente stater, 97330
- Good Samaritan Hospital
-
Gresham, Oregon, Forente stater, 97030
- Legacy Mount Hood Medical Center
-
Newberg, Oregon, Forente stater, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Forente stater, 97914
- Saint Alphonsus Medical Center-Ontario
-
Portland, Oregon, Forente stater, 97239
- Oregon Health and Science University
-
Portland, Oregon, Forente stater, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Forente stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forente stater, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, Forente stater, 97756
- Saint Charles Health System-Redmond
-
Tualatin, Oregon, Forente stater, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Chadds Ford, Pennsylvania, Forente stater, 19317
- Christiana Care Health System-Concord Health Center
-
Philadelphia, Pennsylvania, Forente stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forente stater, 19124
- Eastern Regional Medical Center
-
-
South Carolina
-
Anderson, South Carolina, Forente stater, 29621
- AnMed Health Cancer Center
-
Boiling Springs, South Carolina, Forente stater, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, Forente stater, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, Forente stater, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Forente stater, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Forente stater, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Forente stater, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, Forente stater, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Forente stater, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, Forente stater, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Forente stater, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Forente stater, 29379
- MGC Hematology Oncology-Union
-
-
South Dakota
-
Sioux Falls, South Dakota, Forente stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forente stater, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Bristol, Tennessee, Forente stater, 37620
- Wellmont Bristol Regional Medical Center
-
Chattanooga, Tennessee, Forente stater, 37404
- Memorial Hospital
-
Collierville, Tennessee, Forente stater, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Cookeville, Tennessee, Forente stater, 38501
- Cookeville Regional Medical Center
-
Franklin, Tennessee, Forente stater, 37067
- Vanderbilt-Ingram Cancer Center Cool Springs
-
Franklin, Tennessee, Forente stater, 37067
- Vanderbilt-Ingram Cancer Center at Franklin
-
Germantown, Tennessee, Forente stater, 38138
- The West Clinic - Wolf River
-
Hixson, Tennessee, Forente stater, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Kingsport, Tennessee, Forente stater, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Kingsport, Tennessee, Forente stater, 37660
- Regional Cancer Center at Indian Path Community Hospital
-
Memphis, Tennessee, Forente stater, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Memphis, Tennessee, Forente stater, 38104
- The West Clinic - Mid-Town
-
Nashville, Tennessee, Forente stater, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, Forente stater, 37204
- Vanderbilt Breast Center at One Hundred Oaks
-
Ooltewah, Tennessee, Forente stater, 37363
- Memorial GYN Plus
-
-
Texas
-
Abilene, Texas, Forente stater, 79601
- Hendrick Medical Center
-
Bryan, Texas, Forente stater, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Forente stater, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Forente stater, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth, Texas, Forente stater, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Houston, Texas, Forente stater, 77030
- M D Anderson Cancer Center
-
Houston, Texas, Forente stater, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, Forente stater, 77030
- Michael E DeBakey VA Medical Center
-
Houston, Texas, Forente stater, 77030
- Ben Taub General Hospital
-
Richardson, Texas, Forente stater, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
San Antonio, Texas, Forente stater, 78229
- University of Texas Health Science Center at San Antonio
-
-
Utah
-
Farmington, Utah, Forente stater, 84025
- Farmington Health Center
-
Salt Lake City, Utah, Forente stater, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Forente stater, 84106
- University of Utah Sugarhouse Health Center
-
-
Vermont
-
Berlin, Vermont, Forente stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forente stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forente stater, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Bristol, Virginia, Forente stater, 24201
- Wellmont Medical Associates-Bristol
-
Norton, Virginia, Forente stater, 24273
- Southwest VA Regional Cancer Center
-
Richmond, Virginia, Forente stater, 23235
- VCU Massey Cancer Center at Stony Point
-
Richmond, Virginia, Forente stater, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
-
Washington
-
Aberdeen, Washington, Forente stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Bellevue, Washington, Forente stater, 98004
- Overlake Medical Center
-
Bellingham, Washington, Forente stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, Forente stater, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Bremerton, Washington, Forente stater, 98310
- Harrison Medical Center
-
Burien, Washington, Forente stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forente stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forente stater, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Forente stater, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Forente stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forente stater, 98003
- Saint Francis Hospital
-
Issaquah, Washington, Forente stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forente stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Forente stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forente stater, 98499
- Saint Clare Hospital
-
Longview, Washington, Forente stater, 98632
- PeaceHealth Saint John Medical Center
-
Poulsbo, Washington, Forente stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Renton, Washington, Forente stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forente stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forente stater, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Forente stater, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Forente stater, 98122-4307
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forente stater, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, Forente stater, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Forente stater, 98584
- Providence Regional Cancer System-Shelton
-
Tacoma, Washington, Forente stater, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Forente stater, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Forente stater, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, Forente stater, 98664
- PeaceHealth Southwest Medical Center
-
Vancouver, Washington, Forente stater, 98684
- Legacy Cancer Institute Medical Oncology and Day Treatment
-
Walla Walla, Washington, Forente stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yelm, Washington, Forente stater, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Bridgeport, West Virginia, Forente stater, 26330
- United Hospital Center
-
Martinsburg, West Virginia, Forente stater, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, Forente stater, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, Forente stater, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Ashland, Wisconsin, Forente stater, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Forente stater, 54806
- Northwest Wisconsin Cancer Center
-
Burlington, Wisconsin, Forente stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Forente stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forente stater, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Forente stater, 54701
- Mayo Clinic Health System-Eau Claire Clinic
-
Fond Du Lac, Wisconsin, Forente stater, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Forente stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forente stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forente stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forente stater, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Forente stater, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Forente stater, 54301
- Bellin Memorial Hospital
-
Kenosha, Wisconsin, Forente stater, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Forente stater, 54601
- Gundersen Lutheran Medical Center
-
La Crosse, Wisconsin, Forente stater, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
Ladysmith, Wisconsin, Forente stater, 54848
- Marshfield Clinic - Ladysmith Center
-
Madison, Wisconsin, Forente stater, 53792
- University of Wisconsin Hospital and Clinics
-
Marinette, Wisconsin, Forente stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Forente stater, 54449
- Marshfield Medical Center-Marshfield
-
Milwaukee, Wisconsin, Forente stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forente stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forente stater, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Forente stater, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, Forente stater, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Forente stater, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Forente stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Forente stater, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Forente stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forente stater, 53406
- Aurora Cancer Care-Racine
-
Rice Lake, Wisconsin, Forente stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forente stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Forente stater, 54482
- Marshfield Clinic Stevens Point Center
-
Sturgeon Bay, Wisconsin, Forente stater, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Forente stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forente stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Forente stater, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Forente stater, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Forente stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forente stater, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Forente stater, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Forente stater, 54476
- Marshfield Clinic - Weston Center
-
Wisconsin Rapids, Wisconsin, Forente stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cody, Wyoming, Forente stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forente stater, 82801
- Welch Cancer Center
-
-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Beskrivelse
Inklusjonskriterier:
Pasienter må ha histologisk eller cytologisk bekreftet intrahepatisk kolangiokarsinom, ekstrahepatisk kolangiokarsinom eller galleblærekreft
- MERK: Patologirapport må lastes opp i Rave. Histologirapporten må stemme overens med et adenokarsinom med bukspyttkjertel-biliær primær, forutsatt at det ikke er noen bukspyttkjertellesjoner og andre primære er utelukket i henhold til lokal standard
- Pasienter må ha dokumentert metastatisk eller lokalt avansert ikke-opererbar sykdom på computertomografi (CT) eller magnetisk resonans (MR) CT-skanning eller MR som brukes til å vurdere målbar sykdom. Må være fullført innen 28 dager før registrering. CT-skanninger eller MR-er som brukes til å vurdere ikke-målbar sykdom, må være fullført innen 42 dager før registrering. All sykdom må vurderes og dokumenteres på Baseline Tumor Assessment Form
- Pasienten skal ikke ha en aktuell diagnose av ampullær kreft
- Pasienter må ikke ha mottatt systemisk behandling for gjeldende metastaserende eller lokalt avansert gallekreft
- Pasienten må ikke ha mottatt adjuvant behandling innen 6 måneder før registrering
- Pasienter må ha en fullstendig sykehistorie og fysisk undersøkelse innen 28 dager før registrering
- Pasienter må ha en Zubrod-ytelsesstatus på 0 eller 1
- Pasienter må ikke ha en historie med perifer nevropati av grad 2 eller høyere i henhold til Common Terminology Criteria for Adverse Events (CTCAE) 5.0. I CTCAE versjon 5.0 er grad 2 sensorisk nevropati definert som? moderate symptomer; begrense instrumentelle aktiviteter i dagliglivet (ADL)?
- Absolutt nøytrofiltall (ANC) >= 1500/mcL (oppnådd innen 28 dager før registrering)
- Blodplater >= 100 000/mcL (oppnådd innen 28 dager før registrering)
- Hemoglobin >= 8 g/dL (oppnådd innen 28 dager før registrering)
- Serumalbumin >= 2,8 g/dL (oppnådd innen 28 dager før registrering)
- Total bilirubin =< 1,5 x institusjonell øvre normalgrense (IULN) (unntatt pasienter med Gilberts syndrom, som må ha direkte bilirubin < 1,5 mg/dL) (oppnådd innen 28 dager før registrering)
- Serumglutamin-oksaloeddiksyretransaminase (SGOT) (aspartataminotransferase [AST]) og serumglutamatpyruvattransaminase (SGPT) (alaninaminotransferase [ALT]) =< 8 x IULN (oppnådd innen 28 dager før registrering)
- Serumkreatinin =< IULN ELLER beregnet kreatininclearance >= 60 ml/min (oppnådd innen 28 dager før registrering)
- Pasienter må ha CA19-9 oppnådd innen 42 dager før registrering
- Pasienter må ha natrium, kalium, bikarbonat, klorid, blod urea nitrogen (BUN), kalsium, totalt protein, magnesium og alkalisk fosfatase oppnådd innen 28 dager før registrering
- Pasienter må ikke ha en aktiv infeksjon som krever systemisk behandling
- Ingen annen tidligere malignitet er tillatt med unntak av følgende: tilstrekkelig behandlet basalcelle- eller plateepitelkreft, in situ livmorhalskreft, adekvat behandlet stadium I eller II kreft som pasienten for øyeblikket er i fullstendig remisjon fra, eller annen kreft som Pasienten har vært sykdomsfri i to år
- Pasienter må ikke være gravide eller ammende. Kvinner/menn med reproduksjonspotensial må ha samtykket til å bruke en effektiv prevensjonsmetode. En kvinne anses å ha "reproduktivt potensial" hvis hun har hatt mens på noe tidspunkt i løpet av de foregående 12 påfølgende månedene. I tillegg til rutineprevensjonsmetoder inkluderer "effektiv prevensjon" også heteroseksuelt sølibat og kirurgi ment å forhindre graviditet (eller med en bivirkning av graviditetsforebygging) definert som hysterektomi, bilateral ooforektomi eller bilateral tubal ligering. Men hvis en tidligere sølibatpasient på noe tidspunkt velger å bli heteroseksuelt aktiv i løpet av tidsperioden for bruk av prevensjonstiltak som er skissert i protokollen, er han/hun ansvarlig for å starte prevensjonstiltak
- Nettstedene må søke ytterligere pasientsamtykke for fremtidig bruk av prøver
- Pasienter må informeres om undersøkelseskarakteren til denne studien og må signere og gi skriftlig informert samtykke i samsvar med institusjonelle og føderale retningslinjer
- Som en del av registreringsprosessen for Oncology Patient Enrollment Network (OPEN) oppgis den behandlende institusjonens identitet for å sikre at den gjeldende (innen 365 dager) datoen for godkjenning av institusjonsvurderingskomiteen for denne studien er lagt inn i systemet
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
---|---|
Eksperimentell: Arm I (nab-paklitaksel, cisplatin, gemcitabinhydroklorid)
Pasienter får nab-paklitaksel IV over 30 minutter, cisplatin IV over 60 minutter og gemcitabinhydroklorid IV over 30 minutter på dag 1 og 8. Kursene gjentas hver 21. dag i fravær av sykdomsprogresjon eller uakseptabel toksisitet.
|
Gitt IV
Andre navn:
Gitt IV
Andre navn:
Gitt IV
Andre navn:
|
Eksperimentell: Arm II (cisplatin, gemcitabinhydroklorid)
Pasienter får cisplatin IV over 60 minutter og gemcitabinhydroklorid IV over 30 minutter på dag 1 og 8. Kurs gjentas hver 21. dag i fravær av sykdomsprogresjon eller uakseptabel toksisitet.
|
Gitt IV
Andre navn:
Gitt IV
Andre navn:
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
---|---|---|
Total overlevelse (OS)
Tidsramme: Inntil 3 år
|
OS vil bli bestemt ved å bruke log-rank test med stratifisering etter sykdomssted (galleblæren adenokarsinom versus [vs.] intrahepatisk kolangiokarsinom vs. ekstrahepatisk kolangiokarsinom), sykdomsstadium (lokalt avansert vs. metastatisk) og Zubrod ytelsesstatus (0 vs. 1 ).
Fordelinger av total overlevelse etter behandlingsarm vil bli estimert ved bruk av metoden til Kaplan-Meier.
|
Inntil 3 år
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
---|---|---|
Forekomst av uønskede hendelser gradert i henhold til Common Terminology Criteria for Adverse Events (CTCAE) versjon 5.0
Tidsramme: Inntil 3 år
|
Forekomster av alvorlig toksisitet vil bli sammenlignet mellom armene.
|
Inntil 3 år
|
Progresjonsfri overlevelse (PFS)
Tidsramme: Fra registreringsdato til dato for første dokumentasjon av progresjon eller symptomatisk forverring, eller død på grunn av en hvilken som helst årsak, vurdert opp til 3 år
|
Fordelinger av PFS vil bli beskrevet ved bruk av kumulative insidensestimater med forskjeller i disse estimatene mellom behandlingsarmer vurdert av en stratifisert Cox-regresjonsmodell.
|
Fra registreringsdato til dato for første dokumentasjon av progresjon eller symptomatisk forverring, eller død på grunn av en hvilken som helst årsak, vurdert opp til 3 år
|
Total responsrate (ORR) målt ved responsevalueringskriterier i solide svulster (RECIST) 1.1 kriterier
Tidsramme: Inntil 3 år
|
ORR er definert som bekreftet og ubekreftet; fullstendig respons + delvis respons + stabil sykdom.
Chi-kvadrat-testen vil bli brukt til å sammenligne ORR, sykdomskontrollrate (DCR) og rater av toksisitetshendelser på tvers av armer.
ORR vil bli vurdert i undergruppen av pasienter med målbar sykdom.
|
Inntil 3 år
|
Sykdomskontrollrate målt ved RECIST 1.1-kriterier
Tidsramme: Inntil 3 år
|
Kjikvadrattesten vil bli brukt til å sammenligne ORR, DCR og rater av toksisitetshendelser på tvers av armer.
Sykdomskontroll inkluderer bekreftet og ubekreftet fullstendig respons, bekreftet og ubekreftet delvis respons og stabil sykdom.
Hos pasienter med ikke-målbar sykdom vil sykdomskontroll defineres som de som er i live uten sykdomsprogresjon.
|
Inntil 3 år
|
Endringer i nivåer av karbohydratantigen 19-9 (CA 19-9).
Tidsramme: Baseline frem til kurs 3
|
Korrelasjoner mellom endringer i CA19-9 nivåer fra baseline til etterbehandling og ORR vil bli estimert via logistiske regresjonsmodeller, både innenfor hver behandlingsarm og i den totale kohorten.
Analyser vil utforske de prognostiske og prediktive verdiene til CA19-9 for sykdomsrespons.
|
Baseline frem til kurs 3
|
Samarbeidspartnere og etterforskere
Sponsor
Samarbeidspartnere
Etterforskere
- Hovedetterforsker: Rachna Shroff, SWOG Cancer Research Network
Studierekorddatoer
Studer hoveddatoer
Studiestart (Faktiske)
Primær fullføring (Faktiske)
Studiet fullført (Antatt)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Antatt)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
- Sykdommer i fordøyelsessystemet
- Neoplasmer etter histologisk type
- Neoplasmer
- Neoplasmer etter nettsted
- Adenokarsinom
- Neoplasmer, kjertel og epitel
- Neoplasmer i fordøyelsessystemet
- Galleblæren sykdommer
- Galleveissykdommer
- Galleveissykdommer
- Karsinom
- Kolangiokarsinom
- Neoplasmer i galleveiene
- Neoplasmer i galleblæren
- Gallekanalsneoplasmer
- Molekylære mekanismer for farmakologisk virkning
- Antimetabolitter, antineoplastisk
- Antimetabolitter
- Antineoplastiske midler
- Tubulin modulatorer
- Antimitotiske midler
- Mitosemodulatorer
- Antineoplastiske midler, fytogene
- Paklitaksel
- Cisplatin
- Albuminbundet paklitaksel
- Gemcitabin
Andre studie-ID-numre
- S1815 (Annen identifikator: CTEP)
- U10CA180888 (U.S. NIH-stipend/kontrakt)
- NCI-2018-01920 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Studerer et amerikansk FDA-regulert enhetsprodukt
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Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .
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Fred Hutchinson Cancer CenterGlaxoSmithKlineFullførtAnatomisk stadium IIB brystkreft AJCC v8 | Anatomisk stadium III brystkreft AJCC v8 | Anatomisk stadium IIIA brystkreft AJCC v8 | Anatomisk stadium IIIB brystkreft AJCC v8 | Anatomisk stadium IIIC brystkreft AJCC v8 | Prognostisk stadium IIB brystkreft AJCC v8 | Prognostisk stadium III brystkreft... og andre forholdUganda
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Ohio State University Comprehensive Cancer CenterNational Cancer Institute (NCI)Aktiv, ikke rekrutterendeAnatomisk stadium II brystkreft AJCC v8 | Anatomisk stadium IIA brystkreft AJCC v8 | Anatomisk stadium IIB brystkreft AJCC v8 | Anatomisk stadium III brystkreft AJCC v8 | Anatomisk stadium IIIA brystkreft AJCC v8 | Anatomisk stadium IIIB brystkreft AJCC v8 | Anatomisk stadium IIIC brystkreft AJCC v8 | Prognostisk stadium II brystkreft AJCC... og andre forholdForente stater
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Fred Hutchinson Cancer CenterNational Cancer Institute (NCI)FullførtStillesittende livsstil | Anatomisk stadium II brystkreft AJCC v8 | Anatomisk stadium IIA brystkreft AJCC v8 | Anatomisk stadium IIB brystkreft AJCC v8 | Anatomisk stadium III brystkreft AJCC v8 | Anatomisk stadium IIIA brystkreft AJCC v8 | Anatomisk stadium IIIB brystkreft AJCC v8 | Anatomisk stadium... og andre forholdForente stater
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Sun Yat-sen UniversityFirst Affiliated Hospital, Sun Yat-Sen University; Guangdong Provincial... og andre samarbeidspartnereAktiv, ikke rekrutterendeNasofaryngealt karsinom | Nasofaryngeale neoplasmer | Nasofaryngeale sykdommer | Neoplasma i hode og nakkeKina
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University of VermontJohnson & JohnsonRekruttering