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Immunterapi (Nivolumab eller Brentuximab Vedotin) Pluss kombinasjonskjemoterapi ved behandling av pasienter med nylig diagnostisert stadium III-IV klassisk Hodgkin-lymfom

21. oktober 2026 oppdatert av: National Cancer Institute (NCI)

A Phase III, Randomized Study of Nivolumab (Opdivo) Plus AVD or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma

This phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Brentuximab vedotin is a monoclonal antibody, brentuximab, linked to a toxic agent called vedotin. Brentuximab attaches to cancer cells in a targeted way and delivers vedotin to kill them. Chemotherapy drugs, such as doxorubicin, vinblastine, and dacarbazine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The addition of nivolumab or brentuximab vedotin to combination chemotherapy may shrink the cancer or extend the time without disease symptoms coming back.

Studieoversikt

Status

Aktiv, ikke rekrutterende

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

PRIMARY OBJECTIVE:

I. To compare the progression-free survival (PFS) in patients with newly diagnosed advanced stage classical Hodgkin lymphoma randomized to N-AVD (nivolumab, doxorubicin hydrochloride [doxorubicin], vinblastine sulfate [vinblastine], dacarbazine) versus that obtained with BV-AVD (brentuximab vedotin, doxorubicin, vinblastine, dacarbazine).

SECONDARY OBJECTIVES:

I. To compare overall survival (OS) in patients randomized to N-AVD versus BV-AVD.

II. To compare event-free survival (EFS) in patients randomized to N-AVD versus BV-AVD.

III. To compare the metabolic complete response (CR) rate at the end of treatment in patients randomized to N-AVD versus BV-AVD.

IV. To compare the physician-reported treatment-related adverse event rates between arms stratified by age groups.

V. To compare patient-reported symptoms using selected Patient Reported Outcome Common Toxicity Criteria for Adverse Events (PRO-CTCAE) items between arms stratified by age groups.

VI. To compare the safety and tolerability of N-AVD versus that of BV-AVD.

QUALITY OF LIFE OBJECTIVE:

I. To compare between arms patient-reported fatigue, neuropathy and health-related quality of life over time (baseline, beginning of cycle 3, 4-8 weeks after the last dose of protocol therapy [following last dose of study drug or radiation therapy, whichever is later], and 1 and 3 years after randomization) using the Patient Reported Outcomes Measurement Information System (PROMIS)-Fatigue, the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), and the PROMIS Global, respectively.

BANKING OBJECTIVES:

I. To bank specimens for future correlative studies. II. To bank positron emission tomography (PET)-computed tomography (CT) images for future correlative studies.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive doxorubicin hydrochloride intravenously (IV), vinblastine sulfate IV, dacarbazine IV, and nivolumab IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim subcutaneously (SC) on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician. Patients also undergo peripheral blood specimen collection and CT, PET/CT and/or magnetic resonance imaging (MRI) on study.

ARM II: Patients receive doxorubicin hydrochloride IV, vinblastine sulfate IV, dacarbazine IV, and brentuximab vedotin IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim SC on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician. Patients also undergo peripheral blood specimen collection and CT, PET/CT and MRI on study.

After completion of study treatment and prior to disease progression, patients are followed up every 3 months for the first year, every 6 months for years 2 and 3, then annually until 10 years after registration. Patients are followed up at the time of progression and then annually until 10 years after registration. Patients who receive radiation therapy are followed up at 8-12 weeks after completion of radiation therapy.

Studietype

Intervensjonell

Registrering (Faktiske)

994

Fase

  • Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Canada
      • Québec, Canada, G1V 4G2
        • CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
    • British Columbia
      • Vancouver, British Columbia, Canada, V5Z 4E6
        • BCCA-Vancouver Cancer Centre
      • Victoria, British Columbia, Canada, V8R 6V5
        • BCCA-Vancouver Island Cancer Centre
    • New Brunswick
      • Saint John, New Brunswick, Canada, E2L 4L2
        • Atlantic Health Sciences Corporation-Saint John Regional Hospital
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 2Y9
        • QEII Health Sciences Centre/Nova Scotia Health Authority
    • Ontario
      • Brampton, Ontario, Canada, L6R 3J7
        • William Osler Health System-Brampton Civic Hospital
      • Kingston, Ontario, Canada, K7L 2V7
        • Kingston Health Sciences Centre
      • Ottawa, Ontario, Canada, K1H 8L6
        • Ottawa Hospital and Cancer Center-General Campus
      • Toronto, Ontario, Canada, M5G 2M9
        • University Health Network-Princess Margaret Hospital
      • Toronto, Ontario, Canada, M5G 1X8
        • Hospital for Sick Children
    • Quebec
      • Montreal, Quebec, Canada, H3H 1P3
        • The Montreal Children's Hospital of the MUHC
      • Montreal, Quebec, Canada, H3H 2R9
        • The Research Institute of the McGill University Health Centre (MUHC)
      • Montreal, Quebec, Canada, H3T 1C5
        • Centre Hospitalier Universitaire Sainte-Justine
      • Québec, Quebec, Canada, G1J 1Z4
        • CHA Hopital L'Enfant-Jesus
    • Saskatchewan
      • Regina, Saskatchewan, Canada, S4T 7T1
        • Allan Blair Cancer Centre
  • Forente stater
    • Alabama
      • Birmingham, Alabama, Forente stater, 35233
        • University of Alabama at Birmingham Cancer Center
      • Birmingham, Alabama, Forente stater, 35233
        • Children's Hospital of Alabama
      • Mobile, Alabama, Forente stater, 36604
        • USA Health Strada Patient Care Center
      • Mobile, Alabama, Forente stater, 36688
        • University of South Alabama Mitchell Cancer Institute
    • Alaska
      • Anchorage, Alaska, Forente stater, 98508
        • Anchorage Associates in Radiation Medicine
      • Anchorage, Alaska, Forente stater, 99508
        • Alaska Breast Care and Surgery LLC
      • Anchorage, Alaska, Forente stater, 99508
        • Alaska Oncology and Hematology LLC
      • Anchorage, Alaska, Forente stater, 99508
        • Alaska Women's Cancer Care
      • Anchorage, Alaska, Forente stater, 99508
        • Anchorage Oncology Centre
      • Anchorage, Alaska, Forente stater, 99508
        • Katmai Oncology Group
      • Anchorage, Alaska, Forente stater, 99508
        • Providence Alaska Medical Center
      • Fairbanks, Alaska, Forente stater, 99701
        • Fairbanks Memorial Hospital
    • Arizona
      • Goodyear, Arizona, Forente stater, 85338
        • CTCA at Western Regional Medical Center
      • Phoenix, Arizona, Forente stater, 85004
        • Cancer Center at Saint Joseph's
      • Phoenix, Arizona, Forente stater, 85016
        • Phoenix Childrens Hospital
      • Tucson, Arizona, Forente stater, 85704
        • University of Arizona Cancer Center-Orange Grove Campus
      • Tucson, Arizona, Forente stater, 85719
        • Banner University Medical Center - Tucson
      • Tucson, Arizona, Forente stater, 85719
        • University of Arizona Cancer Center-North Campus
    • Arkansas
      • Fort Smith, Arkansas, Forente stater, 72903
        • Mercy Hospital Fort Smith
      • Hot Springs, Arkansas, Forente stater, 71913
        • CHI Saint Vincent Cancer Center Hot Springs
      • Jonesboro, Arkansas, Forente stater, 72401
        • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
      • Little Rock, Arkansas, Forente stater, 72205
        • University of Arkansas for Medical Sciences
      • Little Rock, Arkansas, Forente stater, 72202-3591
        • Arkansas Children's Hospital
    • California
      • Anaheim, California, Forente stater, 92806
        • Kaiser Permanente-Anaheim
      • Antioch, California, Forente stater, 94531
        • Kaiser Permanente-Deer Valley Medical Center
      • Arroyo Grande, California, Forente stater, 93420
        • PCR Oncology
      • Baldwin Park, California, Forente stater, 91706
        • Kaiser Permanente-Baldwin Park
      • Bellflower, California, Forente stater, 90706
        • Kaiser Permanente-Bellflower
      • Beverly Hills, California, Forente stater, 90211
        • Tower Cancer Research Foundation
      • Burbank, California, Forente stater, 91505
        • Providence Saint Joseph Medical Center/Disney Family Cancer Center
      • Duarte, California, Forente stater, 91010
        • City of Hope Comprehensive Cancer Center
      • Dublin, California, Forente stater, 94568
        • Kaiser Permanente Dublin
      • Fontana, California, Forente stater, 92335
        • Kaiser Permanente-Fontana
      • Fremont, California, Forente stater, 94538
        • Kaiser Permanente-Fremont
      • Fresno, California, Forente stater, 93720
        • Kaiser Permanente-Fresno
      • Harbor City, California, Forente stater, 90710
        • Kaiser Permanente South Bay
      • Irvine, California, Forente stater, 92618
        • Kaiser Permanente-Irvine
      • La Jolla, California, Forente stater, 92093
        • UC San Diego Moores Cancer Center
      • Loma Linda, California, Forente stater, 92354
        • Loma Linda University Medical Center
      • Los Angeles, California, Forente stater, 90048
        • Cedars-Sinai Medical Center
      • Los Angeles, California, Forente stater, 90027
        • Children's Hospital Los Angeles
      • Los Angeles, California, Forente stater, 90027
        • Kaiser Permanente Los Angeles Medical Center
      • Los Angeles, California, Forente stater, 90034
        • Kaiser Permanente West Los Angeles
      • Madera, California, Forente stater, 93636
        • Valley Children's Hospital
      • Marysville, California, Forente stater, 95901
        • Fremont - Rideout Cancer Center
      • Modesto, California, Forente stater, 95356
        • Kaiser Permanente-Modesto
      • Oakland, California, Forente stater, 94611
        • Kaiser Permanente-Oakland
      • Ontario, California, Forente stater, 91761
        • Kaiser Permanente-Ontario
      • Orange, California, Forente stater, 92868
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
      • Orange, California, Forente stater, 92868
        • Children's Hospital of Orange County
      • Palm Springs, California, Forente stater, 92262
        • Desert Regional Medical Center
      • Palo Alto, California, Forente stater, 94304
        • Stanford Cancer Institute Palo Alto
      • Panorama City, California, Forente stater, 91402
        • Kaiser Permanente - Panorama City
      • Richmond, California, Forente stater, 94801
        • Kaiser Permanente-Richmond
      • Riverside, California, Forente stater, 92505
        • Kaiser Permanente-Riverside
      • Sacramento, California, Forente stater, 95816
        • Sutter Medical Center Sacramento
      • Sacramento, California, Forente stater, 95817
        • University of California Davis Comprehensive Cancer Center
      • Sacramento, California, Forente stater, 95814
        • Kaiser Permanente Downtown Commons
      • Sacramento, California, Forente stater, 95823
        • Kaiser Permanente-South Sacramento
      • San Diego, California, Forente stater, 92123
        • Rady Children's Hospital - San Diego
      • San Diego, California, Forente stater, 92120
        • Kaiser Permanente-San Diego Zion
      • San Diego, California, Forente stater, 92134
        • Naval Medical Center -San Diego
      • San Francisco, California, Forente stater, 94115
        • Kaiser Permanente-San Francisco
      • San Francisco, California, Forente stater, 94158
        • UCSF Medical Center-Mission Bay
      • San Jose, California, Forente stater, 95119
        • Kaiser Permanente-Santa Teresa-San Jose
      • San Leandro, California, Forente stater, 94577
        • Kaiser Permanente San Leandro
      • San Luis Obispo, California, Forente stater, 93401
        • Pacific Central Coast Health Center-San Luis Obispo
      • San Marcos, California, Forente stater, 92078
        • Kaiser Permanente-San Marcos
      • San Rafael, California, Forente stater, 94903
        • Kaiser San Rafael-Gallinas
      • Santa Maria, California, Forente stater, 93444
        • Mission Hope Medical Oncology - Santa Maria
      • Santa Rosa, California, Forente stater, 95403
        • Kaiser Permanente-Santa Rosa
      • South San Francisco, California, Forente stater, 94080
        • Kaiser Permanente-South San Francisco
      • Stockton, California, Forente stater, 95210
        • Kaiser Permanente-Stockton
      • Torrance, California, Forente stater, 90502
        • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
      • Vacaville, California, Forente stater, 95688
        • Kaiser Permanente Medical Center-Vacaville
      • Vallejo, California, Forente stater, 94589
        • Kaiser Permanente-Vallejo
      • Walnut Creek, California, Forente stater, 94596
        • Kaiser Permanente-Walnut Creek
      • Whittier, California, Forente stater, 90602
        • Presbyterian Intercommunity Hospital
      • Woodland Hills, California, Forente stater, 91367
        • Kaiser Permanente-Woodland Hills
    • Colorado
      • Aurora, Colorado, Forente stater, 80045
        • Children's Hospital Colorado
      • Aurora, Colorado, Forente stater, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Aurora, Colorado, Forente stater, 80012
        • The Medical Center of Aurora
      • Aurora, Colorado, Forente stater, 80045
        • UCHealth University of Colorado Hospital
      • Boulder, Colorado, Forente stater, 80303
        • Boulder Community Foothills Hospital
      • Boulder, Colorado, Forente stater, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Colorado Springs, Colorado, Forente stater, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Forente stater, 80907
        • Rocky Mountain Cancer Centers-Penrose
      • Denver, Colorado, Forente stater, 80205
        • Kaiser Permanente-Franklin
      • Denver, Colorado, Forente stater, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forente stater, 80218
        • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
      • Denver, Colorado, Forente stater, 80218
        • Saint Joseph Hospital - Cancer Centers of Colorado
      • Denver, Colorado, Forente stater, 80210
        • AdventHealth Porter
      • Englewood, Colorado, Forente stater, 80113
        • Mountain Blue Cancer Care Center - Swedish
      • Englewood, Colorado, Forente stater, 80113
        • Swedish Medical Center
      • Grand Junction, Colorado, Forente stater, 81501
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, Forente stater, 80631
        • Banner North Colorado Medical Center
      • Lafayette, Colorado, Forente stater, 80026
        • Kaiser Permanente-Rock Creek
      • Lakewood, Colorado, Forente stater, 80228
        • CommonSpirit Saint Anthony Hospital Cancer Center
      • Littleton, Colorado, Forente stater, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Littleton, Colorado, Forente stater, 80122
        • AdventHealth Littleton
      • Lone Tree, Colorado, Forente stater, 80124
        • Kaiser Permanente-Lone Tree
      • Lone Tree, Colorado, Forente stater, 80124
        • Sky Ridge Medical Center
      • Longmont, Colorado, Forente stater, 80501
        • Longmont United Hospital
      • Loveland, Colorado, Forente stater, 80539
        • Banner North Colorado Medical Center - Loveland Campus
      • Parker, Colorado, Forente stater, 80138
        • AdventHealth Parker
      • Pueblo, Colorado, Forente stater, 81004
        • Saint Mary Corwin Medical Center
      • Thornton, Colorado, Forente stater, 80260
        • Rocky Mountain Cancer Centers-Thornton
      • Wheat Ridge, Colorado, Forente stater, 80401
        • Intermountain Health Lutheran Hospital
    • Connecticut
      • Derby, Connecticut, Forente stater, 06418
        • Smilow Cancer Hospital-Derby Care Center
      • Hartford, Connecticut, Forente stater, 06106
        • Connecticut Children's Medical Center
      • New Haven, Connecticut, Forente stater, 06520
        • Yale University
      • New Haven, Connecticut, Forente stater, 06510
        • Smilow Cancer Center/Yale-New Haven Hospital
      • Orange, Connecticut, Forente stater, 06477
        • Smilow Cancer Hospital-Orange Care Center
      • Trumbull, Connecticut, Forente stater, 06611
        • Smilow Cancer Hospital Care Center-Trumbull
      • Waterford, Connecticut, Forente stater, 06385
        • Smilow Cancer Hospital Care Center - Waterford
    • Delaware
      • Lewes, Delaware, Forente stater, 19958
        • Beebe Medical Center
      • Millville, Delaware, Forente stater, 19967
        • Beebe South Coastal Health Campus
      • Newark, Delaware, Forente stater, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, Forente stater, 19713
        • Delaware Clinical and Laboratory Physicians PA
      • Newark, Delaware, Forente stater, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Forente stater, 19718
        • Christiana Care Health System-Christiana Hospital
      • Rehoboth Beach, Delaware, Forente stater, 19971
        • Beebe Health Campus
      • Seaford, Delaware, Forente stater, 19973
        • TidalHealth Nanticoke / Allen Cancer Center
      • Wilmington, Delaware, Forente stater, 19803
        • Alfred I duPont Hospital for Children
    • District of Columbia
      • Washington D.C., District of Columbia, Forente stater, 20010
        • Children's National Medical Center
      • Washington D.C., District of Columbia, Forente stater, 20007
        • MedStar Georgetown University Hospital
    • Florida
      • Coral Gables, Florida, Forente stater, 33146
        • UM Sylvester Comprehensive Cancer Center at Coral Gables
      • Fort Lauderdale, Florida, Forente stater, 33316
        • Broward Health Medical Center
      • Fort Myers, Florida, Forente stater, 33905
        • Regional Cancer Center-Lee Memorial Health System
      • Fort Myers, Florida, Forente stater, 33908
        • Golisano Children's Hospital of Southwest Florida
      • Gainesville, Florida, Forente stater, 32610
        • UF Health Cancer Institute - Gainesville
      • Hollywood, Florida, Forente stater, 33021
        • Memorial Regional Hospital/Joe DiMaggio Children's Hospital
      • Hollywood, Florida, Forente stater, 33021
        • UM Sylvester Comprehensive Cancer Center at Hollywood
      • Jacksonville, Florida, Forente stater, 32207
        • Nemours Children's Clinic-Jacksonville
      • Loxahatchee Groves, Florida, Forente stater, 33470
        • Palms West Radiation Therapy
      • Miami, Florida, Forente stater, 33155
        • Nicklaus Children's Hospital
      • Miami, Florida, Forente stater, 33136
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
      • Miami, Florida, Forente stater, 33176
        • Miami Cancer Institute
      • Miami Beach, Florida, Forente stater, 33140
        • Mount Sinai Medical Center
      • Orlando, Florida, Forente stater, 32806
        • Orlando Health Cancer Institute
      • Orlando, Florida, Forente stater, 32827
        • Nemours Children's Hospital
      • Pensacola, Florida, Forente stater, 32504
        • Sacred Heart Hospital
      • St. Petersburg, Florida, Forente stater, 33701
        • Johns Hopkins All Children's Hospital
      • Tampa, Florida, Forente stater, 33612
        • Moffitt Cancer Center
      • Tampa, Florida, Forente stater, 33607
        • Moffitt Cancer Center-International Plaza
      • Tampa, Florida, Forente stater, 33607
        • Saint Joseph's Hospital/Children's Hospital-Tampa
      • Tampa, Florida, Forente stater, 33612
        • Moffitt Cancer Center - McKinley Campus
      • West Palm Beach, Florida, Forente stater, 33407
        • Saint Mary's Medical Center
    • Georgia
      • Atlanta, Georgia, Forente stater, 30322
        • Emory University Hospital/Winship Cancer Institute
      • Atlanta, Georgia, Forente stater, 30342
        • Emory Saint Joseph's Hospital
      • Atlanta, Georgia, Forente stater, 30329
        • Children's Healthcare of Atlanta - Arthur M Blank Hospital
      • Augusta, Georgia, Forente stater, 30912
        • Augusta University Medical Center
      • Savannah, Georgia, Forente stater, 31404
        • Memorial Health University Medical Center
    • Hawaii
      • Honolulu, Hawaii, Forente stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forente stater, 96817
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, Forente stater, 96813
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, Forente stater, 96813
        • Queen's Cancer Cenrer - POB I
      • Honolulu, Hawaii, Forente stater, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forente stater, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forente stater, 96817
        • Hawaii Cancer Care Inc-Liliha
      • Honolulu, Hawaii, Forente stater, 96817
        • Kuakini Medical Center
      • Honolulu, Hawaii, Forente stater, 96817
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, Forente stater, 96826
        • Kapiolani Medical Center for Women and Children
      • Lihue, Hawaii, Forente stater, 96766
        • Wilcox Memorial Hospital and Kauai Medical Clinic
      • ‘Aiea, Hawaii, Forente stater, 96701
        • Hawaii Cancer Care - Westridge
      • ‘Aiea, Hawaii, Forente stater, 96701
        • Pali Momi Medical Center
      • ‘Aiea, Hawaii, Forente stater, 96701
        • Queen's Cancer Center - Pearlridge
      • ‘Aiea, Hawaii, Forente stater, 96701
        • The Cancer Center of Hawaii-Pali Momi
    • Idaho
      • Boise, Idaho, Forente stater, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Boise, Idaho, Forente stater, 83712
        • Saint Luke's Cancer Institute - Boise
      • Caldwell, Idaho, Forente stater, 83605
        • Saint Alphonsus Cancer Care Center-Caldwell
      • Coeur d'Alene, Idaho, Forente stater, 83814
        • Kootenai Health - Coeur d'Alene
      • Fruitland, Idaho, Forente stater, 83619
        • Saint Luke's Cancer Institute - Fruitland
      • Meridian, Idaho, Forente stater, 83642
        • Idaho Urologic Institute-Meridian
      • Meridian, Idaho, Forente stater, 83642
        • Saint Luke's Cancer Institute - Meridian
      • Nampa, Idaho, Forente stater, 83687
        • Saint Alphonsus Cancer Care Center-Nampa
      • Nampa, Idaho, Forente stater, 83687
        • Saint Luke's Cancer Institute - Nampa
      • Post Falls, Idaho, Forente stater, 83854
        • Kootenai Clinic Cancer Services - Post Falls
      • Twin Falls, Idaho, Forente stater, 83301
        • Saint Luke's Cancer Institute - Twin Falls
    • Illinois
      • Aurora, Illinois, Forente stater, 60504
        • Rush-Copley Medical Center
      • Bloomington, Illinois, Forente stater, 61704
        • Illinois CancerCare-Bloomington
      • Canton, Illinois, Forente stater, 61520
        • Illinois CancerCare-Canton
      • Carbondale, Illinois, Forente stater, 62902
        • Memorial Hospital of Carbondale
      • Carterville, Illinois, Forente stater, 62918
        • SIH Cancer Institute
      • Carthage, Illinois, Forente stater, 62321
        • Illinois CancerCare-Carthage
      • Centralia, Illinois, Forente stater, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Forente stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forente stater, 60637
        • University of Chicago Comprehensive Cancer Center
      • Chicago, Illinois, Forente stater, 60612
        • University of Illinois
      • Chicago, Illinois, Forente stater, 60612
        • Rush MD Anderson Cancer Center
      • Danville, Illinois, Forente stater, 61832
        • Carle at The Riverfront
      • DeKalb, Illinois, Forente stater, 60115
        • Northwestern Medicine Cancer Center Kishwaukee
      • Decatur, Illinois, Forente stater, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forente stater, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Dixon, Illinois, Forente stater, 61021
        • Illinois CancerCare-Dixon
      • Effingham, Illinois, Forente stater, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, Forente stater, 62401
        • Carle Physician Group-Effingham
      • Eureka, Illinois, Forente stater, 61530
        • Illinois CancerCare-Eureka
      • Evanston, Illinois, Forente stater, 60201
        • NorthShore University HealthSystem-Evanston Hospital
      • Galesburg, Illinois, Forente stater, 61401
        • Western Illinois Cancer Treatment Center
      • Galesburg, Illinois, Forente stater, 61401
        • Illinois CancerCare-Galesburg
      • Geneva, Illinois, Forente stater, 60134
        • Northwestern Medicine Cancer Center Delnor
      • Glenview, Illinois, Forente stater, 60026
        • NorthShore University HealthSystem-Glenbrook Hospital
      • Harvey, Illinois, Forente stater, 60426
        • Ingalls Memorial Hospital
      • Highland Park, Illinois, Forente stater, 60035
        • NorthShore University HealthSystem-Highland Park Hospital
      • Hinsdale, Illinois, Forente stater, 60521
        • UChicago Medicine AdventHealth Cancer Institute Hinsdale
      • Joliet, Illinois, Forente stater, 60435
        • Duly Health and Care Joliet
      • Kewanee, Illinois, Forente stater, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Lake Forest, Illinois, Forente stater, 60045
        • Northwestern Medicine Lake Forest Hospital
      • Macomb, Illinois, Forente stater, 61455
        • Illinois CancerCare-Macomb
      • Mattoon, Illinois, Forente stater, 61938
        • Carle Physician Group-Mattoon/Charleston
      • Maywood, Illinois, Forente stater, 60153
        • Loyola University Medical Center
      • Mount Vernon, Illinois, Forente stater, 62864
        • SSM Health Good Samaritan
      • New Lenox, Illinois, Forente stater, 60451
        • UC Comprehensive Cancer Center at Silver Cross
      • O'Fallon, Illinois, Forente stater, 62269
        • Cancer Care Center of O'Fallon
      • Oak Lawn, Illinois, Forente stater, 60453
        • Advocate Children's Hospital-Oak Lawn
      • Orland Park, Illinois, Forente stater, 60462
        • University of Chicago Medicine-Orland Park
      • Ottawa, Illinois, Forente stater, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Park Ridge, Illinois, Forente stater, 60068
        • Advocate Children's Hospital-Park Ridge
      • Pekin, Illinois, Forente stater, 61554
        • Illinois CancerCare-Pekin
      • Pekin, Illinois, Forente stater, 61554
        • OSF Saint Francis Radiation Oncology at Pekin
      • Peoria, Illinois, Forente stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forente stater, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, Forente stater, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, Forente stater, 61615
        • OSF Saint Francis Radiation Oncology at Peoria Cancer Center
      • Peru, Illinois, Forente stater, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, Forente stater, 61354
        • Valley Radiation Oncology
      • Princeton, Illinois, Forente stater, 61356
        • Illinois CancerCare-Princeton
      • Springfield, Illinois, Forente stater, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Forente stater, 62702
        • Springfield Clinic
      • Springfield, Illinois, Forente stater, 62781
        • Springfield Memorial Hospital
      • Swansea, Illinois, Forente stater, 62226
        • Southwest Illinois Health Services LLP
      • Urbana, Illinois, Forente stater, 61801
        • Carle Cancer Center
      • Urbana, Illinois, Forente stater, 61801
        • The Carle Foundation Hospital
      • Warrenville, Illinois, Forente stater, 60555
        • Northwestern Medicine Cancer Center Warrenville
      • Washington, Illinois, Forente stater, 61571
        • Illinois CancerCare - Washington
    • Indiana
      • Fort Wayne, Indiana, Forente stater, 46845
        • Parkview Regional Medical Center
      • Indianapolis, Indiana, Forente stater, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Indianapolis, Indiana, Forente stater, 46202
        • Riley Hospital for Children
      • Indianapolis, Indiana, Forente stater, 46260
        • Ascension Saint Vincent Indianapolis Hospital
    • Iowa
      • Ames, Iowa, Forente stater, 50010
        • McFarland Clinic - Ames
      • Carroll, Iowa, Forente stater, 51401
        • Saint Anthony Regional Hospital
      • Cedar Rapids, Iowa, Forente stater, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Forente stater, 52403
        • Oncology Associates at Mercy Medical Center
      • Clive, Iowa, Forente stater, 50325
        • Mercy Cancer Center-West Lakes
      • Clive, Iowa, Forente stater, 50325
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
      • Creston, Iowa, Forente stater, 50801
        • Greater Regional Medical Center
      • Des Moines, Iowa, Forente stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forente stater, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forente stater, 50309
        • Blank Children's Hospital
      • Des Moines, Iowa, Forente stater, 50314
        • Broadlawns Medical Center
      • Des Moines, Iowa, Forente stater, 50316
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forente stater, 50309
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
      • Des Moines, Iowa, Forente stater, 50314
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
      • Iowa City, Iowa, Forente stater, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • West Des Moines, Iowa, Forente stater, 50266-7700
        • Methodist West Hospital
      • West Des Moines, Iowa, Forente stater, 50266
        • Mercy Medical Center-West Lakes
    • Kansas
      • Garden City, Kansas, Forente stater, 67846
        • Central Care Cancer Center - Garden City
      • Great Bend, Kansas, Forente stater, 67530
        • Central Care Cancer Center - Great Bend
      • Kansas City, Kansas, Forente stater, 66160
        • University of Kansas Cancer Center
      • Kansas City, Kansas, Forente stater, 66112
        • University of Kansas Cancer Center-West
      • Overland Park, Kansas, Forente stater, 66210
        • University of Kansas Cancer Center-Overland Park
      • Westwood, Kansas, Forente stater, 66205
        • University of Kansas Hospital-Westwood Cancer Center
    • Kentucky
      • Lexington, Kentucky, Forente stater, 40536
        • University of Kentucky/Markey Cancer Center
      • Lexington, Kentucky, Forente stater, 40504
        • Saint Joseph Radiation Oncology Resource Center
      • Lexington, Kentucky, Forente stater, 40509
        • CommonSpirit Saint Joseph Medical Center - East Lexington
      • Louisville, Kentucky, Forente stater, 40202
        • Jewish Hospital
      • Louisville, Kentucky, Forente stater, 40202
        • Norton Children's Hospital
      • Louisville, Kentucky, Forente stater, 40207
        • Norton Suburban Hospital and Medical Campus
      • Louisville, Kentucky, Forente stater, 40245
        • UofL Health Medical Center Northeast
    • Louisiana
      • Kenner, Louisiana, Forente stater, 70065
        • Ochsner Medical Center Kenner
      • New Orleans, Louisiana, Forente stater, 70121
        • Ochsner Medical Center Jefferson
      • New Orleans, Louisiana, Forente stater, 70118
        • Children's Hospital New Orleans
      • Shreveport, Louisiana, Forente stater, 71103
        • LSU Health Sciences Center at Shreveport
    • Maine
      • Augusta, Maine, Forente stater, 04330
        • Harold Alfond Center for Cancer Care
      • Bangor, Maine, Forente stater, 04401
        • Eastern Maine Medical Center
      • Bath, Maine, Forente stater, 04530
        • MaineHealth Coastal Cancer Treatment Center
      • Belfast, Maine, Forente stater, 04915
        • MaineHealth Waldo Hospital
      • Biddeford, Maine, Forente stater, 04005
        • MaineHealth Maine Medical Center - Biddeford
      • Portland, Maine, Forente stater, 04102
        • MaineHealth Maine Medical Center - Portland
      • Rockport, Maine, Forente stater, 04856
        • Penobscot Bay Medical Center
      • Sanford, Maine, Forente stater, 04073
        • MaineHealth Cancer Care Center of York County
      • Sanford, Maine, Forente stater, 04073
        • MaineHealth Cancer Care and IV Therapy - Sanford
      • Scarborough, Maine, Forente stater, 04074
        • MaineHealth Maine Medical Center- Scarborough
      • South Portland, Maine, Forente stater, 04106
        • MaineHealth Cancer Care and IV Therapy - South Portland
    • Maryland
      • Baltimore, Maryland, Forente stater, 21287
        • Johns Hopkins University/Sidney Kimmel Cancer Center
      • Baltimore, Maryland, Forente stater, 21215
        • Sinai Hospital of Baltimore
      • Baltimore, Maryland, Forente stater, 21201
        • University of Maryland/Greenebaum Cancer Center
      • Bel Air, Maryland, Forente stater, 21014
        • UM Upper Chesapeake Medical Center
      • Bethesda, Maryland, Forente stater, 20889-5600
        • Walter Reed National Military Medical Center
    • Massachusetts
      • Boston, Massachusetts, Forente stater, 02215
        • Dana-Farber Cancer Institute
      • Boston, Massachusetts, Forente stater, 02115
        • Brigham and Women's Hospital
      • Boston, Massachusetts, Forente stater, 02111
        • Tufts Medical Center
      • Boston, Massachusetts, Forente stater, 02118
        • Boston Medical Center
      • Boston, Massachusetts, Forente stater, 02114
        • Massachusetts General Hospital Cancer Center
      • Boston, Massachusetts, Forente stater, 02111
        • Tufts Children's Hospital
      • Springfield, Massachusetts, Forente stater, 01199
        • Baystate Medical Center
    • Michigan
      • Ann Arbor, Michigan, Forente stater, 48109
        • C S Mott Children's Hospital
      • Ann Arbor, Michigan, Forente stater, 48106
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
      • Battle Creek, Michigan, Forente stater, 49017
        • Bronson Battle Creek
      • Brighton, Michigan, Forente stater, 48114
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
      • Brighton, Michigan, Forente stater, 48114
        • Trinity Health Medical Center - Brighton
      • Brownstown, Michigan, Forente stater, 48183
        • Henry Ford Cancer Institute-Downriver
      • Canton, Michigan, Forente stater, 48188
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
      • Canton, Michigan, Forente stater, 48188
        • Trinity Health Medical Center - Canton
      • Chelsea, Michigan, Forente stater, 48118
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
      • Chelsea, Michigan, Forente stater, 48118
        • Chelsea Hospital
      • Clinton Township, Michigan, Forente stater, 48038
        • Henry Ford Macomb Hospital-Clinton Township
      • Dearborn, Michigan, Forente stater, 48126
        • Henry Ford Medical Center-Fairlane
      • Dearborn, Michigan, Forente stater, 48124
        • Corewell Health Dearborn Hospital
      • Detroit, Michigan, Forente stater, 48202
        • Henry Ford Hospital
      • Detroit, Michigan, Forente stater, 48201
        • Wayne State University/Karmanos Cancer Institute
      • Detroit, Michigan, Forente stater, 48236
        • Henry Ford Health Saint John Hospital
      • Farmington Hills, Michigan, Forente stater, 48334
        • Weisberg Cancer Treatment Center
      • Grand Rapids, Michigan, Forente stater, 49503
        • Trinity Health Grand Rapids Hospital
      • Grand Rapids, Michigan, Forente stater, 49503
        • Corewell Health Grand Rapids Hospitals - Butterworth Hospital
      • Grand Rapids, Michigan, Forente stater, 49503
        • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
      • Jackson, Michigan, Forente stater, 49201
        • Allegiance Health
      • Kalamazoo, Michigan, Forente stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forente stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forente stater, 49048
        • Beacon Kalamazoo
      • Livonia, Michigan, Forente stater, 48154
        • Trinity Health Saint Mary Mercy Livonia Hospital
      • Muskegon, Michigan, Forente stater, 49444
        • Trinity Health Muskegon Hospital
      • Niles, Michigan, Forente stater, 49120
        • Corewell Health Lakeland Hospitals - Niles Hospital
      • Norton Shores, Michigan, Forente stater, 49444
        • Cancer and Hematology Centers of Western Michigan - Norton Shores
      • Novi, Michigan, Forente stater, 48377
        • Henry Ford Medical Center-Columbus
      • Novi, Michigan, Forente stater, 48374
        • Henry Ford Health Providence Novi Hospital
      • Reed City, Michigan, Forente stater, 49677
        • Corewell Health Reed City Hospital
      • Royal Oak, Michigan, Forente stater, 48073
        • Corewell Health William Beaumont University Hospital
      • Royal Oak, Michigan, Forente stater, 48073
        • Corewell Health Children's
      • Saint Joseph, Michigan, Forente stater, 49085
        • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
      • Saint Joseph, Michigan, Forente stater, 49085
        • Corewell Health Lakeland Hospitals - Saint Joseph Hospital
      • Shelby, Michigan, Forente stater, 48315
        • Henry Ford Macomb Health Center - Shelby Township
      • Southfield, Michigan, Forente stater, 48075
        • Henry Ford Health Providence Southfield Hospital
      • Traverse City, Michigan, Forente stater, 49684
        • Munson Medical Center
      • Troy, Michigan, Forente stater, 48085
        • Corewell Health Beaumont Troy Hospital
      • West Bloomfield, Michigan, Forente stater, 48322
        • Henry Ford West Bloomfield Hospital
      • Wyoming, Michigan, Forente stater, 49519
        • University of Michigan Health - West
      • Ypsilanti, Michigan, Forente stater, 48197
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
    • Minnesota
      • Bemidji, Minnesota, Forente stater, 56601
        • Sanford Joe Lueken Cancer Center
      • Brainerd, Minnesota, Forente stater, 56401
        • Essentia Health Saint Joseph's Medical Center
      • Burnsville, Minnesota, Forente stater, 55337
        • Fairview Ridges Hospital
      • Burnsville, Minnesota, Forente stater, 55337
        • Minnesota Oncology - Burnsville
      • Coon Rapids, Minnesota, Forente stater, 55433
        • Mercy Hospital
      • Deer River, Minnesota, Forente stater, 56636
        • Essentia Health - Deer River Clinic
      • Detroit Lakes, Minnesota, Forente stater, 56501
        • Essentia Health Saint Mary's - Detroit Lakes Clinic
      • Duluth, Minnesota, Forente stater, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, Forente stater, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Forente stater, 55805
        • Miller-Dwan Hospital
      • Edina, Minnesota, Forente stater, 55435
        • Fairview Southdale Hospital
      • Fergus Falls, Minnesota, Forente stater, 56537
        • Lake Region Healthcare Corporation-Cancer Care
      • Fosston, Minnesota, Forente stater, 56542
        • Essentia Health - Fosston
      • Fridley, Minnesota, Forente stater, 55432
        • Unity Hospital
      • Hibbing, Minnesota, Forente stater, 55746
        • Essentia Health Hibbing Clinic
      • Maple Grove, Minnesota, Forente stater, 55369
        • Fairview Clinics and Surgery Center Maple Grove
      • Maplewood, Minnesota, Forente stater, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Forente stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forente stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forente stater, 55404
        • Children's Hospitals and Clinics of Minnesota - Minneapolis
      • Minneapolis, Minnesota, Forente stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forente stater, 55454
        • Health Partners Inc
      • Minneapolis, Minnesota, Forente stater, 55455
        • University of Minnesota/Masonic Cancer Center
      • Monticello, Minnesota, Forente stater, 55362
        • Monticello Cancer Center
      • Park Rapids, Minnesota, Forente stater, 56470
        • Essentia Health - Park Rapids
      • Robbinsdale, Minnesota, Forente stater, 55422
        • North Memorial Medical Health Center
      • Rochester, Minnesota, Forente stater, 55905
        • Mayo Clinic in Rochester
      • Saint Louis Park, Minnesota, Forente stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Forente stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forente stater, 55102
        • United Hospital
      • Sandstone, Minnesota, Forente stater, 55072
        • Essentia Health Sandstone
      • Shakopee, Minnesota, Forente stater, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forente stater, 55082
        • Lakeview Hospital
      • Virginia, Minnesota, Forente stater, 55792
        • Essentia Health Virginia Clinic
      • Waconia, Minnesota, Forente stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forente stater, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forente stater, 55125
        • Minnesota Oncology Hematology PA-Woodbury
    • Mississippi
      • Columbus, Mississippi, Forente stater, 39705
        • Baptist Memorial Hospital and Cancer Center-Golden Triangle
      • Grenada, Mississippi, Forente stater, 38901
        • Baptist Cancer Center-Grenada
      • Jackson, Mississippi, Forente stater, 39216
        • University of Mississippi Medical Center
      • New Albany, Mississippi, Forente stater, 38652
        • Baptist Memorial Hospital and Cancer Center-Union County
      • Oxford, Mississippi, Forente stater, 38655
        • Baptist Memorial Hospital and Cancer Center-Oxford
      • Southhaven, Mississippi, Forente stater, 38671
        • Baptist Memorial Hospital and Cancer Center-Desoto
    • Missouri
      • Ballwin, Missouri, Forente stater, 63011
        • Mercy Oncology and Hematology - Clayton-Clarkson
      • Bolivar, Missouri, Forente stater, 65613
        • Central Care Cancer Center - Bolivar
      • Bonne Terre, Missouri, Forente stater, 63628
        • Parkland Health Center-Bonne Terre
      • Cape Girardeau, Missouri, Forente stater, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Forente stater, 63703
        • Mercy Cancer Center - Cape Girardeau
      • City of Saint Peters, Missouri, Forente stater, 63376
        • Siteman Cancer Center at Saint Peters Hospital
      • Creve Coeur, Missouri, Forente stater, 63141
        • Siteman Cancer Center at West County Hospital
      • Farmington, Missouri, Forente stater, 63640
        • Parkland Health Center - Farmington
      • Jefferson City, Missouri, Forente stater, 65109
        • MU Health Care Goldschmidt Cancer Center
      • Joplin, Missouri, Forente stater, 64804
        • Freeman Health System
      • Joplin, Missouri, Forente stater, 64804
        • Mercy Hospital Joplin
      • Kansas City, Missouri, Forente stater, 64108
        • Children's Mercy Hospitals and Clinics
      • Kansas City, Missouri, Forente stater, 64154
        • University of Kansas Cancer Center - North
      • Lee's Summit, Missouri, Forente stater, 64064
        • University of Kansas Cancer Center - Lee's Summit
      • North Kansas City, Missouri, Forente stater, 64116
        • University of Kansas Cancer Center at North Kansas City Hospital
      • Rolla, Missouri, Forente stater, 65401
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Rolla, Missouri, Forente stater, 65401
        • Phelps Health Delbert Day Cancer Institute
      • Saint Joseph, Missouri, Forente stater, 64506
        • Heartland Regional Medical Center
      • Sainte Genevieve, Missouri, Forente stater, 63670
        • Sainte Genevieve County Memorial Hospital
      • Springfield, Missouri, Forente stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forente stater, 65804
        • Mercy Hospital Springfield
      • St Louis, Missouri, Forente stater, 63110
        • Washington University School of Medicine
      • St Louis, Missouri, Forente stater, 63129
        • Siteman Cancer Center-South County
      • St Louis, Missouri, Forente stater, 63136
        • Siteman Cancer Center at Christian Hospital
      • St Louis, Missouri, Forente stater, 63131
        • Missouri Baptist Medical Center
      • St Louis, Missouri, Forente stater, 63141
        • Mercy Hospital Saint Louis
      • St Louis, Missouri, Forente stater, 63128
        • Mercy Hospital South
      • St Louis, Missouri, Forente stater, 63104
        • Cardinal Glennon Children's Medical Center
      • Sullivan, Missouri, Forente stater, 63080
        • Missouri Baptist Sullivan Hospital
    • Montana
      • Billings, Montana, Forente stater, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, Forente stater, 59101
        • Saint Vincent Healthcare
      • Bozeman, Montana, Forente stater, 59715
        • Bozeman Health Deaconess Hospital
      • Butte, Montana, Forente stater, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Forente stater, 59405
        • Great Falls Clinic
      • Great Falls, Montana, Forente stater, 59405
        • Benefis Sletten Cancer Institute
      • Kalispell, Montana, Forente stater, 59901
        • Logan Health Medical Center
      • Missoula, Montana, Forente stater, 59804
        • Community Medical Center
    • Nebraska
      • Bellevue, Nebraska, Forente stater, 68123
        • Nebraska Medicine-Bellevue
      • Grand Island, Nebraska, Forente stater, 68803
        • Nebraska Cancer Specialists/Oncology Hematology West PC
      • Kearney, Nebraska, Forente stater, 68847
        • CHI Health Good Samaritan
      • Omaha, Nebraska, Forente stater, 68198
        • University of Nebraska Medical Center
      • Omaha, Nebraska, Forente stater, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Forente stater, 68118
        • Nebraska Medicine-Village Pointe
      • Omaha, Nebraska, Forente stater, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Forente stater, 68130
        • Alegent Health Lakeside Hospital
    • Nevada
      • Henderson, Nevada, Forente stater, 89052
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, Forente stater, 89074
        • Oncology Las Vegas - Henderson
      • Las Vegas, Nevada, Forente stater, 89102
        • OptumCare Cancer Care at Charleston
      • Las Vegas, Nevada, Forente stater, 89106
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, Forente stater, 89119
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, Forente stater, 89128
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, Forente stater, 89128
        • OptumCare Cancer Care at MountainView
      • Las Vegas, Nevada, Forente stater, 89135
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
      • Las Vegas, Nevada, Forente stater, 89144
        • Comprehensive Cancer Centers of Nevada - Town Center
      • Las Vegas, Nevada, Forente stater, 89144
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, Forente stater, 89148
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Forente stater, 89169
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Forente stater, 89183
        • OptumCare Cancer Care at Fort Apache
      • Reno, Nevada, Forente stater, 89502
        • Renown Regional Medical Center
      • Reno, Nevada, Forente stater, 89503
        • Saint Mary's Regional Medical Center
      • Reno, Nevada, Forente stater, 89509
        • Radiation Oncology Associates
      • Reno, Nevada, Forente stater, 89511
        • Cancer Care Specialists - Reno
    • New Hampshire
      • Lebanon, New Hampshire, Forente stater, 03756
        • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
      • Nashua, New Hampshire, Forente stater, 03063
        • Dartmouth Cancer Center - Nashua
    • New Jersey
      • Camden, New Jersey, Forente stater, 08103
        • Cooper Hospital University Medical Center
      • Hackensack, New Jersey, Forente stater, 07601
        • Hackensack University Medical Center
      • Livingston, New Jersey, Forente stater, 07039
        • Cooperman Barnabas Medical Center
      • Morristown, New Jersey, Forente stater, 07960
        • Morristown Medical Center
      • New Brunswick, New Jersey, Forente stater, 08903
        • Rutgers Cancer Institute of New Jersey
      • New Brunswick, New Jersey, Forente stater, 08901
        • Saint Peter's University Hospital
      • New Brunswick, New Jersey, Forente stater, 08903
        • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
      • Newark, New Jersey, Forente stater, 07101
        • Rutgers New Jersey Medical School
      • Newark, New Jersey, Forente stater, 07112
        • Newark Beth Israel Medical Center
      • Paramus, New Jersey, Forente stater, 07652
        • The Valley Hospital - Luckow Pavilion
      • Paterson, New Jersey, Forente stater, 07503
        • Saint Joseph's Regional Medical Center
      • Ridgewood, New Jersey, Forente stater, 07450
        • Valley Health System Ridgewood Campus
      • Summit, New Jersey, Forente stater, 07902
        • Overlook Hospital
      • Voorhees Township, New Jersey, Forente stater, 08043
        • MD Anderson Cancer Center at Cooper-Voorhees
      • Westwood, New Jersey, Forente stater, 07675
        • Valley Health System-Hematology/Oncology
    • New Mexico
      • Albuquerque, New Mexico, Forente stater, 87106
        • Presbyterian Hospital
      • Albuquerque, New Mexico, Forente stater, 87106
        • University of New Mexico Cancer Center
    • New York
      • Albany, New York, Forente stater, 12208
        • Albany Medical Center
      • Brooklyn, New York, Forente stater, 11215
        • New York-Presbyterian/Brooklyn Methodist Hospital
      • Buffalo, New York, Forente stater, 14263
        • Roswell Park Cancer Institute
      • Camillus, New York, Forente stater, 13031
        • Hematology Oncology Associates of CNY at Camillus
      • East Syracuse, New York, Forente stater, 13057
        • Hematology Oncology Associates of Central New York-East Syracuse
      • Glens Falls, New York, Forente stater, 12801
        • Glens Falls Hospital
      • New York, New York, Forente stater, 10065
        • Memorial Sloan Kettering Cancer Center
      • New York, New York, Forente stater, 10032
        • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
      • New York, New York, Forente stater, 10065
        • NYP/Weill Cornell Medical Center
      • Rochester, New York, Forente stater, 14642
        • University of Rochester
      • Stony Brook, New York, Forente stater, 11794
        • Stony Brook University Medical Center
      • Syracuse, New York, Forente stater, 13210
        • State University of New York Upstate Medical University
      • The Bronx, New York, Forente stater, 10467
        • Montefiore Medical Center - Moses Campus
    • North Carolina
      • Albemarle, North Carolina, Forente stater, 28002
        • Atrium Health Stanly/LCI-Albemarle
      • Chapel Hill, North Carolina, Forente stater, 27599
        • UNC Lineberger Comprehensive Cancer Center
      • Charlotte, North Carolina, Forente stater, 28203
        • Carolinas Medical Center/Levine Cancer Institute
      • Charlotte, North Carolina, Forente stater, 28204
        • Novant Health Presbyterian Medical Center
      • Charlotte, North Carolina, Forente stater, 28210
        • Atrium Health Pineville/LCI-Pineville
      • Charlotte, North Carolina, Forente stater, 28262
        • Atrium Health University City/LCI-University
      • Clemmons, North Carolina, Forente stater, 27012
        • Wake Forest University at Clemmons
      • Concord, North Carolina, Forente stater, 28025
        • Atrium Health Cabarrus/LCI-Concord
      • Durham, North Carolina, Forente stater, 27710
        • Duke University Medical Center
      • Greenville, North Carolina, Forente stater, 27834
        • East Carolina University
      • Kenansville, North Carolina, Forente stater, 28349
        • ECU Health Oncology Kenansville
      • Kernersville, North Carolina, Forente stater, 27284
        • Novant Health Cancer Institute - Kernersville
      • Kinston, North Carolina, Forente stater, 28501
        • ECU Health Oncology Kinston
      • Lincolnton, North Carolina, Forente stater, 28092
        • Atrium Health Lincoln/LCI-Lincolnton
      • Mount Airy, North Carolina, Forente stater, 27030
        • Novant Health Cancer Institute - Mount Airy
      • North Wilkesboro, North Carolina, Forente stater, 28659
        • Novant Health Cancer Institute - Wilkesboro
      • Pinehurst, North Carolina, Forente stater, 28374
        • FirstHealth of the Carolinas-Moore Regional Hospital
      • Richlands, North Carolina, Forente stater, 28574
        • ECU Health Oncology Richlands
      • Statesville, North Carolina, Forente stater, 28625
        • Novant Health Cancer Institute - Statesville
      • Thomasville, North Carolina, Forente stater, 27360
        • Novant Health Cancer Institute - Thomasville
      • Wilkesboro, North Carolina, Forente stater, 28659
        • Wake Forest Baptist Health - Wilkes Medical Center
      • Winston-Salem, North Carolina, Forente stater, 27157
        • Wake Forest University Health Sciences
      • Winston-Salem, North Carolina, Forente stater, 27103
        • Novant Health Forsyth Medical Center
    • North Dakota
      • Bismarck, North Dakota, Forente stater, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Forente stater, 58122
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Forente stater, 58103
        • Essentia Health Cancer Center-South University Clinic
      • Fargo, North Dakota, Forente stater, 58122
        • Sanford Broadway Medical Center
      • Jamestown, North Dakota, Forente stater, 58401
        • Essentia Health - Jamestown Clinic
    • Ohio
      • Akron, Ohio, Forente stater, 44308
        • Children's Hospital Medical Center of Akron
      • Canton, Ohio, Forente stater, 44708
        • Cleveland Clinic Mercy Hospital
      • Chillicothe, Ohio, Forente stater, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, Forente stater, 45229
        • Cincinnati Children's Hospital Medical Center
      • Cincinnati, Ohio, Forente stater, 45219
        • University of Cincinnati Cancer Center-UC Medical Center
      • Cincinnati, Ohio, Forente stater, 45220
        • Good Samaritan Hospital - Cincinnati
      • Cincinnati, Ohio, Forente stater, 45242
        • Bethesda North Hospital
      • Cleveland, Ohio, Forente stater, 44106
        • Case Western Reserve University
      • Cleveland, Ohio, Forente stater, 44109
        • MetroHealth Medical Center
      • Cleveland, Ohio, Forente stater, 44195
        • Cleveland Clinic Foundation
      • Cleveland, Ohio, Forente stater, 44106
        • Rainbow Babies and Childrens Hospital
      • Columbus, Ohio, Forente stater, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forente stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, Forente stater, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Forente stater, 43228
        • Doctors Hospital
      • Columbus, Ohio, Forente stater, 43213
        • Mount Carmel East Hospital
      • Columbus, Ohio, Forente stater, 43215
        • Grant Medical Center
      • Columbus, Ohio, Forente stater, 43222
        • Mount Carmel Health Center West
      • Delaware, Ohio, Forente stater, 43015
        • Delaware Health Center-Grady Cancer Center
      • Dublin, Ohio, Forente stater, 43016
        • Dublin Methodist Hospital
      • Lima, Ohio, Forente stater, 45801
        • Saint Rita's Medical Center
      • Mansfield, Ohio, Forente stater, 44903
        • OhioHealth Mansfield Hospital
      • Marietta, Ohio, Forente stater, 45750
        • Marietta Memorial Hospital
      • Newark, Ohio, Forente stater, 43055
        • Licking Memorial Hospital
      • Newark, Ohio, Forente stater, 43055
        • Newark Radiation Oncology
      • Portsmouth, Ohio, Forente stater, 45662
        • Southern Ohio Medical Center
      • Sylvania, Ohio, Forente stater, 43560
        • ProMedica Flower Hospital
      • Toledo, Ohio, Forente stater, 43606
        • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
      • Toledo, Ohio, Forente stater, 43623
        • Mercy Health - Saint Anne Hospital
      • Toledo, Ohio, Forente stater, 43623
        • Toledo Clinic Cancer Centers-Toledo
      • Toledo, Ohio, Forente stater, 43608
        • Mercy Health - Saint Vincent Hospital
      • West Chester, Ohio, Forente stater, 45069
        • University of Cincinnati Cancer Center-West Chester
      • Westerville, Ohio, Forente stater, 43081
        • Saint Ann's Hospital
      • Westlake, Ohio, Forente stater, 44145
        • UH Seidman Cancer Center at Saint John Medical Center
      • Zanesville, Ohio, Forente stater, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Lawton, Oklahoma, Forente stater, 73505
        • Cancer Centers of Southwest Oklahoma Research
      • Oklahoma City, Oklahoma, Forente stater, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Forente stater, 73120
        • Mercy Hospital Oklahoma City
    • Oregon
      • Bend, Oregon, Forente stater, 97701
        • Saint Charles Health System
      • Clackamas, Oregon, Forente stater, 97015
        • Clackamas Radiation Oncology Center
      • Clackamas, Oregon, Forente stater, 97015
        • Providence Cancer Institute Clackamas Clinic
      • Coos Bay, Oregon, Forente stater, 97420
        • Bay Area Hospital
      • Newberg, Oregon, Forente stater, 97132
        • Providence Newberg Medical Center
      • Portland, Oregon, Forente stater, 97239
        • Oregon Health and Science University
      • Portland, Oregon, Forente stater, 97213
        • Providence Portland Medical Center
      • Portland, Oregon, Forente stater, 97225
        • Providence Saint Vincent Medical Center
      • Portland, Oregon, Forente stater, 97227
        • Kaiser Permanente Northwest
      • Portland, Oregon, Forente stater, 97227
        • Legacy Emanuel Children's Hospital
    • Pennsylvania
      • Allentown, Pennsylvania, Forente stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bethlehem, Pennsylvania, Forente stater, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Chadds Ford, Pennsylvania, Forente stater, 19317
        • Christiana Care Health System-Concord Health Center
      • Danville, Pennsylvania, Forente stater, 17822
        • Geisinger Medical Center
      • Hazleton, Pennsylvania, Forente stater, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Lewisburg, Pennsylvania, Forente stater, 17837
        • Geisinger Medical Oncology-Lewisburg
      • Lewistown, Pennsylvania, Forente stater, 17044
        • Lewistown Hospital
      • Philadelphia, Pennsylvania, Forente stater, 19111
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, Forente stater, 19104
        • Children's Hospital of Philadelphia
      • Philadelphia, Pennsylvania, Forente stater, 19134
        • Saint Christopher's Hospital for Children
      • Pittsburgh, Pennsylvania, Forente stater, 15224
        • Children's Hospital of Pittsburgh of UPMC
      • Pottsville, Pennsylvania, Forente stater, 17901
        • Geisinger Cancer Services-Pottsville
      • Scranton, Pennsylvania, Forente stater, 18510
        • Community Medical Center
      • Selinsgrove, Pennsylvania, Forente stater, 17870
        • Geisinger Medical Oncology-Selinsgrove
      • West Reading, Pennsylvania, Forente stater, 19611
        • Reading Hospital
      • Wilkes-Barre, Pennsylvania, Forente stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
    • Rhode Island
      • Providence, Rhode Island, Forente stater, 02903
        • Rhode Island Hospital
    • South Carolina
      • Charleston, South Carolina, Forente stater, 29425
        • Medical University of South Carolina
      • Columbia, South Carolina, Forente stater, 29203
        • Prisma Health Richland Hospital
      • Gaffney, South Carolina, Forente stater, 29341
        • Gibbs Cancer Center-Gaffney
      • Greenville, South Carolina, Forente stater, 29605
        • Prisma Health Cancer Institute - Faris
      • Greenville, South Carolina, Forente stater, 29607
        • Saint Francis Cancer Center
      • Greenville, South Carolina, Forente stater, 29615
        • Prisma Health Cancer Institute - Eastside
      • Greenville, South Carolina, Forente stater, 29601
        • Saint Francis Hospital
      • Greenville, South Carolina, Forente stater, 29605
        • BI-LO Charities Children's Cancer Center
      • Greenville, South Carolina, Forente stater, 29605
        • Prisma Health Greenville Memorial Hospital
      • Greer, South Carolina, Forente stater, 29650
        • Prisma Health Cancer Institute - Greer
      • Greer, South Carolina, Forente stater, 29651
        • Gibbs Cancer Center-Pelham
      • Seneca, South Carolina, Forente stater, 29672
        • Prisma Health Cancer Institute - Seneca
      • Spartanburg, South Carolina, Forente stater, 29303
        • Spartanburg Medical Center
      • Union, South Carolina, Forente stater, 29379
        • SMC Center for Hematology Oncology Union
    • South Dakota
      • Sioux Falls, South Dakota, Forente stater, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Forente stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forente stater, 57104
        • Sanford Cancer Center Oncology Clinic
    • Tennessee
      • Chattanooga, Tennessee, Forente stater, 37403
        • T C Thompson Children's Hospital
      • Collierville, Tennessee, Forente stater, 38017
        • Baptist Memorial Hospital and Cancer Center-Collierville
      • Knoxville, Tennessee, Forente stater, 37916
        • East Tennessee Childrens Hospital
      • Memphis, Tennessee, Forente stater, 38120
        • Baptist Memorial Hospital and Cancer Center-Memphis
      • Nashville, Tennessee, Forente stater, 37232
        • Vanderbilt University/Ingram Cancer Center
      • Nashville, Tennessee, Forente stater, 37203
        • The Children's Hospital at TriStar Centennial
    • Texas
      • Austin, Texas, Forente stater, 78723
        • Dell Children's Medical Center of Central Texas
      • Bryan, Texas, Forente stater, 77802
        • Saint Joseph Regional Cancer Center
      • Corpus Christi, Texas, Forente stater, 78411
        • Driscoll Children's Hospital
      • Dallas, Texas, Forente stater, 75230
        • Medical City Dallas Hospital
      • Edinburg, Texas, Forente stater, 78539
        • STCC at DHR Health Institute for Research and Development
      • El Paso, Texas, Forente stater, 79905
        • El Paso Children's Hospital
      • Houston, Texas, Forente stater, 77030
        • UT MD Anderson Cancer Center
      • Houston, Texas, Forente stater, 77030
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
      • Lubbock, Texas, Forente stater, 79410
        • Covenant Children's Hospital
      • Lubbock, Texas, Forente stater, 79415
        • UMC Cancer Center / UMC Health System
      • San Antonio, Texas, Forente stater, 78229
        • University of Texas Health Science Center at San Antonio
      • San Antonio, Texas, Forente stater, 78207
        • Children's Hospital of San Antonio
      • San Antonio, Texas, Forente stater, 78229
        • Methodist Children's Hospital of South Texas
    • Utah
      • Cedar City, Utah, Forente stater, 84720
        • Sandra L Maxwell Cancer Center
      • Logan, Utah, Forente stater, 84321
        • Logan Regional Hospital
      • Murray, Utah, Forente stater, 84107
        • Intermountain Medical Center
      • Ogden, Utah, Forente stater, 84403
        • McKay-Dee Hospital Center
      • Provo, Utah, Forente stater, 84604
        • Utah Valley Regional Medical Center
      • Riverton, Utah, Forente stater, 84065
        • Riverton Hospital
      • Salt Lake City, Utah, Forente stater, 84112
        • Huntsman Cancer Institute/University of Utah
      • Salt Lake City, Utah, Forente stater, 84106
        • Utah Cancer Specialists-Salt Lake City
      • Salt Lake City, Utah, Forente stater, 84113
        • Primary Children's Hospital
      • Salt Lake City, Utah, Forente stater, 84143
        • LDS Hospital
      • St. George, Utah, Forente stater, 84770
        • Saint George Regional Medical Center
    • Vermont
      • Burlington, Vermont, Forente stater, 05405
        • University of Vermont and State Agricultural College
      • Saint Johnsbury, Vermont, Forente stater, 05819
        • Dartmouth Cancer Center - North
    • Virginia
      • Falls Church, Virginia, Forente stater, 22042
        • Inova Fairfax Hospital
      • Gloucester, Virginia, Forente stater, 23061
        • Peninsula Cancer Institute-Gloucester
      • Lynchburg, Virginia, Forente stater, 24501
        • Centra Alan B Pearson Regional Cancer Center
      • Newport News, Virginia, Forente stater, 23601
        • Peninsula Cancer Institute-Newport News
      • Norfolk, Virginia, Forente stater, 23507
        • Children's Hospital of The King's Daughters
      • Portsmouth, Virginia, Forente stater, 23708-2197
        • Naval Medical Center - Portsmouth
      • Richmond, Virginia, Forente stater, 23229
        • Virginia Cancer Institute
      • Richmond, Virginia, Forente stater, 23298
        • VCU Massey Comprehensive Cancer Center
      • Williamsburg, Virginia, Forente stater, 23185
        • Peninsula Cancer Institute-Williamsburg
    • Washington
      • Aberdeen, Washington, Forente stater, 98520
        • Providence Regional Cancer System-Aberdeen
      • Bellevue, Washington, Forente stater, 98004
        • Overlake Medical Center
      • Bellingham, Washington, Forente stater, 98225
        • PeaceHealth Saint Joseph Medical Center
      • Burien, Washington, Forente stater, 98166
        • Saint Anne Hospital
      • Centralia, Washington, Forente stater, 98531
        • Providence Regional Cancer System-Centralia
      • Edmonds, Washington, Forente stater, 98026
        • Swedish Cancer Institute-Edmonds
      • Everett, Washington, Forente stater, 98201
        • Providence Regional Cancer Partnership
      • Issaquah, Washington, Forente stater, 98029
        • Swedish Cancer Institute-Issaquah
      • Kennewick, Washington, Forente stater, 99336
        • Kadlec Clinic Hematology and Oncology
      • Lacey, Washington, Forente stater, 98503
        • Providence Regional Cancer System-Lacey
      • Longview, Washington, Forente stater, 98632
        • PeaceHealth Saint John Medical Center
      • Renton, Washington, Forente stater, 98055
        • Valley Medical Center
      • Seattle, Washington, Forente stater, 98105
        • Seattle Children's Hospital
      • Seattle, Washington, Forente stater, 98107
        • Swedish Medical Center-Ballard Campus
      • Seattle, Washington, Forente stater, 98122
        • Swedish Medical Center-First Hill
      • Seattle, Washington, Forente stater, 98195
        • University of Washington Medical Center - Montlake
      • Seattle, Washington, Forente stater, 98109
        • Fred Hutchinson Cancer Center
      • Sedro-Woolley, Washington, Forente stater, 98284
        • PeaceHealth United General Medical Center
      • Silverdale, Washington, Forente stater, 98383
        • Saint Joseph Medical Center Hematology and Oncology - Silverdale
      • Spokane, Washington, Forente stater, 99204
        • Providence Sacred Heart Medical Center and Children's Hospital
      • Tacoma, Washington, Forente stater, 98405
        • Mary Bridge Children's Hospital and Health Center
      • Tacoma, Washington, Forente stater, 98405
        • Northwest Medical Specialties PLLC
      • Tacoma, Washington, Forente stater, 98431
        • Madigan Army Medical Center
      • Vancouver, Washington, Forente stater, 98664
        • PeaceHealth Southwest Medical Center
      • Walla Walla, Washington, Forente stater, 99362
        • Providence Saint Mary Regional Cancer Center
      • Yakima, Washington, Forente stater, 98902
        • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
    • West Virginia
      • Charleston, West Virginia, Forente stater, 25304
        • Vandalia Health/CAMC Institute for Academic Medicine
    • Wisconsin
      • Appleton, Wisconsin, Forente stater, 54911
        • ThedaCare Regional Cancer Center
      • Appleton, Wisconsin, Forente stater, 54915
        • Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
      • Ashland, Wisconsin, Forente stater, 54806
        • Duluth Clinic Ashland
      • Ashland, Wisconsin, Forente stater, 54806
        • Northwest Wisconsin Cancer Center
      • Brookfield, Wisconsin, Forente stater, 53045
        • Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
      • Burlington, Wisconsin, Forente stater, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Chilton, Wisconsin, Forente stater, 53014
        • Ascension Calumet Hospital-Chilton
      • Eau Claire, Wisconsin, Forente stater, 54701
        • Marshfield Medical Center-EC Cancer Center
      • Eau Claire, Wisconsin, Forente stater, 54701
        • HSHS Sacred Heart Hospital
      • Eau Claire, Wisconsin, Forente stater, 54701
        • Mayo Clinic Health System-Eau Claire Clinic
      • Eau Claire, Wisconsin, Forente stater, 54703
        • Mayo Clinic Health System Eau Claire Hospital-Luther Campus
      • Franklin, Wisconsin, Forente stater, 53132
        • Ascension Southeast Wisconsin Hospital - Franklin
      • Franklin, Wisconsin, Forente stater, 53132
        • Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
      • Germantown, Wisconsin, Forente stater, 53022
        • Aurora Health Care Germantown Health Center
      • Grafton, Wisconsin, Forente stater, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Forente stater, 54311
        • Aurora BayCare Medical Center
      • Green Bay, Wisconsin, Forente stater, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, Forente stater, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Kenosha, Wisconsin, Forente stater, 53142
        • Aurora Cancer Care-Kenosha South
      • La Crosse, Wisconsin, Forente stater, 54601
        • Gundersen Lutheran Medical Center
      • Madison, Wisconsin, Forente stater, 53792
        • University of Wisconsin Carbone Cancer Center - University Hospital
      • Madison, Wisconsin, Forente stater, 53715
        • SSM Health Dean Medical Group - South Madison Campus
      • Marinette, Wisconsin, Forente stater, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marshfield, Wisconsin, Forente stater, 54449
        • Marshfield Medical Center-Marshfield
      • Mequon, Wisconsin, Forente stater, 53097
        • Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
      • Milwaukee, Wisconsin, Forente stater, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Forente stater, 53209
        • Aurora Cancer Care-Milwaukee
      • Milwaukee, Wisconsin, Forente stater, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Forente stater, 53233
        • Aurora Sinai Medical Center
      • Milwaukee, Wisconsin, Forente stater, 53210
        • Ascension Southeast Wisconsin Hospital-Saint Joseph-Milwaukee
      • Milwaukee, Wisconsin, Forente stater, 53211
        • Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
      • Milwaukee, Wisconsin, Forente stater, 53215
        • Ascension Saint Francis Hospital-Milwaukee
      • Minocqua, Wisconsin, Forente stater, 54548
        • Marshfield Medical Center - Minocqua
      • Mukwonago, Wisconsin, Forente stater, 53149
        • ProHealth D N Greenwald Center
      • New Berlin, Wisconsin, Forente stater, 53151
        • Froedtert and MCW Moorland Reserve Health Center
      • New Richmond, Wisconsin, Forente stater, 54017
        • Cancer Center of Western Wisconsin
      • Oconomowoc, Wisconsin, Forente stater, 53066
        • ProHealth Oconomowoc Memorial Hospital
      • Oconto Falls, Wisconsin, Forente stater, 54154
        • Saint Vincent Hospital Cancer Center at Oconto Falls
      • Oshkosh, Wisconsin, Forente stater, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Oshkosh, Wisconsin, Forente stater, 54904
        • Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
      • Racine, Wisconsin, Forente stater, 53406
        • Aurora Cancer Care-Racine
      • Racine, Wisconsin, Forente stater, 53405
        • Ascension All Saints Hospital-Spring Street-Racine
      • Rhinelander, Wisconsin, Forente stater, 54501
        • Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
      • Rice Lake, Wisconsin, Forente stater, 54868
        • Marshfield Medical Center-Rice Lake
      • Sheboygan, Wisconsin, Forente stater, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Stevens Point, Wisconsin, Forente stater, 54482
        • Marshfield Medical Center-River Region at Stevens Point
      • Stevens Point, Wisconsin, Forente stater, 54481
        • Aspirus Cancer Care - Stevens Point
      • Sturgeon Bay, Wisconsin, Forente stater, 54235-1495
        • Saint Vincent Hospital Cancer Center at Sturgeon Bay
      • Summit, Wisconsin, Forente stater, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Forente stater, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Waukesha, Wisconsin, Forente stater, 53188
        • UW Cancer Center at ProHealth Care
      • Wauwatosa, Wisconsin, Forente stater, 53226
        • Aurora Cancer Care-Milwaukee West
      • Wauwatosa, Wisconsin, Forente stater, 53226
        • Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
      • West Allis, Wisconsin, Forente stater, 53227
        • Aurora West Allis Medical Center
      • Weston, Wisconsin, Forente stater, 54476
        • Marshfield Medical Center - Weston
      • Wisconsin Rapids, Wisconsin, Forente stater, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
    • Wyoming
      • Sheridan, Wyoming, Forente stater, 82801
        • Welch Cancer Center
  • Puerto Rico
      • Caguas, Puerto Rico, 00726
        • HIMA San Pablo Oncologic Hospital
      • San Juan, Puerto Rico, 00926
        • University Pediatric Hospital

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

12 år og eldre (Barn, Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion Criteria:

  • All patients must have histologically confirmed newly diagnosed, previously untreated stage III or IV classical Hodgkin lymphoma (nodular sclerosing, mixed cellularity, lymphocyte-rich, or lymphocyte-depleted, or not otherwise specified [NOS]). Nodular lymphocyte predominant Hodgkin lymphoma is not eligible.

  • Patients must have bidimensionally measurable disease (at least one lesion with longest diameter >= 1.5 cm) documented on the Lymphoma Baseline Tumor Assessment Form in Rave.

  • Patients must have a whole body or limited whole body PET-CT scan performed within 42 days prior to registration. (A contrast-enhanced [diagnostic] CT, MRI or MR-PET is acceptable in event that PET-CT is contra-indicated, however if it is later possible to administer a PET-CT, then PET-CT is strongly preferred for the interim scan (after cycle 2) (if performed) and the EOT assessment. Otherwise, if PET-CT is not subsequently possible, then the same modality as baseline must be used throughout the trial.) NOTE: All images from PET-CT, CT, MRI or MR-PET scans performed as standard of care to assess disease (within 42 days prior to registration) must be submitted and associated radiology reports must be submitted.

  • Patients must be >= 12 years of age.

  • Patients must not have received any prior chemotherapy, radiation, or antibody-based treatment for classical Hodgkin lymphoma. Steroid pre-treatment is permitted.

  • Patients must not have had prior solid organ transplant.

  • Patients must not have had prior allogeneic stem cell transplantation.

  • Patients must not have received a live vaccine within 30 days prior to planned day 1 of protocol therapy (e.g. measles, mumps, rubella, varicella, yellow fever, rabies, Bacillus Calmette-Guerin [BCG], oral polio vaccine, and oral typhoid).

  • At registration, investigator must declare intent-to-treat with residual PET radiation therapy (residual PET RT- RPRT) to be administered after patient completes 6 cycles of therapy if, after end of treatment, the patient meets criteria specified for receiving RT). Patients will be stratified by investigator's intent-to-treat with residual PET RT.

    • All pediatric patients (< 18 years of age) will be considered intent-to-treat with Residual PET RT at time of registration.

  • Patients must have a performance status corresponding to Zubrod scores of 0, 1 or 2. Use Lansky for patients =< 17 years of age. *The conversion of the Lansky to Eastern Cooperative Oncology Group (ECOG) scales is intended for National Cancer Institute (NCI) reporting purposes only.

  • Adults (age 18 or older): Creatinine clearance >= 30 mL/min, as estimated by the Cockcroft and Gault formula. The creatinine value used in the calculation must have been obtained within 28 days prior to registration. Estimated creatinine clearance is based on actual body weight.

Pediatric Patients (age 12-17), the following must have been obtained within 14 days prior to registration:

  • Measured or calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2, or

  • Serum creatinine =< 1.5 x institutional upper limit of normal (IULN), or a serum creatinine (SCr) based on age/gender as follows:

    • Age < 13 maximum serum creatinine: Male 1.2 mg/dL; Female 1.2 mg/dL

    • Age 13 to < 16 maximum serum creatinine: Male 1.5 mg/dL; Female 1.4 mg/dL

    • Age 16-17 maximum serum creatinine: Male 1.7 mg/dL; Female 1.4 mg/dL

      • Total bilirubin =< 2 x IULN (must be documented within 28 days prior to registration for adults [age 18 or older]; must be documented within 14 days prior to registration for pediatric patients [age 12-17]).

  • Unless due to Gilbert's disease, lymphomatous involvement of liver or vanishing bile duct syndrome

    • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x IULN (must be documented within 28 days prior to registration for adults [age 18 or older]; must be documented within 14 days prior to registration for pediatric patients [age 12-17]).

  • Unless due to Gilbert's disease, lymphomatous involvement of liver or vanishing bile duct syndrome

    • Patients must have an echocardiogram (ECHO), multigated acquisition (MUGA), or functional cardiac imaging scan with a left ventricular ejection (LVEF) fraction >= 50% or a shortening fraction of >= 27%. For all patients, the ECHO, MUGA, or functional cardiac imaging scan must be performed within 42 days prior to registration.
    • Patients with known human immunodeficiency virus (HIV) infection must be receiving anti-retroviral therapy and have an undetectable or unquantifiable viral load at their most recent viral load test within 6 months prior to registration.
    • Patients must not have known active hepatitis B (HBV) or hepatitis C virus (HCV) at date of registration. Patients with previously treated HBV or HCV that have an undetectable viral load within 6 months prior to registration and no residual hepatic impairment are eligible.
    • Patients must not have any known central nervous system lymphoma.
    • Patients must not have a history of or active interstitial pneumonitis or interstitial lung disease.
    • Patients must not have had a diagnosis of inherited or acquired immunodeficiency.
    • Patients must not have any known uncontrolled intercurrent illness including, but not limited to symptomatic congestive heart failure, unstable angina pectoris, hemodynamically unstable cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
    • Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days prior to registration. Inhaled or topical steroids, and adrenal replacement doses > 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease. Steroid use for the control of Hodgkin lymphoma symptoms is allowable, but must be discontinued prior to cycle 1, day 1.
    • Patients with peripheral neuropathy must have < grade 2 at date of registration.
    • Patients must not have active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, immunosuppressive drugs, or corticosteroids with doses higher than prednisone 10 mg or equivalent). Autoimmune diseases include but are not limited to autoimmune hepatitis, inflammatory bowel disease (including ulcerative colitis and Crohn's disease), as well as symptomatic disease (e.g.: rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, autoimmune vasculitis [e.g., Wegener's granulomatosis]); central nervous system (CNS) or motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and myasthenia gravis, multiple sclerosis or glomerulonephritis). Vitiligo, alopecia, hypothyroidism on stable doses of thyroid replacement therapy, psoriasis not requiring systemic therapy within the past 2 years are permitted.
    • No second prior malignancy is allowed except for adequately treated basal (or squamous cell) skin cancer, any in situ cancer or other cancer for which the patient has been disease free for two years.
    • Females of childbearing potential must not be pregnant or nursing, and have a negative pregnancy test within 28 days prior to registration. Women/men of reproductive potential must have agreed to use an effective contraceptive method while receiving study drug and for women until 6 months after receiving the last dose of study drug or, for men, until 7 months after receiving the last dose of study drug. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures.
    • Patients must have one formalin-fixed paraffin embedded (FFPE) diagnostic tumor block or at least 1 diagnostic, 4-5 micron, hematoxylin and eosin (H&E) slide collected prior to registration and available for submission.
    • Patients must be offered participation in banking for planned translational medicine and future research. With patient consent, any residuals from the mandatory tissue submission will also be banked for future research.
    • Patients who can complete Patient-Reported Outcome instruments in English, Spanish, or French must complete the PROMIS Fatigue, the FACT/GOG-Ntx, and the PROMIS Global prior to registration. Patients who do not complete PRO instruments prior to registration but are otherwise eligible will remain eligible for the primary analysis and other secondary analyses.
    • Patients who can complete Patient-Reported Outcome instruments in English, Spanish, or French must also agree to complete the PROMIS Fatigue, the FACT/GOG-Ntx, the PROMIS Global, and the PRO-CTCAE (or Pediatric [Ped] PRO-CTCAE) at the scheduled on-study assessment timepoints.
    • Patients must be informed of the investigational nature of this study and all patients and/or their parents or legal guardians (for patients < 18 years of age) must sign and give informed consent and assent (where appropriate) in accordance with institutional and federal guidelines. For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board Initiative (CIRB) regulations.

  • Note: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Ingen (Open Label)

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: Arm I (chemotherapy, nivolumab, radiation)

Patients receive doxorubicin hydrochloride IV, vinblastine sulfate IV, dacarbazine IV, and nivolumab IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim SC on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician. Patients also undergo peripheral blood specimen collection and CT, PET/CT and MRI on study.
Annen: Quality-of-Life Assessment

Ancillary studies

Andre navn:
  • Livskvalitetsvurdering
Legemiddel: Doxorubicin Hydrochloride

Given IV

Andre navn:
  • Adriamycin
  • 5,12-naftacendion, 10-[(3-amino-2,3,6-trideoksy-alfa-L-lyxo-heksopyranosyl)oksy]-7,8, 9,10-tetrahydro-6,8,11-trihydroksy -8-(hydroksyacetyl)-1-metoksy-, hydroklorid, (8S-cis)- (9Cl)
  • ADM
  • Adriacin
  • Adriamycin hydroklorid
  • Adriamycin PFS
  • Adriamycin RDF
  • ADRIAMYCIN, HYDROKLORID
  • Adriblastina
  • Adriblastin
  • Adrimedac
  • Chloridrato de Doxorrubicina
  • DOX
  • DOXO-CELL
  • Doxolem
  • Doxorubicin HCl
  • Doxorubicin.HCl
  • Doxorubin
  • Farmiblastina
  • FI 106
  • FI-106
  • hydroksydaunorubicin
  • Rubex
  • FI106
Fremgangsmåte: Magnetic Resonance Imaging

Undergo MRI

Andre navn:
  • MR
  • Magnetisk resonans
  • Magnetic Resonance Imaging Scan
  • Medisinsk bildebehandling, magnetisk resonans / kjernemagnetisk resonans
  • MR Imaging
  • MR-skanning
  • NMR-avbildning
  • NMRI
  • Kjernemagnetisk resonansavbildning
  • Magnetisk resonanstomografi (MR)
  • sMRI
  • Magnetisk resonansavbildning (prosedyre)
  • MR-er
  • Strukturell MR
Annen: Questionnaire Administration

Ancillary studies

Biologisk: Nivolumab

Given IV

Andre navn:
  • BMS-936558
  • MDX-1106
  • NIVO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Nivolumab Biosimilar CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Nivolumab Biosimilar ABP 206
  • BCD-263
  • Nivolumab Biosimilar BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538
Biologisk: Filgrastim

Given SC or IV

Andre navn:
  • G-CSF
  • r-metHuG-CSF
  • Neupogen
  • Filgrastim-aafi
  • Nivestym
  • Rekombinant metionyl human granulocyttkolonistimulerende faktor
  • rG-CSF
  • Tevagrastim
  • Filgrastim Biosimilar Filgrastim-sndz
  • Zarxio
  • Filgrastim XM02
  • Tbo-filgrastim
  • Granix
  • Nivestim
  • XM02
  • Filgrastim-sndz
  • Filgrastim Biosimilar Tbo-filgrastim
  • Filgrastim-ayow
  • Releuko
  • Neutroval
Biologisk: Pegfilgrastim

Given SC

Andre navn:
  • Filgrastim SD-01
  • filgrastim-SD/01
  • Fulphila
  • HSP-130
  • Jinyouli
  • Neulasta
  • Neulastim
  • Nyvepria
  • PEG-filgrastim
  • Pegcyte
  • Pegfilgrastim Biosimilar HSP-130
  • Pegfilgrastim Biosimilar Nyvepria
  • Pegfilgrastim Biosimilar Pegcyte
  • Pegfilgrastim Biosimilar PF-06881894
  • Pegfilgrastim Biosimilar Udenyca
  • Pegfilgrastim Biosimilar Ziextenzo
  • Pegfilgrastim-jmdb
  • PF-06881894
  • SD-01
  • SD-01 vedvarende varighet G-CSF
  • Udenyca
  • Ziextenzo
  • Neupopeg
  • Pegylert G-CSF
  • Pegylert GCSF
  • Pegylert granulocyttkolonistimulerende faktor
  • Pegfilgrastim-apgf
  • Pegfilgrastim-bmez
  • Pegfilgrastim-cbqv
  • Dulastin
  • Tripegfilgrastim
  • Fylnetra
  • G-Lasta
  • Pegfilgrastim-fpgk
  • Pegfilgrastim-pbbk
  • Stimufeng
  • Pegfilgrastim-cegf
  • Pegfilgrastim-dyru
  • Pegfilgrastim-gras
  • Pegfilgrastim-pelg
  • Pegfilgrastim-pelm
  • Cegfila
  • Dyrupeg
  • Grasustek
  • Pelgraz
  • Pelmeg
Fremgangsmåte: Positron Emission Tomography

Undergo PET/CT scan

Andre navn:
  • Medisinsk bildebehandling, positronemisjonstomografi
  • KJÆLEDYR
  • PET-skanning
  • Positron Emission Tomography Scan
  • Positron-utslippstomografi
  • PT
  • Positronemisjonstomografi (prosedyre)
Fremgangsmåte: Biospecimen Collection

Undergo peripheral blood collection

Andre navn:
  • Biologisk prøvesamling
  • Bioprøve samlet
  • Prøvesamling
Fremgangsmåte: Computed Tomography

Undergo PET/CT or CT scan

Andre navn:
  • CT
  • KATT
  • CAT-skanning
  • Beregnet aksial tomografi
  • Datastyrt aksialtomografi
  • Datastyrt tomografi
  • CT skann
  • tomografi
  • Datastyrt aksial tomografi (prosedyre)
  • Datastyrt tomografi (CT) skanning
  • Diagnostisk CAT -skanning
  • Diagnostisk CAT -skannertype
Legemiddel: Dacarbazine

Given IV

Andre navn:
  • 4-(dimetyltriazeno)imidazol-5-karboksamid
  • 5-(dimetyltriazeno)imidazol-4-karboksamid
  • Asercit
  • Biokarbazin
  • Dacarbazina
  • Dacarbazina Almirall
  • Dacarbazin - DTIC
  • Dakatisk
  • Dakarbazin
  • Deticene
  • Detimedac
  • DIC
  • Dimetyl (triazeno) imidazolkarboksamid
  • Dimethyl Triazeno Imidazol Carboxamide
  • Dimethyl Triazeno Imidazole Carboxamide
  • dimetyl-triazeno-imidazol-karboksamid
  • Dimetyl-triazeno-imidazol-karboksimid
  • DTIC
  • DTIC-Dome
  • Feilaktig
  • Imidazol karboksamid
  • Imidazol Karboksamid Dimetyltriazeno
  • WR-139007
Stråling: Radiation Therapy

Receive radiation therapy

Andre navn:
  • Kreft Strålebehandling
  • ENERGY_TYPE
  • Bestråle
  • Bestrålt
  • Bestråling
  • Stråling
  • Stråleterapi, NOS
  • Radioterapeutika
  • Strålebehandling
  • RT
  • Terapi, stråling
  • Energitype
Legemiddel: Vinblastine Sulfate

Given IV

Andre navn:
  • 29060 LE
  • 29060-LE
  • Exal
  • Velban
  • Velbe
  • Velsar
  • VINCALEUKOBLASTINE
Eksperimentell: Arm II (chemotherapy, brentuximab vedotin, radiation)

Patients receive doxorubicin hydrochloride IV, vinblastine sulfate IV, dacarbazine IV, and brentuximab vedotin IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim SC on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician. Patients also undergo peripheral blood specimen collection and CT, PET/CT and MRI on study.
Annen: Quality-of-Life Assessment

Ancillary studies

Andre navn:
  • Livskvalitetsvurdering
Legemiddel: Doxorubicin Hydrochloride

Given IV

Andre navn:
  • Adriamycin
  • 5,12-naftacendion, 10-[(3-amino-2,3,6-trideoksy-alfa-L-lyxo-heksopyranosyl)oksy]-7,8, 9,10-tetrahydro-6,8,11-trihydroksy -8-(hydroksyacetyl)-1-metoksy-, hydroklorid, (8S-cis)- (9Cl)
  • ADM
  • Adriacin
  • Adriamycin hydroklorid
  • Adriamycin PFS
  • Adriamycin RDF
  • ADRIAMYCIN, HYDROKLORID
  • Adriblastina
  • Adriblastin
  • Adrimedac
  • Chloridrato de Doxorrubicina
  • DOX
  • DOXO-CELL
  • Doxolem
  • Doxorubicin HCl
  • Doxorubicin.HCl
  • Doxorubin
  • Farmiblastina
  • FI 106
  • FI-106
  • hydroksydaunorubicin
  • Rubex
  • FI106
Fremgangsmåte: Magnetic Resonance Imaging

Undergo MRI

Andre navn:
  • MR
  • Magnetisk resonans
  • Magnetic Resonance Imaging Scan
  • Medisinsk bildebehandling, magnetisk resonans / kjernemagnetisk resonans
  • MR Imaging
  • MR-skanning
  • NMR-avbildning
  • NMRI
  • Kjernemagnetisk resonansavbildning
  • Magnetisk resonanstomografi (MR)
  • sMRI
  • Magnetisk resonansavbildning (prosedyre)
  • MR-er
  • Strukturell MR
Annen: Questionnaire Administration

Ancillary studies

Legemiddel: Brentuximab Vedotin

Given IV

Andre navn:
  • Adcetris
  • SGN-35
  • cAC10-vcMMAE
  • ADC SGN-35
  • Anti-CD30 antistoff-medikamentkonjugat SGN-35
  • Anti-CD30 monoklonalt antistoff-MMAE SGN-35
  • Anti-CD30 Monoklonalt Antistoff-Monometylauristatin E SGN-35
  • SGN35
  • SGN 35
Biologisk: Filgrastim

Given SC or IV

Andre navn:
  • G-CSF
  • r-metHuG-CSF
  • Neupogen
  • Filgrastim-aafi
  • Nivestym
  • Rekombinant metionyl human granulocyttkolonistimulerende faktor
  • rG-CSF
  • Tevagrastim
  • Filgrastim Biosimilar Filgrastim-sndz
  • Zarxio
  • Filgrastim XM02
  • Tbo-filgrastim
  • Granix
  • Nivestim
  • XM02
  • Filgrastim-sndz
  • Filgrastim Biosimilar Tbo-filgrastim
  • Filgrastim-ayow
  • Releuko
  • Neutroval
Biologisk: Pegfilgrastim

Given SC

Andre navn:
  • Filgrastim SD-01
  • filgrastim-SD/01
  • Fulphila
  • HSP-130
  • Jinyouli
  • Neulasta
  • Neulastim
  • Nyvepria
  • PEG-filgrastim
  • Pegcyte
  • Pegfilgrastim Biosimilar HSP-130
  • Pegfilgrastim Biosimilar Nyvepria
  • Pegfilgrastim Biosimilar Pegcyte
  • Pegfilgrastim Biosimilar PF-06881894
  • Pegfilgrastim Biosimilar Udenyca
  • Pegfilgrastim Biosimilar Ziextenzo
  • Pegfilgrastim-jmdb
  • PF-06881894
  • SD-01
  • SD-01 vedvarende varighet G-CSF
  • Udenyca
  • Ziextenzo
  • Neupopeg
  • Pegylert G-CSF
  • Pegylert GCSF
  • Pegylert granulocyttkolonistimulerende faktor
  • Pegfilgrastim-apgf
  • Pegfilgrastim-bmez
  • Pegfilgrastim-cbqv
  • Dulastin
  • Tripegfilgrastim
  • Fylnetra
  • G-Lasta
  • Pegfilgrastim-fpgk
  • Pegfilgrastim-pbbk
  • Stimufeng
  • Pegfilgrastim-cegf
  • Pegfilgrastim-dyru
  • Pegfilgrastim-gras
  • Pegfilgrastim-pelg
  • Pegfilgrastim-pelm
  • Cegfila
  • Dyrupeg
  • Grasustek
  • Pelgraz
  • Pelmeg
Fremgangsmåte: Positron Emission Tomography

Undergo PET/CT scan

Andre navn:
  • Medisinsk bildebehandling, positronemisjonstomografi
  • KJÆLEDYR
  • PET-skanning
  • Positron Emission Tomography Scan
  • Positron-utslippstomografi
  • PT
  • Positronemisjonstomografi (prosedyre)
Fremgangsmåte: Biospecimen Collection

Undergo peripheral blood collection

Andre navn:
  • Biologisk prøvesamling
  • Bioprøve samlet
  • Prøvesamling
Fremgangsmåte: Computed Tomography

Undergo PET/CT or CT scan

Andre navn:
  • CT
  • KATT
  • CAT-skanning
  • Beregnet aksial tomografi
  • Datastyrt aksialtomografi
  • Datastyrt tomografi
  • CT skann
  • tomografi
  • Datastyrt aksial tomografi (prosedyre)
  • Datastyrt tomografi (CT) skanning
  • Diagnostisk CAT -skanning
  • Diagnostisk CAT -skannertype
Legemiddel: Dacarbazine

Given IV

Andre navn:
  • 4-(dimetyltriazeno)imidazol-5-karboksamid
  • 5-(dimetyltriazeno)imidazol-4-karboksamid
  • Asercit
  • Biokarbazin
  • Dacarbazina
  • Dacarbazina Almirall
  • Dacarbazin - DTIC
  • Dakatisk
  • Dakarbazin
  • Deticene
  • Detimedac
  • DIC
  • Dimetyl (triazeno) imidazolkarboksamid
  • Dimethyl Triazeno Imidazol Carboxamide
  • Dimethyl Triazeno Imidazole Carboxamide
  • dimetyl-triazeno-imidazol-karboksamid
  • Dimetyl-triazeno-imidazol-karboksimid
  • DTIC
  • DTIC-Dome
  • Feilaktig
  • Imidazol karboksamid
  • Imidazol Karboksamid Dimetyltriazeno
  • WR-139007
Stråling: Radiation Therapy

Receive radiation therapy

Andre navn:
  • Kreft Strålebehandling
  • ENERGY_TYPE
  • Bestråle
  • Bestrålt
  • Bestråling
  • Stråling
  • Stråleterapi, NOS
  • Radioterapeutika
  • Strålebehandling
  • RT
  • Terapi, stråling
  • Energitype
Legemiddel: Vinblastine Sulfate

Given IV

Andre navn:
  • 29060 LE
  • 29060-LE
  • Exal
  • Velban
  • Velbe
  • Velsar
  • VINCALEUKOBLASTINE

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Progression Free Survival (PFS)
Tidsramme: From date of registration to date of first observation of progressive disease, or death due to any cause, assessed at 2 years

Will be reported as the number of participants who have experienced death or progression, measured at two years. Progression will be measured according to the 2014 Lugano classification. Will test the null hypothesis (HR=1) for PFS using stratified log-rank test with a one-sided alpha of 0.021. The analysis will be based on modified intent-to-treat and will include all eligible patients as randomized regardless of treatment received. The one-sided alpha of .021 will control of the overall type-one error of the study (including the 2 interim superiority analyses) to be less than .025.
From date of registration to date of first observation of progressive disease, or death due to any cause, assessed at 2 years

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Overall Survival
Tidsramme: From date of registration to two years or death.

Will be reported as the count of participants who have died, measured at two years. Stratified log-rank test at two-sided alpha level of .05.
From date of registration to two years or death.
Event-free Survival (EFS)
Tidsramme: From date of registration to date of first occurrence of EFS event, assessed at 2 years

Will be reported as count of participants who have experienced an EFS event or death at two years.

EFS Events are defined as:

  • Disease progression/relapse
  • Administration of non-protocol specified systemic anti-lymphoma therapy (i.e. salvage therapy) at any time after initiation of protocol therapy.
  • Administration of any non-protocol specified radiation therapy at any time afterinitiation of protocol therapy Will be estimated using Kaplan-Meier method and compared between treatment arms using cox regression model.
From date of registration to date of first occurrence of EFS event, assessed at 2 years
Number of Participants With of Adverse Events
Tidsramme: Up to 2 years

Only adverse events that are possibly, probably or definitely related to study drug are reported.
Up to 2 years
Metabolic Complete Response Rate
Tidsramme: 4-8 weeks after last dose of study drug

This outcome measure will be reported by 11/5/2025.
4-8 weeks after last dose of study drug

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

National Cancer Institute (NCI)

Etterforskere

  • Hovedetterforsker: Alex F Herrera, SWOG Cancer Research Network

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

29. august 2019

Primær fullføring (Faktiske)

31. mars 2024

Studiet fullført (Antatt)

28. mars 2027

Datoer for studieregistrering

Først innsendt

8. april 2019

Først innsendt som oppfylte QC-kriteriene

8. april 2019

Først lagt ut (Faktiske)

9. april 2019

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

22. oktober 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

21. oktober 2026

Sist bekreftet

1. september 2026

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • NCI-2019-01960
  • NCI-2019-01960 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
  • S1826 (Annen identifikator: CTEP)
  • U10CA180888 (U.S. NIH-stipend/kontrakt)
  • S1826 (Annen identifikator: SWOG)

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

JA

IPD-planbeskrivelse

NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Ja

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Abonnere