Immunterapi (Nivolumab eller Brentuximab Vedotin) plus kombinationskemoterapi vid behandling av patienter med nyligen diagnostiserat stadium III-IV klassiskt Hodgkin-lymfom
21 oktober 2026 uppdaterad av: National Cancer Institute (NCI)
A Phase III, Randomized Study of Nivolumab (Opdivo) Plus AVD or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma
This phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Brentuximab vedotin is a monoclonal antibody, brentuximab, linked to a toxic agent called vedotin. Brentuximab attaches to cancer cells in a targeted way and delivers vedotin to kill them. Chemotherapy drugs, such as doxorubicin, vinblastine, and dacarbazine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The addition of nivolumab or brentuximab vedotin to combination chemotherapy may shrink the cancer or extend the time without disease symptoms coming back.
Studieöversikt
Status
Aktiv, inte rekryterande
Betingelser
- Ann Arbor stadium III Hodgkin lymfom
- Ann Arbor Stage III Lymfocyt-utarmad klassiskt Hodgkin-lymfom
- Ann Arbor Steg III blandad cellularitet Klassiskt Hodgkin-lymfom
- Ann Arbor Steg III Nodulär skleros Klassiskt Hodgkin-lymfom
- Ann Arbor stadium IV Hodgkin lymfom
- Ann Arbor Steg IV Lymfocyt-utarmad klassiskt Hodgkin-lymfom
- Ann Arbor Steg IV blandad cellularitet Klassiskt Hodgkin-lymfom
- Ann Arbor Steg IV Nodulär skleros Klassiskt Hodgkin-lymfom
- Klassiskt Hodgkin lymfom
- Lymfocytrikt klassiskt Hodgkin-lymfom
Intervention / Behandling
- Övrig: Quality-of-Life Assessment
- Läkemedel: Doxorubicin Hydrochloride
- Procedur: Magnetic Resonance Imaging
- Övrig: Questionnaire Administration
- Läkemedel: Brentuximab Vedotin
- Biologisk: Nivolumab
- Biologisk: Filgrastim
- Biologisk: Pegfilgrastim
- Procedur: Positron Emission Tomography
- Procedur: Biospecimen Collection
- Procedur: Computed Tomography
- Läkemedel: Dacarbazine
- Strålning: Radiation Therapy
- Läkemedel: Vinblastine Sulfate
Detaljerad beskrivning
PRIMARY OBJECTIVE:
I. To compare the progression-free survival (PFS) in patients with newly diagnosed advanced stage classical Hodgkin lymphoma randomized to N-AVD (nivolumab, doxorubicin hydrochloride [doxorubicin], vinblastine sulfate [vinblastine], dacarbazine) versus that obtained with BV-AVD (brentuximab vedotin, doxorubicin, vinblastine, dacarbazine).
SECONDARY OBJECTIVES:
I. To compare overall survival (OS) in patients randomized to N-AVD versus BV-AVD.
II. To compare event-free survival (EFS) in patients randomized to N-AVD versus BV-AVD.
III. To compare the metabolic complete response (CR) rate at the end of treatment in patients randomized to N-AVD versus BV-AVD.
IV. To compare the physician-reported treatment-related adverse event rates between arms stratified by age groups.
V. To compare patient-reported symptoms using selected Patient Reported Outcome Common Toxicity Criteria for Adverse Events (PRO-CTCAE) items between arms stratified by age groups.
VI. To compare the safety and tolerability of N-AVD versus that of BV-AVD.
QUALITY OF LIFE OBJECTIVE:
I. To compare between arms patient-reported fatigue, neuropathy and health-related quality of life over time (baseline, beginning of cycle 3, 4-8 weeks after the last dose of protocol therapy [following last dose of study drug or radiation therapy, whichever is later], and 1 and 3 years after randomization) using the Patient Reported Outcomes Measurement Information System (PROMIS)-Fatigue, the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), and the PROMIS Global, respectively.
BANKING OBJECTIVES:
I. To bank specimens for future correlative studies. II. To bank positron emission tomography (PET)-computed tomography (CT) images for future correlative studies.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive doxorubicin hydrochloride intravenously (IV), vinblastine sulfate IV, dacarbazine IV, and nivolumab IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim subcutaneously (SC) on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician. Patients also undergo peripheral blood specimen collection and CT, PET/CT and/or magnetic resonance imaging (MRI) on study.
ARM II: Patients receive doxorubicin hydrochloride IV, vinblastine sulfate IV, dacarbazine IV, and brentuximab vedotin IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim SC on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician. Patients also undergo peripheral blood specimen collection and CT, PET/CT and MRI on study.
After completion of study treatment and prior to disease progression, patients are followed up every 3 months for the first year, every 6 months for years 2 and 3, then annually until 10 years after registration. Patients are followed up at the time of progression and then annually until 10 years after registration. Patients who receive radiation therapy are followed up at 8-12 weeks after completion of radiation therapy.
Studietyp
Interventionell
Inskrivning (Faktisk)
994
Fas
- Fas 3
Kontakter och platser
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Studieorter
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Alabama
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Birmingham, Alabama, Förenta staterna, 35233
- University of Alabama at Birmingham Cancer Center
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Birmingham, Alabama, Förenta staterna, 35233
- Children's Hospital of Alabama
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Mobile, Alabama, Förenta staterna, 36604
- USA Health Strada Patient Care Center
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Mobile, Alabama, Förenta staterna, 36688
- University of South Alabama Mitchell Cancer Institute
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Alaska
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Anchorage, Alaska, Förenta staterna, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Förenta staterna, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Förenta staterna, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Förenta staterna, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Förenta staterna, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Förenta staterna, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Förenta staterna, 99508
- Providence Alaska Medical Center
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Fairbanks, Alaska, Förenta staterna, 99701
- Fairbanks Memorial Hospital
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Arizona
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Goodyear, Arizona, Förenta staterna, 85338
- CTCA at Western Regional Medical Center
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Phoenix, Arizona, Förenta staterna, 85004
- Cancer Center at Saint Joseph's
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Phoenix, Arizona, Förenta staterna, 85016
- Phoenix Childrens Hospital
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Tucson, Arizona, Förenta staterna, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, Förenta staterna, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Förenta staterna, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Fort Smith, Arkansas, Förenta staterna, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Förenta staterna, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Jonesboro, Arkansas, Förenta staterna, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, Förenta staterna, 72205
- University of Arkansas for Medical Sciences
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Little Rock, Arkansas, Förenta staterna, 72202-3591
- Arkansas Children's Hospital
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California
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Anaheim, California, Förenta staterna, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, Förenta staterna, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Förenta staterna, 93420
- PCR Oncology
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Baldwin Park, California, Förenta staterna, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Förenta staterna, 90706
- Kaiser Permanente-Bellflower
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Beverly Hills, California, Förenta staterna, 90211
- Tower Cancer Research Foundation
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Burbank, California, Förenta staterna, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Duarte, California, Förenta staterna, 91010
- City of Hope Comprehensive Cancer Center
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Dublin, California, Förenta staterna, 94568
- Kaiser Permanente Dublin
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Fontana, California, Förenta staterna, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Förenta staterna, 94538
- Kaiser Permanente-Fremont
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Fresno, California, Förenta staterna, 93720
- Kaiser Permanente-Fresno
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Harbor City, California, Förenta staterna, 90710
- Kaiser Permanente South Bay
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Irvine, California, Förenta staterna, 92618
- Kaiser Permanente-Irvine
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La Jolla, California, Förenta staterna, 92093
- UC San Diego Moores Cancer Center
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Loma Linda, California, Förenta staterna, 92354
- Loma Linda University Medical Center
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Los Angeles, California, Förenta staterna, 90048
- Cedars-Sinai Medical Center
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Los Angeles, California, Förenta staterna, 90027
- Children's Hospital Los Angeles
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Los Angeles, California, Förenta staterna, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Förenta staterna, 90034
- Kaiser Permanente West Los Angeles
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Madera, California, Förenta staterna, 93636
- Valley Children's Hospital
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Marysville, California, Förenta staterna, 95901
- Fremont - Rideout Cancer Center
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Modesto, California, Förenta staterna, 95356
- Kaiser Permanente-Modesto
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Oakland, California, Förenta staterna, 94611
- Kaiser Permanente-Oakland
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Ontario, California, Förenta staterna, 91761
- Kaiser Permanente-Ontario
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Orange, California, Förenta staterna, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Orange, California, Förenta staterna, 92868
- Children's Hospital of Orange County
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Palm Springs, California, Förenta staterna, 92262
- Desert Regional Medical Center
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Palo Alto, California, Förenta staterna, 94304
- Stanford Cancer Institute Palo Alto
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Panorama City, California, Förenta staterna, 91402
- Kaiser Permanente - Panorama City
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Richmond, California, Förenta staterna, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Förenta staterna, 92505
- Kaiser Permanente-Riverside
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Sacramento, California, Förenta staterna, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Förenta staterna, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Förenta staterna, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, Förenta staterna, 95823
- Kaiser Permanente-South Sacramento
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San Diego, California, Förenta staterna, 92123
- Rady Children's Hospital - San Diego
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San Diego, California, Förenta staterna, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Förenta staterna, 92134
- Naval Medical Center -San Diego
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San Francisco, California, Förenta staterna, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Förenta staterna, 94158
- UCSF Medical Center-Mission Bay
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San Jose, California, Förenta staterna, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Förenta staterna, 94577
- Kaiser Permanente San Leandro
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San Luis Obispo, California, Förenta staterna, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Marcos, California, Förenta staterna, 92078
- Kaiser Permanente-San Marcos
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San Rafael, California, Förenta staterna, 94903
- Kaiser San Rafael-Gallinas
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Santa Maria, California, Förenta staterna, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Förenta staterna, 95403
- Kaiser Permanente-Santa Rosa
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South San Francisco, California, Förenta staterna, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Förenta staterna, 95210
- Kaiser Permanente-Stockton
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Torrance, California, Förenta staterna, 90502
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
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Vacaville, California, Förenta staterna, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Förenta staterna, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, Förenta staterna, 94596
- Kaiser Permanente-Walnut Creek
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Whittier, California, Förenta staterna, 90602
- Presbyterian Intercommunity Hospital
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Woodland Hills, California, Förenta staterna, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Förenta staterna, 80045
- Children's Hospital Colorado
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Aurora, Colorado, Förenta staterna, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Förenta staterna, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Förenta staterna, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, Förenta staterna, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Förenta staterna, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, Förenta staterna, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Förenta staterna, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, Förenta staterna, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Förenta staterna, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Förenta staterna, 80218
- Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
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Denver, Colorado, Förenta staterna, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Förenta staterna, 80210
- AdventHealth Porter
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Englewood, Colorado, Förenta staterna, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Förenta staterna, 80113
- Swedish Medical Center
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Grand Junction, Colorado, Förenta staterna, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, Förenta staterna, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Förenta staterna, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, Förenta staterna, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, Förenta staterna, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Förenta staterna, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Förenta staterna, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, Förenta staterna, 80124
- Sky Ridge Medical Center
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Longmont, Colorado, Förenta staterna, 80501
- Longmont United Hospital
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Loveland, Colorado, Förenta staterna, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Förenta staterna, 80138
- AdventHealth Parker
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Pueblo, Colorado, Förenta staterna, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Förenta staterna, 80260
- Rocky Mountain Cancer Centers-Thornton
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Wheat Ridge, Colorado, Förenta staterna, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Derby, Connecticut, Förenta staterna, 06418
- Smilow Cancer Hospital-Derby Care Center
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Hartford, Connecticut, Förenta staterna, 06106
- Connecticut Children's Medical Center
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New Haven, Connecticut, Förenta staterna, 06520
- Yale University
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New Haven, Connecticut, Förenta staterna, 06510
- Smilow Cancer Center/Yale-New Haven Hospital
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Orange, Connecticut, Förenta staterna, 06477
- Smilow Cancer Hospital-Orange Care Center
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Trumbull, Connecticut, Förenta staterna, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterford, Connecticut, Förenta staterna, 06385
- Smilow Cancer Hospital Care Center - Waterford
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Delaware
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Lewes, Delaware, Förenta staterna, 19958
- Beebe Medical Center
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Millville, Delaware, Förenta staterna, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, Förenta staterna, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Förenta staterna, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Förenta staterna, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Förenta staterna, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Förenta staterna, 19971
- Beebe Health Campus
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Seaford, Delaware, Förenta staterna, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Förenta staterna, 19803
- Alfred I duPont Hospital for Children
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District of Columbia
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Washington D.C., District of Columbia, Förenta staterna, 20010
- Children's National Medical Center
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Washington D.C., District of Columbia, Förenta staterna, 20007
- MedStar Georgetown University Hospital
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Florida
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Coral Gables, Florida, Förenta staterna, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Fort Lauderdale, Florida, Förenta staterna, 33316
- Broward Health Medical Center
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Fort Myers, Florida, Förenta staterna, 33905
- Regional Cancer Center-Lee Memorial Health System
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Fort Myers, Florida, Förenta staterna, 33908
- Golisano Children's Hospital of Southwest Florida
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Gainesville, Florida, Förenta staterna, 32610
- UF Health Cancer Institute - Gainesville
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Hollywood, Florida, Förenta staterna, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
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Hollywood, Florida, Förenta staterna, 33021
- UM Sylvester Comprehensive Cancer Center at Hollywood
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Jacksonville, Florida, Förenta staterna, 32207
- Nemours Children's Clinic-Jacksonville
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Loxahatchee Groves, Florida, Förenta staterna, 33470
- Palms West Radiation Therapy
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Miami, Florida, Förenta staterna, 33155
- Nicklaus Children's Hospital
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Miami, Florida, Förenta staterna, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, Förenta staterna, 33176
- Miami Cancer Institute
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Miami Beach, Florida, Förenta staterna, 33140
- Mount Sinai Medical Center
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Orlando, Florida, Förenta staterna, 32806
- Orlando Health Cancer Institute
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Orlando, Florida, Förenta staterna, 32827
- Nemours Children's Hospital
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Pensacola, Florida, Förenta staterna, 32504
- Sacred Heart Hospital
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St. Petersburg, Florida, Förenta staterna, 33701
- Johns Hopkins All Children's Hospital
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Tampa, Florida, Förenta staterna, 33612
- Moffitt Cancer Center
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Tampa, Florida, Förenta staterna, 33607
- Moffitt Cancer Center-International Plaza
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Tampa, Florida, Förenta staterna, 33607
- Saint Joseph's Hospital/Children's Hospital-Tampa
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Tampa, Florida, Förenta staterna, 33612
- Moffitt Cancer Center - McKinley Campus
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West Palm Beach, Florida, Förenta staterna, 33407
- Saint Mary's Medical Center
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Georgia
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Atlanta, Georgia, Förenta staterna, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Förenta staterna, 30342
- Emory Saint Joseph's Hospital
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Atlanta, Georgia, Förenta staterna, 30329
- Children's Healthcare of Atlanta - Arthur M Blank Hospital
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Augusta, Georgia, Förenta staterna, 30912
- Augusta University Medical Center
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Savannah, Georgia, Förenta staterna, 31404
- Memorial Health University Medical Center
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Hawaii
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Honolulu, Hawaii, Förenta staterna, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Förenta staterna, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Förenta staterna, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Förenta staterna, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Förenta staterna, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Förenta staterna, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Förenta staterna, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Förenta staterna, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Förenta staterna, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Förenta staterna, 96826
- Kapiolani Medical Center for Women and Children
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Lihue, Hawaii, Förenta staterna, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Förenta staterna, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, Förenta staterna, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Förenta staterna, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Förenta staterna, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, Förenta staterna, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Förenta staterna, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Förenta staterna, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Förenta staterna, 83814
- Kootenai Health - Coeur d'Alene
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Fruitland, Idaho, Förenta staterna, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Förenta staterna, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Förenta staterna, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Förenta staterna, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, Förenta staterna, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, Förenta staterna, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Twin Falls, Idaho, Förenta staterna, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, Förenta staterna, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, Förenta staterna, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, Förenta staterna, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Förenta staterna, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Förenta staterna, 62918
- SIH Cancer Institute
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Carthage, Illinois, Förenta staterna, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Förenta staterna, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Förenta staterna, 60611
- Northwestern University
-
Chicago, Illinois, Förenta staterna, 60637
- University of Chicago Comprehensive Cancer Center
-
Chicago, Illinois, Förenta staterna, 60612
- University of Illinois
-
Chicago, Illinois, Förenta staterna, 60612
- Rush MD Anderson Cancer Center
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Danville, Illinois, Förenta staterna, 61832
- Carle at The Riverfront
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DeKalb, Illinois, Förenta staterna, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Förenta staterna, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Förenta staterna, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Förenta staterna, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, Förenta staterna, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Förenta staterna, 62401
- Carle Physician Group-Effingham
-
Eureka, Illinois, Förenta staterna, 61530
- Illinois CancerCare-Eureka
-
Evanston, Illinois, Förenta staterna, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, Förenta staterna, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Förenta staterna, 61401
- Illinois CancerCare-Galesburg
-
Geneva, Illinois, Förenta staterna, 60134
- Northwestern Medicine Cancer Center Delnor
-
Glenview, Illinois, Förenta staterna, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
-
Harvey, Illinois, Förenta staterna, 60426
- Ingalls Memorial Hospital
-
Highland Park, Illinois, Förenta staterna, 60035
- NorthShore University HealthSystem-Highland Park Hospital
-
Hinsdale, Illinois, Förenta staterna, 60521
- UChicago Medicine AdventHealth Cancer Institute Hinsdale
-
Joliet, Illinois, Förenta staterna, 60435
- Duly Health and Care Joliet
-
Kewanee, Illinois, Förenta staterna, 61443
- Illinois CancerCare-Kewanee Clinic
-
Lake Forest, Illinois, Förenta staterna, 60045
- Northwestern Medicine Lake Forest Hospital
-
Macomb, Illinois, Förenta staterna, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Förenta staterna, 61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood, Illinois, Förenta staterna, 60153
- Loyola University Medical Center
-
Mount Vernon, Illinois, Förenta staterna, 62864
- SSM Health Good Samaritan
-
New Lenox, Illinois, Förenta staterna, 60451
- UC Comprehensive Cancer Center at Silver Cross
-
O'Fallon, Illinois, Förenta staterna, 62269
- Cancer Care Center of O'Fallon
-
Oak Lawn, Illinois, Förenta staterna, 60453
- Advocate Children's Hospital-Oak Lawn
-
Orland Park, Illinois, Förenta staterna, 60462
- University of Chicago Medicine-Orland Park
-
Ottawa, Illinois, Förenta staterna, 61350
- Illinois CancerCare-Ottawa Clinic
-
Park Ridge, Illinois, Förenta staterna, 60068
- Advocate Children's Hospital-Park Ridge
-
Pekin, Illinois, Förenta staterna, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Förenta staterna, 61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria, Illinois, Förenta staterna, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Förenta staterna, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Förenta staterna, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Förenta staterna, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Förenta staterna, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Förenta staterna, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Förenta staterna, 61356
- Illinois CancerCare-Princeton
-
Springfield, Illinois, Förenta staterna, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Förenta staterna, 62702
- Springfield Clinic
-
Springfield, Illinois, Förenta staterna, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, Förenta staterna, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Förenta staterna, 61801
- Carle Cancer Center
-
Urbana, Illinois, Förenta staterna, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Förenta staterna, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Washington, Illinois, Förenta staterna, 61571
- Illinois CancerCare - Washington
-
-
Indiana
-
Fort Wayne, Indiana, Förenta staterna, 46845
- Parkview Regional Medical Center
-
Indianapolis, Indiana, Förenta staterna, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Indianapolis, Indiana, Förenta staterna, 46202
- Riley Hospital for Children
-
Indianapolis, Indiana, Förenta staterna, 46260
- Ascension Saint Vincent Indianapolis Hospital
-
-
Iowa
-
Ames, Iowa, Förenta staterna, 50010
- McFarland Clinic - Ames
-
Carroll, Iowa, Förenta staterna, 51401
- Saint Anthony Regional Hospital
-
Cedar Rapids, Iowa, Förenta staterna, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Förenta staterna, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, Förenta staterna, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Förenta staterna, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Creston, Iowa, Förenta staterna, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Förenta staterna, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Förenta staterna, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Förenta staterna, 50309
- Blank Children's Hospital
-
Des Moines, Iowa, Förenta staterna, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Förenta staterna, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Förenta staterna, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Förenta staterna, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Iowa City, Iowa, Förenta staterna, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
West Des Moines, Iowa, Förenta staterna, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Förenta staterna, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Garden City, Kansas, Förenta staterna, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Förenta staterna, 67530
- Central Care Cancer Center - Great Bend
-
Kansas City, Kansas, Förenta staterna, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Förenta staterna, 66112
- University of Kansas Cancer Center-West
-
Overland Park, Kansas, Förenta staterna, 66210
- University of Kansas Cancer Center-Overland Park
-
Westwood, Kansas, Förenta staterna, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
-
Kentucky
-
Lexington, Kentucky, Förenta staterna, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Förenta staterna, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Förenta staterna, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
Louisville, Kentucky, Förenta staterna, 40202
- Jewish Hospital
-
Louisville, Kentucky, Förenta staterna, 40202
- Norton Children's Hospital
-
Louisville, Kentucky, Förenta staterna, 40207
- Norton Suburban Hospital and Medical Campus
-
Louisville, Kentucky, Förenta staterna, 40245
- UofL Health Medical Center Northeast
-
-
Louisiana
-
Kenner, Louisiana, Förenta staterna, 70065
- Ochsner Medical Center Kenner
-
New Orleans, Louisiana, Förenta staterna, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Förenta staterna, 70118
- Children's Hospital New Orleans
-
Shreveport, Louisiana, Förenta staterna, 71103
- LSU Health Sciences Center at Shreveport
-
-
Maine
-
Augusta, Maine, Förenta staterna, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Förenta staterna, 04401
- Eastern Maine Medical Center
-
Bath, Maine, Förenta staterna, 04530
- MaineHealth Coastal Cancer Treatment Center
-
Belfast, Maine, Förenta staterna, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, Förenta staterna, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Portland, Maine, Förenta staterna, 04102
- MaineHealth Maine Medical Center - Portland
-
Rockport, Maine, Förenta staterna, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Förenta staterna, 04073
- MaineHealth Cancer Care Center of York County
-
Sanford, Maine, Förenta staterna, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
Scarborough, Maine, Förenta staterna, 04074
- MaineHealth Maine Medical Center- Scarborough
-
South Portland, Maine, Förenta staterna, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Maryland
-
Baltimore, Maryland, Förenta staterna, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, Förenta staterna, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, Förenta staterna, 21201
- University of Maryland/Greenebaum Cancer Center
-
Bel Air, Maryland, Förenta staterna, 21014
- UM Upper Chesapeake Medical Center
-
Bethesda, Maryland, Förenta staterna, 20889-5600
- Walter Reed National Military Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, Förenta staterna, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Förenta staterna, 02115
- Brigham and Women's Hospital
-
Boston, Massachusetts, Förenta staterna, 02111
- Tufts Medical Center
-
Boston, Massachusetts, Förenta staterna, 02118
- Boston Medical Center
-
Boston, Massachusetts, Förenta staterna, 02114
- Massachusetts General Hospital Cancer Center
-
Boston, Massachusetts, Förenta staterna, 02111
- Tufts Children's Hospital
-
Springfield, Massachusetts, Förenta staterna, 01199
- Baystate Medical Center
-
-
Michigan
-
Ann Arbor, Michigan, Förenta staterna, 48109
- C S Mott Children's Hospital
-
Ann Arbor, Michigan, Förenta staterna, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Förenta staterna, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Förenta staterna, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Förenta staterna, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Förenta staterna, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Förenta staterna, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Förenta staterna, 48188
- Trinity Health Medical Center - Canton
-
Chelsea, Michigan, Förenta staterna, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Förenta staterna, 48118
- Chelsea Hospital
-
Clinton Township, Michigan, Förenta staterna, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, Förenta staterna, 48126
- Henry Ford Medical Center-Fairlane
-
Dearborn, Michigan, Förenta staterna, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Förenta staterna, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Förenta staterna, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Förenta staterna, 48236
- Henry Ford Health Saint John Hospital
-
Farmington Hills, Michigan, Förenta staterna, 48334
- Weisberg Cancer Treatment Center
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Jackson, Michigan, Förenta staterna, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Förenta staterna, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Förenta staterna, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Förenta staterna, 49048
- Beacon Kalamazoo
-
Livonia, Michigan, Förenta staterna, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Muskegon, Michigan, Förenta staterna, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Förenta staterna, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, Förenta staterna, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi, Michigan, Förenta staterna, 48377
- Henry Ford Medical Center-Columbus
-
Novi, Michigan, Förenta staterna, 48374
- Henry Ford Health Providence Novi Hospital
-
Reed City, Michigan, Förenta staterna, 49677
- Corewell Health Reed City Hospital
-
Royal Oak, Michigan, Förenta staterna, 48073
- Corewell Health William Beaumont University Hospital
-
Royal Oak, Michigan, Förenta staterna, 48073
- Corewell Health Children's
-
Saint Joseph, Michigan, Förenta staterna, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Förenta staterna, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Shelby, Michigan, Förenta staterna, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Southfield, Michigan, Förenta staterna, 48075
- Henry Ford Health Providence Southfield Hospital
-
Traverse City, Michigan, Förenta staterna, 49684
- Munson Medical Center
-
Troy, Michigan, Förenta staterna, 48085
- Corewell Health Beaumont Troy Hospital
-
West Bloomfield, Michigan, Förenta staterna, 48322
- Henry Ford West Bloomfield Hospital
-
Wyoming, Michigan, Förenta staterna, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Förenta staterna, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
-
Minnesota
-
Bemidji, Minnesota, Förenta staterna, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Förenta staterna, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Förenta staterna, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Förenta staterna, 55337
- Minnesota Oncology - Burnsville
-
Coon Rapids, Minnesota, Förenta staterna, 55433
- Mercy Hospital
-
Deer River, Minnesota, Förenta staterna, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Förenta staterna, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Förenta staterna, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Förenta staterna, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Förenta staterna, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Förenta staterna, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Förenta staterna, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Förenta staterna, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Förenta staterna, 55432
- Unity Hospital
-
Hibbing, Minnesota, Förenta staterna, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, Förenta staterna, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Förenta staterna, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Förenta staterna, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Förenta staterna, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Förenta staterna, 55404
- Children's Hospitals and Clinics of Minnesota - Minneapolis
-
Minneapolis, Minnesota, Förenta staterna, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Förenta staterna, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Förenta staterna, 55455
- University of Minnesota/Masonic Cancer Center
-
Monticello, Minnesota, Förenta staterna, 55362
- Monticello Cancer Center
-
Park Rapids, Minnesota, Förenta staterna, 56470
- Essentia Health - Park Rapids
-
Robbinsdale, Minnesota, Förenta staterna, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Förenta staterna, 55905
- Mayo Clinic in Rochester
-
Saint Louis Park, Minnesota, Förenta staterna, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Förenta staterna, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Förenta staterna, 55102
- United Hospital
-
Sandstone, Minnesota, Förenta staterna, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Förenta staterna, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Förenta staterna, 55082
- Lakeview Hospital
-
Virginia, Minnesota, Förenta staterna, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Förenta staterna, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Förenta staterna, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Förenta staterna, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Columbus, Mississippi, Förenta staterna, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Förenta staterna, 38901
- Baptist Cancer Center-Grenada
-
Jackson, Mississippi, Förenta staterna, 39216
- University of Mississippi Medical Center
-
New Albany, Mississippi, Förenta staterna, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Förenta staterna, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, Förenta staterna, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Förenta staterna, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Förenta staterna, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Förenta staterna, 63628
- Parkland Health Center-Bonne Terre
-
Cape Girardeau, Missouri, Förenta staterna, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Förenta staterna, 63703
- Mercy Cancer Center - Cape Girardeau
-
City of Saint Peters, Missouri, Förenta staterna, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Creve Coeur, Missouri, Förenta staterna, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Förenta staterna, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Förenta staterna, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Förenta staterna, 64804
- Freeman Health System
-
Joplin, Missouri, Förenta staterna, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Förenta staterna, 64108
- Children's Mercy Hospitals and Clinics
-
Kansas City, Missouri, Förenta staterna, 64154
- University of Kansas Cancer Center - North
-
Lee's Summit, Missouri, Förenta staterna, 64064
- University of Kansas Cancer Center - Lee's Summit
-
North Kansas City, Missouri, Förenta staterna, 64116
- University of Kansas Cancer Center at North Kansas City Hospital
-
Rolla, Missouri, Förenta staterna, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Förenta staterna, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Förenta staterna, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Förenta staterna, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Förenta staterna, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Förenta staterna, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Förenta staterna, 63110
- Washington University School of Medicine
-
St Louis, Missouri, Förenta staterna, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, Förenta staterna, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, Förenta staterna, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Förenta staterna, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Förenta staterna, 63128
- Mercy Hospital South
-
St Louis, Missouri, Förenta staterna, 63104
- Cardinal Glennon Children's Medical Center
-
Sullivan, Missouri, Förenta staterna, 63080
- Missouri Baptist Sullivan Hospital
-
-
Montana
-
Billings, Montana, Förenta staterna, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Förenta staterna, 59101
- Saint Vincent Healthcare
-
Bozeman, Montana, Förenta staterna, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Förenta staterna, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Förenta staterna, 59405
- Great Falls Clinic
-
Great Falls, Montana, Förenta staterna, 59405
- Benefis Sletten Cancer Institute
-
Kalispell, Montana, Förenta staterna, 59901
- Logan Health Medical Center
-
Missoula, Montana, Förenta staterna, 59804
- Community Medical Center
-
-
Nebraska
-
Bellevue, Nebraska, Förenta staterna, 68123
- Nebraska Medicine-Bellevue
-
Grand Island, Nebraska, Förenta staterna, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Förenta staterna, 68847
- CHI Health Good Samaritan
-
Omaha, Nebraska, Förenta staterna, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Förenta staterna, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Förenta staterna, 68118
- Nebraska Medicine-Village Pointe
-
Omaha, Nebraska, Förenta staterna, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Förenta staterna, 68130
- Alegent Health Lakeside Hospital
-
-
Nevada
-
Henderson, Nevada, Förenta staterna, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Förenta staterna, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Förenta staterna, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Förenta staterna, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Förenta staterna, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Förenta staterna, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Förenta staterna, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Förenta staterna, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Förenta staterna, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Förenta staterna, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Förenta staterna, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Förenta staterna, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Förenta staterna, 89183
- OptumCare Cancer Care at Fort Apache
-
Reno, Nevada, Förenta staterna, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Förenta staterna, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Förenta staterna, 89509
- Radiation Oncology Associates
-
Reno, Nevada, Förenta staterna, 89511
- Cancer Care Specialists - Reno
-
-
New Hampshire
-
Lebanon, New Hampshire, Förenta staterna, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Nashua, New Hampshire, Förenta staterna, 03063
- Dartmouth Cancer Center - Nashua
-
-
New Jersey
-
Camden, New Jersey, Förenta staterna, 08103
- Cooper Hospital University Medical Center
-
Hackensack, New Jersey, Förenta staterna, 07601
- Hackensack University Medical Center
-
Livingston, New Jersey, Förenta staterna, 07039
- Cooperman Barnabas Medical Center
-
Morristown, New Jersey, Förenta staterna, 07960
- Morristown Medical Center
-
New Brunswick, New Jersey, Förenta staterna, 08903
- Rutgers Cancer Institute of New Jersey
-
New Brunswick, New Jersey, Förenta staterna, 08901
- Saint Peter's University Hospital
-
New Brunswick, New Jersey, Förenta staterna, 08903
- Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
-
Newark, New Jersey, Förenta staterna, 07101
- Rutgers New Jersey Medical School
-
Newark, New Jersey, Förenta staterna, 07112
- Newark Beth Israel Medical Center
-
Paramus, New Jersey, Förenta staterna, 07652
- The Valley Hospital - Luckow Pavilion
-
Paterson, New Jersey, Förenta staterna, 07503
- Saint Joseph's Regional Medical Center
-
Ridgewood, New Jersey, Förenta staterna, 07450
- Valley Health System Ridgewood Campus
-
Summit, New Jersey, Förenta staterna, 07902
- Overlook Hospital
-
Voorhees Township, New Jersey, Förenta staterna, 08043
- MD Anderson Cancer Center at Cooper-Voorhees
-
Westwood, New Jersey, Förenta staterna, 07675
- Valley Health System-Hematology/Oncology
-
-
New Mexico
-
Albuquerque, New Mexico, Förenta staterna, 87106
- Presbyterian Hospital
-
Albuquerque, New Mexico, Förenta staterna, 87106
- University of New Mexico Cancer Center
-
-
New York
-
Albany, New York, Förenta staterna, 12208
- Albany Medical Center
-
Brooklyn, New York, Förenta staterna, 11215
- New York-Presbyterian/Brooklyn Methodist Hospital
-
Buffalo, New York, Förenta staterna, 14263
- Roswell Park Cancer Institute
-
Camillus, New York, Förenta staterna, 13031
- Hematology Oncology Associates of CNY at Camillus
-
East Syracuse, New York, Förenta staterna, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, Förenta staterna, 12801
- Glens Falls Hospital
-
New York, New York, Förenta staterna, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, Förenta staterna, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, Förenta staterna, 10065
- NYP/Weill Cornell Medical Center
-
Rochester, New York, Förenta staterna, 14642
- University of Rochester
-
Stony Brook, New York, Förenta staterna, 11794
- Stony Brook University Medical Center
-
Syracuse, New York, Förenta staterna, 13210
- State University of New York Upstate Medical University
-
The Bronx, New York, Förenta staterna, 10467
- Montefiore Medical Center - Moses Campus
-
-
North Carolina
-
Albemarle, North Carolina, Förenta staterna, 28002
- Atrium Health Stanly/LCI-Albemarle
-
Chapel Hill, North Carolina, Förenta staterna, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, Förenta staterna, 28203
- Carolinas Medical Center/Levine Cancer Institute
-
Charlotte, North Carolina, Förenta staterna, 28204
- Novant Health Presbyterian Medical Center
-
Charlotte, North Carolina, Förenta staterna, 28210
- Atrium Health Pineville/LCI-Pineville
-
Charlotte, North Carolina, Förenta staterna, 28262
- Atrium Health University City/LCI-University
-
Clemmons, North Carolina, Förenta staterna, 27012
- Wake Forest University at Clemmons
-
Concord, North Carolina, Förenta staterna, 28025
- Atrium Health Cabarrus/LCI-Concord
-
Durham, North Carolina, Förenta staterna, 27710
- Duke University Medical Center
-
Greenville, North Carolina, Förenta staterna, 27834
- East Carolina University
-
Kenansville, North Carolina, Förenta staterna, 28349
- ECU Health Oncology Kenansville
-
Kernersville, North Carolina, Förenta staterna, 27284
- Novant Health Cancer Institute - Kernersville
-
Kinston, North Carolina, Förenta staterna, 28501
- ECU Health Oncology Kinston
-
Lincolnton, North Carolina, Förenta staterna, 28092
- Atrium Health Lincoln/LCI-Lincolnton
-
Mount Airy, North Carolina, Förenta staterna, 27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro, North Carolina, Förenta staterna, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Pinehurst, North Carolina, Förenta staterna, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Richlands, North Carolina, Förenta staterna, 28574
- ECU Health Oncology Richlands
-
Statesville, North Carolina, Förenta staterna, 28625
- Novant Health Cancer Institute - Statesville
-
Thomasville, North Carolina, Förenta staterna, 27360
- Novant Health Cancer Institute - Thomasville
-
Wilkesboro, North Carolina, Förenta staterna, 28659
- Wake Forest Baptist Health - Wilkes Medical Center
-
Winston-Salem, North Carolina, Förenta staterna, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, Förenta staterna, 27103
- Novant Health Forsyth Medical Center
-
-
North Dakota
-
Bismarck, North Dakota, Förenta staterna, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Förenta staterna, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Förenta staterna, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Förenta staterna, 58122
- Sanford Broadway Medical Center
-
Jamestown, North Dakota, Förenta staterna, 58401
- Essentia Health - Jamestown Clinic
-
-
Ohio
-
Akron, Ohio, Förenta staterna, 44308
- Children's Hospital Medical Center of Akron
-
Canton, Ohio, Förenta staterna, 44708
- Cleveland Clinic Mercy Hospital
-
Chillicothe, Ohio, Förenta staterna, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Förenta staterna, 45229
- Cincinnati Children's Hospital Medical Center
-
Cincinnati, Ohio, Förenta staterna, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Förenta staterna, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Förenta staterna, 45242
- Bethesda North Hospital
-
Cleveland, Ohio, Förenta staterna, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Förenta staterna, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Förenta staterna, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Förenta staterna, 44106
- Rainbow Babies and Childrens Hospital
-
Columbus, Ohio, Förenta staterna, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Förenta staterna, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Förenta staterna, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Förenta staterna, 43228
- Doctors Hospital
-
Columbus, Ohio, Förenta staterna, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Förenta staterna, 43215
- Grant Medical Center
-
Columbus, Ohio, Förenta staterna, 43222
- Mount Carmel Health Center West
-
Delaware, Ohio, Förenta staterna, 43015
- Delaware Health Center-Grady Cancer Center
-
Dublin, Ohio, Förenta staterna, 43016
- Dublin Methodist Hospital
-
Lima, Ohio, Förenta staterna, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Förenta staterna, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Förenta staterna, 45750
- Marietta Memorial Hospital
-
Newark, Ohio, Förenta staterna, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Förenta staterna, 43055
- Newark Radiation Oncology
-
Portsmouth, Ohio, Förenta staterna, 45662
- Southern Ohio Medical Center
-
Sylvania, Ohio, Förenta staterna, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Förenta staterna, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, Förenta staterna, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Förenta staterna, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Förenta staterna, 43608
- Mercy Health - Saint Vincent Hospital
-
West Chester, Ohio, Förenta staterna, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Förenta staterna, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, Förenta staterna, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Zanesville, Ohio, Förenta staterna, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Förenta staterna, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Förenta staterna, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Förenta staterna, 73120
- Mercy Hospital Oklahoma City
-
-
Oregon
-
Bend, Oregon, Förenta staterna, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Förenta staterna, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Förenta staterna, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Förenta staterna, 97420
- Bay Area Hospital
-
Newberg, Oregon, Förenta staterna, 97132
- Providence Newberg Medical Center
-
Portland, Oregon, Förenta staterna, 97239
- Oregon Health and Science University
-
Portland, Oregon, Förenta staterna, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Förenta staterna, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Förenta staterna, 97227
- Kaiser Permanente Northwest
-
Portland, Oregon, Förenta staterna, 97227
- Legacy Emanuel Children's Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, Förenta staterna, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Förenta staterna, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Chadds Ford, Pennsylvania, Förenta staterna, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, Förenta staterna, 17822
- Geisinger Medical Center
-
Hazleton, Pennsylvania, Förenta staterna, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Lewisburg, Pennsylvania, Förenta staterna, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Förenta staterna, 17044
- Lewistown Hospital
-
Philadelphia, Pennsylvania, Förenta staterna, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Förenta staterna, 19104
- Children's Hospital of Philadelphia
-
Philadelphia, Pennsylvania, Förenta staterna, 19134
- Saint Christopher's Hospital for Children
-
Pittsburgh, Pennsylvania, Förenta staterna, 15224
- Children's Hospital of Pittsburgh of UPMC
-
Pottsville, Pennsylvania, Förenta staterna, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Förenta staterna, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Förenta staterna, 17870
- Geisinger Medical Oncology-Selinsgrove
-
West Reading, Pennsylvania, Förenta staterna, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Förenta staterna, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
-
Rhode Island
-
Providence, Rhode Island, Förenta staterna, 02903
- Rhode Island Hospital
-
-
South Carolina
-
Charleston, South Carolina, Förenta staterna, 29425
- Medical University of South Carolina
-
Columbia, South Carolina, Förenta staterna, 29203
- Prisma Health Richland Hospital
-
Gaffney, South Carolina, Förenta staterna, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Förenta staterna, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Förenta staterna, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Förenta staterna, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Förenta staterna, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Förenta staterna, 29605
- BI-LO Charities Children's Cancer Center
-
Greenville, South Carolina, Förenta staterna, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, Förenta staterna, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Förenta staterna, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, Förenta staterna, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Förenta staterna, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Förenta staterna, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Sioux Falls, South Dakota, Förenta staterna, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Förenta staterna, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Förenta staterna, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, Förenta staterna, 37403
- T C Thompson Children's Hospital
-
Collierville, Tennessee, Förenta staterna, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Knoxville, Tennessee, Förenta staterna, 37916
- East Tennessee Childrens Hospital
-
Memphis, Tennessee, Förenta staterna, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Nashville, Tennessee, Förenta staterna, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, Förenta staterna, 37203
- The Children's Hospital at TriStar Centennial
-
-
Texas
-
Austin, Texas, Förenta staterna, 78723
- Dell Children's Medical Center of Central Texas
-
Bryan, Texas, Förenta staterna, 77802
- Saint Joseph Regional Cancer Center
-
Corpus Christi, Texas, Förenta staterna, 78411
- Driscoll Children's Hospital
-
Dallas, Texas, Förenta staterna, 75230
- Medical City Dallas Hospital
-
Edinburg, Texas, Förenta staterna, 78539
- STCC at DHR Health Institute for Research and Development
-
El Paso, Texas, Förenta staterna, 79905
- El Paso Children's Hospital
-
Houston, Texas, Förenta staterna, 77030
- UT MD Anderson Cancer Center
-
Houston, Texas, Förenta staterna, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Lubbock, Texas, Förenta staterna, 79410
- Covenant Children's Hospital
-
Lubbock, Texas, Förenta staterna, 79415
- UMC Cancer Center / UMC Health System
-
San Antonio, Texas, Förenta staterna, 78229
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Förenta staterna, 78207
- Children's Hospital of San Antonio
-
San Antonio, Texas, Förenta staterna, 78229
- Methodist Children's Hospital of South Texas
-
-
Utah
-
Cedar City, Utah, Förenta staterna, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Förenta staterna, 84321
- Logan Regional Hospital
-
Murray, Utah, Förenta staterna, 84107
- Intermountain Medical Center
-
Ogden, Utah, Förenta staterna, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Förenta staterna, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Förenta staterna, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Förenta staterna, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Förenta staterna, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Förenta staterna, 84113
- Primary Children's Hospital
-
Salt Lake City, Utah, Förenta staterna, 84143
- LDS Hospital
-
St. George, Utah, Förenta staterna, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Burlington, Vermont, Förenta staterna, 05405
- University of Vermont and State Agricultural College
-
Saint Johnsbury, Vermont, Förenta staterna, 05819
- Dartmouth Cancer Center - North
-
-
Virginia
-
Falls Church, Virginia, Förenta staterna, 22042
- Inova Fairfax Hospital
-
Gloucester, Virginia, Förenta staterna, 23061
- Peninsula Cancer Institute-Gloucester
-
Lynchburg, Virginia, Förenta staterna, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Newport News, Virginia, Förenta staterna, 23601
- Peninsula Cancer Institute-Newport News
-
Norfolk, Virginia, Förenta staterna, 23507
- Children's Hospital of The King's Daughters
-
Portsmouth, Virginia, Förenta staterna, 23708-2197
- Naval Medical Center - Portsmouth
-
Richmond, Virginia, Förenta staterna, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Förenta staterna, 23298
- VCU Massey Comprehensive Cancer Center
-
Williamsburg, Virginia, Förenta staterna, 23185
- Peninsula Cancer Institute-Williamsburg
-
-
Washington
-
Aberdeen, Washington, Förenta staterna, 98520
- Providence Regional Cancer System-Aberdeen
-
Bellevue, Washington, Förenta staterna, 98004
- Overlake Medical Center
-
Bellingham, Washington, Förenta staterna, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Förenta staterna, 98166
- Saint Anne Hospital
-
Centralia, Washington, Förenta staterna, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Förenta staterna, 98026
- Swedish Cancer Institute-Edmonds
-
Everett, Washington, Förenta staterna, 98201
- Providence Regional Cancer Partnership
-
Issaquah, Washington, Förenta staterna, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Förenta staterna, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Förenta staterna, 98503
- Providence Regional Cancer System-Lacey
-
Longview, Washington, Förenta staterna, 98632
- PeaceHealth Saint John Medical Center
-
Renton, Washington, Förenta staterna, 98055
- Valley Medical Center
-
Seattle, Washington, Förenta staterna, 98105
- Seattle Children's Hospital
-
Seattle, Washington, Förenta staterna, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Förenta staterna, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Förenta staterna, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, Förenta staterna, 98109
- Fred Hutchinson Cancer Center
-
Sedro-Woolley, Washington, Förenta staterna, 98284
- PeaceHealth United General Medical Center
-
Silverdale, Washington, Förenta staterna, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Förenta staterna, 99204
- Providence Sacred Heart Medical Center and Children's Hospital
-
Tacoma, Washington, Förenta staterna, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Förenta staterna, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Förenta staterna, 98431
- Madigan Army Medical Center
-
Vancouver, Washington, Förenta staterna, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Förenta staterna, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Förenta staterna, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
West Virginia
-
Charleston, West Virginia, Förenta staterna, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
-
Wisconsin
-
Appleton, Wisconsin, Förenta staterna, 54911
- ThedaCare Regional Cancer Center
-
Appleton, Wisconsin, Förenta staterna, 54915
- Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
-
Ashland, Wisconsin, Förenta staterna, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Förenta staterna, 54806
- Northwest Wisconsin Cancer Center
-
Brookfield, Wisconsin, Förenta staterna, 53045
- Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
-
Burlington, Wisconsin, Förenta staterna, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chilton, Wisconsin, Förenta staterna, 53014
- Ascension Calumet Hospital-Chilton
-
Eau Claire, Wisconsin, Förenta staterna, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Förenta staterna, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Förenta staterna, 54701
- Mayo Clinic Health System-Eau Claire Clinic
-
Eau Claire, Wisconsin, Förenta staterna, 54703
- Mayo Clinic Health System Eau Claire Hospital-Luther Campus
-
Franklin, Wisconsin, Förenta staterna, 53132
- Ascension Southeast Wisconsin Hospital - Franklin
-
Franklin, Wisconsin, Förenta staterna, 53132
- Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
-
Germantown, Wisconsin, Förenta staterna, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Förenta staterna, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Förenta staterna, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Förenta staterna, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Förenta staterna, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Kenosha, Wisconsin, Förenta staterna, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Förenta staterna, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Förenta staterna, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, Förenta staterna, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Marinette, Wisconsin, Förenta staterna, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Förenta staterna, 54449
- Marshfield Medical Center-Marshfield
-
Mequon, Wisconsin, Förenta staterna, 53097
- Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
-
Milwaukee, Wisconsin, Förenta staterna, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Förenta staterna, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Förenta staterna, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Förenta staterna, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Förenta staterna, 53210
- Ascension Southeast Wisconsin Hospital-Saint Joseph-Milwaukee
-
Milwaukee, Wisconsin, Förenta staterna, 53211
- Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
-
Milwaukee, Wisconsin, Förenta staterna, 53215
- Ascension Saint Francis Hospital-Milwaukee
-
Minocqua, Wisconsin, Förenta staterna, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Förenta staterna, 53149
- ProHealth D N Greenwald Center
-
New Berlin, Wisconsin, Förenta staterna, 53151
- Froedtert and MCW Moorland Reserve Health Center
-
New Richmond, Wisconsin, Förenta staterna, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Förenta staterna, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Förenta staterna, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Förenta staterna, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Oshkosh, Wisconsin, Förenta staterna, 54904
- Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
-
Racine, Wisconsin, Förenta staterna, 53406
- Aurora Cancer Care-Racine
-
Racine, Wisconsin, Förenta staterna, 53405
- Ascension All Saints Hospital-Spring Street-Racine
-
Rhinelander, Wisconsin, Förenta staterna, 54501
- Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
-
Rice Lake, Wisconsin, Förenta staterna, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Förenta staterna, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Förenta staterna, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Stevens Point, Wisconsin, Förenta staterna, 54481
- Aspirus Cancer Care - Stevens Point
-
Sturgeon Bay, Wisconsin, Förenta staterna, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Förenta staterna, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Förenta staterna, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Förenta staterna, 53188
- UW Cancer Center at ProHealth Care
-
Wauwatosa, Wisconsin, Förenta staterna, 53226
- Aurora Cancer Care-Milwaukee West
-
Wauwatosa, Wisconsin, Förenta staterna, 53226
- Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
-
West Allis, Wisconsin, Förenta staterna, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Förenta staterna, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Förenta staterna, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Sheridan, Wyoming, Förenta staterna, 82801
- Welch Cancer Center
-
-
-
-
-
Québec, Kanada, G1V 4G2
- CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
-
-
British Columbia
-
Vancouver, British Columbia, Kanada, V5Z 4E6
- BCCA-Vancouver Cancer Centre
-
Victoria, British Columbia, Kanada, V8R 6V5
- BCCA-Vancouver Island Cancer Centre
-
-
New Brunswick
-
Saint John, New Brunswick, Kanada, E2L 4L2
- Atlantic Health Sciences Corporation-Saint John Regional Hospital
-
-
Nova Scotia
-
Halifax, Nova Scotia, Kanada, B3H 2Y9
- QEII Health Sciences Centre/Nova Scotia Health Authority
-
-
Ontario
-
Brampton, Ontario, Kanada, L6R 3J7
- William Osler Health System-Brampton Civic Hospital
-
Kingston, Ontario, Kanada, K7L 2V7
- Kingston Health Sciences Centre
-
Ottawa, Ontario, Kanada, K1H 8L6
- Ottawa Hospital and Cancer Center-General Campus
-
Toronto, Ontario, Kanada, M5G 2M9
- University Health Network-Princess Margaret Hospital
-
Toronto, Ontario, Kanada, M5G 1X8
- Hospital for Sick Children
-
-
Quebec
-
Montreal, Quebec, Kanada, H3H 1P3
- The Montreal Children's Hospital of the MUHC
-
Montreal, Quebec, Kanada, H3H 2R9
- The Research Institute of the McGill University Health Centre (MUHC)
-
Montreal, Quebec, Kanada, H3T 1C5
- Centre Hospitalier Universitaire Sainte-Justine
-
Québec, Quebec, Kanada, G1J 1Z4
- CHA Hopital L'Enfant-Jesus
-
-
Saskatchewan
-
Regina, Saskatchewan, Kanada, S4T 7T1
- Allan Blair Cancer Centre
-
-
-
-
-
Caguas, Puerto Rico, 00726
- HIMA San Pablo Oncologic Hospital
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San Juan, Puerto Rico, 00926
- University Pediatric Hospital
-
-
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
12 år och äldre (Barn, Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Allt
Beskrivning
Inclusion Criteria:
-
All patients must have histologically confirmed newly diagnosed, previously untreated stage III or IV classical Hodgkin lymphoma (nodular sclerosing, mixed cellularity, lymphocyte-rich, or lymphocyte-depleted, or not otherwise specified [NOS]). Nodular lymphocyte predominant Hodgkin lymphoma is not eligible.
-
Patients must have bidimensionally measurable disease (at least one lesion with longest diameter >= 1.5 cm) documented on the Lymphoma Baseline Tumor Assessment Form in Rave.
-
Patients must have a whole body or limited whole body PET-CT scan performed within 42 days prior to registration. (A contrast-enhanced [diagnostic] CT, MRI or MR-PET is acceptable in event that PET-CT is contra-indicated, however if it is later possible to administer a PET-CT, then PET-CT is strongly preferred for the interim scan (after cycle 2) (if performed) and the EOT assessment. Otherwise, if PET-CT is not subsequently possible, then the same modality as baseline must be used throughout the trial.) NOTE: All images from PET-CT, CT, MRI or MR-PET scans performed as standard of care to assess disease (within 42 days prior to registration) must be submitted and associated radiology reports must be submitted.
-
Patients must be >= 12 years of age.
-
Patients must not have received any prior chemotherapy, radiation, or antibody-based treatment for classical Hodgkin lymphoma. Steroid pre-treatment is permitted.
-
Patients must not have had prior solid organ transplant.
-
Patients must not have had prior allogeneic stem cell transplantation.
-
Patients must not have received a live vaccine within 30 days prior to planned day 1 of protocol therapy (e.g. measles, mumps, rubella, varicella, yellow fever, rabies, Bacillus Calmette-Guerin [BCG], oral polio vaccine, and oral typhoid).
-
At registration, investigator must declare intent-to-treat with residual PET radiation therapy (residual PET RT- RPRT) to be administered after patient completes 6 cycles of therapy if, after end of treatment, the patient meets criteria specified for receiving RT). Patients will be stratified by investigator's intent-to-treat with residual PET RT.
- All pediatric patients (< 18 years of age) will be considered intent-to-treat with Residual PET RT at time of registration.
-
Patients must have a performance status corresponding to Zubrod scores of 0, 1 or 2. Use Lansky for patients =< 17 years of age. *The conversion of the Lansky to Eastern Cooperative Oncology Group (ECOG) scales is intended for National Cancer Institute (NCI) reporting purposes only.
-
Adults (age 18 or older): Creatinine clearance >= 30 mL/min, as estimated by the Cockcroft and Gault formula. The creatinine value used in the calculation must have been obtained within 28 days prior to registration. Estimated creatinine clearance is based on actual body weight.
Pediatric Patients (age 12-17), the following must have been obtained within 14 days prior to registration:
-
Measured or calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2, or
-
Serum creatinine =< 1.5 x institutional upper limit of normal (IULN), or a serum creatinine (SCr) based on age/gender as follows:
-
Age < 13 maximum serum creatinine: Male 1.2 mg/dL; Female 1.2 mg/dL
-
Age 13 to < 16 maximum serum creatinine: Male 1.5 mg/dL; Female 1.4 mg/dL
-
Age 16-17 maximum serum creatinine: Male 1.7 mg/dL; Female 1.4 mg/dL
- Total bilirubin =< 2 x IULN (must be documented within 28 days prior to registration for adults [age 18 or older]; must be documented within 14 days prior to registration for pediatric patients [age 12-17]).
-
-
Unless due to Gilbert's disease, lymphomatous involvement of liver or vanishing bile duct syndrome
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x IULN (must be documented within 28 days prior to registration for adults [age 18 or older]; must be documented within 14 days prior to registration for pediatric patients [age 12-17]).
-
Unless due to Gilbert's disease, lymphomatous involvement of liver or vanishing bile duct syndrome
- Patients must have an echocardiogram (ECHO), multigated acquisition (MUGA), or functional cardiac imaging scan with a left ventricular ejection (LVEF) fraction >= 50% or a shortening fraction of >= 27%. For all patients, the ECHO, MUGA, or functional cardiac imaging scan must be performed within 42 days prior to registration.
- Patients with known human immunodeficiency virus (HIV) infection must be receiving anti-retroviral therapy and have an undetectable or unquantifiable viral load at their most recent viral load test within 6 months prior to registration.
- Patients must not have known active hepatitis B (HBV) or hepatitis C virus (HCV) at date of registration. Patients with previously treated HBV or HCV that have an undetectable viral load within 6 months prior to registration and no residual hepatic impairment are eligible.
- Patients must not have any known central nervous system lymphoma.
- Patients must not have a history of or active interstitial pneumonitis or interstitial lung disease.
- Patients must not have had a diagnosis of inherited or acquired immunodeficiency.
- Patients must not have any known uncontrolled intercurrent illness including, but not limited to symptomatic congestive heart failure, unstable angina pectoris, hemodynamically unstable cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
- Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days prior to registration. Inhaled or topical steroids, and adrenal replacement doses > 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease. Steroid use for the control of Hodgkin lymphoma symptoms is allowable, but must be discontinued prior to cycle 1, day 1.
- Patients with peripheral neuropathy must have < grade 2 at date of registration.
- Patients must not have active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, immunosuppressive drugs, or corticosteroids with doses higher than prednisone 10 mg or equivalent). Autoimmune diseases include but are not limited to autoimmune hepatitis, inflammatory bowel disease (including ulcerative colitis and Crohn's disease), as well as symptomatic disease (e.g.: rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, autoimmune vasculitis [e.g., Wegener's granulomatosis]); central nervous system (CNS) or motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and myasthenia gravis, multiple sclerosis or glomerulonephritis). Vitiligo, alopecia, hypothyroidism on stable doses of thyroid replacement therapy, psoriasis not requiring systemic therapy within the past 2 years are permitted.
- No second prior malignancy is allowed except for adequately treated basal (or squamous cell) skin cancer, any in situ cancer or other cancer for which the patient has been disease free for two years.
- Females of childbearing potential must not be pregnant or nursing, and have a negative pregnancy test within 28 days prior to registration. Women/men of reproductive potential must have agreed to use an effective contraceptive method while receiving study drug and for women until 6 months after receiving the last dose of study drug or, for men, until 7 months after receiving the last dose of study drug. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures.
- Patients must have one formalin-fixed paraffin embedded (FFPE) diagnostic tumor block or at least 1 diagnostic, 4-5 micron, hematoxylin and eosin (H&E) slide collected prior to registration and available for submission.
- Patients must be offered participation in banking for planned translational medicine and future research. With patient consent, any residuals from the mandatory tissue submission will also be banked for future research.
- Patients who can complete Patient-Reported Outcome instruments in English, Spanish, or French must complete the PROMIS Fatigue, the FACT/GOG-Ntx, and the PROMIS Global prior to registration. Patients who do not complete PRO instruments prior to registration but are otherwise eligible will remain eligible for the primary analysis and other secondary analyses.
- Patients who can complete Patient-Reported Outcome instruments in English, Spanish, or French must also agree to complete the PROMIS Fatigue, the FACT/GOG-Ntx, the PROMIS Global, and the PRO-CTCAE (or Pediatric [Ped] PRO-CTCAE) at the scheduled on-study assessment timepoints.
- Patients must be informed of the investigational nature of this study and all patients and/or their parents or legal guardians (for patients < 18 years of age) must sign and give informed consent and assent (where appropriate) in accordance with institutional and federal guidelines. For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board Initiative (CIRB) regulations.
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Note: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Experimentell: Arm I (chemotherapy, nivolumab, radiation)
Patients receive doxorubicin hydrochloride IV, vinblastine sulfate IV, dacarbazine IV, and nivolumab IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim SC on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician. Patients also undergo peripheral blood specimen collection and CT, PET/CT and MRI on study. |
Ancillary studies
Andra namn:
Given IV
Andra namn:
Undergo MRI
Andra namn:
Ancillary studies Given IV
Andra namn:
Given SC or IV
Andra namn:
Given SC
Andra namn:
Undergo PET/CT scan
Andra namn:
Undergo peripheral blood collection
Andra namn:
Undergo PET/CT or CT scan
Andra namn:
Given IV
Andra namn:
Receive radiation therapy
Andra namn:
Given IV
Andra namn:
|
|
Experimentell: Arm II (chemotherapy, brentuximab vedotin, radiation)
Patients receive doxorubicin hydrochloride IV, vinblastine sulfate IV, dacarbazine IV, and brentuximab vedotin IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim SC on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician. Patients also undergo peripheral blood specimen collection and CT, PET/CT and MRI on study. |
Ancillary studies
Andra namn:
Given IV
Andra namn:
Undergo MRI
Andra namn:
Ancillary studies Given IV
Andra namn:
Given SC or IV
Andra namn:
Given SC
Andra namn:
Undergo PET/CT scan
Andra namn:
Undergo peripheral blood collection
Andra namn:
Undergo PET/CT or CT scan
Andra namn:
Given IV
Andra namn:
Receive radiation therapy
Andra namn:
Given IV
Andra namn:
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Progression Free Survival (PFS)
Tidsram: From date of registration to date of first observation of progressive disease, or death due to any cause, assessed at 2 years
|
Will be reported as the number of participants who have experienced death or progression, measured at two years. Progression will be measured according to the 2014 Lugano classification. Will test the null hypothesis (HR=1) for PFS using stratified log-rank test with a one-sided alpha of 0.021. The analysis will be based on modified intent-to-treat and will include all eligible patients as randomized regardless of treatment received. The one-sided alpha of .021 will control of the overall type-one error of the study (including the 2 interim superiority analyses) to be less than .025. |
From date of registration to date of first observation of progressive disease, or death due to any cause, assessed at 2 years
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Overall Survival
Tidsram: From date of registration to two years or death.
|
Will be reported as the count of participants who have died, measured at two years. Stratified log-rank test at two-sided alpha level of .05. |
From date of registration to two years or death.
|
|
Event-free Survival (EFS)
Tidsram: From date of registration to date of first occurrence of EFS event, assessed at 2 years
|
Will be reported as count of participants who have experienced an EFS event or death at two years. EFS Events are defined as:
|
From date of registration to date of first occurrence of EFS event, assessed at 2 years
|
|
Number of Participants With of Adverse Events
Tidsram: Up to 2 years
|
Only adverse events that are possibly, probably or definitely related to study drug are reported. |
Up to 2 years
|
|
Metabolic Complete Response Rate
Tidsram: 4-8 weeks after last dose of study drug
|
This outcome measure will be reported by 11/5/2025. |
4-8 weeks after last dose of study drug
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: Alex F Herrera, SWOG Cancer Research Network
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Allmänna publikationer
- Castellino SM, Giulino-Roth L, Harker-Murray P, Kahn JM, Forlenza C, Cho S, Hoppe B, Parsons SK, Kelly KM; COG Hodgkin Lymphoma Committee. Children's Oncology Group's 2023 blueprint for research: Hodgkin lymphoma. Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30580. doi: 10.1002/pbc.30580. Epub 2023 Jul 28.
- Herrera AF, LeBlanc M, Castellino SM, Li H, Rutherford SC, Evens AM, Davison K, Punnett A, Parsons SK, Ahmed S, Casulo C, Bartlett NL, Tuscano JM, Mei MG, Hess BT, Jacobs R, Saeed H, Torka P, Hu B, Moskowitz C, Kaur S, Goyal G, Forlenza C, Doan A, Lamble A, Kumar P, Chowdhury S, Brinker B, Sharma N, Singh A, Blum KA, Perry AM, Kovach AE, Hodgson D, Constine LS, Shields LK, Prica A, Dillon H, Little RF, Shipp MA, Crump M, Kahl B, Leonard JP, Smith SM, Song JY, Kelly KM, Friedberg JW. Nivolumab+AVD in Advanced-Stage Classic Hodgkin's Lymphoma. N Engl J Med. 2024 Oct 17;391(15):1379-1389. doi: 10.1056/NEJMoa2405888.
- Castellino SM, Li H, Herrera AF, LeBlanc M, Parsons SK, Unger JM, Punnett A, Hodgson D, Keller FG, Drachtman RA, Lamble A, Forlenza CJ, Doan A, Rutherford SC, Evens AM, Little RF, Smith MA, Hoppe BS, Song JY, Smith SM, Friedberg JW, Kelly KM. Three-Year Follow-Up of Nivolumab-AVD Versus Brentuximab Vedotin-AVD in Adolescents With Advanced-Stage Classic Hodgkin Lymphoma on S1826. J Clin Oncol. 2026 Feb 20;44(6):449-454. doi: 10.1200/JCO-25-00203. Epub 2026 Jan 9.
- McKenna M, Ryu Tiger YK, Rutherford SC, Evens AM. The Management of older patients with Hodgkin lymphoma: implications of S1826. Semin Hematol. 2024 Aug;61(4):236-244. doi: 10.1053/j.seminhematol.2024.05.004. Epub 2024 Jun 4.
- Ahmed S, Li H, Herrera AF, Perry AM, Kovach AE, Rutherford SC, Davison K, Castellino SM, Evens AM, Kahl BS, Bartlett N, Leonard JP, Shipp MA, Smith SM, Kelly KM, LeBlanc ML, Friedberg JW, Song JYY. Impact of EBV Status and Histology on Patient Outcomes with Nivolumab-AVD vs BV-AVD in Advanced Classic Hodgkin Lymphoma (S1826). Blood Adv. 2026 Jul 29:bloodadvances.2026021402. doi: 10.1182/bloodadvances.2026021402. Online ahead of print.
- Goyal G, Lurain K, Lopez G, Rutherford SC, Castellino S, Davison K, Evens A, Smith SM, Kelly K, LeBlanc M, Song JY, Odeny T, Ratner L, Friedberg JW, Herrera AF. Nivolumab + Doxorubicin, Vinblastine, and Dacarbazine in HIV-Associated Advanced-Stage Classic Hodgkin Lymphoma. JCO Oncol Adv. 2026 Jan;3(1):e2500143. doi: 10.1200/oa-25-00143. Epub 2026 Feb 26.
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
29 augusti 2019
Primärt slutförande (Faktisk)
31 mars 2024
Avslutad studie (Beräknad)
28 mars 2027
Studieregistreringsdatum
Först inskickad
8 april 2019
Först inskickad som uppfyllde QC-kriterierna
8 april 2019
Första postat (Faktisk)
9 april 2019
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
22 oktober 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
21 oktober 2026
Senast verifierad
1 september 2026
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
- Neoplasmer
- Immunsystemets sjukdomar
- Neoplasmer efter histologisk typ
- Lymfatiska sjukdomar
- Lymfoproliferativa störningar
- Immunproliferativa störningar
- Lymfom
- Hemiska och lymfsjukdomar
- Hodgkins sjukdom
- Peptider
- Aminosyror, peptider och proteiner
- Oligopeptider
- Proteiner
- Organiska kemikalier
- Heterocykliska föreningar, 1-ring
- Heterocykliska föreningar
- Heterocykliska föreningar, 2-ring
- Heterocykliska föreningar, smältring
- Undersökningstekniker
- Terapeutik
- Kliniska laboratorietekniker
- Diagnostiska tekniker och procedurer
- Diagnos
- Azoler
- Kolväten
- Kolväten, cykliska
- Biologiska faktorer
- Kolhydrater
- Fysiska fenomen
- Alkaloider
- Polycykliska aromatiska kolväten
- Kolväten, aromatisk
- Polycykliska föreningar
- Glykosider
- Triazenes
- Imidazoler
- Förenad
- Antikroppar, monoklonal, humaniserad
- Antikroppar, monoklonal
- Antikroppar
- Immunglobuliner
- Immunoproteiner
- Blodproteiner
- Serumglobuliner
- Globuliner
- Kemitekniker, analytiska
- Spektrumanalys
- Intercellulära signalpeptider och proteiner
- Vinca alkaloider
- Secologanin tryptaminalkaloider
- Indolalkaloider
- Indolizidiner
- Indoliziner
- Anthracykliner
- Naftakener
- Aminoglykosider
- Glykoprotiner
- Glykokonjugat
- Daunorubicin
- Kolonistimulerande faktorer
- Hematopoietiska celltillväxtfaktorer
- Cytokiner
- Nivolumab
- Brentuximab Vedotin
- Doxorubicin
- Dakarbazin
- Vinblastin
- Strålbehandling
- Strålning
- Provhantering
- Magnetresonansspektroskopi
- Granulocytkolonistimulerande faktor
- Filgrastim
- pegfilgrastim
- PEGylerad granulocytkolonistimulerande faktor
Andra studie-ID-nummer
- NCI-2019-01960
- NCI-2019-01960 (Registeridentifierare: CTRP (Clinical Trial Reporting Program))
- S1826 (Annan identifierare: CTEP)
- U10CA180888 (U.S.S. NIH-anslag/kontrakt)
- S1826 (Annan identifierare: SWOG)
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
JA
IPD-planbeskrivning
NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page
Läkemedels- och apparatinformation, studiedokument
Studerar en amerikansk FDA-reglerad läkemedelsprodukt
Ja
Studerar en amerikansk FDA-reglerad produktprodukt
Nej
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