Denne siden ble automatisk oversatt og nøyaktigheten av oversettelsen er ikke garantert. Vennligst referer til engelsk versjon for en kildetekst.

En studie for å evaluere effektiviteten og sikkerheten til Sacituzumab Tirumotecan (MK-2870) behandling kontra omsorgsstandard hos deltakere med platinasensitiv tilbakevendende eggstokkreft (MK-2870-022/troffuse-022/Engot-OV84/GOG-3103)

1. september 2026 oppdatert av: Merck Sharp & Dohme LLC

En fase 3, randomisert, open-etikett, multisenterstudie for å evaluere effektiviteten og sikkerheten til sacituzumab tirumotekan vedlikeholdsbehandling med eller uten bevacizumab versus standard for omsorg etter andre linjet platinabasert dobbeltkjemoterapi hos deltakere med platinasensitiv tilbakevendende eggstokkreft ( Trofuse-022/Engot-OV84/GOG-3103)

Hovedmålene med denne studien er å lære om sikkerheten til sacituzumab tirumotecan med bevacizumab og om folk tåler det; Og hvis folk som tar Sacituzumab Tirumotecan med eller uten bevacizumab, lever lenger uten at kreften blir verre enn de som får standard for omsorgsbehandling.

Studieoversikt

Status

Rekruttering

Forhold

Intervensjon / Behandling

Studietype

Intervensjonell

Registrering (Antatt)

770

Fase

  • Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Studiesteder

  • Argentina
      • CABA, Argentina, C1118AAT
        • Rekruttering
        • Hospital Aleman ( Site 2903)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +541148277000
      • Córdoba, Argentina, 5000
        • Rekruttering
        • Hospital Italiano de Cordoba ( Site 2908)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +543517078224
    • Buenos Aires
      • Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ANZ
        • Rekruttering
        • Instituto Alexander Fleming ( Site 2909)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 5411 3221 8900
      • Mar del Plata, Buenos Aires, Argentina, B7600FZO
        • Rekruttering
        • Instituto de Investigaciones Clinicas Mar del Plata ( Site 2901)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +54 223 496 3224
    • Buenos Aires F.D.
      • Buenos Aires, Buenos Aires F.D., Argentina, C1426AAL
        • Rekruttering
        • Fundación Respirar ( Site 2912)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +5491167281601
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, S2000KZE
        • Rekruttering
        • Instituto de Oncologia de Rosario ( Site 2910)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +543414218909
  • Australia
    • New South Wales
      • Sydney, New South Wales, Australia, 2148
        • Rekruttering
        • Blacktown Hospital ( Site 0211)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +61286705071
    • Queensland
      • Brisbane, Queensland, Australia, 4120
        • Rekruttering
        • Gallipoli Medical Research Ltd ( Site 0214)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +61733947284
    • Victoria
      • East Melbourne, Victoria, Australia, 3002
        • Rekruttering
        • Epworth Freemasons ( Site 0217)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +61385595000
      • Frankston, Victoria, Australia, 3199
        • Rekruttering
        • Frankston Hospital ( Site 0216)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +61409848084
  • Belgia
      • Namur, Belgia, 5000
        • Rekruttering
        • CHU UCL Namur/Site Sainte Elisabeth ( Site 0302)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +32 (0)81 70 28 44
    • Antwerpen
      • Edegem, Antwerpen, Belgia, 2650
        • Rekruttering
        • Antwerp University Hospital ( Site 0304)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: + 32 3 821 47 19
    • Liege
      • Liège, Liege, Belgia, 4000
        • Rekruttering
        • Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman ( Site 0306)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +32 4 323 5332
    • Oost-Vlaanderen
      • Ghent, Oost-Vlaanderen, Belgia, 9000
        • Rekruttering
        • AZ Sint-Lucas ( Site 0305)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +32 9 224 66 20
    • Vlaams-Brabant
      • Leuven, Vlaams-Brabant, Belgia, 3000
        • Rekruttering
        • UZ Leuven ( Site 0301)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +32 16 34 74 19
  • Brasil
      • Rio de Janeiro, Brasil, 20220-410
        • Rekruttering
        • Instituto Nacional de Câncer - INCA ( Site 0422)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +552132072985
      • São Paulo, Brasil, 04014-002
        • Rekruttering
        • IBCC - Núcleo de Pesquisa e Ensino ( Site 0424)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +551134744264
      • São Paulo, Brasil, 01321-001
        • Rekruttering
        • Hospital Paulistano ( Site 0421)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +551130161000
    • Rio Grande do Norte
      • Natal, Rio Grande do Norte, Brasil, 59062-000
        • Rekruttering
        • Liga Norte Riograndense Contra o Cancer ( Site 0423)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +558440095600
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brasil, 90610000
        • Rekruttering
        • Hospital São Lucas da PUCRS ( Site 0425)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +555133203000
    • Santa Catarina
      • Lages, Santa Catarina, Brasil, 88501-001
        • Rekruttering
        • ANIMI - Unidade de Tratamento Oncologico ( Site 0419)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +554933805200
    • São Paulo
      • São José do Rio Preto, São Paulo, Brasil, 15090-000
        • Rekruttering
        • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0413)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +55 17 32015054
  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 5G2
        • Rekruttering
        • Arthur J.E. Child Comprehensive Cancer Centre ( Site 0512)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 5872315594
    • Ontario
      • Greater Sudbury, Ontario, Canada, P3E 5J1
        • Rekruttering
        • Health Sciences North Research Institute ( Site 0517)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 7055237100
      • Mississauga, Ontario, Canada, L5M 2N1
        • Rekruttering
        • Trillium Health Partners - Credit Valley Hospital ( Site 0508)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 905-813-2200
      • Toronto, Ontario, Canada, M5G 2M9
        • Rekruttering
        • Princess Margaret Cancer Centre ( Site 0518)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: (416) 946-4501
    • Quebec
      • Montreal, Quebec, Canada, H4A 3J1
        • Rekruttering
        • McGill University Health Centre ( Site 0502)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 514-934-1934
      • Montreal, Quebec, Canada, H1T 2M4
        • Rekruttering
        • CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 0505)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 514-252-3400
  • Chile
    • Los Lagos Region
      • Port Montt, Los Lagos Region, Chile, 5507642
        • Rekruttering
        • Clinica Puerto Montt ( Site 0615)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 56961687093
    • Region M. de Santiago
      • Santiago, Region M. de Santiago, Chile, 8330032
        • Rekruttering
        • Pontificia Universidad Catolica de Chile ( Site 0611)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 56934331806
      • Santiago, Region M. de Santiago, Chile, 8420383
        • Rekruttering
        • Bradfordhill-Clinical Area ( Site 0610)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 56229490970
      • Santiago, Region M. de Santiago, Chile, 7500921
        • Rekruttering
        • FALP ( Site 0616)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 56224205098
    • Valparaiso
      • Viña del Mar, Valparaiso, Chile, 2520598
        • Rekruttering
        • ONCOCENTRO APYS-ACEREY ( Site 0612)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +56323320860
  • Colombia
    • Bogota D.C.
      • Bogotá, Bogota D.C., Colombia, 110131
        • Rekruttering
        • FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0806)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +576015948650
      • Bogotá, Bogota D.C., Colombia, 111511
        • Rekruttering
        • Instituto Nacional De Cancerologia ( Site 0807)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +573154208007
    • Risaralda Department
      • Pereira, Risaralda Department, Colombia, 660001
        • Rekruttering
        • Oncologos Del Occidente ( Site 0805)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +57 3187715522
  • Danmark
    • Capital Region
      • Copenhagen, Capital Region, Danmark, 2100
        • Rekruttering
        • Rigshospitalet ( Site 0904)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +45 35453545
      • Herlev, Capital Region, Danmark, 2730
        • Rekruttering
        • Herlev Hospital ( Site 0903)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +45 38683868
    • North Denmark
      • Aalborg, North Denmark, Danmark, 9000
        • Rekruttering
        • Aalborg Universitetshospital ( Site 0901)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 97661400
    • Region Syddanmark
      • Vejle, Region Syddanmark, Danmark, 7100
        • Rekruttering
        • Vejle Sygehus ( Site 0902)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 79406088
  • Finland
    • North Ostrobothnia
      • Oulu, North Ostrobothnia, Finland, 90220
        • Rekruttering
        • Oulun yliopistollinen sairaala ( Site 1003)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +358505794505
    • Northern Savonia
      • Kuopio, Northern Savonia, Finland, 70200
        • Rekruttering
        • Kuopion Yliopistollinen Sairaala ( Site 1004)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +358447174617
    • Pirkanmaa
      • Tampere, Pirkanmaa, Finland, 33520
        • Rekruttering
        • Tampereen yliopistollinen sairaala ( Site 1002)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +358407274241
  • Forente stater
    • Alabama
      • Birmingham, Alabama, Forente stater, 35249
        • Rekruttering
        • University of Alabama at Birmingham ( Site 0006)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: (205) 934-7442
    • Alaska
      • Anchorage, Alaska, Forente stater, 99508
        • Rekruttering
        • Alaska Women's Cancer Care ( Site 0096)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 907-562-4673
    • California
      • San Francisco, California, Forente stater, 94158
        • Rekruttering
        • UCSF Medical Center at Mission Bay ( Site 0013)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 415-353-3000
      • Walnut Creek, California, Forente stater, 94598
        • Rekruttering
        • John Muir Health Cancer Center ( Site 0016)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 925-692-5603
    • Connecticut
      • New Haven, Connecticut, Forente stater, 06510
        • Rekruttering
        • Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 0001)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 203-785-5702
    • Florida
      • Miami Beach, Florida, Forente stater, 33140
        • Rekruttering
        • Mount Sinai Braman Comprehensive Cancer Center ( Site 0078)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 305-674-2625
      • Sarasota, Florida, Forente stater, 34239
        • Rekruttering
        • Sarasota Memorial Hospital ( Site 0075)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 941-917-2225
      • West Palm Beach, Florida, Forente stater, 33401
        • Rekruttering
        • Florida Cancer Specialists East ( Site 7000)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 561-366-4100
    • Georgia
      • Atlanta, Georgia, Forente stater, 30322
        • Rekruttering
        • Winship Cancer Institute of Emory University ( Site 0086)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 404-778-1900
      • Augusta, Georgia, Forente stater, 30912
        • Rekruttering
        • Augusta University - Georgia Cancer Center ( Site 0066)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 706-721-6744
    • Indiana
      • Fort Wayne, Indiana, Forente stater, 46845
        • Rekruttering
        • Parkview Research Center at Parkview Regional Medical Center ( Site 0003)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 260-425-6981
    • Louisiana
      • Covington, Louisiana, Forente stater, 70433
        • Rekruttering
        • Women's Cancer Care ( Site 0067)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 985-892-2252
    • Maine
      • Scarborough, Maine, Forente stater, 04074
        • Rekruttering
        • Maine Medical Center Research Institute-MaineHealth/Maine Medical Partners - GynOnc ( Site 0008)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 207-883-0069
    • Minnesota
      • Maplewood, Minnesota, Forente stater, 55109
        • Rekruttering
        • Minnesota Oncology Hematology (MNO) ( Site 8002)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 615-693-2574
    • Mississippi
      • Jackson, Mississippi, Forente stater, 39216
        • Aktiv, ikke rekrutterende
        • St. Dominic's Hospital ( Site 0064)
    • Missouri
      • St Louis, Missouri, Forente stater, 63110
        • Rekruttering
        • Washington University School of Medicine ( Site 0052)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 314-454-6215
    • Nebraska
      • Omaha, Nebraska, Forente stater, 68114
        • Rekruttering
        • Nebraska Methodist Hospital ( Site 0053)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 402-354-8534
    • New Jersey
      • Hackensack, New Jersey, Forente stater, 07601
        • Rekruttering
        • John Theurer Cancer Center at Hackensack University Medical Center ( Site 0081)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 551-996-5855
      • New Brunswick, New Jersey, Forente stater, 08901
        • Rekruttering
        • Rutgers Cancer Institute of New Jersey ( Site 0071)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 732-235-7258
    • New Mexico
      • Albuquerque, New Mexico, Forente stater, 87131
        • Rekruttering
        • University of New Mexico Comprehensive Cancer Center ( Site 0055)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 505-272-4946
    • New York
      • Mineola, New York, Forente stater, 11501
        • Rekruttering
        • NYU Langone Hospital - Long Island ( Site 0015)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 516-663-0333
      • New York, New York, Forente stater, 10016
        • Rekruttering
        • Laura and Isaac Perlmutter Cancer Center ( Site 0076)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 212-731-6000
    • North Carolina
      • Pinehurst, North Carolina, Forente stater, 28374
        • Rekruttering
        • FirstHealth Cancer Center ( Site 0079)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 910-715-8684
    • Ohio
      • Cincinnati, Ohio, Forente stater, 45219
        • Rekruttering
        • University of Cincinnati Medical Center ( Site 0090)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 513-584-1958
      • Columbus, Ohio, Forente stater, 43210
        • Rekruttering
        • The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0054)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 614-293-3300
    • Oklahoma
      • Tulsa, Oklahoma, Forente stater, 74146
        • Rekruttering
        • Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0056)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 918-505-3200
    • Oregon
      • Eugene, Oregon, Forente stater, 97401
        • Rekruttering
        • Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8010)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 541-683-5001
    • Pennsylvania
      • Pittsburgh, Pennsylvania, Forente stater, 15224
        • Rekruttering
        • Allegheny Health Network West Penn Hospital ( Site 0099)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 412-578-5000
    • Rhode Island
      • Providence, Rhode Island, Forente stater, 02905
        • Rekruttering
        • Women & Infants Hospital ( Site 0050)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 401-274-1100
    • Tennessee
      • Nashville, Tennessee, Forente stater, 37232
        • Rekruttering
        • Henry-Joyce Cancer Clinic ( Site 0060)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 615-936-8422
    • Texas
      • Austin, Texas, Forente stater, 78758
        • Rekruttering
        • Texas Oncology - Central/South Texas ( Site 8009)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 512-873-8900
      • Fort Worth, Texas, Forente stater, 76104
        • Rekruttering
        • Texas Oncology - DFW ( Site 8001)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 817-413-1500
      • San Antonio, Texas, Forente stater, 78240
        • Rekruttering
        • Texas Oncology - San Antonio ( Site 8005)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 210-595-5300
      • San Antonio, Texas, Forente stater, 78229
        • Rekruttering
        • University Of Texas Health Science Center -San Antonio ( Site 0095)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 210-567-7000
      • Webster, Texas, Forente stater, 77598
        • Rekruttering
        • Texas Oncology - Gulf Coast ( Site 8003)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 281-332-7505
    • Virginia
      • Fairfax, Virginia, Forente stater, 22031
        • Rekruttering
        • Virginia Cancer Specialists (VCS) ( Site 8011)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: (571) 350-8400
  • Frankrike
      • Paris, Frankrike, 75020
        • Rekruttering
        • Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 1102)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33 1 44 74 11 53
    • Ain
      • Lille, Ain, Frankrike, 59020
        • Rekruttering
        • Centre Oscar Lambret ( Site 1104)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33320295959
    • Aquitaine
      • Bordeaux, Aquitaine, Frankrike, 33076
        • Rekruttering
        • Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1101)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33556333333
    • Auvergne-Rhône-Alpes
      • Pierre-Bénite, Auvergne-Rhône-Alpes, Frankrike, 69310
        • Rekruttering
        • Centre Hopitalier Lyon Sud ( Site 1110)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33478864318
    • Calvados
      • Caen, Calvados, Frankrike, 14076
        • Rekruttering
        • Centre Francois Baclesse ( Site 1108)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33231459700
    • Cotes-d Armor
      • Plérin, Cotes-d Armor, Frankrike, 22190
        • Rekruttering
        • Hôpital Privé Des Côtes d'Armor ( Site 1106)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33257240243
    • Haute-Garonne
      • Toulouse, Haute-Garonne, Frankrike, 31059
        • Rekruttering
        • LBM ONCOPOLE CLAUDIUS REGAUD ( Site 1109)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33531155101
    • Indre-et-Loire
      • Chambray-lès-Tours, Indre-et-Loire, Frankrike, 37170
        • Rekruttering
        • Pôle Santé Léonard de Vinci ( Site 1112)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33247602060
    • Paris
      • Paris, Paris, Frankrike, 75014
        • Rekruttering
        • Groupe Hospitalier Broca Cochin Hotel Dieu ( Site 1111)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33158411439
    • Pays de la Loire Region
      • Saint-Herblain, Pays de la Loire Region, Frankrike, 44805
        • Rekruttering
        • Institut De Cancerologie De L Ouest ( Site 1107)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33 2 40 67 99 00
    • Vaucluse
      • Avignon, Vaucluse, Frankrike, 84918
        • Rekruttering
        • Sainte Catherine Institut du Cancer Avignon Provence ( Site 1105)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +33490276161
  • Hellas
    • Attica
      • Athens, Attica, Hellas, 115 28
        • Rekruttering
        • Aretaieio Hospital ( Site 0701)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +302107286444
      • Chaïdári, Attica, Hellas, 12462
        • Rekruttering
        • ATTIKON GENERAL UNIVERSITY HOSPITAL-Oncology ( Site 0702)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +302105831643
  • Irland
      • Dublin, Irland, DO8 NHY1
        • Rekruttering
        • St James Hospital ( Site 1301)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +35314103747
  • Israel
      • Hadera, Israel, 3810101
        • Rekruttering
        • Hillel Yaffe Medical Center ( Site 1404)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +972544512396
      • Haifa, Israel, 3109601
        • Rekruttering
        • Rambam Health Care Campus ( Site 1402)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +97247772688
      • Jerusalem, Israel, 9103102
        • Rekruttering
        • Shaare Zedek Medical Center ( Site 1405)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +97226555424
      • Kfar Saba, Israel, 4428164
        • Rekruttering
        • Meir Medical Center. ( Site 1403)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 972-9-7471575
      • Ramat Gan, Israel, 5265601
        • Rekruttering
        • Sheba Medical Center ( Site 1401)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 972-3-5303157
  • Italia
      • Bari, Italia, 70124
        • Rekruttering
        • Instituto Tumori Giovanni Paolo II ( Site 1505)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +390805555355
      • Brescia, Italia, 25124
        • Rekruttering
        • Istituto Ospedaliero,Fondazione Poliambulanza ( Site 1511)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +390303518503
      • Milan, Italia, 20141
        • Rekruttering
        • Istituto Europeo di Oncologia ( Site 1506)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +390257482540
      • Milan, Italia, 20159
        • Rekruttering
        • Humanitas San Pio X Hospital ( Site 1503)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +390269516354
      • Naples, Italia, 80131
        • Rekruttering
        • Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1501)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +390815903637
      • Padova, Italia, 35128
        • Rekruttering
        • Istituto Oncologico Veneto IRCCS ( Site 1508)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +390498215729
      • Roma, Italia, 00168
        • Rekruttering
        • Fondazione Policlinico Universitario Agostino Gemelli ( Site 1502)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +390630157004
      • Torino, Italia, 10128
        • Rekruttering
        • Ospedale Mauriziano ( Site 1509)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +39 0115082277
    • Friuli Venezia Giulia
      • Aviano, Friuli Venezia Giulia, Italia, 33081
        • Rekruttering
        • CRO-IRCCS ( Site 1510)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +390434659474
    • Milano
      • Milan, Milano, Italia, 20133
        • Rekruttering
        • Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1507)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 39 0223903479
    • Tuscany
      • Pisa, Tuscany, Italia, 56126
        • Rekruttering
        • Azienda Ospedaliero Universitaria Pisana ( Site 1504)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +39050992371
  • Japan
      • Fukuoka, Japan, 811-1395
        • Rekruttering
        • National Hospital Organization Kyushu Cancer Center ( Site 1628)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-92-541-3231
      • Kagoshima, Japan, 890-8760
        • Rekruttering
        • Kagoshima City Hospital ( Site 1638)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-99-230-7000
      • Niigata, Japan, 951-8566
        • Rekruttering
        • Niigata Cancer Center Hospital ( Site 1633)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-25-266-5111
      • Osaka, Japan, 541-8567
        • Rekruttering
        • Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 1629)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-6-6945-1181
    • Aichi-ken
      • Nagoya, Aichi-ken, Japan, 464-8681
        • Rekruttering
        • Aichi Cancer Center ( Site 1626)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-52-762-6111
    • Chiba
      • Kashiwa, Chiba, Japan, 277-8577
        • Rekruttering
        • National Cancer Center Hospital East ( Site 1641)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-4-7133-1111
    • Ehime
      • Matsuyama, Ehime, Japan, 791-0280
        • Rekruttering
        • National Hospital Organization Shikoku Cancer Center ( Site 1631)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-89-999-1111
      • Tōon, Ehime, Japan, 791-0295
        • Rekruttering
        • Ehime University Hospital ( Site 1637)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-89-964-5111
    • Fukuoka
      • Kurume, Fukuoka, Japan, 830-0011
        • Rekruttering
        • Kurume University Hospital ( Site 1640)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-942-35-3311
    • Gunma
      • Ōta, Gunma, Japan, 373-8550
        • Rekruttering
        • Gunma Prefectural Cancer Center ( Site 1630)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-276-38-0771
    • Hokkaido
      • Sapporo, Hokkaido, Japan, 060-8648
        • Rekruttering
        • Hokkaido University Hospital ( Site 1634)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-11-716-1161
    • Iwate
      • Shiwa-gun, Iwate, Japan, 028-3695
        • Rekruttering
        • Iwate Medical University Hospital ( Site 1635)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-19-613-7111
    • Saitama
      • Hidaka, Saitama, Japan, 350-1298
        • Rekruttering
        • Saitama Medical University International Medical Center ( Site 1632)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-42-984-4111
    • Shizuoka
      • Sunto-gun,, Shizuoka, Japan, 411-8777
        • Rekruttering
        • Shizuoka Cancer Center ( Site 1643)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-55-989-5222
    • Tokyo
      • Koto, Tokyo, Japan, 135-8550
        • Rekruttering
        • Cancer Institute Hospital of JFCR ( Site 1639)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-3-3520-0111
      • Shinjyuku, Tokyo, Japan, 160-8582
        • Rekruttering
        • Keio University Hospital ( Site 1636)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +81-3-3353-1211
  • Mexico
      • Aguascalientes, Mexico, 20124
        • Rekruttering
        • Centro de Investigación Oncológica Galerías SC ( Site 1720)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +525527280926
      • Cuauhtémoc, Mexico, 6100
        • Rekruttering
        • Cryptex Investigación Clínica S.A. de C.V. ( Site 1715)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +525555743589
      • Mexico City, Mexico, 04700
        • Rekruttering
        • COI Centro Oncologico Internacional S.A.P.I. de C.V. ( Site 1717)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +525554248970x4016
      • Oaxaca City, Mexico, 68020
        • Rekruttering
        • Centro de Investigacion Clinica de Oaxaca ( Site 1714)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +529516035559
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44630
        • Rekruttering
        • CIO - Centro de Inmuno-Oncología de Occidente ( Site 1719)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +523313587270
    • Mexico City
      • Mexico City, Mexico City, Mexico, 11819
        • Rekruttering
        • Higiea Oncologia ( Site 1713)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +525554137773
    • Nuevo León
      • Monterrey, Nuevo León, Mexico, 64710
        • Rekruttering
        • I CAN ONCOLOGY CENTER S.A. DE C.V. ( Site 1716)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +528125558165
      • Monterrey, Nuevo León, Mexico, 66220
        • Rekruttering
        • Servicios de Oncología Médica Integral - Monterrey ( Site 1712)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +5218118213989
      • Monterrey, Nuevo León, Mexico, 64460
        • Rekruttering
        • Laboratorio de Patología Clínica del Hospital Universitario "Dr. José Eleuterio González" ( Site 1711)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +528115443345
  • Peru
      • Lima, Peru, 15036
        • Rekruttering
        • IPOR Instituto Peruano de Oncología & Radioterapia ( Site 3604)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +51 951 881 870
      • Lima, Peru, 15072
        • Rekruttering
        • Clínica San Felipe ( Site 3603)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +5112190000 Ext 8327
      • Lima, Peru, 15038
        • Rekruttering
        • INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 3601)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +51 940 238 282
      • Lima, Peru, 15001
        • Rekruttering
        • Hospital Guillermo Almenara Irigoyen ( Site 3608)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +51999903343
      • Lima, Peru, 15102
        • Rekruttering
        • Hospital Cayetano Heredia ( Site 3607)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +51 922 371 048
    • Piura
      • Castilla, Piura, Peru, 20001
        • Rekruttering
        • Unidad de Investigacion Oncologia Clínica Piura ( Site 3606)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +51969618109
  • Polen
    • Greater Poland Voivodeship
      • Poznan, Greater Poland Voivodeship, Polen, 61-848
        • Rekruttering
        • Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2106)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +48618549049
    • Masovian Voivodeship
      • Warsaw, Masovian Voivodeship, Polen, 02-781
        • Rekruttering
        • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Site 2101)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 0048225462295
    • Podlaskie Voivodeship
      • Bialystok, Podlaskie Voivodeship, Polen, 15-027
        • Rekruttering
        • Bialostockie Centrum Onkologii ( Site 2104)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 0048856646728
    • West Pomeranian Voivodeship
      • Szczecin, West Pomeranian Voivodeship, Polen, 70-111
        • Rekruttering
        • Samodzielny Publiczny Szpital Kliniczny Nr 2 PUM w Szczecinie ( Site 2103)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +48914661332
    • Świętokrzyskie Voivodeship
      • Kielce, Świętokrzyskie Voivodeship, Polen, 25-734
        • Rekruttering
        • Swietokrzyskie Centrum Onkologii. ( Site 2105)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 0048413674128
  • Portugal
      • Lisbon, Portugal, 1500-650
        • Rekruttering
        • Hospital da Luz ( Site 3802)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +351217104400
      • Porto, Portugal, 4200-072
        • Rekruttering
        • Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 3801)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +351225084000
  • Romania
      • Bucharest, Romania, 011132
        • Rekruttering
        • Spitalul Clinic Filantropia ( Site 2213)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +40213188930
      • Bucharest, Romania, 013975
        • Rekruttering
        • SC MNT Healthcare Europe SRL ( Site 2218)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +40722927377
    • Cluj
      • Cluj-Napoca, Cluj, Romania, 400015
        • Rekruttering
        • Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2215)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +40264598362
    • Dolj
      • Craiova, Dolj, Romania, 200746
        • Rekruttering
        • S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2211)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +40731604432
    • Timiș County
      • Timișoara, Timiș County, Romania, 300239
        • Rekruttering
        • Cabinet Medical Oncomed ( Site 2217)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +40256495403
  • Spania
      • Barcelona, Spania, 08035
        • Rekruttering
        • Hospital Vall D Hebron ( Site 2403)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +34932746085
      • Barcelona, Spania, 08907
        • Rekruttering
        • ICO L Hospitalet ( Site 2408)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +34932607744
      • Barcelona, Spania, 08036
        • Rekruttering
        • Hospital Clinic I Provincial de Barcelona ( Site 2409)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 34932275402
      • Córdoba, Spania, 14004
        • Rekruttering
        • Hospital Universitario Reina Sofia ( Site 2406)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +34957011464
      • Madrid, Spania, 28034
        • Rekruttering
        • Hospital Ramon y Cajal ( Site 2405)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +3491336 82 63
      • Madrid, Spania, 28041
        • Rekruttering
        • Hospital Universitario 12 de Octubre ( Site 2411)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +34913908626
      • Madrid, Spania, 28040
        • Rekruttering
        • Hospital Clinico San Carlos... ( Site 2410)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 34 913303000 x484811
      • Madrid, Spania, 28046
        • Rekruttering
        • Hospital Universitario La Paz ( Site 2404)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +34 679927508
    • Gerona
      • Girona, Gerona, Spania, 17007
        • Rekruttering
        • Institut Català d'Oncologia (ICO) - Girona ( Site 2402)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +34972225828
    • Madrid, Comunidad de
      • Madrid, Madrid, Comunidad de, Spania, 28027
        • Rekruttering
        • Clinica Universidad de Navarra ( Site 2407)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +34913531920
      • Madrid, Madrid, Comunidad de, Spania, 28007
        • Rekruttering
        • Hospital General Gregorio Maranon de Madrid ( Site 2412)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +34915860860
    • Valenciana, Comunitat
      • Valencia, Valenciana, Comunitat, Spania, 46010
        • Rekruttering
        • Hosp Clinico Universitario de Valencia ( Site 2401)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 34 961973500
  • Storbritannia
      • Birmingham, Storbritannia, B15 2TH
        • Rekruttering
        • Queen Elizabeth Hospital Birmingham ( Site 2804)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 0121 371 8766
      • Leicester, Storbritannia, LE1 5WW
        • Rekruttering
        • Leicester Royal Infirmary ( Site 2808)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 0300 303 1573
      • Liverpool, Storbritannia, L7 8YA
        • Rekruttering
        • Clatterbridge Cancer Centre - Liverpool ( Site 2805)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 0151 556 5000
    • Cambridgeshire
      • Cambridge, Cambridgeshire, Storbritannia, CB2 2QQ
        • Rekruttering
        • Cambridge University Hospital ( Site 2803)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 01223 216083
    • Edinburgh, City of
      • Edinburgh, Edinburgh, City of, Storbritannia, EH4 2XU
        • Rekruttering
        • Western General Hospital ( Site 2806)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +441315371000
    • Lancashire
      • Preston, Lancashire, Storbritannia, PR2 9HT
        • Rekruttering
        • Royal Preston Hospital ( Site 2807)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 01772 524656
    • London, City of
      • London, London, City of, Storbritannia, SW3 6JJ
        • Rekruttering
        • ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 2801)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 02089156899
      • Sutton, London, City of, Storbritannia, SM2 5PT
        • Rekruttering
        • Royal Marsden Hospital (Sutton) ( Site 2802)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 02089156899
  • Sør -Korea
      • Seoul, Sør -Korea, 03080
        • Rekruttering
        • Seoul National University Hospital ( Site 2301)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 82-2-2072-3511
      • Seoul, Sør -Korea, 06351
        • Rekruttering
        • Samsung Medical Center ( Site 2303)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 82-2-3410-0866
    • Kyonggi-do
      • Goyang-si, Kyonggi-do, Sør -Korea, 10408
        • Rekruttering
        • National Cancer Center ( Site 2305)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 82-31-920-1760
    • Seoul
      • Seodaemun-Gu, Seoul, Sør -Korea, 03722
        • Rekruttering
        • Severance Hospital ( Site 2302)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 82-2-2227-7969
      • Songpa-gu, Seoul, Sør -Korea, 05505
        • Rekruttering
        • Asan Medical Center ( Site 2304)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +82-2-3010-3640
  • Taiwan
      • Taichung, Taiwan, 40705
        • Rekruttering
        • Taichung Veterans General Hospital ( Site 2603)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 886423592525x5822
      • Tainan, Taiwan, 704302
        • Rekruttering
        • National Cheng Kung University Hospital ( Site 2602)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +88662353535x5222
      • Taipei, Taiwan, 104
        • Rekruttering
        • Mackay Memorial Hospital ( Site 2604)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +886225433535x3941
      • Taipei, Taiwan, 10002
        • Rekruttering
        • National Taiwan University Hospital ( Site 2601)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 886-223123456x271563
      • Taoyuan, Taiwan, 333
        • Rekruttering
        • Chang Gung Memorial Hospital - Linkou Branch ( Site 2605)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +886-33281200x8258
  • Thailand
    • Bangkok
      • Bangkok, Bangkok, Thailand, 10400
        • Rekruttering
        • Ramathibodi Hospital ( Site 3402)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +6622011451
      • Bangkok, Bangkok, Thailand, 10700
        • Rekruttering
        • Faculty of Medicine Siriraj Hospital ( Site 3401)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +6624194685
  • Tsjekkia
      • Prague, Tsjekkia, 128 08
        • Rekruttering
        • Vseobecna fakultni nemocnice v Praze ( Site 3325)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +420224967451
      • Prague, Tsjekkia, 150 06
        • Rekruttering
        • Fakultni nemocnice v Motole ( Site 3322)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +420224434749
    • Brno-mesto
      • Brno, Brno-mesto, Tsjekkia, 602 00
        • Rekruttering
        • Fakultni Nemocnice Brno Bohunice ( Site 3324)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 420532233843
    • Ostrava Mesto
      • Ostrava-Poruba, Ostrava Mesto, Tsjekkia, 708 52
        • Rekruttering
        • Fakultni nemocnice Ostrava ( Site 3323)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +420597371804
  • Ungarn
    • Bács-Kiskun county
      • Kecskemét, Bács-Kiskun county, Ungarn, 6000
        • Rekruttering
        • Bacs-Kiskun Megyei Korhaz ( Site 3920)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +3676516719
    • Csongrád megye
      • Szeged, Csongrád megye, Ungarn, 6720
        • Rekruttering
        • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Onkoterapias Klinika ( Site 3924)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +36 62 544 596
    • Hajdú-Bihar
      • Debrecen, Hajdú-Bihar, Ungarn, 4032
        • Rekruttering
        • Debreceni Egyetem Klinikai Kozpont ( Site 3922)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 0652255705
    • Pest County
      • Budapest, Pest County, Ungarn, 1122
        • Rekruttering
        • Országos Onkológiai Intézet-Ngyógyászat ( Site 3923)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +3612248600 Ext 3616
      • Budapest, Pest County, Ungarn, 1088
        • Rekruttering
        • Semmelweis Egyetem ( Site 3925)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: +3612660473/54243
  • Østerrike
    • State of Vienna
      • Vienna, State of Vienna, Østerrike, 1090
        • Rekruttering
        • Medizinische Universitat Wien ( Site 0102)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 004314040061030
    • Styria
      • Graz, Styria, Østerrike, 8036
        • Rekruttering
        • Medizinische Universität Graz-Abteilung für Gynäkologie / Onkologie ( Site 0104)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 004331638581081
    • Tyrol
      • Innsbruck, Tyrol, Østerrike, 6020
        • Rekruttering
        • Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 0101)
        • Ta kontakt med:
          • Study Coordinator
          • Telefonnummer: 004351250482403

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

  • Voksen
  • Eldre voksen

Tar imot friske frivillige

Nei

Beskrivelse

Inkluderingskriterier:

  • Har histologisk bekreftet epitelial eggstokk, eggleder eller primær peritoneal karsinom.
  • Har mottatt 4 eller flere sykluser med platinabasert dublett cellegift i førstelinjen og totalt 6 sykluser med karboplatinbasert dublett cellegift i andrelinjesnitt for kreft i eggstokkene (OC).
  • Har platinasensitiv epitel oc,
  • Har gitt vev av en tumorlesjon som ikke tidligere ble bestrålet
  • Menneskelig immunsviktvirus (HIV) -infiserte deltakere må ha godt kontrollert HIV på antiretroviral terapi
  • Deltakere som er hepatitt B overflateantigen -positive er kvalifiserte hvis de har fått hepatitt B -virus (HBV) antiviral terapi i minst 4 uker, og har ikke påvisbar HBV viral belastning før tildeling (del 1) eller randomisering (del 2)
  • Deltakere med en historie med hepatitt C -virus (HCV) -infeksjon er kvalifisert hvis HCV -viral belastning ikke kan påvises ved screening
  • Har en ECOG -ytelsesstatus fra 0 til 1 vurdert innen 7 dager før tildeling (del 1) eller randomisering (del 2)

Eksklusjonskriterier:

  • Har ikke-pitelkreft (kimcellesvulster og kjønnssnor-stromale svulster), grensesvulster (lavt ondartet potensial), slimete, seromukinøs som overveiende er slimete, ondartet Brenners tumor og udifferensiert karsinom
  • Har platinumresistent OC eller Platinum-ildfast OC
  • Har historie med dokumentert alvorlig tørrøysyndrom, alvorlig meibomisk kjertel sykdom og/eller blefaritt, eller hornhinnesykdom som forhindrer/forsinker hornhinnen.
  • Har aktiv inflammatorisk tarmsykdom som krever immunsuppressiv medisiner eller tidligere historie med inflammatorisk tarmsykdom (f.eks. Crohns sykdom, ulcerøs kolitt eller kronisk diaré)
  • Har ukontrollert, betydelig hjerte- og karsykdommer eller cerebrovaskulær sykdom.
  • Har en historie med (ikke -infeksjon) pneumonitt/interstitiell lungesykdom som krevde steroider eller har aktuell pneumonitt/interstitiell lungesykdom.
  • HIV-infiserte deltakere med en historie med Kaposis sarkom og/eller multisentrisk Castleman's sykdom
  • Har mottatt mer enn 2 tidligere linjer med systemisk terapi for OC.
  • Har mottatt tidligere systemisk kreftbehandling
  • Har mottatt tidligere strålebehandling innen 2 uker etter tildeling (del 1) eller randomisering (del 2), eller har strålingsrelaterte toksisiteter, som krever kortikosteroider
  • Har en ekstra malignitet som utvikler seg eller har krevd aktiv behandling i løpet av de siste 3 årene
  • Har aktivt sentralnervesystem (CNS) metastaser og/eller karsinomatøs hjernehinnebetennelse
  • Har en aktiv infeksjon som krever systemisk terapi

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Ingen (Open Label)

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: Del 1: Sacituzumab Tirumotecan + Bevacizumab
Deltakerne mottar 4 mg/kg sacituzumab tirumotekan en gang hver 2. uke (Q2W) pluss 15 mg/kg bevacizumab en gang hver tredje uke (Q3W) via intravenøs (IV) infusjon i løpet av 6 uker
Biologisk: Sacituzumab Tirumotecan
IV -infusjon
Andre navn:
  • SKB264
  • MK-2870
  • sac-TMT
Biologisk: Bevacizumab
IV -infusjon
Andre navn:
  • Avastin
  • MVASI
  • Altusan
Legemiddel: H1 reseptorantagonist
Redningsmedisiner tatt per godkjent produktetikett før Sacituzumab Tirumotecan
Legemiddel: H2 reseptorantagonist
Redningsmedisiner tatt per godkjent produktetikett før Sacituzumab Tirumotecan
Legemiddel: Acetaminophen (eller tilsvarende)
Redningsmedisiner tatt per godkjent produktetikett før Sacituzumab Tirumotecan
Legemiddel: Dexamethason (eller tilsvarende)
Redningsmedisiner tatt per godkjent produktetikett før Sacituzumab Tirumotecan
Legemiddel: Steroid munnskyll (dexamethason eller tilsvarende)
Redningsmedisin tatt oralt 2-4 ganger daglig
Aktiv komparator: Del 2: Standard of Care (SOC)
Deltakerne får lokal standard for omsorg frem til progressiv sykdom eller seponering. Etter legens skjønn får deltakerne 15 mg/kg bevacizumab Q3W via IV -infusjon inntil progressiv sykdom eller seponering.
Biologisk: Bevacizumab
IV -infusjon
Andre navn:
  • Avastin
  • MVASI
  • Altusan
Eksperimentell: Part 2: Sacituzumab tirumotecan
Participants receive 4 mg/kg of sacituzumab tirumotecan Q2W via IV infusion for up to approximately 2 years or until progressive disease or discontinuation. At the physician's discretion, participants receive 15 mg/kg of bevacizumab Q3W via IV infusion until progressive disease or discontinuation.
Biologisk: Sacituzumab Tirumotecan
IV -infusjon
Andre navn:
  • SKB264
  • MK-2870
  • sac-TMT
Biologisk: Bevacizumab
IV -infusjon
Andre navn:
  • Avastin
  • MVASI
  • Altusan
Legemiddel: H1 reseptorantagonist
Redningsmedisiner tatt per godkjent produktetikett før Sacituzumab Tirumotecan
Legemiddel: H2 reseptorantagonist
Redningsmedisiner tatt per godkjent produktetikett før Sacituzumab Tirumotecan
Legemiddel: Acetaminophen (eller tilsvarende)
Redningsmedisiner tatt per godkjent produktetikett før Sacituzumab Tirumotecan
Legemiddel: Dexamethason (eller tilsvarende)
Redningsmedisiner tatt per godkjent produktetikett før Sacituzumab Tirumotecan
Legemiddel: Steroid munnskyll (dexamethason eller tilsvarende)
Redningsmedisin tatt oralt 2-4 ganger daglig

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Part 1: Number of Participants With One or More Adverse Events (AEs)
Tidsramme: Up to 6 weeks
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention.
Up to 6 weeks
Part 1: Number of Participants Who Discontinue Study Intervention Due to an AE
Tidsramme: Up to 6 weeks
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention.
Up to 6 weeks
Part 2: Progression-Free Survival (PFS)
Tidsramme: Up to approximately 4 years
PFS is defined as the time from randomization to the first documented progressive disease (PD) or death from any cause, whichever occurs first. Per RECIST 1.1, PD is defined as at least a 20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm. The appearance of one or more new lesions is also considered PD. PFS as assessed by blinded independent central review (BICR) will be presented.
Up to approximately 4 years

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Part 2: Overall Survival (OS)
Tidsramme: Up to approximately 6 years
OS is defined as the time from randomization to death due to any cause.
Up to approximately 6 years
Part 2: Number of Participants With One or More AEs
Tidsramme: Up to approximately 4 years
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention.
Up to approximately 4 years
Part 2: Number of Participants Who Discontinue Study Intervention Due to an AE
Tidsramme: Up to approximately 4 years
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention.
Up to approximately 4 years
Part 2: Change From Baseline in European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) Global Health Status-Quality of Life Score
Tidsramme: Baseline and up to approximately 4 years
The EORTC-QLQ-C30 is a 30-item questionnaire developed to assess the QoL of cancer patients. Participant responses to Item 30 (""How would you rate your overall quality of life during the past week?") is scored on a 7-point scale (1=Very Poor to 7=Excellent). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher value indicates a better level of function. The change from baseline in EORTC QLQ-C30 Item 30 score will be reported.
Baseline and up to approximately 4 years
Part 2: Change From Baseline in EORTC QLQ-C30 Physical Functioning Score
Tidsramme: Baseline and up to approximately 4 years
The EORTC QLQ-C30 is a 30-item questionnaire to assess the overall quality of life of cancer patients. Participant responses to questions about their physical functioning are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher score indicates a better level of physical functioning.
Baseline and up to approximately 4 years
Part 2: Change From Baseline in EORTC QLQ-C30 Role Functioning Score
Tidsramme: Baseline and up to approximately 4 years
The EORTC QLQ-C30 is a 30-item questionnaire to assess the overall quality of life of cancer patients. Participant responses to the questions "Were you limited in doing either your work or other daily activities during the past week?" and " Were you limited in pursuing your hobbies or other leisure time activities during the past week?" will be scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. Higher scores indicate a more impaired level of role functioning. Change from baseline in the role functioning score will be presented.
Baseline and up to approximately 4 years
Part 2: Change From Baseline in EORTC Quality of Life Questionnaire-Ovarian Cancer Module 28 (QLQ-OV28) abdominal/gastrointestinal (GI) symptom scale
Tidsramme: Baseline and up to approximately 4 years
The EORTC QLQ-OV28 is an OC-specific, and psychometrically and clinically validated module to supplement the EORTC QLQ-C30. The EORTC QLQ-OV28 abdominal/GI symptom scale is scored on a 4-point scale (1=not at all, 2=a little, 3=quite a bit, 4=very much).
Baseline and up to approximately 4 years

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Merck Sharp & Dohme LLC

Samarbeidspartnere

GOG Foundation
European Network of Gynaecological Oncological Trial Groups (ENGOT)

Etterforskere

  • Studieleder: Medical Director, Merck Sharp & Dohme LLC

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Hjelpsomme linker

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

9. april 2025

Primær fullføring (Antatt)

27. april 2029

Studiet fullført (Antatt)

9. november 2032

Datoer for studieregistrering

Først innsendt

7. februar 2025

Først innsendt som oppfylte QC-kriteriene

7. februar 2025

Først lagt ut (Faktiske)

13. februar 2025

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

3. september 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

1. september 2026

Sist bekreftet

1. september 2026

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • 2870-022
  • 2023 (U.S. NIH-stipend/kontrakt: GRAMMY Museum Foundation)
  • MK-2870-022 (Annen identifikator: MSD)
  • TroFuse-022 (Annen identifikator: MSD)
  • U1111-1297-4489 (Registeridentifikator: UTN)
  • GOG-3103 (Annen identifikator: Gynecologic Oncology Group)
  • ENGOT-ov84 (Annen identifikator: European Network of Gynaecological Oncological Trial Groups (ENGOT))
  • jRCT2031240722 (Registeridentifikator: Registry Identifier Japan Registry of Clinical Trials (jRCT))
  • 2023-508015-23-00 (Registeridentifikator: EU CT)

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

JA

IPD-planbeskrivelse

https://trialstransparency.msdclinicaltrials.com/pdf/procedureAccessclinicaltrialdata.pdf

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Ja

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Abonnere