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The Effect of Low-Level Laser Therapy on Accelerating Tooth Movement and Reducing Pain During Orthodontic Treatment (LLLT)

14. mai 2026 oppdatert av: Faris Mohammed Ali Aljobur, Sana'a University
Orthodontic treatment is a common and effective approach to correcting dental malocclusions and improving oral function and aesthetics. The process involves applying mechanical forces to move teeth into their desired positions, which can lead to discomfort and pain for patients, especially during the initial stages of treatment. While the ultimate goal of orthodontic therapy is to achieve proper alignment, the associated pain and the time required to complete the treatment often become significant concerns for patients. (Jheon et al., 2017). The duration of treatment, which typically spans several months or even years, is influenced by various factors including the type of malocclusion, the force applied, and the biological response of the periodontal tissues to the applied forces. (Sangle et al., 2023). Recent advancements in orthodontic care have focused on finding ways to accelerate tooth movement while minimizing the discomfort experienced by patients. Low-level laser therapy (LLLT), also known as photobiomodulation (PBM), has garnered significant attention as a non-invasive method to enhance biological healing processes. LLLT has been shown to stimulate cellular activity, increase collagen production, and improve blood circulation, potentially influencing the rate of tooth movement (Fini et al., 2020). Several studies suggest that LLLT may enhance the osteoclast and osteoblast activity in the periodontal tissues, leading to more rapid bone resorption and apposition, which could expedite the tooth movement process (Suzuki et al., 2016). Additionally, LLLT has been shown to reduce pain perception, possibly by modulating nerve activity and inflammation (Guo et al., 2021).

Studieoversikt

Status

Har ikke rekruttert ennå

Forhold

Intervensjon / Behandling

Studietype

Intervensjonell

Registrering (Antatt)

30

Fase

  • Ikke aktuelt

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

  • Voksen

Tar imot friske frivillige

Ja

Beskrivelse

Inclusion Criteria:

  • Patients aged 15-30 years requiring fixed orthodontic treatment.

    • Extraction treatment plan with bilateral canine retraction.
    • Good oral hygiene and periodontal health.
    • No systemic diseases or medications affecting bone metabolism.

Exclusion Criteria:

  • Previous orthodontic treatment.

    • Smoking or alcohol consumption.
    • Pregnancy or lactation.
    • Use of analgesics or anti-inflammatory drugs during the study period.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Dobbelt

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Sham-komparator: The control group
The control group will receive a sham laser treatment using the same device and procedure as the LLLT group, but without emitting the laser beam. Both the patients and the operator will be blinded to the treatment allocation
Fremgangsmåte: Low level laser therapy

All participants will receive standard orthodontic treatment using appliances. The type of tooth movement studied will include, (e.g., canine retraction, molar distalization). Orthodontic adjustments will be performed at intervals (e.g., every 4 weeks) by a single calibrated orthodontist to ensure consistency of force application. Force magnitude will be monitored using (e.g., strain gauges, force measuring devices) at each adjustment

The LLLT group will receive laser treatment using a Ga-As-Al diode laser operating at a wavelength of 810 nm. The laser parameters will be as follows:

Participants receive low-level laser therapy in addition to standard orthodontic treatment. • The laser device used is a Ga-As-Al diode laser with a wavelength of 810 nm, power output of 100 mW, and energy density of 5 J/cm² (Sousa et al., 2011). • Laser application is performed at specific time points: immediately after bracket placement, on days 3, 7, and 14, and then monthly until the end of the study.

Andre navn:
  • orthodontic
Aktiv komparator: Laser therapy group
The LLLT group will receive laser treatment using a Ga-As-Al diode laser operating at a wavelength of 810 nm
Fremgangsmåte: Low level laser therapy

All participants will receive standard orthodontic treatment using appliances. The type of tooth movement studied will include, (e.g., canine retraction, molar distalization). Orthodontic adjustments will be performed at intervals (e.g., every 4 weeks) by a single calibrated orthodontist to ensure consistency of force application. Force magnitude will be monitored using (e.g., strain gauges, force measuring devices) at each adjustment

The LLLT group will receive laser treatment using a Ga-As-Al diode laser operating at a wavelength of 810 nm. The laser parameters will be as follows:

Participants receive low-level laser therapy in addition to standard orthodontic treatment. • The laser device used is a Ga-As-Al diode laser with a wavelength of 810 nm, power output of 100 mW, and energy density of 5 J/cm² (Sousa et al., 2011). • Laser application is performed at specific time points: immediately after bracket placement, on days 3, 7, and 14, and then monthly until the end of the study.

Andre navn:
  • orthodontic

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
tooth movement measurement
Tidsramme: Tooth Movement Measurement • Method: Cephalometric radiographs will be taken at baseline, 4 weeks, and 8 weeks to assess tooth movement. Linear measurements will be made between specific cephalometric landmarks by a calibrated and blinded examiner using
Tooth Movement Measurement • Method: Cephalometric radiographs will be taken at baseline, 4 weeks, and 8 weeks to assess tooth movement. Linear measurements will be made between specific cephalometric landmarks by a calibrated and blinded examiner using digital imaging software. • Parameters: The distance between the canine and second premolar is measured at baseline and at monthly intervals until the end of the study. • Tool: Digital calipers and specialized software (e.g., OrthoAnalyzer) are used for precise measurements (Ren et al., 2003).
Tooth Movement Measurement • Method: Cephalometric radiographs will be taken at baseline, 4 weeks, and 8 weeks to assess tooth movement. Linear measurements will be made between specific cephalometric landmarks by a calibrated and blinded examiner using

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
pain assessment
Tidsramme: Timing: Pain is assessed at baseline (before treatment) and at 6 hours, 24 hours, 3 days, 7 days, and 14 days after the application of orthodontic force and LLLT/sham irr
Pain Assessment • Tool: Visual Analog Scale (VAS) is used to measure pain levels. • Timing: Pain is assessed at baseline (before treatment) and at 6 hours, 24 hours, 3 days, 7 days, and 14 days after the application of orthodontic force and LLLT/sham irradiation. • Procedure: Participants mark their pain level on a 10 cm line, where 0 indicates no pain and 10 indicates the worst pain imaginable
Timing: Pain is assessed at baseline (before treatment) and at 6 hours, 24 hours, 3 days, 7 days, and 14 days after the application of orthodontic force and LLLT/sham irr

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Sana'a University

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Antatt)

2. juni 2026

Primær fullføring (Antatt)

2. februar 2028

Studiet fullført (Antatt)

2. februar 2028

Datoer for studieregistrering

Først innsendt

25. mars 2026

Først innsendt som oppfylte QC-kriteriene

14. mai 2026

Først lagt ut (Faktiske)

18. mai 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

18. mai 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

14. mai 2026

Sist bekreftet

1. mars 2026

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • (OR:06/05/2025)

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

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