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The Effects of Yoga Practice on Exercise Capacity, Arterial Stiffness, Respiratory Function, Peripheral Muscle Strength, Posture and Quality of Life in Children With Cystic Fibrosis

5. november 2026 oppdatert av: Naciye Vardar-Yagli, Hacettepe University

The aim of this study is to investigate the effects of exercise training applied through telerehabilitation on exercise capacity, peripheral and respiratory muscle strength, arterial stiffness, posture and quality of life in children with cystic fibrosis.

Studieoversikt

Status

Rekruttering

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

The most common problems in patients with cystic fibrosis (CF) are increased bronchial secretions, reduced exercise tolerance and shortness of breath.

Exercise capacity is limited due to muscle dysfunction, inflammation and progressive respiratory disease. Cardiovascular complications are one of the long-term complications of CF. Increased arterial stiffness is an indicator of elevated cardiovascular risk. It has been shown that patients with CF have increased arterial stiffness compared to their healthy peers.

Exercise training has a positive effect on exercise capacity, respiratory function and quality of life in patients with CF. Studies have shown that exercise training applied using the telerehabilitation method increases exercise capacity and improves peripheral muscle function in patients with CF. Peripheral muscle function, functional capacity, arterial stiffness and posture have been assessed in patients with CF. Furthermore, studies have been performed on patients with CF involving exercise training via telerehabilitation.In addition, various studies have shown that yoga and aerobic exercise training have positive effects on arterial stiffness. Although there are only a few studies involving patients with CF who practise yoga, no study has been found that assesses the effects of yoga practise via telerehabilitation on exercise capacity, peripheral and respiratory muscle function, and arterial stiffness.The purpose of this study is to examine the effects of exercise training using telerehabilitation on exercise capacity, peripheral and respiratory muscle strength, arterial stiffness, posture and quality of life in children with CF.

Children were randomly assigned to three groups: The first group will receive online aerobic exercise training and yoga sessions. The second group will receive only aerobic exercise training.The third group will be informed about the importance of physical activity and will be given recommendations for physical activity. Participants' respiratory function, exercise capacity, arterial stiffness parameters, peripheral muscle function, posture and quality of life questionnaire will be evaluated initially and following an 8-week exercise programme.

Studietype

Intervensjonell

Registrering (Antatt)

36

Fase

  • Ikke aktuelt

Kontakter og plasseringer

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Studiekontakt

Studiesteder

Deltakelseskriterier

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Kvalifikasjonskriterier

Alder som er kvalifisert for studier

8 år til 18 år (Barn, Voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion Criteria:

  • Patients aged 8-18 years with a diagnosis of cystic fibrosis (CF)
  • Access to online exercise training
  • Percent predicted of forced expiratory volume at one second (FEV1) > 40% in pulmonary function test

Exclusion Criteria:

  • Being diagnosed with acute pulmonary exacerbation at the time of study and /or within the last month.
  • Being physically or perceptually competent to exercise
  • Patients with allergic bronchopulmonary aspergillosis who were treated with systemic steroid therapy

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Enkelt

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: Combined Group

aerobic exercise training and yoga sessions in patients with cystic fibrosis
Annen: aerobic exercises + yoga

Patients will be performed online in groups of 3-4 participants supervised aerobic exercises and yoga sessions. Aerobic exercises will be applied for 8 weeks, for 30-45 minutes, at 65-75% of the maximum heart rate, 3 days a week, on the days when yoga sessions are not performed. The yoga sessions will consist of 30-40-minute sessions, with three sessions per week for eight weeks. The yoga sessions will consist of three core components - asana (postures), pranayama (breathing) and meditation (focus).
Eksperimentell: aerobic group

only aerobic exercises in patients with cystic fibrosis
Annen: aerobic exercises

Patients will be performed online in groups of 3-4 participants supervised only aerobic exercises Aerobic exercises will be applied for 8 weeks, for 30-45 minutes, at 65-75% of the maximum heart rate, 3 days a week.
Eksperimentell: control group

physical activity recommendations in patients with cystic fibrosis
Annen: Physical activity recommendations

Patients will be informed of the benefits of physical activity and appropriate physical activity recommendations will be provided.

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
six minute walk test
Tidsramme: before the exercise training

the distance reached in the six-minute walk test
before the exercise training
six minute walk test
Tidsramme: eigth week

the distance reached in the six-minute walk test
eigth week

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Arterial stiffness
Tidsramme: before the exercise training

Arterial stiffness will be assessed non-invasively using the Mobil-O-GRAPH (I.E.M., Stolberg, Germany).
before the exercise training
Arterial stiffness
Tidsramme: eight week

Arterial stiffness will be assessed non-invasively using the Mobil-O-GRAPH (I.E.M., Stolberg, Germany).
eight week
Respiratory muscle strength
Tidsramme: before the exercise training

Respiratory muscle strength will be evaluated using mouth pressure device
before the exercise training
Respiratory muscle strength
Tidsramme: eight week

Respiratory muscle strength will be evaluated using mouth pressure device
eight week
respiratory muscle endurance
Tidsramme: before the exercise training

Respiratory muscle endurance will be assessed using constant load test
before the exercise training
respiratory muscle endurance
Tidsramme: eight week

Respiratory muscle endurance will be assessed using constant load test
eight week
Pulmonary functions-FVC
Tidsramme: before the exercise training

Forced vital capacity (FVC)
before the exercise training
Pulmonary functions-FVC
Tidsramme: eight week

Forced vital capacity (FVC)
eight week
Pulmonary functions-FEV1
Tidsramme: before the exercise training

Forced expiratory volume in the first second (FEV1)
before the exercise training
Pulmonary functions-FEV1
Tidsramme: eigth week

Forced expiratory volume in the first second (FEV1)
eigth week
Pulmonary functions-FEV1/FVC
Tidsramme: before the exercise training

FEV1/ FVC
before the exercise training
Pulmonary functions-FEV1/FVC
Tidsramme: eight week

FEV1/ FVC
eight week
Pulmonary functions-FEF25-75
Tidsramme: before the exercise training

Forced mid-expiratory flow (FEF25-75)
before the exercise training
Pulmonary functions-FEF25-75
Tidsramme: eigth week

Forced mid-expiratory flow (FEF25-75)
eigth week
Peripheral muscle strength
Tidsramme: before the exercise training

Peripheral muscle strength will be assessed using dynamometer
before the exercise training
Peripheral muscle strength
Tidsramme: eigth week

Peripheral muscle strength will be assessed using dynamometer
eigth week
1 minute sit to stand test (STS) repetitions
Tidsramme: before the exercise training

number of sit to stand for one minute is recorded
before the exercise training
1 minute sit to stand test (STS) repetitions
Tidsramme: eight week

number of sit to stand for one minute is recorded
eight week
posture
Tidsramme: before the exercise training

Posture will be assessed using Corbin Postural Assessment scale. Lateral and posterior views will be assessed (0 = absent,1 = mild, 2 = moderate, 3 = severe) and posture score will be determined as excellent(0-2), very good (3-4), good (5-7), fair (8-11)and poor (>12).
before the exercise training
posture
Tidsramme: eigth week

Posture will be assessed using Corbin Postural Assessment scale. Lateral and posterior views will be assessed (0 = absent,1 = mild, 2 = moderate, 3 = severe) and posture score will be determined as excellent(0-2), very good (3-4), good (5-7), fair (8-11)and poor (>12).
eigth week
Quality of life assessment
Tidsramme: before the exercise training

Quality of life will be assessed using the Cystic Fibrosis Questionnaire-Revised .The Cystic Fibrosis Questionnaire-Revised is a disease-specific health-related quality of life measure for children, adolescents with cystic fibrosis (CF). The questionnaire evaluate physical functioning, emotional functioning, social functioning, body image, eating disorders, treatment,respiratory symptoms and digestive symptoms. Score range is 0-100. Higher scores indicating higher health-related qualityof life.
before the exercise training
Quality of life assessment
Tidsramme: eigth week

Quality of life will be assessed using the Cystic Fibrosis Questionnaire-Revised .The Cystic Fibrosis Questionnaire-Revised is a disease-specific health-related quality of life measure for children, adolescents with cystic fibrosis (CF). The questionnaire evaluate physical functioning, emotional functioning, social functioning, body image, eating disorders, treatment,respiratory symptoms and digestive symptoms. Score range is 0-100. Higher scores indicating higher health-related quality of life.
eigth week

Samarbeidspartnere og etterforskere

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Sponsor

Hacettepe University

Etterforskere

  • Hovedetterforsker: Naciye Vardar-Yagli, PhD, Hacettepe University

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

10. juli 2025

Primær fullføring (Antatt)

1. juli 2027

Studiet fullført (Antatt)

1. juli 2027

Datoer for studieregistrering

Først innsendt

5. november 2026

Først innsendt som oppfylte QC-kriteriene

5. november 2026

Først lagt ut (Faktiske)

12. november 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

12. november 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

5. november 2026

Sist bekreftet

1. oktober 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • FTREK25/92

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