Randomized Trial Of Exemestane Versus Continued Tamoxifen In Postmenopausal Women With Early Breast Cancer (IES)
21 kwietnia 2014 zaktualizowane przez: Pfizer
Randomized Double-Blind Trial In Postmenopausal Women With Primary Breast Cancer Who Have Received Adjuvant Tamoxifen For 2-3 Years, Comparing Subsequent Adjuvant Exemestane Treatment With Further Tamoxifen
To compare the sequential administration of exemestane with administration of further tamoxifen until 5 years in postmenopausal women with operable breast cancer who have already received 2-3 years of adjuvant tamoxifen, in terms of disease-free survival (DFS), overall survival (OS), incidence of contralateral breast cancer and long-term tolerability.
Przegląd badań
Typ studiów
Interwencyjne
Zapisy (Rzeczywisty)
4740
Faza
- Faza 3
Kontakty i lokalizacje
Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.
Lokalizacje studiów
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Observatory, Afryka Południowa, 7925
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Gauteng
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Johannesburg, Gauteng, Afryka Południowa, 2196
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Buenos Aires, Argentyna, 1181
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Cordoba, Argentyna, X5000AA1
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Buenos Aires
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Haedo, Buenos Aires, Argentyna, 1706
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San Isidro, Buenos Aires, Argentyna, 1642
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San Martin, Buenos Aires, Argentyna, 1650
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Capital Federal
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Buenos Aires, Capital Federal, Argentyna, 1406
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Buenos Aires, Capital Federal, Argentyna
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Buenos Aires, Capital Federal, Argentyna, 1426
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Buenos Aires, Capital Federal, Argentyna, 1417
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Buenos Aires, Capital Federal, Argentyna, 1425
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Pcia. de Santa Fe
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Rosario 2000, Pcia. de Santa Fe, Argentyna
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Santa Fe
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Rosario, Santa Fe, Argentyna, 2000
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New South Wales
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Camperdown, New South Wales, Australia, 2050
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Dubbo, New South Wales, Australia, 2830
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Liverpool, New South Wales, Australia, 2170
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Waratah, New South Wales, Australia, 2298
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South Australia
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Adelaide, South Australia, Australia, 5000
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Victoria
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Bendigo, Victoria, Australia, 3552
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Box Hill, Victoria, Australia, 3128
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Ringwood East, Victoria, Australia, 3135
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Antwerpen, Belgia, 2020
- Pfizer Investigational Site
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Arlon, Belgia, 6700
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Baudour, Belgia, 7331
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Brasschaat, Belgia, 2930
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Bruxelles, Belgia, 1000
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Bruxelles, Belgia, 1180
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Charleroi, Belgia, 6000
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Edegem, Belgia, 2650
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Genk, Belgia, 3600
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Haine St. Paul, Belgia, 7100
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Hasselt, Belgia, 3500
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Kraainem, Belgia, 1950
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La Louviere, Belgia, 7100
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Leuven, Belgia, 3000
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Liege, Belgia, 4000
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Merksem, Belgia, 2170
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Namur, Belgia, 5000
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Verviers, Belgia, 4800
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Wilrijk, Belgia, 2610
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Sarajevo, Bośnia i Hercegowina, 71000
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Plovdiv, Bułgaria, 4004
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Sofia, Bułgaria, 1756
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Sofia, Bułgaria, 1504
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Sofia, Bułgaria, 1784
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Stara Zagora, Bułgaria, 6003
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Osijek, Chorwacja
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Split, Chorwacja
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Zagreb, Chorwacja, 10000
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Zagreb, Chorwacja
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Aarhus C, Dania, 8000
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Esbjerg, Dania, 6700
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Herlev, Dania, 2730
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Herning, Dania, 7400
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Hilleroed, Dania, 3400
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Koebenhavn OE, Dania, 2100
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Naestved, Dania, 4700
- Pfizer Investigational Site
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Roskilde, Dania, 4000
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Vejle, Dania, 7100
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Viborg, Dania, 8800
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Cairo, Egipt
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Tartu, Estonia, 51014
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St. Petersburg, Federacja Rosyjska, 197758
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Angers, Francja, 49033 Cedex 01
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Annecy Cedex, Francja, 74011
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Avignon Cedex 2, Francja, 84082
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Bordeaux, Francja, 33030 Cedex
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Bordeaux, Francja, 33300 Cedex
- Pfizer Investigational Site
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Brest, Francja, 29609 Cedex
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Caen, Francja, 14052 Cedex
- Pfizer Investigational Site
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Caen Cedex 05, Francja, 14076
- Pfizer Investigational Site
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Clermont Ferrand, Francja, 63011
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Evreux, Francja, 27000
- Pfizer Investigational Site
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Lagny Sur Marne, Francja, 77405 Cedex
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Le Havre, Francja, 76600
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Le Mans, Francja, 72000
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Lille, Francja, 59020 Cedex
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Lyon, Francja, 69373
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Marseille, Francja, 13273
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Meaux, Francja, 77100
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Montbeliard, Francja, 25209 Cedex
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Mulhouse, Francja, 68070 Cedex
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Nice, Francja, 06189
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Paris, Francja, 75248 Cedex 5
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Paris, Francja, 75970 Cedex 20
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Perpignan, Francja, 66046
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Rennes, Francja, 35042
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Rouen, Francja, 76038 Cedex
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Saint-Herblain, Francja, 44805
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St Cloud, Francja, 92210
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Strasbourg, Francja, 67091 Cedex
- Pfizer Investigational Site
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Toulouse, Francja, 31502
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Attiki
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Athens, Attiki, Grecja, 115 22
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Athens, Attiki, Grecja, 115 28
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Crete
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Heraklion, Crete, Grecja, 71 110
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Albacete, Hiszpania, 02006
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Alicante, Hiszpania, 03010
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Badajoz, Hiszpania, 06008
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Badajoz, Hiszpania, 06080
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Cordoba, Hiszpania, 14004
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Guadalajara, Hiszpania, 19002
- Pfizer Investigational Site
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Lleida, Hiszpania, 25198
- Pfizer Investigational Site
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Madrid, Hiszpania, 28034
- Pfizer Investigational Site
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Madrid, Hiszpania, 28041
- Pfizer Investigational Site
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Madrid, Hiszpania, 28040
- Pfizer Investigational Site
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Valencia, Hiszpania, 46014
- Pfizer Investigational Site
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Zaragoza, Hiszpania, 50009
- Pfizer Investigational Site
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Alicante
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Alcoy, Alicante, Hiszpania, 03804
- Pfizer Investigational Site
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Elche, Alicante, Hiszpania, 03203
- Pfizer Investigational Site
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San Juan de Alicante, Alicante, Hiszpania, 03550
- Pfizer Investigational Site
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Sant Joan D'Alacant, Alicante, Hiszpania, 03550
- Pfizer Investigational Site
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Barcelona
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Badalona, Barcelona, Hiszpania, 08916
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Badalona, Barcelona, Hiszpania, 08911
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Terrassa, Barcelona, Hiszpania, 08227
- Pfizer Investigational Site
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Terrassa, Barcelona, Hiszpania, 08221
- Pfizer Investigational Site
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Guipuzcoa
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San Sebastian, Guipuzcoa, Hiszpania, 20014
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Huesca
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Barbastro, Huesca, Hiszpania, 22300
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Tarragona
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Reus, Tarragona, Hiszpania, 43201
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Amersfoort, Holandia, 3818 ES
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Amsterdam, Holandia, 1105 AZ
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Amsterdam, Holandia, 1066 CX
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Amsterdam, Holandia, 1061 AE
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Apeldoorn, Holandia, 7300 DS
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Blaricum, Holandia, 1261 AN
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Breda, Holandia, 4818 CK
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Delft, Holandia, 2625 AD
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Den Haag, Holandia, 2545 CH
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Eindhoven, Holandia, 5623 EJ
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Enschede, Holandia, 7513 ER
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Groningen, Holandia, 9728 NZ
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Groningen, Holandia, 9700 RM
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Hengelo, Holandia, 7555 DL
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Leeuwarden, Holandia, 8934 AD
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Leiden, Holandia, 2333 ZA
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Leidschendam, Holandia, 2262 BA
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Podybus 90153, Holandia, 5200 ME Den Bosch
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Roermond, Holandia, 6043 CV
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Sittard, Holandia, 6131 BK
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Utrecht, Holandia, 3582 KE
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Veldhoven, Holandia, 5504 DB
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Zaandam, Holandia, 1502 DV
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New Territories, Hongkong
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Cork, Irlandia
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Cork, Ireland, Irlandia
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Dublin, Irlandia
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Dublin 9, Irlandia
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Galway, Irlandia
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Haifa, Izrael
- Pfizer Investigational Site
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Haifa, Izrael, 34362
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Jerusalem, Izrael, 91120
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Jerusalem, Izrael
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Kfar Saba, Izrael
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Petah Tikva, Izrael
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Rehovot, Izrael
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Luxembourg, Luksemburg, 1210
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Floriana, Malta, VLT 14
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Berlin, Niemcy, 10117
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Berlin, Niemcy, 13353
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Chemnitz, Niemcy, 09126
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Erlangen, Niemcy, 91054
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Freiburg, Niemcy, 79106
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Gera, Niemcy, 07548
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Greiz, Niemcy, 07973
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Halle, Niemcy, 06120
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Halle, Niemcy, 06110
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Hamburg, Niemcy, 22081
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Hildburghausen, Niemcy, 98646
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Leipzig, Niemcy, 04129
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Luebeck, Niemcy, 23538
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Muenchen, Niemcy, 80335
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Riesa, Niemcy, 01589
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Rodewisch, Niemcy, 08228
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Saarbruecken, Niemcy, 66113
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Suhl, Niemcy, 98527
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Weiden, Niemcy, 92637
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Bergen, Norwegia, 5021
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Bodo, Norwegia, 8092
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Fredrikstad, Norwegia, 1603
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Haugesund, Norwegia, 5390
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Levanger, Norwegia, 7600
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Mo i Rana, Norwegia, 8607
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Molde, Norwegia, 6407
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Notodden, Norwegia, 3674
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Oslo, Norwegia
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Rissa, Norwegia, 7100
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Rjukan, Norwegia, 3660
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Sandefjord, Norwegia
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Tonsberg, Norwegia, 3103
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Tromso, Norwegia, 9038
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Tromsø, Norwegia, 9038
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Auckland, Nowa Zelandia, 1142
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Waikato
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Hamilton, Waikato, Nowa Zelandia, 2021
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Lima, Peru, L34
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Gdansk, Polska, 80-952
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Gliwice, Polska, 44-101
- Pfizer Investigational Site
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Krakow, Polska, 31-115
- Pfizer Investigational Site
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Krakow, Polska, 31-826
- Pfizer Investigational Site
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Lodz, Polska, 93-509
- Pfizer Investigational Site
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Opole, Polska, 45-060
- Pfizer Investigational Site
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Poznan, Polska, 61-878
- Pfizer Investigational Site
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Sopot, Polska, 81-756
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Warszawa, Polska, 02-781
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Coimbra, Portugalia, 3040
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Coimbra, Portugalia
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Evora, Portugalia, 7000-811
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Brno, Republika Czeska, 656 53
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Ceske Budejovice, Republika Czeska, 370 87
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Prague 2, Republika Czeska, 12808
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Bucuresti, Rumunia, 72435
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Cluj Napoca, Rumunia, 400015
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Timisoara, Rumunia, 300223
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Belgrade, Serbia, 11000
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Sremska Kamenica, Serbia, 21204
- Pfizer Investigational Site
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Alabama
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Birmingham, Alabama, Stany Zjednoczone, 35205
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Birmingham, Alabama, Stany Zjednoczone, 35213
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Birmingham, Alabama, Stany Zjednoczone, 35235
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Arizona
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Green Valley, Arizona, Stany Zjednoczone, 85614
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Green Velley, Arizona, Stany Zjednoczone, 85614
- Pfizer Investigational Site
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Tucson, Arizona, Stany Zjednoczone, 85715
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Tucson, Arizona, Stany Zjednoczone, 85712
- Pfizer Investigational Site
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Tucson, Arizona, Stany Zjednoczone, 85710
- Pfizer Investigational Site
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Tucson, Arizona, Stany Zjednoczone, 85704
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Tucson, Arizona, Stany Zjednoczone, 85745
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Colorado
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Boulder, Colorado, Stany Zjednoczone, 80304
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Colorado Springs, Colorado, Stany Zjednoczone, 80909
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Denver, Colorado, Stany Zjednoczone, 80218
- Pfizer Investigational Site
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Fort Collins, Colorado, Stany Zjednoczone, 80528
- Pfizer Investigational Site
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Lakewood, Colorado, Stany Zjednoczone, 80228
- Pfizer Investigational Site
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Thornton, Colorado, Stany Zjednoczone, 80260
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Florida
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Jacksonville, Florida, Stany Zjednoczone, 32207
- Pfizer Investigational Site
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Jacksonville, Florida, Stany Zjednoczone, 32204
- Pfizer Investigational Site
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Jacksonville Beach, Florida, Stany Zjednoczone, 32250
- Pfizer Investigational Site
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Ocala, Florida, Stany Zjednoczone, 34474
- Pfizer Investigational Site
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Orange Park, Florida, Stany Zjednoczone, 32073
- Pfizer Investigational Site
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Indiana
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Fishers, Indiana, Stany Zjednoczone, 46038
- Pfizer Investigational Site
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Fishers, Indiana, Stany Zjednoczone, 46037
- Pfizer Investigational Site
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Indianapolis, Indiana, Stany Zjednoczone, 46227
- Pfizer Investigational Site
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Indianapolis, Indiana, Stany Zjednoczone, 46219
- Pfizer Investigational Site
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Indianapolis, Indiana, Stany Zjednoczone, IN 46219
- Pfizer Investigational Site
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Iowa
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Cedar Rapids, Iowa, Stany Zjednoczone, 52403
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Massachusetts
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Pittsfield, Massachusetts, Stany Zjednoczone, 01201
- Pfizer Investigational Site
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New York
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Albany, New York, Stany Zjednoczone, 12206
- Pfizer Investigational Site
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Latham, New York, Stany Zjednoczone, 12110-0610
- Pfizer Investigational Site
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Oregon
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Portland, Oregon, Stany Zjednoczone, 97225
- Pfizer Investigational Site
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Portland, Oregon, Stany Zjednoczone, 97227
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Texas
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Arlington, Texas, Stany Zjednoczone, 76014-2084
- Pfizer Investigational Site
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Bedford, Texas, Stany Zjednoczone, 76022
- Pfizer Investigational Site
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Dallas, Texas, Stany Zjednoczone, 75231
- Pfizer Investigational Site
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Dallas, Texas, Stany Zjednoczone, 75230-2510
- Pfizer Investigational Site
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Dallas, Texas, Stany Zjednoczone, 75246
- Pfizer Investigational Site
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El Paso, Texas, Stany Zjednoczone, 79902
- Pfizer Investigational Site
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El Paso, Texas, Stany Zjednoczone, 79915
- Pfizer Investigational Site
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Garland, Texas, Stany Zjednoczone, 75042
- Pfizer Investigational Site
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Houston, Texas, Stany Zjednoczone, 77030
- Pfizer Investigational Site
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Houston, Texas, Stany Zjednoczone, 77024
- Pfizer Investigational Site
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Houston, Texas, Stany Zjednoczone, 77074
- Pfizer Investigational Site
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Houston, Texas, Stany Zjednoczone, 77029
- Pfizer Investigational Site
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Longview, Texas, Stany Zjednoczone, 75601
- Pfizer Investigational Site
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McAllen, Texas, Stany Zjednoczone, 78503
- Pfizer Investigational Site
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Mesquite, Texas, Stany Zjednoczone, 75150
- Pfizer Investigational Site
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Odessa, Texas, Stany Zjednoczone, 79761
- Pfizer Investigational Site
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Pasadena, Texas, Stany Zjednoczone, 77502
- Pfizer Investigational Site
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Plano, Texas, Stany Zjednoczone, 75075-7787
- Pfizer Investigational Site
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San Antonio, Texas, Stany Zjednoczone, 78217
- Pfizer Investigational Site
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Sherman, Texas, Stany Zjednoczone, 75090
- Pfizer Investigational Site
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Sugar Land, Texas, Stany Zjednoczone, 77479
- Pfizer Investigational Site
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Tyler, Texas, Stany Zjednoczone, 75702
- Pfizer Investigational Site
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Weslaco, Texas, Stany Zjednoczone, 78596
- Pfizer Investigational Site
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Washington
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Spokane, Washington, Stany Zjednoczone, 99202
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Spokane, Washington, Stany Zjednoczone, 99218
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Basel, Szwajcaria, CH-4031
- Pfizer Investigational Site
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Bellinzona, Szwajcaria, CH-6500
- Pfizer Investigational Site
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Bern, Szwajcaria, 3010
- Pfizer Investigational Site
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Bern, Szwajcaria, CH-3012
- Pfizer Investigational Site
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Genève, Szwajcaria, CH-1211
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Boras, Szwecja, 501 82
- Pfizer Investigational Site
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Borås, Szwecja, 50182
- Pfizer Investigational Site
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Goteborg, Szwecja, 413 45
- Pfizer Investigational Site
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Halmstad, Szwecja, 301 85
- Pfizer Investigational Site
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Helsingborg, Szwecja, 251 87
- Pfizer Investigational Site
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Kristianstad, Szwecja, 291 85
- Pfizer Investigational Site
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Linkoping, Szwecja, 581 85
- Pfizer Investigational Site
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Lund, Szwecja, 221 85
- Pfizer Investigational Site
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Malmo, Szwecja, 205 02
- Pfizer Investigational Site
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Motala, Szwecja, 591 85
- Pfizer Investigational Site
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Norrkoping, Szwecja, 601 82
- Pfizer Investigational Site
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Nässjö, Szwecja, 575 81
- Pfizer Investigational Site
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Varnamo, Szwecja, 331 85
- Pfizer Investigational Site
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Vasteras, Szwecja, 721 89
- Pfizer Investigational Site
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Vastervik, Szwecja, 59381
- Pfizer Investigational Site
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Vaxjo, Szwecja, 351 85
- Pfizer Investigational Site
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Banska Bystrica, Słowacja, 97517
- Pfizer Investigational Site
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Bratislava, Słowacja, SK-83310
- Pfizer Investigational Site
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Kosice, Słowacja, 041 90
- Pfizer Investigational Site
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Ljubljana, Słowenia, 1000
- Pfizer Investigational Site
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Budapest, Węgry, 1082
- Pfizer Investigational Site
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Budapest, Węgry, 1122
- Pfizer Investigational Site
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Budapest, Węgry, 1145
- Pfizer Investigational Site
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Alba (CN), Włochy, 12051
- Pfizer Investigational Site
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Aviano (PN), Włochy, 33081
- Pfizer Investigational Site
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Bergamo, Włochy, 24128
- Pfizer Investigational Site
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Biella, Włochy, 13900
- Pfizer Investigational Site
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Cagliari, Włochy, 09121
- Pfizer Investigational Site
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Casale Monferrato, AL, Włochy, 15033
- Pfizer Investigational Site
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Correggio, Włochy, 42015
- Pfizer Investigational Site
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Cremona, Włochy, 26100
- Pfizer Investigational Site
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Cuneo, Włochy, 12100
- Pfizer Investigational Site
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Fermo FM, Włochy, 63023
- Pfizer Investigational Site
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Firenze, Włochy, 50134
- Pfizer Investigational Site
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Genova, Włochy, 16132
- Pfizer Investigational Site
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Genova, Włochy, 16128
- Pfizer Investigational Site
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Lecco, Włochy, 23900
- Pfizer Investigational Site
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Lodi, Włochy, 20075
- Pfizer Investigational Site
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Mantova, Włochy, 46100
- Pfizer Investigational Site
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Milano, Włochy, 20133
- Pfizer Investigational Site
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Milano, Włochy, 20121
- Pfizer Investigational Site
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Milano, Włochy, 20141
- Pfizer Investigational Site
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Milano, Włochy, 21053
- Pfizer Investigational Site
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Modena, Włochy, 41100
- Pfizer Investigational Site
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Monserrato (CA), Włochy, 09042
- Pfizer Investigational Site
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Monza, Włochy, 20052
- Pfizer Investigational Site
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Napoli, Włochy, 80131
- Pfizer Investigational Site
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Palermo, Włochy, 90139
- Pfizer Investigational Site
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Parma, Włochy, 43100
- Pfizer Investigational Site
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Perugia, Włochy, 06132
- Pfizer Investigational Site
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Piacenza, Włochy, 29100
- Pfizer Investigational Site
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Pietra Ligure (SV), Włochy, 17027
- Pfizer Investigational Site
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Pisa, Włochy, 56100
- Pfizer Investigational Site
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Reggio Emilia, Włochy, 42100
- Pfizer Investigational Site
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Roma, Włochy, 00148
- Pfizer Investigational Site
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Sassari, Włochy, 07100
- Pfizer Investigational Site
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Terni, Włochy, 05100
- Pfizer Investigational Site
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Thiene (VI), Włochy, 36016
- Pfizer Investigational Site
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Torino, Włochy, 10126
- Pfizer Investigational Site
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Tortona, Włochy, 15057
- Pfizer Investigational Site
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Trescore Balneario BG, Włochy, 24069
- Pfizer Investigational Site
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Treviglio (BG), Włochy, 24047
- Pfizer Investigational Site
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Varese, Włochy, 21100
- Pfizer Investigational Site
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Modena
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Carpi, Modena, Włochy, 41012
- Pfizer Investigational Site
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Belfast, Zjednoczone Królestwo, BT97AB
- Pfizer Investigational Site
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Bradford, Zjednoczone Królestwo, BD9 6RJ
- Pfizer Investigational Site
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Bristol, Zjednoczone Królestwo, BS10 5NB
- Pfizer Investigational Site
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Cardiff, Zjednoczone Królestwo, CF14 2TL
- Pfizer Investigational Site
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Coventry, Zjednoczone Królestwo, CV2 2DX
- Pfizer Investigational Site
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East Kilbride, Zjednoczone Królestwo, G75 8RG
- Pfizer Investigational Site
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Huddersfield, Zjednoczone Królestwo, HD3 3EA
- Pfizer Investigational Site
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Leeds, Zjednoczone Królestwo, LS9 7TF
- Pfizer Investigational Site
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Leeds, Zjednoczone Królestwo, LS1 3EX
- Pfizer Investigational Site
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Lincoln, Zjednoczone Królestwo
- Pfizer Investigational Site
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London, Zjednoczone Królestwo, W6 8RF
- Pfizer Investigational Site
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London, Zjednoczone Królestwo, NW3 2QG
- Pfizer Investigational Site
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London, Zjednoczone Królestwo, N18 1QX
- Pfizer Investigational Site
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London, Zjednoczone Królestwo, SW17 0QT
- Pfizer Investigational Site
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London, Zjednoczone Królestwo, N19 5NF
- Pfizer Investigational Site
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Luton, Zjednoczone Królestwo, LU4 0DZ
- Pfizer Investigational Site
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Manchester, Zjednoczone Królestwo, M20 4BX
- Pfizer Investigational Site
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Sheffield, Zjednoczone Królestwo, S10 2SJ
- Pfizer Investigational Site
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Shrewsbury, Zjednoczone Królestwo
- Pfizer Investigational Site
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Somerset, Zjednoczone Królestwo, BA21 4AT
- Pfizer Investigational Site
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Southampton, Zjednoczone Królestwo, S016 6YD
- Pfizer Investigational Site
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Steeton, Zjednoczone Królestwo, BD20 6TD
- Pfizer Investigational Site
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Stoke on Trent, Zjednoczone Królestwo, ST4 6QG
- Pfizer Investigational Site
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Telford, Zjednoczone Królestwo, TF1 6TF
- Pfizer Investigational Site
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Wythenshawe, Manchester, Zjednoczone Królestwo, M23 9LT
- Pfizer Investigational Site
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Cambs
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Huntingdon, Cambs, Zjednoczone Królestwo, PE18 8NT
- Pfizer Investigational Site
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Dorset
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Bournemouth, Dorset, Zjednoczone Królestwo, BH7 7DW
- Pfizer Investigational Site
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East Yorkshire
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Hull, East Yorkshire, Zjednoczone Królestwo, HU16 5JQ
- Pfizer Investigational Site
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Essex
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Epping, Essex, Zjednoczone Królestwo, CM166TN
- Pfizer Investigational Site
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Westcliff-On-Sea, Essex, Zjednoczone Królestwo, SS0 0RY
- Pfizer Investigational Site
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Gwent
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Newport, Gwent, Zjednoczone Królestwo, NP6 2UB
- Pfizer Investigational Site
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Gwynedd
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Bangor, Gwynedd, Zjednoczone Królestwo, LL57 2PW
- Pfizer Investigational Site
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Halifax
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Salterhebble, Halifax, Zjednoczone Królestwo, HX6 0PW
- Pfizer Investigational Site
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Hants
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Gosport, Hants, Zjednoczone Królestwo, PO12 2AA
- Pfizer Investigational Site
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Middlesex
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Northwood, Middlesex, Zjednoczone Królestwo, HA6 2RN
- Pfizer Investigational Site
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N. Ireland
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Londonderry, N. Ireland, Zjednoczone Królestwo, BT47 1SB
- Pfizer Investigational Site
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N. Yorkshire
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Harrogate, N. Yorkshire, Zjednoczone Królestwo, HG2 7SX
- Pfizer Investigational Site
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Somerset
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Taunton, Somerset, Zjednoczone Królestwo, TA1 5DA
- Pfizer Investigational Site
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South Wales
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Swansea, South Wales, Zjednoczone Królestwo, SA2 8QA
- Pfizer Investigational Site
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Yorkshire
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York, Yorkshire, Zjednoczone Królestwo, Y03 7He
- Pfizer Investigational Site
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Kryteria uczestnictwa
Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.
Kryteria kwalifikacji
Wiek uprawniający do nauki
30 lat i starsze (Dorosły, Starszy dorosły)
Akceptuje zdrowych ochotników
Nie
Płeć kwalifikująca się do nauki
Kobieta
Opis
Inclusion Criteria:
- postmenopausal women with histologically or cytologically confirmed primary breast adenocarcinoma, receiving tamoxifen and have been treated with tamoxifen continuously for between 2 and 3 years and one month, and still free of disease
Exclusion Criteria:
- unresectable breast cancer
- ER negative primary tumor
Plan studiów
Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.
Jak projektuje się badanie?
Szczegóły projektu
- Główny cel: Leczenie
- Przydział: Randomizowane
- Model interwencyjny: Przydział równoległy
- Maskowanie: Podwójnie
Broń i interwencje
Grupa uczestników / Arm |
Interwencja / Leczenie |
|---|---|
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Aktywny komparator: B
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Tamoxifen 20 mg/day tablets administered p.o. for a period ranging from 2.5 to 3 years.
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Eksperymentalny: A
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Exemestane 25 mg/day tablets administered p.o. for a period ranging from 2.5 to 3 years.
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Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
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Disease-Free Survival (DFS) at Month 36 Post-Randomization: Main Study
Ramy czasowe: Baseline up to Month 36
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DFS defined as time from randomization to earliest documentation of breast cancer relapse or death from any cause.
DFS at Month 36 post-randomization was defined as probability of participants alive and disease-free at 36 months after the randomization.
Participants withdrawn from the study for any reason in the absence of relapse were censored at the date they were last seen.
Relapse was categorized as follows: loco-regional: ipsilateral breast or axillary nodal relapse; distant: distant relapse, including supraclavicular nodes; second primary breast cancer: contralateral breast cancer, excluding ductal carcinoma in situ.
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Baseline up to Month 36
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Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
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Overall Survival (OS) at Month 36 Post-Randomization: Main Study
Ramy czasowe: Baseline up to Month 120
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OS was defined as the duration from randomization to death (due to any cause).
OS at Month 36 post-randomization was defined as probability of participants' survival at 36 months after the randomization.
For participants who were alive, OS was censored at the last available assessment.
Probability of OS at Month 36 post-randomization was reported using Kaplan-Meier estimates at Month 36 post-randomization based on 120-month follow-up data.
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Baseline up to Month 120
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Number of Events of Second Breast Cancer in Contralateral Breast: Main Study
Ramy czasowe: Baseline up to Month 120
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Number of events of second primary breast cancer in contralateral breast (excluding ductal carcinoma in situ) were reported.
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Baseline up to Month 120
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Percent Change From Baseline in Lumbar Spine and Proximal Femur (Total Hip) Bone Mineral Density (BMD) at 6, 12, 24 Months On-treatment and 24 Months Post-treatment: Bone Metabolism Sub-study
Ramy czasowe: Baseline, 6, 12, 24 months after randomization (on-treatment), 24 months post-treatment
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BMD measurements for Lumbar spine (LS) and Proximal Femur (Total Hip [TH]) were performed using dual energy X-ray absorptiometry (DXA) for participants who entered the bone-metabolism sub-study.
'N' (number of participants analyzed) signifies those participants who were evaluable for this outcome measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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Baseline, 6, 12, 24 months after randomization (on-treatment), 24 months post-treatment
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Percent Change From Baseline in Femoral Neck and Femoral Wards Bone Mineral Density (BMD) at 6, 12 and 24 Months On-treatment and 24 Months Post-treatment: Bone Metabolism Sub-study
Ramy czasowe: Baseline, 6, 12, 24 months after randomization (on-treatment), 24 months post-treatment
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BMD measurements for femoral neck (FN) and femoral wards (FW) were performed using dual energy X-ray absorptiometry (DXA) for participants who entered the bone-metabolism sub-study.
'N' (number of participants analyzed) signifies those participants who were evaluable for this outcome measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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Baseline, 6, 12, 24 months after randomization (on-treatment), 24 months post-treatment
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Change From Baseline in Lumbar Spine and Proximal Femur (Total Hip) Bone Mineral Density (BMD) T-scores at 6, 12 and 24 Months On-treatment and 24 Months Post-treatment: Bone Metabolism Sub-study
Ramy czasowe: Baseline, 6, 12, 24 months after randomization (on-treatment), 24 months post-treatment
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BMD measurements for Lumbar spine (LS) and Proximal Femur (Total Hip [TH]) were performed using dual energy X-ray absorptiometry (DXA) for participants who entered the bone-metabolism sub-study.
Results were scored as T-score.
T-score indicated how many standard deviations higher or lower participant's value was when compared to the young normal reference mean.
Using the World Health Organization (WHO) criteria for osteoporosis, a T-score of greater than or equal to (>=)-1.0 was classified as normal, a T-score of greater than -2.5 to less than -1.0 as osteopenic, and a T-score less than or equal to (<=)-2.5 as osteoporotic.
Here 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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Baseline, 6, 12, 24 months after randomization (on-treatment), 24 months post-treatment
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Percentage of Bone Specific Alkaline Phosphatase (BAP) Serum Concentration Relative to Baseline: Bone Metabolism Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30 months after randomization (on-treatment), 36 months after randomization (end of treatment), 12, 24 months post-treatment
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Bone specific alkaline phosphatase (BAP) serum concentration analyzed using enzyme immuno assay (EIA) at post-baseline time points was expressed as percentage of baseline BAP serum concentration.
'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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Baseline, 3, 6, 9, 12, 18, 24, 30 months after randomization (on-treatment), 36 months after randomization (end of treatment), 12, 24 months post-treatment
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Percentage of C-Terminal Telopeptide (CTX) Serum Concentration Relative to Baseline: Bone Metabolism Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30 months after randomization (on-treatment), 36 months after randomization (end of treatment), 12, 24 months post-treatment
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C-terminal telopeptide (CTX) serum concentration analyzed using competitive enzyme-linked immunosorbent assay (ELISA) at post-baseline time points was expressed as percentage of baseline CTX serum concentration.
'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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Baseline, 3, 6, 9, 12, 18, 24, 30 months after randomization (on-treatment), 36 months after randomization (end of treatment), 12, 24 months post-treatment
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Percentage of Osteocalcin (OC) and Procollagen T1 C-Peptide (PICP) Serum Concentration Relative to Baseline: Bone Metabolism Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30 months after randomization (on-treatment), 36 months after randomization (end of treatment), 12, 24 months post-treatment
|
Osteocalcin (OC) serum concentration analyzed using ELISA and procollagen T1 c-peptide (PICP) serum concentration analyzed using sandwich EIA at post-baseline time points was expressed as percentage of baseline OC serum concentration and baseline PICP serum concentration, respectively.
'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points, for each group respectively.
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Baseline, 3, 6, 9, 12, 18, 24, 30 months after randomization (on-treatment), 36 months after randomization (end of treatment), 12, 24 months post-treatment
|
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Percentage of Deoxy-pyridinoline (DPD) Urine Concentration Relative to Baseline: Bone Metabolism Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30 months after randomization (on-treatment), 36 months after randomization (end of treatment), 12, 24 months post-treatment
|
Deoxy-pyridinoline (DPD) urine concentration (adjusted for urinary creatinine) analyzed using competitive EIA at post-baseline time points was expressed as percentage of baseline DPD urine concentration.
'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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Baseline, 3, 6, 9, 12, 18, 24, 30 months after randomization (on-treatment), 36 months after randomization (end of treatment), 12, 24 months post-treatment
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Percentage of N-telopeptide of Type 1 Collagen (NTX) Urine Concentration Relative to Baseline: Bone Metabolism Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30 months after randomization (on-treatment), 36 months after randomization (end of treatment), 12, 24 months post-treatment
|
N-telopeptide of Type 1 collagen (NTX) urine concentration (adjusted for urinary creatinine) analyzed using competitive inhibition EIA at post-baseline time points was expressed as percentage of baseline NTX urine concentration.
'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
|
Baseline, 3, 6, 9, 12, 18, 24, 30 months after randomization (on-treatment), 36 months after randomization (end of treatment), 12, 24 months post-treatment
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Number of Participants With Fracture: Bone Metabolism Sub-study
Ramy czasowe: Baseline up to 24 months post-treatment
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Baseline up to 24 months post-treatment
|
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Change From Baseline in Treatment Outcome Index (TOI) at 3, 6, 9, 12, 18, 24, 30, 36, 48 and 60 Months: QoL Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
|
The TOI was defined as the sum of 23 items based on following Functional Assessment of Cancer Therapy - Breast version [FACT-B] subscales: Physical well-being (7 items), Functional well-being (7 items), Breast cancer subscale (9 items).
Each item was scaled from 0='Not at all' to 4='Very much'.
Total TOI score ranged from 0 to 92, where higher TOI score indicated better health-related quality of life (QoL).
A change of five points in the TOI scores was considered clinically meaningful.
'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
Results for 30, 36, 48, 60 months were not reported because data for these time points was only summarized as graphical presentation.
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Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
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Change From Baseline in Functional Assessment of Cancer Therapy - Endocrine Subscale (FACT-ES) Total Score at 3, 6, 9, 12, 18, 24, 30, 36, 48 and 60 Months: QoL Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
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The FACT-ES assessed health-related QoL in participants with breast cancer.
ES subscale comprised of 18 items (hot flushes,cold sweats,night sweats, vaginal discharge,vaginal irritation,vaginal bleeding,vaginal dryness,discomfort with intercourse,lost interest in sex,gained weight,light headed/dizzy,vomiting,had diarrhea,headaches,felt bloated,breast tenderness,mood swings, felt irritable).Participants indicated how true a statement was for them using a 5-point scale from 0 (not at all) to 4 (very much).
For items that were negatively framed, the scores were reversed for the analysis so that higher scores equated to a good QoL.
Total FACT-ES score was calculated as sum of all the 18 items and ranged from 0 to 72, where higher score indicated better QoL.
'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
|
Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
|
|
Change From Baseline in Total Functional Assessment of Cancer Therapy - General Breast and Endocrine (FACT-GBE) Score at 3, 6, 9, 12, 18, 24, 30, 36, 48 and 60 Months: QoL Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
|
FACT-GBE assessed health-related quality of life (QoL) in participants with breast cancer.
It consisted of 56 items,summarized to 7 subscales(subscale 1 to 6 constituted total FACT-B and subscale 7 constituted total ES):physical well-being(7 items), social/family well-being(7 items),relationship with doctor (2 items),emotional well-being(6 items),functional well-being(7 items),breast cancer subscale(9 items),endocrine symptoms(18 items).
Participants indicated how true a statement had been for them using 5-point scale from 0(not at all) to 4(very much).
For items that were negatively framed,scores were reversed for analysis so that higher scores equated to good QoL.
Total FACT-GBE score=sum of all 56 items(range 0 to 224, where higher score indicated better QoL.
'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
|
Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
|
|
Change From Baseline in Physical Well-Being (PWB) Subscale Score at 3, 6, 9, 12, 18, 24, 30, 36, 48 and 60 Months: QoL Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
|
The PWB subscale assessed physical well-being related QoL in participants with breast cancer.
PWB subscale comprised of 7 items (energy lack, nausea, family needs, pain, side effects, felt ill, forced to stay in bed).
Participants indicated how true a statement had been for them using a 5-point scale from 0 (not at all) to 4 (very much).
For items that were negatively framed, the scores were reversed for the analysis so that higher scores equated to a good QoL.
Total PWB score was calculated as the sum of all the 7 items and ranged from 0 to 28, where higher score indicated better physical well-being related QoL. 'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
|
Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
|
|
Change From Baseline in Social/Family Well-Being (SWB) Sub-scale Score at 3, 6, 9, 12, 18, 24, 30, 36, 48 and 60 Months: QoL Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
|
The SWB subscale assessed social/family well-being related QoL in participants with breast cancer.
SWB subscale comprised of 7 items (distant from friends, emotional support, support from friends, family acceptance, family communication, close to main support, sexual satisfaction).
Participants indicated how true a statement had been for them using a 5-point scale from 0 (not at all) to 4 (very much).
For items that were negatively framed, the scores were reversed for the analysis so that higher scores equated to a good QoL.
Total SWB score was calculated as the sum of all the 7 items and ranged from 0 to 28, where higher score indicated better social/family well-being related QoL. 'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
|
Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
|
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Change From Baseline in Relationship With Doctor (RWD) Subscale Score at 3, 6, 9, 12, 18, 24, 30, 36, 48 and 60 Months: QoL Substudy
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
|
The RWD subscale assessed relationship with doctor in participants with breast cancer.
RWD subscale comprised of 2 items (confidence in doctors, doctor answered questions).
Participants indicated how true a statement had been for them using a 5-point scale from 0 (not at all) to 4 (very much).
Total RWD score was calculated as the sum of the 2 items and ranged from 0 to 8, where higher score indicated better relationship with doctor.
'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
|
Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
|
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Change From Baseline in Emotional Well-Being (EWB) Subscale Score at 3, 6, 9, 12, 18, 24, 30, 36, 48 and 60 Months: QoL Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
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The EWB subscale assessed emotional well-being related QoL in participants with breast cancer.
EWB subscale comprised of 6 items (felt sad, proud of coping, lost hope, felt nervous, worried about dying, worried about condition worsening).
Participants indicated how true a statement had been for them using a 5-point scale from 0 (not at all) to 4 (very much).
For items that were negatively framed, the scores were reversed for the analysis so that higher scores equate to a good QoL.
Total EWB score was calculated as the sum of the 6 items and ranged from 0 to 24, where higher score indicated better emotional well-being related QoL. 'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
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Change From Baseline in Functional Well-Being (FWB) Sub-scale Score at 3, 6, 9, 12, 18, 24, 30, 36, 48 and 60 Months: QoL Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
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The FWB subscale assessed functional well-being related QoL in participants with breast cancer.
FWB subscale comprised of 7 items (able to work, work fulfilled, able to enjoy life, acceptance of illness, sleeping well, enjoyed normal fun activities, contented with QoL).
Participants indicated how true a statement had been for them using a 5-point scale from 0 (not at all) to 4 (very much).
Total FWB score was calculated as the sum of the 7 items and ranged from 0 to 28, where higher score indicated better functional well-being related QoL. 'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
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Change From Baseline in Breast Cancer Subscale (BCS) Score at 3, 6, 9, 12, 18, 24, 30, 36, 48 and 60 Months: QoL Sub-study
Ramy czasowe: Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
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The BCS subscale assessed health related QoL in participants with breast cancer.
BCS subscale comprised of 9 items (short of breath, self-conscious dress, tender/swollen arms, sexually attractive, bothered by hair loss, worried about familial risk, worried about family stress, bothered by weight change, able to feel like a woman).
Participants indicated how true a statement had been for them using a 5-point scale from 0 (not at all) to 4 (very much).
For items that were negatively framed, the scores were reversed for the analysis so that higher scores equated to a good QoL.
Total BCS score was calculated as the sum of the 9 items and ranged from 0 to 36, where higher score indicated better QoL.
'N' (number of participants analyzed) signifies those participants who were evaluable for this measure and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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Baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48, 60 months after randomization
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Number of Participants With Severe Endocrine Symptoms: QoL Sub-study
Ramy czasowe: Baseline up to 24 months after randomization
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Participants indicated prevalence of an endocrine subscale items using a 5-point scale, where 0 (not at all), 1 (a little bit), 2 (somewhat), 3 (quite a bit), 4 (very much).
Endocrine items were grouped in five categories vasomotor (hot flushes, cold sweats, night sweats, sleeping difficulties), neuropsychological (lack of energy, nervous feeling, lightheaded/dizzy, headaches, mood swings, feeling irritable), gastrointestinal symptoms (nausea, gained weight, vomiting, diarrhea, bloated feeling), gynecological symptoms (vaginal discharge, vaginal irritation, vaginal bleeding, vaginal dryness, discomfort with intercourse, lost interest in sex, breast tenderness) and other symptoms (pain, feeling ill, side effects).
Number of participants who reported severe endocrine symptoms (defined as response categories "quite a bit" and "very much") were presented.
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Baseline up to 24 months after randomization
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Percentage of Participants With Endometrial Thickness Greater Than or Equal to (>=) 5 Millimeter (mm): Endometrial Sub-study
Ramy czasowe: 6, 12, 24, 36 months after randomization, 6, 12, 24 months post-treatment
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Endometrial thickness was assessed using transvaginal ultrasound examination.
'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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6, 12, 24, 36 months after randomization, 6, 12, 24 months post-treatment
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Endometrial Thickness: Endometrial Sub-study
Ramy czasowe: Baseline, 6, 12, 24, 36 months after randomization, 6, 12, 24 months post-treatment
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Endometrial thickness was assessed using transvaginal ultrasound examination.
'N' (number of participants analyzed) signifies those participants who were evaluable for this outcome and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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Baseline, 6, 12, 24, 36 months after randomization, 6, 12, 24 months post-treatment
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Uterine and Overall Ovary Volume: Endometrial Sub-study
Ramy czasowe: 6, 12, 24, 36 months after randomization, 6, 12, 24 months post-treatment
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Uterine volume (UV) and ovarian volume was estimated using ultrasonography.
Uterine volume = (longitudinal diameter * transverse diameter * anteroposterior diameter of uterus)/(2*1000).
Ovary volume = [(longitudinal diameter * transverse diameter * anteroposterior diameter of ovary) * 3.14]/(6*1000).
Overall ovary volume (OV) is calculated as the sum of the right and left ovary volume.
'N' (number of participants analyzed) signifies those participants who were evaluable for this outcome and 'n' signifies those participants who were evaluable for this measure at given time points for each group, respectively.
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6, 12, 24, 36 months after randomization, 6, 12, 24 months post-treatment
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Number of Participants With Polyps, Fibroids and Ovarian Cysts: Endometrial Sub-study
Ramy czasowe: 6, 12, 24, 36 months after randomization, 6, 12, 24 months post-treatment
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Number of participants with presence of polyps (POL) and fibroids (FIB) at post-baseline time points compared to the baseline (BL) status of 'yes', 'no' or 'missing' (that is, participants reporting POL/FIB at post-baseline time points who had yes, no or missing POL/FIB status at baseline, respectively) were presented.
Result for number of participants with ovarian cysts was not analyzed at post-baseline time points as very few participants reported ovarian cysts at baseline.
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6, 12, 24, 36 months after randomization, 6, 12, 24 months post-treatment
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Percentage of Participants With at Least 1 Gynecological Symptoms: Endometrial Sub-study
Ramy czasowe: Baseline up to 24 months post-treatment
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Gynecological symptoms included bleeding/spotting, pelvic pain, leucorrhoea and vaginal itching.
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Baseline up to 24 months post-treatment
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Number of Participants With Histological Findings: Endometrial Sub-study
Ramy czasowe: Baseline up to 24 months post-treatment
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Baseline up to 24 months post-treatment
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Współpracownicy i badacze
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Publikacje i pomocne linki
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Daty zapisu na studia
Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.
Główne daty studiów
Rozpoczęcie studiów
1 lutego 1998
Zakończenie podstawowe (Rzeczywisty)
1 czerwca 2003
Ukończenie studiów (Rzeczywisty)
1 marca 2013
Daty rejestracji na studia
Pierwszy przesłany
31 maja 2002
Pierwszy przesłany, który spełnia kryteria kontroli jakości
31 maja 2002
Pierwszy wysłany (Oszacować)
3 czerwca 2002
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Oszacować)
7 maja 2014
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
21 kwietnia 2014
Ostatnia weryfikacja
1 kwietnia 2014
Więcej informacji
Terminy związane z tym badaniem
Dodatkowe istotne warunki MeSH
- Choroby skórne
- Nowotwory
- Nowotwory według lokalizacji
- Choroby piersi
- Nowotwory piersi
- Fizjologiczne skutki leków
- Molekularne mechanizmy działania farmakologicznego
- Inhibitory enzymów
- Środki przeciwnowotworowe
- Hormony, substytuty hormonów i antagoniści hormonów
- Środki przeciwnowotworowe, hormonalne
- Antagoniści hormonów
- Środki konserwujące gęstość kości
- Inhibitory aromatazy
- Inhibitory syntezy sterydów
- Antagoniści estrogenu
- Selektywne modulatory receptora estrogenowego
- Modulatory receptora estrogenowego
- Tamoksyfen
- Eksemestan
Inne numery identyfikacyjne badania
- 96-OEXE-031
- A5991012
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