A Study Comparing Duloxetine to Other Antidepressants in the Treatment of Severe Depression (TRY FIRST)
12 maja 2010 zaktualizowane przez: Eli Lilly and Company
TRY FIRST: A 12-Week, Randomized, Open-Label Trial of Duloxetine Versus Generic SSRIs in the Treatment of a Severe Depressive Episode
The purpose of this study is to compare duloxetine with other antidepressants in the treatment of severe depression.
Przegląd badań
Status
Zakończony
Warunki
Interwencja / Leczenie
Typ studiów
Interwencyjne
Zapisy (Rzeczywisty)
750
Faza
- Faza 4
Kontakty i lokalizacje
Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.
Lokalizacje studiów
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California
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Carson, California, Stany Zjednoczone, 90746
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Irvine, California, Stany Zjednoczone, 92618
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San Diego, California, Stany Zjednoczone, 92108
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Sherman Oaks, California, Stany Zjednoczone, 91403
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Torrance, California, Stany Zjednoczone, 90502
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Colorado
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Pueblo, Colorado, Stany Zjednoczone, 81008
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Florida
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Clearwater, Florida, Stany Zjednoczone, 33765
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Coral Springs, Florida, Stany Zjednoczone, 33065
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Deerfield Beach, Florida, Stany Zjednoczone, 33064
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Fort Myers, Florida, Stany Zjednoczone, 33912
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Gainesville, Florida, Stany Zjednoczone, 32607
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Hialeah, Florida, Stany Zjednoczone, 33016
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Melbourne, Florida, Stany Zjednoczone, 32901
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Miami, Florida, Stany Zjednoczone, 33173
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Winter Park, Florida, Stany Zjednoczone, 32789
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Georgia
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Atlanta, Georgia, Stany Zjednoczone, 30338
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Illinois
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Joliet, Illinois, Stany Zjednoczone, 60435
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Oak Brook, Illinois, Stany Zjednoczone, 60523
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Park Ridge, Illinois, Stany Zjednoczone, 60068
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Indiana
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Greenwood, Indiana, Stany Zjednoczone, 46143
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Terre Haute, Indiana, Stany Zjednoczone, 47802
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Kansas
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Prairie Village, Kansas, Stany Zjednoczone, 66206
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Wichita, Kansas, Stany Zjednoczone, 67203
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Maryland
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Gaithersburg, Maryland, Stany Zjednoczone, 20877
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Glen Burnie, Maryland, Stany Zjednoczone, 21061
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Rockville, Maryland, Stany Zjednoczone, 20852
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Massachusetts
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Fall River, Massachusetts, Stany Zjednoczone, 02721
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Missouri
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St Louis, Missouri, Stany Zjednoczone, 63141
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New Jersey
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Clementon, New Jersey, Stany Zjednoczone, 08021
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Princeton, New Jersey, Stany Zjednoczone, 08540
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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New York
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Brooklyn, New York, Stany Zjednoczone, 11223
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Fresh Meadows, New York, Stany Zjednoczone, 11366
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Mount Kisco, New York, Stany Zjednoczone, 10549
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Rochester, New York, Stany Zjednoczone, 14618
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Staten Island, New York, Stany Zjednoczone, 10312
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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North Carolina
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Concord, North Carolina, Stany Zjednoczone, 28025
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Durham, North Carolina, Stany Zjednoczone, 27707
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Ohio
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Beachwood, Ohio, Stany Zjednoczone, 44122
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Dayton, Ohio, Stany Zjednoczone, 45432
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Kettering, Ohio, Stany Zjednoczone, 45429
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Oklahoma
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Oklahoma City, Oklahoma, Stany Zjednoczone, 73119
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Oregon
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Eugene, Oregon, Stany Zjednoczone, 97404
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Pennsylvania
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Havertown, Pennsylvania, Stany Zjednoczone, 19083
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Media, Pennsylvania, Stany Zjednoczone, 19063
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Newtown, Pennsylvania, Stany Zjednoczone, 18940
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Philadelphia, Pennsylvania, Stany Zjednoczone, 19139
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Rhode Island
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Lincoln, Rhode Island, Stany Zjednoczone, 02865
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South Carolina
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Columbia, South Carolina, Stany Zjednoczone, 29201
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South Dakota
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Sioux Falls, South Dakota, Stany Zjednoczone, 57105
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Texas
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Austin, Texas, Stany Zjednoczone, 78756
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Dallas, Texas, Stany Zjednoczone, 75231
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Friendswood, Texas, Stany Zjednoczone, 77546
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Houston, Texas, Stany Zjednoczone, 77074
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Lake Jackson, Texas, Stany Zjednoczone, 77566
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San Antonio, Texas, Stany Zjednoczone, 78229
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Wichita Falls, Texas, Stany Zjednoczone, 76309
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Vermont
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Woodstock, Vermont, Stany Zjednoczone, 05091
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Virginia
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Charlottesville, Virginia, Stany Zjednoczone, 22903
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Herndon, Virginia, Stany Zjednoczone, 20170
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Washington
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Bellevue, Washington, Stany Zjednoczone, 98004
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Wisconsin
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Brown Deer, Wisconsin, Stany Zjednoczone, 53223
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Kryteria uczestnictwa
Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.
Kryteria kwalifikacji
Wiek uprawniający do nauki
18 lat i starsze (Dorosły, Starszy dorosły)
Akceptuje zdrowych ochotników
Nie
Płeć kwalifikująca się do nauki
Wszystko
Opis
Inclusion criteria:
- At least 18 years of age
- Have major depression and are currently in a severe depressive episode
- Have a degree of understanding such that patient can communicate with the investigator and study staff
- All females must test negative for pregnancy
- Females of childbearing potential must use reliable method of birth control during the study and for 1 month after taking the last dose of study drug
Exclusion criteria:
- Have not responded to duloxetine for depression in the past
- Have a history of bipolar disorder, a psychotic disorder (such as schizophrenia), a cognitive disorder (such as moderate or severe dementia), or obsessive-compulsive disorder (OCD)
- Are at significant risk for suicide
- Have not responded to 2 or more adequate trials of antidepressant medications during the current depressive episode
- Have a serious, unstable medical condition
- Have a current or recent history of substance abuse or dependence
- Have had electroconvulsive therapy (ECT), transcranial magnetic stimulation (rTMS), or vagus nerve stimulation (VNS) in the past year
- Have started psychotherapy within 6 weeks prior to study entry
- Have a serious medical illness or clinically significant laboratory abnormality that is not stabilized or is anticipated, in the judgment of the investigator, to require hospitalization or use of an excluded medication during the course of the study
Plan studiów
Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.
Jak projektuje się badanie?
Szczegóły projektu
- Główny cel: Leczenie
- Przydział: Randomizowane
- Model interwencyjny: Przydział równoległy
- Maskowanie: Brak (otwarta etykieta)
Broń i interwencje
Grupa uczestników / Arm |
Interwencja / Leczenie |
|---|---|
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Aktywny komparator: paroksetyna
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20-50 mgs orally daily for 12 weeks
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Aktywny komparator: fluoksetyna
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20-80 mgs orally daily for 12 weeks
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Eksperymentalny: duloxetine
study drug
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30-120 milligrams (mgs) orally daily for 12 weeks
Inne nazwy:
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Aktywny komparator: citalopram
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20-40 mgs orally daily for 12 weeks
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Aktywny komparator: sertraline
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50-200 mgs orally daily for 12 weeks
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Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
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Probability of Remission [16-item Quick Inventory of Depressive Symptomatology (QIDS-SR) Score Less Than or Equal to 5 at 12-Week Endpoint]
Ramy czasowe: 12 weeks
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Visitwise probability of participants per treatment meeting remission criteria (QIDS-SR total score [TS]</=5 at week 12 endpoint) were estimated using a pseudolikelihood-based mixed-models repeated measures analysis for a categorical outcome, model included fixed, categorical effects of treatment group (duloxetine vs. SSRIs), visit, treatment group-by-visit & continuous, fixed covariate of baseline QIDS-SR TS, and random effect of participant.
Primary analysis contrasted remission probability at week 12 endpoint between treatment groups.
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12 weeks
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Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
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Change From Baseline in QIDS-SR Total Score at 12-Week Endpoint (Mood Measure)
Ramy czasowe: Baseline, 12 weeks
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The QIDS-SR is a 16-item, participant-rated short form of the Inventory of Depressive Symptomatology that assesses 9 domains: sad mood, concentration, self-outlook, suicidal ideation, involvement, energy/fatigability, sleep disturbance, appetite/weight increase/decrease and psychomotor agitation/retardation.
Scores range from 0 (none) to 27 (very severe).
The QIDS-SR total score was used to derive the mean change from baseline to endpoint depression.
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Baseline, 12 weeks
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Probability of Remission [17-item Hamilton Depression Rating Scale (HAMD-17) (Mood Measure) Less Than or Equal to 7 at 12-Week Endpoint]
Ramy czasowe: 12 weeks
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Visitwise percentages of participants meeting remission criteria HAMD-17 total score [TS] </=7 at week 12 endpoint) were estimated using a categorical, pseudolike-lihood-based repeated measures approach, & included fixed, categorical effects of treatment group (duloxetine vs. SSRIs), visit, treatment group-by-visit interaction, & continuous, fixed covariate of baseline HAMD-17 TS.
Primary analysis will be contrast of remission rates at week 12 endpoint between treatment groups, & represents estimated remission rates for each treatment group had all participants completed 12 weeks of therapy.
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12 weeks
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Probability of Response [QIDS-SR Total Score (Mood Measure) Greater Than Or Equal To 50 Percent Reduction From Baseline To 12 Week Endpoint]
Ramy czasowe: Baseline, 12-Weeks
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Visitwise percentages of participants meeting response criteria (50% reduction from baseline QIDS-SR total score at 12-week endpoint) were estimated using a categorical, pseudolikelihood-based repeated measures approach, & included fixed, categorical effects of treatment group, visit, treatment group-by-visit interaction, & continuous, fixed covariate of baseline QIDS-SR.
The primary analysis will be the contrast of response rates at week 12 endpoint between treatment groups, and represents estimated response rates for each treatment group had all participants completed 12 weeks of therapy.
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Baseline, 12-Weeks
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Probability of Response [HAMD-17 Total Score (Mood Measure) Greater Than Or Equal To 50 Percent Reduction From Baseline To 12 Week Endpoint]
Ramy czasowe: Baseline, 12-Weeks
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Visitwise percentages of participants meeting response criteria 50% reduction from baseline in HAMD-17 total score at 12-Week endpoint) were estimated using a categorical, pseudolike-lihood-based repeated measures approach, & included fixed, categorical effects of treatment group, visit, treatment group-by-visit interaction, & continuous, fixed covariate of baseline HAMD-17 TS.
Primary analysis will be the contrast of response rates at week 12 endpoint between treatment groups, & represents estimated response rates for each treatment group had all participants completed 12 weeks of therapy.
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Baseline, 12-Weeks
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Change From Baseline in HAMD-17 Total Score at 12-Week Endpoint (Mood Measure)
Ramy czasowe: Baseline, 12 Weeks
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The HAMD-17 is a rater-administered assessment of depression severity and improvement, with total score ranges from 0 (not at all depressed) to 52 (most severely depressed).
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Baseline, 12 Weeks
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Change From Baseline in HAMD-17 Anxiety/Somatization Subscale Score at 12-Week Endpoint (Mood Measure)
Ramy czasowe: Baseline, 12 Weeks
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HAMD-17 subscale consists of items 10, 11, 12, 13, 15, and 17 evaluates agitation, and severity of psychic and somatic manifestations of anxiety.
Total subscale scores range from 0 (normal) to 18 (severe).
Mean change from baseline to endpoint.
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Baseline, 12 Weeks
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Change From Baseline in HAMD-17 Maier Subscale Score at 12-Week Endpoint (Mood Measure)
Ramy czasowe: Baseline, 12 weeks
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HAMD-17 Maier Subscale consists of Items 1, 2, 7, 8, 9, 10 and represents the "core" symptoms of depression.
Total subscale scores range from 0 (normal) to 24 (severe).
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Baseline, 12 weeks
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Change From Baseline in HAMD-17 Bech Subscale Score at 12-Week Endpoint (Mood Measure)
Ramy czasowe: Baseline, 12 Weeks
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HAMD-17 Bech subscale consists of items 1, 2, 7, 8, 10, and 13 used to evaluate core symptoms of Major Depressive Disorder (MDD).
Total subscale scores range from 0 (normal) to 22 (severe).
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Baseline, 12 Weeks
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Change From Baseline in HAMD-17 Retardation Subscale Score at 12-Week Endpoint (Mood Measure)
Ramy czasowe: Baseline, 12 Weeks
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The HAMD-17 Retardation subscale consists of Items 1, 7, 8, 14 and evaluates dysfunction in mood, work, and sexual activity, as well as overall motor retardation.
Total subscale scores range from 0 (normal) to 14 (severe).
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Baseline, 12 Weeks
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Change From Baseline in HAMD-17 Sleep Subscale Score at 12-Week Endpoint (Mood Measure)
Ramy czasowe: Baseline, 12 Weeks
|
The HAMD-17 Sleep Subscale consists of Items 4, 5, 6 and evaluates initial, middle, and late insomnia.
Total subscale scores range from 0 (no difficulty) to 6 (difficulty).
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Baseline, 12 Weeks
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Change From Baseline in Brief Pain Inventory (BPI) Average 24-hour Pain Score, in Particpants With a Baseline BPI Average 24-hour Pain Score of 3 or Greater, at 12-Week Endpoint (Pain Measure)
Ramy czasowe: Baseline, 12 Weeks
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The BPI is a self-reported scale measuring pain severity and pain-specific interference on function on a scale ranging from 0 (no pain) to 10 (pain as bad as you can imagine).
The BPI average 24-hour pain measure was used to derive the overall mean change from baseline to endpoint, in those participants who had a BPI average 24-hour pain score of 3 or greater at baseline.
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Baseline, 12 Weeks
|
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Change From Baseline in BPI Average 24 Hour Pain Score at 12-Week Endpoint (Pain Measure)
Ramy czasowe: Baseline, 12 weeks
|
The BPI is a self-reported scale measuring pain severity and pain-specific interference on function, with scores ranging from 0 (does not interfere) to 10 (completely interferes).
The BPI average 24-hour pain measure was used to derive the overall mean change from baseline to endpoint.
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Baseline, 12 weeks
|
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Change From Baseline in Sheehan Disability Scale (SDS) Global Functional Impairment Score at 12-Week Endpoint (Functional Outcome Measure)
Ramy czasowe: Baseline, 12 weeks
|
The SDS is a participant-rated anchored visual analog scale to assess disability across the three domains of work/school, social life, and family life, with each item scored from 0 (not at all) to 10 (very severely), with a summarization of the 3 items to evaluate global functioning.
The Global Functional Impairment Score is a total score score that ranges from 0 (unimpaired) to 30 (highly impaired), and was used to derived the mean change from baseline to endpoint.
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Baseline, 12 weeks
|
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Change From Baseline in SDS Work/School Item Score at 12-Week Endpoint (Functional Outcome Measure)
Ramy czasowe: Baseline, 12 Weeks
|
The SDS is completed by the participant and Item 1 is used to assess the effect of the participant's symptoms on their work/school schedule.
Scores range from 0 to 10 with higher values indicating greater disruption in the participant's work/school life.
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Baseline, 12 Weeks
|
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Change From Baseline in Sheehan Disability Scale (SDS) Family/Home Item Score at Week-12 Endpoint (Functional Outcome Measure)
Ramy czasowe: Baseline, 12 Weeks
|
The SDS is completed by the participant and Item 3 is used to assess the effect of the participant's symptoms on their family life/home responsibilities.
Scores range from 0 to 10 with higher values indicating greater disruption in the participant's family life/home responsibilities.
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Baseline, 12 Weeks
|
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Change From Baseline in SDS Social Item Score at 12-Week Endpoint (Functional Outcome Measure)
Ramy czasowe: Baseline, 12 Weeks
|
The SDS is completed by the participant and is used to assess the effect of the participant's symptoms on their work/social/family life.
Total scores range from 0 to 30 with higher values indicating greater disruption in the participant's work/social/family life.
|
Baseline, 12 Weeks
|
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Change From Baseline in Systolic Blood Pressure at Week-12 Endpoint
Ramy czasowe: Baseline, 12 Weeks
|
Mean change from baseline to endpoint in systolic blood pressure
|
Baseline, 12 Weeks
|
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Change From Baseline in Diastolic Blood Pressure at Week-12 Endpoint
Ramy czasowe: Baseline, 12 Weeks
|
Mean change from baseline to endpoint in diastolic blood pressure
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Baseline, 12 Weeks
|
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Change From Baseline in Pulse Rate at Week-12 Endpoint
Ramy czasowe: Baseline, 12 Weeks
|
Mean change from baseline to endpoint in pulse rate
|
Baseline, 12 Weeks
|
|
Change From Baseline in Weight at Week-12 Endpoint
Ramy czasowe: Baseline, 12 Weeks
|
Mean change from baseline to endpoint in weight
|
Baseline, 12 Weeks
|
Inne miary wyników
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Change From Baseline in World Health Organization Health and Work Performance Questionnaire, Clinical Trials 7-Day Version (HPQ), Dollars of Income Lost Due to Work Presenteeism (WP)Score, at Week-12 Endpoint
Ramy czasowe: Baseline, 12 Weeks
|
WP score was calculated by taking midpoint of annual before-tax income reported on HPQ.
A multiplier of 1.25 produced estimated direct & indirect (i.e.
benefits) income.
Annual hours expected to work were calculated from expected daily work hours, multiplied by 236 days.
Hourly, indirect income was total direct + indirect income, divided by # of expected annual work hours.
Indirect hours lost annually for WP=hours expected to be worked annually times WP percent, times hourly rate=dollars earned, and then subtracted from total direct + indirect income=dollars lost annually due to WP.
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Baseline, 12 Weeks
|
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Change From Baseline in World Health Organization Health and Work Performance Questionnaire, Clinical Trials 7-Day Version (HPQ), Dollars of Income Lost Due to Work Absenteeism Score at Week-12 Endpoint
Ramy czasowe: Baseline, 12 weeks
|
Self-administered assessment used to determine a participant's work performance in terms of employment status, absenteeism if employed, productivity while at work, usual occupation, and annual income.
Tool assesses the potential impact of change in depressive symptoms on work productivity and its associated employer costs.
Scale ranges from 0 to 100% of work days in past 30 days.
Absenteeism and presenteeism were combined into a measure of total lost work performance by adding absenteeism to the value ([100-absenteeism] × [100-presenteeism]).
Mean change baseline to endpoint.
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Baseline, 12 weeks
|
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Change From Baseline in World Health Organization Health and Work Performance Questionnaire, Clinical Trials 7-Day Version (HPQ), Absenteeism at 12-Week Endpoint
Ramy czasowe: Baseline, 12 Weeks
|
Self-administered assessment used to determine a subject's work performance in terms of employment status, absenteeism if employed, productivity while at work, usual occupation, and annual income.
Tool assesses the potential impact of change in depressive symptoms on work productivity and its associated employer costs.
Defined on a 0-100 scale for the percentage of work days the respondent missed in the past 30 days.
Absolute absenteeism: actual hours worked minus expected hours equals number of missed work days.
Mean change baseline to endpoint is reported.
|
Baseline, 12 Weeks
|
|
Change From Baseline in World Health Organization Health and Work Performance Questionnaire, Clinical Trials 7-Day Version (HPQ), Presenteeism Score, at Week-12 Endpoint
Ramy czasowe: Baseline, 12 Weeks
|
Self-administered assessment used to determine a participant's work performance (employment status, absenteeism if employed, productivity while at work, usual occupation, & annual income).
Tool assesses the potential impact of change in depressive symptoms on work productivity & its associated employer costs using a 0-100 scale in which 0 meant doing no work at all on days spent at work and 100 meant performing at the level of a top worker.
Absolute presenteeism: difference between "score for self" and "score for average worker in same job".
Mean change baseline to endpoint is reported.
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Baseline, 12 Weeks
|
Współpracownicy i badacze
Tutaj znajdziesz osoby i organizacje zaangażowane w to badanie.
Sponsor
Współpracownicy
Śledczy
- Dyrektor Studium: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon-Fri 9AM - 5PM Eastern Time (UTC/GMT-5 hours, EST), Eli Lilly and Company
Publikacje i pomocne linki
Osoba odpowiedzialna za wprowadzenie informacji o badaniu dobrowolnie udostępnia te publikacje. Mogą one dotyczyć wszystkiego, co jest związane z badaniem.
Publikacje ogólne
- Dodd S, Berk M, Kelin K, Zhang Q, Eriksson E, Deberdt W, Craig Nelson J. Application of the Gradient Boosted method in randomised clinical trials: Participant variables that contribute to depression treatment efficacy of duloxetine, SSRIs or placebo. J Affect Disord. 2014 Oct;168:284-93. doi: 10.1016/j.jad.2014.05.014. Epub 2014 Jun 4.
- Martinez JM, Katon W, Greist JH, Kroenke K, Thase ME, Meyers AL, Edwards SE, Marangell LB, Shoemaker S, Swindle R. A pragmatic 12-week, randomized trial of duloxetine versus generic selective serotonin-reuptake inhibitors in the treatment of adult outpatients in a moderate-to-severe depressive episode. Int Clin Psychopharmacol. 2012 Jan;27(1):17-26. doi: 10.1097/YIC.0b013e32834ce11b.
Daty zapisu na studia
Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.
Główne daty studiów
Rozpoczęcie studiów
1 maja 2008
Zakończenie podstawowe (Rzeczywisty)
1 lutego 2009
Ukończenie studiów (Rzeczywisty)
1 marca 2009
Daty rejestracji na studia
Pierwszy przesłany
23 kwietnia 2008
Pierwszy przesłany, który spełnia kryteria kontroli jakości
24 kwietnia 2008
Pierwszy wysłany (Oszacować)
25 kwietnia 2008
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Oszacować)
15 czerwca 2010
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
12 maja 2010
Ostatnia weryfikacja
1 maja 2010
Więcej informacji
Terminy związane z tym badaniem
Słowa kluczowe
Dodatkowe istotne warunki MeSH
- Objawy behawioralne
- Zaburzenia psychiczne
- Zaburzenia nastroju
- Depresja
- Zaburzenia depresyjne
- Fizjologiczne skutki leków
- Agentów neuroprzekaźników
- Molekularne mechanizmy działania farmakologicznego
- Agenty obwodowego układu nerwowego
- Inhibitory enzymów
- Środki przeciwbólowe
- Agenci systemu sensorycznego
- Leki psychotropowe
- Inhibitory wychwytu serotoniny
- Inhibitory wychwytu neuroprzekaźników
- Modulatory transportu membranowego
- Środki serotoninowe
- Środki przeciwdepresyjne
- Agentów dopaminy
- Inhibitory enzymów cytochromu P-450
- Środki przeciwdepresyjne drugiej generacji
- Inhibitory wychwytu zwrotnego serotoniny i noradrenaliny
- Inhibitory cytochromu P-450 CYP2D6
- Sertralina
- Chlorowodorek duloksetyny
- Citalopram
- Paroksetyna
- Fluoksetyna
Inne numery identyfikacyjne badania
- 11715 (DAIDS ES)
- F1J-US-HMFT (Inny identyfikator: Eli Lilly and Company)
Te informacje zostały pobrane bezpośrednio ze strony internetowej clinicaltrials.gov bez żadnych zmian. Jeśli chcesz zmienić, usunąć lub zaktualizować dane swojego badania, skontaktuj się z register@clinicaltrials.gov. Gdy tylko zmiana zostanie wprowadzona na stronie clinicaltrials.gov, zostanie ona automatycznie zaktualizowana również na naszej stronie internetowej .