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Badanie otwarte dla uczestników z reumatoidalnym zapaleniem stawów

11 maja 2018 zaktualizowane przez: Eli Lilly and Company

Wieloośrodkowe, otwarte badanie fazy 3b oceniające długoterminowe bezpieczeństwo i skuteczność LY2127399 u pacjentów z reumatoidalnym zapaleniem stawów (RZS)

Głównym celem tego badania jest pomoc w udzieleniu odpowiedzi, czy LY2127399 jest bezpieczny i skuteczny podczas długotrwałego leczenia uczestników z reumatoidalnym zapaleniem stawów.

Badanie to składa się z 2 okresów:

Okres 1: Leczenie bez zaślepienia przez okres do 240 tygodni dla uczestników, którzy zgłosili się z badania H9B-MC-BCDO (BCDO) (NCT01202760) lub H9B-MC-BCDV (BCDV) (NCT01202773) lub do 168 tygodni dla uczestników, którzy zgłosili się z Badanie H9B-MC-BCDM (BCDM) (NCT01198002).

Okres 2: 48-tygodniowa obserwacja po leczeniu

Przegląd badań

Status

Zakończony

Warunki

Reumatyzm

Interwencja / Leczenie

Lek: LY2127399

Szczegółowy opis

Osoby niereagujące na leczenie w 16. tygodniu (NR) to uczestnicy z <20% poprawą w stosunku do wartości początkowej zarówno liczby bolesnych, jak i obrzękniętych stawów, ocenianą w 16. tygodniu badań BCDO, BCDV i BCDM.

Typ studiów

Interwencyjne

Zapisy (Rzeczywisty)

1086

Faza

Faza 3

Kontakty i lokalizacje

Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.

Lokalizacje studiów

Afryka Południowa
- - Benoni, Afryka Południowa, 1500
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  - Bloemfontein, Afryka Południowa, 9301
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  - Breyten, Afryka Południowa, 2330
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  - Cape Town, Afryka Południowa, 7925
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  - Durban, Afryka Południowa, 4092
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  - Limpopo, Afryka Południowa, 0380
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  - Pretoria, Afryka Południowa, 0184
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  - Somerset West, Afryka Południowa, 7130
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  - Stellenbosch, Afryka Południowa, 7600
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Argentyna
- - Buenos Aires, Argentyna, C1280AEB
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  - Córdoba, Argentyna, X5016KEH
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  - Lujan, Argentyna, 6700
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  - Mar Del Plata, Argentyna, B7600FZN
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  - Quilmes, Argentyna, B1878DVC
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  - Rosario, Argentyna, 2000
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  - San Juan, Argentyna, 5400
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  - Tucuman, Argentyna, 4000
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Australia
- - Malvern East, Australia, 3145
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- New South Wales
  - Campbelltown, New South Wales, Australia, 2560
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  - Kogarah, New South Wales, Australia, 04266-010
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- Queensland
  - Herston, Queensland, Australia, 4029
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Brazylia
- - Campinas, Brazylia, 13059-000
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  - Caxias Do Sul, Brazylia, 95070-560
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  - Curitiba, Brazylia, 80060-240
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  - Fortaleza, Brazylia, 60150-170
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  - Juiz De Fora, Brazylia, 36010-570
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  - Rio De Janeiro, Brazylia, 20551-030
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  - Setor Oeste/Goiania, Brazylia, 74110-129
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  - São Paulo, Brazylia, 05403-000
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Bułgaria
- - Burgas, Bułgaria, 8000
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  - Pleven, Bułgaria, 5800
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  - Plovdiv, Bułgaria, 4003
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  - Rousse, Bułgaria, 7002
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  - Sevlievo, Bułgaria, 5400
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  - Sofia, Bułgaria, 1784
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  - Varna, Bułgaria, 9000
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Chorwacja
- - Opatija, Chorwacja, 51410
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  - Osijek, Chorwacja, 31000
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  - Rijeka, Chorwacja, HR-51000
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Federacja Rosyjska
- - Barnaul, Federacja Rosyjska, 656038
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  - Kazan, Federacja Rosyjska, 420029
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  - Kemerovo, Federacja Rosyjska, 650066
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  - Khanty-Mansiysk, Federacja Rosyjska, 628012
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  - Kursk, Federacja Rosyjska, 305007
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  - Moscow, Federacja Rosyjska, 125299
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  - Nizhny Novgorod, Federacja Rosyjska, 603005
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  - Novosibirsk, Federacja Rosyjska, 630047
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  - Petrozavodsk, Federacja Rosyjska, 185019
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  - Ryazan, Federacja Rosyjska, 390026
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  - Saint Petersburg, Federacja Rosyjska, 197022
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  - Saratov, Federacja Rosyjska, 410002
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  - Stavropol, Federacja Rosyjska, 355017
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  - Voronezh, Federacja Rosyjska, 394066
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  - Yaroslavl, Federacja Rosyjska, 150062
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Francja
- - Montpellier, Francja, 34295
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  - Nice, Francja, 06202
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  - Orleans, Francja, 45000
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  - Paris, Francja, 75022
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  - Saint-Etienne Cedex 02, Francja, 42055
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  - Strasbourg, Francja, 67 098
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  - Toulouse, Francja, 31059
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Grecja
- - Haidari/Athens, Grecja, 12462
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  - Heraklion, Grecja, 71110
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  - Larissa, Grecja, 411 10
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  - Thessaloniki, Grecja, 54636
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Hiszpania
- - Barcelona, Hiszpania, 08034
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  - Bilboa, Hiszpania, 48013
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  - La Coruña, Hiszpania, 15006
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  - Madrid, Hiszpania, 28046
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  - San Sebastian, Hiszpania, 20014
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Indie
- - Ahmedabad, Indie, 3800015
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  - Bangalore, Indie, 5600092
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  - Chennai, Indie, 600100
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  - Hyderabaad, Indie, 500082
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  - Jaipur, Indie, 302023
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  - Lucknow, Indie, 226 014
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  - Mysore, Indie, 570023
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  - Nellore, Indie, 524003
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  - New Delhi, Indie, 110 076
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  - Secunderabad, Indie, 500 003
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  - Surat, Indie, 395003
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Japonia
- - Aichi, Japonia, 460-0001
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  - Chiba, Japonia, 260-8712
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  - Fukuoka, Japonia, 807-8555
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  - Gunma, Japonia, 370-0053
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Hokkaido, Japonia, 063-0811
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Hyogo, Japonia, 650-0017
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Ibaragi, Japonia, 316-0035
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Ibaraki, Japonia, 305-8576
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Japan, Japonia, 275-0006
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Kagoshima, Japonia, 891-0133
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Kanagawa, Japonia, 252-0392
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Kumamoto, Japonia, 861-8520
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Mie, Japonia, 514-1101
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Miyagi, Japonia, 982-0032
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Miyazaki, Japonia, 880-0122
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Nagano, Japonia, 380-8582
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Nagasaki, Japonia, 857-1195
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Nara, Japonia, 634-0007
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Ohita, Japonia, 874-0011
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Okayama, Japonia, 710-0016
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Osaka, Japonia, 586-8521
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Saga, Japonia, 843-0393
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Saitama, Japonia, 337-0012
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Sapporo-Shi, Japonia, 060-8648
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Shizuoka, Japonia, 420-8623
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Tokushima, Japonia, 770-8503
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Tokyo, Japonia, 113-0034
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Toyama, Japonia, 933-0874
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Kolumbia
- - Bogota, Kolumbia
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Medellin, Kolumbia
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Litwa
- - Alytus, Litwa, 62114
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Kaunas, Litwa, 49475
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Klaipedos, Litwa, 92288
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Siauliai, Litwa, 73231
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Vilnius, Litwa, LT-08661
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Malezja
- - Batu Caves, Malezja, 68100
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Kota Bahru, Malezja, 15586
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Kuantan Pahang, Malezja, 25100
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Perak, Malezja, 30990
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Putrajaya, Malezja, 62250
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Sarawak, Malezja, 93586
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Meksyk
- - Aguascalientes, Meksyk, 20000
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Barrio San Mateo, Meksyk, 52140
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Chihuahua, Meksyk, 31000
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Guadalajara, Meksyk, 44690
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Mexicali, Meksyk, 21100
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Mexico City, Meksyk, 03720
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Monterrey, Meksyk, 64460
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Morelia, Meksyk, 58070
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Queretaro, Meksyk, 76000
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - San Luis Potosi, Meksyk, 78200
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Tijuana, Meksyk, 22010
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Niemcy
- - Bad Doberan, Niemcy, 18209
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Bad Nauheim, Niemcy, 61231
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Baden-Baden, Niemcy, 76530
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Berlin, Niemcy, 14059
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Dresden, Niemcy, 01307
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Erlangen, Niemcy, 91054
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Frankfurt, Niemcy, 60590
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Göttingen, Niemcy, 37075
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Koeln, Niemcy, 50924
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Munich, Niemcy, 80639
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Nowa Zelandia
- - Hamilton, Nowa Zelandia, 3204
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Rotorua, Nowa Zelandia, 3010
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Tauranga, Nowa Zelandia, 3140
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Timaru, Nowa Zelandia
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Polska
- - Bydgoszcz, Polska, 85-168
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Dzialdowo, Polska, 13-200
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Elblag, Polska, 82-300
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Gdynia, Polska, 81-384
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Krakow, Polska, 30-510
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Lublin, Polska, 20-607
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Plock, Polska, 09-400
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Torun, Polska, 87-100
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Warsaw, Polska, 01-192
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Wloszczowa, Polska, 29-100
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Republika Korei
- - Busan, Republika Korei, 602-715
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Daegu, Republika Korei, 700-721
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Daejeon, Republika Korei, 301-721
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Incheon, Republika Korei, 400-711
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Seongnam-Si, Republika Korei, 463-707
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Seoul, Republika Korei, 143-729
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Suwon-City, Republika Korei, 442-721
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Rumunia
- - Brasov, Rumunia, 500365
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Cluj-Napoca, Rumunia, 400130
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Iasi, Rumunia, 700656
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Ploiesti, Rumunia, 100337
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Sri Lanka
- - Colombo, Sri Lanka
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Galle, Sri Lanka
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Kalubowila, Sri Lanka
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Nugegoda, Sri Lanka
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Stany Zjednoczone
- Alabama
  - Birmingham, Alabama, Stany Zjednoczone, 35216
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Huntsville, Alabama, Stany Zjednoczone, 35810
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Arizona
  - Peoria, Arizona, Stany Zjednoczone, 85381
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Phoenix, Arizona, Stany Zjednoczone, 85032
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Scottsdale, Arizona, Stany Zjednoczone, 85251
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Tucson, Arizona, Stany Zjednoczone, 85704
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Arkansas
  - Hot Springs, Arkansas, Stany Zjednoczone, 71913
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Jonesboro, Arkansas, Stany Zjednoczone, 72401
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Little Rock, Arkansas, Stany Zjednoczone, 72205
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- California
  - Escondido, California, Stany Zjednoczone, 92027
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Fresno, California, Stany Zjednoczone, 93720
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Hemet, California, Stany Zjednoczone, 92543
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Huntington Beach, California, Stany Zjednoczone, 92646
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - La Jolla, California, Stany Zjednoczone, 92037
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - La Mesa, California, Stany Zjednoczone, 91942
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Loma Linda, California, Stany Zjednoczone, 92354
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Long Beach, California, Stany Zjednoczone, 90808
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Los Angeles, California, Stany Zjednoczone, 90022
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Sacramento, California, Stany Zjednoczone, 95825
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - San Diego, California, Stany Zjednoczone, 92108
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Santa Monica, California, Stany Zjednoczone, 90404
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Torrance, California, Stany Zjednoczone, 90505
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Tustin, California, Stany Zjednoczone, 92780
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Upland, California, Stany Zjednoczone, 91786
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Wildomar, California, Stany Zjednoczone, 92595
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Colorado
  - Colorado Springs, Colorado, Stany Zjednoczone, 80910
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Denver, Colorado, Stany Zjednoczone, 80209
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Delaware
  - Lewes, Delaware, Stany Zjednoczone, 19958
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Florida
  - Aventura, Florida, Stany Zjednoczone, 33180
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Boca Raton, Florida, Stany Zjednoczone, 33486
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Boynton Beach, Florida, Stany Zjednoczone, 33472
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - DeBary, Florida, Stany Zjednoczone, 32713
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Miami, Florida, Stany Zjednoczone, 33173
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - New Port Richey, Florida, Stany Zjednoczone, 34652
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Palm Harbor, Florida, Stany Zjednoczone, 34684
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Pinellas Park, Florida, Stany Zjednoczone, 33781
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Saint Petersburg, Florida, Stany Zjednoczone, 33716
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Tamarac, Florida, Stany Zjednoczone, 33321
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Tampa, Florida, Stany Zjednoczone, 33609
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Venice, Florida, Stany Zjednoczone, 34292
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Vero Beach, Florida, Stany Zjednoczone, 32960
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - West Palm Beach, Florida, Stany Zjednoczone, 33401
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Zephyrhills, Florida, Stany Zjednoczone, 33542
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Georgia
  - Atlanta, Georgia, Stany Zjednoczone, 30342
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Decatur, Georgia, Stany Zjednoczone, 30033
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Dunwoody, Georgia, Stany Zjednoczone, 30338
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Gainesville, Georgia, Stany Zjednoczone, 30501
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Lawrenceville, Georgia, Stany Zjednoczone, 30045
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Marietta, Georgia, Stany Zjednoczone, 30060
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Savannah, Georgia, Stany Zjednoczone, 31405
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Stockbridge, Georgia, Stany Zjednoczone, 30281
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Idaho
  - Eagle, Idaho, Stany Zjednoczone, 83616
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Idaho Falls, Idaho, Stany Zjednoczone, 83404
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Illinois
  - Morton Grove, Illinois, Stany Zjednoczone, 60053
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Peoria, Illinois, Stany Zjednoczone, 61636
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Rockford, Illinois, Stany Zjednoczone, 61103
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Indiana
  - Brownsburg, Indiana, Stany Zjednoczone, 46112
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Evansville, Indiana, Stany Zjednoczone, 47714
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Indianapolis, Indiana, Stany Zjednoczone, 46227
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Kansas
  - Kansas City, Kansas, Stany Zjednoczone, 66160
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Shawnee Mission, Kansas, Stany Zjednoczone, 66218
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Wichita, Kansas, Stany Zjednoczone, 67208
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Kentucky
  - Bowling Green, Kentucky, Stany Zjednoczone, 42101
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Owensboro, Kentucky, Stany Zjednoczone, 42303
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Louisiana
  - Monroe, Louisiana, Stany Zjednoczone, 71203
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Maryland
  - Cumberland, Maryland, Stany Zjednoczone, 21502
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Wheaton, Maryland, Stany Zjednoczone, 20902
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Massachusetts
  - Haverhill, Massachusetts, Stany Zjednoczone, 01830
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Worcester, Massachusetts, Stany Zjednoczone, 01605
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Michigan
  - Bingham Farms, Michigan, Stany Zjednoczone, 48025
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Saint Clair Shores, Michigan, Stany Zjednoczone, 48081
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Mississippi
  - Flowood, Mississippi, Stany Zjednoczone, 39232
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Jackson, Mississippi, Stany Zjednoczone, 39202
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Missouri
  - Florissant, Missouri, Stany Zjednoczone, 63031
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Saint Louis, Missouri, Stany Zjednoczone, 63131
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Montana
  - Kalispell, Montana, Stany Zjednoczone, 59901
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Nebraska
  - Lincoln, Nebraska, Stany Zjednoczone, 68516
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Omaha, Nebraska, Stany Zjednoczone, 68134
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Nevada
  - Las Vegas, Nevada, Stany Zjednoczone, 89128
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- New Hampshire
  - Nashua, New Hampshire, Stany Zjednoczone, 03060
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- New Jersey
  - Berkeley Heights, New Jersey, Stany Zjednoczone, 07922
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Clifton, New Jersey, Stany Zjednoczone, 07012
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- New Mexico
  - Albuquerque, New Mexico, Stany Zjednoczone, 87108
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- New York
  - Brooklyn, New York, Stany Zjednoczone, 11201
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Roslyn, New York, Stany Zjednoczone, 11576
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Syracuse, New York, Stany Zjednoczone, 13210
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- North Carolina
  - Charlotte, North Carolina, Stany Zjednoczone, 28210
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Hickory, North Carolina, Stany Zjednoczone, 28601
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Raleigh, North Carolina, Stany Zjednoczone, 27609
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Sanford, North Carolina, Stany Zjednoczone, 27330
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- North Dakota
  - Bismarck, North Dakota, Stany Zjednoczone, 58502
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Ohio
  - Cincinnati, Ohio, Stany Zjednoczone, 45242
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Oklahoma
  - Oklahoma City, Oklahoma, Stany Zjednoczone, 73104
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Tulsa, Oklahoma, Stany Zjednoczone, 74135
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Oregon
  - Bend, Oregon, Stany Zjednoczone, 97701
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Pennsylvania
  - Bethlehem, Pennsylvania, Stany Zjednoczone, 18017
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Erie, Pennsylvania, Stany Zjednoczone, 16508
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Limerick, Pennsylvania, Stany Zjednoczone, 19468
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Philadelphia, Pennsylvania, Stany Zjednoczone, 19152
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Pottstown, Pennsylvania, Stany Zjednoczone, 19464
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- South Carolina
  - Columbia, South Carolina, Stany Zjednoczone, 29204
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Greenville, South Carolina, Stany Zjednoczone, 29601
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  - Greer, South Carolina, Stany Zjednoczone, 29650
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  - Myrtle Beach, South Carolina, Stany Zjednoczone, 29572
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  - North Charleston, South Carolina, Stany Zjednoczone, 29406
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  - Taylors, South Carolina, Stany Zjednoczone, 29687
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- Tennessee
  - Knoxville, Tennessee, Stany Zjednoczone, 37909
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  - Memphis, Tennessee, Stany Zjednoczone, 38119
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  - Nashville, Tennessee, Stany Zjednoczone, 37205
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- Texas
  - Austin, Texas, Stany Zjednoczone, 78731
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  - Dallas, Texas, Stany Zjednoczone, 75231
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  - Houston, Texas, Stany Zjednoczone, 77090
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  - Lake Jackson, Texas, Stany Zjednoczone, 77566
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  - Lubbock, Texas, Stany Zjednoczone, 79424
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  - Mesquite, Texas, Stany Zjednoczone, 75150
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  - Nassau Bay, Texas, Stany Zjednoczone, 77058
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  - North Richland Hills, Texas, Stany Zjednoczone, 76180
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  - San Antonio, Texas, Stany Zjednoczone, 78217
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Sugar Land, Texas, Stany Zjednoczone, 77478
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Vermont
  - Burlington, Vermont, Stany Zjednoczone, 05401
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Virginia
  - Richmond, Virginia, Stany Zjednoczone, 23225
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Washington
  - Spokane, Washington, Stany Zjednoczone, 99204
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Tacoma, Washington, Stany Zjednoczone, 98405
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  - Wenatchee, Washington, Stany Zjednoczone, 98801
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- West Virginia
  - Clarksburg, West Virginia, Stany Zjednoczone, 26301
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
- Wisconsin
  - Milwaukee, Wisconsin, Stany Zjednoczone, 53226
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Racine, Wisconsin, Stany Zjednoczone, 53406
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Słowacja
- - Bratislava, Słowacja, 84231
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Dunajska Streda, Słowacja, 929 01
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  - Piestany, Słowacja, 921 12
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Tajwan
- - Keelung, Tajwan, 204
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Kuei Shan Hsiang, Tajwan, 33305
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Niao Sung Hsiang, Tajwan, 833
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Taichung, Tajwan, 40705
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  - Taipei, Tajwan, 112
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Ukraina
- - Dnipropetrovsk, Ukraina, 49008
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Donetsk, Ukraina, 83114
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  - Kharkiv, Ukraina, 61178
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  - Kiev, Ukraina, 04114
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  - Kyiv, Ukraina, 03151
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  - Odesa, Ukraina, 65026
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  - Poltava, Ukraina, 36038
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  - Simferopol, Ukraina, 95017
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  - Vinnitsa, Ukraina, 21000
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Vinnytsya, Ukraina, 21018
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Węgry
- - Baja, Węgry, 6500
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Balassagyarmat, Węgry, 2660
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Budapest, Węgry, 1062
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Debrecen, Węgry, 4032
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Esztergom, Węgry, 2500
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
  - Kiskunhalas, Węgry, 6400
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  - Nyiregyhaza, Węgry, 4400
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  - Satoraljaujhely, Węgry, 3980
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  - Szikszo, Węgry, 3800
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  - Veszprem, Węgry, 8200
    - For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Kryteria uczestnictwa

Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.

Kryteria kwalifikacji

Wiek uprawniający do nauki

18 lat i starsze (Dorosły, Starszy dorosły)

Akceptuje zdrowych ochotników

Nie

Płeć kwalifikująca się do nauki

Wszystko

Opis

Kryteria przyjęcia:

mieć ukończone 24 tygodnie udziału w badaniu H9B-MC-BCDO lub H9B-MC-BCDV lub ukończyć 100 tygodni udziału w badaniu H9B-MC-BCDM
Kobieta nie może być w ciąży, karmić piersią ani zajść w ciążę podczas badania

Kryteria wyłączenia:

Obecna obecność poważnego zaburzenia lub choroby

Plan studiów

Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.

Jak projektuje się badanie?

Szczegóły projektu

Główny cel: Leczenie
Przydział: Randomizowane
Model interwencyjny: Przydział równoległy
Maskowanie: Brak (otwarta etykieta)

Liczba ramion

Broń i interwencje

Grupa uczestników / Arm	Interwencja / Leczenie
Eksperymentalny: 120 miligramów (mg) LY2127399 Podawany co 4 tygodnie przez 240 tygodni uczestnikom badania BCDO lub badania BCDV. Uczestnicy, którzy bezpośrednio przed włączeniem otrzymywali placebo, otrzymają dawkę nasycającą 240 mg na początku leczenia. Lub Podawany co 4 tygodnie przez 168 tygodni uczestnikom badania BCDM.	Lek: LY2127399 Podawany podskórnie Inne nazwy: Tabalumab
Eksperymentalny: 90 mg LY2127399 Podawany co 2 tygodnie przez 240 tygodni uczestnikom badania BCDO lub badania BCDV. Uczestnicy, którzy bezpośrednio przed włączeniem otrzymywali placebo, otrzymają dawkę nasycającą 180 mg na początku leczenia. Lub Podawany co 2 tygodnie przez 168 tygodni uczestnikom badania BCDM.	Lek: LY2127399 Podawany podskórnie Inne nazwy: Tabalumab

Co mierzy badanie?

Podstawowe miary wyniku

Miara wyniku	Opis środka	Ramy czasowe
Liczba uczestników, u których wystąpiły zdarzenia niepożądane związane z leczeniem (TEAE), poważne zdarzenia niepożądane (SAE) i zdarzenia niepożądane o szczególnym znaczeniu (AESI) w okresie leczenia Ramy czasowe: do 84,4 tygodni w okresie leczenia	TEAE zdefiniowano jako zdarzenie, które po raz pierwszy wystąpiło lub nasiliło się w dniu lub po dacie pierwszego wstrzyknięcia i przed zakończeniem badania. AESI to infekcja, reakcje w miejscu wstrzyknięcia, nowotwór złośliwy, poważne niepożądane zdarzenia sercowo-naczyniowe (MACE), alergia i nadwrażliwość, depresja, samobójstwo/samookaleczenie i ciąża. MACE zdefiniowano jako 1 z rozstrzygniętych zdarzeń: zgon z przyczyn sercowo-naczyniowych, zawał mięśnia sercowego (MI), udar, hospitalizacja z powodu niestabilnej dławicy piersiowej, hospitalizacja z powodu niewydolności serca, zabieg rewaskularyzacji wieńcowej, zabieg rewaskularyzacji obwodowej, wstrząs kardiogenny w wyniku zawału mięśnia sercowego, reanimacja nagłego zgonu, poważny arytmia, hospitalizacja z powodu nadciśnienia tętniczego, incydent w tętnicach obwodowych. Podsumowanie SAE i innych niepoważnych zdarzeń niepożądanych, niezależnie od przyczyny, znajduje się w module Zgłaszane zdarzenia niepożądane.	do 84,4 tygodni w okresie leczenia
Odsetek uczestników, u których rozwinęły się przeciwciała anty-LY2127399 Ramy czasowe: Wartość wyjściowa do tygodni 4, 24, 48 i 72	Uczestnikami, u których pojawiły się przeciwciała anty-LY2127399 podczas leczenia, byli uczestnicy, u których jakiekolwiek próbki od wartości początkowej do tygodnia 72 i do 72. tygodnia oznaczały 4-krotny wzrost (wzrost o 2 rozcieńczenia) miana immunogenności w stosunku do miana wyjściowego lub uczestnicy, u których wynik testu na początku badania był ujemny i dodatni wynik po punkcie wyjściowym (przy mianie ≥1:20). Linię wyjściową definiuje się jako ostatnią niebrakującą obserwację w dniu lub przed datą pierwszego wstrzyknięcia LY2127399 w poprzednich badaniach lub badaniu BCDP. Odsetek uczestników z przeciwciałami anty-LY2127399 = (liczba uczestników z przeciwciałami anty-LY2127399 pojawiającymi się podczas leczenia / liczba ocenianych uczestników)*100.	Wartość wyjściowa do tygodni 4, 24, 48 i 72
Zmiana bezwzględnej liczby limfocytów B w stosunku do linii podstawowej Ramy czasowe: Wartość wyjściowa, tydzień 48	Oznaczenie klastra markerów powierzchniowych komórek (CD) 3 ujemne, CD20 dodatnie (CD3-CD20+) definiuje całkowitą dojrzałość komórek B. Antygen limfocytów B CD20 jest aktywowaną glikozylowaną fosfoproteiną występującą na powierzchni wszystkich dojrzałych limfocytów B. Wyjściowa liczba komórek B to średnia wartości z dnia lub przed datą pierwszego wstrzyknięcia badanego leku w poprzednich badaniach, w tym wizyt nieplanowanych. Zmiana dodatnia lub ujemna wskazywała odpowiednio na wzrost lub spadek liczby komórek B.	Wartość wyjściowa, tydzień 48
Zmiana poziomu immunoglobulin (Ig) w surowicy w stosunku do wartości wyjściowych Ramy czasowe: Wartość wyjściowa, tydzień 48	Immunoglobuliny (Ig) lub przeciwciała to duże białka wykorzystywane przez układ odpornościowy do identyfikacji i neutralizacji obcych cząstek, takich jak bakterie i wirusy. Ich prawidłowy poziom we krwi wskazuje na prawidłowy stan odporności. Zgłaszane są zmiany w stosunku do wyjściowych poziomów immunoglobuliny A (IgA), immunoglobuliny G (IgG) i immunoglobuliny M (IgM) w surowicy. Zmiana ujemna wskazywała na spadek poziomów Ig. Linię wyjściową definiuje się jako ostatnią niebrakującą obserwację w dniu lub przed datą pierwszego wstrzyknięcia LY2127399 w poprzednich badaniach lub badaniu BCDP.	Wartość wyjściowa, tydzień 48

Miary wyników drugorzędnych

Miara wyniku	Opis środka	Ramy czasowe
Odsetek uczestników z American College of Rheumatology 20% odpowiedzi (ACR20) Ramy czasowe: Wartość wyjściowa do tygodni 12, 24 i 48	ACR Responder Index to połączenie klinicznych, laboratoryjnych i funkcjonalnych pomiarów reumatoidalnego zapalenia stawów (RZS). ACR20 Pacjenci z reakcją na leczenie: mieli ≥20% poprawę w stosunku do wartości wyjściowych zarówno w liczbie 68 bolesnych, jak i 66 obrzękniętych stawów oraz ≥20% poprawę w co najmniej 3 z 5 kryteriów: ogólna ocena aktywności choroby przez uczestnika i lekarza, kwestionariusz oceny stanu zdrowia – wskaźnik niepełnosprawności (HAQ- DI) (które mierzyło postrzegany przez uczestników stopień trudności w wykonywaniu codziennych czynności), ból stawów i białko C-reaktywne (CRP). Linię wyjściową definiuje się jako ostatnią niebrakującą obserwację w dniu lub przed datą pierwszego wstrzyknięcia LY2127399 w poprzednich badaniach lub badaniu BCDP. Odsetek uczestników, którzy uzyskali odpowiedź ACR20 = (liczba osób z odpowiedzią ACR20 / liczba leczonych uczestników) * 100. Wszyscy uczestnicy, którzy z jakiegokolwiek powodu przerwali leczenie w ramach badania, zostali zdefiniowani jako NR w tym punkcie czasowym i w przyszłości.	Wartość wyjściowa do tygodni 12, 24 i 48
Zmiana w stosunku do wartości początkowej wyniku aktywności choroby na podstawie liczby 28 stawów i poziomu białka C-reaktywnego (DAS28-CRP) Ramy czasowe: Wartość wyjściowa, 240 tygodni		Wartość wyjściowa, 240 tygodni
Odsetek uczestników z odpowiedzią Europejskiej Ligi Przeciwko Reumatyzmowi opartej na DAS28 (EULAR-28) Ramy czasowe: Linia bazowa przez 240 tygodni		Linia bazowa przez 240 tygodni
Zmiana w stosunku do stanu wyjściowego w badaniu dotyczącym wyników medycznych 36-itemowy krótki formularz (SF-36) Wyniki domen ankiety zdrowotnej i wyniki podsumowujące Ramy czasowe: Wartość wyjściowa, 240 tygodni		Wartość wyjściowa, 240 tygodni
Zmiana w stosunku do linii bazowej łącznej liczby przetargów (68 łącznych liczb) Ramy czasowe: Wartość wyjściowa, 240 tygodni		Wartość wyjściowa, 240 tygodni
Zmiana liczby obrzękniętych stawów w stosunku do wartości początkowej (liczba 66 stawów) Ramy czasowe: Wartość wyjściowa, 240 tygodni		Wartość wyjściowa, 240 tygodni
Zmiana w stosunku do wartości wyjściowej w ocenie bólu przez uczestnika [wizualna skala analogowa (VAS)] Ramy czasowe: Wartość wyjściowa, 240 tygodni		Wartość wyjściowa, 240 tygodni
Zmiana od punktu początkowego w ogólnej ocenie aktywności choroby (VAS) uczestników Ramy czasowe: Wartość wyjściowa, 240 tygodni		Wartość wyjściowa, 240 tygodni
Zmiana w stosunku do wartości wyjściowych w ogólnej ocenie aktywności choroby (VAS) przez lekarzy Ramy czasowe: Wartość wyjściowa, 240 tygodni		Wartość wyjściowa, 240 tygodni
Zmiana w stosunku do wartości wyjściowej w Kwestionariuszu Oceny Zdrowia – Wskaźnik Niepełnosprawności (HAQ-DI) Ramy czasowe: Wartość wyjściowa, 240 tygodni		Wartość wyjściowa, 240 tygodni
Zmiana od wartości początkowej w CRP Ramy czasowe: Wartość wyjściowa, 240 tygodni		Wartość wyjściowa, 240 tygodni
Amerykańskie Kolegium Reumatologii Procentowej Poprawy (ACR-N) Ramy czasowe: Linia bazowa przez 240 tygodni		Linia bazowa przez 240 tygodni

Inne miary wyników

Miara wyniku	Ramy czasowe
Liczba uczestników, którzy zmarli w okresie leczenia i okresie obserwacji po leczeniu Ramy czasowe: Do 84,4 tygodni w okresie leczenia i przerwanie leczenia w ramach badania do 48 tygodni w okresie obserwacji	Do 84,4 tygodni w okresie leczenia i przerwanie leczenia w ramach badania do 48 tygodni w okresie obserwacji

Współpracownicy i badacze

Tutaj znajdziesz osoby i organizacje zaangażowane w to badanie.

Sponsor

Eli Lilly and Company

Śledczy

Dyrektor Studium: Call 1-877-CTLILLY(1-877-285-4559) or 1-317-615-4559 Mon - Fri 9AM - 5PM Eastern time (UCT/GMT - 5 hours, EST), Eli Lilly and Company

Daty zapisu na studia

Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.

Główne daty studiów

Rozpoczęcie studiów

1 czerwca 2011

Zakończenie podstawowe (Rzeczywisty)

1 lutego 2014

Ukończenie studiów (Rzeczywisty)

1 lutego 2014

Daty rejestracji na studia

Pierwszy przesłany

5 października 2010

Pierwszy przesłany, który spełnia kryteria kontroli jakości

5 października 2010

Pierwszy wysłany (Oszacować)

7 października 2010

Aktualizacje rekordów badań

Ostatnia wysłana aktualizacja (Rzeczywisty)

11 czerwca 2018

Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości

11 maja 2018

Ostatnia weryfikacja

1 maja 2018

Więcej informacji

Terminy związane z tym badaniem

Słowa kluczowe

Reumatyzm

Dodatkowe istotne warunki MeSH

Inne numery identyfikacyjne badania

13419 (Company internal)
H9B-MC-BCDP (Inny identyfikator: Eli Lilly and Company)

Te informacje zostały pobrane bezpośrednio ze strony internetowej clinicaltrials.gov bez żadnych zmian. Jeśli chcesz zmienić, usunąć lub zaktualizować dane swojego badania, skontaktuj się z register@clinicaltrials.gov. Gdy tylko zmiana zostanie wprowadzona na stronie clinicaltrials.gov, zostanie ona automatycznie zaktualizowana również na naszej stronie internetowej .

Badania kliniczne na LY2127399

Eli Lilly and Company

Zakończony

Badanie uczestników ze schyłkową niewydolnością nerek

Niewydolność nerek, przewlekła

Stany Zjednoczone
Eli Lilly and Company

Zakończony

Badanie LY2127399 w reumatoidalnym zapaleniu stawów

Reumatyzm

Stany Zjednoczone
Applied Molecular Evolution
Eli Lilly and Company

Zakończony

Badanie fazy 1 bezpieczeństwa LY2127399 w połączeniu z Bortezomibem

Szpiczak mnogi

Stany Zjednoczone
Eli Lilly and Company

Zakończony

Badanie reumatoidalnego zapalenia stawów u uczestników (FLEX O)

Reumatyzm

Argentyna, Indie, Stany Zjednoczone, Węgry, Bułgaria, Meksyk, Ukraina, Kolumbia, Tajwan, Polska, Japonia, Republika Korei, Nowa Zelandia, Rumunia, Afryka Południowa, Australia, Chorwacja, Litwa, Malezja, Federacja Rosyjska, Słow... i więcej
Eli Lilly and Company

Zakończony

Badanie uczestników z reumatoidalnym zapaleniem stawów (FLEX V)

Reumatyzm

Stany Zjednoczone, Niemcy, Tajwan, Francja, Japonia, Meksyk, Polska, Federacja Rosyjska, Hiszpania, Kolumbia, Argentyna, Grecja, Nowa Zelandia, Afryka Południowa, Australia, Republika Korei, Brazylia, Włochy, Malezja
Eli Lilly and Company

Zakończony

Badanie LY2127399 u uczestników z toczniem rumieniowatym układowym

Toczeń rumieniowaty układowy | Choroby autoimmunologiczne | Choroba tkanki łącznej

Indie, Stany Zjednoczone, Węgry, Rumunia, Hiszpania, Francja, Tajwan, Federacja Rosyjska, Zjednoczone Królestwo, Australia, Łotwa, Meksyk, Afryka Południowa, Kanada, Izrael, Brazylia, Serbia, Ekwador, Malezja, Nowa Zelandia, Tun...
Eli Lilly and Company

Zakończony

O badaniu otwartym u uczestników z toczniem rumieniowatym układowym (Illuminate-X)

Toczeń rumieniowaty układowy | Choroby autoimmunologiczne | Choroba tkanki łącznej

Stany Zjednoczone
Eli Lilly and Company

Zakończony

Badanie dla japońskich uczestników z reumatoidalnym zapaleniem stawów (RZS)

Reumatyzm

Japonia
Eli Lilly and Company

Zakończony

Badanie dla pacjentów z aktywnym reumatoidalnym zapaleniem stawów pomimo trwającej terapii metotreksatem

Reumatyzm

Stany Zjednoczone, Meksyk, Węgry, Indie, Argentyna, Chile, Ukraina, Australia, Rumunia, Niemcy, Polska, Słowacja
Eli Lilly and Company

Zakończony

Badanie japońskich uczestników reumatoidalnego zapalenia stawów

Reumatyzm

Japonia

Badanie otwarte dla uczestników z reumatoidalnym zapaleniem stawów

Wieloośrodkowe, otwarte badanie fazy 3b oceniające długoterminowe bezpieczeństwo i skuteczność LY2127399 u pacjentów z reumatoidalnym zapaleniem stawów (RZS)

Przegląd badań

Status

Warunki

Interwencja / Leczenie

Szczegółowy opis

Typ studiów

Zapisy (Rzeczywisty)

Faza

Kontakty i lokalizacje

Lokalizacje studiów

Kryteria uczestnictwa

Kryteria kwalifikacji

Wiek uprawniający do nauki

Akceptuje zdrowych ochotników

Płeć kwalifikująca się do nauki

Opis

Plan studiów

Jak projektuje się badanie?

Szczegóły projektu

Liczba ramion

Broń i interwencje

Grupa uczestników / Arm

Interwencja / Leczenie

Co mierzy badanie?

Podstawowe miary wyniku

Miara wyniku

Opis środka

Ramy czasowe

Miary wyników drugorzędnych

Miara wyniku

Opis środka

Ramy czasowe

Inne miary wyników

Miara wyniku

Ramy czasowe

Współpracownicy i badacze

Sponsor

Śledczy

Daty zapisu na studia

Główne daty studiów

Rozpoczęcie studiów

Zakończenie podstawowe (Rzeczywisty)

Ukończenie studiów (Rzeczywisty)

Daty rejestracji na studia

Pierwszy przesłany

Pierwszy przesłany, który spełnia kryteria kontroli jakości

Pierwszy wysłany (Oszacować)

Aktualizacje rekordów badań

Ostatnia wysłana aktualizacja (Rzeczywisty)

Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości

Ostatnia weryfikacja

Więcej informacji

Terminy związane z tym badaniem

Słowa kluczowe

Dodatkowe istotne warunki MeSH

Inne numery identyfikacyjne badania

Badania kliniczne na LY2127399

Wyszukaj podobne próby

Sponsorzy i współpracownicy

Warunki medyczne

Interwencje lekowe

CROs by country

CROs in Peru

Warunki

Rzadkie choroby

Interwencje lekowe

Suplementy diety

Sponsor / Współpracownicy

Lokalizacje