Prospective Cohort Study on Cognition and Cardiovascular Disease of Sedentary Behaviors in Children
27 czerwca 2018 zaktualizowane przez: CHEN Yajun
The prospective cohort study is set up to address research questions dealing with sedentary lifestyle-related events mainly including cognition and cardiovascular-related disease in children .Participants aged 7-12 years old from five primary schools in Guangzhou,Guangdong province will be recruited and followed up to evaluate the risk factors of cognition and cardiovascular-related disease.
Objective measurements combined with questionnaire-data-based information on a wide range of lifestyle factors and cognition were applied in this study.
Przegląd badań
Status
Rejestracja na zaproszenie
Szczegółowy opis
There are three stages in this project.At first stage,information about socio-demographic, psychological status, physical activity,sleep and diet were collected by a multi-components questionnaire survey.The Strengths and Difficulties Questionnaire(SDQ) and Behavior Rating Inventory of Executive Function(BRIEF) were conducted at the same time. Anthropometric measurement including height, weight, waist and hip circumferences, blood pressure and fat mass were conducted.Besides,blood samples were collected to measure total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C).
At second stage,participants were classified for 4 subgroups as follows: Low active-high sedentary;low active-low sedentary; high active-high sedentary;high active-low sedentary by different sedentary status and physical activity levels according to the international standard. Later cardiorespiratory fitness was assessed by the 20-m shuttle run test. Accelerometer GT3X+ Actigraph with physical activity log,Combined Raven's test, a series of psychometric paradigms were measured for further studies.
At third stage,we will explore the related neuropsychological mechanism using the technology of event-related potentials (ERPs).
About 1000 participants (7-12 years old) will be prospectively followed up. The associations between sedentary lifestyle and risks for cognition and cardiovascular-related disease will be evaluated.
Typ studiów
Obserwacyjny
Zapisy (Oczekiwany)
1000
Kryteria uczestnictwa
Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.
Kryteria kwalifikacji
Wiek uprawniający do nauki
7 lat do 12 lat (Dziecko)
Akceptuje zdrowych ochotników
Nie dotyczy
Płeć kwalifikująca się do nauki
Wszystko
Metoda próbkowania
Próbka bez prawdopodobieństwa
Badana populacja
Primary school students aged 7 to 12 in Guangzhou
Opis
Inclusion Criteria:
- 7-12 years old
- Children with normal intelligence measured by Raven Good vision.
- Right hand.
Exclusion Criteria:
- Children with mental health and behavioral problems in this study were found to have developmental behavior disorders, such as ADHD, ASD.
- There are serious liver and kidney diseases, cardiovascular diseases, hematologic diseases or malignant tumors.
Plan studiów
Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.
Jak projektuje się badanie?
Szczegóły projektu
- Modele obserwacyjne: Kohorta
- Perspektywy czasowe: Spodziewany
Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Self-reported physical activity and sedentary lifestyle.
Ramy czasowe: 2017.01-2026.12
|
Using International Physical Activity Questionnaire-Short-Chinese（IPAQ-S-C）to assess the frequency and duration of activity and sedentary lifestyle（SL） in the last 7 days .Subjects with moderate activity and vigorous activity(MVPA)≥60min/day were classified into high PA subgroup while those with MVPA<150min/week were classified into low PA subgroup according to the international standard.Subjects with SL≥gender-, age-specific 75% percentile were assigned to the high SL subgroup and< gender-, age-specific 25% percentile were assigned to the low SL subgroup.
|
2017.01-2026.12
|
Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Anthropometric
Ramy czasowe: 2017.01-2026.12
|
Height was measured to the nearest millimeter and weight was measured to the nearest 0.1kg.Waist circumference(WC) was measured to the nearest millimeter at the level of 1cm above umbilicus with a steel tape.
Body mass index(BMI) was calculated as body weight in kilograms divided by height in meters squared (kg/m2).Human body fat mass was measured by means of the bio-impedance assay ( BIA ) .Blood pressure was recorded as systolic blood pressure (SBP) and diastolic blood pressure (DBP) .
Blood pressure was measured for 2 times with one-minute interval.
|
2017.01-2026.12
|
|
Biochemical indicator
Ramy czasowe: 2017.01-2026.12
|
Fasting blood glucose,total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C).
|
2017.01-2026.12
|
|
Cardiorespiratory Fitness(CRF)
Ramy czasowe: 2017.01-2026.12
|
CRF was assessed by the 20-m shuttle run test.Estimations of submaximal oxygen consumption (VO2max) were obtained using Leger's formulae.
|
2017.01-2026.12
|
|
Self-reported cognition
Ramy czasowe: 2017.01-2026.12
|
The Behavior Rating Inventory of Executive Function-Parents(BRIEF-P) examines parents' report for the frequency of "problematic" behaviors that their child displayed at home during the previous 6 months.
It contains 86 items (every item chooses from three dimensions "No", "Sometimes" and "Often" ) within eight theoretically and empirically derived clinical scales that measure different aspects of executive functioning: Inhibit, Shift, Emotional Control, Initiate, Working Memory, Plan/Organize, Organization of Materials and Monitor, and three overarching composites (i.e.
Behavioral Index [BRI, obtained Inhibit, Shift, Emotional Control], Metacognition Index [MI, obtained Initiate, Working Memory, Plan/Organize, Organization of Materials and Monitor] and Global Executive Composite [GEC]).The higher the score, the worse the executive function.
|
2017.01-2026.12
|
|
Objective measurement of physical activity and sedentary lifestyle.
Ramy czasowe: 2017.01-2026.12
|
Physical activity was measured using accelerometer GT3X+ Actigraph for 7 days continuously.
The main measurement result was duration of physical activity.
A wear time of ≥480 minutes/day was used as the criterion for a valid day, and ≥4 days (at least 3 weekdays and 1 weekend) were used as the criteria for a valid 7-day period of accumulated data.The cut-points for classify physical activity intensity levels are different, thus this will be specifically described in subsequent articles.
|
2017.01-2026.12
|
|
Corsi block-tapping task
Ramy czasowe: 2017.01-2026.12
|
Three accuracy measures were registered: The number of blocks of the longest correct sequence, the total number of correctly reproduced sequences, and the product of these two measures.
|
2017.01-2026.12
|
|
Stroop task
Ramy czasowe: 2017.01-2026.12
|
Response accuracy and reaction time(RT) were collected to assess behavioral performance.
|
2017.01-2026.12
|
|
Wisconsin Card Sorting Test(WCST)
Ramy czasowe: 2017.01-2026.12
|
Children with poor executive function exhibited a higher error rate and slower reaction times.
|
2017.01-2026.12
|
|
Combined Raven's Test
Ramy czasowe: 2017.01-2026.12
|
The correct number of questions is calculated to reflect intelligence level.(Level
1: a test standard score of high intelligence equal to or greater than 95% of the constant module of the same age.Level 2: good intelligence is between 75% and 95%.Level 3:average intelligence is between 25% and 75%.
Level 4:the low level of intelligence is between 5% and 25%.Level 5: mental retardation is less than 5%)
|
2017.01-2026.12
|
|
Event-related potentials
Ramy czasowe: 2018.09-2026.12
|
Assessing cognition using the Event-Related Potentials (ERPs) methodology of certain early and late ERPs (i.e.
P1, N1, N2, P2, P3).EEG activity was collected during the cognitive tasks from 64 electrode sites to derive and assess separately the ERPs amplitude and latency measures.
|
2018.09-2026.12
|
Współpracownicy i badacze
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Sponsor
Publikacje i pomocne linki
Osoba odpowiedzialna za wprowadzenie informacji o badaniu dobrowolnie udostępnia te publikacje. Mogą one dotyczyć wszystkiego, co jest związane z badaniem.
Publikacje ogólne
- Lv Y, Cai L, Zeng X, Gui Z, Lai L, Tan W, Chen Y. Association between weekend catch-up sleep and executive functions in Chinese school-aged children. J Clin Sleep Med. 2020 Aug 15;16(8):1285-1293. doi: 10.5664/jcsm.8494.
- Lv Y, Cai L, Gui Z, Zeng X, Tan M, Wan N, Lai L, Lu S, Tan W, Chen Y. Effects of physical activity and sedentary behaviour on cardiometabolic risk factors and cognitive function in children: protocol for a cohort study. BMJ Open. 2019 Oct 31;9(10):e030322. doi: 10.1136/bmjopen-2019-030322.
Daty zapisu na studia
Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.
Główne daty studiów
Rozpoczęcie studiów (Rzeczywisty)
1 stycznia 2017
Zakończenie podstawowe (Oczekiwany)
31 grudnia 2026
Ukończenie studiów (Oczekiwany)
31 grudnia 2026
Daty rejestracji na studia
Pierwszy przesłany
31 maja 2018
Pierwszy przesłany, który spełnia kryteria kontroli jakości
27 czerwca 2018
Pierwszy wysłany (Rzeczywisty)
11 lipca 2018
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Rzeczywisty)
11 lipca 2018
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
27 czerwca 2018
Ostatnia weryfikacja
1 czerwca 2018
Więcej informacji
Terminy związane z tym badaniem
Dodatkowe istotne warunki MeSH
Inne numery identyfikacyjne badania
- 8167120522
Informacje o lekach i urządzeniach, dokumenty badawcze
Bada produkt leczniczy regulowany przez amerykańską FDA
Nie
Bada produkt urządzenia regulowany przez amerykańską FDA
Nie
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