Effect of High Intensity Aerobic & Resistance Interval Training on Body Composition, Visceral Adiposity and Myocardial Function in Overweight and Obese Adults
12 stycznia 2021 zaktualizowane przez: Foundation University Islamabad
The obesity epidemic, predisposing to cardio-metabolic diseases, has increased two-folds over the last decade with a global alarming cost of obesity-associated illnesses, thus representing a grave peril for the survival of public health care systems.
It is need of the time to develop evidence-based, time-efficient and cost-effective strategies to prevent and manage obesity.
This study would compare the effects of 2 types of exercise regimes providing data on their beneficial effects on body composition and myocardial function along with reducing the central adiposity.
This study may also be used as a novel intervention strategy for primary prevention of cardiovascular and metabolic diseases by modification of a major risk factor i.e. obesity in Pakistani population, consequently reducing the burden of morbidity and mortality from cardiometabolic diseases.
Przegląd badań
Status
Nieznany
Warunki
Interwencja / Leczenie
Szczegółowy opis
Obesity is one of the major public health issues of this century.
Over the last decade, the prevalence of obesity has increased globally, making it an emerging epidemic and threatening the survival of health care systems.
Obesity has long been recognized as the major factor predisposing to cardio-metabolic diseases.The positive role of structured exercise for reducing the mortality and morbidity rates of obese and sedentary adults is well established.
But exercise engagement is seen to be quite low in obese adults mainly due to lack of time and non-adherence to exercise training programs.
Current trends are now focusing towards another type of exercise regime known as high intensity interval training (HIIT), which is composed of repetitive short to long (< 45 sec to 4 min) bouts of high intensity exercise alternating with rest or recovery periods.
Resistance training can also stimulate changes in body composition indices as well as maintain the reduced fat mass after training.
Thus resistance exercises are recommended as an adjunct for obesity management by reduction in risk factors.
Hence, this study is designed to determine the effects of high intensity interval training in combination with resistance exercises verses moderate intensity continuous training on multiple outcome variables including body composition parameters, visceral adiposity, lipid profile and myocardial function in overweight and obese adult population of Pakistan.
Afte r obtaining written informed consent from paricipants, they will be screened using 2020 PAR-Q plus and randomly allocated to one of the 2 groups.
A self-structured demographic sheet would be employed for recording demographics and required data including the findings of lab investigations.
Then participants will be required to undergo all the physical assessment measures such as anthropometric data, 6 minute walk test, lipid profile, body composition analysis and echocardiography.
Physical activity levels and QOL would be assessed by filling IPAQ and SF 36 respectively.
Exercise training plans would be performed thrice a week on alternate days for a total duration of 10 weeks.
All measurements (anthropometric, cardiac, blood and body composition analyses) would be performed at baseline and later after the 10 weeks intervention period.
Exercise intensity will be determined by individualized target heart rate zones using Karvonen formula.
Strength training intensity will be determined based on 1-RM.
Necessary adjustments to speed/grade and resistance will be made over the course of the intervention to ensure that target heart rate zones are achieved at all times.
Apart from the exercise programs, a general similar dietary guidance by a nutritionist would also be provided to both of the groups to avoid unhealthy dietary habits.
Typ studiów
Interwencyjne
Zapisy (Oczekiwany)
52
Faza
- Nie dotyczy
Kontakty i lokalizacje
Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.
Lokalizacje studiów
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Federal
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Islamabad, Federal, Pakistan, 46000
- Rekrutacyjny
- Foundation University Institute of Rehabilitation Sciences.
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Kontakt:
- Zara Khalid, PhD*
- Numer telefonu: +92 333 5415822
- E-mail: zara.khalid@fui.edu.pk
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Kryteria uczestnictwa
Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.
Kryteria kwalifikacji
Wiek uprawniający do nauki
18 lat do 55 lat (Dorosły)
Akceptuje zdrowych ochotników
Nie
Płeć kwalifikująca się do nauki
Wszystko
Opis
Inclusion Criteria:
- Individuals categorized as Overweight (BMI 23.0 to 24.9) and Obese-Class I (BMI 25.0 to 29.9).
- Both males & females willing to participate in the study.
- Otherwise healthy young adults aged 18-35 and middle-aged adults (36-55 years).
- No participation in an exercise or PA program during the last 6 months prior to the study.
- Participants able to complete 6-minute walk test as sub-maximal evaluation test without provoking sign and symptoms.
Exclusion Criteria:
- Any diagnosed neuromuscular, cardiac, renal, lung, liver disease.
- Individuals with implantable electrical devices such as pacemakers.
- Any physical or psychological dysfunction that hinders participation in the study.
- Individuals already participating in any structured program for weight loss including dietary interventions or usage of nutritional supplements.
- Individuals unable to complete 6 minute walk test due to any reason (dyspnea, fatigue, chest pain etc).
Plan studiów
Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.
Jak projektuje się badanie?
Szczegóły projektu
- Główny cel: Leczenie
- Przydział: Randomizowane
- Model interwencyjny: Przydział równoległy
- Maskowanie: Pojedynczy
Broń i interwencje
Grupa uczestników / Arm |
Interwencja / Leczenie |
|---|---|
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Eksperymentalny: High Intensity Interval Training Group
Participants in this group will initially undergo continuous aerobic training to achieve a baseline fitness level, after which HIIT and resistance training will be employed.
Warm-up period will be followed by 4 bouts of 4-minute interval treadmill running and stationary bike cycling at 80-95% of the measured HR reserve, interspersed with active recovery phase at 55-70% HRR.
After this resistance exercises will be performed in a circuit fashion for strengthening the upper limbs, lower limbs and trunk.
The session will be ended with a 5-7 minute cool-down period
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4x4 min intervals of high intensity treadmill running (80-95% of HRR, RPE 7-10 on Borg's category ratio scale of perceived exertion) interspersed with active recovery (slow jogging or fast walking at 50-70% HRR).
HIIT-Resistance exercises 2 sessions per week, RPE 5 (hard) 6-8 RM, 1-3 sets of as many repetitions as possible in 60 seconds, active recovery 20-60 seconds b/w exercises,
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Aktywny komparator: Moderate Intensity Continuous Training Group
Participants in this group will also initially undergo continuous aerobic training to achieve a baseline fitness level, after which the intensity will be increased to moderate continuous training achieving 55-70% of HRR.
Every session will be preceded by appropriate warm-up and end with cool down.
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Moderate intensity continuous Aerobic exercises (Stationary cycling for 15-20 min followed by treadmill walking for 15-20 min) at 55-70% 55-70% of HRR, RPE 3-4 on Borg's category ratio scale of perceived exertion.
The session will be preceded by 5-7 minute warm-up & 7-10 min cool-down.
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Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
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Percentage Body Fat
Ramy czasowe: 10 weeks
|
Percentage body fat will be measured using Bioelectrical Impedance Analyzer (Inbody 770) and expressed in forms of percentage (%).
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10 weeks
|
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Visceral fat area
Ramy czasowe: 10 weeks
|
Visceral fat area will be measured using Bioelectrical Impedance Analyzer (Inbody 770) and expressed in form of centimeter square.
|
10 weeks
|
Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Left Ventricular Mass
Ramy czasowe: 10 weeks
|
Left Ventricular Mass depicting myocardial function will be assessed via Echocardiography
|
10 weeks
|
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Left Ventricular Ejection Fraction
Ramy czasowe: 10 weeks
|
Left Ventricular Ejection Fraction depicting myocardial function will be assessed via Echocardiography
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10 weeks
|
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Cholesterol/HDL ratio
Ramy czasowe: 10 weeks
|
Will be analyzed using Lipid Profile blood testing.
A higher score represents poor outcome.
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10 weeks
|
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Fat free mass
Ramy czasowe: 10 weeks
|
Fat free mass will be measured using Bioelectrical Impedance Analyzer (Inbody 770) and will be expressed in kg.
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10 weeks
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Współpracownicy i badacze
Tutaj znajdziesz osoby i organizacje zaangażowane w to badanie.
Sponsor
Daty zapisu na studia
Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.
Główne daty studiów
Rozpoczęcie studiów (Rzeczywisty)
25 listopada 2020
Zakończenie podstawowe (Oczekiwany)
30 grudnia 2021
Ukończenie studiów (Oczekiwany)
30 grudnia 2021
Daty rejestracji na studia
Pierwszy przesłany
1 stycznia 2021
Pierwszy przesłany, który spełnia kryteria kontroli jakości
12 stycznia 2021
Pierwszy wysłany (Rzeczywisty)
14 stycznia 2021
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Rzeczywisty)
14 stycznia 2021
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
12 stycznia 2021
Ostatnia weryfikacja
1 stycznia 2021
Więcej informacji
Terminy związane z tym badaniem
Dodatkowe istotne warunki MeSH
Inne numery identyfikacyjne badania
- FUI/CTR/2020/13
Plan dla danych uczestnika indywidualnego (IPD)
Planujesz udostępniać dane poszczególnych uczestników (IPD)?
NIE
Informacje o lekach i urządzeniach, dokumenty badawcze
Bada produkt leczniczy regulowany przez amerykańską FDA
Nie
Bada produkt urządzenia regulowany przez amerykańską FDA
Nie
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