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Tests of Functional Magnetic Resonance Imaging Techniques

19 november 2021 uppdaterad av: National Institutes of Health Clinical Center (CC)

Imaging Techniques in fMRI and fMRI Reproducibility: An NIH/FDA Interagency Collaboration

Background:

- Functional magnetic resonance imaging (fMRI) is used to study the brain. It takes a series of pictures that can be used to look at how the brain processes information. It is used to study problems with thinking, language, and movement, among other things. Researchers are working to develop new and better fMRI techniques. To test these techniques, they want to perform fMRI scans on healthy volunteers.

Objectives:

- To test different fMRI techniques in healthy volunteers.

Eligibility:

- Healthy volunteers at least 18 years of age.

Design:

  • Participants will be screened with a physical exam and medical history.
  • Participants will have fMRI scans of the brain. During these scans, they will be asked to perform simple tasks. These tasks may involve language, thinking, or motor skills. The scanning sessions will last up to 2 hours.
  • Participants may be asked to return for additional fMRI scans over several years.

Studieöversikt

Status

Avslutad

Betingelser

Detaljerad beskrivning

Functional magnetic resonance imaging (fMRI) is a non invasive imaging technique that enables scientists to understand the biological basis of higher order cognitive functioning such as emotions, attention, language and visual processing. It has been used as a research tool since the 1980 s. Recently, fMRI has received approval by the Center for Medicare and Medicaid Services (CMS) to be used clinically which we believe will drastically increase its use in clinical decision making by physicians in the very near future. However, currently implemented imaging techniques have technical and physiologic limitations such as susceptibility artifacts, image distortions, physiological noise, and MRI induced energy deposition from radiomagnetic waves typically used in fMRI acquisitions that may potentially reduce the clinical effectiveness of this imaging modality. This protocol is a unique technical development pilot study being conducted jointly by researchers at the National Institutes of Health (NIH) and the US Food and Drug Administration (FDA) to evaluate the performance of physiologic and technical factors of fMRI imaging methods and equipment that may affect image quality, reproducibility, and reliability in the clinical setting. These studies are an important basis upon which improved regulatory evaluation of new functional imaging technologies can be performed as these technologies become increasingly used in patient care in the future.

Studietyp

Observationell

Inskrivning (Faktisk)

13

Kontakter och platser

Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.

Studieorter

  • Förenta staterna
    • Maryland
      • Bethesda, Maryland, Förenta staterna, 20892
        • National Institutes of Health Clinical Center, 9000 Rockville Pike

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

18 år till 110 år (Vuxen, Äldre vuxen)

Tar emot friska volontärer

Nej

Kön som är behöriga för studier

Allt

Testmetod

Icke-sannolikhetsprov

Studera befolkning

Healthy volunteers willing to come to NIH or are already part of an existing NIH protocol.

Beskrivning

  • INCLUSION CRITERIA:
  • Healthy volunteers, new or from current NIH protocols are eligible. Healthy volunteers will be defined according the history obtained from reported medical history, medical record (reported at registration), the MRI safety questionnaire, and a clinical grade noncontrast brain MRI.
  • Willing to travel to the NIH for follow-up visits
  • Greater than 18 years old
  • Able to understand and sign informed consent.
  • Bilingual or multilingual subjects can participate in this study as long as the subjects are also fluent in English. Subjects do not need to be native or monolingual speakers of English.

EXCLUSION CRITERIA:

The following criteria will be used to exclude subjects from participating in this protocol:

  • Implanted metal clips or wires of the type which may concentrate radiofrequency fields or cause tissue damages from twisting in a Magnetic field. Examples:

    • Aneurysm clip, implanted neural stimulator,
    • Implanted cardiac pacemaker, defibrillator, or certain other implanted electrical or metallic devices,
    • Cochlear implant, ocular foreign body (metal shavings),
    • Any implanted device (pumps, infusion devices, etc.),
    • Shrapnel injuries,
    • History of metal in head or eyes or other parts of the body.
    • Vagus Nerve Stimulators (VNS)
    • Subjects with tattoos that contain metal.
  • Pregnant women
  • Over 350 lbs because of the weight limit of the MRI table
  • Prior surgery that may render performing the MRI to be unsafe.
  • Untreatable claustrophobia otherwise requiring anesthesia or antianxiety medications that may alter the subject s ability to perform the tasks during fMRI scanning.
  • Subjects will be asked to refrain from drinking or eating caffeinated foods or drinks the morning of the scan that can result in vessel vasoconstriction prior to the scan.
  • Any contraindications that the Physician identifies from the Subject s reported history, MRI Safety Questionnaire and/or medical record.

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

Kohorter och interventioner

Grupp / Kohort
Volunteers
Healthy Volunteers

Vad mäter studien?

Primära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
evaluation of fMRI techniques
Tidsram: Study day 1, followup visit(s)
To test different fMRI techniques in healthy volunteers.
Study day 1, followup visit(s)

Samarbetspartners och utredare

Det är här du hittar personer och organisationer som är involverade i denna studie.

Sponsor

National Institutes of Health Clinical Center (CC)

Utredare

  • Huvudutredare: Nadia M Biassou, M.D., National Institutes of Health Clinical Center (CC)

Publikationer och användbara länkar

Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.

Allmänna publikationer

Användbara länkar

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Faktisk)

19 mars 2015

Primärt slutförande (Faktisk)

1 november 2017

Avslutad studie (Faktisk)

1 november 2017

Studieregistreringsdatum

Först inskickad

20 oktober 2012

Först inskickad som uppfyllde QC-kriterierna

20 oktober 2012

Första postat (Uppskatta)

23 oktober 2012

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)

22 november 2021

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

19 november 2021

Senast verifierad

1 november 2021

Mer information

Termer relaterade till denna studie

Nyckelord

Andra studie-ID-nummer

  • 130003
  • 13-CC-0003

Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .

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