Reference Database & Longitudinal Registry of the Normal and Pathological Aging Brain ((BNA™))

For ALL arms:

Inclusion Criteria:

• Currently resides in The Villages community
• Age 50-years and above.
• Able to speak, read and understand English
• Willingness to participate and able to give informed consent.
• If corrected vision: only Glasses should be used during the study testing

Exclusion Criteria:

• Currently with lice or open wounds on scalp.
• Any CNS neurologic disorder
• Significant sensory deficits.
• Use of a hearing aid that occupies the ear canal
• Any neuropsychological disorders
• History of special education
• Substance abuse in the last 3 months
• History of any clinically significant brain trauma as determined by the investigator.
• Clinically diagnosed with a concussion in the past year.

For Arm 1 Healthy

Inclusion Criteria:

• BDI score <14
• Subjects Not meeting diagnostic criteria for MDD per the DSM IV-TR,
• MMSE score ≥25

Exclusion Criteria:

• Any chronic disease or condition which affects the nervous system as determined by clinical neurological evaluation, medical history or PI discretion.
• Any psychiatric disorder,
• History of any medication affecting CNS within the last 3 months

For Arm 2 Early Alzheimer's Disease

Inclusion Criteria:

• BDI score <14
• Subjects Not meeting diagnostic criteria for MDD per the DSM IV-TR, as determined by clinical evaluation by a research clinician and the Mini International Neuropsychiatric Interview (MINI).
• MMSE score <24
• MoCA<20
• Presence of an early and significant episodic memory impairment

Exclusion Criteria:

• Any chronic disease or condition other than current pathology
• Any other psychiatric disorder
• CNS medications within the short period of time prior to the EEG testing which are not in a medically stable treatment phase.

For Arm 3 Depression

Inclusion Criteria:

• BDI score >14
• Subjects meeting full diagnostic criteria for MDD without psychotic features per the DSM IV-TR
• HAM-D 17-item: Total score of 16 or higher at visit 1.

Exclusion Criteria:

• Any chronic disease or condition other than current pathology
• Any psychiatric disorder other than Depression
• CNS medications within the short period of time prior to the EEG testing which are not in a medically stable treatment phase.

For Arm 4 Mild Cognitive Impairment

Inclusion Criteria:

• BDI score <14
• Subjects Not meeting diagnostic criteria for MDD per the DSM IV-TR
• MMSE scores according to Number of years of Education:

MMSE score Years of Education 17-18 ≤6 20-21 7-8 23-24 ≥10

-20<MoCA score >26

Exclusion Criteria:

• Any chronic disease or condition other than current pathology
• Any other psychiatric disorder
• CNS medications within the short period of time prior to the EEG testing which are not in a medically stable treatment phase.