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Effect of Isometric Handgrip Exercise on Blood Pressure in Pregnant Women (GRIP4HEALTH)

21 maj 2026 uppdaterad av: Carina Enea, University of Poitiers

Effect of Isometric Handgrip Exercise on Cardiovascular and Cognitive Responses in Normotensive and Hypertensive Pregnant Women (GRIP4HEALTH)

Hypertension during pregnancy is a major public health concern, increasing the risk of cardiovascular complications for both the mother and the fetus. Women with chronic hypertension are at higher risk of adverse outcomes, and elevated blood pressure during pregnancy has also been associated with long-term cardiovascular and cognitive impairments.Regular physical activity is recognized as an effective non-pharmacological strategy to reduce blood pressure. Among different exercise modalities, isometric exercise has shown promising effects in lowering blood pressure in the general population, with minimal cardiovascular strain. However, its effects and safety in pregnant women, particularly those with hypertension, remain poorly understood.In addition to cardiovascular alterations, hypertension during pregnancy may also impact cognitive function, potentially through changes in cerebral perfusion and vascular function. Despite these associations, the combined cardiovascular and cognitive responses to exercise in this population have not been fully explored.This study aims to investigate the effects of isometric handgrip exercise on cardiovascular and cognitive responses in pregnant women with and without chronic hypertension, in order to better understand its potential as a safe and effective non-pharmacological intervention during pregnancy.

Studieöversikt

Status

Rekrytering

Betingelser

Intervention / Behandling

Detaljerad beskrivning

Hypertension during pregnancy is a major public health concern associated with increased maternal and fetal morbidity, and long-term cardiovascular risk. Women with chronic hypertension are at higher risk of complications such as preeclampsia, preterm birth, and adverse neonatal outcomes. In addition, growing evidence suggests that hypertensive disorders of pregnancy may also be associated with long-term alterations in cardiovascular function and cognitive performance.During pregnancy, physiological changes in blood pressure regulation and vascular function may further complicate the management of hypertension. Pharmacological treatment options are limited due to potential risks for the fetus, highlighting the need for safe and effective non-pharmacological strategies.Physical exercise is recognized as an effective approach to reduce blood pressure and improve cardiovascular health in the general population. Among the different exercise modalities, isometric exercise has shown particularly promising effects in reducing blood pressure, with a low cardiovascular load. This modality may therefore represent an attractive option for pregnant women, as it can be performed safely with minimal physiological stress. However, despite these potential benefits, the effects and safety of isometric exercise during pregnancy, particularly in hypertensive women, remain poorly understood.In addition to cardiovascular alterations, hypertension during pregnancy may impact cognitive function, potentially through changes in cerebral perfusion and vascular regulation. Although physical activity has been associated with improvements in cognitive performance in the general population, the acute effects of exercise on cognitive function during pregnancy have not been well established.The aims of this study are:First, to evaluate the effect of isometric handgrip exercise on 24-hour blood pressure in pregnant women with and without chronic hypertension.Second, to compare cardiovascular responses to isometric exercise between normotensive and hypertensive pregnant women, including brachial and central blood pressure, arterial stiffness, and heart rate.Third, to examine differences in cognitive performance between normotensive and hypertensive pregnant women, and to explore the relationship between cardiovascular responses and cognitive outcomes.

Studietyp

Interventionell

Inskrivning (Beräknad)

30

Fas

  • Inte tillämpbar

Kontakter och platser

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Studiekontakt

Studera Kontakt Backup

Studieorter

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

  • Vuxen

Tar emot friska volontärer

Ja

Beskrivning

Inclusion Criteria:

  • Pregnant women covered by the French National Health Insurance system
  • Pregnant women who do not object to participation in the study
  • Women belonging to one of the following two groups:
  • Women with chronic hypertension present before pregnancy (diagnosed within the past 5 years), defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg, without antihypertensive treatment
  • Normotensive pregnant women, defined as systolic blood pressure (SBP) < 140 mmHg and diastolic blood pressure (DBP) < 90 mmHg before pregnancy

Exclusion Criteria:

  • Current treatment for chronic or gestational hypertension
  • Known cardiovascular disease other than chronic hypertension
  • Age under 18 years
  • Persons deprived of liberty
  • Inability to speak or adequately understand French
  • Persons hospitalized without consent who are not subject to legal protection measures, and persons admitted to a health or social institution for purposes other than research
  • Persons currently excluded from participation in another research study
  • Persons under judicial protection or guardianship Type 1 or type 2 diabetes
  • Severe or extreme obesity (BMI ≥ 40 kg/m²)
  • Thyroid disease
  • Heavy smoking

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

  • Primärt syfte: Förebyggande
  • Tilldelning: Randomiserad
  • Interventionsmodell: Crossover tilldelning
  • Maskning: Ingen (Open Label)

Vapen och interventioner

Deltagargrupp / Arm
Intervention / Behandling
Övrig: Normotensive Pregnant Women
Pregnant women without chronic hypertension. Participants in this arm complete both the isometric handgrip exercise session and the control rest session in randomized order.
Beteende: Isometric Handgrip Exercise
Isometric handgrip exercise performed at 30% of maximal voluntary contraction, consisting of four 2-minute contractions with one-minute rest intervals between efforts. The exercise is performed using a handgrip dynamometer.
Beteende: Control Rest
Seated rest condition without exercise, used as a control comparison to the isometric handgrip intervention.
Övrig: Hypertensive Pregnant Women
Pregnant women with chronic untreated hypertension. Participants in this arm complete both the isometric handgrip exercise session and the control rest session in randomized order.
Beteende: Isometric Handgrip Exercise
Isometric handgrip exercise performed at 30% of maximal voluntary contraction, consisting of four 2-minute contractions with one-minute rest intervals between efforts. The exercise is performed using a handgrip dynamometer.
Beteende: Control Rest
Seated rest condition without exercise, used as a control comparison to the isometric handgrip intervention.

Vad mäter studien?

Primära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
Systoliskt och diastoliskt blodtryck (ambulatorisk blodtrycksmätning)
Tidsram: Efter sessioner (24 timmar)
Hypotoni efter träning, med hjälp av Mobil-O-Graph (mmHg).
Efter sessioner (24 timmar)

Sekundära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
Systolic and diastolic blood pressure (resting)
Tidsram: Before and after sessions (15 minutes)
Automated oscillometric tensiometer (mmHg)
Before and after sessions (15 minutes)
Central blood pressure
Tidsram: Baseline and post-intervention during sessions (30 minutes)
Central systolic and diastolic blood pressure assessed using pulse wave analysis derived from brachial oscillometric measurements.
Baseline and post-intervention during sessions (30 minutes)
Pulse wave velocity
Tidsram: Baseline
Arterial stiffness assessed by carotid-femoral pulse wave velocity using applanation tonometry. This measurement is performed at rest to characterize vascular health.
Baseline
Heart rate
Tidsram: Basline, before and after sessions (15 minutes)
Heart rate measured during each experimental session and recovery period using a heart rate monitor to assess cardiovascular response to the intervention.
Basline, before and after sessions (15 minutes)
Cognitive Performance
Tidsram: Baseline

Cognitive performance assessed at rest using a neuropsychological test battery including executive function, memory, attention, and processing speed tests. This outcome is used to compare cognitive function between normotensive and hypertensive pregnant women.

  • Stroop : higher scores indicate better executive function and inhibitory control. No universal minimum or maximum score.
  • Verbal Fluency Test: higher scores indicate better verbal executive functioning. No universal maximum score.
  • Rey Auditory Verbal Learning Test (RAVLT): Higher scores indicate better verbal learning and memory. Minimum score = 0; maximum score = 75.
  • Digit Span Test (forward and backward): higher scores indicate better working memory and attention. Minimum score = 0; No universal maximum score.
Baseline

Samarbetspartners och utredare

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Sponsor

University of Poitiers

Samarbetspartners

Poitiers University Hospital
Laboratory MOVE, Faculty of Sport Sciences, University of Poitiers, France

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Faktisk)

6 mars 2026

Primärt slutförande (Beräknad)

31 augusti 2027

Avslutad studie (Beräknad)

30 september 2027

Studieregistreringsdatum

Först inskickad

6 maj 2026

Först inskickad som uppfyllde QC-kriterierna

21 maj 2026

Första postat (Faktisk)

26 maj 2026

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)

26 maj 2026

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

21 maj 2026

Senast verifierad

1 maj 2026

Mer information

Termer relaterade till denna studie

Nyckelord

Ytterligare relevanta MeSH-villkor

Andra studie-ID-nummer

  • 2025-A00590-49

Plan för individuella deltagardata (IPD)

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NEJ

Läkemedels- och apparatinformation, studiedokument

Studerar en amerikansk FDA-reglerad läkemedelsprodukt

Nej

Studerar en amerikansk FDA-reglerad produktprodukt

Nej

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