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化疗加放疗治疗 II 期或 III 期肛门癌患者

2016年12月30日更新者：Radiation Therapy Oncology Group

5-氟尿嘧啶、丝裂霉素 C 和放疗与 5-氟尿嘧啶、顺铂和放疗治疗肛管癌的 III 期随机研究

基本原理：化疗中使用的药物使用不同的方法来阻止肿瘤细胞分裂，从而使它们停止生长或死亡。结合一种以上的药物或将放疗与化疗结合可能会杀死更多的肿瘤细胞。目前尚不清楚氟尿嘧啶和丝裂霉素联合放疗是否比氟尿嘧啶和顺铂联合放疗对肛门癌更有效。

目的：这项随机 III 期试验正在研究氟尿嘧啶和丝裂霉素联合放疗，以了解与氟尿嘧啶和顺铂联合放疗相比，它在治疗 II 期或 III 期肛门癌患者方面的效果如何。

研究概览

地位

完全的

条件

肛门癌

干预/治疗

详细说明

目标：

比较接受氟尿嘧啶 (5-FU) 加丝裂霉素同时放疗或先用 5-FU 加顺铂然后再用 5-FU 加顺铂同时放疗的肛管癌患者的初始和总局部和远处失败率。
确定接受这些方案治疗的患者在 2 年时局部控制率和结肠造口率的任何差异。
确定接受这些方案治疗的患者在无结肠造口术、无病生存或总生存方面的任何差异。
比较这些方案对这些患者的毒性作用。
评估肿瘤标志物 P53 过表达、人乳头瘤病毒状态和 HAP1 酶对接受这些方案治疗的患者的预后影响。

大纲：这是一项随机研究。根据性别、淋巴结状态（阳性与阴性）和原发肿瘤大小（大于 2 cm 至 5 cm 与大于 5 cm）对患者进行分层。患者被随机分配到 2 个治疗组中的 1 个。

第 I 组：患者从第 1 天和第 29 天开始连续 96 小时接受氟尿嘧啶 (5-FU) 静脉注射，并在第 1 天和第 29 天接受丝裂霉素静脉注射，同时进行放疗。
第 II 组：患者接受诱导化疗，包括从第 1、29、57 和 85 天开始持续超过 96 小时的 5-FU IV 以及在第 1、29、57 和 85 天超过 1 小时的顺铂 IV。从第 57 天开始，患者接受同步放疗。

在两组中，放射治疗每天进行，每周 5 天，持续 5-6.5 周。患有 T3、T4 或 N+ 病灶或具有残留病灶的 T2 病灶的患者接受额外的放疗以缩小视野。

患者每 3 个月随访 1 年，每 6 个月随访 1 年，之后每年随访一次。

预计应计：在 5 年内，这项研究将总共招募 650 名患者。

研究类型

介入性

注册 (实际的)

682

阶段

第三阶段

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

南非
- - Pretoria, 0001、南非
    - Pretoria Academic Hospital
美国
- Alabama
  - Birmingham、Alabama、美国、35294
    - Comprehensive Cancer Center at University of Alabama at Birmingham
  - Mobile、Alabama、美国、36607
    - Mobile Infirmary Medical Center
- Alaska
  - Anchorage、Alaska、美国、99508
    - Providence Alaska Medical Center
  - Anchorage、Alaska、美国、99508
    - Alaska Regional Hospital
- Arizona
  - Phoenix、Arizona、美国、85013
    - Foundation for Cancer Research and Education
  - Scottsdale、Arizona、美国、85259
    - CCOP - Mayo Clinic Scottsdale Oncology Program
- Arkansas
  - Ft. Smith、Arkansas、美国、72903
    - Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
- California
  - Berkeley、California、美国、94705
    - Alta Bates Comprehensive Cancer Center
  - Burbank、California、美国、91505
    - Providence Saint Joseph Medical Center - Burbank
  - Burlingame、California、美国、94010
    - Mills-Peninsula Health Services
  - Concord、California、美国、94520
    - Mount Diablo Regional Cancer Center
  - Duarte、California、美国、91010
    - City of Hope Comprehensive Cancer Center
  - Fresno、California、美国、93720
    - California Cancer Center - Woodward Park Office
  - Greenbrae、California、美国、94904
    - Sutter Health Western Division Cancer Research Group
  - Greenbrae、California、美国、94904
    - Marin Cancer Institute at Marin General Hospital
  - Hayward、California、美国、94545
    - Saint Rose Hospital
  - Livermore、California、美国、94550
    - Valley Memorial Hospital
  - Loma Linda、California、美国、92354
    - Loma Linda University Cancer Institute at Loma Linda University Medical Center
  - Los Angeles、California、美国、90033-0804
    - USC/Norris Comprehensive Cancer Center and Hospital
  - Mission Hills、California、美国、91346-9600
    - Providence Holy Cross Cancer Center
  - Modesto、California、美国、95355
    - Memorial Medical Center Cancer Services
  - Northridge、California、美国、91325
    - Leavey Cancer Center at Northridge Hospital Medical Center
  - Oakland、California、美国、94602
    - Highland General Hospital
  - Oakland、California、美国、94609
    - CCOP - Bay Area Tumor Institute
  - Oakland、California、美国、94609
    - Summit Medical Center
  - Palo Alto、California、美国、94301
    - Palo Alto Medical Foundation
  - Pomona、California、美国、91767
    - Pomona Valley Hospital Medical Center
  - Sacramento、California、美国、95817
    - University of California Davis Cancer Center
  - Sacramento、California、美国、95815
    - Radiological Associates of Sacramento Medical Group, Inc.
  - San Diego、California、美国、92134
    - Naval Medical Center - San Diego
  - San Francisco、California、美国、94118
    - California Pacific Medical Center - California Campus
  - San Pablo、California、美国、94806
    - J.C. Robinson, M.D. Regional Cancer Center
  - Sana Rosa、California、美国、95405
    - CCOP - Santa Rosa Memorial Hospital
  - Torrance、California、美国、90509
    - Torrance Memorial Medical Center
  - Vallejo、California、美国、94589
    - Sutter Solano Medical Center
- Colorado
  - Aurora、Colorado、美国、80012
    - Aurora Presbyterian Hospital
  - Boulder、Colorado、美国、80301
    - Boulder Community Hospital
  - Colorado Springs、Colorado、美国、80909
    - Memorial Hospital Cancer Center
  - Colorado Springs、Colorado、美国、80933
    - Penrose Cancer Center at Penrose Hospital
  - Denver、Colorado、美国、80210
    - Porter Adventist Hospital
  - Denver、Colorado、美国、80220
    - Rose Medical Center
  - Denver、Colorado、美国、80218
    - Presbyterian - St. Luke's Medical Center
  - Denver、Colorado、美国、80218
    - St. Joseph Hospital
  - Denver、Colorado、美国、80224-2522
    - CCOP - Colorado Cancer Research Program, Incorporated
  - Englewood、Colorado、美国、80110
    - Swedish Medical Center
  - Fort Collins、Colorado、美国、80524
    - Front Range Cancer Specialists
  - Grand Junction、Colorado、美国、81502
    - St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
  - Lone Tree、Colorado、美国、80124
    - Sky Ridge Medical Center
  - Longmont、Colorado、美国、80502
    - Hope Cancer Care Center at Longmont United Hospital
  - Pueblo、Colorado、美国、81004
    - St. Mary-Corwin Regional Medical Center
  - Thorton、Colorado、美国、80229
    - North Suburban Medical Center
- Connecticut
  - Middletown、Connecticut、美国、06457
    - Middlesex Hospital Cancer Center
- Delaware
  - Lewes、Delaware、美国、19958
    - Beebe Medical Center
  - Newark、Delaware、美国、19718
    - CCOP - Christiana Care Health Services
  - Wilmington、Delaware、美国、19805
    - St. Francis Hospital
- District of Columbia
  - Washington、District of Columbia、美国、20007
    - Lombardi Cancer Center at Georgetown University Medical Center
- Florida
  - Fort Lauderdale、Florida、美国、33308
    - Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
  - Fort Myers、Florida、美国、33901
    - 21st Century Oncology - Fort Myers
  - Hollywood、Florida、美国、33021
    - Memorial Cancer Institute at Memorial Regional Hospital
  - Jacksonville、Florida、美国、32207
    - Baptist Cancer Institute - Jacksonville
  - Jacksonville、Florida、美国、32224-9980
    - Mayo Clinic - Jacksonville
  - Jupiter、Florida、美国、33458
    - Ella Milbank Foshay Cancer Center at Jupiter Medical Center
  - Miami、Florida、美国、33136
    - University of Miami Sylvester Comprehensive Cancer Center
  - Miami、Florida、美国、33176
    - Baptist-South Miami Regional Cancer Program
  - Miami Beach、Florida、美国、33140
    - CCOP - Mount Sinai Medical Center
  - Panama City、Florida、美国、32405
    - Gulf Coast Cancer Treatment Center
  - Tallahassee、Florida、美国、32308
    - Tallahassee Memorial Hospital
  - Tampa、Florida、美国、33612
    - H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
- Georgia
  - Altanta、Georgia、美国、30322
    - Emory University Hospital - Atlanta
  - Gainesville、Georgia、美国、30501
    - Northeast Georgia Medical Center
  - Valdosta、Georgia、美国、31603
    - Pearlman Comprehensive Cancer Center at South Georgia Medical Center
- Idaho
  - Boise、Idaho、美国、83706
    - Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
  - Boise、Idaho、美国、83712
    - Mountain States Tumor Institute - Boise
- Illinois
  - Alton、Illinois、美国、62002
    - Saint Anthony's Hospital at Saint Anthony's Health Center
  - Arlington Heights、Illinois、美国、60005
    - Northwest Community Hospital
  - Aurora、Illinois、美国、60507
    - Rush-Copley Cancer Care Center
  - Barrington、Illinois、美国、60010
    - Good Shepherd Hospital
  - Bloomington、Illinois、美国、61701
    - St. Joseph Medical Center
  - Canton、Illinois、美国、61520
    - Graham Hospital
  - Carthage、Illinois、美国、62321
    - Memorial Hospital
  - Chicago、Illinois、美国、60611
    - Robert H. Lurie Comprehensive Cancer Center at Northwestern University
  - Chicago、Illinois、美国、60657
    - Creticos Cancer Center at Advocate Illinois Masonic Medical Center
  - Downers Grove、Illinois、美国、60515
    - Cancer Care Center at Advocate Good Samaritan Hospital
  - Effingham、Illinois、美国、62401
    - St. Anthony's Memorial Hospital
  - Eureka、Illinois、美国、61530
    - Eureka Hospital
  - Evanston、Illinois、美国、60201
    - Evanston Northwestern Health Care - Evanston Hospital
  - Galesburg、Illinois、美国、61401
    - Galesburg Cottage Hospital
  - Galesburg、Illinois、美国、61401
    - Galesburg Clinic
  - Galesburg、Illinois、美国、61401
    - InterCommunity Cancer Center of Western Illinois
  - Havana、Illinois、美国、62644
    - Mason District Hospital
  - Hinsdale、Illinois、美国、60521
    - Hinsdale Hematology Oncology Associates
  - Hopedale、Illinois、美国、61747
    - Hopedale Medical Complex
  - Joliet、Illinois、美国、60435
    - Joliet Oncology Hematology Associates, Limited - West
  - Kewanee、Illinois、美国、61443
    - Kewanee Hospital
  - Macomb、Illinois、美国、61455
    - Mcdonough District Hospital
  - Naperville、Illinois、美国、60566
    - Edward Hospital Cancer Center
  - Normal、Illinois、美国、61761
    - Bromenn Regional Medical Center
  - Normal、Illinois、美国、61761
    - Community Cancer Center
  - Ottawa、Illinois、美国、61350
    - Community Hospital of Ottawa
  - Ottawa、Illinois、美国、61350
    - Oncology Hematology Associates of Central Illinois - Ottawa
  - Park Ridge、Illinois、美国、60068
    - Lutheran General Cancer Care Center
  - Pekin、Illinois、美国、61554
    - Cancer Treatment Center at Pekin Hospital
  - Peoria、Illinois、美国、61614
    - Proctor Hospital
  - Peoria、Illinois、美国、61603
    - Methodist Medical Center of Illinois
  - Peoria、Illinois、美国、61637
    - OSF St. Francis Medical Center
  - Peoria、Illinois、美国、61615
    - CCOP - Illinois Oncology Research Association
  - Peoria、Illinois、美国、61615
    - Oncology/Hematology Associates of Central Illinois, P.C.
  - Peru、Illinois、美国、61354
    - Illinois Valley Community Hospital
  - Princeton、Illinois、美国、61356
    - Perry Memorial Hospital
  - Rockford、Illinois、美国、61104
    - Swedish American Hospital
  - Spring Valley、Illinois、美国、61362
    - St. Margaret's Hospital
  - Spring Valley、Illinois、美国、61362
    - Valley Cancer Center
  - Urbana、Illinois、美国、61801
    - Carle Cancer Center at Carle Foundation Hospital
  - Urbana、Illinois、美国、61801
    - CCOP - Carle Cancer Center
- Indiana
  - Beech Grove、Indiana、美国、46107
    - St. Francis Hospital and Health Centers
  - Bloomington、Indiana、美国、47403
    - Bloomington Hospital
  - Elkhart、Indiana、美国、46515
    - Elkhart General Hospital
  - La Porte、Indiana、美国、46350
    - Center for Cancer Therapy at LaPorte Hospital and Health Services
  - Michigan City、Indiana、美国、46360
    - Saint Anthony Memorial Health Centers
  - Muncie、Indiana、美国、47303
    - Cancer Center at Ball Memorial Hospital
  - Plymouth、Indiana、美国、46544
    - Saint Joseph Regional Medical Center - Plymouth Campus
  - South Bend、Indiana、美国、46601
    - Memorial Hospital of South Bend
  - South Bend、Indiana、美国、46601
    - CCOP - Northern Indiana CR Consortium
  - Terre Haute、Indiana、美国、47804
    - Union Hospital
- Iowa
  - Ames、Iowa、美国、50010
    - McFarland Clinic, P.C.
  - Carroll、Iowa、美国、51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids、Iowa、美国、52402
    - St. Luke's Hospital
  - Cedar Rapids、Iowa、美国、52403
    - Cedar Rapids Oncology Associates
  - Cedar Rapids、Iowa、美国、52403
    - Mercy Cancer Center at Mercy Medical Center
  - Council Bluffs、Iowa、美国、51503
    - Alegent Health Mercy Hospital
  - Davenport、Iowa、美国、52804
    - Genesis Medical Center - West Campus
  - Davenport、Iowa、美国、52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines、Iowa、美国、50309
    - CCOP - Iowa Oncology Research Association
  - Des Moines、Iowa、美国、50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines、Iowa、美国、50309
    - Medical Oncology and Hematology Associates at John Stoddard Cancer Center
  - Des Moines、Iowa、美国、50314
    - Medical Oncology and Hematology Associates at Mercy Cancer Center
  - Des Moines、Iowa、美国、50314
    - Mercy Cancer Center at Mercy Medical Center - Des Moines
  - Des Moines、Iowa、美国、50316
    - John Stoddard Cancer Center at Iowa Lutheran Hospital
  - Des Moines、Iowa、美国、50307
    - Mercy Capitol Hospital
  - Dubuque、Iowa、美国、52001
    - Wendt Regional Cancer Center at Finley Hospital
  - Iowa City、Iowa、美国、52242
    - Holden Comprehensive Cancer Center at University of Iowa
  - Mason City、Iowa、美国、50401
    - Mercy Cancer Center at Mercy Medical Center - North Iowa
  - Missouri Valley、Iowa、美国、51555
    - Alegent Health Community Memorial Hospital
  - Onawa、Iowa、美国、51040
    - Burgess Health Center
  - Sioux City、Iowa、美国、51104
    - St. Luke's Regional Medical Center
  - Sioux City、Iowa、美国、51104
    - Mercy Medical Center - Sioux City
  - Sioux City、Iowa、美国、51101
    - Siouxland Hematology-Oncology Associates
  - West Des Moines、Iowa、美国、50266
    - Medical Oncology and Hematology Associates - West Des Moines
- Kansas
  - Arkansas City、Kansas、美国、67005
    - South Central Kansas Regional Medical Center
  - Chanute、Kansas、美国、66720
    - Cancer Center of Kansas - Chanute
  - Dodge City、Kansas、美国、67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado、Kansas、美国、67042
    - Cancer Center of Kansas, P.A. - El Dorado
  - Kansas City、Kansas、美国、66160
    - Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
  - Kingman、Kansas、美国、67068
    - Cancer Center of Kansas - Kingman
  - Liberal、Kansas、美国、67901
    - Southwest Medical Center
  - Newton、Kansas、美国、67114
    - Cancer Center of Kansas - Newton
  - Ottawa、Kansas、美国、66067
    - Cancer Center of Kansas - Ottawa
  - Parsons、Kansas、美国、67357
    - Cancer Center of Kansas, P.A. - Parsons
  - Pratt、Kansas、美国、67124
    - Pratt Cancer Center of Kansas
  - Salina、Kansas、美国、67042
    - Cancer Center of Kansas - Salina
  - Wellington、Kansas、美国、67152
    - Cancer Center of Kansas - Wellington
  - Wichita、Kansas、美国、67214
    - Wesley Medical Center
  - Wichita、Kansas、美国、67214
    - CCOP - Wichita
  - Wichita、Kansas、美国、67214
    - Via Christi Cancer Center at Via Christi Regional Medical Center
  - Wichita、Kansas、美国、67203
    - Associates In Womens Health
  - Wichita、Kansas、美国、67208
    - Cancer Center of Kansas, P.A.
  - Wichita、Kansas、美国、67214
    - Cancer Center of Kansas, P.A. - Wichita
  - Winfield、Kansas、美国、67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Bowling Green、Kentucky、美国、42101
    - Cancer Treatment Center at the Medical Center - Bowling Green
  - Lexington、Kentucky、美国、40536
    - Markey Cancer Center at University of Kentucky Chandler Medical Center
  - Lexington、Kentucky、美国、40503
    - Central Baptist Hospital
  - Madisonville、Kentucky、美国、42431
    - Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County
- Louisiana
  - Monroe、Louisiana、美国、71210
    - Louisiana State University Health Sciences Center - Monroe
  - New Orleans、Louisiana、美国、70112
    - Tulane Cancer Center
  - Shreveport、Louisiana、美国、71101
    - Veterans Affairs Medical Center - Shreveport
  - Shreveport、Louisiana、美国、71130
    - Feist-Weiller Cancer Center at Louisiana State University Health Sciences
- Maine
  - Bangor、Maine、美国、04401
    - CancerCare of Maine at Eastern Maine Medial Center
  - Lewiston、Maine、美国、04240
    - Central Maine Medical Center
  - Waterville、Maine、美国、04901
    - Maine General Medical Center - Waterville
- Maryland
  - Annapolis、Maryland、美国、21401
    - DeCesaris Cancer Institute at Anne Arundel Medical Center
  - Baltimore、Maryland、美国、21287-8936
    - Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  - Elkton MD、Maryland、美国、21921
    - Union Hospital Cancer Center at Union Hospital
- Massachusetts
  - Boston、Massachusetts、美国、02115
    - Brigham and Women's Hospital
  - Boston、Massachusetts、美国、02115
    - Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
  - Boston、Massachusetts、美国、02114
    - Massachusetts General Hospital Cancer Center
  - Boston、Massachusetts、美国、02118
    - Cancer Research Center at Boston Medical Center
  - Concord、Massachusetts、美国、01742
    - Bethke Cancer Center at Emerson Hospital
  - Fall River、Massachusetts、美国、02721
    - Hudner Oncology Center at Saint Anne's Hospital
  - Hyannis、Massachusetts、美国、02601
    - Cape Cod Hospital
  - Newton、Massachusetts、美国、02162
    - Newton - Wellesley Hospital
  - Quincy、Massachusetts、美国、02169
    - South Suburban Oncology Center
- Michigan
  - Adrian、Michigan、美国、49221
    - Hickman Cancer Center at Bixby Medical Center
  - Ann Arbor、Michigan、美国、48109
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor、Michigan、美国、48106-0995
    - St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
  - Ann Arbor、Michigan、美国、48100
    - CCOP - Michigan Cancer Research Consortium
  - Battle Creek、Michigan、美国、49017
    - Battle Creek Health System
  - Big Rapids、Michigan、美国、49307
    - Mecosta County General Hospital
  - Detroit、Michigan、美国、48202
    - Josephine Ford Cancer Center at Henry Ford Health System
  - Flint、Michigan、美国、48502
    - Hurley Medical Center
  - Flint、Michigan、美国、48532
    - Genesys Hurley Cancer Institute
  - Flint、Michigan、美国、48532
    - Great Lakes Cancer Institute at McLaren Regional Medical Center
  - Grand Rapids、Michigan、美国、49503
    - CCOP - Grand Rapids
  - Grand Rapids、Michigan、美国、49503
    - Lacks Cancer Center at Saint Mary's Mercy Medical Center
  - Grand Rapids、Michigan、美国、49503
    - Spectrum Health Cancer Care - Butterworth Campus
  - Grand Rapids、Michigan、美国、49506
    - Metropolitan Hospital
  - Grand Rapids、Michigan、美国、49506
    - Spectrum Health Hospital - Blodgett Campus
  - Holland、Michigan、美国、49423
    - Holland Community Hospital
  - Kalamazoo、Michigan、美国、49007
    - West Michigan Cancer Center
  - Kalamazoo、Michigan、美国、49007
    - Bronson Methodist Hospital
  - Kalamazooaa、Michigan、美国、49001
    - Borgess Medical Center
  - Marquette、Michigan、美国、49855
    - Upper Michigan Cancer Center at Marquette General Hospital
  - Muskegon、Michigan、美国、49443
    - Hackley Hospital
  - Petoskey、Michigan、美国、49770
    - Northern Michigan Hospital
  - Port Huron、Michigan、美国、48060
    - Mercy Hospital
  - Saginaw、Michigan、美国、48601
    - Seton Cancer Institute - Saginaw
  - Saint Joseph、Michigan、美国、49085
    - Oncology Care Associates, P.L.L.C.
  - Southfield、Michigan、美国、48075
    - Providence Cancer Institute at Providence Hospital - Southfield Campus
  - Traverse City、Michigan、美国、49684
    - Munson Medical Center
  - Warren、Michigan、美国、48903
    - St. John Macomb Hospital
- Minnesota
  - Bemidji、Minnesota、美国、56601
    - MeritCare Clinic - Bemidji
  - Brainerd、Minnesota、美国、56401
    - Brainerd Medical Center
  - Burnsville、Minnesota、美国、55337
    - Fairview Ridges Hospital
  - Coon Rapids、Minnesota、美国、55433
    - Mercy Hospital
  - Duluth、Minnesota、美国、55805
    - CCOP - Duluth
  - Duluth、Minnesota、美国、55805
    - St. Mary's - Duluth Clinic Cancer Center
  - Duluth、Minnesota、美国、55805
    - Miller-Dwan Medical Center
  - Duluth、Minnesota、美国、55805
    - Cancer Care Center at St. Luke's Hospital
  - Edina、Minnesota、美国、55435
    - Fairview Southdale Hospital
  - Fridley、Minnesota、美国、55432
    - Mercy and Unity Cancer Center at Mercy and Unity Hospitals
  - Hutchinson、Minnesota、美国、55350
    - Hutchinson Area Health Care
  - Litchfield、Minnesota、美国、55355
    - Meeker County Memorial Hospital
  - Maplewood、Minnesota、美国、55109
    - St. John's Hospital
  - Minneapolis、Minnesota、美国、55415
    - Hennepin County Medical Center - Minneapolis
  - Minneapolis、Minnesota、美国、55407
    - Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
  - Minneapolis、Minnesota、美国、55455
    - Fairview University Medical Center - University Campus
  - Montevideo、Minnesota、美国、56265
    - Chippewa County - Montevideo Hospital
  - Robbinsdale、Minnesota、美国、55422
    - Hubert H. Humphrey Cancer Center at North Memorial Medical Center
  - Rochester、Minnesota、美国、55905
    - Mayo Clinic Cancer Center
  - Saint Louis Park、Minnesota、美国、55416
    - CCOP - Metro-Minnesota
  - Saint Paul、Minnesota、美国、55101
    - Cancer Care Center at Regions Hospital
  - Shakopee、Minnesota、美国、55379
    - Saint Francis Cancer Center
  - St Paul、Minnesota、美国、55102
    - St. Joseph's Hospital
  - St. Cloud、Minnesota、美国、56303
    - CentraCare Clinic - River Campus
  - St. Cloud、Minnesota、美国、56303
    - Adult and Pediatric Urology, P.L.L.P.
  - St. Louis Park、Minnesota、美国、55416
    - Park Nicollet Clinic
  - St. Paul、Minnesota、美国、55102
    - United Hospital
  - Waconia、Minnesota、美国、55387
    - Ridgeview Medical Center
  - Willmar、Minnesota、美国、56201
    - Rice Memorial Hospital
  - Woodbury、Minnesota、美国、55125
    - Woodwinds Hospital
- Mississippi
  - Jackson、Mississippi、美国、39216
    - Veterans Affairs Medical Center - Jackson
  - Jackson、Mississippi、美国、39216
    - University of Mississippi Medical Center
  - Pascagoula、Mississippi、美国、39581
    - Regional Cancer Center at Singing River Hospital
- Missouri
  - Cape Girardeau、Missouri、美国、63701
    - St. Francis Medical Center
  - Chesterfield、Missouri、美国、63017
    - Saint Luke's Hospital
  - Columbia、Missouri、美国、65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Columbia、Missouri、美国、65201
    - Missouri Cancer Associates
  - Gape Girardeau、Missouri、美国、63701
    - Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
  - Kansas City、Missouri、美国、64131
    - CCOP - Kansas City
  - Springfield、Missouri、美国、65804
    - St. John's Regional Health Center
  - Springfield、Missouri、美国、65807
    - Hulston Cancer Center at Cox Medical Center South
  - St Louis、Missouri、美国、63110
    - Siteman Cancer Center at Barnes-Jewish Hospital
  - St. Louis、Missouri、美国、63131
    - Missouri Baptist Cancer Center
  - St. Louis、Missouri、美国、63141
    - CCOP - St. Louis-Cape Girardeau
  - St. Louis、Missouri、美国、63141
    - David C. Pratt Cancer Center at St. John's Mercy
  - St. Louis、Missouri、美国、63141
    - Center for Cancer Care and Research
- Montana
  - Billings、Montana、美国、59101
    - CCOP - Montana Cancer Consortium
  - Great Falls、Montana、美国、59405
    - Great Falls Clinic
  - Great Falls、Montana、美国、59405
    - Sletten Regional Cancer Institute
- Nebraska
  - Fremont、Nebraska、美国、68025
    - Fremont Area Medical Center
  - Kearney、Nebraska、美国、68847
    - Cancer Center at the Good Samaritan Health Systems
  - Lincoln、Nebraska、美国、68502
    - Bryan LGH Medical Center West
  - Lincoln、Nebraska、美国、68510
    - Cancer Resource Center - Lincoln
  - Lincoln、Nebraska、美国、68510
    - St. Elizabeth Regional Medical Center
  - Omaha、Nebraska、美国、68106
    - CCOP - Missouri Valley Cancer Consortium
  - Omaha、Nebraska、美国、68114
    - Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
  - Omaha、Nebraska、美国、68124
    - Bergan Mercy Medical Center
  - Omaha、Nebraska、美国、68122
    - Alegent Health - Immanuel Medical Center
  - Omaha、Nebraska、美国、68131
    - Cancer Center at Creighton University Medical Center
  - Papillion、Nebraska、美国、68046
    - Midlands Cancer Center at Midlands Community Hospital
- Nevada
  - Las Vegas、Nevada、美国、89106
    - CCOP - Southern Nevada Cancer Research Foundation
  - Las Vegas、Nevada、美国、89109
    - Sunrise Hospital and Medical Center
  - Las Vegas、Nevada、美国、89102
    - University Medical Center of Southern Nevada
  - Reno、Nevada、美国、89502
    - Washoe Cancer Services at Washoe Medical Center - Reno
- New Hampshire
  - Lebanon、New Hampshire、美国、03756
    - Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
- New Jersey
  - Camden、New Jersey、美国、08103
    - Cancer Institute of New Jersey at the Cooper University Hospital
  - Hackensack、New Jersey、美国、07601
    - CCOP - Northern New Jersey
  - Long Branch、New Jersey、美国、07740
    - Monmouth Medical Center
  - Millville、New Jersey、美国、08332
    - South Jersey Healthcare Regional Cancer Center
  - Montclair、New Jersey、美国、07042
    - Cancer Center at the Mountainside Hospital
  - Mount Holly、New Jersey、美国、08060
    - Fox Chase Virtua Health Cancer Program - Marlton
  - Newark、New Jersey、美国、07112
    - Newark Beth Israel Medical Center
  - Pomona、New Jersey、美国、08240
    - Atlantic City Medical Center - Mainland Division
  - Red Bank、New Jersey、美国、07701
    - Booker Cancer Center at Riverview Medical Center
  - Toms River、New Jersey、美国、08755
    - Community Medical Center
  - Trenton、New Jersey、美国、08611
    - Fox Chase Cancer Center at St. Francis Medical Center
  - Trenton、New Jersey、美国、08618
    - Capital Health System Regional Cancer Center
- New Mexico
  - Albuquerque、New Mexico、美国、87106
    - University of New Mexico Cancer Research and Treatment Center
  - Albuquerque、New Mexico、美国、87108
    - Lovelace Medical Center at Lovelace Sandia Health System
  - Albuquerque、New Mexico、美国、87106
    - Hematology-Oncology Associates, PC
- New York
  - Brooklyn、New York、美国、11203
    - SUNY Downstate Medical Center
  - Brooklyn、New York、美国、11215
    - New York Methodist Hospital
  - Clifton Springs、New York、美国、14432
    - Finger Lakes Hematology and Oncology
  - Cooperstown、New York、美国、13326
    - Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital
  - Harris、New York、美国、12742
    - Catskill Regional Medical Center
  - Manhasset、New York、美国、11030
    - CCOP - North Shore University Hospital
  - New York、New York、美国、10021
    - New York Weill Cornell Cancer Center at Cornell University
  - Rochester、New York、美国、14642
    - James P. Wilmot Cancer Center at University of Rochester Medical Center
  - Rochester、New York、美国、14620
    - Highland Hospital of Rochester
  - Syracuse、New York、美国、13210
    - Veterans Affairs Medical Center - Syracuse
  - Syracuse、New York、美国、13057
    - CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
  - Syracuse、New York、美国、13215
    - Community General Hospital of Greater Syracuse
  - Syracuse、New York、美国、13210
    - Crouse Hospital
- North Carolina
  - Asheboro、North Carolina、美国、27203
    - Randolph Hospital
  - Charlotte、North Carolina、美国、28233
    - Presbyterian Cancer Center at Presbyterian Hospital
  - Charlotte、North Carolina、美国、28203
    - Blumenthal Cancer Center at Carolinas Medical Center
  - Eden、North Carolina、美国、27288
    - John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital
  - Goldsboro、North Carolina、美国、27534
    - Wayne Radiation Oncology
  - Goldsboro、North Carolina、美国、27534
    - Wayne Memorial Hospital, Incorporated
  - Greensboro、North Carolina、美国、27401
    - Moses Cone Regional Cancer Center at Wesley Long Community Hospital
  - Kinston、North Carolina、美国、28501
    - Lenoir Memorial Cancer Center
  - Reidsville、North Carolina、美国、27320
    - Annie Penn Cancer Center
  - Wilmington、North Carolina、美国、28401
    - Zimmer Cancer Center at New Hanover Regional Medical Center
  - Wilson、North Carolina、美国、27893
    - Wilson Medical Center
  - Winston-Salem、North Carolina、美国、27103
    - Forsyth Regional Cancer Center at Forsyth Medical Center
- North Dakota
  - Bismarck、North Dakota、美国、58501
    - Medcenter One Health System
  - Bismarck、North Dakota、美国、58501
    - Mid Dakota Clinic, P.C.
  - Bismarck、North Dakota、美国、58501
    - Bismarck Cancer Center
  - Bismarck、North Dakota、美国、58501
    - St. Alexius Medical Center
  - Fargo、North Dakota、美国、58122
    - CCOP - MeritCare Hospital
  - Fargo、North Dakota、美国、58122
    - MeritCare Medical Group
  - Grand Forks、North Dakota、美国、58201
    - Altru Cancer Center at Altru Hospital
  - Minot、North Dakota、美国、58701
    - Trinity Cancer Care Center
- Ohio
  - Akron、Ohio、美国、44307
    - McDowell Cancer Center at Akron General Medical Center
  - Akron、Ohio、美国、44304
    - Akron City Hospital at Summa Health System
  - Canton、Ohio、美国、44708
    - University Hospitals Ireland Cancer Center at Mercy Medical Center
  - Chillicothe、Ohio、美国、54601
    - Adena Regional Medical Center
  - Cleveland、Ohio、美国、44195
    - Cleveland Clinic Taussig Cancer Center
  - Cleveland、Ohio、美国、44109
    - MetroHealth's Cancer Care Center at MetroHealth Medical Center
  - Cleveland、Ohio、美国、44106
    - Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University
  - Cleveland、Ohio、美国、44112
    - Huron Hospital Cancer Care Center
  - Cleveland、Ohio、美国、44119
    - Euclid Hospital
  - Columbus、Ohio、美国、43215
    - CCOP - Columbus
  - Columbus、Ohio、美国、43228
    - Doctors Hospital at Ohio Health
  - Columbus、Ohio、美国、43214
    - Riverside Methodist Hospital Cancer Care
  - Columbus、Ohio、美国、43215
    - Grant Riverside Cancer Services
  - Columbus、Ohio、美国、43222
    - Mount Carmel West Hospital
  - Columbus、Ohio、美国、43210
    - Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
  - Dayton、Ohio、美国、45428
    - Veterans Affairs Medical Center - Dayton
  - Dayton、Ohio、美国、45409
    - Miami Valley Hospital
  - Dayton、Ohio、美国、45405
    - Grandview Hospital
  - Dayton、Ohio、美国、45406
    - Good Samaritan Hospital
  - Dayton、Ohio、美国、45415
    - Samaritan North Cancer Care Center
  - Dayton、Ohio、美国、45429
    - CCOP - Dayton
  - Delaware、Ohio、美国、43015
    - Grady Memorial Hospital
  - Kettering、Ohio、美国、45429
    - Charles F. Kettering Memorial Hospital
  - Lancaster、Ohio、美国、43130
    - Fairfield Medical Center
  - Lima、Ohio、美国、45804
    - Lima Memorial Hospital
  - Lima、Ohio、美国、45801
    - St. Rita's Medical Center
  - Marietta、Ohio、美国、45750
    - Strecker Cancer Center at Marietta Memorial Hospital
  - Maumee、Ohio、美国、43537
    - St. Luke's Hospital
  - Mayfield Heights、Ohio、美国、44124
    - Hillcrest Cancer Center at Hillcrest Hospital
  - Middletown、Ohio、美国、45044
    - Middletown Regional Hospital
  - Newark、Ohio、美国、43055
    - Licking Memorial Cancer Care Program at Licking Memorial Hospital
  - Oregon、Ohio、美国、43616
    - St. Charles Mercy Hospital
  - Salem、Ohio、美国、44460
    - Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford
  - Sandusky、Ohio、美国、44870
    - Firelands Regional Medical Center
  - Springfield、Ohio、美国、45505
    - Community Hospital of Springfield and Clark County
  - Springfield、Ohio、美国、45504
    - Mercy Medical Center Oncology Unit
  - Sylvania、Ohio、美国、43560
    - Promedica Cancer Center at Flower Hospital
  - Tiffin、Ohio、美国、44883
    - Mercy Hospital of Tiffin
  - Toledo、Ohio、美国、43608
    - St. Vincent Mercy Medical Center
  - Toledo、Ohio、美国、43606
    - Toledo Hospital
  - Toledo、Ohio、美国、43623
    - CCOP - Toledo Community Hospital
  - Toledo、Ohio、美国、43614
    - Medical College of Ohio Cancer Institute
  - Toledo、Ohio、美国、43623
    - Toledo Clinic, Incorporated
  - Troy、Ohio、美国、45373
    - UVMC Cancer Care Center at Upper Valley Medical Center
  - Warrensville Heights、Ohio、美国、44122
    - South Pointe Hospital Cancer Care Center
  - Westerville、Ohio、美国、43081
    - Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital
  - Wooster、Ohio、美国、44691
    - Cancer Treatment Center
  - Xenia、Ohio、美国、45385
    - Ruth G. McMillan Cancer Center at Greene Memorial Hospital
  - Zanesville、Ohio、美国、43701
    - Genesis - Good Samaritan Hospital
- Oklahoma
  - Tulsa、Oklahoma、美国、74136
    - Natalie Warren Bryant Cancer Center at St. Francis Hospital
  - Tulsa、Oklahoma、美国、74104
    - LaFortune Cancer Center at St. John Health System
- Oregon
  - Glesham、Oregon、美国、97030
    - Legacy Mount Hood Medical Center
  - Milwaukie、Oregon、美国、97222
    - Providence Milwaukie Hospital
  - Portland、Oregon、美国、97225
    - CCOP - Columbia River Oncology Program
  - Portland、Oregon、美国、97225
    - Providence St. Vincent Medical Center
  - Portland、Oregon、美国、97210
    - Comprehensive Cancer Center at Legacy Good Samaritan Hospital & Medical Center
  - Portland、Oregon、美国、97213
    - Providence Cancer Center at Providence Portland Medical Center
  - Portland、Oregon、美国、97227
    - Institute of Oncology at Vilnius University
  - Portland、Oregon、美国、97232
    - Kaiser Permanente Health Care - Portland
  - Portland、Oregon、美国、97239
    - Cancer Institute at Oregon Health and Science University
  - Salem、Oregon、美国、97309
    - Salem Hospital Regional Cancer Center
  - Tualatin、Oregon、美国、97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Allentown、Pennsylvania、美国、18105
    - John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
  - Bethlehem、Pennsylvania、美国、18015
    - St. Luke's Hospital Cancer Center
  - Bryn Mawr、Pennsylvania、美国、19010
    - Bryn Mawr Hospital
  - Danville、Pennsylvania、美国、17822-2001
    - Geisinger Medical Center
  - Drexel Hill、Pennsylvania、美国、19026
    - Delaware County Regional Cancer Center at Delaware County Memorial Hospital
  - Hershey、Pennsylvania、美国、17033-0850
    - Penn State Cancer Institute at Milton S. Hershey Medical Center
  - Langhorne、Pennsylvania、美国、19047
    - St. Mary Regional Cancer Center
  - Lewistown、Pennsylvania、美国、17044
    - Lewistown Hospital
  - Paoli、Pennsylvania、美国、19301
    - Cancer Center at Paoli Memorial Hospital
  - Philadelphia、Pennsylvania、美国、19111-2497
    - Fox Chase Cancer Center
  - Philadelphia、Pennsylvania、美国、19141
    - Albert Einstein Cancer Center
  - Philadelphia、Pennsylvania、美国、19107
    - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
  - Philadelphia、Pennsylvania、美国、19107
    - Joan Karnell Cancer Center at Pennsylvania Hospital
  - Pittsburgh、Pennsylvania、美国、15212
    - Allegheny Cancer Center at Allegheny General Hospital
  - Pittsburgh、Pennsylvania、美国、15219
    - Mercy Hospital of Pittsburgh
  - Pittsburgh、Pennsylvania、美国、15224-1791
    - Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
  - Pottstown、Pennsylvania、美国、19464
    - Pottstown Memorial Regional Cancer Center
  - Reading、Pennsylvania、美国、19604
    - St. Joseph Medical Center
  - Sayre、Pennsylvania、美国、18840
    - Guthrie Medical Center - Sayre
  - Scranton、Pennsylvania、美国、18501
    - Mercy Hospital Cancer Center - Scranton
  - State College、Pennsylvania、美国、16801
    - Geisinger Medical Group
  - State College、Pennsylvania、美国、16803
    - Mount Nittany Medical Center
  - West Reading、Pennsylvania、美国、19612
    - Reading Hospital and Medical Center
  - Wilkes-Barre、Pennsylvania、美国、18711
    - Geisinger Wyoming Valley Medical Center
  - Wynnewood、Pennsylvania、美国、19096
    - CCOP - MainLine Health
  - Wynnewood、Pennsylvania、美国、19096
    - Lankenau Cancer Center at Lankenau Hospital
- South Carolina
  - Greenville、South Carolina、美国、29615
    - CCOP - Greenville
  - Greenville、South Carolina、美国、29601
    - Bon Secours St. Francis Health System
  - Greenville、South Carolina、美国、29605
    - Greenville Hospital System Cancer Center
- South Dakota
  - Rapid City、South Dakota、美国、57701
    - Rapid City Regional Hospital
  - Sioux Falls、South Dakota、美国、57105
    - Medical X-Ray Center
  - Sioux Falls、South Dakota、美国、57104
    - Sioux Valley Hospital and University of South Dakota Medical Center
  - Sioux Falls、South Dakota、美国、57105
    - Avera McKennan Hospital and University Health Center
- Tennessee
  - Memphis、Tennessee、美国、38146
    - Baptist Centers for Cancer Care
- Texas
  - Amarillo、Texas、美国、79106
    - Harrington Cancer Center
  - Bryan、Texas、美国、77802
    - St. Joseph Regional Cancer Center
  - Fort Sam Houston、Texas、美国、78234
    - Brooke Army Medical Center
  - Houston、Texas、美国、77030
    - M.D. Anderson Cancer Center at University of Texas
  - Lackland AFB、Texas、美国、78236
    - Wilford Hall Medical Center
  - Lubbock、Texas、美国、79410
    - Joe Arrington Cancer Research and Treatment Center
  - San Antonio、Texas、美国、78229
    - Cancer Therapy and Research Center
  - San Antonio、Texas、美国、78209
    - Veterans Affairs Medical Center - San Antonio (Murphy)
  - San Antonio、Texas、美国、78229
    - University Hospital - San Antonio
  - San Antonio、Texas、美国、78284
    - University of Texas Health Science Center at San Antonio
- Utah
  - Murray、Utah、美国、84107
    - Cottonwood Hospital Medical Center
  - Ogden、Utah、美国、84403
    - McKay-Dee Hospital Center
  - Provo、Utah、美国、84603
    - Utah Valley Regional Medical Center - Provo
  - Salt Lake City、Utah、美国、84143
    - LDS Hospital
  - Salt Lake City、Utah、美国、84112
    - Huntsman Cancer Institute at University of Utah
  - Salt Lake City、Utah、美国、84106
    - Utah Cancer Specialists at UCS Cancer Center
  - St. George、Utah、美国、84770
    - Dixie Regional Medical Center
- Vermont
  - Berlin、Vermont、美国、05602
    - Mountainview Medical
  - Burlington、Vermont、美国、05401
    - Fletcher Allen Health Care - University Health Center Campus
- Virginia
  - Danville、Virginia、美国、24541
    - Danville Regional Medical Center
  - Hampton、Virginia、美国、23666
    - Virginia Oncology Associates - Hampton
  - Richmond、Virginia、美国、23226
    - Bon Secours Cancer Care at St. Mary's Hospital
- Washington
  - Bellingham、Washington、美国、98225
    - St. Joseph Hospital Community Cancer Center
  - Bremerton、Washington、美国、98310
    - Olympic Hematology and Oncology
  - Everett、Washington、美国、98201
    - Providence Cancer Institute at Providence Everett Medical Center - Pacific Campus
  - Mt. Vernon、Washington、美国、98273
    - Cancer Care Center at Skagit Valley Hospital
  - Seattle、Washington、美国、98104
    - Harborview Medical Center
  - Seattle、Washington、美国、98101
    - CCOP - Virginia Mason Research Center
  - Seattle、Washington、美国、98104
    - Fred Hutchinson Cancer Research Center
  - Seattle、Washington、美国、98195
    - University Cancer Center at University of Washington Medical Center
  - Seattle、Washington、美国、98104
    - Group Health Central Hospital
  - Seattle、Washington、美国、98114
    - Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
  - Spokane、Washington、美国、99202
    - Cancer Care Northwest - Spokane South
  - Tacoma、Washington、美国、98431
    - Madigan Army Medical Center
  - Vancouver、Washington、美国、98668
    - Cancer Center at Southwest Washington Medical Center
  - Wenatchee、Washington、美国、98801
    - Central Washington Hospital
  - Wenatchee、Washington、美国、98801
    - Wenatchee Valley Clinic
- West Virginia
  - Morgantown、West Virginia、美国、26506
    - Mary Babb Randolph Cancer Center at West Virginia University Hospitals
  - Parkersburg、West Virginia、美国、26101
    - Camden-Clark Memorial Hospital
- Wisconsin
  - Eau Claire、Wisconsin、美国、54702
    - Luther Mildelfort Hospital
  - Eau Claire、Wisconsin、美国、54702
    - Midelfort Clinic - Luther
  - Fond Du Lac、Wisconsin、美国、54935
    - Central Wisconsin Cancer Program at Agnesian Health Care
  - Green Bay、Wisconsin、美国、54303
    - Green Bay Oncology, Limited at St. Mary's Hospital
  - Green Bay、Wisconsin、美国、54301-3526
    - Green Bay Oncology, Limited at St. Vincent Hospital
  - Green Bay、Wisconsin、美国、54301
    - St. Vincent Hospital
  - Green Bay、Wisconsin、美国、54303
    - St. Mary's Hospital Medical Center
  - La Crosse、Wisconsin、美国、54601
    - Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
  - Madison、Wisconsin、美国、53792
    - University of Wisconsin Comprehensive Cancer Center
  - Marinette、Wisconsin、美国、54143
    - Bay Area Cancer Care Center at Bay Area Medical Center
  - Marshfield、Wisconsin、美国、54449
    - Marshfield Clinic - Marshfield Center
  - Menomonee Falls、Wisconsin、美国、53051
    - Community Memorial Hospital
  - Milwaukee、Wisconsin、美国、53295
    - Veterans Affairs Medical Center - Milwaukee (Zablocki)
  - Milwaukee、Wisconsin、美国、53226
    - Medical College of Wisconsin Cancer Center
  - Milwaukee、Wisconsin、美国、53215
    - Vince Lombardi Cancer Clinic at St. Luke's Medical Center
  - Racine、Wisconsin、美国、53405
    - All Saints Cancer Center at All Saints Healthcare
  - West Allis、Wisconsin、美国、53227
    - West Allis Memorial Hospital

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年至 120年 (成人、OLDER_ADULT)

接受健康志愿者

不

有资格学习的性别

全部

描述

疾病特征：

经组织学证实的肛管原发性鳞状细胞癌、基底样癌或泄殖腔癌，原位癌除外
- T2-4，任何 N，M0（II 或 III 期）
局部切除或腹部腹膜切除后无局部或区域复发

患者特征：

年龄：

18岁及以上

性能状态：

卡诺夫斯基 60-100%

预期寿命：

未指定

造血：

白细胞至少 4,000/mm^3
中性粒细胞绝对计数至少 1,800/mm^3
血小板计数至少 100,000/mm^3
血红蛋白至少 10 g/dL

肝脏：

胆红素低于 1.4 mg/dL

肾脏：

肌酐不超过 1.5 mg/dL 或
肌酐清除率至少 80 mL/min

心血管：

无代偿性心脏病
没有不受控制的高血压

其他：

没有艾滋病
无活动性全身感染
没有不受控制的糖尿病
除非黑色素瘤皮肤癌外，过去 5 年内无其他既往恶性肿瘤
没有会妨碍研究参与的精神状况
未怀孕或哺乳
生育患者必须使用有效的避孕措施

先前的同步治疗：

生物疗法：

先前的阿法依泊汀允许代替输血

化疗：

自上次化疗以来至少 5 年

内分泌治疗：

未指定

放疗：

自上次放疗后至少 5 年

外科手术：

除了研究部位的活检外，之前没有做过肛管手术

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

主要用途：治疗
分配：随机化

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Radiation Therapy Oncology Group

合作者

National Cancer Institute (NCI)

Eastern Cooperative Oncology Group

Southwest Oncology Group

Cancer and Leukemia Group B

North Central Cancer Treatment Group

调查人员

学习椅：Joel E. Tepper, MD、UNC Lineberger Comprehensive Cancer Center

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

Ben-Josef E, Moughan J, Ajani JA, Flam M, Gunderson L, Pollock J, Myerson R, Anne R, Rosenthal SA, Willett C. Impact of overall treatment time on survival and local control in patients with anal cancer: a pooled data analysis of Radiation Therapy Oncology Group trials 87-04 and 98-11. J Clin Oncol. 2010 Dec 1;28(34):5061-6. doi: 10.1200/JCO.2010.29.1351. Epub 2010 Oct 18.
Glynne-Jones R, Mawdsley S. Anal cancer: is neoadjuvant cisplatin chemotherapy or chemoradiotherapy friend or foe? Nat Clin Pract Oncol. 2008 Dec;5(12):692-3. doi: 10.1038/ncponc1258. Epub 2008 Oct 14.
Gunderson LL, Winter KA, Ajani JA, et al.: Long-term update of U.S. GI intergroup RTOG 98-11 phase III trial for anal carcinoma: disease-free and overall survival with RT+5FU-mitomycin versus RT+5FU-cisplatin. [Abstract] J Clin Oncol 29 (Suppl 15): A-4005, 2011.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG. Prognostic factors derived from a prospective database dictate clinical biology of anal cancer: the intergroup trial (RTOG 98-11). Cancer. 2010 Sep 1;116(17):4007-13. doi: 10.1002/cncr.25188.
Gunderson LL, Moughan J, Ajani JA, et al.: Anal carcinoma: Impact of TN category of disease on survival, disease relapse, and colostomy failure in U.S. GI Intergroup RTOG 98-11 phase III trial. [Abstract] American Society of Clinical Oncology 2010 Gastrointestinal Cancers Symposium, 22-24 January 2010, Orlando, Florida. A-285, 2010.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG. US intergroup anal carcinoma trial: tumor diameter predicts for colostomy. J Clin Oncol. 2009 Mar 1;27(7):1116-21. doi: 10.1200/JCO.2008.19.6857. Epub 2009 Jan 12.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA. 2008 Apr 23;299(16):1914-21. doi: 10.1001/jama.299.16.1914.
Ajani JA, Winter KA, Gunderson LL, et al.: Intergroup RTOG 98-11: a phase III randomized study of 5-fluorouracil (5-FU), mitomycin, and radiotherapy versus 5-fluorouracil, cisplatin and radiotherapy in carcinoma of the anal canal. [Abstract] J Clin Oncol 24 (Suppl 18): A-4009, 2006.
Gunderson LL, Winter KA, Ajani JA, et al.: Intergroup RTOG 9811 phase III comparison of chemoradiation with 5-FU and mitomycin vs 5-FU and cisplatin for anal canal carcinoma: impact on disease-free, overall and colostomy-free survival. [Abstract] Int J Radiat Oncol Biol Phys 66 (3 Suppl 1): A-43, S24, 2006.
Gunderson LL, Winter KA, Ajani JA, Pedersen JE, Moughan J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG. Long-term update of US GI intergroup RTOG 98-11 phase III trial for anal carcinoma: survival, relapse, and colostomy failure with concurrent chemoradiation involving fluorouracil/mitomycin versus fluorouracil/cisplatin. J Clin Oncol. 2012 Dec 10;30(35):4344-51. doi: 10.1200/JCO.2012.43.8085. Epub 2012 Nov 13.

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

1998年10月1日

初级完成 (实际的)

2005年10月1日

研究完成 (实际的)

2016年12月1日

研究注册日期

首次提交

1999年11月1日

首先提交符合 QC 标准的

2003年1月26日

首次发布 (估计)

2003年1月27日

研究记录更新

最后更新发布 (估计)

2017年1月4日

上次提交的符合 QC 标准的更新

2016年12月30日

最后验证