Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer

December 30, 2016 updated by: Radiation Therapy Oncology Group

A Phase III Randomized Study of 5-Fluorouracil, Mitomycin-C, and Radiotherapy Versus 5-Fluorouracil, Cisplatin, and Radiotherapy in Carcinoma of the Anal Canal

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug or combining radiation therapy with chemotherapy may kill more tumor cells. It is not yet known whether fluorouracil and mitomycin plus radiation therapy is more effective than fluorouracil and cisplatin plus radiation therapy for anal cancer.

PURPOSE: This randomized phase III trial is studying fluorouracil and mitomycin plus radiation therapy to see how well it works compared to fluorouracil and cisplatin plus radiation therapy in treating patients with stage II or stage III anal cancer.

Study Overview

Status

Completed

Conditions

Anal Cancer

Intervention / Treatment

Detailed Description

OBJECTIVES:

Compare the initial and total local and distant failure rates in patients with anal canal cancer treated with either fluorouracil (5-FU) plus mitomycin concurrently with radiotherapy or 5-FU plus cisplatin followed by 5-FU plus cisplatin concurrently with radiotherapy.
Identify any differences in local control and colostomy rates at 2 years in patients treated with these regimens.
Determine any difference in colostomy free, disease free, or overall survival in patients treated with these regimens.
Compare the toxic effects of these regimens in these patients.
Evaluate the prognostic effects of tumor markers P53 overexpression, human papilloma virus status, and enzyme HAP1 in patients treated with these regimens.

OUTLINE: This is a randomized study. Patients are stratified according to gender, nodal status (positive vs negative), and primary tumor size (greater than 2 cm to 5 cm vs greater than 5 cm). Patients are randomized to 1 of 2 treatment arms.

Arm I: Patients receive fluorouracil (5-FU) IV continuously over 96 hours beginning on days 1 and 29 and mitomycin IV on days 1 and 29 with concurrent radiotherapy.
Arm II: Patients receive induction chemotherapy comprising 5-FU IV continuously over 96 hours beginning on days 1, 29, 57, and 85 and cisplatin IV over 1 hour on days 1, 29, 57, and 85. Beginning on day 57, patients receive concurrent radiotherapy.

In both arms, radiotherapy is administered daily, 5 days a week, for 5-6.5 weeks. Patients with T3, T4, or N+ lesions or T2 lesions with residual disease receive additional radiotherapy to a reduced field.

Patients are followed every 3 months for 1 year, every 6 months for 1 year, and then annually thereafter.

PROJECTED ACCRUAL: A total of 650 patients will be accrued for this study within 5 years.

Study Type

Interventional

Enrollment (Actual)

682

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

South Africa
- - Pretoria, 0001, South Africa
    - Pretoria Academic Hospital
United States
- Alabama
  - Birmingham, Alabama, United States, 35294
    - Comprehensive Cancer Center at University of Alabama at Birmingham
  - Mobile, Alabama, United States, 36607
    - Mobile Infirmary Medical Center
- Alaska
  - Anchorage, Alaska, United States, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, United States, 99508
    - Alaska Regional Hospital
- Arizona
  - Phoenix, Arizona, United States, 85013
    - Foundation for Cancer Research and Education
  - Scottsdale, Arizona, United States, 85259
    - CCOP - Mayo Clinic Scottsdale Oncology Program
- Arkansas
  - Ft. Smith, Arkansas, United States, 72903
    - Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
- California
  - Berkeley, California, United States, 94705
    - Alta Bates Comprehensive Cancer Center
  - Burbank, California, United States, 91505
    - Providence Saint Joseph Medical Center - Burbank
  - Burlingame, California, United States, 94010
    - Mills-Peninsula Health Services
  - Concord, California, United States, 94520
    - Mount Diablo Regional Cancer Center
  - Duarte, California, United States, 91010
    - City of Hope Comprehensive Cancer Center
  - Fresno, California, United States, 93720
    - California Cancer Center - Woodward Park Office
  - Greenbrae, California, United States, 94904
    - Sutter Health Western Division Cancer Research Group
  - Greenbrae, California, United States, 94904
    - Marin Cancer Institute at Marin General Hospital
  - Hayward, California, United States, 94545
    - Saint Rose Hospital
  - Livermore, California, United States, 94550
    - Valley Memorial Hospital
  - Loma Linda, California, United States, 92354
    - Loma Linda University Cancer Institute at Loma Linda University Medical Center
  - Los Angeles, California, United States, 90033-0804
    - USC/Norris Comprehensive Cancer Center and Hospital
  - Mission Hills, California, United States, 91346-9600
    - Providence Holy Cross Cancer Center
  - Modesto, California, United States, 95355
    - Memorial Medical Center Cancer Services
  - Northridge, California, United States, 91325
    - Leavey Cancer Center at Northridge Hospital Medical Center
  - Oakland, California, United States, 94602
    - Highland General Hospital
  - Oakland, California, United States, 94609
    - CCOP - Bay Area Tumor Institute
  - Oakland, California, United States, 94609
    - Summit Medical Center
  - Palo Alto, California, United States, 94301
    - Palo Alto Medical Foundation
  - Pomona, California, United States, 91767
    - Pomona Valley Hospital Medical Center
  - Sacramento, California, United States, 95817
    - University of California Davis Cancer Center
  - Sacramento, California, United States, 95815
    - Radiological Associates of Sacramento Medical Group, Inc.
  - San Diego, California, United States, 92134
    - Naval Medical Center - San Diego
  - San Francisco, California, United States, 94118
    - California Pacific Medical Center - California Campus
  - San Pablo, California, United States, 94806
    - J.C. Robinson, M.D. Regional Cancer Center
  - Sana Rosa, California, United States, 95405
    - CCOP - Santa Rosa Memorial Hospital
  - Torrance, California, United States, 90509
    - Torrance Memorial Medical Center
  - Vallejo, California, United States, 94589
    - Sutter Solano Medical Center
- Colorado
  - Aurora, Colorado, United States, 80012
    - Aurora Presbyterian Hospital
  - Boulder, Colorado, United States, 80301
    - Boulder Community Hospital
  - Colorado Springs, Colorado, United States, 80909
    - Memorial Hospital Cancer Center
  - Colorado Springs, Colorado, United States, 80933
    - Penrose Cancer Center at Penrose Hospital
  - Denver, Colorado, United States, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, United States, 80220
    - Rose Medical Center
  - Denver, Colorado, United States, 80218
    - Presbyterian - St. Luke's Medical Center
  - Denver, Colorado, United States, 80218
    - St. Joseph Hospital
  - Denver, Colorado, United States, 80224-2522
    - CCOP - Colorado Cancer Research Program, Incorporated
  - Englewood, Colorado, United States, 80110
    - Swedish Medical Center
  - Fort Collins, Colorado, United States, 80524
    - Front Range Cancer Specialists
  - Grand Junction, Colorado, United States, 81502
    - St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
  - Lone Tree, Colorado, United States, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, United States, 80502
    - Hope Cancer Care Center at Longmont United Hospital
  - Pueblo, Colorado, United States, 81004
    - St. Mary-Corwin Regional Medical Center
  - Thorton, Colorado, United States, 80229
    - North Suburban Medical Center
- Connecticut
  - Middletown, Connecticut, United States, 06457
    - Middlesex Hospital Cancer Center
- Delaware
  - Lewes, Delaware, United States, 19958
    - Beebe Medical Center
  - Newark, Delaware, United States, 19718
    - CCOP - Christiana Care Health Services
  - Wilmington, Delaware, United States, 19805
    - St. Francis Hospital
- District of Columbia
  - Washington, District of Columbia, United States, 20007
    - Lombardi Cancer Center at Georgetown University Medical Center
- Florida
  - Fort Lauderdale, Florida, United States, 33308
    - Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
  - Fort Myers, Florida, United States, 33901
    - 21st Century Oncology - Fort Myers
  - Hollywood, Florida, United States, 33021
    - Memorial Cancer Institute at Memorial Regional Hospital
  - Jacksonville, Florida, United States, 32207
    - Baptist Cancer Institute - Jacksonville
  - Jacksonville, Florida, United States, 32224-9980
    - Mayo Clinic - Jacksonville
  - Jupiter, Florida, United States, 33458
    - Ella Milbank Foshay Cancer Center at Jupiter Medical Center
  - Miami, Florida, United States, 33136
    - University of Miami Sylvester Comprehensive Cancer Center
  - Miami, Florida, United States, 33176
    - Baptist-South Miami Regional Cancer Program
  - Miami Beach, Florida, United States, 33140
    - CCOP - Mount Sinai Medical Center
  - Panama City, Florida, United States, 32405
    - Gulf Coast Cancer Treatment Center
  - Tallahassee, Florida, United States, 32308
    - Tallahassee Memorial Hospital
  - Tampa, Florida, United States, 33612
    - H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
- Georgia
  - Altanta, Georgia, United States, 30322
    - Emory University Hospital - Atlanta
  - Gainesville, Georgia, United States, 30501
    - Northeast Georgia Medical Center
  - Valdosta, Georgia, United States, 31603
    - Pearlman Comprehensive Cancer Center at South Georgia Medical Center
- Idaho
  - Boise, Idaho, United States, 83706
    - Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
  - Boise, Idaho, United States, 83712
    - Mountain States Tumor Institute - Boise
- Illinois
  - Alton, Illinois, United States, 62002
    - Saint Anthony's Hospital at Saint Anthony's Health Center
  - Arlington Heights, Illinois, United States, 60005
    - Northwest Community Hospital
  - Aurora, Illinois, United States, 60507
    - Rush-Copley Cancer Care Center
  - Barrington, Illinois, United States, 60010
    - Good Shepherd Hospital
  - Bloomington, Illinois, United States, 61701
    - St. Joseph Medical Center
  - Canton, Illinois, United States, 61520
    - Graham Hospital
  - Carthage, Illinois, United States, 62321
    - Memorial Hospital
  - Chicago, Illinois, United States, 60611
    - Robert H. Lurie Comprehensive Cancer Center at Northwestern University
  - Chicago, Illinois, United States, 60657
    - Creticos Cancer Center at Advocate Illinois Masonic Medical Center
  - Downers Grove, Illinois, United States, 60515
    - Cancer Care Center at Advocate Good Samaritan Hospital
  - Effingham, Illinois, United States, 62401
    - St. Anthony's Memorial Hospital
  - Eureka, Illinois, United States, 61530
    - Eureka Hospital
  - Evanston, Illinois, United States, 60201
    - Evanston Northwestern Health Care - Evanston Hospital
  - Galesburg, Illinois, United States, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, United States, 61401
    - Galesburg Clinic
  - Galesburg, Illinois, United States, 61401
    - InterCommunity Cancer Center of Western Illinois
  - Havana, Illinois, United States, 62644
    - Mason District Hospital
  - Hinsdale, Illinois, United States, 60521
    - Hinsdale Hematology Oncology Associates
  - Hopedale, Illinois, United States, 61747
    - Hopedale Medical Complex
  - Joliet, Illinois, United States, 60435
    - Joliet Oncology Hematology Associates, Limited - West
  - Kewanee, Illinois, United States, 61443
    - Kewanee Hospital
  - Macomb, Illinois, United States, 61455
    - Mcdonough District Hospital
  - Naperville, Illinois, United States, 60566
    - Edward Hospital Cancer Center
  - Normal, Illinois, United States, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, United States, 61761
    - Community Cancer Center
  - Ottawa, Illinois, United States, 61350
    - Community Hospital of Ottawa
  - Ottawa, Illinois, United States, 61350
    - Oncology Hematology Associates of Central Illinois - Ottawa
  - Park Ridge, Illinois, United States, 60068
    - Lutheran General Cancer Care Center
  - Pekin, Illinois, United States, 61554
    - Cancer Treatment Center at Pekin Hospital
  - Peoria, Illinois, United States, 61614
    - Proctor Hospital
  - Peoria, Illinois, United States, 61603
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, United States, 61637
    - OSF St. Francis Medical Center
  - Peoria, Illinois, United States, 61615
    - CCOP - Illinois Oncology Research Association
  - Peoria, Illinois, United States, 61615
    - Oncology/Hematology Associates of Central Illinois, P.C.
  - Peru, Illinois, United States, 61354
    - Illinois Valley Community Hospital
  - Princeton, Illinois, United States, 61356
    - Perry Memorial Hospital
  - Rockford, Illinois, United States, 61104
    - Swedish American Hospital
  - Spring Valley, Illinois, United States, 61362
    - St. Margaret's Hospital
  - Spring Valley, Illinois, United States, 61362
    - Valley Cancer Center
  - Urbana, Illinois, United States, 61801
    - Carle Cancer Center at Carle Foundation Hospital
  - Urbana, Illinois, United States, 61801
    - CCOP - Carle Cancer Center
- Indiana
  - Beech Grove, Indiana, United States, 46107
    - St. Francis Hospital and Health Centers
  - Bloomington, Indiana, United States, 47403
    - Bloomington Hospital
  - Elkhart, Indiana, United States, 46515
    - Elkhart General Hospital
  - La Porte, Indiana, United States, 46350
    - Center for Cancer Therapy at LaPorte Hospital and Health Services
  - Michigan City, Indiana, United States, 46360
    - Saint Anthony Memorial Health Centers
  - Muncie, Indiana, United States, 47303
    - Cancer Center at Ball Memorial Hospital
  - Plymouth, Indiana, United States, 46544
    - Saint Joseph Regional Medical Center - Plymouth Campus
  - South Bend, Indiana, United States, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, United States, 46601
    - CCOP - Northern Indiana CR Consortium
  - Terre Haute, Indiana, United States, 47804
    - Union Hospital
- Iowa
  - Ames, Iowa, United States, 50010
    - McFarland Clinic, P.C.
  - Carroll, Iowa, United States, 51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids, Iowa, United States, 52402
    - St. Luke's Hospital
  - Cedar Rapids, Iowa, United States, 52403
    - Cedar Rapids Oncology Associates
  - Cedar Rapids, Iowa, United States, 52403
    - Mercy Cancer Center at Mercy Medical Center
  - Council Bluffs, Iowa, United States, 51503
    - Alegent Health Mercy Hospital
  - Davenport, Iowa, United States, 52804
    - Genesis Medical Center - West Campus
  - Davenport, Iowa, United States, 52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines, Iowa, United States, 50309
    - CCOP - Iowa Oncology Research Association
  - Des Moines, Iowa, United States, 50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines, Iowa, United States, 50309
    - Medical Oncology and Hematology Associates at John Stoddard Cancer Center
  - Des Moines, Iowa, United States, 50314
    - Medical Oncology and Hematology Associates at Mercy Cancer Center
  - Des Moines, Iowa, United States, 50314
    - Mercy Cancer Center at Mercy Medical Center - Des Moines
  - Des Moines, Iowa, United States, 50316
    - John Stoddard Cancer Center at Iowa Lutheran Hospital
  - Des Moines, Iowa, United States, 50307
    - Mercy Capitol Hospital
  - Dubuque, Iowa, United States, 52001
    - Wendt Regional Cancer Center at Finley Hospital
  - Iowa City, Iowa, United States, 52242
    - Holden Comprehensive Cancer Center at University of Iowa
  - Mason City, Iowa, United States, 50401
    - Mercy Cancer Center at Mercy Medical Center - North Iowa
  - Missouri Valley, Iowa, United States, 51555
    - Alegent Health Community Memorial Hospital
  - Onawa, Iowa, United States, 51040
    - Burgess Health Center
  - Sioux City, Iowa, United States, 51104
    - St. Luke's Regional Medical Center
  - Sioux City, Iowa, United States, 51104
    - Mercy Medical Center - Sioux City
  - Sioux City, Iowa, United States, 51101
    - Siouxland Hematology-Oncology Associates
  - West Des Moines, Iowa, United States, 50266
    - Medical Oncology and Hematology Associates - West Des Moines
- Kansas
  - Arkansas City, Kansas, United States, 67005
    - South Central Kansas Regional Medical Center
  - Chanute, Kansas, United States, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, United States, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, United States, 67042
    - Cancer Center of Kansas, P.A. - El Dorado
  - Kansas City, Kansas, United States, 66160
    - Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
  - Kingman, Kansas, United States, 67068
    - Cancer Center of Kansas - Kingman
  - Liberal, Kansas, United States, 67901
    - Southwest Medical Center
  - Newton, Kansas, United States, 67114
    - Cancer Center of Kansas - Newton
  - Ottawa, Kansas, United States, 66067
    - Cancer Center of Kansas - Ottawa
  - Parsons, Kansas, United States, 67357
    - Cancer Center of Kansas, P.A. - Parsons
  - Pratt, Kansas, United States, 67124
    - Pratt Cancer Center of Kansas
  - Salina, Kansas, United States, 67042
    - Cancer Center of Kansas - Salina
  - Wellington, Kansas, United States, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, United States, 67214
    - Wesley Medical Center
  - Wichita, Kansas, United States, 67214
    - CCOP - Wichita
  - Wichita, Kansas, United States, 67214
    - Via Christi Cancer Center at Via Christi Regional Medical Center
  - Wichita, Kansas, United States, 67203
    - Associates In Womens Health
  - Wichita, Kansas, United States, 67208
    - Cancer Center of Kansas, P.A.
  - Wichita, Kansas, United States, 67214
    - Cancer Center of Kansas, P.A. - Wichita
  - Winfield, Kansas, United States, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Bowling Green, Kentucky, United States, 42101
    - Cancer Treatment Center at the Medical Center - Bowling Green
  - Lexington, Kentucky, United States, 40536
    - Markey Cancer Center at University of Kentucky Chandler Medical Center
  - Lexington, Kentucky, United States, 40503
    - Central Baptist Hospital
  - Madisonville, Kentucky, United States, 42431
    - Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County
- Louisiana
  - Monroe, Louisiana, United States, 71210
    - Louisiana State University Health Sciences Center - Monroe
  - New Orleans, Louisiana, United States, 70112
    - Tulane Cancer Center
  - Shreveport, Louisiana, United States, 71101
    - Veterans Affairs Medical Center - Shreveport
  - Shreveport, Louisiana, United States, 71130
    - Feist-Weiller Cancer Center at Louisiana State University Health Sciences
- Maine
  - Bangor, Maine, United States, 04401
    - CancerCare of Maine at Eastern Maine Medial Center
  - Lewiston, Maine, United States, 04240
    - Central Maine Medical Center
  - Waterville, Maine, United States, 04901
    - Maine General Medical Center - Waterville
- Maryland
  - Annapolis, Maryland, United States, 21401
    - DeCesaris Cancer Institute at Anne Arundel Medical Center
  - Baltimore, Maryland, United States, 21287-8936
    - Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  - Elkton MD, Maryland, United States, 21921
    - Union Hospital Cancer Center at Union Hospital
- Massachusetts
  - Boston, Massachusetts, United States, 02115
    - Brigham and Women's Hospital
  - Boston, Massachusetts, United States, 02115
    - Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
  - Boston, Massachusetts, United States, 02114
    - Massachusetts General Hospital Cancer Center
  - Boston, Massachusetts, United States, 02118
    - Cancer Research Center at Boston Medical Center
  - Concord, Massachusetts, United States, 01742
    - Bethke Cancer Center at Emerson Hospital
  - Fall River, Massachusetts, United States, 02721
    - Hudner Oncology Center at Saint Anne's Hospital
  - Hyannis, Massachusetts, United States, 02601
    - Cape Cod Hospital
  - Newton, Massachusetts, United States, 02162
    - Newton - Wellesley Hospital
  - Quincy, Massachusetts, United States, 02169
    - South Suburban Oncology Center
- Michigan
  - Adrian, Michigan, United States, 49221
    - Hickman Cancer Center at Bixby Medical Center
  - Ann Arbor, Michigan, United States, 48109
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, United States, 48106-0995
    - St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
  - Ann Arbor, Michigan, United States, 48100
    - CCOP - Michigan Cancer Research Consortium
  - Battle Creek, Michigan, United States, 49017
    - Battle Creek Health System
  - Big Rapids, Michigan, United States, 49307
    - Mecosta County General Hospital
  - Detroit, Michigan, United States, 48202
    - Josephine Ford Cancer Center at Henry Ford Health System
  - Flint, Michigan, United States, 48502
    - Hurley Medical Center
  - Flint, Michigan, United States, 48532
    - Genesys Hurley Cancer Institute
  - Flint, Michigan, United States, 48532
    - Great Lakes Cancer Institute at McLaren Regional Medical Center
  - Grand Rapids, Michigan, United States, 49503
    - CCOP - Grand Rapids
  - Grand Rapids, Michigan, United States, 49503
    - Lacks Cancer Center at Saint Mary's Mercy Medical Center
  - Grand Rapids, Michigan, United States, 49503
    - Spectrum Health Cancer Care - Butterworth Campus
  - Grand Rapids, Michigan, United States, 49506
    - Metropolitan Hospital
  - Grand Rapids, Michigan, United States, 49506
    - Spectrum Health Hospital - Blodgett Campus
  - Holland, Michigan, United States, 49423
    - Holland Community Hospital
  - Kalamazoo, Michigan, United States, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, United States, 49007
    - Bronson Methodist Hospital
  - Kalamazooaa, Michigan, United States, 49001
    - Borgess Medical Center
  - Marquette, Michigan, United States, 49855
    - Upper Michigan Cancer Center at Marquette General Hospital
  - Muskegon, Michigan, United States, 49443
    - Hackley Hospital
  - Petoskey, Michigan, United States, 49770
    - Northern Michigan Hospital
  - Port Huron, Michigan, United States, 48060
    - Mercy Hospital
  - Saginaw, Michigan, United States, 48601
    - Seton Cancer Institute - Saginaw
  - Saint Joseph, Michigan, United States, 49085
    - Oncology Care Associates, P.L.L.C.
  - Southfield, Michigan, United States, 48075
    - Providence Cancer Institute at Providence Hospital - Southfield Campus
  - Traverse City, Michigan, United States, 49684
    - Munson Medical Center
  - Warren, Michigan, United States, 48903
    - St. John Macomb Hospital
- Minnesota
  - Bemidji, Minnesota, United States, 56601
    - MeritCare Clinic - Bemidji
  - Brainerd, Minnesota, United States, 56401
    - Brainerd Medical Center
  - Burnsville, Minnesota, United States, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, United States, 55433
    - Mercy Hospital
  - Duluth, Minnesota, United States, 55805
    - CCOP - Duluth
  - Duluth, Minnesota, United States, 55805
    - St. Mary's - Duluth Clinic Cancer Center
  - Duluth, Minnesota, United States, 55805
    - Miller-Dwan Medical Center
  - Duluth, Minnesota, United States, 55805
    - Cancer Care Center at St. Luke's Hospital
  - Edina, Minnesota, United States, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, United States, 55432
    - Mercy and Unity Cancer Center at Mercy and Unity Hospitals
  - Hutchinson, Minnesota, United States, 55350
    - Hutchinson Area Health Care
  - Litchfield, Minnesota, United States, 55355
    - Meeker County Memorial Hospital
  - Maplewood, Minnesota, United States, 55109
    - St. John's Hospital
  - Minneapolis, Minnesota, United States, 55415
    - Hennepin County Medical Center - Minneapolis
  - Minneapolis, Minnesota, United States, 55407
    - Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, United States, 55455
    - Fairview University Medical Center - University Campus
  - Montevideo, Minnesota, United States, 56265
    - Chippewa County - Montevideo Hospital
  - Robbinsdale, Minnesota, United States, 55422
    - Hubert H. Humphrey Cancer Center at North Memorial Medical Center
  - Rochester, Minnesota, United States, 55905
    - Mayo Clinic Cancer Center
  - Saint Louis Park, Minnesota, United States, 55416
    - CCOP - Metro-Minnesota
  - Saint Paul, Minnesota, United States, 55101
    - Cancer Care Center at Regions Hospital
  - Shakopee, Minnesota, United States, 55379
    - Saint Francis Cancer Center
  - St Paul, Minnesota, United States, 55102
    - St. Joseph's Hospital
  - St. Cloud, Minnesota, United States, 56303
    - CentraCare Clinic - River Campus
  - St. Cloud, Minnesota, United States, 56303
    - Adult and Pediatric Urology, P.L.L.P.
  - St. Louis Park, Minnesota, United States, 55416
    - Park Nicollet Clinic
  - St. Paul, Minnesota, United States, 55102
    - United Hospital
  - Waconia, Minnesota, United States, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, United States, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, United States, 55125
    - Woodwinds Hospital
- Mississippi
  - Jackson, Mississippi, United States, 39216
    - Veterans Affairs Medical Center - Jackson
  - Jackson, Mississippi, United States, 39216
    - University of Mississippi Medical Center
  - Pascagoula, Mississippi, United States, 39581
    - Regional Cancer Center at Singing River Hospital
- Missouri
  - Cape Girardeau, Missouri, United States, 63701
    - St. Francis Medical Center
  - Chesterfield, Missouri, United States, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, United States, 65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Columbia, Missouri, United States, 65201
    - Missouri Cancer Associates
  - Gape Girardeau, Missouri, United States, 63701
    - Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
  - Kansas City, Missouri, United States, 64131
    - CCOP - Kansas City
  - Springfield, Missouri, United States, 65804
    - St. John's Regional Health Center
  - Springfield, Missouri, United States, 65807
    - Hulston Cancer Center at Cox Medical Center South
  - St Louis, Missouri, United States, 63110
    - Siteman Cancer Center at Barnes-Jewish Hospital
  - St. Louis, Missouri, United States, 63131
    - Missouri Baptist Cancer Center
  - St. Louis, Missouri, United States, 63141
    - CCOP - St. Louis-Cape Girardeau
  - St. Louis, Missouri, United States, 63141
    - David C. Pratt Cancer Center at St. John's Mercy
  - St. Louis, Missouri, United States, 63141
    - Center for Cancer Care and Research
- Montana
  - Billings, Montana, United States, 59101
    - CCOP - Montana Cancer Consortium
  - Great Falls, Montana, United States, 59405
    - Great Falls Clinic
  - Great Falls, Montana, United States, 59405
    - Sletten Regional Cancer Institute
- Nebraska
  - Fremont, Nebraska, United States, 68025
    - Fremont Area Medical Center
  - Kearney, Nebraska, United States, 68847
    - Cancer Center at the Good Samaritan Health Systems
  - Lincoln, Nebraska, United States, 68502
    - Bryan LGH Medical Center West
  - Lincoln, Nebraska, United States, 68510
    - Cancer Resource Center - Lincoln
  - Lincoln, Nebraska, United States, 68510
    - St. Elizabeth Regional Medical Center
  - Omaha, Nebraska, United States, 68106
    - CCOP - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, United States, 68114
    - Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
  - Omaha, Nebraska, United States, 68124
    - Bergan Mercy Medical Center
  - Omaha, Nebraska, United States, 68122
    - Alegent Health - Immanuel Medical Center
  - Omaha, Nebraska, United States, 68131
    - Cancer Center at Creighton University Medical Center
  - Papillion, Nebraska, United States, 68046
    - Midlands Cancer Center at Midlands Community Hospital
- Nevada
  - Las Vegas, Nevada, United States, 89106
    - CCOP - Southern Nevada Cancer Research Foundation
  - Las Vegas, Nevada, United States, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, United States, 89102
    - University Medical Center of Southern Nevada
  - Reno, Nevada, United States, 89502
    - Washoe Cancer Services at Washoe Medical Center - Reno
- New Hampshire
  - Lebanon, New Hampshire, United States, 03756
    - Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
- New Jersey
  - Camden, New Jersey, United States, 08103
    - Cancer Institute of New Jersey at the Cooper University Hospital
  - Hackensack, New Jersey, United States, 07601
    - CCOP - Northern New Jersey
  - Long Branch, New Jersey, United States, 07740
    - Monmouth Medical Center
  - Millville, New Jersey, United States, 08332
    - South Jersey Healthcare Regional Cancer Center
  - Montclair, New Jersey, United States, 07042
    - Cancer Center at the Mountainside Hospital
  - Mount Holly, New Jersey, United States, 08060
    - Fox Chase Virtua Health Cancer Program - Marlton
  - Newark, New Jersey, United States, 07112
    - Newark Beth Israel Medical Center
  - Pomona, New Jersey, United States, 08240
    - Atlantic City Medical Center - Mainland Division
  - Red Bank, New Jersey, United States, 07701
    - Booker Cancer Center at Riverview Medical Center
  - Toms River, New Jersey, United States, 08755
    - Community Medical Center
  - Trenton, New Jersey, United States, 08611
    - Fox Chase Cancer Center at St. Francis Medical Center
  - Trenton, New Jersey, United States, 08618
    - Capital Health System Regional Cancer Center
- New Mexico
  - Albuquerque, New Mexico, United States, 87106
    - University of New Mexico Cancer Research and Treatment Center
  - Albuquerque, New Mexico, United States, 87108
    - Lovelace Medical Center at Lovelace Sandia Health System
  - Albuquerque, New Mexico, United States, 87106
    - Hematology-Oncology Associates, PC
- New York
  - Brooklyn, New York, United States, 11203
    - SUNY Downstate Medical Center
  - Brooklyn, New York, United States, 11215
    - New York Methodist Hospital
  - Clifton Springs, New York, United States, 14432
    - Finger Lakes Hematology and Oncology
  - Cooperstown, New York, United States, 13326
    - Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital
  - Harris, New York, United States, 12742
    - Catskill Regional Medical Center
  - Manhasset, New York, United States, 11030
    - CCOP - North Shore University Hospital
  - New York, New York, United States, 10021
    - New York Weill Cornell Cancer Center at Cornell University
  - Rochester, New York, United States, 14642
    - James P. Wilmot Cancer Center at University of Rochester Medical Center
  - Rochester, New York, United States, 14620
    - Highland Hospital of Rochester
  - Syracuse, New York, United States, 13210
    - Veterans Affairs Medical Center - Syracuse
  - Syracuse, New York, United States, 13057
    - CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
  - Syracuse, New York, United States, 13215
    - Community General Hospital of Greater Syracuse
  - Syracuse, New York, United States, 13210
    - Crouse Hospital
- North Carolina
  - Asheboro, North Carolina, United States, 27203
    - Randolph Hospital
  - Charlotte, North Carolina, United States, 28233
    - Presbyterian Cancer Center at Presbyterian Hospital
  - Charlotte, North Carolina, United States, 28203
    - Blumenthal Cancer Center at Carolinas Medical Center
  - Eden, North Carolina, United States, 27288
    - John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital
  - Goldsboro, North Carolina, United States, 27534
    - Wayne Radiation Oncology
  - Goldsboro, North Carolina, United States, 27534
    - Wayne Memorial Hospital, Incorporated
  - Greensboro, North Carolina, United States, 27401
    - Moses Cone Regional Cancer Center at Wesley Long Community Hospital
  - Kinston, North Carolina, United States, 28501
    - Lenoir Memorial Cancer Center
  - Reidsville, North Carolina, United States, 27320
    - Annie Penn Cancer Center
  - Wilmington, North Carolina, United States, 28401
    - Zimmer Cancer Center at New Hanover Regional Medical Center
  - Wilson, North Carolina, United States, 27893
    - Wilson Medical Center
  - Winston-Salem, North Carolina, United States, 27103
    - Forsyth Regional Cancer Center at Forsyth Medical Center
- North Dakota
  - Bismarck, North Dakota, United States, 58501
    - Medcenter One Health System
  - Bismarck, North Dakota, United States, 58501
    - Mid Dakota Clinic, P.C.
  - Bismarck, North Dakota, United States, 58501
    - Bismarck Cancer Center
  - Bismarck, North Dakota, United States, 58501
    - St. Alexius Medical Center
  - Fargo, North Dakota, United States, 58122
    - CCOP - MeritCare Hospital
  - Fargo, North Dakota, United States, 58122
    - MeritCare Medical Group
  - Grand Forks, North Dakota, United States, 58201
    - Altru Cancer Center at Altru Hospital
  - Minot, North Dakota, United States, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, United States, 44307
    - McDowell Cancer Center at Akron General Medical Center
  - Akron, Ohio, United States, 44304
    - Akron City Hospital at Summa Health System
  - Canton, Ohio, United States, 44708
    - University Hospitals Ireland Cancer Center at Mercy Medical Center
  - Chillicothe, Ohio, United States, 54601
    - Adena Regional Medical Center
  - Cleveland, Ohio, United States, 44195
    - Cleveland Clinic Taussig Cancer Center
  - Cleveland, Ohio, United States, 44109
    - MetroHealth's Cancer Care Center at MetroHealth Medical Center
  - Cleveland, Ohio, United States, 44106
    - Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University
  - Cleveland, Ohio, United States, 44112
    - Huron Hospital Cancer Care Center
  - Cleveland, Ohio, United States, 44119
    - Euclid Hospital
  - Columbus, Ohio, United States, 43215
    - CCOP - Columbus
  - Columbus, Ohio, United States, 43228
    - Doctors Hospital at Ohio Health
  - Columbus, Ohio, United States, 43214
    - Riverside Methodist Hospital Cancer Care
  - Columbus, Ohio, United States, 43215
    - Grant Riverside Cancer Services
  - Columbus, Ohio, United States, 43222
    - Mount Carmel West Hospital
  - Columbus, Ohio, United States, 43210
    - Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
  - Dayton, Ohio, United States, 45428
    - Veterans Affairs Medical Center - Dayton
  - Dayton, Ohio, United States, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, United States, 45405
    - Grandview Hospital
  - Dayton, Ohio, United States, 45406
    - Good Samaritan Hospital
  - Dayton, Ohio, United States, 45415
    - Samaritan North Cancer Care Center
  - Dayton, Ohio, United States, 45429
    - CCOP - Dayton
  - Delaware, Ohio, United States, 43015
    - Grady Memorial Hospital
  - Kettering, Ohio, United States, 45429
    - Charles F. Kettering Memorial Hospital
  - Lancaster, Ohio, United States, 43130
    - Fairfield Medical Center
  - Lima, Ohio, United States, 45804
    - Lima Memorial Hospital
  - Lima, Ohio, United States, 45801
    - St. Rita's Medical Center
  - Marietta, Ohio, United States, 45750
    - Strecker Cancer Center at Marietta Memorial Hospital
  - Maumee, Ohio, United States, 43537
    - St. Luke's Hospital
  - Mayfield Heights, Ohio, United States, 44124
    - Hillcrest Cancer Center at Hillcrest Hospital
  - Middletown, Ohio, United States, 45044
    - Middletown Regional Hospital
  - Newark, Ohio, United States, 43055
    - Licking Memorial Cancer Care Program at Licking Memorial Hospital
  - Oregon, Ohio, United States, 43616
    - St. Charles Mercy Hospital
  - Salem, Ohio, United States, 44460
    - Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford
  - Sandusky, Ohio, United States, 44870
    - Firelands Regional Medical Center
  - Springfield, Ohio, United States, 45505
    - Community Hospital of Springfield and Clark County
  - Springfield, Ohio, United States, 45504
    - Mercy Medical Center Oncology Unit
  - Sylvania, Ohio, United States, 43560
    - Promedica Cancer Center at Flower Hospital
  - Tiffin, Ohio, United States, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, United States, 43608
    - St. Vincent Mercy Medical Center
  - Toledo, Ohio, United States, 43606
    - Toledo Hospital
  - Toledo, Ohio, United States, 43623
    - CCOP - Toledo Community Hospital
  - Toledo, Ohio, United States, 43614
    - Medical College of Ohio Cancer Institute
  - Toledo, Ohio, United States, 43623
    - Toledo Clinic, Incorporated
  - Troy, Ohio, United States, 45373
    - UVMC Cancer Care Center at Upper Valley Medical Center
  - Warrensville Heights, Ohio, United States, 44122
    - South Pointe Hospital Cancer Care Center
  - Westerville, Ohio, United States, 43081
    - Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital
  - Wooster, Ohio, United States, 44691
    - Cancer Treatment Center
  - Xenia, Ohio, United States, 45385
    - Ruth G. McMillan Cancer Center at Greene Memorial Hospital
  - Zanesville, Ohio, United States, 43701
    - Genesis - Good Samaritan Hospital
- Oklahoma
  - Tulsa, Oklahoma, United States, 74136
    - Natalie Warren Bryant Cancer Center at St. Francis Hospital
  - Tulsa, Oklahoma, United States, 74104
    - LaFortune Cancer Center at St. John Health System
- Oregon
  - Glesham, Oregon, United States, 97030
    - Legacy Mount Hood Medical Center
  - Milwaukie, Oregon, United States, 97222
    - Providence Milwaukie Hospital
  - Portland, Oregon, United States, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, United States, 97225
    - Providence St. Vincent Medical Center
  - Portland, Oregon, United States, 97210
    - Comprehensive Cancer Center at Legacy Good Samaritan Hospital & Medical Center
  - Portland, Oregon, United States, 97213
    - Providence Cancer Center at Providence Portland Medical Center
  - Portland, Oregon, United States, 97227
    - Institute of Oncology at Vilnius University
  - Portland, Oregon, United States, 97232
    - Kaiser Permanente Health Care - Portland
  - Portland, Oregon, United States, 97239
    - Cancer Institute at Oregon Health and Science University
  - Salem, Oregon, United States, 97309
    - Salem Hospital Regional Cancer Center
  - Tualatin, Oregon, United States, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Allentown, Pennsylvania, United States, 18105
    - John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
  - Bethlehem, Pennsylvania, United States, 18015
    - St. Luke's Hospital Cancer Center
  - Bryn Mawr, Pennsylvania, United States, 19010
    - Bryn Mawr Hospital
  - Danville, Pennsylvania, United States, 17822-2001
    - Geisinger Medical Center
  - Drexel Hill, Pennsylvania, United States, 19026
    - Delaware County Regional Cancer Center at Delaware County Memorial Hospital
  - Hershey, Pennsylvania, United States, 17033-0850
    - Penn State Cancer Institute at Milton S. Hershey Medical Center
  - Langhorne, Pennsylvania, United States, 19047
    - St. Mary Regional Cancer Center
  - Lewistown, Pennsylvania, United States, 17044
    - Lewistown Hospital
  - Paoli, Pennsylvania, United States, 19301
    - Cancer Center at Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, United States, 19111-2497
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, United States, 19141
    - Albert Einstein Cancer Center
  - Philadelphia, Pennsylvania, United States, 19107
    - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
  - Philadelphia, Pennsylvania, United States, 19107
    - Joan Karnell Cancer Center at Pennsylvania Hospital
  - Pittsburgh, Pennsylvania, United States, 15212
    - Allegheny Cancer Center at Allegheny General Hospital
  - Pittsburgh, Pennsylvania, United States, 15219
    - Mercy Hospital of Pittsburgh
  - Pittsburgh, Pennsylvania, United States, 15224-1791
    - Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
  - Pottstown, Pennsylvania, United States, 19464
    - Pottstown Memorial Regional Cancer Center
  - Reading, Pennsylvania, United States, 19604
    - St. Joseph Medical Center
  - Sayre, Pennsylvania, United States, 18840
    - Guthrie Medical Center - Sayre
  - Scranton, Pennsylvania, United States, 18501
    - Mercy Hospital Cancer Center - Scranton
  - State College, Pennsylvania, United States, 16801
    - Geisinger Medical Group
  - State College, Pennsylvania, United States, 16803
    - Mount Nittany Medical Center
  - West Reading, Pennsylvania, United States, 19612
    - Reading Hospital and Medical Center
  - Wilkes-Barre, Pennsylvania, United States, 18711
    - Geisinger Wyoming Valley Medical Center
  - Wynnewood, Pennsylvania, United States, 19096
    - CCOP - MainLine Health
  - Wynnewood, Pennsylvania, United States, 19096
    - Lankenau Cancer Center at Lankenau Hospital
- South Carolina
  - Greenville, South Carolina, United States, 29615
    - CCOP - Greenville
  - Greenville, South Carolina, United States, 29601
    - Bon Secours St. Francis Health System
  - Greenville, South Carolina, United States, 29605
    - Greenville Hospital System Cancer Center
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, United States, 57105
    - Medical X-Ray Center
  - Sioux Falls, South Dakota, United States, 57104
    - Sioux Valley Hospital and University of South Dakota Medical Center
  - Sioux Falls, South Dakota, United States, 57105
    - Avera McKennan Hospital and University Health Center
- Tennessee
  - Memphis, Tennessee, United States, 38146
    - Baptist Centers for Cancer Care
- Texas
  - Amarillo, Texas, United States, 79106
    - Harrington Cancer Center
  - Bryan, Texas, United States, 77802
    - St. Joseph Regional Cancer Center
  - Fort Sam Houston, Texas, United States, 78234
    - Brooke Army Medical Center
  - Houston, Texas, United States, 77030
    - M.D. Anderson Cancer Center at University of Texas
  - Lackland AFB, Texas, United States, 78236
    - Wilford Hall Medical Center
  - Lubbock, Texas, United States, 79410
    - Joe Arrington Cancer Research and Treatment Center
  - San Antonio, Texas, United States, 78229
    - Cancer Therapy and Research Center
  - San Antonio, Texas, United States, 78209
    - Veterans Affairs Medical Center - San Antonio (Murphy)
  - San Antonio, Texas, United States, 78229
    - University Hospital - San Antonio
  - San Antonio, Texas, United States, 78284
    - University of Texas Health Science Center at San Antonio
- Utah
  - Murray, Utah, United States, 84107
    - Cottonwood Hospital Medical Center
  - Ogden, Utah, United States, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, United States, 84603
    - Utah Valley Regional Medical Center - Provo
  - Salt Lake City, Utah, United States, 84143
    - LDS Hospital
  - Salt Lake City, Utah, United States, 84112
    - Huntsman Cancer Institute at University of Utah
  - Salt Lake City, Utah, United States, 84106
    - Utah Cancer Specialists at UCS Cancer Center
  - St. George, Utah, United States, 84770
    - Dixie Regional Medical Center
- Vermont
  - Berlin, Vermont, United States, 05602
    - Mountainview Medical
  - Burlington, Vermont, United States, 05401
    - Fletcher Allen Health Care - University Health Center Campus
- Virginia
  - Danville, Virginia, United States, 24541
    - Danville Regional Medical Center
  - Hampton, Virginia, United States, 23666
    - Virginia Oncology Associates - Hampton
  - Richmond, Virginia, United States, 23226
    - Bon Secours Cancer Care at St. Mary's Hospital
- Washington
  - Bellingham, Washington, United States, 98225
    - St. Joseph Hospital Community Cancer Center
  - Bremerton, Washington, United States, 98310
    - Olympic Hematology and Oncology
  - Everett, Washington, United States, 98201
    - Providence Cancer Institute at Providence Everett Medical Center - Pacific Campus
  - Mt. Vernon, Washington, United States, 98273
    - Cancer Care Center at Skagit Valley Hospital
  - Seattle, Washington, United States, 98104
    - Harborview Medical Center
  - Seattle, Washington, United States, 98101
    - CCOP - Virginia Mason Research Center
  - Seattle, Washington, United States, 98104
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, United States, 98195
    - University Cancer Center at University of Washington Medical Center
  - Seattle, Washington, United States, 98104
    - Group Health Central Hospital
  - Seattle, Washington, United States, 98114
    - Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
  - Spokane, Washington, United States, 99202
    - Cancer Care Northwest - Spokane South
  - Tacoma, Washington, United States, 98431
    - Madigan Army Medical Center
  - Vancouver, Washington, United States, 98668
    - Cancer Center at Southwest Washington Medical Center
  - Wenatchee, Washington, United States, 98801
    - Central Washington Hospital
  - Wenatchee, Washington, United States, 98801
    - Wenatchee Valley Clinic
- West Virginia
  - Morgantown, West Virginia, United States, 26506
    - Mary Babb Randolph Cancer Center at West Virginia University Hospitals
  - Parkersburg, West Virginia, United States, 26101
    - Camden-Clark Memorial Hospital
- Wisconsin
  - Eau Claire, Wisconsin, United States, 54702
    - Luther Mildelfort Hospital
  - Eau Claire, Wisconsin, United States, 54702
    - Midelfort Clinic - Luther
  - Fond Du Lac, Wisconsin, United States, 54935
    - Central Wisconsin Cancer Program at Agnesian Health Care
  - Green Bay, Wisconsin, United States, 54303
    - Green Bay Oncology, Limited at St. Mary's Hospital
  - Green Bay, Wisconsin, United States, 54301-3526
    - Green Bay Oncology, Limited at St. Vincent Hospital
  - Green Bay, Wisconsin, United States, 54301
    - St. Vincent Hospital
  - Green Bay, Wisconsin, United States, 54303
    - St. Mary's Hospital Medical Center
  - La Crosse, Wisconsin, United States, 54601
    - Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
  - Madison, Wisconsin, United States, 53792
    - University of Wisconsin Comprehensive Cancer Center
  - Marinette, Wisconsin, United States, 54143
    - Bay Area Cancer Care Center at Bay Area Medical Center
  - Marshfield, Wisconsin, United States, 54449
    - Marshfield Clinic - Marshfield Center
  - Menomonee Falls, Wisconsin, United States, 53051
    - Community Memorial Hospital
  - Milwaukee, Wisconsin, United States, 53295
    - Veterans Affairs Medical Center - Milwaukee (Zablocki)
  - Milwaukee, Wisconsin, United States, 53226
    - Medical College of Wisconsin Cancer Center
  - Milwaukee, Wisconsin, United States, 53215
    - Vince Lombardi Cancer Clinic at St. Luke's Medical Center
  - Racine, Wisconsin, United States, 53405
    - All Saints Cancer Center at All Saints Healthcare
  - West Allis, Wisconsin, United States, 53227
    - West Allis Memorial Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 120 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Description

DISEASE CHARACTERISTICS:

Histologically confirmed primary squamous, basaloid, or cloacogenic carcinoma of the anal canal, other than carcinoma in situ
- T2-4, Any N, M0 (stage II or III)
No local or regional recurrence after local excision or abdominal peritoneal resection

PATIENT CHARACTERISTICS:

Age:

18 and over

Performance status:

Karnofsky 60-100%

Life expectancy:

Not specified

Hematopoietic:

WBC at least 4,000/mm^3
Absolute neutrophil count at least 1,800/mm^3
Platelet count at least 100,000/mm^3
Hemoglobin at least 10 g/dL

Hepatic:

Bilirubin less than 1.4 mg/dL

Renal:

Creatinine no greater than 1.5 mg/dL OR
Creatinine clearance at least 80 mL/min

Cardiovascular:

No uncompensated heart disease
No uncontrolled high blood pressure

Other:

No AIDS
No active systemic infection
No uncontrolled diabetes
No other prior malignancy within the past 5 years except nonmelanoma skin cancer
No mental condition that would preclude study participation
Not pregnant or nursing
Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

Prior epoetin alfa allowed in lieu of blood transfusions

Chemotherapy:

At least 5 years since prior chemotherapy

Endocrine therapy:

Not specified

Radiotherapy:

At least 5 years since prior radiotherapy

Surgery:

No prior surgery of anal canal except for biopsy of study site

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: TREATMENT
Allocation: RANDOMIZED

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Radiation Therapy Oncology Group

Collaborators

National Cancer Institute (NCI)

Eastern Cooperative Oncology Group

Southwest Oncology Group

Cancer and Leukemia Group B

North Central Cancer Treatment Group

Investigators

Study Chair: Joel E. Tepper, MD, UNC Lineberger Comprehensive Cancer Center

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Ben-Josef E, Moughan J, Ajani JA, Flam M, Gunderson L, Pollock J, Myerson R, Anne R, Rosenthal SA, Willett C. Impact of overall treatment time on survival and local control in patients with anal cancer: a pooled data analysis of Radiation Therapy Oncology Group trials 87-04 and 98-11. J Clin Oncol. 2010 Dec 1;28(34):5061-6. doi: 10.1200/JCO.2010.29.1351. Epub 2010 Oct 18.
Glynne-Jones R, Mawdsley S. Anal cancer: is neoadjuvant cisplatin chemotherapy or chemoradiotherapy friend or foe? Nat Clin Pract Oncol. 2008 Dec;5(12):692-3. doi: 10.1038/ncponc1258. Epub 2008 Oct 14.
Gunderson LL, Winter KA, Ajani JA, et al.: Long-term update of U.S. GI intergroup RTOG 98-11 phase III trial for anal carcinoma: disease-free and overall survival with RT+5FU-mitomycin versus RT+5FU-cisplatin. [Abstract] J Clin Oncol 29 (Suppl 15): A-4005, 2011.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG. Prognostic factors derived from a prospective database dictate clinical biology of anal cancer: the intergroup trial (RTOG 98-11). Cancer. 2010 Sep 1;116(17):4007-13. doi: 10.1002/cncr.25188.
Gunderson LL, Moughan J, Ajani JA, et al.: Anal carcinoma: Impact of TN category of disease on survival, disease relapse, and colostomy failure in U.S. GI Intergroup RTOG 98-11 phase III trial. [Abstract] American Society of Clinical Oncology 2010 Gastrointestinal Cancers Symposium, 22-24 January 2010, Orlando, Florida. A-285, 2010.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG. US intergroup anal carcinoma trial: tumor diameter predicts for colostomy. J Clin Oncol. 2009 Mar 1;27(7):1116-21. doi: 10.1200/JCO.2008.19.6857. Epub 2009 Jan 12.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA. 2008 Apr 23;299(16):1914-21. doi: 10.1001/jama.299.16.1914.
Ajani JA, Winter KA, Gunderson LL, et al.: Intergroup RTOG 98-11: a phase III randomized study of 5-fluorouracil (5-FU), mitomycin, and radiotherapy versus 5-fluorouracil, cisplatin and radiotherapy in carcinoma of the anal canal. [Abstract] J Clin Oncol 24 (Suppl 18): A-4009, 2006.
Gunderson LL, Winter KA, Ajani JA, et al.: Intergroup RTOG 9811 phase III comparison of chemoradiation with 5-FU and mitomycin vs 5-FU and cisplatin for anal canal carcinoma: impact on disease-free, overall and colostomy-free survival. [Abstract] Int J Radiat Oncol Biol Phys 66 (3 Suppl 1): A-43, S24, 2006.
Gunderson LL, Winter KA, Ajani JA, Pedersen JE, Moughan J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG. Long-term update of US GI intergroup RTOG 98-11 phase III trial for anal carcinoma: survival, relapse, and colostomy failure with concurrent chemoradiation involving fluorouracil/mitomycin versus fluorouracil/cisplatin. J Clin Oncol. 2012 Dec 10;30(35):4344-51. doi: 10.1200/JCO.2012.43.8085. Epub 2012 Nov 13.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 1998

Primary Completion (ACTUAL)

October 1, 2005

Study Completion (ACTUAL)

December 1, 2016

Study Registration Dates

First Submitted

November 1, 1999

First Submitted That Met QC Criteria

January 26, 2003

First Posted (ESTIMATE)

January 27, 2003

Study Record Updates

Last Update Posted (ESTIMATE)

January 4, 2017

Last Update Submitted That Met QC Criteria

December 30, 2016

Last Verified

December 1, 2016

More Information

Terms related to this study

Keywords

Other Study ID Numbers

RTOG-9811
CDR0000066667
CALGB-89808
ECOG-R9811
NCCTG-R9811
SWOG-R9811
GUMC-00125

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Recruiting

Phase 1b/II Trial of Pembrolizumab Plus IMRT in Stage III/IV Carcinoma of Anus (CORINTH)

Anal Cancer Stage III A | Anal Cancer Stage III B

United Kingdom, Norway
Goethe University

Active, not recruiting

Radiochemotherapy +/- Durvalumab for Locally-advanced Anal Carcinoma. A Multicenter, Randomized, Phase II Trial of the German Anal Cancer Study Group (RADIANCE)

Anal Cancer | Anal Carcinoma | Anal Cancer Stage III | Anal Cancer Stage II

Germany, Switzerland, Austria
Sixth Affiliated Hospital, Sun Yat-sen University

Recruiting

Chemoradiotherapy Combined With or Without PD-1 Blockade in Anal Canal Squamous Carcinoma Patients

Anal Canal Cancer | Anal Squamous Cell Carcinoma | Anal Cancer | Anal Canal Cancer Stage III

China

Clinical Trials on fluorouracil

The Netherlands Cancer Institute

Completed

Safety, Feasibility and Cost-effectiveness of Genotype-directed Individualized Dosing of Fluoropyrimidines

Neoplasms

Netherlands
Sun Yat-sen University
Zhejiang Cancer Hospital; Fudan University; Peking University Cancer Hospital... and other collaborators

Unknown

Adjuvant Chemotherapy in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma

China
CStone Pharmaceuticals

Active, not recruiting

A Study of CS1001 in Subjects With Esophageal Squamous Cell Carcinoma

Unresectable Locally Advanced, Recurrent or Metastatic Esophageal Squamous Cell Carcinoma

China
Sun Yat-sen University

Unknown

Neoadjuvant FOLFOX6 Chemotherapy With or Without Radiation in Rectal Cancer (FOWARC)

Rectal Cancer

China
The Netherlands Cancer Institute

Completed

Pharmacogenomic and Pharmacokinetic Safety and Cost-saving Analysis in Patients Treated With Fluoropyrimidines

Neoplasms

Netherlands
Actavis Inc.

Completed

Multicenter, Double-blind, Placebo Controlled Comparing Test Fluorouracil Cream to Carac Cream in Actinic Keratosis

Actinic Keratosis

United States
Hui ting Xu，MD
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Clinical Study of Apatinib and 5-Fu Combination Regimen to Treat Advanced Colorectal Cancer Patients

Metastatic Colorectal Cancer

China
Kansai Hepatobiliary Oncology Group

Unknown

P2 Study of Postoperative Interferon/Fluorouracil vs Cisplatin/Fluorouracil for Hepatocellular Carcinoma.

Hepatocellular Carcinoma

Japan
Melissa Pugliano-Mauro
National Cancer Institute (NCI)

Recruiting

Intralesional 5-Fluorouracil (5FU), Topical Imiquimod Treatment for SCC

Carcinoma, Squamous Cell

United States
The Cleveland Clinic
National Cancer Institute (NCI)

Terminated

Combination Therapy With 5-Fluorouracil and Photodynamic Therapy in Post-transplant Premalignant Skin Disease

Actinic Keratosis | Organ or Tissue Transplant; Complications

United States

Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer

A Phase III Randomized Study of 5-Fluorouracil, Mitomycin-C, and Radiotherapy Versus 5-Fluorouracil, Cisplatin, and Radiotherapy in Carcinoma of the Anal Canal

Study Overview

Status

Conditions

Intervention / Treatment

Detailed Description

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Genders Eligible for Study

Description

Study Plan

How is the study designed?

Design Details

Collaborators and Investigators

Sponsor

Collaborators

Investigators

Publications and helpful links

General Publications

Study record dates

Study Major Dates

Study Start

Primary Completion (ACTUAL)

Study Completion (ACTUAL)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (ESTIMATE)

Study Record Updates

Last Update Posted (ESTIMATE)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

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Clinical Trials on Anal Cancer

Clinical Trials on fluorouracil

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