Docetaxel and Immunotherapy Prior to Prostatectomy for High-Risk Prostate Cancer

Inclusion Criteria:

• Patients must have clinical stage 1-3 disease and no radiographic evidence of metastatic disease
• Nomogram Prediction: Patients must have a Kattan nomogram predicted probability of being free from biochemical progression at 5 years after surgery of <60%.

Exclusion Criteria:

• Concurrent or prior treatment with radiation, cytotoxic or biologic therapy for prostate cancer, prior hormonal therapy (except finasteride or dutasteride for obstructive voiding symptoms)
• Male patients unwilling to use effective means of contraception are excluded. Contraception should be continued for 3 months after treatment.
• Prior malignancy will not exclude the patient. (Patients can not have active cancer or be undergoing active treatment). The Principal Investigator will make final decision regarding eligibility since the end point is pathological complete response.