Hypothyroidism in Patients With Type 2 Diabetes With Early Diabetic Nephropathy
Diabetes Mellitus is the most common disorder seen. The impact of this disease on the quality of life, and on morbidity and mortality through the complications that affect the small and large vessels resulting in retinopathy, nephropathy, neuropathy, and ischemic heart disease has been emphasized by the findings of the national commission (USA) on diabetes .
So, there was curiosity to understand and learn the association of this disorder with another common endocrine gland function that is thyroid gland . The association between these two disorders has long been recognized although the prevalence of thyroid dysfunction in diabetic population varies widely between studies. With insulin and thyroid hormone being intimately involved in cellular metabolism and thus excess or deficit of these hormones result in functional derangement of the other.
研究概览
地位
详细说明
Diabetic patients have higher prevalence of thyroid disorder when compared with the normal population. Diabetic women are more frequently affected than men and hypothyroidism is more common than thyrotoxicosis .
Sub-clinical hypothyroidism is an independent risk factor for development of diabetic nephropathy. Severe hypothyroidism (biochemically) may be completely asymptomatic. Though our patient had throid stimulating hormone level more than 100 mIU/L, he did not have any symptoms of hypothyroidism.so diagnosis of hypothyroidism depends on laboratory parameters rather than clinical findings Recognition and treatment of hypothyroidism in diabetic patients will benefit glycemic control and improve general well-being ). Diabetic nephropathy, a major micro-vascular complication of type 2 diabetes mellitus, is an important cause of chronic kidney disease. It results from interactions between hemodynamic and metabolic factors .
研究类型
注册 (预期的)
联系人和位置
学习地点
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Assuit、埃及
- Maria Hamdy
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- All patients with Type 2 diabetes mellitus and with diabetic nephropathy.
- All diabetics irrespective of glucose control.
- All diabetics irrespective of treatment (oral hypoglycemic drugs/insulin)
Exclusion Criteria:
1) Type 1 diabetes mellitus 2) Patients with:
- Gestational diabetes mellitus.
- Pancreatitis.
- Steroid induced Diabetes.
- hepatobiliary disease
- on systemic drug therapy such glucocorticoids and oral contraceptives.
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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3个
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
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percentage of hypothyroidism in patients of type 2 diabetes with diabetic nephropathy
大体时间：one year
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one year
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (预期的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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