Role of PCGEM1 in Breast Cancer
Long Non-coding RNA: PCGEM1 as a Potential Marker for Tumorigenesis in Breast Cancer
研究概览
详细说明
This is an observational, case-control study designed to evaluate the expression of lncRNA PCGEM1 and its association with related molecular pathways, including RhoA, TRIAP1, and ferroptosis, in breast cancer patients. The study will include patients diagnosed with breast cancer and a matched control group.
No intervention will be performed as part of this study. Tissue samples will be obtained from routine diagnostic biopsies that are already indicated as part of standard clinical care, with no additional procedures carried out for research purposes.
Collected tissue samples will be processed for RNA extraction and subsequent molecular analysis to assess gene expression levels. The results will be analyzed to explore the potential role of PCGEM1 in tumor progression and its correlation with selected molecular pathways.
The findings of this study may contribute to a better understanding of breast cancer biology and help identify potential biomarkers or therapeutic targets.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Rehab M Ahmed
- 电话号码：00201003804148
- 邮箱：rehabmostafa998@gmail.com
参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
取样方法
研究人群
描述
Inclusion Criteria:
- Age: 18 years and older.
- Newly diagnosed patients with histopathological confirmation of the diagnosis of breast cancer at any stage.
Exclusion Criteria:
- Presence of any chronic diseases.
- Previous history of breast cancer or other malignancies.
- Evidence of distant metastasis at the time of diagnosis.
- Prior treatment with chemotherapy or radiotherapy.
- Incomplete clinical or laboratory data.
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
female breast cancer patients and matched control - no intervention
|
No intervention will be performed in this study.
Tissue samples will be obtained from routine diagnostic biopsies that are already indicated as part of standard clinical care
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Relative expression level of PCGEM1 marker in breast cancer tissue and blood sample
大体时间：at base line
|
This outcome measures the relative expression level of PCGEM1 in breast cancer tissue and blood samples compared to control using quantitative real-time PCR (qRT-PCR).
The results will be correlated with clinicopathological parameters.
|
at base line
|
合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.