Velocity-Based Resistance Training Effects on Inflammation in Older Adults
2026年5月4日 更新者：National Taipei University
Dose-Response Effects of Velocity-Based Resistance Training on Anti-Inflammatory Responses in Older Adults
This study aims to investigate the effects of resistance training (RT) with different training volumes on immune modulation and anti-inflammatory responses in older adults.
Participants will be randomly assigned to one of three RT volume groups (low, medium, or high) or a non-exercise control group.
Participants in the training groups will complete a 4-week RT program, followed by a 4-week detraining phase.
The findings are expected to provide evidence for volume-specific RT prescriptions to support healthy aging.
研究概览
研究类型
介入性
注册 (估计的)
60
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Shun-Hsi Tsai, Ph.D.
- 电话号码：68523 +88686741111
- 邮箱：shunhsi@mail.ntpu.edu.tw
学习地点
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Taipei、台湾、116
- 招聘中
- National Taiwan Normal University
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接触：
- Hung-Wen Liu, Ph.D.
- 电话号码：+88677496863
- 邮箱：hwliu@ntnu.edu.tw
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接触：
- Kuan-Tsen Yeh, M.S.
- 电话号码：+886932815383
- 邮箱：mickyyehyeh@gmail.com
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
是的
描述
Inclusion Criteria:
- Aged 60-75 years or older
- No regular resistance training habit (defined as ≥2 sessions per week) in the past year
- No musculoskeletal injuries within the past six months
Exclusion Criteria:
- Obesity (BMI > 30 kg/m²), diabetes, hypertension, cancer, heart, kidney, or liver disease, or any other condition that may influence study outcomes.
- Regular use of anti-inflammatory medications (e.g., NSAIDs).
- Smoking or alcohol abuse
- Inability to safely perform the prescribed resistance exercise movements
- Unable to fully comprehend the study information and instructions.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：low training volume resistance exercise
Participants assigned to the low-volume resistance training group will perform one set per exercise at a load corresponding to 80% of 1RM.
Each set will be terminated when movement velocity decreases by 30% from the first repetition.
Rest intervals of 2-3 minutes will be provided between exercises.
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The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions.
All sessions will be supervised by research personnel to ensure proper technique and safety.
Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
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实验性的：medium training volume resistance exercise
Participants assigned to the medium-volume resistance training group will perform three sets per exercise at 80% of 1RM.
Each set will be terminated when movement velocity decreases by 30% relative to the first repetition.
Rest intervals of 90 seconds will be provided between sets, and 2-3 minutes between exercises.
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The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions.
All sessions will be supervised by research personnel to ensure proper technique and safety.
Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
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实验性的：high training volume resistance exercise
Participants assigned to the high-volume resistance training group will perform five sets per exercise at 80% of 1RM.
Each set will be terminated when movement velocity decreases by 30% relative to the first repetition.
Rest intervals of 90 seconds will be provided between sets, and 2-3 minutes between exercises.
|
The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions.
All sessions will be supervised by research personnel to ensure proper technique and safety.
Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
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无干预：sedentary control
Participants in control trial stayed sedentary during the period.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Changes in IL-6 concentration
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Plasma IL-6 concentrations will be measured and reported in pg/mL.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in soluble IL-6 receptor concentration
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Soluble IL-6 receptor concentrations will be measured and reported in ng/mL.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in soluble gp130 concentration
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Soluble gp130 concentrations will be measured and reported in ng/mL.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in IL-10 concentration
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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IL-10 concentrations will be measured and reported in pg/mL.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in IL-1RA concentration
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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IL-1RA concentrations will be measured and reported in pg/mL.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in TNF-α concentration
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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TNF-α concentrations will be measured and reported in pg/mL.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Borgs Ratings of Perceived Exertion (RPE)
大体时间：1-hour during each exercise intervention
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Borgs RPE is a method of estimating exertion rating, based on a 1 to 10 rating scale (1 being the no exertion at all, 10 being maximal exertion).
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1-hour during each exercise intervention
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Handgrip strength
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Maximal handgrip strength will be assessed using a digital hand dynamometer and reported in kilograms.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Knee extension strength
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Maximal voluntary isometric and isokinetic concentric knee extension strength of the dominant leg will be assessed using an isokinetic dynamometer and reported in Newton-meters.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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30-second chair-stand test
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Lower-body functional capacity will be assessed by the number of repetitions completed during a 30-second chair-stand test.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Single-leg balance test
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Balance performance will be assessed as the duration of single-leg stance and reported in seconds.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Timed up and go test
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Functional mobility will be assessed using the Timed Up and Go test, with performance quantified as the time (seconds) required to stand up from a seated position, walk 3 meters, turn, walk back, and sit down.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in SHIP1 protein expression in peripheral blood mononuclear cells (PBMCs)
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Intracellular SHIP1 protein expression in PBMCs will be measured and reported in arbitrary units.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in gp130 (CD130) protein expression in PBMCs
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Intracellular gp130 (CD130) protein expression in PBMCs will be measured and reported in arbitrary units.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in STAT3 protein expression in PBMCs
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Intracellular STAT3 protein expression in PBMCs will be measured and reported in arbitrary units.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in phosphorylated STAT3 protein expression in PBMCs
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Intracellular phosphorylated STAT3 (p-STAT3) protein expression in PBMCs will be measured and reported in arbitrary units.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in IL-6 receptor alpha (CD126) protein expression in PBMCs
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Intracellular IL-6 receptor alpha (CD126) protein expression in PBMCs will be measured and reported in arbitrary units.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in Beta-2 adrenergic receptor (β2-AR) protein expression in PBMCs
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Intracellular β2-adrenergic receptor (β2-AR) protein expression in PBMCs will be measured and reported in arbitrary units.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in SOCS3 protein expression in PBMCs
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Intracellular SOCS3 protein expression in PBMCs will be measured and reported in arbitrary units.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in white blood cell count
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Total white blood cell count will be measured and reported in cells/μL.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in lymphocyte count
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Lymphocyte count will be measured and reported in cells/μL.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in neutrophil count
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Neutrophil count will be measured and reported in cells/μL.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Changes in monocyte count
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Monocyte count will be measured and reported in cells/μL.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Body fat percentage
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Body fat percentage will be measured using a body composition analyzer and reported as a percentage.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Lean body mass
大体时间：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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Total lean body mass will be measured using a body composition analyzer and reported in kilograms.
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Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员：Shun-Hsi Tsai, Ph.D.、National Taipei University
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2026年4月20日
初级完成 (估计的)
2029年3月1日
研究完成 (估计的)
2029年12月1日
研究注册日期
首次提交
2026年4月15日
首先提交符合 QC 标准的
2026年4月28日
首次发布 (实际的)
2026年5月5日
研究记录更新
最后更新发布 (实际的)
2026年5月8日
上次提交的符合 QC 标准的更新
2026年5月4日
最后验证
2026年4月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.