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Velocity-Based Resistance Training Effects on Inflammation in Older Adults

2026年5月4日 更新者：National Taipei University

Dose-Response Effects of Velocity-Based Resistance Training on Anti-Inflammatory Responses in Older Adults

This study aims to investigate the effects of resistance training (RT) with different training volumes on immune modulation and anti-inflammatory responses in older adults. Participants will be randomly assigned to one of three RT volume groups (low, medium, or high) or a non-exercise control group. Participants in the training groups will complete a 4-week RT program, followed by a 4-week detraining phase. The findings are expected to provide evidence for volume-specific RT prescriptions to support healthy aging.

調査の概要

状態

募集

条件

介入・治療

研究の種類

介入

入学 (推定)

60

段階

  • 適用できない

連絡先と場所

このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。

研究連絡先

研究場所

  • 台湾
      • Taipei、台湾、116
        • 募集
        • National Taiwan Normal University
        • コンタクト：
        • コンタクト：

参加基準

研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。

適格基準

就学可能な年齢

  • 大人
  • 高齢者

健康ボランティアの受け入れ

はい

説明

Inclusion Criteria:

  • Aged 60-75 years or older
  • No regular resistance training habit (defined as ≥2 sessions per week) in the past year
  • No musculoskeletal injuries within the past six months

Exclusion Criteria:

  • Obesity (BMI > 30 kg/m²), diabetes, hypertension, cancer, heart, kidney, or liver disease, or any other condition that may influence study outcomes.
  • Regular use of anti-inflammatory medications (e.g., NSAIDs).
  • Smoking or alcohol abuse
  • Inability to safely perform the prescribed resistance exercise movements
  • Unable to fully comprehend the study information and instructions.

研究計画

このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。

研究はどのように設計されていますか？

デザインの詳細

  • 主な目的：処理
  • 割り当て：ランダム化
  • 介入モデル：クロスオーバー割り当て
  • マスキング：なし（オープンラベル）

武器と介入

参加者グループ / アーム
介入・治療
実験的：low training volume resistance exercise
Participants assigned to the low-volume resistance training group will perform one set per exercise at a load corresponding to 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% from the first repetition. Rest intervals of 2-3 minutes will be provided between exercises.
他の：Resistance exercise
The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
実験的：medium training volume resistance exercise
Participants assigned to the medium-volume resistance training group will perform three sets per exercise at 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% relative to the first repetition. Rest intervals of 90 seconds will be provided between sets, and 2-3 minutes between exercises.
他の：Resistance exercise
The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
実験的：high training volume resistance exercise
Participants assigned to the high-volume resistance training group will perform five sets per exercise at 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% relative to the first repetition. Rest intervals of 90 seconds will be provided between sets, and 2-3 minutes between exercises.
他の：Resistance exercise
The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
介入なし：sedentary control
Participants in control trial stayed sedentary during the period.

この研究は何を測定していますか？

主要な結果の測定

結果測定
メジャーの説明
時間枠
Changes in IL-6 concentration
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Plasma IL-6 concentrations will be measured and reported in pg/mL.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in soluble IL-6 receptor concentration
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Soluble IL-6 receptor concentrations will be measured and reported in ng/mL.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in soluble gp130 concentration
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Soluble gp130 concentrations will be measured and reported in ng/mL.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in IL-10 concentration
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
IL-10 concentrations will be measured and reported in pg/mL.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in IL-1RA concentration
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
IL-1RA concentrations will be measured and reported in pg/mL.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in TNF-α concentration
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
TNF-α concentrations will be measured and reported in pg/mL.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

二次結果の測定

結果測定
メジャーの説明
時間枠
Borgs Ratings of Perceived Exertion (RPE)
時間枠：1-hour during each exercise intervention
Borgs RPE is a method of estimating exertion rating, based on a 1 to 10 rating scale (1 being the no exertion at all, 10 being maximal exertion).
1-hour during each exercise intervention
Handgrip strength
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Maximal handgrip strength will be assessed using a digital hand dynamometer and reported in kilograms.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Knee extension strength
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Maximal voluntary isometric and isokinetic concentric knee extension strength of the dominant leg will be assessed using an isokinetic dynamometer and reported in Newton-meters.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
30-second chair-stand test
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Lower-body functional capacity will be assessed by the number of repetitions completed during a 30-second chair-stand test.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Single-leg balance test
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Balance performance will be assessed as the duration of single-leg stance and reported in seconds.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Timed up and go test
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Functional mobility will be assessed using the Timed Up and Go test, with performance quantified as the time (seconds) required to stand up from a seated position, walk 3 meters, turn, walk back, and sit down.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in SHIP1 protein expression in peripheral blood mononuclear cells (PBMCs)
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Intracellular SHIP1 protein expression in PBMCs will be measured and reported in arbitrary units.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in gp130 (CD130) protein expression in PBMCs
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Intracellular gp130 (CD130) protein expression in PBMCs will be measured and reported in arbitrary units.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in STAT3 protein expression in PBMCs
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Intracellular STAT3 protein expression in PBMCs will be measured and reported in arbitrary units.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in phosphorylated STAT3 protein expression in PBMCs
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Intracellular phosphorylated STAT3 (p-STAT3) protein expression in PBMCs will be measured and reported in arbitrary units.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in IL-6 receptor alpha (CD126) protein expression in PBMCs
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Intracellular IL-6 receptor alpha (CD126) protein expression in PBMCs will be measured and reported in arbitrary units.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in Beta-2 adrenergic receptor (β2-AR) protein expression in PBMCs
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Intracellular β2-adrenergic receptor (β2-AR) protein expression in PBMCs will be measured and reported in arbitrary units.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in SOCS3 protein expression in PBMCs
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Intracellular SOCS3 protein expression in PBMCs will be measured and reported in arbitrary units.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in white blood cell count
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Total white blood cell count will be measured and reported in cells/μL.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in lymphocyte count
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Lymphocyte count will be measured and reported in cells/μL.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in neutrophil count
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Neutrophil count will be measured and reported in cells/μL.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in monocyte count
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Monocyte count will be measured and reported in cells/μL.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Body fat percentage
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Body fat percentage will be measured using a body composition analyzer and reported as a percentage.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Lean body mass
時間枠：Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Total lean body mass will be measured using a body composition analyzer and reported in kilograms.
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

協力者と研究者

ここでは、この調査に関係する人々や組織を見つけることができます。

スポンサー

National Taipei University

捜査官

  • 主任研究者：Shun-Hsi Tsai, Ph.D.、National Taipei University

研究記録日

これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。

主要日程の研究

研究開始 (実際)

2026年4月20日

一次修了 (推定)

2029年3月1日

研究の完了 (推定)

2029年12月1日

試験登録日

最初に提出

2026年4月15日

QC基準を満たした最初の提出物

2026年4月28日

最初の投稿 (実際)

2026年5月5日

学習記録の更新

投稿された最後の更新 (実際)

2026年5月8日

QC基準を満たした最後の更新が送信されました

2026年5月4日

最終確認日

2026年4月1日

詳しくは

本研究に関する用語

追加の関連 MeSH 用語

その他の研究ID番号

  • ECKIRB1140803

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いいえ

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