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Velocity-Based Resistance Training Effects on Inflammation in Older Adults

2026년 5월 4일 업데이트: National Taipei University

Dose-Response Effects of Velocity-Based Resistance Training on Anti-Inflammatory Responses in Older Adults

This study aims to investigate the effects of resistance training (RT) with different training volumes on immune modulation and anti-inflammatory responses in older adults. Participants will be randomly assigned to one of three RT volume groups (low, medium, or high) or a non-exercise control group. Participants in the training groups will complete a 4-week RT program, followed by a 4-week detraining phase. The findings are expected to provide evidence for volume-specific RT prescriptions to support healthy aging.

연구 개요

상태

모병

정황

개입 / 치료

다른: Resistance exercise

연구 유형

중재적

등록 (추정된)

단계

해당 없음

연락처 및 위치

이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.

연구 연락처

이름: Shun-Hsi Tsai, Ph.D.
전화번호: 68523 +88686741111
이메일: shunhsi@mail.ntpu.edu.tw

연구 장소

대만
- - Taipei, 대만, 116
    - 모병
    - National Taiwan Normal University
    - 연락하다:
      
      Hung-Wen Liu, Ph.D.
      
      전화번호: +88677496863
      
      이메일: hwliu@ntnu.edu.tw
    - 연락하다:
      
      Kuan-Tsen Yeh, M.S.
      
      전화번호: +886932815383
      
      이메일: mickyyehyeh@gmail.com

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

성인
고령자

건강한 자원 봉사자를 받아들입니다

예

설명

Inclusion Criteria:

Aged 60-75 years or older
No regular resistance training habit (defined as ≥2 sessions per week) in the past year
No musculoskeletal injuries within the past six months

Exclusion Criteria:

Obesity (BMI > 30 kg/m²), diabetes, hypertension, cancer, heart, kidney, or liver disease, or any other condition that may influence study outcomes.
Regular use of anti-inflammatory medications (e.g., NSAIDs).
Smoking or alcohol abuse
Inability to safely perform the prescribed resistance exercise movements
Unable to fully comprehend the study information and instructions.

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

주 목적: 치료
할당: 무작위
중재 모델: 크로스오버 할당
마스킹: 없음(오픈 라벨)

팔의 수

무기와 개입

참가자 그룹 / 팔	개입 / 치료
실험적: low training volume resistance exercise Participants assigned to the low-volume resistance training group will perform one set per exercise at a load corresponding to 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% from the first repetition. Rest intervals of 2-3 minutes will be provided between exercises.	다른: Resistance exercise The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
실험적: medium training volume resistance exercise Participants assigned to the medium-volume resistance training group will perform three sets per exercise at 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% relative to the first repetition. Rest intervals of 90 seconds will be provided between sets, and 2-3 minutes between exercises.	다른: Resistance exercise The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
실험적: high training volume resistance exercise Participants assigned to the high-volume resistance training group will perform five sets per exercise at 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% relative to the first repetition. Rest intervals of 90 seconds will be provided between sets, and 2-3 minutes between exercises.	다른: Resistance exercise The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
간섭 없음: sedentary control Participants in control trial stayed sedentary during the period.

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정	측정값 설명	기간
Changes in IL-6 concentration 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Plasma IL-6 concentrations will be measured and reported in pg/mL.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in soluble IL-6 receptor concentration 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Soluble IL-6 receptor concentrations will be measured and reported in ng/mL.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in soluble gp130 concentration 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Soluble gp130 concentrations will be measured and reported in ng/mL.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in IL-10 concentration 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	IL-10 concentrations will be measured and reported in pg/mL.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in IL-1RA concentration 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	IL-1RA concentrations will be measured and reported in pg/mL.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in TNF-α concentration 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	TNF-α concentrations will be measured and reported in pg/mL.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

2차 결과 측정

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

스폰서

National Taipei University

수사관

수석 연구원: Shun-Hsi Tsai, Ph.D., National Taipei University

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (실제)

2026년 4월 20일

기본 완료 (추정된)

2029년 3월 1일

연구 완료 (추정된)

2029년 12월 1일

연구 등록 날짜

최초 제출

2026년 4월 15일

QC 기준을 충족하는 최초 제출

2026년 4월 28일

처음 게시됨 (실제)

2026년 5월 5일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2026년 5월 8일

QC 기준을 충족하는 마지막 업데이트 제출

2026년 5월 4일

마지막으로 확인됨

2026년 4월 1일

추가 정보

이 연구와 관련된 용어

추가 관련 MeSH 약관

기타 연구 ID 번호

ECKIRB1140803

개별 참가자 데이터(IPD) 계획

개별 참가자 데이터(IPD)를 공유할 계획입니까?

아니요

약물 및 장치 정보, 연구 문서

미국 FDA 규제 의약품 연구

아니

미국 FDA 규제 기기 제품 연구

아니

이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .

Resistance exercise에 대한 임상 시험

AHS Cancer Control Alberta

완전한

림프부종에 대한 운동과 압박 (DREAM)

유방암 관련 림프부종

캐나다
New York Institute of Technology

모집하지 않고 적극적으로

상체 체력 향상을 위한 운동 스낵 활용

근력 | 육체적 지구력 | 근력

미국
University of Toronto
University Health Network, Toronto; University of Western Ontario, Canada; Institute for... 그리고 다른 협력자들

완전한

그룹, 작업 중심의 커뮤니티 기반 운동 프로그램이 뇌졸중 환자의 일상 기능을 향상합니까?

뇌졸중 | 일상생활 활동 | 이동성 제한 | 균형

캐나다
Federal University of Health Science of Porto Alegre

완전한

CABG 수술 후 심장 재활과 관련된 흡기 근육 훈련의 효과

심혈관 질환

브라질
Cukurova University

완전한

구조화된 운동 프로그램이 ADHD 아동의 인지, 운동 및 행동 결과에 미치는 영향 (ADHD)

주의력 결핍 과잉 행동 장애(ADHD)

터키 (Türkiye)
The Hong Kong Polytechnic University

완전한

메시징 앱 리마인더가 ZTEx(Zero-Time Exercise) 준수에 미치는 영향

불면증, 원발성

홍콩
McMaster University

아직 모집하지 않음

파트너4운동 무작위 대조 시험 (P4E RCT)

암

캐나다
Oregon Research Institute

모집하지 않고 적극적으로

경도인지장애 노인의 태극권과 인지기능

가벼운 인지 장애

미국
University of Maryland, Baltimore
National Institute on Aging (NIA)

완전한

BHS5 - 운동 플러스 프로그램의 효과 테스트 (Hip5)

고관절 골절

미국
Gulf Medical University

완전한

어깨 통증에서 힘줄부하와 저항운동을 이용한 SEP운동과 SSMP운동의 비교.

견봉하 통증 증후군

아랍 에미리트

결과 측정	측정값 설명	기간
Borgs Ratings of Perceived Exertion (RPE) 기간: 1-hour during each exercise intervention	Borgs RPE is a method of estimating exertion rating, based on a 1 to 10 rating scale (1 being the no exertion at all, 10 being maximal exertion).	1-hour during each exercise intervention
Handgrip strength 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Maximal handgrip strength will be assessed using a digital hand dynamometer and reported in kilograms.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Knee extension strength 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Maximal voluntary isometric and isokinetic concentric knee extension strength of the dominant leg will be assessed using an isokinetic dynamometer and reported in Newton-meters.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
30-second chair-stand test 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Lower-body functional capacity will be assessed by the number of repetitions completed during a 30-second chair-stand test.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Single-leg balance test 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Balance performance will be assessed as the duration of single-leg stance and reported in seconds.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Timed up and go test 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Functional mobility will be assessed using the Timed Up and Go test, with performance quantified as the time (seconds) required to stand up from a seated position, walk 3 meters, turn, walk back, and sit down.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in SHIP1 protein expression in peripheral blood mononuclear cells (PBMCs) 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Intracellular SHIP1 protein expression in PBMCs will be measured and reported in arbitrary units.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in gp130 (CD130) protein expression in PBMCs 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Intracellular gp130 (CD130) protein expression in PBMCs will be measured and reported in arbitrary units.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in STAT3 protein expression in PBMCs 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Intracellular STAT3 protein expression in PBMCs will be measured and reported in arbitrary units.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in phosphorylated STAT3 protein expression in PBMCs 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Intracellular phosphorylated STAT3 (p-STAT3) protein expression in PBMCs will be measured and reported in arbitrary units.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in IL-6 receptor alpha (CD126) protein expression in PBMCs 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Intracellular IL-6 receptor alpha (CD126) protein expression in PBMCs will be measured and reported in arbitrary units.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in Beta-2 adrenergic receptor (β2-AR) protein expression in PBMCs 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Intracellular β2-adrenergic receptor (β2-AR) protein expression in PBMCs will be measured and reported in arbitrary units.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in SOCS3 protein expression in PBMCs 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Intracellular SOCS3 protein expression in PBMCs will be measured and reported in arbitrary units.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in white blood cell count 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Total white blood cell count will be measured and reported in cells/μL.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in lymphocyte count 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Lymphocyte count will be measured and reported in cells/μL.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in neutrophil count 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Neutrophil count will be measured and reported in cells/μL.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Changes in monocyte count 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Monocyte count will be measured and reported in cells/μL.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Body fat percentage 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Body fat percentage will be measured using a body composition analyzer and reported as a percentage.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining
Lean body mass 기간: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining	Total lean body mass will be measured using a body composition analyzer and reported in kilograms.	Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

Velocity-Based Resistance Training Effects on Inflammation in Older Adults

Dose-Response Effects of Velocity-Based Resistance Training on Anti-Inflammatory Responses in Older Adults

연구 개요

상태

정황

개입 / 치료

연구 유형

등록 (추정된)

단계

연락처 및 위치

연구 연락처

연구 장소

참여기준

자격 기준

공부할 수 있는 나이

건강한 자원 봉사자를 받아들입니다

설명

공부 계획

연구는 어떻게 설계됩니까?

디자인 세부사항

팔의 수

무기와 개입

참가자 그룹 / 팔

개입 / 치료

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정

측정값 설명

기간

2차 결과 측정

결과 측정

측정값 설명

기간

공동 작업자 및 조사자

스폰서

수사관

연구 기록 날짜

연구 주요 날짜

연구 시작 (실제)

기본 완료 (추정된)

연구 완료 (추정된)

연구 등록 날짜

최초 제출

QC 기준을 충족하는 최초 제출

처음 게시됨 (실제)

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

QC 기준을 충족하는 마지막 업데이트 제출

마지막으로 확인됨

추가 정보

이 연구와 관련된 용어

추가 관련 MeSH 약관

기타 연구 ID 번호

개별 참가자 데이터(IPD) 계획

개별 참가자 데이터(IPD)를 공유할 계획입니까?

약물 및 장치 정보, 연구 문서

미국 FDA 규제 의약품 연구

미국 FDA 규제 기기 제품 연구

Resistance exercise에 대한 임상 시험

유사한 임상시험 검색

스폰서 및 공동 작업자

건강 상태

약물 개입

CROs by country

CROs in Guatemala

정황

희귀 질병

약물 개입

식이 보충제

스폰서 / 협력자

위치