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Comparison of Artificial Intelligence and Clinicians With Different Experience Levels in Assessing Gingival Phenotype

2026年5月6日 更新者:Sude Yildirim、Ondokuz Mayıs University

The goal of this observational study is to compare the performance of clinicians with different experience levels and a deep learning-based artificial intelligence (AI) model in assessing gingival phenotype using two diagnostic methods: the periodontal probe transparency method and visual assessment from standardized clinical photographs. The main questions the study aims to answer are:

Can AI achieve comparable accuracy to human examiners in both probe transparency and visual assessment methods?

Does examiner experience level influence diagnostic performance and agreement with the reference standard in these methods?

Researchers will compare AI, dental students, and periodontology research assistants to determine accuracy, sensitivity, specificity, and agreement with the gold standard for each method.

Participants will:

Undergo standardized intraoral photography of maxillary anterior teeth, with and without a periodontal probe in place, following a validated protocol.

Have gingival phenotype determined by a reference periodontologist using the probe transparency method as the gold standard.

Have their photographs evaluated by AI, dental students, and research assistants for phenotype classification using both methods.

研究概览

详细说明

Gingival phenotype, representing the thickness and morphological characteristics of the gingival soft tissues, plays a critical role in periodontal health, treatment planning, and the long-term stability of clinical outcomes. A thin phenotype is associated with increased risk of gingival recession, papilla loss, and inflammatory complications, while a thick phenotype offers better soft tissue stability but may mask inflammation. Accurate and reproducible assessment of gingival phenotype is therefore essential in clinical dentistry.

The periodontal probe transparency method is considered the gold standard for phenotype assessment due to its simplicity and non-invasiveness. In this method, a periodontal probe is inserted into the sulcus from the buccal aspect, and if the probe is visible through the gingival tissue, the phenotype is classified as thin; if not visible, it is classified as thick. However, the method is susceptible to variability depending on examiner experience, lighting conditions, and subjective interpretation.

Visual assessment, which relies solely on the inspection of gingival and tooth morphology in photographs without a probe, offers a non-contact alternative but is similarly subject to examiner-related variability. These limitations highlight the need for standardized and objective approaches to phenotype determination.

Artificial intelligence (AI), particularly deep learning-based image analysis, has shown promising results in dental diagnostics, enabling automated classification of clinical images with high accuracy and reproducibility. In periodontal research, AI has been applied for lesion detection and radiographic interpretation, but its application in gingival phenotype assessment-especially using the probe transparency method and visual assessment-remains unexplored.

This observational study aims to compare the diagnostic performance of a deep learning-based AI model with human examiners of different experience levels (periodontology residents vs. dental students) in assessing gingival phenotype from standardized intraoral photographs using both the periodontal probe transparency method and visual assessment. The reference standard will be the classification provided by an experienced periodontologist using the probe transparency method in a clinical setting.

The study will evaluate and compare accuracy, sensitivity, specificity, and inter-/intra-examiner agreement across examiner groups and the AI model. The findings are expected to provide insights into the potential of AI as a standardizing tool, reducing inter-examiner variability and supporting clinical decision-making, particularly for less experienced clinicians. Additionally, the study may inform the integration of AI-assisted diagnostic tools in dental education and practice, improving training efficiency and clinical outcomes.

研究类型

观察性的

注册 (估计的)

40

联系人和位置

本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。

学习联系方式

参与标准

研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人
  • 年长者

接受健康志愿者

是的

取样方法

非概率样本

研究人群

The study population will consist of systemically and periodontally healthy adults attending the Department of Periodontology at Ondokuz Mayıs University, Faculty of Dentistry, for routine dental care or check-up. Eligible participants will have natural maxillary anterior incisors and meet all inclusion criteria.

Additionally, the examiner population will include:

Periodontology research assistants currently working in the department.

Fourth- and fifth-year dental intern students who have completed the periodontology clinical rotation.

描述

Inclusion Criteria for Volunteer Participants Who Will Participate in Transparency and Visual Assessment:

  • Systemically and periodontally healthy individuals.
  • Presence of natural maxillary anterior incisors.

Exclusion Criteria:

  • Presence of fixed crowns or cervical restorations on the evaluated teeth.
  • Pregnant or breastfeeding women.
  • Signs of gingival inflammation or periodontal disease with attachment loss.
  • Presence of buccal gingival recession.
  • Use of medications known to cause gingival enlargement.
  • Presence of congenital anomalies or dental structural defects.

Inclusion Criteria for Clinicians:

  • Research assistants: Must be currently working in the Department of Periodontology.
  • Dental Intern Students: Fourth- or fifth-year students who have completed periodontology clinical rotation.

Exclusion Criteria for Clinicians:

  • Those who are confirmed to be color blind by the Ishihara test

学习计划

本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。

研究是如何设计的?

设计细节

队列和干预

团体/队列
干预/治疗
Dental Students
Fourth- and fifth-year dental intern students will assess standardized intraoral photographs using both the periodontal probe transparency method and visual assessment to classify gingival phenotype.
Standardized intraoral photography of the maxillary anterior teeth with a periodontal probe placed according to the transparency method protocol to determine probe visibility status.
Standardized intraoral photography of the maxillary anterior teeth without a periodontal probe, evaluated for gingival phenotype classification based on morphological features.
Artificial Intelligence Model
A deep learning-based image classification model will analyze standardized intraoral photographs, detecting probe visibility and classifying gingival phenotype according to the periodontal probe transparency method and visual assessment criteria.
Standardized intraoral photography of the maxillary anterior teeth with a periodontal probe placed according to the transparency method protocol to determine probe visibility status.
Standardized intraoral photography of the maxillary anterior teeth without a periodontal probe, evaluated for gingival phenotype classification based on morphological features.
A deep learning image classification algorithm trained to assess probe visibility and gingival phenotype from standardized intraoral photographs.
Periodontology Research Assistants
Research assistants in periodontology will assess standardized intraoral photographs using both the periodontal probe transparency method and visual assessment to classify gingival phenotype.
Standardized intraoral photography of the maxillary anterior teeth with a periodontal probe placed according to the transparency method protocol to determine probe visibility status.
Standardized intraoral photography of the maxillary anterior teeth without a periodontal probe, evaluated for gingival phenotype classification based on morphological features.

研究衡量的是什么?

主要结果指标

结果测量
措施说明
大体时间
Diagnostic Accuracy of Each Examiner Group and AI Model in the Periodontal Probe Transparency Method
大体时间:At the time of image evaluation (single session).

Accuracy in determining probe visibility (visible vs. not visible) compared to the gold standard classification by an experienced periodontologist.

Measure Type: Proportion (%). Analysis: Accuracy, sensitivity, specificity, and Cohen's kappa coefficient will be calculated.

At the time of image evaluation (single session).

次要结果测量

结果测量
措施说明
大体时间
Diagnostic Accuracy of Each Examiner Group and AI Model in Visual Assessment Method
大体时间:At the time of image evaluation (single session).

Accuracy in classifying gingival phenotype (thin vs. thick) without probe, compared to the gold standard classification.

Measure Type: Proportion (%).

At the time of image evaluation (single session).
Agreement Between Examiner Groups and AI Model
大体时间:At the time of image evaluation and at 2-week retest (for a random subset of evaluators).
Inter-examiner and intra-examiner agreement for each method, evaluated using Cohen's kappa coefficient and intraclass correlation coefficient (ICC).
At the time of image evaluation and at 2-week retest (for a random subset of evaluators).
Effect of Examiner Experience Level on Diagnostic Performance
大体时间:At the time of image evaluation (single session).

Comparison of accuracy and agreement between research assistants and dental intern students for each method.

Proportion (%), agreement statistic.

At the time of image evaluation (single session).

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年5月15日

初级完成 (估计的)

2026年8月15日

研究完成 (估计的)

2026年10月15日

研究注册日期

首次提交

2026年4月29日

首先提交符合 QC 标准的

2026年4月29日

首次发布 (实际的)

2026年5月6日

研究记录更新

最后更新发布 (实际的)

2026年5月11日

上次提交的符合 QC 标准的更新

2026年5月6日

最后验证

2026年5月1日

更多信息

与本研究相关的术语

其他研究编号

  • OMUKAEK NO:225/335

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)?

是的

IPD 计划说明

De-identified individual participant data (IPD), including demographic characteristics, periodontal measurements, and standardized intraoral photographs, may be shared upon reasonable request for academic purposes. Access will require a data use agreement and approval by the principal investigator.

IPD 共享时间框架

De-identified IPD and supporting documents will be available within 12 months after publication of the main results and will remain available for at least 5 years.

IPD 共享访问标准

https://www.icmje.org/recommendations/browse/publishing-and-editorial-issues/clinical-trial-registration.html

IPD 共享支持信息类型

  • 研究方案
  • 树液
  • 国际碳纤维联合会

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.

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