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Comparison of Artificial Intelligence and Clinicians With Different Experience Levels in Assessing Gingival Phenotype

6. Mai 2026 aktualisiert von: Sude Yildirim, Ondokuz Mayıs University

The goal of this observational study is to compare the performance of clinicians with different experience levels and a deep learning-based artificial intelligence (AI) model in assessing gingival phenotype using two diagnostic methods: the periodontal probe transparency method and visual assessment from standardized clinical photographs. The main questions the study aims to answer are:

Can AI achieve comparable accuracy to human examiners in both probe transparency and visual assessment methods?

Does examiner experience level influence diagnostic performance and agreement with the reference standard in these methods?

Researchers will compare AI, dental students, and periodontology research assistants to determine accuracy, sensitivity, specificity, and agreement with the gold standard for each method.

Participants will:

Undergo standardized intraoral photography of maxillary anterior teeth, with and without a periodontal probe in place, following a validated protocol.

Have gingival phenotype determined by a reference periodontologist using the probe transparency method as the gold standard.

Have their photographs evaluated by AI, dental students, and research assistants for phenotype classification using both methods.

Studienübersicht

Detaillierte Beschreibung

Gingival phenotype, representing the thickness and morphological characteristics of the gingival soft tissues, plays a critical role in periodontal health, treatment planning, and the long-term stability of clinical outcomes. A thin phenotype is associated with increased risk of gingival recession, papilla loss, and inflammatory complications, while a thick phenotype offers better soft tissue stability but may mask inflammation. Accurate and reproducible assessment of gingival phenotype is therefore essential in clinical dentistry.

The periodontal probe transparency method is considered the gold standard for phenotype assessment due to its simplicity and non-invasiveness. In this method, a periodontal probe is inserted into the sulcus from the buccal aspect, and if the probe is visible through the gingival tissue, the phenotype is classified as thin; if not visible, it is classified as thick. However, the method is susceptible to variability depending on examiner experience, lighting conditions, and subjective interpretation.

Visual assessment, which relies solely on the inspection of gingival and tooth morphology in photographs without a probe, offers a non-contact alternative but is similarly subject to examiner-related variability. These limitations highlight the need for standardized and objective approaches to phenotype determination.

Artificial intelligence (AI), particularly deep learning-based image analysis, has shown promising results in dental diagnostics, enabling automated classification of clinical images with high accuracy and reproducibility. In periodontal research, AI has been applied for lesion detection and radiographic interpretation, but its application in gingival phenotype assessment-especially using the probe transparency method and visual assessment-remains unexplored.

This observational study aims to compare the diagnostic performance of a deep learning-based AI model with human examiners of different experience levels (periodontology residents vs. dental students) in assessing gingival phenotype from standardized intraoral photographs using both the periodontal probe transparency method and visual assessment. The reference standard will be the classification provided by an experienced periodontologist using the probe transparency method in a clinical setting.

The study will evaluate and compare accuracy, sensitivity, specificity, and inter-/intra-examiner agreement across examiner groups and the AI model. The findings are expected to provide insights into the potential of AI as a standardizing tool, reducing inter-examiner variability and supporting clinical decision-making, particularly for less experienced clinicians. Additionally, the study may inform the integration of AI-assisted diagnostic tools in dental education and practice, improving training efficiency and clinical outcomes.

Studientyp

Beobachtungs

Einschreibung (Geschätzt)

40

Kontakte und Standorte

Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.

Studienkontakt

Teilnahmekriterien

Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.

Zulassungskriterien

Studienberechtigtes Alter

  • Erwachsene
  • Älterer Erwachsener

Akzeptiert gesunde Freiwillige

Ja

Probenahmeverfahren

Nicht-Wahrscheinlichkeitsprobe

Studienpopulation

The study population will consist of systemically and periodontally healthy adults attending the Department of Periodontology at Ondokuz Mayıs University, Faculty of Dentistry, for routine dental care or check-up. Eligible participants will have natural maxillary anterior incisors and meet all inclusion criteria.

Additionally, the examiner population will include:

Periodontology research assistants currently working in the department.

Fourth- and fifth-year dental intern students who have completed the periodontology clinical rotation.

Beschreibung

Inclusion Criteria for Volunteer Participants Who Will Participate in Transparency and Visual Assessment:

  • Systemically and periodontally healthy individuals.
  • Presence of natural maxillary anterior incisors.

Exclusion Criteria:

  • Presence of fixed crowns or cervical restorations on the evaluated teeth.
  • Pregnant or breastfeeding women.
  • Signs of gingival inflammation or periodontal disease with attachment loss.
  • Presence of buccal gingival recession.
  • Use of medications known to cause gingival enlargement.
  • Presence of congenital anomalies or dental structural defects.

Inclusion Criteria for Clinicians:

  • Research assistants: Must be currently working in the Department of Periodontology.
  • Dental Intern Students: Fourth- or fifth-year students who have completed periodontology clinical rotation.

Exclusion Criteria for Clinicians:

  • Those who are confirmed to be color blind by the Ishihara test

Studienplan

Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.

Wie ist die Studie aufgebaut?

Designdetails

Kohorten und Interventionen

Gruppe / Kohorte
Intervention / Behandlung
Dental Students
Fourth- and fifth-year dental intern students will assess standardized intraoral photographs using both the periodontal probe transparency method and visual assessment to classify gingival phenotype.
Standardized intraoral photography of the maxillary anterior teeth with a periodontal probe placed according to the transparency method protocol to determine probe visibility status.
Standardized intraoral photography of the maxillary anterior teeth without a periodontal probe, evaluated for gingival phenotype classification based on morphological features.
Artificial Intelligence Model
A deep learning-based image classification model will analyze standardized intraoral photographs, detecting probe visibility and classifying gingival phenotype according to the periodontal probe transparency method and visual assessment criteria.
Standardized intraoral photography of the maxillary anterior teeth with a periodontal probe placed according to the transparency method protocol to determine probe visibility status.
Standardized intraoral photography of the maxillary anterior teeth without a periodontal probe, evaluated for gingival phenotype classification based on morphological features.
A deep learning image classification algorithm trained to assess probe visibility and gingival phenotype from standardized intraoral photographs.
Periodontology Research Assistants
Research assistants in periodontology will assess standardized intraoral photographs using both the periodontal probe transparency method and visual assessment to classify gingival phenotype.
Standardized intraoral photography of the maxillary anterior teeth with a periodontal probe placed according to the transparency method protocol to determine probe visibility status.
Standardized intraoral photography of the maxillary anterior teeth without a periodontal probe, evaluated for gingival phenotype classification based on morphological features.

Was misst die Studie?

Primäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Diagnostic Accuracy of Each Examiner Group and AI Model in the Periodontal Probe Transparency Method
Zeitfenster: At the time of image evaluation (single session).

Accuracy in determining probe visibility (visible vs. not visible) compared to the gold standard classification by an experienced periodontologist.

Measure Type: Proportion (%). Analysis: Accuracy, sensitivity, specificity, and Cohen's kappa coefficient will be calculated.

At the time of image evaluation (single session).

Sekundäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Diagnostic Accuracy of Each Examiner Group and AI Model in Visual Assessment Method
Zeitfenster: At the time of image evaluation (single session).

Accuracy in classifying gingival phenotype (thin vs. thick) without probe, compared to the gold standard classification.

Measure Type: Proportion (%).

At the time of image evaluation (single session).
Agreement Between Examiner Groups and AI Model
Zeitfenster: At the time of image evaluation and at 2-week retest (for a random subset of evaluators).
Inter-examiner and intra-examiner agreement for each method, evaluated using Cohen's kappa coefficient and intraclass correlation coefficient (ICC).
At the time of image evaluation and at 2-week retest (for a random subset of evaluators).
Effect of Examiner Experience Level on Diagnostic Performance
Zeitfenster: At the time of image evaluation (single session).

Comparison of accuracy and agreement between research assistants and dental intern students for each method.

Proportion (%), agreement statistic.

At the time of image evaluation (single session).

Mitarbeiter und Ermittler

Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.

Publikationen und hilfreiche Links

Die Bereitstellung dieser Publikationen erfolgt freiwillig durch die für die Eingabe von Informationen über die Studie verantwortliche Person. Diese können sich auf alles beziehen, was mit dem Studium zu tun hat.

Studienaufzeichnungsdaten

Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.

Haupttermine studieren

Studienbeginn (Geschätzt)

15. Mai 2026

Primärer Abschluss (Geschätzt)

15. August 2026

Studienabschluss (Geschätzt)

15. Oktober 2026

Studienanmeldedaten

Zuerst eingereicht

29. April 2026

Zuerst eingereicht, das die QC-Kriterien erfüllt hat

29. April 2026

Zuerst gepostet (Tatsächlich)

6. Mai 2026

Studienaufzeichnungsaktualisierungen

Letztes Update gepostet (Tatsächlich)

11. Mai 2026

Letztes eingereichtes Update, das die QC-Kriterien erfüllt

6. Mai 2026

Zuletzt verifiziert

1. Mai 2026

Mehr Informationen

Begriffe im Zusammenhang mit dieser Studie

Andere Studien-ID-Nummern

  • OMUKAEK NO:225/335

Plan für individuelle Teilnehmerdaten (IPD)

Planen Sie, individuelle Teilnehmerdaten (IPD) zu teilen?

JA

Beschreibung des IPD-Plans

De-identified individual participant data (IPD), including demographic characteristics, periodontal measurements, and standardized intraoral photographs, may be shared upon reasonable request for academic purposes. Access will require a data use agreement and approval by the principal investigator.

IPD-Sharing-Zeitrahmen

De-identified IPD and supporting documents will be available within 12 months after publication of the main results and will remain available for at least 5 years.

IPD-Sharing-Zugriffskriterien

https://www.icmje.org/recommendations/browse/publishing-and-editorial-issues/clinical-trial-registration.html

Art der unterstützenden IPD-Freigabeinformationen

  • STUDIENPROTOKOLL
  • SAFT
  • ICF

Arzneimittel- und Geräteinformationen, Studienunterlagen

Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt

Nein

Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt

Nein

Diese Informationen wurden ohne Änderungen direkt von der Website clinicaltrials.gov abgerufen. Wenn Sie Ihre Studiendaten ändern, entfernen oder aktualisieren möchten, wenden Sie sich bitte an register@clinicaltrials.gov. Sobald eine Änderung auf clinicaltrials.gov implementiert wird, wird diese automatisch auch auf unserer Website aktualisiert .

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