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Acute Kidney Injury in Upper GI Bleeding Patients

2026年6月4日 更新者：Walaa Abdelrahim Abdelfattah、Sohag University

Acute Kidney Injury Following Upper Gastrointestinal Bleeding: Incidence and Predictors

This study aims to evaluate the incidence of acute kidney injury (AKI) among patients presenting with acute upper gastrointestinal bleeding (UGIB) at Sohag University Hospitals, and to identify predictors associated with renal impairment in these patients.

研究概览

地位

尚未招聘

条件

干预/治疗

详细说明

Upper gastrointestinal bleeding (UGIB) is a common medical emergency associated with significant morbidity and mortality. Acute kidney injury (AKI) is frequently observed in these patients, mainly due to hypovolemia and renal hypoperfusion. Despite its clinical importance, data regarding AKI incidence and predictors in UGIB patients, particularly in Middle Eastern populations, remain limited.

This prospective observational study aims to assess renal function abnormalities and identify predictors of AKI in patients with UGIB, including both variceal and non-variceal causes. The study will also evaluate clinical outcomes such as mortality, hospital stay duration, and need for renal replacement therapy.

研究类型

观察性的

注册 (估计的)

200

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 埃及
      • Sohag、埃及
        • Sohag University Hospitals

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人
  • 年长者

接受健康志愿者

不

取样方法

非概率样本

研究人群

Adult patients presenting with acute upper gastrointestinal bleeding and admitted to Sohag University Hospitals, including both ward and ICU patients, who meet the eligibility criteria and have available renal function data.

描述

Inclusion Criteria:

  • Adult patients aged 18 years or older
  • Patients presenting with clinical features suggestive of acute upper gastrointestinal bleeding (UGIB), including hematemesis, coffee-ground vomiting, or melena
  • Diagnosis of UGIB confirmed by upper gastrointestinal endoscopy or strong clinical evidence when endoscopy is not immediately available
  • Patients admitted to Sohag University Hospitals (medical wards or intensive care unit)
  • Availability of renal function data, including at least one serum creatinine measurement at admission and serial measurements during hospitalization
  • Availability of baseline renal function (previous serum creatinine within 3-12 months) or estimable baseline during hospitalization

Exclusion Criteria:

  • Patients with end-stage renal disease (ESRD) on chronic dialysis
  • Patients with a history of renal transplantation
  • Patients with advanced chronic kidney disease stage 5 (eGFR <15 mL/min/1.73 m²) not on dialysis
  • Patients with lower gastrointestinal bleeding
  • Patients with incomplete or missing essential renal function data
  • Patients discharged or deceased within 24 hours of hospital admission
  • Pregnant patients
  • Patients with acute kidney injury at presentation due to causes other than UGIB

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

队列和干预

团体/队列
干预/治疗
Patients with Acute Upper Gastrointestinal Bleeding
Adult patients (≥18 years) presenting with acute upper gastrointestinal bleeding (UGIB) and admitted to Sohag University Hospitals. Patients will be followed prospectively to assess the incidence of acute kidney injury (AKI) and its predictors.
其他：Observational assessment
No therapeutic intervention is applied. Patients are managed according to standard hospital care, and data are collected observationally.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Incidence of Acute Kidney Injury (AKI) According to KDIGO Criteria
大体时间：From hospital admission through hospital discharge, up to 30 days
The incidence of acute kidney injury (AKI) among patients presenting with acute upper gastrointestinal bleeding (UGIB), defined according to KDIGO criteria based on changes in serum creatinine and/or urine output during hospitalization.
From hospital admission through hospital discharge, up to 30 days

次要结果测量

结果测量
措施说明
大体时间
Percentage of Patients Developing AKI According to Bleeding Etiology
大体时间：Baseline (hospital admission) with AKI occurrence assessed through hospital discharge, up to 30 days
Comparison of AKI incidence between variceal and non-variceal UGIB patients.
Baseline (hospital admission) with AKI occurrence assessed through hospital discharge, up to 30 days
Change in Serum Creatinine Concentration
大体时间：Through hospital discharge, up to 30 days
Serum creatinine concentration (mg/dL) measured at admission and during hospitalization to assess changes in renal function.
Through hospital discharge, up to 30 days

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Sohag University

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年5月15日

初级完成 (估计的)

2027年1月15日

研究完成 (估计的)

2027年5月15日

研究注册日期

首次提交

2026年5月6日

首先提交符合 QC 标准的

2026年6月4日

首次发布 (实际的)

2026年6月9日

研究记录更新

最后更新发布 (实际的)

2026年6月9日

上次提交的符合 QC 标准的更新

2026年6月4日

最后验证

2026年5月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • SOHAG-UGIB-AKI-26

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

未定

IPD 计划说明

A decision regarding sharing individual participant data (IPD) has not yet been finalized. Any future data sharing will be considered in accordance with institutional policies and participant consent.

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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