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The Effect of Mindfulness in Inflammation Markers (MLR, NLR, PLR), Stress, Anxiety, and Depression Rate Among Survivors of Tidal Flooding in Sayung Demak

2026年8月27日 更新者：Natalia Dewi Wardani, MD

Tidal flood disasters in coastal areas cause chronic psychological stress due to economic, social, and residential disruption. Psychological stress is closely linked to systemic inflammatory responses-marked by elevated Monocyte-to-Lymphocyte Ratio (MLR), Neutrophil-to-Lymphocyte Ratio (NLR), and Platelet-to-Lymphocyte Ratio (PLR)-which are associated with depression and anxiety symptoms. Mindfulness interventions, particularly body scan techniques, have been shown to reduce psychological distress and modulate immune responses, but empirical evidence on coastal flood survivors in Indonesia remains limited.

This study aims to evaluate the effectiveness of a community-based mindfulness body scan intervention on inflammatory biomarkers (MLR, NLR, PLR) and psychological parameters (stress, depression, anxiety, trauma, sleep quality, and resilience) among tidal flood survivors in Sayung, Demak. Participants will undergo baseline blood work and psychometric assessments, receive an 8-day mindfulness body scan intervention, and complete post-intervention evaluations.

研究概览

地位

尚未招聘

条件

干预/治疗

详细说明

Background:

Coastal communities in Sayung District, Demak Regency, face recurrent tidal flooding (rob) that causes continuous environmental and economic pressure. From a psychoneuroimmunological perspective, chronic psychosocial stress triggers systemic low-grade inflammation. Biomarkers such as MLR, NLR, and PLR serve as accessible systemic inflammatory indices that correlate with mood disorders and stress severity. Mindfulness body scan training aims to improve interoceptive awareness, emotional regulation, and parasympathetic activity, thereby reducing stress reactivity and systemic inflammation.

Study Design and Objectives:

This is an interventional pre-post experimental study conducted at the Sayung 1 Public Health Center (Puskesmas Sayung 1), Demak. The study evaluates changes in systemic inflammatory markers and psychological parameters pre- and post-intervention.

Intervention:

Participants will participate in a structured mindfulness body scan program over an 8-day period. The body scan protocol guides participants to direct attention sequentially to various body regions without judgment to enhance somatic awareness and stress mitigation.

Assessments:

  1. Laboratory Testing: Complete blood counts to determine monocyte, neutrophil, platelet, and lymphocyte ratios (MLR, NLR, PLR) pre- and post-intervention.

  2. Psychometric Evaluations: Assessment of psychological symptoms using validated tools, including:

    • Beck Depression Inventory (BDI) & Patient Health Questionnaire-9 (PHQ-9)
    • Depression, Anxiety, and Stress Scale-21 (DASS-21)
    • Impact of Event Scale - Revised (IES-R) & PTSD Checklist-5 (PCL-5)
    • Pittsburgh Sleep Quality Index (PSQI)
    • Connor-Davidson Resilience Scale (CD-RISC)
    • Spiritual Wellbeing Scale (SWBS)
    • Fatigue Assessment Scale (FAS)
    • WHO Quality of Life (WHOQOL)
    • Perceived Social Performance (PSP)

Data Analysis:

Pre- and post-intervention data will be analyzed using paired statistical tests and multivariate regression to determine changes in inflammatory markers and psychological scores, as well as the correlation between systemic inflammation changes and psychological recovery.

研究类型

介入性

注册 (估计的)

70

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

  • 姓名：Natalia Dewi Wardani Dr. dr. Sp.KJ(K)
  • 电话号码：+6281325683134
  • 邮箱：anatdew@gmail.com

学习地点

  • 印度尼西亚
    • Central Java
      • Demak、Central Java、印度尼西亚
        • Puskesmas Sayung 1

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人

接受健康志愿者

是的

描述

Inclusion Criteria:

  • Adults aged 18 to 60 years.
  • Survivors of tidal flooding (bencana rob) residing in the Sayung coastal area for at least 6 months.
  • Minimum educational attainment of Primary School (Sekolah Dasar / SD).
  • Literate in Indonesian (able to read and write).
  • Willing to participate in and complete the 8-day mindfulness intervention program.
  • Physically independent and capable of completing self-administered questionnaires.

Exclusion Criteria:

  • Active psychotic disorders or severe mental illness.
  • Cognitive impairment that limits ability to complete assessments.
  • History of diagnosed autoimmune disorders, active allergies, or chronic inflammatory diseases.
  • Presence of acute infectious disease symptoms within the past 1 month.
  • Currently undergoing formal psychotherapy or other structured psychological interventions.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：治疗
  • 分配：不适用
  • 介入模型：单组作业
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
实验性的：Mindfulness Body Scan Group
Participants in this single arm receive an 8-day community-based mindfulness body scan training designed to evaluate its effects on systemic inflammatory markers (MLR, NLR, PLR) and psychological parameters.
行为的：Mindfulness Body Scan
A structured 8-day behavioral intervention consisting of guided mindfulness body scan practices. Participants are instructed to direct non-judgmental attention sequentially across different regions of the body to enhance somatic awareness, promote relaxation, and reduce psychological stress reactivity.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Change in Monocyte-to-Lymphocyte Ratio (MLR)
大体时间：Baseline and Day 8 (post-intervention)
Changes in MLR derived from routine complete blood count to evaluate systemic inflammation.
Baseline and Day 8 (post-intervention)
Change in Neutrophil-to-Lymphocyte Ratio (NLR)
大体时间：Baseline and Day 8 (post-intervention)
Changes in NLR derived from routine complete blood count to evaluate systemic inflammation
Baseline and Day 8 (post-intervention)
Change in Platelet-to-Lymphocyte Ratio (PLR)
大体时间：Baseline and Day 8 (post-intervention)
Changes in PLR derived from routine complete blood count to evaluate systemic inflammation.
Baseline and Day 8 (post-intervention)
Change in DASS-21 Score
大体时间：Baseline and Day 8 (post-intervention)
Evaluation of changes in psychological distress using the Depression, Anxiety, and Stress Scale-21 (DASS-21). Total score ranges from 0 to 63, where higher scores indicate higher levels of psychological distress.
Baseline and Day 8 (post-intervention)
Change in Beck Depression Inventory (BDI) Score
大体时间：Baseline and Day 8 (post-intervention)
Evaluation of changes in depressive symptoms using the BDI questionnaire. Total score ranges from 0 to 63, where higher scores indicate more severe depression.
Baseline and Day 8 (post-intervention)
Change in Patient Health Questionnaire-9 (PHQ-9) Score
大体时间：Baseline and Day 8 (post-intervention)
Evaluation of depression severity using the PHQ-9 scale. Total score ranges from 0 to 27, where higher scores indicate more severe depressive symptoms.
Baseline and Day 8 (post-intervention)

次要结果测量

结果测量
措施说明
大体时间
Change in Pittsburgh Sleep Quality Index (PSQI) Score
大体时间：Baseline and Day 8 (post-intervention)
Evaluation of sleep quality using the PSQI questionnaire. Total score ranges from 0 to 21, where higher scores indicate poorer sleep quality.
Baseline and Day 8 (post-intervention)
Change in Connor-Davidson Resilience Scale (CD-RISC) Score
大体时间：Baseline and Day 8 (post-intervention)
Evaluation of psychological resilience levels using the CD-RISC questionnaire. Total score ranges from 0 to 100, where higher scores indicate greater resilience.
Baseline and Day 8 (post-intervention)
Change in Impact of Event Scale-Revised (IES-R) Score
大体时间：Baseline and Day 8 (post-intervention)
Evaluation of post-traumatic stress distress related to the tidal flood disaster using the IES-R. Total score ranges from 0 to 88, where higher scores indicate greater post-traumatic distress.
Baseline and Day 8 (post-intervention)
Change in WHOQOL-BREF Score
大体时间：Baseline and Day 8 (post-intervention)
Evaluation of quality of life across physical, psychological, social, and environmental domains using the WHOQOL-BREF scale. Domain scores are transformed to a scale of 0 to 100, where higher scores indicate higher quality of life.
Baseline and Day 8 (post-intervention)

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Natalia Dewi Wardani, MD

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

  • Kabat-Zinn J. Full catastrophe living: using the wisdom of your body and mind to face stress, pain, and illness. New York: Dell Publishing; 2013.

有用的网址

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年9月1日

初级完成 (估计的)

2027年2月1日

研究完成 (估计的)

2027年4月1日

研究注册日期

首次提交

2026年8月27日

首先提交符合 QC 标准的

2026年8月27日

首次发布 (实际的)

2026年9月1日

研究记录更新

最后更新发布 (实际的)

2026年9月1日

上次提交的符合 QC 标准的更新

2026年8月27日

最后验证

2026年8月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • FK-UNDIP-MIND-02

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

不

IPD 计划说明

The data are not publicly available due to privacy or ethical restrictions. The dataset involves sensitive information about mental health, and sharing it publicly would compromise participant confidentiality as per the ethical approval obtained.

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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