PM2.5 Exposure, Obesity, and Cardiovascular Health
Investigating Interactions Between PM2.5 Exposure, Obesity, Cardiovascular Health and Dietary Antioxidant in Subjects With Obesity
Obesity and exposure to fine particulate matter (particles of aerodynamic diameter less than 2.5 µm, PM2.5) air pollution are established risk factors for cardiovascular (CV) morbidity and mortality. This proposed pilot project seeks to assess interactions between PM2.5 exposure, obesity, CV health, and dietary antioxidant in subjects with obesity.
研究概览
详细说明
This proposed intervention study will investigate (1) whether the use of portable air filtration systems (PAFS), by lowering PM2.5 exposures, will improve CV risk factors in subjects with obesity; and (2) whether antioxidant levels will modify the association between PM2.5 exposure and blood pressure. Our project will help validate the benefits of novel strategies to employ PAFS. Positive results would represent a key step in forming the evidence base required to promote more wide-scale PAFS use; in the long term, given their low cost and burden, PAFS use could be up-scaled to help protect diverse populations.
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习地点
-
-
Michigan
-
East Lansing、Michigan、美国、48824
- 招聘中
- Michigan State University
-
接触：
- Study coordinator
- 电话号码：517-884-4068
- 邮箱：klaverza@msu.edu
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- ≥21 years old
- diagnosis of hypertension (BP ≥140/90 mm Hg)
- obesity (BMI>30)
Exclusion Criteria:
- any CV event (myocardial infarction, stroke, heart failure) in the past 3 months
- unstable CV condition (class 3-4 angina or heart failure) or any medical condition that would place the subject at risk from participation or jeopardize study integrity (per investigators)
- expected overnight travel outside their home during the 9-week study period
- unable to comprehend/sign informed consent
- lung disease requiring oxygen
- cancer receiving active treatment or chemotherapy
- CPAP use for sleep apnea
- CV medication change in the prior month
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：双倍的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
假比较器：Arm 1
Participants are exposed to unfiltered air (sham) via air filtration systems in the bedroom and main living space of each residence. |
Subjects were exposed to high-efficiency filtered air. |
|
有源比较器：Arm 2
Participants were exposed to high-efficiency (HEPA) filtered air via air filtration systems in the bedroom and main living space of each residence. |
Subjects were exposed to high-efficiency filtered air. |
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Brachial blood pressure
大体时间：Daily for 28 days, between 8-10 AM, starting 24 hours after air filtration systems are placed
|
Daily for 28 days, between 8-10 AM, starting 24 hours after air filtration systems are placed
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
C-reactive protein
大体时间：Day 1 and Day 28 of each 4-week intervention period.
|
Blood samples for inflammatory marker (high-sensitivity C-reactive protein) |
Day 1 and Day 28 of each 4-week intervention period.
|
|
Carotenoid
大体时间：Day 1 and Day 28 of each 4-week intervention period.
|
non-invasive optical measurement of skin carotenoid levels |
Day 1 and Day 28 of each 4-week intervention period.
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- CH-MSU Alliance
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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