- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00005444
Hypertension in Families of African Origin
Study Overview
Status
Conditions
Detailed Description
BACKGROUND:
It has been known for many years that African Americans experience twofold higher rates of hypertension than do whites. The underlying biological mechanisms which lead to this differential are still not understood, however. Despite widespread speculation that persons of African descent are genetically susceptible to hypertension, few direct studies have been carried out. Rates of hypertension remain low in West Africa, and this study will provide a contrast between populations of similar genetic background in a low versus high risk environmental setting
DESIGN NARRATIVE:
A total of 240 families were identified from completed community surveys in Maywood, Illinois and Ibadan, Nigeria. Probands were ages 45-55 and equally divided between males and females. A minimum of five first-degree relatives were examined in each family to obtain information on the following variables: blood pressure (BP), obesity, urinary sodium and potassium, socioeconomic status and physical activity. In addition, plasma and DNA were collected and stored for future studies of relevant physiologic intermediate phenotypes and candidate genes for hypertension in the two contrasting populations. These data provided the basis for examining familial aggregation of blood pressure/hypertension and related CV risk factors. Three primary goals were addressed: 1) to determine whether the familial aggregation of blood pressure in Black populations was influenced by the overall distribution of environmental factors at the population level, by contrasting the distribution of familial correlations of blood pressure and the familial aggregation of hypertension, in Nigeria and the United States; to determine the significance of measured environmental correlates of blood pressure by comparing the magnitude of variance components for probands and relatives in each setting; and 3) to use path analysis to obtain estimates of genetic and cultural heritability of blood pressure, controlling for clustering environmental factors at the household level. Plasma and DNA samples collected in this study provided additional valuable resources for future molecular research.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Study Type
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Study Plan
How is the study designed?
Collaborators and Investigators
Investigators
- Charles Rotimi, Howard University
Publications and helpful links
General Publications
- Rotimi C, Luke A, Li Z, Compton J, Bowsher R, Cooper R. Heritability of plasma leptin in a population sample of African-American families. Genet Epidemiol. 1997;14(3):255-63. doi: 10.1002/(SICI)1098-2272(1997)14:33.0.CO;2-4.
- Rotimi C, Cooper R, Ogunbiyi O, Morrison L, Ladipo M, Tewksbury D, Ward R. Hypertension, serum angiotensinogen, and molecular variants of the angiotensinogen gene among Nigerians. Circulation. 1997 May 20;95(10):2348-50. doi: 10.1161/01.cir.95.10.2348.
- Colilla S, Rotimi C, Cooper R, Goldberg J, Cox N. Genetic inheritance of body mass index in African-American and African families. Genet Epidemiol. 2000 Apr;18(4):360-76. doi: 10.1002/(SICI)1098-2272(200004)18:43.0.CO;2-H.
- Luke A, Rotimi CN, Adeyemo AA, Durazo-Arvizu RA, Prewitt TE, Moragne-Kayser L, Harders R, Cooper RS. Comparability of resting energy expenditure in Nigerians and U.S. blacks. Obes Res. 2000 Aug;8(5):351-9. doi: 10.1038/oby.2000.42.
- Okosun IS, Liao Y, Rotimi CN, Prewitt TE, Cooper RS. Abdominal adiposity and clustering of multiple metabolic syndrome in White, Black and Hispanic americans. Ann Epidemiol. 2000 Jul;10(5):263-70. doi: 10.1016/s1047-2797(00)00045-4.
- Schork NJ, Chakravarti A, Thiel B, Fornage M, Jacob HJ, Cai R, Rotimi CN, Cooper RS, Weder AB. Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and African Americans. Am J Hypertens. 2000 Jun;13(6 Pt 1):693-8. doi: 10.1016/s0895-7061(00)00237-5.
- Rotimi CN, Cooper RS, Cao G, Ogunbiyi O, Ladipo M, Owoaje E, Ward R. Maximum-likelihood generalized heritability estimate for blood pressure in Nigerian families. Hypertension. 1999 Mar;33(3):874-8. doi: 10.1161/01.hyp.33.3.874.
- Rotimi CN, Comuzzie AG, Lowe WL, Luke A, Blangero J, Cooper RS. The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans. Diabetes. 1999 Mar;48(3):643-4. doi: 10.2337/diabetes.48.3.643. No abstract available.
- Cooper RS, Guo X, Rotimi CN, Luke A, Ward R, Adeyemo A, Danilov SM. Heritability of angiotensin-converting enzyme and angiotensinogen: A comparison of US blacks and Nigerians. Hypertension. 2000 May;35(5):1141-7. doi: 10.1161/01.hyp.35.5.1141.
Study record dates
Study Major Dates
Study Start
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 4373
- R29HL052075 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Heart Diseases
-
Baker Heart and Diabetes InstitutePrincess Alexandra Hospital, Brisbane, Australia; Royal Perth Hospital; Alice... and other collaboratorsRecruitingHeart Failure | Valve Heart DiseaseAustralia
-
Medical University of ViennaUnknownHeart Diseases | Heart Failure | Valvular Heart DiseaseAustria
-
Centre Chirurgical Marie LannelongueActive, not recruitingValvular Heart Disease | Valve Disease, Heart
-
Kathirvel SubramaniamUniversity of Maryland, Baltimore; CSL BehringRecruitingHeart Failure,Congestive | Heart Disease End StageUnited States
-
Abiomed Inc.RecruitingHeart Diseases | Acute Decompensated Heart Failure | Congestive Heart Failure | Acute Heart FailureUnited States
-
University of MichiganTerminatedDiastolic Heart Failure | Hypertensive Heart DiseaseUnited States
-
Wuerzburg University HospitalRecruitingHeart Failure | Chronic Heart Failure | Chronic Heart DiseaseGermany
-
Aristotle University Of ThessalonikiRecruitingCardiovascular Diseases | Heart Failure | Valvular Heart Disease | Biochemical DysfunctionGreece
-
Yonsei UniversityCompletedMitral Valvular Heart Disease
-
Wake Forest UniversityNational Institute on Aging (NIA)CompletedHeart Failure, Congestive | Diastolic Heart FailureUnited States