- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00070889
Brain Cell Injury in Patients With A First Episode of Psychosis
Oxidative Cell Injury: First Episode Psychotic Patients
Study Overview
Status
Conditions
Detailed Description
Preliminary research indicated that impaired antioxidant defense and increased lipid peroxidation is associated with brain changes during the onset of psychosis. Oxidative cell injury may contribute to poor outcomes in some patients. This study will define the extent and nature of oxidative cell injury that is associated with psychopathology at the onset of psychosis.
Participants in this study will be patients at the D. D. Eisenhower Army Medical Center who are experiencing a psychotic episode for the first time. Patients will be compared with 40 healthy volunteers (control group) matched with patients for age, gender, education, ethnic background, and occupational status. Patients and volunteers will have blood tests to determine the level of oxidative cell injury. Tests will be performed at onset of psychosis, and after 6 and 12 weeks of neuroleptic drug treatment. Medical histories and MRI scans will be used to examine the relationship of the laboratory tests to the clinical presentation.
Study Type
Enrollment
Contacts and Locations
Study Locations
-
-
Georgia
-
Augusta, Georgia, United States, 30912
- Medical College of Georgia
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria
- Patients must meet clinical diagnostic criteria for psychosis
- Healthy (control) volunteers must not have any family history of mental illness
Study Plan
How is the study designed?
Design Details
Collaborators and Investigators
Investigators
- Principal Investigator: Sahebrao P. Mahadik, PhD, Augusta University
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- R01AT000147-01 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Psychoses
-
Heinrich-Heine University, DuesseldorfGerman Federal Ministry of Education and Research; University of Cologne; RWTH... and other collaboratorsCompletedSchizophrenia | PsychosesGermany
-
University Hospital, AkershusCompletedAffective Disorder | Psychoses
-
University Hospital, Strasbourg, FranceRecruiting
-
Hasan Kalyoncu UniversityNot yet recruiting
-
Heinrich-Heine University, DuesseldorfGerman Federal Ministry of Education and Research; University of Cologne; RWTH... and other collaboratorsCompletedSchizophrenia | PsychosesGermany
-
Centre for Addiction and Mental HealthCanadian Institutes of Health Research (CIHR); Institute for Clinical Evaluative...RecruitingSchizophrenia | Schizophrenia Spectrum and Other Psychotic Disorders | Schizoaffective Disorder | Bipolar Disorder | Psychosis | Schizophreniform Disorders | Substance Induced Psychoses | Psychotic Episode | First Episode Psychosis | Psychoses, Affective | Depressive PsychosisCanada
-
Ontario Mental Health FoundationUnknown
-
Menzies School of Health ResearchNational Health and Medical Research Council, Australia; Northern Territory... and other collaboratorsUnknownDepression | Schizophrenia | Schizoaffective Disorder | Bipolar Disorder | Psychoses, Substance InducedAustralia
-
China Medical University HospitalNational Science Council, Taiwan; National Health Research Institutes, TaiwanCompletedPsychotic Disorders | Schizophrenic Disorders | Schizophrenias | PsychosesTaiwan
-
Beth Israel Deaconess Medical CenterCenter de Neurosciences Psychiatrique, Lausanne, SwitzerlandCompletedSchizophrenic PsychosesUnited States