- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00172835
Use of Procalcitonin in the Diagnosis of Pleural Effusion
September 12, 2005 updated by: National Taiwan University Hospital
Evaluation of Procalcitonin as a Diagnostic Tool for Patients With Pleural Effusion
Among several markers of inflammation and sepsis, procalcitonin (PCT) markers is being studied to investigate their accuracy for the diagnosis of bacterial infections.
PCT is the prehormone of calcitonin, which is normally secreted by the C cells of the thyroid in response to hypercalcemia; under these normal conditions, negligible serumPCT concentrations are detected.
The mechanism proposed for PCT production after inflammation and its role are still not completely known.
It is believed that PCT is produced by the liver and peripheral blood mononuclear cells, modulated by lipopolysaccharides and sepsis-related cytokines.
It binds to polysaccharides in pathogens, activating the classical complement pathway.
The reported diagnostic accuracy of PCT for the diagnosis of bacterial infections has varied across studies.
Study Overview
Status
Unknown
Conditions
Study Type
Observational
Enrollment
100
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Po-Ren Hsueh, MD
- Phone Number: 886-2-2356-5363
- Email: prhsueh@ntumc.org
Study Locations
-
-
-
Taipei, Taiwan
- Recruiting
- National Taiwan University Hospital
-
Contact:
- Po-Ren Hsueh, MD
- Phone Number: 776-2-23565363
- Email: prhsueh@ntumc.org
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Clinical diagnosis of pleural effusion
- Pleural effusion proved by chest sonography
Exclusion Criteria:
- Conditions for which thoracentesis are contraindicated
- Pregnancy
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Po-Ren Hsueh, MD, Department of Laboratory Medicine, National Taiwan University Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
March 1, 2005
Study Registration Dates
First Submitted
September 12, 2005
First Submitted That Met QC Criteria
September 12, 2005
First Posted (Estimate)
September 15, 2005
Study Record Updates
Last Update Posted (Estimate)
September 15, 2005
Last Update Submitted That Met QC Criteria
September 12, 2005
Last Verified
March 1, 2005
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 9461700208
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Pleural Effusion
-
Naestved HospitalTerminatedMalignant Pleural Effusion | Exudative Pleural EffusionDenmark
-
Oregon Health and Science UniversityThe Gerber FoundationCompletedChylous Pleural Effusion Following Cardiothoracic SurgeryUnited States
-
Sheng HuWuhan Binhui Biotechnology Co., Ltd.RecruitingMalignant Pleural Effusion | Malignant Peritoneal EffusionChina
-
M.D. Anderson Cancer CenterNational Cancer Institute (NCI)RecruitingPleural NeoplasmUnited States
-
Clover Biopharmaceuticals AUS Pty LtdCompletedMalignant Pleural EffusionsAustralia
-
JemincareZhejiang Hangyu Pharmaceutical Co., LtdRecruitingMalignant Pleural EffusionChina
-
National University of Ireland, Galway, IrelandRecruitingMalignant Pleural EffusionIreland
-
Jiangsu Simcere Pharmaceutical Co., Ltd.Not yet recruiting
-
Washington University School of MedicineMerit Medical Systems, Inc.CompletedMalignant Pleural EffusionUnited States
-
Duke UniversityTerminated