- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00226707
Pimecrolimus Cream 1% in Patients (18 Years of Age and Over) With Mild to Moderate Chronic Hand Dermatitis
February 13, 2008 updated by: Novartis
A 6-Week Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel Group Study to Investigate the Efficacy and Safety of Pimecrolimus Cream 1% in Patients With Mild-to-Moderate Chronic Hand Dermatitis Followed by a 6-Week Open-Label Phase to Assess the Safety of Pimecrolimus Cream 1%
Topical steroids are standard of care for Chronic Hand Dermatitis, but long-term use is associated with adverse effects.
This study will assess the efficacy and safety of pimecrolimus cream 1% in patients with mild-to-moderate chronic hand dermatitis.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment
652
Phase
- Phase 3
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Description
Inclusion Criteria:
- - Patients who are outpatients at baseline (Day 1)
- Patients must be 18 years of age or above
- Patients must have chronic hand dermatitis based upon clinical diagnosis with mild to moderate dermatitis of the target hand at baseline, as defined by an Investigator's Global Assessment score of 2 (mild) or 3 (moderate).
- Patients must have been informed of the study procedures and medication and have given their written informed consent
Exclusion Criteria:
- - Women who are pregnant or who are breast-feeding.
- Patients who have received systemic corticosteroids (i.e., oral, intravenous, intra-articular, rectal, intramuscular) within one month prior to first application of study medication.
- Patients who have received phototherapy (e.g., UVB, PUVA) or systemic therapy (e.g., immunosuppressants, cytostatics) known or suspected to have an effect on hand dermatitis within at least one month prior to first application of study medication.
- Patients who have received pimecrolimus cream 1% or tacrolimus ointment 0.1% or 0.03% within 14 days prior to first application of study medication.
- Patients who were treated with topical therapy (e.g., tar, topical corticosteroids, Burrows solution soaks) known or suspected to have an effect on hand dermatitis within 7 days prior to first application of trial medication.
Other protocol-defined inclusion/exclusion criteria may apply.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Investigators Global Assessment (IGA) of the target hand at day 43 or at time of early discontinuation.
|
Secondary Outcome Measures
Outcome Measure |
---|
IGA of the non-target hand
|
Itching/burning assessment for the target and non-target hand
|
Non-key signs of hand dermatitis (vesiculation, oozing/crusts, edema/population, lichenification) at each study visit
|
Work productivity and activity impairment questionnaire
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
July 1, 2004
Study Completion (Actual)
March 1, 2005
Study Registration Dates
First Submitted
September 26, 2005
First Submitted That Met QC Criteria
September 26, 2005
First Posted (Estimate)
September 27, 2005
Study Record Updates
Last Update Posted (Estimate)
February 15, 2008
Last Update Submitted That Met QC Criteria
February 13, 2008
Last Verified
February 1, 2008
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Skin Diseases
- Dermatitis
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Peripheral Nervous System Agents
- Enzyme Inhibitors
- Analgesics
- Sensory System Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Antirheumatic Agents
- Immunosuppressive Agents
- Immunologic Factors
- Dermatologic Agents
- Calcineurin Inhibitors
- Pimecrolimus
Other Study ID Numbers
- CASM981M2301
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Chronic Hand Dermatitis
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University Hospital, Gentofte, CopenhagenTrygFonden, DenmarkCompletedChronic Hand Dermatitis | Chronic Hand EczemaDenmark
-
HenKan Pharmaceutical Co., Ltd.Completed
-
Innovaderm Research Inc.Tribute PharmaceuticalsCompletedChronic Hand DermatitisCanada
-
George Washington UniversityCelgene CorporationWithdrawnChronic Hand DermatitisUnited States
-
University of RochesterIncyte CorporationActive, not recruiting
-
Asana BioSciencesCompletedChronic Hand DermatitisUnited States, Canada
-
University Hospital, ToulouseRecruiting
-
LEO PharmaRecruiting
-
The Center for Clinical and Cosmetic ResearchAfecta PharmaceuticalsCompletedHand DermatitisUnited States
-
National Jewish HealthCompletedHand DermatitisUnited States
Clinical Trials on Pimecrolimus Cream 1%
-
Actavis Inc.CompletedAtopic DermatitisUnited States
-
Glenmark Pharmaceuticals Ltd. IndiaCompletedAtopic DermatitisUnited States
-
Mylan Inc.DPT Laboratories, Ltd.CompletedAtopic DermatitisUnited States, Dominican Republic, Honduras
-
Technische Universität DresdenCompleted
-
Par Pharmaceutical, Inc.Completed
-
Technische Universität DresdenCompleted
-
University of UtahNovartisCompleted
-
Children's Hospital of MichiganNovartis PharmaceuticalsTerminated
-
GlaxoSmithKlineCompletedDermatitis, AtopicUnited States, Canada, Japan
-
Dermavant Sciences GmbHCompletedAtopic DermatitisUnited States, Canada