Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen (PRECISION)

March 1, 2021 updated by: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

A Randomized, Double Blind, Parallel-group Study Of Cardiovascular Safety In Osteoarthritis Or Rheumatoid Arthritis Patients With Or At High Risk For Cardiovascular Disease Comparing Celecoxib With Naproxen And Ibuprofen

To answer the question of overall benefit: risk of celecoxib when compared to two most commonly prescribe traditional (non-selective) nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of arthritis pain. For this purpose, patients with osteoarthritis or rheumatoid arthritis with or at risk of developing cardiovascular disease will be recruited. The cardiovascular, gastrointestinal and renal safety and symptomatic benefit in each treatment group will be assessed accordingly.

Study Overview

Status

Completed

Conditions

Arthritis, Rheumatoid

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

24081

Phase

Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Australia
- New South Wales
  - Broadmeadow, New South Wales, Australia, 2292
    - Hunter Clinical Research
- Queensland
  - Auchenflower, Queensland, Australia, 4066
    - Wesley Medical Centre
  - Caboolture, Queensland, Australia, 4510
    - Australian Clinical Research Organisation
  - Cairns, Queensland, Australia, 4870
    - Rheumatology department
  - Kippa Ring, Queensland, Australia, 4021
    - AusTrials Pty Ltd
  - Milton, Queensland, Australia, 4064
    - Core Research Group
  - Sherwood, Queensland, Australia, 4075
    - AusTrials Pty Ltd
- Victoria
  - Clayton, Victoria, Australia, 3168
    - Monash Medical Centre, Department of Rheumatology
  - Heidelberg West, Victoria, Australia, 3081
    - Rheumatology department
  - Malvern East, Victoria, Australia, 3145
    - Emeritus Research
- Western Australia
  - Shenton Park, Western Australia, Australia, 6008
    - The Goatcher Clinical Research Unit
  - Victoria Park, Western Australia, Australia, 6979
    - The Colin Bayliss Research and Teaching Unit
Brazil
- - Goiania-GO, Brazil, 74110-020
    - Hospital Sao Salvador - Medicos Reunidos Ltda.
  - Marilia/SP, Brazil, 17519-000
    - Ambulatorio de Especialidades Mario Covas
  - Porto Alegre, RS, Brazil, 91350-200
    - Hospital Nossa Senhora da Conceicao
  - Recife - Pernambuco, Brazil, 52679-420
    - Hospital das clínicas da UFPE
  - Rio de Janeiro, Brazil, 20221-903
    - Hospital dos Servidores do Estado do Rio de Janeiro
  - Santo Andre, Brazil, 09060-650
    - Faculdade de Medicina do ABC
- AL
  - Maceio, AL, Brazil, 57021-500
    - CLINCOR - Clinica de Exames Cardiologicos e Ecografia S/C Ltda
  - Maceio, AL, Brazil, 57052-580
    - Hospital do Coracao de Alagoas
- GO
  - Goiania, GO, Brazil, 74110-120
    - CIP - Centro Internacional de Pesquisas
  - Goiania, GO, Brazil, 74223-130
    - Via Medica - Centro Clinico
- MG
  - Juiz de Fora, MG, Brazil, 36010-570
    - CMiP - Centro Mineiro de Pesquisa
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30150-260
    - Hopsital das Clinicas da Universidade Federal de Minas Gerais
- PR
  - Campina Grande do Sul, PR, Brazil, 83430-000
    - Hospital e Maternidade Angelina Caron, Sala Pesquisa Clinica
  - Curitiba, PR, Brazil, 80030-220
    - CEPEME-CERHFAC Centro de Estudos e Pesquisas Medicas
  - Curitiba, PR, Brazil, 80060-240
    - Centro de Estudos do Hospital de Clínicas da UFPR
- RJ
  - Rio de Janeiro, RJ, Brazil, 21941-913
    - Hospital Universitário Clementino Fraga Filho - UFRJ
  - Rio de Janeiro, RJ, Brazil, 22271-100
    - CCBR Brasil Centro de Pesquisas e Analises Clinicas Ltda
  - Rio de Janeiro, RJ, Brazil, 22411-001
    - Hospital Ipanema Plus
  - Rio de Janeiro, RJ, Brazil, 22649-900
    - Clinica de Reumatologia do Centro Médico BarraShopping
- RS
  - Porto Alegre, RS, Brazil, 90035-903
    - Centro de Pesquisa Clinica
  - Porto Alegre, RS, Brazil, 90560-030
    - Associação Hospitalar Moinhos de Vento (AHMV) / CMIC
  - Porto Alegre, RS, Brazil, 90610-000
    - Hospital São Lucas - Pontificia
- SAO Paulo
  - Campinas, SAO Paulo, Brazil, 13059-740
    - Hospital e Maternidade Celso Pierro - PUC Campinas
- SE
  - Aracaju, SE, Brazil, 49015-400
    - Centro de Ensino e Pesquisa Hospital Sao Lucas
- SP
  - Campinas, SP, Brazil, 13059-740
    - PUC Campinas
  - Campinas, SP, Brazil, 13083-888
    - Hospital das Clínicas da Unicamp
  - Marilia, SP, Brazil, 17519-030
    - Hospital das Clinicas da Faculdade de Medicina de Marilia
  - Sao Jose do Rio Preto, SP, Brazil, 15090-000
    - Hospital de Base - Fundacao Faculdade Regional de Medicina de São José do Rio Preto
  - Sao Paulo, SP, Brazil, 01323-903
    - Hospital Alemao Oswaldo Cruz
  - Sao Paulo, SP, Brazil, 04039-030
    - Setor de Lip., Arterosc. e BioVasc. - Disc. de Cardiologia
  - Sao Paulo, SP, Brazil, 04266-010
    - CEPIC - Centro Paulista de Investigação Clínica
  - Sao Paulo, SP, Brazil, 05437-010
    - IMA Brasil - Instituto de Medicina Avançada
  - São Paulo, SP, Brazil, 01244-030
    - CPClin - Centro de Pesquisas Clínicas
Canada
- - Quebec, Canada, G1V 4G5
    - Institut Universitaire de cardiologie et de pneumologie de Quebec
  - Quebec, Canada, G1G 3Y8
    - Recherche Clinique Sigma, Inc.
- Alberta
  - Calgary, Alberta, Canada, T2X 3X7
    - South Calgary Medical Clinic - Sunpark Professional Center
  - Edmonton, Alberta, Canada, T5K 2A2
    - Allin Clinic
  - Edmonton, Alberta, Canada, T6K 4C1
    - Dr. MPJ Senaratne Professional Corporation
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 3G8
    - Medical Arts Health Research Group
  - Penticton, British Columbia, Canada, V2A 5C8
    - The Medical Arts Health Research Group
  - Surrey, British Columbia, Canada, V3S 2N6
    - Ocean West Research Clinic Inc.
  - Vancouver, British Columbia, Canada, V5Z 4E1
    - Prohealth Clinical Research Inc.
  - Victoria, British Columbia, Canada, V8P 5P6
    - Office of Dr. Milton F. Baker
  - West Vancouver, British Columbia, Canada, V7T 2Z3
    - The Medical Arts Health Research Group
- Manitoba
  - Winnipeg, Manitoba, Canada, R3A 1M3
    - Manitoba Clinic
  - Winnipeg, Manitoba, Canada, R2V 4W3
    - Rivergrove Medical Clinic
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - G.A. Research Associates Ltd/Ltee
  - Quispamis, New Brunswick, Canada, E2E 4J8
    - Eric N. Grant Professional Corporation
  - Saint John, New Brunswick, Canada, E2K 2T8
    - Office of Dr. Brian N. Craig
- Newfoundland and Labrador
  - Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
    - Commonwealth Medical Clinic
  - Paradise, Newfoundland and Labrador, Canada, A1L 1C6
    - Paradise Medical Clinic
  - St. John's, Newfoundland and Labrador, Canada, A1A 3R5
    - White Hills Medical Clinic
  - St. John's, Newfoundland and Labrador, Canada, A1A 5E8
    - Nexus Clinic Research
  - St. John's, Newfoundland and Labrador, Canada, A1C 2H5
    - The Clinical Trials Centre
  - St. John's, Newfoundland and Labrador, Canada, A1E 2E2
    - Topsail Road Medical Clinic
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3K 0A4
    - MSHJ Research Associates, Inc.
  - Truro, Nova Scotia, Canada, B2N 1L2
    - Colchester Research Group
- Ontario
  - Brampton, Ontario, Canada, L6R 3A5
    - Office of Dr. Rohit Nagpal
  - Brampton, Ontario, Canada, L6T 3J1
    - Aggarwal and Associates Ltd.
  - Burlington, Ontario, Canada, L7M 4Y1
    - Aviva Clinical Trial Group Inc.
  - Corunna, Ontario, Canada, N0N 1G0
    - Corunna Medical Research Center
  - Fort Erie, Ontario, Canada, L2A 1Z3
    - C & L Research
  - Hamilton, Ontario, Canada, L8N 1Y2
    - Office of Dr. Jonathan D. Adachi
  - Kitchener, Ontario, Canada, N2E 4H9
    - Office of Dr. John Mutrie
  - Kitchener, Ontario, Canada, N2M 5N6
    - KW Musculoskeletal Research Inc.
  - London, Ontario, Canada, N5W 3C6
    - East London Medical Centre
  - London, Ontario, Canada, N5W 6A2
    - London East Medical Centre
  - London, Ontario, Canada, N5Y 5K7
    - Office of Dr. Gordon Schacter
  - London, Ontario, Canada, N6A 3H5
    - Office of Dr. William Blake Bowler
  - London, Ontario, Canada, N6A 5G6
    - Office of Dr. Robert G. Luton
  - Mississauga, Ontario, Canada, L4T 4J2
    - Malton Medical Centre
  - Newmarket, Ontario, Canada, L3Y 3R7
    - The Arthritis Program Research Group Inc.
  - Newmarket, Ontario, Canada, L3Y 5G8
    - SKDS Research Inc.
  - Niagara Falls, Ontario, Canada, L2E 7H1
    - Office of Dr. Azim M. Velji
  - Ottawa, Ontario, Canada, K1G 0Z3
    - AIM Health Group Trainyards Health and Wellness Centre
  - Sarnia, Ontario, Canada, N7T 4X3
    - London Road Diagnostic Clinic & Medical Center
  - Sarnia, Ontario, Canada, N7T 4X3
    - London Road Diagnostic Clinic & Medical Centre
  - Sudbury, Ontario, Canada, P3C 5K7
    - Office of Dr. Swaran K. Syan
  - Toronto, Ontario, Canada, M9W 4L6
    - Manna Research
  - Toronto, Ontario, Canada, M3M 3E5
    - Keele Medical Place
  - Toronto, Ontario, Canada, M4S 1Y2
    - Prime Health Clinical Research
  - Toronto, Ontario, Canada, M6A 3B5
    - Office of Dr. Ira Bernstein
  - Toronto, Ontario, Canada, M8V 3X8
    - Office of Dr. Subodh Kanani
  - Windsor, Ontario, Canada, N8X 5A6
    - Clinical Research and Arthritis Centre
  - Windsor, Ontario, Canada, N8W 1E6
    - North Walkerville Orthopaedic Associates
  - Windsor, Ontario, Canada, N8W 1E6
    - Research Office
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 5H6
    - Centre De Sante Et De Services Sociaux De Chicoutimi
  - Chicoutimi, Quebec, Canada, G7H 7P2
    - ECOGENE-21 / Centre de sante et de services sociaux de Chicoutimi
  - Cowansville, Quebec, Canada, J2K 2X9
    - Clinique de Medicine Familiale de Cowansville
  - L'Ancienne-Lorette, Quebec, Canada, G2E 2X1
    - Centre de recherche clinique Adapra Inc.
  - Montreal, Quebec, Canada, H1L 2N9
    - Centre de Recherche Hochelaga/ Clinique Medicale Hochelaga
  - Montreal, Quebec, Canada, H3N 1S4
    - Recherche Medicale Appliquee Informatics (AMIR) Inc.
  - Pointe-Claire, Quebec, Canada, H9R 4S3
    - Kells Medical Research Group, Inc.
  - Quebec City, Quebec, Canada, G1H 7L3
    - Le Manoir de l'Atrium
  - Rosemere, Quebec, Canada, J7A 1K7
    - Clinique Services Sante Rosemere
  - Saint-Marc-des-Carrieres, Quebec, Canada, G0A 4B0
    - Centre Medical des Carrieres
  - St-Jerome, Quebec, Canada, J7Z 5T3
    - St-Jerome Medical Research Inc.
  - Trois-Rivieres, Quebec, Canada, G8Z 1Y2
    - Centre de Recherche Musculo-Squelettique
  - Westmount, Quebec, Canada, H3Z 2M6
    - Cardiology and Research
- Saskatchewan
  - Saskatoon, Saskatchewan, Canada, S7L 0Y7
    - Downtown Medical Specialists
Colombia
- - Cali, Colombia, 760032
    - Fundacion Valle del Lili
- Antioquia
  - Medellin, Antioquia, Colombia
    - Reumalab S.A.S.
  - Medellin, Antioquia, Colombia, 050034
    - Hospital Pablo Tobon Uribe - Unidad de Investigaciones
  - Medellin, Antioquia, Colombia
    - IPS Rodrigo Botero S.A.S.
- Cundinamarca
  - Bogota, Cundinamarca, Colombia
    - Fundacion Cardioinfantil
  - Bogota, Cundinamarca, Colombia
    - Clinica Colsanitas Sa
- Santander
  - Floridablanca, Santander, Colombia
    - Fundacion cardiovascular de Colombia
Costa Rica
- - Alajuela, Costa Rica
    - Centro Medico San Rafael
  - Cartago, Costa Rica, 30101
    - Centro de Reumatologia y Osteoporosis
  - Cartago, Costa Rica
    - Clínica Garzona
  - Heredia, Costa Rica
    - Clinica de Especialidades Medicas Drs. Saenz Castro
  - Heredia, Costa Rica
    - Clínica Monte Sión
  - Heredia, Costa Rica
    - Clínica San Antonio
  - San Jose, Costa Rica
    - Hospital Clínica Biblica
  - San Jose, Costa Rica
    - Centro Medico San Jose
  - San Jose, Costa Rica
    - Edificio Panda
  - San Jose, Costa Rica
    - Oficina Privada
- Cartago
  - La Union De Tres Rios, Cartago, Costa Rica, 30303
    - Clínica Vía San Juan
- San Jose
  - Desamparados Centro, San Jose, Costa Rica, 0000
    - Clínica San Agustín
  - Escazu, San Jose, Costa Rica
    - Hospital CIMA San Jose
  - Goicoechea, San Jose, Costa Rica
    - Hospital Hotel La Catolica
- San José
  - Moravia, San José, Costa Rica, 0000
    - Consultorio Privado Dr. Alberto Lainez Ventosilla
Hong Kong
- - Pokfulam, Hong Kong
    - Department of Medicine, Queen Mary Hospital
  - Sheung Shui, NT, Hong Kong
    - Department of Medicine, North District Hospital
- NEW Territories
  - Shatin, NEW Territories, Hong Kong
    - Prince of Wales Hospital
- NT
  - New Territories, NT, Hong Kong
    - Centre for Assessment and Treatment of Rheumatic Diseases, Department of Medicine and Geriatrics
Mexico
- - Mexico City, Mexico, 03300
    - Clinicos Asociados Bocm, S.C.
- BAJA California
  - Tijuana, BAJA California, Mexico, 22010
    - Centro de Investigacion del Noroeste SC
- D.f.
  - Mexico, D.f., Mexico, 06100
    - Comite Mexicano para la Prevencion de la Osteoporosis, A.C.
  - Mexico, D.f., Mexico, 06700
    - Instituto Mexicano de Investigación Clínica, S.A. de C.V
- DF
  - Mexico, DF, Mexico, 14050
    - CIF-BIOTEC, Medica Sur
- Estado DE Mexico
  - Metepec, Estado DE Mexico, Mexico, 52140
    - Centro Medico Toluca
- Guanajuato
  - Leon, Guanajuato, Mexico, 37520
    - Hospital Regional ISSSTE
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44690
    - Centro de Estudios de Investigacion Basica y Clinica SC.
  - Guadalajara, Jalisco, Mexico, 44160
    - Instituto Jalisciense de Investigación Clínica Sa de Cv
- Michoacan
  - Morelia, Michoacan, Mexico, 58000
    - Unidad de Investigacion Dr. Mario Alvizouri Muñoz Ac Del Hospital General Dr. Miguel Silva
- SLP
  - San Luis Potosi, SLP, Mexico, 78240
    - Hospital Central "Dr. Ignacio Morones Prieto" Unidad Regional de Reumatologia y Osteoporosis
Panama
- - Panama City, Panama
    - Centro de Investigacion Marbella
Peru
- - Lima, Peru, 11
    - Clinica San Felipe
  - Lima, Peru, L29
    - Centro de Investigaciones Medical
  - Lima, Peru, Lima 36
    - Clinica San Juan Bautista
- Lima
  - San Isidro, Lima, Peru, L 27
    - IPC - Centro de Salud Integral S.A.
  - Santiago de Surco, Lima, Peru, 00033
    - Centro Empresarial - Altavista Polo 4
  - Santiago de Surco, Lima, Peru, 00033
    - Instituto de Ginecología y Reproducción & Cirugía Mínimamente Invasiva
Philippines
- - Cebu City, Philippines, 6000
    - Chong Hua Hospital
  - Davao City, Philippines, 8000
    - Southern Philippines Medical Center
  - Manila, Philippines, 1003
    - Jose R. Reyes Memorial Medical Center
  - Manila, Philippines, 1014
    - Chinese General Hospital and Medical Center
  - Manila, Philippines, 1015
    - Hospital Research Unit, University of Santo Tomas Hospital
  - Quezon City, Philippines, 1102
    - St. Luke's Medical Center
- Batangas
  - Lipa City, Batangas, Philippines, 4217
    - Mary Mediatrix Medical Center
- Cavite
  - Dasmarinas, Cavite, Philippines, 4114
    - De La Salle Health Sciences Institute
Taiwan
- - Chia-Yi County, Taiwan, 62247
    - Buddhist Tzu Chi Dailin General Hospital
  - Kaohsiung, Taiwan, 807
    - Chung-Ho Memorial Hospital, Kaoshiung Medical University Hospital
  - Taichung, Taiwan, 40705
    - Taichung Veterans General Hospital
  - Taichung, Taiwan, 402
    - Chung Shan Medical University Hospital
  - Taipei, Taiwan, 112
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 10018
    - National Taiwan University Hospital
  - Taipei City, Taiwan, 100
    - Tri-Service General Hospital
- Kaohsiung County
  - Nio Sung Township, Kaohsiung County, Taiwan, 833
    - Chang Gung Memorial Hospital-Kaohsiung branch, Section of Allergy, Immunology
- Taipei CITY
  - Neihu District, Taipei CITY, Taiwan, 114
    - Tri-Service General Hospital
- Taoyuan County
  - Gueishan Township, Taoyuan County, Taiwan, 333
    - Chang Gung Medical Foundation-Linkou Branch
- Yung Kang
  - Tainan, Yung Kang, Taiwan, 71004
    - Chi-Mei Medical Center
Ukraine
- - Chernivtsi, Ukraine, 58022
    - Municipal Medical Institution "City Clinical Hospital #3", Department of Rheumatology
  - Dnipropetrovsk, Ukraine, 49005
    - MI Dnipropetrovsk Regional Clinical Hospital named after I.I Mechnikov
  - Dnipropetrovsk, Ukraine, 49005
    - State Institution "Dnipropetrovsk Medical Academy of MOH, Ukraine
  - Donetsk, Ukraine, 83001
    - Rheumatology Department, MMI "City Clinical Hospital #5", DNMU n.a. M.Gorkyy,
  - Donetsk, Ukraine, 83003
    - Donetsk National Med University, Chair of Propaedeutics and Internal Medicine
  - Kharkiv, Ukraine, 61002
    - Municipal Establishment of Health Care
  - Kharkiv, Ukraine, 61178
    - City Clinical Hospital # 8, Dept of Cardiology and Functional Diagnostics
  - Kyiv, Ukraine, 02091
    - City Clinical Hospital #1
  - Kyiv, Ukraine, 03680
    - National Scientific Center "The Strazhesko Institute of Cardiology"
  - Kyiv, Ukraine, 04053
    - State Institution "Republican clinical hospital of MOH of Ukraine"
  - Kyiv, Ukraine, 04107
    - Family Medicine Department of NMAPE named after PL Shupyk,
  - Lutsk, Ukraine, 43024
    - Lutsk City Clinical Hospital
  - Lviv, Ukraine, 79013
    - Municipal City Clinical Hospital #5
  - Odesa, Ukraine, 65009
    - Center of Reconstructive and Regenerative Medicine (University clinic) of
  - Ternopil, Ukraine, 46010
    - Treatment-and-Diagnostic Center LLC "Desna" Ltd
  - Zaporizhzhia, Ukraine, 69118
    - Municipal enterprise " City Hospital # 7",
  - Zaporizhzhya, Ukraine, 69065
    - Municipal Institution "Zaporizhzhya City Multiple Discipline Clinical Hospital #9"
  - Zhytomyr, Ukraine, 10003
    - Zhytomyr Regional Clinical Hospital n.a. O.F. Gerbachevs'kyy/ Rheumatology Center
- Crimea
  - Simferopol, Crimea, Ukraine, 95017
    - CRI "Clinical Territorial Medical Association "University Clinic",
United States
- Alabama
  - Alabaster, Alabama, United States, 35007
    - Carol M. Johnson MD, LLC
  - Bessemer, Alabama, United States, 35022
    - Orthopaedics West
  - Birmingham, Alabama, United States, 35235
    - Alabama Clinical Therapeutics, LLC
  - Birmingham, Alabama, United States, 35216
    - Achieve Clinical Research, LLC
  - Birmingham, Alabama, United States, 35209
    - Central Alabama Research
  - Birmingham, Alabama, United States, 35211
    - Simon Williamson Clinic/Clinical Research Advantage, Inc.
  - Birmingham, Alabama, United States, 35242
    - Cahaba Research Inc.
  - Haleyville, Alabama, United States, 35565
    - Winston Technology Inc.
  - Hoover, Alabama, United States, 35216
    - Clinical Research Consultants, Inc
  - Huntsville, Alabama, United States, 35801
    - Rheumatology Associates of North Alabama, PC
  - Huntsville, Alabama, United States, 35801
    - Medical Affiliated Research Center, Incorporated
  - Montgomery, Alabama, United States, 36111
    - Montgomery Rheumatology Associates
  - Pelham, Alabama, United States, 35124
    - James P. Beretta, PC
  - Pell City, Alabama, United States, 35128
    - Alabama Clinical Research Associates
  - Pell City, Alabama, United States, 35215
    - Pell City Internal and Family Medicine
  - Scottsboro, Alabama, United States, 35768
    - Scottsboro Quick Care Clinic
  - Tuscaloosa, Alabama, United States, 35406
    - Clinic for Rheumatic Diseases
  - Tuscumbia, Alabama, United States, 35674
    - Terence T. Hart , MD
- Arizona
  - Chandler, Arizona, United States, 85224
    - Clinical Research Advantage Inc./ Warner Family Practice, PC
  - Gilbert, Arizona, United States, 85234
    - ArthroCare, Arthritis Care & Research P.C.
  - Glendale, Arizona, United States, 85306
    - Arizona Center For Clinical Research
  - Glendale, Arizona, United States, 85306-4652
    - Clinical Research Advantage Inc., /Thunderbird Internal Medicine
  - Glendale, Arizona, United States, 85308
    - Clinical Research Advantage, Inc./ Lenzmeier Family Medicine
  - Mesa, Arizona, United States, 85206
    - Novara Clinical Research
  - Mesa, Arizona, United States, 85213
    - Clinical Research Advantage, Inc.
  - Mesa, Arizona, United States, 85206
    - Clinical Research Advantage, Inc./Central Arizona Medical Associates, PC
  - Peoria, Arizona, United States, 85381
    - Sun Valley Arthritis Center, Limited
  - Phoenix, Arizona, United States, 85023
    - Arizona Research Center, Inc.
  - Phoenix, Arizona, United States, 85051
    - 43rd Medical Associates, P.C.
  - Phoenix, Arizona, United States, 85016
    - Lovelace Scientific Resources, Inc.
  - Phoenix, Arizona, United States, 85018
    - Clinical Research Advantage, Inc./ Family Practice Specialists, LTD
  - Phoenix, Arizona, United States, 85020
    - NPHC Research
  - Phoenix, Arizona, United States, 85021
    - Phoenix Clinical
  - Phoenix, Arizona, United States, 85032
    - Precision Trials AZ. LLC; AZ
  - Scottsdale, Arizona, United States, 85258
    - Advanced Arthritis Care and Research
  - Scottsdale, Arizona, United States, 85254
    - Southwest Health Ltd.
  - Scottsdale, Arizona, United States, 85258
    - Arizona Pain Specialist, PLLC
  - Scottsdale, Arizona, United States, 85258
    - Sonora Quest Laboratories
  - Sierra Vista, Arizona, United States, 85635
    - Cochise Clinical Research
  - Tempe, Arizona, United States, 85283
    - Clinical Research Advantage, Inc./Fiel Family and Sports Medicine, PC
  - Tempe, Arizona, United States, 85282
    - Clinical Research Advantage, Inc./Skyline Medical Center PC
  - Tempe, Arizona, United States, 85282
    - Clinical Research Advantage, Inc./Urban Family Practice Associates, PC
  - Tempe, Arizona, United States, 85282
    - Clinical Research Advantage, Inc./Warner Family Practice, PC
  - Tempe, Arizona, United States, 85282
    - Clinical Research Advantage, Inc/Manning Family Care
  - Tempe, Arizona, United States, 85282
    - Clinical Research Advantage, Incl Colorado Springs Health Partners, East
  - Tempe, Arizona, United States, 85282
    - Family Medicine Associates/Clinical Research Advantage
  - Tucson, Arizona, United States, 85741
    - Genova Clinical Research
  - Tucson, Arizona, United States, 85745
    - Eclipse Clinical Research
  - Tucson, Arizona, United States, 85712
    - ARA-Arizona Research Associates
  - Tucson, Arizona, United States, 85712
    - Canyon Clinical Research LLC
  - Tucson, Arizona, United States, 85712
    - Tucson Clinical Researh
  - Tucson, Arizona, United States, 85715
    - ACRC/Arizona Clinical Research Center, Incorporated
  - Tucson, Arizona, United States, 85741
    - Clinical Research Advantage, Inc./ Orange Grove Family Practice
- Arkansas
  - Fayetteville, Arkansas, United States, 72703
    - Fayetteville Diagnostic Clinic Limited
  - Little Rock, Arkansas, United States, 72205
    - Lynn Institute of the Ozarks
  - Little Rock, Arkansas, United States, 72205
    - Hearne Family Practice Clinic
  - Little Rock, Arkansas, United States, 72205
    - Larry S. Watkins, M.D.
  - Little Rock, Arkansas, United States, 72205
    - Rx Medical Research of AR
- California
  - Anaheim, California, United States, 92805
    - Advanced Research Center
  - Anaheim, California, United States, 92804
    - Anaheim Family Medical Center
  - Artesia, California, United States, 90701
    - Advanced Arthritis & Rheumatology Center
  - Azusa, California, United States, 91702
    - Bina Akamdar MD
  - Bell, California, United States, 90201
    - Rx for Life, Inc
  - Carlsbad, California, United States, 92008
    - Clinical Research Advantage Inc., /Cassidy Medical Group-Carlsbad
  - Carmichael, California, United States, 95608
    - Northern California Research
  - Carmichael, California, United States, 95608
    - Capitol Interventional Cardiology
  - Encinitas, California, United States, 92024
    - CORE Orthopaedic Medical Center
  - Escondido, California, United States, 92025
    - Arthritis Medical Clinic of North County, Inc.
  - Fair Oaks, California, United States, 95628
    - Med Investigations, Inc.
  - Fresno, California, United States, 93720
    - Valley Research
  - Greenbrae, California, United States, 94904
    - Creekside Clinical Research
  - Hemet, California, United States, 92543
    - C. V. Mehta, MD Medical Corporation
  - Huntington Beach, California, United States, 92646
    - Talbert Medical Group
  - Huntington Park, California, United States, 90255
    - Alia Clinical Research, INC
  - Huntington Park, California, United States, 90255
    - Time Clinical Research Inc.
  - Irvine, California, United States, 92604
    - Lindora Research Center
  - Irvine, California, United States, 92618
    - Office of Dr. Robert L. Freed, MD
  - Laguna Hills, California, United States, 92653
    - Prime Care Clinical Research
  - Laguna Hills, California, United States, 92653
    - Office of Dr. Alan Schenk
  - Lakewood, California, United States, 90712
    - Jeremy Anuntiyo
  - Lakewood, California, United States, 90712
    - Premiere Clinical Research, LLC
  - Lakewood, California, United States, 90712
    - Stuart J. Finkelstein
  - Lincoln, California, United States, 95648
    - Clinical Trials Research
  - Loma Linda, California, United States, 92357
    - VA Loma Linda Healthcare System
  - Lomita, California, United States, 90717
    - Narbonne Multi-Specialty Medical Group Inc.
  - Long Beach, California, United States, 90806
    - Office of Dr. Arvind J. Mehta
  - Long Beach, California, United States, 90806
    - Pacific Internal Medicine Group, Inc
  - Long Beach, California, United States, 90807-0000
    - Long Beach Center For Clinical Research
  - Long Beach, California, United States, 90807
    - National Institute of Clinical Research
  - Long Beach, California, United States, 90813
    - Alliance Research, LLC
  - Los Alamitos, California, United States, 90720
    - Valerius Medical Group and Research Center
  - Los Angeles, California, United States, 90045
    - Pacific Arthritis Care Center
  - Los Angeles, California, United States, 90029
    - IMD Medical Group
  - Los Angeles, California, United States, 90057
    - Wagdy W. Kades, MD, Inc.
  - Los Gatos, California, United States, 95032
    - Samaritan Center for Medical Research Medical Group
  - Los Osos, California, United States, 93402
    - Office of Lewis Gamarra, MD M.P.H.
  - Lynwood, California, United States, 90262
    - Adegbenga A. Adetola, M.D.
  - Mission Hills, California, United States, 91345
    - Facey Medical Group
  - North Hollywood, California, United States, 91606
    - Providence Clinical Research
  - Palm Springs, California, United States, 92262
    - Desert Medical Group
  - Palos Verdes Estates, California, United States, 90274
    - The Office of Dr. Marcos Yang
  - Paramount, California, United States, 90723
    - Bayview Research Group, LLC
  - Roseville, California, United States, 95661
    - Sierra Rheumatology
  - Sacramento, California, United States, 95823
    - Center for Clinical Trials of Sacramento, Inc.
  - Sacramento, California, United States, 95825
    - Sacramento Heart and Vascular Research Center
  - San Diego, California, United States, 92108
    - San Diego Arthritis Medical Clinic
  - San Diego, California, United States, 92123
    - Medical Associates Research Group
  - San Diego, California, United States, 92103-6204
    - California Research Foundation
  - San Diego, California, United States, 92120
    - Wetlin Research Associates, Inc
  - San Jose, California, United States, 95116
    - San Jose Valley Research, Inc.
  - San Leandro, California, United States, 94578
    - Comprehensive Adult Risk Evaluation
  - San Leandro, California, United States, 94578
    - East Bay Rheumatology Medical Group Inc
  - San Luis Obispo, California, United States, 93405
    - Coastal Medical Research Group, Inc.
  - San Luis Obispo, California, United States, 93401
    - Central Coast Pathology Consultants
  - San Luis Obispo, California, United States, 93405
    - Family Medical Center
  - Santa Ana, California, United States, 92704
    - Office of Ajay G. Meka, MD
  - Santa Maria, California, United States, 93454
    - Pacific Arthritis Center Medical Group
  - Santa Monica, California, United States, 90404
    - Orrin M. Troum & Medical Associates
  - Santa Rosa, California, United States, 95403
    - Northern California Medical Associates
  - Sherman Oaks, California, United States, 91423
    - Robert Simon, MD
  - Stockton, California, United States, 95204
    - St. Joseph Medical Associates
  - Thousand Oaks, California, United States, 91360
    - Westlake Medical Research
  - Torrance, California, United States, 90503
    - Paradigm Clinical Research Institute, Inc.
  - Tustin, California, United States, 92780
    - Orange County Research Center
  - Upland, California, United States, 91786
    - Inland Rheumatology Clinical Trials, Inc.
  - Upland, California, United States, 91786
    - Inland Rheumatology and Osteoporosis Medical Group
  - Valley Village, California, United States, 91607
    - Bayview Research Group
  - Van Nuys, California, United States, 91405
    - Medvin Clinical Research
  - West Covina, California, United States, 91790
    - Center for Clinical Trials of San Gabriel
  - Whittier, California, United States, 90606
    - Agilence Arthritis and Osteoporosis Medical Center, Inc.
  - Wilmington, California, United States, 90744
    - Avalon Family Medical Group
- Colorado
  - Arvada, Colorado, United States, 80005
    - Darrell E. Gorman, MD
  - Aurora, Colorado, United States, 80012
    - Aurora Denver Cardiology Associates
  - Colorado Springs, Colorado, United States, 80920
    - Lynn Institute of the Rockies
  - Colorado Springs, Colorado, United States, 80918
    - Azmi Emil Farag, MD
  - Colorado Springs, Colorado, United States, 80922
    - Colorado Springs Health Partners- East/Clinical Research Advantage
  - Denver, Colorado, United States, 80209
    - Mountain View Clinical Research, Inc.
  - Fort Collins, Colorado, United States, 80525
    - Saint Luke's Medical Clinic
  - Golden, Colorado, United States, 80401
    - New West Physicians
  - Highlands Ranch, Colorado, United States, 80130
    - Ranch View Family Medicine
  - Lakewood, Colorado, United States, 80227
    - Colorado Center for Bone Research PC
  - Littleton, Colorado, United States, 80120
    - South Denver Cardiology Associates, PC
  - Pueblo, Colorado, United States, 81008
    - Lynn Institute of Pueblo
- Connecticut
  - Bridgeport, Connecticut, United States, 06606
    - Connecticut Clinical Research, Llc
  - Bristol, Connecticut, United States, 06010
    - Connecticut Gastroenterology Institute
  - Hamden, Connecticut, United States, 06518
    - Arthritis and Osteoporosis Center, PC
  - Hamden, Connecticut, United States, 06518
    - Robert Lang, MD, P.C.
  - New London, Connecticut, United States, 06320
    - Coastal Connecticut Research, LLC
  - New London, Connecticut, United States, 06320
    - Office of Edward J. McDermott, Jr., MD
  - Stamford, Connecticut, United States, 06905
    - Stamford Therapeutics Consortium
  - Stamford, Connecticut, United States, 06905
    - Orthopaedics Foundation for Active Lifestyles
  - Trumbull, Connecticut, United States, 06611
    - New England Research Associates, LLC
  - Waterbury, Connecticut, United States, 06708
    - Arthritis Center of Connecticut
- Delaware
  - Lewes, Delaware, United States, 19958
    - Rheumatology Consultants of Delaware
- District of Columbia
  - Washington, District of Columbia, United States, 20003
    - Office of Cynthia Morgan, MD
  - Washington, District of Columbia, United States, 20006
    - The Center For Rheumatology And Bone Research
- Florida
  - Atlantis, Florida, United States, 33462
    - Medical Specialist of the Palm Beaches
  - Aventura, Florida, United States, 33180
    - South Florida Medical Research
  - Boca Raton, Florida, United States, 33486
    - RASF - Clinical Research Center
  - Boynton Beach, Florida, United States, 33472
    - Orthopedic Research Institute
  - Brandon, Florida, United States, 33511
    - Clinical Research Of Brandon, LLC
  - Chipley, Florida, United States, 32428
    - Family Healthcare of Chipley
  - Chipley, Florida, United States, 32428
    - Health First Clinical Research Group, Inc.
  - Chipley, Florida, United States, 32428
    - Southern Family Healthcare and Health First Research Group Inc.
  - Clearwater, Florida, United States, 33756
    - Innovative Research of West Florida, Inc.
  - Clearwater, Florida, United States, 33765
    - Clinical Research of West Florida
  - Clearwater, Florida, United States, 33755
    - Florida Research & Testing, LLC
  - Clearwater, Florida, United States, 33756
    - Alba Clinical Research
  - Clearwater, Florida, United States, 33756
    - Appletree Medical
  - Cocoa, Florida, United States, 32927
    - Rameshwar N. Mathur, MD, PA
  - Crystal River, Florida, United States, 34429
    - Nature Coast Clinical Research, LLC
  - Daytona Beach, Florida, United States, 32114
    - Atlantic Institute of Clinical Research
  - Daytona Beach, Florida, United States, 32117
    - International Medical Research
  - DeBary, Florida, United States, 32713
    - Omega Research Consultants, LLC
  - DeBary, Florida, United States, 32713
    - Physicians Research Alliance, LLC
  - DeFuniak Springs, Florida, United States, 32435
    - Doctors Medical center of Walton County
  - DeLand, Florida, United States, 32720
    - Avail Clinical Research, LLC
  - DeLand, Florida, United States, 32720
    - Florida Research Associates, LLC/Florida Orthopaedic Associates, P.A.
  - Deerfield Beach, Florida, United States, 33442
    - Deerfield Beach Cardiology Associates
  - Delray Beach, Florida, United States, 33446
    - Cohen Medical Associates, PA
  - Destin, Florida, United States, 32540
    - Clark Family Medicine & Emerald Coast Research Group
  - Destin, Florida, United States, 32541
    - SJS Clinical Research, Inc
  - Dunedin, Florida, United States, 34698
    - Robert W. Levin MD
  - Edgewater, Florida, United States, 32132
    - Riverside Clinical Research
  - Fleming Island, Florida, United States, 32003
    - Fleming Island Center For Clinical Research
  - Fort Lauderdale, Florida, United States, 33308
    - Invesclinic
  - Fort Lauderdale, Florida, United States, 33316
    - M&O Clinical Research, LLC
  - Fort Lauderdale, Florida, United States, 33316
    - Maxine Hamilton, MD PA
  - Fort Lauderdale, Florida, United States, 33334
    - Holy Cross Medical Group Northridge Internal Medicine
  - Fort Myers, Florida, United States, 33912
    - Clinical Physiology Associates
  - Fort Walton Beach, Florida, United States, 32547
    - Emerald Coast Mood & Memory
  - Fort Walton Beach, Florida, United States, 32547
    - White-Wilson Medical Center, PA
  - Gainesville, Florida, United States, 32610
    - University of Florida
  - Gainesville, Florida, United States, 32610
    - Shands at the University of Florida
  - Gainesville, Florida, United States, 32605
    - Florida Research Network, LLC
  - Gainesville, Florida, United States, 32607
    - Southeastern Integrated Medical, PL
  - Gainesville, Florida, United States, 32605
    - Cardiology West
  - Hialeah, Florida, United States, 33012
    - Indago Research & Health Center, Inc.
  - Hialeah, Florida, United States, 33012
    - Reliable Clinical Research, LLC
  - Hialeah, Florida, United States, 33010
    - Genetic Medical Research Corporation
  - Hialeah, Florida, United States, 33012
    - Direct Helpers Medical Center, Inc.
  - Hollywood, Florida, United States, 33021
    - Orthopaedic Associates of South Broward, P.A.
  - Homestead, Florida, United States, 33030
    - Advanced Research Institute of Miami
  - Hudson, Florida, United States, 34667
    - Pasco Cardiology Center
  - Inverness, Florida, United States, 34452
    - Nature Coast Clinical Research
  - Jacksonville, Florida, United States, 32205
    - Westside Center for Clinical Research
  - Jacksonville, Florida, United States, 32216
    - East Coast Institute for Research, LLC
  - Jacksonville, Florida, United States, 32216
    - Jacksonville Center for Clincal Research
  - Jacksonville, Florida, United States, 32216
    - St. Vincent's Cardiology
  - Jupiter, Florida, United States, 33458
    - Drug Study Institute
  - Jupiter, Florida, United States, 33458
    - Dr. Ricardo A. Bedoya, M.D.
  - Kissimmee, Florida, United States, 34744
    - Christopher Chappel
  - Lake Mary, Florida, United States, 32746
    - Florida Arthritis Center, LLC
  - Lehigh Acres, Florida, United States, 33936
    - Pedro Ylisastigui, MD
  - Longwood, Florida, United States, 32779
    - Adult Medicine Specialists
  - Longwood, Florida, United States, 32779
    - Genesis Research International
  - Madeira Beach, Florida, United States, 33708
    - Doctors Inn
  - Marianna, Florida, United States, 32446
    - Everest Medical Care and Palm Court Research Group
  - Marianna, Florida, United States, 32446
    - Panhandle Family Care Associates & Emerald Coast Research Group
  - Marianna, Florida, United States, 32446
    - The Doctor's Office
  - Melbourne, Florida, United States, 32901
    - Holmes Regional Medical Center
  - Melbourne, Florida, United States, 32901
    - Health First Medical Group
  - Merritt Island, Florida, United States, 32953
    - Pharmaceutical Research Associates
  - Miami, Florida, United States, 33126
    - Pharmax Research Clinic
  - Miami, Florida, United States, 33175
    - New Horizon Research Center
  - Miami, Florida, United States, 33176
    - Miami Cardiology Group
  - Miami, Florida, United States, 33165
    - Future Care Solution, LLC
  - Miami, Florida, United States, 33137
    - Miami International Cardiology Consultants
  - Miami, Florida, United States, 33143
    - Well Pharma Medical Research Corporation
  - Miami, Florida, United States, 33142
    - Florida Medical Center & Research, Inc.
  - Miami, Florida, United States, 33032
    - Homestead Associates in Research, Inc
  - Miami, Florida, United States, 33134
    - Life Spring Research Foundation
  - Miami, Florida, United States, 33143
    - The Center for Arthritis and Rheumatic Diseases
  - Miami, Florida, United States, 33144
    - DC Health Clinical Trials
  - Miami, Florida, United States, 33144
    - School of Clinical Research USA, LLC
  - Miami, Florida, United States, 33165
    - Advance Medical Research Services, Corp
  - Miami, Florida, United States, 33185
    - M & M Medical Center
  - Miami, Florida, United States, 33186
    - Office of Dr. Juvenal E. Martinez, MD, PA
  - Miami Beach, Florida, United States, 33181
    - Orthopaedic Specialist of Miami Beach
  - Miami Gardens, Florida, United States, 33169
    - AMPM Research Clinic
  - Miami Lakes, Florida, United States, 33014
    - Crystal Biomedical Research, LLC
  - Miami Lakes, Florida, United States, 33014
    - Pembroke Clinical Trials
  - Naples, Florida, United States, 34102
    - Anchor Research Center
  - Naples, Florida, United States, 34102
    - Jeffrey Alper M.D. Research
  - Naples, Florida, United States, 34108
    - Anchor Health Centers
  - Naples, Florida, United States, 34119
    - Medical Surgical Specialists, Physicians Regional Medical Center
  - New Port Richey, Florida, United States, 34652
    - Suncoast Clinical Research, Inc.
  - Ocala, Florida, United States, 34474
    - Ocala Rheumatology Research Center
  - Ocala, Florida, United States, 34474
    - Paddock Park Clinical Research
  - Ocala, Florida, United States, 34471-5117
    - Magnolia Research Group, Inc.
  - Ocala, Florida, United States, 34474
    - Southeastern Rehabilitation Medicine
  - Ocala, Florida, United States, 34474
    - Tequesta Research Group
  - Ocoee, Florida, United States, 34761
    - CEC Research, INC.
  - Orlando, Florida, United States, 32806
    - Compass Research, LLC
  - Orlando, Florida, United States, 32803
    - Florida Hospital
  - Orlando, Florida, United States, 32803-1849
    - Florida Heart Group, PA
  - Orlando, Florida, United States, 32806
    - DCT FMC, LLC dba Discovery Clinical Trials
  - Orlando, Florida, United States, 32806
    - DCT-FMC, LLC dba Discovery Clinical Trials
  - Orlando, Florida, United States, 32814
    - Arthur L. Hall MD PA
  - Oviedo, Florida, United States, 32765
    - Block and Nation, PA
  - Palm Harbor, Florida, United States, 34684
    - Arthritis Research Of Florida, Inc.
  - Palm Harbor, Florida, United States, 34684
    - Florida Med Center of Countryside
  - Pembroke Pines, Florida, United States, 33027
    - South Broward Research LLC
  - Pembroke Pines, Florida, United States, 33024
    - Rene CaSanova Medical Office Inc
  - Pembroke Pines, Florida, United States, 33026
    - Boulevard Professional Centre
  - Pembroke Pines, Florida, United States, 33026
    - Research Physician Network Alliance
  - Pembroke Pines, Florida, United States, 33029
    - South Florida Research Solutions, LLC
  - Pinellas Park, Florida, United States, 33782
    - DMI Research, Inc.
  - Plantation, Florida, United States, 33322
    - Sunbelt Research, LLC
  - Plantation, Florida, United States, 33323
    - Boca Raton Clinical Research
  - Ponte Vedra, Florida, United States, 32081
    - St. Johns Center for Clinical Research
  - Port Orange, Florida, United States, 32129
    - Accord Clinical Research, LLC
  - Port Richey, Florida, United States, 34668
    - Administrative Address: Florida Arthritis & Osteoporosis Center
  - Sarasota, Florida, United States, 34239
    - Heart & Vascular Center Research
  - Sebastian, Florida, United States, 32958
    - Edgar R. Blecker, MD
  - Tamarac, Florida, United States, 33321
    - Phoenix Clinical Research, LLC.
  - Tampa, Florida, United States, 33603
    - Clinical Research of West Florida
  - Tampa, Florida, United States, 33613
    - Stedman Clinical Trials, LLC
  - Tampa, Florida, United States, 33609-3018
    - Soutwest Florida Clinical Research Center
  - Tampa, Florida, United States, 33609
    - Clinyx/Floria Cardiovascular
  - Tampa, Florida, United States, 33613
    - West Wind'r Research
  - Tampa, Florida, United States, 33614
    - Health Point Medical Group, Inc
  - Tampa, Florida, United States, 33619-6364
    - Causeway Medical Clinic
  - Vero Beach, Florida, United States, 32960
    - Office of Alastair C. Kennedy, MD
  - West Palm Beach, Florida, United States, 33409
    - Palm Beach Research Center
  - West Palm Beach, Florida, United States, 33401
    - Metabolic Research Institute, Incorporated
  - Winter Park, Florida, United States, 32792
    - Central Florida Primary Care
  - Zephyrhills, Florida, United States, 33542
    - Florida Medical Clinic, PA
- Georgia
  - Atlanta, Georgia, United States, 30342
    - Arthritis and Rheumatology of Georgia
  - Atlanta, Georgia, United States, 30309
    - Piedmont Heart Institute
  - Atlanta, Georgia, United States, 30342
    - Atlanta Vascular Research Foundation
  - Atlanta, Georgia, United States, 30308
    - The Kaufmann Clinic
  - Atlanta, Georgia, United States, 30342
    - Atlanta Center for Clinical Research, Corp.
  - Atlanta, Georgia, United States, 30342
    - Executive Health and Research Associates
  - Augusta, Georgia, United States, 30909
    - Masters of Clinical Research, Inc.
  - Augusta, Georgia, United States, 30904
    - Southern Clinical Research and Management, Inc. (SCRAM)
  - Bainbridge, Georgia, United States, 39819
    - Amelia Medical Plaza
  - Bainbridge, Georgia, United States, 39819
    - Bainbridge Medical Associates
  - Cairo, Georgia, United States, 39828
    - Abdul Bari MD Inc
  - Cairo, Georgia, United States, 39828
    - Southern Clinical Research Management and Consulting
  - Duluth, Georgia, United States, 30096
    - North Georgia Rheumatology Group, PC
  - Gainesville, Georgia, United States, 30501
    - United Osteoporosis Centers
  - Lawrenceville, Georgia, United States, 30046
    - North Georgia Rheumatology Group, PC
  - Lilburn, Georgia, United States, 30047
    - GCH Research Dr. G Craig Heigerick DO
  - Macon, Georgia, United States, 31201
    - Mercer University Mercer Medicine
  - Marietta, Georgia, United States, 30060
    - Drug Studies America
  - Marietta, Georgia, United States, 30066
    - Drug Studies America
  - Marietta, Georgia, United States, 30067
    - Clinical Research Advantage, Inc./Urban Family Practice Associates, PC
  - Norcross, Georgia, United States, 30071
    - In-Quest Medical Research, LLC
  - Rome, Georgia, United States, 30165-1698
    - Harbin Clinic
  - Roswell, Georgia, United States, 30075
    - Atlanta Center for Clinical Research
  - Suwanee, Georgia, United States, 30024
    - Herman Clinical Research, LLC
  - Thomasville, Georgia, United States, 31792
    - Archibold Primary Care
  - Tucker, Georgia, United States, 30084
    - Clinical Trial Providers, Inc.
  - Valdosta, Georgia, United States, 31602
    - VSC
  - Woodstock, Georgia, United States, 30189
    - North Georgia Clinical Research
  - Woodstock, Georgia, United States, 30189
    - North Georgia Internal Medicine
  - Woodstock, Georgia, United States, 30188
    - Kaufmann Clinic, INC
- Hawaii
  - Honolulu, Hawaii, United States, 96814
    - East-West Medical Research Institute
- Idaho
  - Boise, Idaho, United States, 83702
    - Orthopedic Health Care Clinic
  - Boise, Idaho, United States, 83702
    - Sonora Clinical Research, LLC
  - Boise, Idaho, United States, 83713-0997
    - Eagle's View Family Medicine
  - Coeur d'Alene, Idaho, United States, 83814
    - Coeur D'Alene Arthritis Clinic
  - Eagle, Idaho, United States, 83616
    - CTL Research
  - Idaho Falls, Idaho, United States, 83404
    - Women's Healthcare Associates P.A. dba Rosemark WomenCare Specialists
  - Meridian, Idaho, United States, 83642
    - Advanced Clinical Research
  - Meridian, Idaho, United States, 83642-6356
    - Idaho Arthritis and Osteoporosis Center
- Illinois
  - Aurora, Illinois, United States, 60506
    - AMR Sakeena Research
  - Bloomingdale, Illinois, United States, 60108
    - Arthur I Davida, MD PC
  - Chicago, Illinois, United States, 60617
    - Claude Mandel Medical Center
  - Chicago, Illinois, United States, 60611
    - Cardiac Wellness Consultants
  - Chicago, Illinois, United States, 60611
    - Chicago Peripheral Nerve Center
  - Chicago, Illinois, United States, 60611
    - ICCT Research International Incorporated
  - Evanston, Illinois, United States, 60202
    - Windy City Orthopedics and Sports Medicine
  - Hazel Crest, Illinois, United States, 60429
    - South Suburban Health Professional Group
  - Joliet, Illinois, United States, 60435
    - Prairie Rheumatology Associates, SC
  - Lake Zurich, Illinois, United States, 60047
    - Lake Zurich Family Treatment Center
  - O'Fallon, Illinois, United States, 62269
    - Southern Illiniois Clinical Research Centre
  - Olympia Fields, Illinois, United States, 60461
    - Speciality phhysicians of Illinois, LLC
  - Peoria, Illinois, United States, 61614
    - Redhead Research Inc., dba Research Associates of Central Illinois
  - Rock Island, Illinois, United States, 61201
    - Trinity Medical Center
  - Rockford, Illinois, United States, 61103
    - Rockford Health Physicians
  - Springfield, Illinois, United States, 62702
    - Springfield Clinic
  - Springfield, Illinois, United States, 62703
    - Springfield Clinic
  - Springfield, Illinois, United States, 62701
    - Prairie Cardiovascular Consultants
  - Springfield, Illinois, United States, 62701
    - Prairie Education & Research
  - Vernon Hills, Illinois, United States, 60061
    - Deerbrook Medical Associates
- Indiana
  - Anderson, Indiana, United States, 46011
    - Community Clinical Research Center
  - Avon, Indiana, United States, 46123
    - American Health Network of Indiana, LLC
  - Evansville, Indiana, United States, 47714
    - Clinical Research Advantage, Inc.
  - Evansville, Indiana, United States, 47714
    - Destiny Clinical Research, LLC
  - Evansville, Indiana, United States, 47710
    - Robert D. Barnes, MD, LLC
  - Evansville, Indiana, United States, 47725
    - Clinical Research Advantage/Family Medicine Associates
  - Franklin, Indiana, United States, 46131
    - American Health Network of Indiana, LLC
  - Gary, Indiana, United States, 46409
    - Internal Medicine Center of Northwest Indiana, P.C.
  - Granger, Indiana, United States, 46530
    - Beacon Medical Group Rheumatology
  - Greenfield, Indiana, United States, 46140-2834
    - American Health Network of IN, LLC
  - Indianapolis, Indiana, United States, 46256
    - Dawes Fretzin Clinical Research Group, LLC
  - Indianapolis, Indiana, United States, 46256
    - Dawes Fretzin Dermatology Group, LLC
  - Indianapolis, Indiana, United States, 46227
    - Diagnostic Rheumatology And Research, PC
  - Indianapolis, Indiana, United States, 46234
    - Investigators Research Group
  - Jeffersonville, Indiana, United States, 47130
    - Arthritis Associates of Southern Indiana
  - Jeffersonville, Indiana, United States, 47130
    - Research Institute of Middle America/River Cities Cardiology
  - LaPorte, Indiana, United States, 46350
    - Beacon Medical Group LaPorte
  - Merrillville, Indiana, United States, 46410
    - Cardiovascular Clinics, PC
  - Muncie, Indiana, United States, 47304
    - Community Clinical Research Center
  - Munster, Indiana, United States, 46321
    - Medical Specialists Clinical Research Center
  - Munster, Indiana, United States, 46321
    - Medical Specialists
  - New Albany, Indiana, United States, 47150
    - Arthritis Associates of Southern Indiana
  - Valparaiso, Indiana, United States, 46383
    - Buynak Clinical Research
- Iowa
  - Cedar Rapids, Iowa, United States, 52403
    - Physician's Clinic of Iowa, PC
  - Council Bluffs, Iowa, United States, 51503
    - Ridge Family Practice, PC/Clinical Research Advantage, Inc.
  - Davenport, Iowa, United States, 52803
    - Midwest Cardiovascular Research Foundation
  - Des Moines, Iowa, United States, 50316
    - Office of Jerrold V Flatt
  - Dubuque, Iowa, United States, 52002
    - Medical Associates Clinic, PC
  - Waterloo, Iowa, United States, 50701
    - Family Health Center of Waterloo, PC
  - Waterloo, Iowa, United States, 50702
    - Northeast IA Medical Education Foundation/Family Practice Center
- Kansas
  - Arkansas City, Kansas, United States, 67005
    - Heartland Research Associates LLC
  - Kansas City, Kansas, United States, 66104
    - Community House of Wellness
  - Lansing, Kansas, United States, 66043
    - Associates Reseach Inc.
  - Overland Park, Kansas, United States, 66215
    - Pinnacle Medical Research
  - Overland Park, Kansas, United States, 66210
    - Radiant Research, Inc.
  - Overland Park, Kansas, United States, 66211
    - International Clinical Research Institute, Inc
  - Overland Park, Kansas, United States, 66215
    - Arthritis Specialists of Greater KC
  - Overland Park, Kansas, United States, 66215
    - Quivira Internal Medicine
  - Pratt, Kansas, United States, 67124
    - Health Science Research Center
  - Wichita, Kansas, United States, 67205
    - Heartland Research Associates, LLC
  - Wichita, Kansas, United States, 67208
    - Via Christi Clinic
- Kentucky
  - Ashland, Kentucky, United States, 41101
    - Howard L. Feinberg, D.O.
  - Bowling Green, Kentucky, United States, 42101
    - Graves Gilbert Clinic
  - Bowling Green, Kentucky, United States, 42101-1759
    - Graves Gilbert Clinic
  - Campbellsville, Kentucky, United States, 42718
    - Internal Medicine Research Association
  - Elizabethtown, Kentucky, United States, 42701
    - Center For Arthritis and Osteoporosis
  - Lexington, Kentucky, United States, 40504
    - Arthritis Center of Lexington
  - Louisville, Kentucky, United States, 40202
    - University Medical Associates
  - Louisville, Kentucky, United States, 40213
    - Louisville Metabolic and Atherosclerosis Research Center
  - Louisville, Kentucky, United States, 40202
    - Kentuckiana Center for Better Bone and Joint Health
  - Louisville, Kentucky, United States, 40202
    - KY Research PLLC.
  - Richmond, Kentucky, United States, 40475
    - Office of Gaurang B. Shah,MD, PSC
  - Richmond, Kentucky, United States, 40475
    - Richmond Regional Research
- Louisiana
  - Bossier City, Louisiana, United States, 71111
    - Chandler Family Practice
  - Shreveport, Louisiana, United States, 71105
    - McFarland Family Clinic
  - Shreveport, Louisiana, United States, 71115
    - TFD Research, LLC
- Maine
  - Auburn, Maine, United States, 04210
    - Maine Research Associates
  - Biddeford, Maine, United States, 04005
    - Southern Maine Health Care
  - Lewiston, Maine, United States, 04240
    - Central Maine Heart & Vascular Institute
- Maryland
  - Baltimore, Maryland, United States, 21209
    - Health Trends Research, LLC
  - Baltimore, Maryland, United States, 21204
    - Chesapeake Cardiovascular Associates
  - Baltimore, Maryland, United States, 21204
    - Midatlantic Cardiovascular Associates
  - Baltimore, Maryland, United States, 21208
    - Midatlantic Cardiovascular Associates, Pa
  - Baltimore, Maryland, United States, 21215
    - One Heart, LLC
  - Baltimore, Maryland, United States, 21218
    - Chesapeake Cardiovascular Associates
  - Baltimore, Maryland, United States, 21229
    - Midatlantic Cardiovascular Associates, Pa
  - Baltimore, Maryland, United States, 21229
    - Saint Agnes HealthCare Incorporated
  - Baltimore, Maryland, United States, 21234-4607
    - Stephen R Smith, MD FACP
  - Baltimore, Maryland, United States, 21237
    - Midatlantic Cardiovascular Associates, Pa
  - Baltimore, Maryland, United States, 21239
    - Peter A. Holt
  - Bel Air, Maryland, United States, 21014
    - Midatlantic Cardiovascular Associates PA
  - Charlotte Hall, Maryland, United States, 20622
    - Shah Associates MD, LLC
  - Columbia, Maryland, United States, 21044
    - Johns Hopkins University
  - Columbia, Maryland, United States, 21044-2914
    - Cardiovascular Specialists, LLC
  - Cumberland, Maryland, United States, 21502
    - The Osteoporosis & Clinical Trials Center
  - Frederick, Maryland, United States, 21702
    - Arthritis Treatment Center
  - Greenbelt, Maryland, United States, 20770
    - The Spine & Joint Center
  - Hagerstown, Maryland, United States, 21740
    - Klein & Associates, MD, PA
  - North East, Maryland, United States, 21901
    - Community Health Research
  - Oxon Hill, Maryland, United States, 20745
    - MD Medical Research
  - Prince Frederick, Maryland, United States, 20678
    - Shah Associates
  - Rockville, Maryland, United States, 20850
    - Cardiac Associates, Shady Grove Adventist Hospital
  - Rockville, Maryland, United States, 20850
    - The Center For Rheumatology And Bone Research
  - Rockville, Maryland, United States, 20854
    - Rockville Internal Medicine Group
  - Towson, Maryland, United States, 21204
    - IRC Clinics
  - Westminster, Maryland, United States, 21157-6160
    - Midatlantic Cardiovascular Associates, P.A.
  - Wheaton, Maryland, United States, 20902
    - The Center For Rheumatology And Bone Research
- Massachusetts
  - Ayer, Massachusetts, United States, 01432
    - Primary Care Cardiology Research
  - Fall River, Massachusetts, United States, 02720
    - Phase III Clinical Research
  - Fall River, Massachusetts, United States, 02720
    - Genesis Clinical Research & Consulting
  - Fall River, Massachusetts, United States, 02720
    - NECCR Internal Medicine and Cardiology Associates, LLC
  - Haverhill, Massachusetts, United States, 01830
    - Pentucket Medical Associates, Incorporated
  - Hyannis, Massachusetts, United States, 02601
    - Clinical Research Center of Cape Cod, Inc.
  - Natick, Massachusetts, United States, 01760
    - Charles River Medical Associates, Pchi
  - New Bedford, Massachusetts, United States, 02740
    - Novex Clinical Research, LLC
  - Northampton, Massachusetts, United States, 01062
    - Northampton Internal Medicine Associates, PC
  - Springfield, Massachusetts, United States, 01105
    - FutureCare Studies
  - Worcester, Massachusetts, United States, 01605
    - Reliant Medical Group, Inc.
- Michigan
  - Bay City, Michigan, United States, 48706
    - Great Lakes Research Group, Incorporated
  - Benzonia, Michigan, United States, 49616
    - Professional Clinical Research-Benzonia
  - Cadillac, Michigan, United States, 49601
    - Cadillac Clinical Research
  - Detroit, Michigan, United States, 48221
    - Livernois Family Medical Services
  - Eaton Rapids, Michigan, United States, 48827
    - Office of Dr. Susan Courtnage
  - Flint, Michigan, United States, 48532
    - McLaren Regional Medical Center-Research Dept.
  - Grand Rapids, Michigan, United States, 49506
    - Grand Valley Medical Specialist, PLC
  - Grand Rapids, Michigan, United States, 49506
    - Spectrum Health Medical Group-Rheumatology
  - Grand Rapids, Michigan, United States, 49546
    - Michigan Medical Cardiovascular PC
  - Interlochen, Michigan, United States, 49643
    - Professional Clinical Research
  - Lansing, Michigan, United States, 48910-8595
    - Justus J Fiechtner, MD
  - Saginaw, Michigan, United States, 48601
    - Michigan CardioVascular Institute
  - Saginaw, Michigan, United States, 48602
    - Synergy Medical Education Alliance
  - Saint Clair Shores, Michigan, United States, 48081
    - Shores Rheumatology
  - Troy, Michigan, United States, 48085
    - Oakland Medical Research Center
  - Troy, Michigan, United States, 48098
    - Troy Internal Medicine Research
- Minnesota
  - Duluth, Minnesota, United States, 55805
    - St. Luke's Hospital Association of Duluth
  - Duluth, Minnesota, United States, 55805
    - St. Luke's Hospital Association of Duluth, DBA St Luke's Rheumatology Assoc.
  - Duluth, Minnesota, United States, 55805
    - St. Luke's Hospital Association of Duluth, Inc.
  - Saint Cloud, Minnesota, United States, 56303-1901
    - Central Minnesota Heart Center at St. Cloud Hospital
  - Saint Paul, Minnesota, United States, 55102
    - St. Paul Heart Clinic
- Mississippi
  - Biloxi, Mississippi, United States, 39531
    - The Center for Clinical Trials
  - Port Gibson, Mississippi, United States, 39150
    - Planters Clinic
  - Tupelo, Mississippi, United States, 38801
    - North Mississippi Medical Clinics, Inc.
- Missouri
  - Cape Girardeau, Missouri, United States, 63703
    - Cape Girardeau Physicians Associates
  - Florissant, Missouri, United States, 63031
    - Patterson Medical Clinic / d.b.a. Prime Care Research Associates
  - Jefferson City, Missouri, United States, 65109
    - Jefferson City Medical Group
  - Jefferson City, Missouri, United States, 65101
    - Allergy Asthma Immunology Services, LLC
  - Kansas City, Missouri, United States, 64108-2792
    - University of Missouri Kansas City School of Medicine
  - Kansas City, Missouri, United States, 64108
    - Truman Medical Center, Inc.
  - Kansas City, Missouri, United States, 64133
    - Clinical Research Advantage, Inc./Manning Family Care, LLC
  - Saint Louis, Missouri, United States, 63141
    - Sundance Clinical Research, LLC
  - Saint Louis, Missouri, United States, 63128
    - St. Louis Center for Clinical Research
  - Saint Louis, Missouri, United States, 63131
    - Physician Groups, LC, DBA Rheumatology and Internal Medicine Associates
  - Saint Louis, Missouri, United States, 63139-2909
    - Southampton Healthcare, Inc.
  - Saint Louis, Missouri, United States, 63139
    - Barbara A. Caciolo, MD
  - Saint Louis, Missouri, United States, 63141
    - A & A Pain Institute
  - Springfield, Missouri, United States, 65807
    - Mercy Medical Research Institute
  - Washington, Missouri, United States, 63090
    - Patients First Health Care, LLC
- Montana
  - Kalispell, Montana, United States, 59901
    - Glacier View Research Institute, Cardiology
- Nebraska
  - Alliance, Nebraska, United States, 69301
    - Alliance Medical Center
  - Alliance, Nebraska, United States, 69301
    - Cody Medical Associates
  - Bellevue, Nebraska, United States, 68005
    - Bellevue Family Practice/Clinical Research Advantage, Inc.
  - Elkhorn, Nebraska, United States, 68022
    - Clinical Research Advantage, Inc./ Skyline Medical Center, PC
  - Fremont, Nebraska, United States, 68025
    - Clinical Research Advantage, Inc./Prairie Fields Family Medicine, PC
  - Grand Island, Nebraska, United States, 68803
    - Internal Medicine Associates, PC
  - Lincoln, Nebraska, United States, 68516
    - Lincoln Internal Medicine Associates
  - Lincoln, Nebraska, United States, 68512
    - Physician, Research Collaboration, Southwest Family Health
  - North Platte, Nebraska, United States, 69101
    - Platte River Nephrology
  - Omaha, Nebraska, United States, 68114
    - Westroads Medical Group
  - Omaha, Nebraska, United States, 68134
    - Heartland Clinical Research, Inc.
  - Omaha, Nebraska, United States, 68114
    - Quality Clinical Research LLC
  - Omaha, Nebraska, United States, 68144
    - Clinical Research Advantage, Inc./Primary Care Physicians, LLP
- Nevada
  - Henderson, Nevada, United States, 89014
    - Clinical Research Advantage, Inc.
  - Henderson, Nevada, United States, 89052
    - Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
  - Incline Village, Nevada, United States, 89451
    - Sierra Internal Medicine Associates
  - Las Vegas, Nevada, United States, 89104
    - Clinical Research Center of Nevada
  - Las Vegas, Nevada, United States, 89128
    - Clinical Research Advantage/Peter Philander, MD
  - Las Vegas, Nevada, United States, 89128
    - Rancho Internal Medicine
  - Las Vegas, Nevada, United States, 89130
    - Steven D. Folkerth, MD
  - Las Vegas, Nevada, United States, 89146
    - Ladner Family Practice
  - North Las Vegas, Nevada, United States, 89086
    - VA Southern Nevada Healthcare System
  - Reno, Nevada, United States, 89502
    - Arthritis Center of Reno
- New Jersey
  - Clifton, New Jersey, United States, 07012
    - New Jersey Physicians, LLC
  - Clifton, New Jersey, United States, 07013
    - Clifton-Wallington Medical Group
  - Edison, New Jersey, United States, 08817
    - Anderson and Collins, Clinical Research Inc.
  - Edison, New Jersey, United States, 08817
    - Drs. Collins and Uthappa
  - Elizabeth, New Jersey, United States, 07202
    - Central Jersey Health Care
  - Englewood, New Jersey, United States, 07631-2507
    - Andron Medical Associates
  - Haddon Heights, New Jersey, United States, 08035
    - Advocare Heights Primary Care
  - Hazlet, New Jersey, United States, 07730
    - Hazlet Health Care
  - Lawrenceville, New Jersey, United States, 08648
    - Family Care Physicians
  - Lawrenceville, New Jersey, United States, 08648
    - Penn Cardiac Care at Mercer Bucks
  - Lindenwold, New Jersey, United States, 08021
    - Family Medicine of Lindenwold
  - Medford, New Jersey, United States, 08055
    - Rheumatology and Arthritis Associates PC
  - Midland Park, New Jersey, United States, 07432-1969
    - Adult & Pediatric Rheumatology
  - Ridgewood, New Jersey, United States, 07450
    - The Valley Hospital
  - Sicklerville, New Jersey, United States, 08081
    - Maynard Holgado LLC
  - Toms River, New Jersey, United States, 08753
    - Shore Health Group
  - Trenton, New Jersey, United States, 08618
    - Hopewell Valley Medical Group, P.A.
  - Voorhees, New Jersey, United States, 08043
    - Arthritis, Rheumatic and Back Disease Associates, PA
  - Willingboro, New Jersey, United States, 08046
    - Lourdes Medical Associates
- New York
  - Babylon, New York, United States, 11702-2516
    - Kenneth F. Solinsky, MD
  - Brooklyn, New York, United States, 11214
    - Lifeline Research Institute
  - Dunkirk, New York, United States, 14048
    - Lee Medical Associates
  - Elmira, New York, United States, 14905
    - AMS Research
  - Endwell, New York, United States, 13760
    - Regional Clinical Research, Inc.
  - Hartsdale, New York, United States, 10530
    - Drug Trials America, Inc.
  - Johnson City, New York, United States, 13790
    - United Health Service Hospitals, Office of Clinical Trials
  - Kew Gardens, New York, United States, 11415
    - IMA Medical Research PC
  - Lake Success, New York, United States, 11042
    - NYU Langone Medical Center, Laura and Issac Perlmutter Cancer Center, Infusion Center
  - Lake Success, New York, United States, 11042
    - NYU Langone Medical Center, Laura and Issac Perlmutter Cancer Center, Investigational Pharmacy
  - Lake Success, New York, United States, 11042
    - NYU Langone Rheumatology Associates Long Island
  - Mamaroneck, New York, United States, 10543
    - Office of Dr. Allen Chodock
  - Mineola, New York, United States, 11501
    - Winthrop University Hospital / Clinical Trials Center
  - New York, New York, United States, 10016-4974
    - New York University Pain Management Center
  - New York, New York, United States, 10016
    - NYU Pain Research
  - New York, New York, United States, 10021
    - Office of Dr. Richard Stern
  - North Massapequa, New York, United States, 11758
    - DiGiovanna Family Care Center
  - Poughkeepsie, New York, United States, 12601
    - Hudson Valley Heart Center
  - Rochester, New York, United States, 14618
    - AAIR Research Center
  - Rosedale, New York, United States, 11422
    - Institute for clinical studies
  - Smithtown, New York, United States, 11787-2817
    - Rheumatology Associates of Long Island
  - Syosset, New York, United States, 11791
    - Office of Dr. Chadia Morcos
  - Syracuse, New York, United States, 13210-1775
    - Arthritis Health Associates
  - Syracuse, New York, United States, 13210
    - Crouse Medical Practice, PLLC d/b/a Internist Associates of Central New York
  - Wantagh, New York, United States, 11793
    - East Meadow Family Practice Associates, PC
  - West Seneca, New York, United States, 14224
    - Southgate Medical Group
  - Westfield, New York, United States, 14787
    - Great Lakes Medical Research
  - Williamsville, New York, United States, 14221
    - Upstate Clinical Research Associates
  - Williamsville, New York, United States, 14221
    - Buffalo Cardiology and Pulmonary Associates, PC
- North Carolina
  - Asheville, North Carolina, United States, 28803
    - Asheville Arthritis & Osteoporosis, PA
  - Burlington, North Carolina, United States, 27215
    - Kernodle Clinic Inc.
  - Calabash, North Carolina, United States, 28467
    - Calabash Medical Center
  - Cary, North Carolina, United States, 27518
    - PMG Research of Raleigh, LLC d/b/a PMG Research of Cary
  - Chapel Hill, North Carolina, United States, 27514
    - Chapel Hill Family Medicine
  - Chapel Hill, North Carolina, United States, 27599
    - Thurston Arthritis Reaserch Ctr
  - Charlotte, North Carolina, United States, 28277
    - Sensenbrenner Primary Care
  - Charlotte, North Carolina, United States, 28204
    - Mid Carolina Cardiology Research
  - Charlotte, North Carolina, United States, 28204
    - Presbyterian Novant Heart and Wellness
  - Charlotte, North Carolina, United States, 28207-1198
    - Arthritis and Osteoporosis Consultants of the Carolinas
  - Charlotte, North Carolina, United States, 28209-3734
    - PMG Research of Charlotte
  - Charlotte, North Carolina, United States, 28262
    - Barat Research Group, Inc.
  - Durham, North Carolina, United States, 27705
    - Duke Health Center at Pickett Road
  - Greensboro, North Carolina, United States, 27401
    - Bland Clinic, PA
  - Greensboro, North Carolina, United States, 27408
    - Medication Management, LLC
  - Greenville, North Carolina, United States, 27834
    - Physicians East, PA
  - Greenville, North Carolina, United States, 27834
    - Physicians East P. A.
  - Hickory, North Carolina, United States, 28602
    - PMG Research of Hickory, LLC
  - Hickory, North Carolina, United States, 28601
    - Clinical Trials of America, Inc.
  - High Point, North Carolina, United States, 27262
    - Peters Medical Research
  - Mooresville, North Carolina, United States, 28117
    - Research Institute of the Carolinas, PLLC
  - Morehead City, North Carolina, United States, 28557
    - Crystal Coast Family Practice
  - Morganton, North Carolina, United States, 28655
    - Burke Primary Care
  - Pinehurst, North Carolina, United States, 28374
    - Pinehurst Medical Clinic, INC.
  - Pinehurst, North Carolina, United States, 28374
    - Pinehurst Medical Clinic. Inc.
  - Raleigh, North Carolina, United States, 27612
    - Wake Research Associates, LLC
  - Raleigh, North Carolina, United States, 27609
    - PMG Research of Raleigh, LLC
  - Raleigh, North Carolina, United States, 27612
    - Wake Internal Medicine Consultants, Inc.
  - Raleigh, North Carolina, United States, 27607
    - Blue Ridge Family Physicians, PPLC
  - Rocky Mount, North Carolina, United States, 27804
    - Boice-Willis Clinic
  - Salisbury, North Carolina, United States, 28144
    - PMG Research of Salisbury
  - Tabor City, North Carolina, United States, 28463
    - Tabor City Family Medicine
  - Wilmington, North Carolina, United States, 28401
    - PMG Research of Wilmington
  - Wilmington, North Carolina, United States, 28401
    - PMG Research Wilmington Research Associates
  - Wilson, North Carolina, United States, 27893
    - Natalie A. Doyle, MD PA
  - Winston-Salem, North Carolina, United States, 27103
    - Clinical Trials of America, Inc.
  - Winston-Salem, North Carolina, United States, 27103
    - Winston-Salem Health Care
  - Winston-Salem, North Carolina, United States, 27103
    - PMG Research of Winston-Salem
  - Winston-Salem, North Carolina, United States, 27103
    - Ardmore Family Practice
  - Winston-Salem, North Carolina, United States, 27103
    - Clinical Trials of America, Inc
- North Dakota
  - Fargo, North Dakota, United States, 58104
    - Plains Clinical Research Center
- Ohio
  - Akron, Ohio, United States, 44313
    - Daystar Clinical Research
  - Cincinnati, Ohio, United States, 45242
    - CFP Research, Inc.
  - Cleveland, Ohio, United States, 44195
    - Cleveland Clinic
  - Cleveland, Ohio, United States, 44122
    - Rapid Medical Research, Inc.
  - Columbus, Ohio, United States, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, United States, 43214
    - MidWest Cardiology Research Foundation
  - Columbus, Ohio, United States, 43210-1228
    - The Ohio State University
  - Columbus, Ohio, United States, 43213
    - Feldman Family Practice
  - Columbus, Ohio, United States, 43215
    - Remington-Davis Incorporated
  - Columbus, Ohio, United States, 43228
    - Midtowne Family Practice Centre
  - Dayton, Ohio, United States, 45419
    - PriMed Clinical Research
  - Englewood, Ohio, United States, 45322
    - HWC Women's Research Center
  - Fairview Park, Ohio, United States, 44126
    - Cleveland Clinic Fairview Cardiovascular Medicine
  - Franklin, Ohio, United States, 45005
    - Prestige Clinical Research
  - Franklin, Ohio, United States, 45005
    - Triphase Research, Ltd.
  - Gallipolis, Ohio, United States, 45631
    - Holzer Clinic, Inc
  - London, Ohio, United States, 43140
    - Office of Dr. Saleem Khan, MD, Inc
  - Mansfield, Ohio, United States, 44903
    - North Central Research
  - Mansfield, Ohio, United States, 44903
    - OhioHealth Research Institute
  - Marion, Ohio, United States, 43302
    - R&R Research-Smith Clinic
  - Mayfield, Ohio, United States, 44143
    - David R. Mandel, MD, Inc
  - Middleburg Heights, Ohio, United States, 44130
    - Paramount Medical Research and Consulting, Llc
  - Newark, Ohio, United States, 43055
    - Newark Physician Associates
  - Shaker Heights, Ohio, United States, 44120
    - Family Medicine and Occupational Health Center, Inc.
  - Tiffin, Ohio, United States, 44883
    - Abner Cordero, M.D.
  - Toledo, Ohio, United States, 43608
    - Mercy St Vincent Medical Center
  - Toledo, Ohio, United States, 43606
    - Arthritis Associates of Northwest Ohio, Inc.
  - Toledo, Ohio, United States, 43608
    - Toledo Cardiology Consultants c/o Cardiac Research
  - Toledo, Ohio, United States, 43614
    - South Toledo Internists
  - Toledo, Ohio, United States, 43614
    - University of Toledo Health Science Campus
  - Toledo, Ohio, United States, 43614
    - UT Medical Center Medicine Clinic
  - Trenton, Ohio, United States, 45067
    - Trenton Family Medicine
  - Willoughby Hills, Ohio, United States, 44094
    - Lake Medical Research, LLC
  - Zanesville, Ohio, United States, 43701
    - Pharmacotherapy Research Associates Incorporated
- Oklahoma
  - Norman, Oklahoma, United States, 73069
    - Lion Research
  - Oklahoma City, Oklahoma, United States, 73112
    - Lynn Health Science Institute
  - Oklahoma City, Oklahoma, United States, 73109
    - Integris Physicians Services
  - Oklahoma City, Oklahoma, United States, 73112
    - Integris Cardiovascular Physicians LLC
  - Oklahoma City, Oklahoma, United States, 73112
    - Integris Family Care Central
  - Oklahoma City, Oklahoma, United States, 73112
    - Integris Physician Services
  - Tulsa, Oklahoma, United States, 74135
    - Healthcare Research Consultants
- Oregon
  - Ashland, Oregon, United States, 97520
    - Integrated Medical Research, PC
  - Eugene, Oregon, United States, 97401
    - Oregon Medical Group Clinical Research
  - Eugene, Oregon, United States, 97401
    - Lane Medical Research Group
  - Eugene, Oregon, United States, 97401
    - Oregon Medical Group Adult Medicine Clinic
  - Medford, Oregon, United States, 97501
    - Institute of Diabetes and Endocrinology
  - Medford, Oregon, United States, 97504
    - Rogue Valley Physicians-Clinical Research Group
  - Portland, Oregon, United States, 97219-1940
    - Fanno Creek Clinic
  - Portland, Oregon, United States, 97219
    - Affinity Research
  - Portland, Oregon, United States, 97219
    - Portland Rheumatology Clinic, Llc
  - Portland, Oregon, United States, 97225
    - Internal Medicine Research
- Pennsylvania
  - Altoona, Pennsylvania, United States, 16602
    - University Orthopedics Center
  - Beaver, Pennsylvania, United States, 15009
    - Tri-State Medical Group
  - Bethlehem, Pennsylvania, United States, 18015
    - East Penn Rheumatology Associates, Pc
  - Buckingham, Pennsylvania, United States, 18912
    - Buckingham Family Medicine
  - Camp Hill, Pennsylvania, United States, 17011
    - Camp Hill Clinical Research Center
  - Chicora, Pennsylvania, United States, 16025
    - Butler Medical Associates
  - Collegeville, Pennsylvania, United States, 19426-3626
    - Perkiomen Valley Family Practice, PC
  - Colmar, Pennsylvania, United States, 18915
    - Rheumatology Associates, LTD
  - Connellsville, Pennsylvania, United States, 15425
    - Office of J. Miller Oppy, MD, Youghiogheny Primary Care Practice
  - Downingtown, Pennsylvania, United States, 19335
    - Brandywine Clinical Research
  - Duncansville, Pennsylvania, United States, 16635
    - Altoona Center for Clinical Research
  - Erie, Pennsylvania, United States, 16508
    - Arthritis Associates
  - Erie, Pennsylvania, United States, 16502
    - Saint Vincent Consultant in Cardiovascular Diseases, LLC
  - Erie, Pennsylvania, United States, 16508
    - Center For Assessment And Research Of Erie
  - Erie, Pennsylvania, United States, 16509
    - Stan F. Slabic, M.D.
  - Feasterville, Pennsylvania, United States, 19053
    - AMH Feasterville Family HealthCare Center
  - Greensburg, Pennsylvania, United States, 15601
    - Westmoreland Neurology Associates, Incorporated
  - Harleysville, Pennsylvania, United States, 19438-2513
    - Harleysville Medical Assoc
  - Harleysville, Pennsylvania, United States, 19438
    - Lederach Family Medicine
  - Huntingdon Valley, Pennsylvania, United States, 19006
    - Dr. Bruce Morrison, Family Practice
  - Lansdale, Pennsylvania, United States, 19446
    - Green and Seidner Family Practice Associates
  - Lansdale, Pennsylvania, United States, 19446
    - Detweiler Family Medicine and Associates, PC
  - Lansdale, Pennsylvania, United States, 19446
    - Lansdale Medical Group Family Practice
  - Morrisville, Pennsylvania, United States, 19067-5008
    - Bucks County Clinical Research
  - Norristown, Pennsylvania, United States, 19401
    - Pearl Clinical Research, Inc.
  - Philadelphia, Pennsylvania, United States, 19152
    - Founders Research Corporation
  - Philadelphia, Pennsylvania, United States, 19126
    - Lehigh Wellness Center Outpatient Services
  - Pittsburgh, Pennsylvania, United States, 15240
    - VA Pittsburgh Healthcare System
  - Pittsburgh, Pennsylvania, United States, 15206
    - VA Pittsburgh Healthcare System
  - Red Lion, Pennsylvania, United States, 17356
    - Dairyland Medical Center
  - Scotland, Pennsylvania, United States, 17254
    - Sfm Clinical Trials, PC
  - Sellersville, Pennsylvania, United States, 18960
    - Elite Medical Research, Inc.
  - Springfield, Pennsylvania, United States, 19064
    - Prime Health Network
  - State College, Pennsylvania, United States, 16801
    - University Orthopedics Center
  - Stoneboro, Pennsylvania, United States, 16153
    - The Office of Dr. Joseph T. Morelli, DO
  - Tipton, Pennsylvania, United States, 16684
    - Tipton Medical and Diagnostic Center
  - Uniontown, Pennsylvania, United States, 15401
    - Pish Medical Associates
  - Upper Saint Clair, Pennsylvania, United States, 15241
    - PEAK Research, LLC
  - Wexford, Pennsylvania, United States, 15090
    - Allegheny Rheumatology - WPAHS - ASRI
  - Wyomissing, Pennsylvania, United States, 19610
    - Clinical Research Center of Reading, LLC
  - Yardley, Pennsylvania, United States, 19067
    - Cardiology Consultants of Philadelphia
  - Yardley, Pennsylvania, United States, 19067
    - Jeffry A. Lindenbaum DO, PC
- Rhode Island
  - Cranston, Rhode Island, United States, 02920
    - New England Center for Clinical Research
  - Cumberland, Rhode Island, United States, 02864
    - Partners in Clinical Research
  - Lincoln, Rhode Island, United States, 02865
    - Hugo M. Yamada, MD
  - Pawtucket, Rhode Island, United States, 02860
    - Rheumatology Associates
  - Providence, Rhode Island, United States, 02905
    - Medical Office Center
- South Carolina
  - Anderson, South Carolina, United States, 29621
    - AnMed Health
  - Anderson, South Carolina, United States, 29621
    - Anderson Heart
  - Charleston, South Carolina, United States, 29406
    - Clinical Trials of South Carolina
  - Charleston, South Carolina, United States, 29406-9333
    - Low Country Rheumatology, PA/Low Country Research Center
  - Charleston, South Carolina, United States, 29407
    - St. Andrews Medical
  - Columbia, South Carolina, United States, 29204
    - Medtrial
  - Columbia, South Carolina, United States, 29201
    - Neem Research Group Inc.
  - Columbia, South Carolina, United States, 29204
    - Columbia Arthritis Center Pa
  - Florence, South Carolina, United States, 29501
    - Clinical Research Associates, LLC
  - Greenville, South Carolina, United States, 29601
    - Paris View Family Practice
  - Greenville, South Carolina, United States, 29601
    - Palmetto Clinical Trial Services, LLC
  - Greer, South Carolina, United States, 29651
    - Mountain View Clinical Research, Inc.
  - Greer, South Carolina, United States, 29651
    - DeGarmo Institute of Medical Research
  - Greer, South Carolina, United States, 29650
    - Radiant Research, Inc
  - Greer, South Carolina, United States, 29650
    - John Milas
  - Laurens, South Carolina, United States, 29360
    - Palmetto Clinical Trial Services, LLC at the Family Healthcare Center
  - Moncks Corner, South Carolina, United States, 29461
    - Berkeley Medical Center
  - Mount Pleasant, South Carolina, United States, 29464
    - PMG Research of Charleston
  - North Myrtle Beach, South Carolina, United States, 29582
    - North Myrtle Beach Family Practice
  - Orangeburg, South Carolina, United States, 29115-4931
    - Coulter Clinic
  - Orangeburg, South Carolina, United States, 29118
    - Orangeburg Medical Associates, PA
  - Rock Hill, South Carolina, United States, 29732
    - The Carolina Center for Rheumatology & Arthritis Care, PA
  - Simpsonville, South Carolina, United States, 29681
    - Hillcrest Clinical Research, LLC
  - Simpsonville, South Carolina, United States, 29681
    - Hillcrest Family Practice
  - Spartanburg, South Carolina, United States, 29302
    - Palmetto Research
  - Summerville, South Carolina, United States, 29485
    - Palmetto Clinical Research
  - Taylors, South Carolina, United States, 29687
    - Southeastern Research Associates, Inc.
- South Dakota
  - Aberdeen, South Dakota, United States, 57401
    - Odyssey Research/Sanford Clinic - Aberdeen
  - Aberdeen, South Dakota, United States, 57401
    - Sanford Clinic - Aberdeen
  - Rapid City, South Dakota, United States, 57702
    - Health Concepts
  - Rapid City, South Dakota, United States, 57701
    - Regional Health Clinic Research
  - Rapid City, South Dakota, United States, 57701
    - Regional Medical Clinic-Rheumatology
  - Watertown, South Dakota, United States, 57201
    - Brown Clinic PLLP
  - Watertown, South Dakota, United States, 57201
    - Odyssey Research
- Tennessee
  - Bristol, Tennessee, United States, 37620
    - Holston Medical Group
  - Bristol, Tennessee, United States, 37620
    - Pmg Research of Bristol
  - Bristol, Tennessee, United States, 37620
    - Internal Medicine & Pediatric Associates of Bristol
  - Fayetteville, Tennessee, United States, 37334
    - Parkway Medical Group
  - Germantown, Tennessee, United States, 38138
    - Stern Cardiovascular Foundation, Inc.
  - Jackson, Tennessee, United States, 38305
    - Arthritis Clinic
  - Jackson, Tennessee, United States, 38305
    - The Jackson Clinic, PA
  - Johnson City, Tennessee, United States, 37604
    - State of Franklin Healthcare Associates Clinical Research
  - Kingsport, Tennessee, United States, 37660
    - Holston Medical Group
  - Kingsport, Tennessee, United States, 37660
    - Holston Valley Surgery Center
  - Memphis, Tennessee, United States, 38119-5214
    - Gupta, Ramesh C MD
  - Nashville, Tennessee, United States, 37205
    - Nashville Medical Research Institute
  - Nashville, Tennessee, United States, 37211
    - Quality Medical Research
  - Nashville, Tennessee, United States, 37203
    - Access Clinical Trials, Inc.
  - Nashville, Tennessee, United States, 37203
    - Premier Orthopaedics
  - Nashville, Tennessee, United States, 37203
    - The Cholesterol Center of Nashville
- Texas
  - Amarillo, Texas, United States, 79106
    - Amarillo Medical Specialists, LLP
  - Amarillo, Texas, United States, 79106
    - Pharma Tex Research, LLC
  - Arlington, Texas, United States, 76013
    - Family Health Care Association
  - Arlington, Texas, United States, 76017
    - South Arlington Primary Care Associates PA
  - Arlington, Texas, United States, 76018
    - DCT - Anchor, LLC dba Discovery Clinical Trials
  - Austin, Texas, United States, 78758
    - DCT-AACT, LLC dba Discovery Clinical Trials
  - Beaumont, Texas, United States, 77702
    - Southeast Texas Clinical Research Center
  - Beaumont, Texas, United States, 77702
    - Southeast Texas Cardiology Associates
  - Bedford, Texas, United States, 76021
    - Kaner Medical Group PA
  - Bedford, Texas, United States, 76021
    - Nexxus Research Group, LLC
  - Bedford, Texas, United States, 76021
    - Texas Orthopedic Specialists, PLLC
  - Carrollton, Texas, United States, 75007
    - MedicalEdge Healthcare Group, PA, dba Leading Edge Research, PA
  - Colleyville, Texas, United States, 76034
    - Prentiss Family Medicine
  - Corpus Christi, Texas, United States, 78405
    - Carlos B. Everett, MD
  - Corpus Christi, Texas, United States, 78411
    - Discovery Clinical Research
  - Dallas, Texas, United States, 75231
    - Metroplex Clinical Research Center
  - Dallas, Texas, United States, 75220
    - Texas Health Physicians Group
  - Dallas, Texas, United States, 75226
    - Soltero Cardiovascular Research Center/Baylor University Medical Center
  - Dallas, Texas, United States, 75231
    - Arthritis Care And Diagnostic Center, P.A.
  - Dallas, Texas, United States, 75231
    - Medical Specialists Associated
  - Dallas, Texas, United States, 75231
    - Southwest Rheumatology, P.A.
  - Dallas, Texas, United States, 75254
    - DCT - Genesis Neighborhood Research, LLC dba Discovery Clinical Trials
  - El Paso, Texas, United States, 79902
    - Rajendra K. Marwah, MD
  - Euless, Texas, United States, 76039
    - Kaner Medical Group, PA
  - Fort Worth, Texas, United States, 76104
    - The Medical Group Of Texas
  - Fort Worth, Texas, United States, 76107
    - Texas Health Physicians Group
  - Fort Worth, Texas, United States, 76117
    - T & R Clinic, P. A.
  - Galveston, Texas, United States, 77555
    - Rheumatology-UTMB
  - Garland, Texas, United States, 75041
    - Towngate Plaza Medical Center
  - Grand Prairie, Texas, United States, 75052
    - ProCare Clinical Trials
  - Houston, Texas, United States, 77008
    - Salim Gopalani, MD, PA
  - Houston, Texas, United States, 77024
    - Village Family Practice
  - Houston, Texas, United States, 77004
    - The Office of Amer Zaheer MD, PA
  - Houston, Texas, United States, 77024
    - Office of Cyril Wolf, MD
  - Houston, Texas, United States, 77025-1669
    - Kelsey Seybold Clinic
  - Houston, Texas, United States, 77074
    - Oxford Clinical Research, LLC
  - Houston, Texas, United States, 77079
    - MCA Research
  - Irving, Texas, United States, 75039
    - Texas Health Physicians Group
  - Lewisville, Texas, United States, 75057
    - One World Medical Associates, P.A.
  - Lewisville, Texas, United States, 75067
    - Pri-Med Care
  - McAllen, Texas, United States, 78501
    - South Texas Institute of Health
  - McKinney, Texas, United States, 75071
    - DCT - Genesis Seidmeyer Research, LLC dba Discovery Clinical Trials
  - Mesquite, Texas, United States, 75150
    - Southwest Rheumatology, PA
  - Midland, Texas, United States, 79707
    - Midland Clinical Research Center
  - Odessa, Texas, United States, 79761
    - Permian Research Foundation
  - Odessa, Texas, United States, 79761
    - Basin Orthopedics Surgical Specialists
  - Odessa, Texas, United States, 79761
    - Center for Hypertension and Internal Medicine
  - Odessa, Texas, United States, 79761
    - Odessa Heart Institute
  - Pasadena, Texas, United States, 77504
    - Office of David K. McDonald, M.D.. P.A.
  - Pharr, Texas, United States, 78577-5198
    - Centex Studies, Inc.
  - Plano, Texas, United States, 75075
    - Clinical Investigations of Texas, LLC
  - Plano, Texas, United States, 75093
    - North Texas Medical Research
  - Plano, Texas, United States, 75075
    - DCT-Genesis naini, LLC dba Discovery Clinical Trials
  - Richardson, Texas, United States, 75080
    - MedicalEdge Healthcare Group, PA
  - Richardson, Texas, United States, 75080
    - Texas Health Physicians Group
  - Richmond, Texas, United States, 77469
    - Ivan N. Mefford, MD, PhD, PA
  - San Antonio, Texas, United States, 78215
    - Sun Research Institute
  - San Antonio, Texas, United States, 78229
    - S.A.M. Clinical Research Center
  - San Antonio, Texas, United States, 78213
    - Gsa Research
  - San Antonio, Texas, United States, 78209
    - Quality Research Inc.
  - San Antonio, Texas, United States, 78217
    - Radiant Research San Antonio Northeast
  - San Antonio, Texas, United States, 78205
    - Paragon Research Center, LLC
  - San Antonio, Texas, United States, 78224
    - Briggs Clinical Research, LLC
  - San Antonio, Texas, United States, 78207
    - Quality Assurance Research Center
  - San Antonio, Texas, United States, 78212
    - Physician PrimeCare Research Institute, PLLC dba Health Texas Research Institute
  - San Antonio, Texas, United States, 78224
    - DCT - Barlite, LLC dba Discovery Clinical Trials
  - San Antonio, Texas, United States, 78229
    - Wellmed Clinical Research
  - San Antonio, Texas, United States, 78251
    - DCT-Westover Hills, LLC dba Discovery Clinical Trials
  - San Antonio, Texas, United States, 78258
    - DCT - Stone Oak, LLC dba Discovery Clinical Trials
  - San Antonio, Texas, United States, 78258
    - The Office of Shahbaz Yazdani, MD, PA
  - Southlake, Texas, United States, 76092
    - Southlake Clinical Trials
  - Sugar Land, Texas, United States, 77479
    - Sugar Land Med-Ped Clinic, PA
  - Victoria, Texas, United States, 77901
    - Crossroads Clinical Research
  - Victoria, Texas, United States, 77901
    - Crossroads Clinical Research, LLC
  - Webster, Texas, United States, 77598
    - Office of Pamela Dugano-Daphnis
- Utah
  - Ogden, Utah, United States, 84405
    - Advanced Research Institute
  - West Jordan, Utah, United States, 84088
    - Advanced Clinical Research
- Virginia
  - Burke, Virginia, United States, 22015
    - Burke Internal Medicine & Research
  - Burke, Virginia, United States, 22015
    - Burke Internal Medicine
  - Chesapeake, Virginia, United States, 23320-4985
    - Center for Arthritis and Rheumatic Diseases
  - Chesapeake, Virginia, United States, 23320
    - Bayview Physicians oa Cardiovascular Associates, Ltd
  - Chesapeake, Virginia, United States, 23320
    - David Ramstad, MD, MPH and Associates
  - Danville, Virginia, United States, 24541
    - Danville Internal Medicine, Inc.
  - Danville, Virginia, United States, 24541
    - Danville Orthopedic Clinic
  - Falls Church, Virginia, United States, 22044
    - Seven Corners Medical Research Center
  - Hampton, Virginia, United States, 23666
    - Hampton Family Practice
  - Manassas, Virginia, United States, 20110
    - Manassas Clinical Research Center
  - Newport News, Virginia, United States, 23601
    - Bruton Avenue Family Practice
  - Norfolk, Virginia, United States, 23502
    - Internal Medicine Kidney and Hypertension Center
  - Norfolk, Virginia, United States, 23502
    - Sentara Medical Group
  - Norfolk, Virginia, United States, 23502
    - National Clinical Research - Norfolk Inc.
  - Petersburg, Virginia, United States, 23803
    - Ettrick Health Center
  - Portsmouth, Virginia, United States, 23701
    - Arthritis and Rheumatic Research
  - Roanoke, Virginia, United States, 24014
    - Roanoke Heart Institute
  - Suffolk, Virginia, United States, 23435
    - Harbourview Professional Center
  - Virginia Beach, Virginia, United States, 23452
    - Chase Research Group, LLC
  - Williamsburg, Virginia, United States, 23185
    - The Center for Excellence in Aging and Geriatric Health
- Washington
  - Burien, Washington, United States, 98166
    - Highline Medical Center Laboratory
  - Seattle, Washington, United States, 98144
    - Puget Sound Osteoporosis Center
  - Seattle, Washington, United States, 98166-2967
    - Arthritis Northwest
  - Spokane, Washington, United States, 99204
    - Arthritis Northwest Rheumatology
  - Spokane, Washington, United States, 99204
    - Lawrence S. Eastburn, MD, PS
  - Spokane, Washington, United States, 99204
    - Pulmonary and Research Associates
  - Spokane, Washington, United States, 99216
    - The Office of William Gray, Md, Family Practice
  - Spokane, Washington, United States, 99218
    - John F. Long, D.O.
  - Tacoma, Washington, United States, 98405
    - Tacoma Center for Arthritis Research, PS
  - Tacoma, Washington, United States, 98405
    - George H. Krick, MD
  - Tacoma, Washington, United States, 98405
    - Northwest Family and Spinal Clinic
  - Tacoma, Washington, United States, 98405
    - Rheumatology Infusion Services
  - Wenatchee, Washington, United States, 98801
    - Wenatchee Valley Medical Center, Research Department
  - Yakima, Washington, United States, 98902
    - Clinical Trials Northwest
- West Virginia
  - Beckley, West Virginia, United States, 25801
    - Rheumatology and Pulmonary Clinic
  - Clarksburg, West Virginia, United States, 26301
    - Mountain State Clinical Research
  - Huntington, West Virginia, United States, 25701
    - University Cardiovascular Services. Robert C. Byrd Clinical Center
  - Lewisburg, West Virginia, United States, 24901
    - WVVA Healthcare Alliance
  - Parkersburg, West Virginia, United States, 26101
    - Parkersburg Cardiology Associates
- Wisconsin
  - Madison, Wisconsin, United States, 53713
    - Meriter Medical Group
  - Madison, Wisconsin, United States, 53715
    - University of Wisconsin School of Medicine and Public Health
  - Madison, Wisconsin, United States, 53715
    - UW Health Physicians
  - Milwaukee, Wisconsin, United States, 53295
    - Zablocki VA Medical Center
  - Milwaukee, Wisconsin, United States, 53215
    - St. Lukes Pain Management Center
  - Rhinelander, Wisconsin, United States, 54501
    - Aspirus Cardiovascular Associates - Rhinelander
  - Wausau, Wisconsin, United States, 54401
    - Aspirus Wausau Hospital
  - Wausau, Wisconsin, United States, 54401
    - Aspirus Cardiovascular Associates
  - Wausau, Wisconsin, United States, 54401
    - Aspirus Heart & Vascular lnstitute--Research & Education)
  - Wauwatosa, Wisconsin, United States, 53226
    - Allegiance Research Specialists, LLC

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Description

Inclusion Criteria:

Subjects with osteoarthritis or rheumatoid Arthritis with or at risk of developing cardiovascular disease and who require and eligible for chronic, daily therapy with an NSAID to control arthritis sign and symptoms.

Exclusion Criteria:

Subjects have had a recent cardiovascular event, unstable cardiovascular conditions, or any major surgery (cardiac or non-cardiac) within 3 months prior to randomization;
Subjects with medical or laboratory abnormality that would make the subject inappropriate for entry into this trial
Subjects require treatment with aspirin > 325 mg /day
Subjects with known hypersensitivity to celecoxib, ibuprofen, naproxen, aspirin or esomeprazole, etc.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Triple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: celecoxib subject receives celecoxib and dummy (placebo) ibuprofen and naproxen	Drug: celecoxib 100 to 200 mg twice daily, taken by mouth
Active Comparator: ibuprofen subject receives ibuprofen and dummy (placebo) celecoxib and naproxen	Drug: Ibuprofen ibuprofen 600 mg to 800 mg three times daily, taken by mouth
Active Comparator: naproxen subject receives naproxen and dummy (placebo) celecoxib and ibuprofen	Drug: Naproxen naproxen 375mg to 500 mg twice daily, taken by mouth

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The First Occurrence of Antiplatelet Trialists Collaboration (APTC) Composite Endpoint, Confirmed by the Clinical Events Committee (CEC). Time Frame: Intent to Treat (ITT) Population - 30 months; Modified ITT (MITT) Population - 42 months	APTC events are defined as a composite of any of the following events: Death due to CV causes (including cardiac, cerebrovascular, venous thromboembolic, haemorrhagic, other vascular, or unknown cause); Non-fatal MI; Non-fatal stroke (including intracranial hemorrhages, stroke of ischemic or unknown etiology).	Intent to Treat (ITT) Population - 30 months; Modified ITT (MITT) Population - 42 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The First Occurrence of a Major Adverse Cardiovascular Events (MACE) Time Frame: ITT Population - 30 months; MITT Population - 42 months	MACE defined as the composite of CV death (including hemorrhagic death), non-fatal MI, non-fatal stroke, hospitalization for UA, revascularization or hospitalization for TIA	ITT Population - 30 months; MITT Population - 42 months
The First Occurrence of Clinically Significant Gastrointestinal Events (CSGIE) Time Frame: ITT Population - 30 months; MITT Population - 42 months	CSGIE include: Gastroduodenal (GD) hemorrhage, Gastric outlet obstruction, Gastroduodenal, small bowel or large bowel perforation, Large bowel hemorrhage, Small bowel hemorrhage, Acute GI hemorrhage of unknown origin, including presumed small bowel hemorrhage, Symptomatic gastric or duodenal ulcer	ITT Population - 30 months; MITT Population - 42 months
Change From Baseline in Patient's Assessment of Arthritis Pain (VAS) Time Frame: ITT and MITT Population - Baseline to 42 months	VAS question "How much pain do you have" was graded on a scale from 0 to 100 with 0 indicating "No pain" and 100 indicating "Worst possible pain".	ITT and MITT Population - Baseline to 42 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Collaborators

The Cleveland Clinic

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

To obtain contact information for a study center near you, click here.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 4, 2006

Primary Completion (Actual)

April 12, 2016

Study Completion (Actual)

April 12, 2016

Study Registration Dates

First Submitted

June 28, 2006

First Submitted That Met QC Criteria

June 28, 2006

First Posted (Estimate)

June 29, 2006

Study Record Updates

Last Update Posted (Actual)

March 3, 2021

Last Update Submitted That Met QC Criteria

March 1, 2021

Last Verified

March 1, 2021

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

A3191172
2004-002441-13 (EudraCT Number)
PRECISION TRIAL (Other Identifier: Alias Study Number)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen (PRECISION)

A Randomized, Double Blind, Parallel-group Study Of Cardiovascular Safety In Osteoarthritis Or Rheumatoid Arthritis Patients With Or At High Risk For Cardiovascular Disease Comparing Celecoxib With Naproxen And Ibuprofen

Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Genders Eligible for Study

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Collaborators

Publications and helpful links

General Publications

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Estimate)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers