Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)

A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease


Lead Sponsor: Cogentus Pharmaceuticals

Source Cogentus Pharmaceuticals
Brief Summary

The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer disease, in the setting of concomitant aspirin therapy.

Antiplatelet therapy is an essential element of care for patients with atherothrombotic disease. Bleeding is a fundamental adverse effect of all antiplatelet drugs including aspirin, clopidogrel and dual antiplatelet regimens.

The gastrointestinal tract is the most common site of bleeding related to antiplatelet therapy, typically in connection with peptic ulcer disease. Recently published studies suggest the use of clopidogrel carries a gastrointestinal bleeding risk similar to that of aspirin or non-aspirin non-steroidal anti-inflammatory drugs. Patients taking any two of these drugs (clopidogrel, aspirin and/or non-aspirin NSAIDs) are exposed to an even higher risk of bleeding and ulcer disease.

Cogentus Pharmaceuticals is launching phase 3 trials of a novel combination product, CGT-2168, which has the potential to significantly reduce this problem and increase patient safety. CGT-2168 combines a standard dosage of clopidogrel and a gastroprotectant (omeprazole) in a once-daily pill that may reduce the likelihood of adverse gastrointestinal events.

Overall Status Terminated
Start Date December 2007
Completion Date November 2009
Primary Completion Date November 2009
Phase Phase 3
Study Type Interventional
Primary Outcome
Measure Time Frame
Composite of upper gastrointestinal clinical events, including gastroduodenal bleeding, symptomatic gastroduodenal ulcer, persistent pain with multiple gastric erosions, obstruction or perforation Anticipated minimum of 48 weeks, up to end of study
Secondary Outcome
Measure Time Frame
Composite of gastroduodenal bleeding, symptomatic gastroduodenal ulcer, obstruction or perforation Anticipated minimum of 48 weeks, up to end of study
Composite of gastroduodenal bleeding, obstruction or perforation Anticipated minimum of 48 weeks, up to end of study
Discontinuation of study medication attributed to gastrointestinal signs or symptoms Anticipated minimum of 48 weeks, up to end of study
Gastroesophageal reflux disease, as evidenced by symptomatic endoscopically-confirmed erosive esophagitis Anticipated minimum of 48 weeks, up to end of study
Dyspepsia, defined as an increase of at least ten points on the "pain intensity" component of the SODA instrument from baseline Anticipated minimum of 48 weeks, up to end of study
Occurrence of a cardiovascular event (cardiovascular death, nonfatal myocardial infarction, CABG or PCI, or confirmed ischemic stroke Anticipated minimum of 48 weeks, up to end of study
Enrollment 5000

Intervention Type: Drug

Intervention Name: CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin

Description: (CGT-2168 active and Comparator placebo, one capsule each daily; and enteric coated aspirin at daily dose level assigned by study physician)

Arm Group Label: 1

Intervention Type: Drug

Intervention Name: Plavix (clopidogrel 75 mg) and aspirin

Description: (CGT-2168 placebo and Comparator active, one capsule each daily; and enteric coated aspirin at daily dose level assigned by study physician)

Arm Group Label: 2



Inclusion Criteria:

- Patients in whom a requirement for clopidogrel therapy with concomitant aspirin is anticipated for at least the next 12 months. Specific conditions that may confer a need for long-term clopidogrel + aspirin therapy may include non-ST segment elevation acute coronary syndrome (unstable angina/non-Q-wave MI), ST segment elevation acute MI), or new placement of a coronary artery stent.

- For women of childbearing potential, negative pregnancy test prior to randomization and agreement to use effective method of birth control during the study.

- Able to provide written informed consent based on competent mental status.

Exclusion Criteria:

- Patients currently hospitalized for whom discharge is not anticipated within 48 hours of randomization.

- Requirement for current or chronic use of a proton pump inhibitor, H2 receptor blocker, sucralfate or misoprostol.

- Erosive esophagitis, esophageal or gastric variceal disease, or non-endoscopic gastric surgery. Patients with a history of GERD/erosive esophagitis or dyspepsia who do not currently require proton pump blockers will be eligible.

- Receipt of > 21 days of clopidogrel or another thienopyridine prior to randomization.

- Oral anticoagulation that cannot be safely discontinued for duration of study.

- Recent fibrinolytic therapy.

- Scheduled percutaneous coronary intervention (PCI). Patients may be enrolled upon completion of PCI.

- Recent (< 30 days prior to randomization) or scheduled coronary artery bypass graft (CABG) surgery.

- Cardiogenic shock at time of randomization, refractory ventricular arrhythmias, or congestive heart failure (NY Heart Association class IV).

- Active pathological bleeding or a history of hereditary or acquired hemostatic disorder.

- History of hemorrhagic stroke, intracranial neoplasm, arteriovenous malformation or aneurysm.

- Systemic corticosteroids except low-dose oral corticosteroids equivalent to prednisone < or equal to 5 mg/day.

- Allergy or contraindication to clopidogrel or other thienopyridine drugs, omeprazole or other proton pump inhibitor drugs, aspirin or salicylate derivatives, or other study drug ingredients.

- Treatment within 30 days prior to randomization with any investigational drug or device including investigational coronary artery stents or currently enrolled in another interventional drug or device study.

- Women who are pregnant or breastfeeding.

- Life expectancy less than 12 months.

- Laboratory abnormality at screening that is clinically significant or outside protocol-allowed limits, or any other condition that precludes participation in the study in the opinion of the Investigator.

Gender: All

Minimum Age: 21 Years

Maximum Age: N/A

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Pablo Lapuerta, MD Study Director Cogentus Pharmaceuticals
Alabama Clinical Research Institute, Inc. (ACRI) | Alexander City, Alabama, 35010, United States
Alabama Clinical Therapeutics, LLC | Birmingham, Alabama, 35126, United States
Cardio-Thoracic Surgeons P.C. | Birmingham, Alabama, 35213, United States
Birmingham Heart Clinic, PC | Birmingham, Alabama, 35235, United States
John F Simmons , MD PC | Geneva, Alabama, 36340, United States
Clinical Research Consultants, Inc. | Hoover, Alabama, 35216, United States
The Heart Center, PC | Huntsville, Alabama, 35801, United States
Mobile Heart Specialists, PC | Mobile, Alabama, 36608, United States
Advanced Cardiac Specialists | Mesa, Arizona, 85206, United States
Redpoint Research | Phoenix, Arizona, 85029, United States
Cardiovascular Consultants, Ltd. | Phoenix, Arizona, 85032, United States
Cochise Clinical Research | Sierra Vista, Arizona, 85635, United States
Paradigm Clinical Research, Inc. | Tucson, Arizona, 85705, United States
Tri-Lakes Research | Hot Springs, Arkansas, 71901, United States
Michael A. Frais, Cardiologist, P.A. | Hot Springs, Arkansas, 71913, United States
NEA-Clinic Cardiology | Jonesboro, Arkansas, 72401, United States
Searcy Medical Center | Searcy, Arkansas, 72143, United States
Cardiology Consultants of Orange County | Anaheim, California, 92801, United States
Chest and Critical Care Consultants, A Medical Group | Anaheim, California, 92801, United States
Clinical Solutions Advantage | Buena park, California, 90620, United States
Turns Institute for Clinical Research | Castro Valley, California, 94546, United States
Escondido Cardiology Associates | Escondido, California, 92025, United States
Accurate Clinical Trials, Inc. | Laguna Hills, California, 92653, United States
Therapeutic Research Institute of Orange County | Laguna Hills, California, 92653, United States
Kirtik Thaker MD | Lakewood, California, 90712, United States
Los Angeles Cardiology Associates | Los Angeles, California, 90017, United States
Merced Heart Associates | Merced, California, 95348, United States
Mission Internal Medical Group | Mission Viejo, California, 92691, United States
Altos Cardiovascular Associates | Mountain View, California, 94040, United States
Kenneth W. Carr, MD, Cardiology | Oceanside, California, 92056, United States
Rancho CucamongaClinical Trials | Rancho Cucamonga, California, 91703, United States
Inland Heart and Vascular Medical Associates | San Bernardino, California, 92404, United States
Ritchken and First | San Diego, California, 92117, United States
Rider Research Group | San Francisco, California, 94117, United States
Richard Levy, MD. | San Francisco, California, 94118, United States
Kaiser Permanente | San Jose, California, 95119, United States
Medical Helping Hands Research | Santa Ana, California, 92704, United States
Pacific Heart Institute | Santa Monica, California, 90404, United States
Radiant Research | Santa Rosa, California, 95405, United States
Harbor- UCLA Medical Center | Torrance, California, 90509, United States
Ventura Cardiology Consultants Medical Group, Inc. | Ventura, California, 93003, United States
Colorado Springs Health Partners | Colorado Springs, Colorado, 80907, United States
Connecticut Clinical Research | Bridgeport, Connecticut, 06606, United States
Hartford Hospital | Hartford, Connecticut, 06102, United States
Alfieri Cardiology, PA | Newark, Delaware, 19713, United States
Washington V.A. Medical Center | Washington, District of Columbia, 20422, United States
Oscar R. Guerra, MD PA | Coral Gables, Florida, 33134, United States
Deerfield Beach Cardiology Associates | Deerfield Beach, Florida, 33442, United States
Dr Jules Cohen | Hallandale, Florida, 33009, United States
Empire International Research | Hialeah, Florida, 33012, United States
Cardiovascular Consultants of South Florida | Hollywood, Florida, 33021, United States
Jacksonville Heart Center | Jacksonville, Florida, 32207, United States
Jacksonville Center for Clinical Research | Jacksonville, Florida, 32216, United States
Jacksonville Heart Center | Jacksonville, Florida, 32250, United States
CVMS Resesarch Institute, LLC | Jupiter, Florida, 33458, United States
Watson Clinic Center for Research | Lakeland, Florida, 33805, United States
Alpha Medical Research, LLC | Melbourne, Florida, 32901, United States
Empire International Research | Miami, Florida, 33125, United States
Suncoast Research Group, LLC | Miami, Florida, 33144, United States
Cardiovascular Research Center of South Florida | Miami, Florida, 33173, United States
Research Center Phase I-IV of Florida Corp. | Miami, Florida, 33175, United States
Empire International Research | Miami, Florida, 33186, United States
Bert Fish Medical Center | New Smyrna Beach, Florida, 32168, United States
Central Florida Cardiology Group | Orlando, Florida, 32803, United States
Cardiology Assocaites of Orlando d/b/a Orlando Heart Center | Orlando, Florida, 32806, United States
Sunset Point Medical Associates | Palm Harbor, Florida, 34684, United States
Berma Research Group | Plantation, Florida, 33317, United States
Charlotte Heart Group Research Center | Port Charlotte, Florida, 33952, United States
Suncoast Cardiovascular Research | St. Petersburg, Florida, 33701, United States
The Heart and Vascular Institute of Florida | St. Petersburg, Florida, 33709, United States
G&G Research Baker-Tombul Cardiology | Vero Beach, Florida, 32960, United States
Carlos Levy, D.O. | Weston, Florida, 33326, United States
Piedmont Hospital | Atlanta, Georgia, 30309, United States
Primary Care Specialists, LLC/ ECAST CT | Atlanta, Georgia, 30312, United States
Executive Health and Research Associates, Inc. | Atlanta, Georgia, 30342, United States
Southeast Regional Research Group | Columbus, Georgia, 31904, United States
Georgia Heart Specialists, LLC | Covington, Georgia, 30014, United States
Ialum Clinical Research Center, LLC | Decatur, Georgia, 30032, United States
Ialum Clinical Research Center | Decatur, Georgia, 30032, United States
Ialum Clinical Research Center | Decatur, Georgia, 30035, United States
Southeast Regional Research Group | Savannah, Georgia, 31406, United States
Medsouth Primary CareStockbridge | Stockbridge, Georgia, 30281, United States
South Suburban Health Professional Group, PC | Flossmoor, Illinois, 60422, United States
Consultants in Cardiovascular Medicine | Melrose Park, Illinois, 60160, United States
Methodist Medical Center of Illinois | Peoria, Illinois, 61606, United States
Community Clinical Research Center | Anderson, Indiana, 46011, United States
American Health Network | Avon, Indiana, 46123, United States
Indiana Medical Research | Elkhart, Indiana, 46514, United States
Welborn Clinic | Evansville, Indiana, 47713, United States
Indiana Heart Physicians | Indianapolis, Indiana, 46237, United States
Midwest Cardiovascular Research Foundation | Davenport, Iowa, 52803, United States
Northeast Iowa Medical Education Foundation | Waterloo, Iowa, 50702, United States
Hutchinson Clinic, P.A. | Hutchinson, Kansas, 67502, United States
Venture Resource Group, Inc. | Mission, Kansas, 66202, United States
Midwest Cardiology Assocaites | Overland Park, Kansas, 66209, United States
Cumberland Cardiology | Ashland, Kentucky, 41101, United States
Trover Health System | Madisonville, Kentucky, 42431, United States
Owensboro Heart and Vascular | Owensboro, Kentucky, 42303, United States
Dolby Research, LLC | Baton Rouge, Louisiana, 33437, United States
Cardiovascular Institute of the South | Houma, Louisiana, 70301, United States
Heart Clinic of Louisiana Clinical Research, LLC. | Marrero, Louisiana, 70072, United States
Maine Research Associates | Auburn, Maine, 04210, United States
Cardiovascular Consultants of Maine, PA | Scarborough, Maine, 04074, United States
Maine Cardiology Associates | South Portland, Maine, 04106, United States
Good Samaritan Hospital (Medstar Health) | Baltimore, Maryland, 21239, United States
eCast Corporation | Greenbelt, Maryland, 20770, United States
Atlantic Cardiology Associates, P.A | Salisbury, Maryland, 21801, United States
Peninsula Cardiology Associates | Salisbury, Maryland, 21804, United States
Pentucket Medical Associates | Haverhill, Massachusetts, 01830, United States
Charles River Medical Associates | Natick, Massachusetts, 01760, United States
Michigan Cardiovascular Institute | Bay City, Michigan, 48708, United States
Apex Medical Research, AMR, Inc. | Flint, Michigan, 48504, United States
Borgess Research Institute | Kalamazoo, Michigan, 49048, United States
Michigan Cardiovascular Institute | Midland, Michigan, 48670, United States
Michigan Cardiovascular Institute | Saginaw, Michigan, 48601, United States
Covenant Medical Center, Inc. | Saginaw, Michigan, 48602, United States
Academic Heart and Vascular PLLC | St. Clair Shores, Michigan, 48081, United States
Oakland Medical Center | Troy, Michigan, 48085, United States
Waterford Medical Assoc. P.C. | Waterford, Michigan, 48328, United States
Michigan Heart, PC | Ypsilanti, Michigan, 48106, United States
Duluth Clinic / Saint Marys Medical Center | Duluth, Minnesota, 55805, United States
University of Minnesota | Minneapolis, Minnesota, 55455, United States
Regions Hospital | St. Paul, Minnesota, 55101, United States
New Coast Cardiology Center, PLLC | Gulfport, Mississippi, 39503, United States
PPS Clinical Research, STL, LLC | Chesterfield, Missouri, 63017, United States
Kansas City VA Medical Center | Kansas City, Missouri, 64128, United States
Cardiology Diagnostics, Ltd. | St. Louis, Missouri, 63122, United States
Glacier View Cardiology | Kalispell, Montana, 59901, United States
Saint Patrick Hospital- International Heart Institute of Montana | Missoula, Montana, 59802, United States
The Creighton Cardiac Center | Omaha, Nebraska, 68131, United States
Alegent Health Clinic Heart and Vascular Specialist | Papillion, Nebraska, 68046, United States
Nevada Cardiology Associates | Las Vegas, Nevada, 89128, United States
Lahey Cardiology @ the Medical Center | Nashua, New Hampshire, 03060, United States
Associated Cardiovascular Consultants | Cherry Hill, New Jersey, 08034, United States
Cardiovascular Associates of the Delaware Valley, P.A. | Elmer, New Jersey, 08318, United States
Cardiovascular Associates of the Delaware Valley, P.A. | Haddon Heights, New Jersey, 08035, United States
Cardiovascular Associates of the Delaware Valley, P.A. | Sewell, New Jersey, 08080, United States
Physicans Research Center, LLC | Toms River, New Jersey, 08755, United States
Capital Cardiology Associates | Albany, New York, 12211, United States
Cardiac Care and Vascular Medicine, Albert Einstein College of Medicine | Bronx, New York, 10469, United States
Hudson Valley Cardiology Group, P.C. | Cortlandt Manor, New York, 10567, United States
Cardiology Associates, P.C. | Johnson City, New York, 13790, United States
Long Island Heart Associates | Mineola, New York, 11501, United States
Slocum-Dickson Medical Group, PLLC | New Hartford, New York, 13413, United States
Sound Shore Cardiology, P.C. | New Rochelle, New York, 10801, United States
New York Cardiovascular Associate | New York, New York, 10001, United States
St. Luke's- Roosevelt Hospital | New York, New York, 10025, United States
Rochester General Hospital | Rochester, New York, 14621, United States
Saratoga Cardiology Assoc, PC | Saratoga Springs, New York, 12866, United States
Westchester Cardiology Associates | Scarsdale, New York, 10583, United States
Good Samaritan Hospital | Suffern, New York, 10901, United States
Cardiology, PC | Syracuse, New York, 13210, United States
SUNY Upstate Medical University | Syracuse, New York, 13210, United States
Capital Cardiology Associates | Troy, New York, 12180, United States
Buffalo Cardiology and Pulmonary Associates | Williamsville, New York, 14221, United States
Mark J. Kozinn, MD | Williamsville, New York, 14221, United States
Clinical Study Center of Asheville, LLC | Asheville, North Carolina, 28803, United States
Kernodle Clinic, Inc. | Burlington, North Carolina, 27215, United States
Metrolina Medical Research | Charlotte, North Carolina, 28209, United States
Diversified Research | Durham, North Carolina, 27704, United States
Cumberland Research Associates, LLC | Fayetteville, North Carolina, 28304, United States
Cardiovascular Care of Northern Carolina | Oxford, North Carolina, 27565, United States
St. Alexius Medical Center | Bismarck, North Dakota, 58501, United States
Altru Health Systems | Grand Forks, North Dakota, 58201, United States
Trinity Health | Minot, North Dakota, 58701, United States
George G. Ellis, Jr. M.D., Inc. | Boardman, Ohio, 44512, United States
Cardiovascular Research Institute, LLC | Canton, Ohio, 44710, United States
Comprehensive Cardiology Consultants, Inc. | Cincinnati, Ohio, 45236, United States
Midwest Cardiology Research Foundation | Columbus, Ohio, 43214, United States
Prestige Clinical Research | Franklin, Ohio, 45005, United States
St. Vincent Mercy Medical Center | Toledo, Ohio, 43608, United States
Cardiology Associates of SE Ohio, Inc | Zanesville, Ohio, 43701, United States
Physicans Research, Inc. | Zanesville, Ohio, 43701, United States
Bluestem Cardiology Research Dept. | Bartlesville, Oklahoma, 74006, United States
Oklahoma Cardiovascular Research Group | Oklahoma City, Oklahoma, 73109, United States
Aquilo Research | Yukon, Oklahoma, 73099, United States
Bend Memorial Clinic | Bend, Oregon, 97701, United States
Hillsboro Cardiology, PC | Hillsboro, Oregon, 97123, United States
Legacy Clinical Research | Portland, Oregon, 97210, United States
Abington Medical Specialists | Abington, Pennsylvania, 19001, United States
Tri-State Medical Group | Beaver, Pennsylvania, 15009, United States
Heritage Cardiology Association | Camp Hill, Pennsylvania, 17011, United States
Premier Heart Specialists | Easton, Pennsylvania, 18042, United States
Heart Specialists of Lancaster | Ephrata, Pennsylvania, 17522, United States
Penn State Hershey Medical Center | Hershey, Pennsylvania, 17033, United States
Pennsylvania Heart and Vascular Group, P.C. | Jenkintown, Pennsylvania, 19046, United States
Comprehensive Cardiology Consultants | Langhorne, Pennsylvania, 19047, United States
Sewickley Valley Medical Group Cardiology | Leetsdale, Pennsylvania, 15056, United States
Cardiology Consultants of Philadelphia | Norristown, Pennsylvania, 19401, United States
Hospital of the University of Pennsylvania Cardiology Department | Philadelphia, Pennsylvania, 19104, United States
Cardiology Consultants of Philadelphia | Philadelphia, Pennsylvania, 19111, United States
Albert Einstein Medical Center | Philadelphia, Pennsylvania, 19141, United States
Cardiology Consultants of Philadelphia | Philadelphia, Pennsylvania, 19148, United States
VA Pittsburgh Healthcare System | Pittsburgh, Pennsylvania, 15240, United States
Advanced Cardiology Specialists | Scranton, Pennsylvania, 18501, United States
Elite Medical Research, Inc. | Sellersville, Pennsylvania, 18960, United States
Cardiology Consultants of Philadelphia | Upland, Pennsylvania, 19013, United States
West Chester Cardiology, PC | West Chester, Pennsylvania, 19380, United States
Berks Cardiology, Ltd. | Wyomissing, Pennsylvania, 19610, United States
Cardiology Consultants of Philadelphia | Yardley, Pennsylvania, 19067, United States
New England Center for Clinical Research&comma; Inc | Cranston, Rhode Island, 02920, United States
Rhode Island Hospital Cardiology | Providence, Rhode Island, 02903, United States
Cardiology Specialists | Westerly, Rhode Island, 02891, United States
Palmetto Clinical Research | Summerville, South Carolina, 29485, United States
McMinn Medical Group (DBA: Athens Medical Group) | Athens, Tennessee, 37303, United States
Verzosa & Ungab Internal Medicine Associates | Bartlett, Tennessee, 38134, United States
Middle Tennessee Clinical Research | Fayetteville, Tennessee, 37334, United States
Research Associates of Jackson and Apex Cardiology | Jackson, Tennessee, 38301, United States
Tri-State Cardiology | Johnson City, Tennessee, 37601, United States
Memphis Internal Medicine | Memphis, Tennessee, 38119, United States
Goodlife Medical Center | Memphis, Tennessee, 38120, United States
Heart and Vascular Clinic | Nashville, Tennessee, 37203, United States
Family Health Care Assoc. | Arlington, Texas, 76013, United States
Southeast Texas Clinical Research Center | Beaumont, Texas, 77702, United States
Trinity Hypertension and Diagnostic Res. | Carrollton, Texas, 75006, United States
VA Medical Center | Dallas, Texas, 75216, United States
U.T. Southwestern | Dallas, Texas, 75390, United States
Amir Malik Research | Fort Worth, Texas, 76104, United States
The University of Texas Medical Branch at Galveston | Galveston, Texas, 77555-0553, United States
East Texas Cardiology PA | Houston, Texas, 77002, United States
Office of Amer Zaheer, MD | Houston, Texas, 77004, United States
Office of Salim Gopalani, MD | Houston, Texas, 77008, United States
Comprehensive Heart Care, PA | Houston, Texas, 77024, United States
Century Clinical Research | Houston, Texas, 77036, United States
Office of Mizra Basith Baig, MD | Houston, Texas, 77055, United States
Covenant Cardiology Associates | Lubbock, Texas, 79410, United States
South Texas Institutes of Health | Mcallen, Texas, 78572, United States
Texas Regional Heart Center d/b/a Legacy Heart Center | Plano, Texas, 75024, United States
Heart & Vascular Institute of Texas | San Antonio, Texas, 78217, United States
Cardiology Clinic of San Antonio | San Antonio, Texas, 78229, United States
South Texas Cardiovascular Consultants | San Antonio, Texas, 78229, United States
IMED Research, PA | San Antonio, Texas, 78258, United States
Southwest Health Associate, PA | Sugar Land, Texas, 77478, United States
Office of Dwayne O. Williams, MD | Sugarland, Texas, 77479, United States
Kings Daughters Clinic | Temple, Texas, 76502, United States
Victoria Heart and Vascular Center | Victoria, Texas, 77901, United States
Cardiology Consultants of Danville | Danville, Virginia, 24541, United States
Triad Research Institute | Galax, Virginia, 24333, United States
Virginia Cardiovascular Specialists | Richmond, Virginia, 23226, United States
Winchester Medical Center/ Clinical Research Department | Winchester, Virginia, 22601, United States
Daniel W. Gottlieb, MD, PS | Burien, Washington, 98166, United States
Heart Clinic Northwest | Spokane, Washington, 99204, United States
Inland Cardiology Assocaites | Spokane, Washington, 99204, United States
Franciscan Health System dba FHS Research Center | Tacoma, Washington, 98405, United States
Parkersburg Cardiology Associates | Parkersburg, West Virginia, 26101, United States
Wisconsin Heart, S.C. | Madison, Wisconsin, 53715, United States
Heart Care Associates, LLC | Milwaukee, Wisconsin, 53215, United States
The Canberra Hospital | Garran, Australian Capital Territory, 2605, Australia
Coffs Harbour Cardiology | Coffs Harbour, New South Wales, 2450, Australia
Cardiac Research Institute | Eastwood, New South Wales, 2122, Australia
Wesley research institute | Auchenflower, Queensland, 4066, Australia
Cairns Base Hospital | Cairns, Queensland, 4870, Australia
Royal Brisbane and Women's Hospital | Herston, Queensland, 4029, Australia
Royal Hobart Hospital | Hobart, Tasmania, 7001, Australia
Launceston General Hospital | Launceston, Tasmania, 7250, Australia
Northern Hospital | Epping, Victoria, 3076, Australia
St.Vincent's Hospital (Melb) | Fitzroy, Victoria, 3065, Australia
Geelong Hospital- Barwon Health | Geelong, Victoria, 3220, Australia
Fremantle Hospital | Fremantle, Western Australia, 6160, Australia
Multiprofile Hospital for Active Treatment "Sveta Ekaterina", 1st Department of Internal Diseases | Dimitrovgrad, Bulgaria
Multiprofile Hospital for Active Treatment "Dr. Georgi Stranski, Clinic of Cardiology | Pleven, Bulgaria
Multiprofile Hospital for Active Treatment ''Sveti Georgi'', Cardiology Clinic | Plovdiv, Bulgaria
Multiprofile Hospital for Active Treatment ''Sveti Panteleymon'', 2nd Department. of Internal Diseases - Intensive Cardiology Unit | Plovdiv, Bulgaria
Multiprofile Hospital for Active Treatment - Ruse, 4th Department of Internal Diseases | Rousse, Bulgaria
4th Multiprofile Hospital for Active Treatment | Sofia, Bulgaria
Military Medical Academy, Clinic of Cardiology and Intensive Care | Sofia, Bulgaria
Multiprofile Hospital for Active Treatment and Emergency Medicine "Pirogov". Cardiology Clinic | Sofia, Bulgaria
National Heart Hospital Department of Cardiology | Sofia, Bulgaria
National Multiprofile Transport Hospital "Tsar Boris III, Cardiology Clinic | Sofia, Bulgaria
Tokuda Hospital Department of Cardiology | Sofia, Bulgaria
University Multiprofile Hospital for Active Treatment ''Tsaritsa Ioanna'' - ISUL, Cardiology Clinic | Sofia, Bulgaria
Multiprofile Hospital for Active Treatment "Sveta Marina", Clinic of Internal Diseases - 2nd Internal Department | Varna, Bulgaria
Dr. Tsui | Maple Ridge, British Columbia, V2X 5Z6, Canada
Fraser Clinical Trials Inc and Royal Columbian Hospital | New Westminster, British Columbia, V3L3W4, Canada
Vancouver General Hospital | Vancouver, British Columbia, V5Z 1M9, Canada
Victoria Heart Institute Foundation | Victoria, British Columbia, V8R4R2, Canada
Health Sciences Centre | Winnipeg, Manitoba, R3A1R9, Canada
South East Regional Health Authority | Moncton, New Brunswick, E1C4B7, Canada
Commonwealth Medical Clinic | Mount Pearl, Newfoundland and Labrador, A1N1W7, Canada
Cambridge Cardiac Care Centre | Cambridge, Ontario, NIR-6V6, Canada
Mississauga Clinical Research Center | Mississauga, Ontario, L5B2P7, Canada
Dr. George Zimakas | Niagara Falls, Ontario, L2G5X7, Canada
Dr. James Y. Cha | Oshawa, Ontario, L1J2K1, Canada
Curans Health Center | Thunder Bay, Ontario, P7R2Z3, Canada
Toronto East Cardiology Associates Inc. | Toronto, Ontario, M4C-1N2, Canada
Recherches Cliniques Theradev | Granby, Quebec, J2G8Z9, Canada
ViaCar Recherche Clinique Inc. | Greenfield Park, Quebec, J4N1L6, Canada
ViaCar Recherche Clinique Inc | Longueuil, Quebec, J4N1L6, Canada
Hospitalier de l'Universite de Montreal Hotel Dieu | Montreal, Quebec, H2W 1T8, Canada
Sacre-Coeur Hospital | Montreal, Quebec, H4J1C5, Canada
Centre de Sante et de services sociaux du nord de lanaudiere/CHRDL | St. Charles-Borromee, Quebec, J6E6J2, Canada
Centre Hospitalier Beauce-Etchemin | St. George, Quebec, G5Y5B7, Canada
Clinique de Cardiologie de Trois-Rivieres | Trois Rivieres, Quebec, G8Z 3R9, Canada
Cardiology and Research | Westmount, Quebec, H3Z2M6, Canada
Centre Hospitalier Universitaire de Quebec (CHOQ) Hotel Dieu de Quebec | Quebec, G1R2J6, Canada
Laval Hospital | Quebec, G1V4G5, Canada
Clinica Antofagasta | Antofagasta, Chile
Corporación de Beneficencia Osorno | Osorno, Chile
Hospital Regional de Punta Arenas Dr. Lautaro Navarro | Punta Arenas, Chile
Complejo Asistencial Dr.Sótero del Río | Santiago, 8207257, Chile
Hospital del Salvador | Santiago, Chile
Instituto Nacional del Tórax | Santiago, Chile
Centro de Estudios Cardiovascular | Temuco, Chile
Clínica Reñaca | Viña del Mar, Chile
Hospital Dr. Gustavo Fricke | Viña del Mar, Chile
Hospital Naval Almirante Neff | Viña del Mar, Chile
Nemocnice ve Frydku-Mistku | Frydek-Mistek, 738 18, Czech Republic
Fakultni nemocnice Hradec Kralove | Hradec Kralove, 500 05, Czech Republic
Krajska nemocnice Liberec, a. s. | Liberec, 460 63, Czech Republic
Litomyslska nemocnice a. s. | Litomysl, 570 14, Czech Republic
Kardiologicka a angiologicka ambulance | Ostrava Vítkovice, 703 00, Czech Republic
Kardiologická ambulance | Ostrava, 702 00, Czech Republic
Pardubicka krajska nemocnice, a.s. | Pardubice, 532 03, Czech Republic
II.interni klinika kardiologie a angiologie 1. LF UK a VFN v Praze | Praha 2, 12808, Czech Republic
Klinika kardiologie Institut klinické a experimentální medicíny | Praha 4, 140 21, Czech Republic
Krajská nemocnice T. Bati a.s. | Zlín, 762 75, Czech Republic
Nemocnice Znojmo, p.o. | Znojmo, 669 02, Czech Republic
Centre Hospitalier d'Albi | Albi, 81000, France
Centre de Cardiologie CHRU Dijon | Dijon Cedex, 21079, France
Clinique Pasteur | Essey les Nancy Cedex, 54270, France
CHRU de Lille Hôpital Cardiologique | Lille Cedex, 59037, France
Hôpital La Timone-Adultes | Marseille, 13385, France
La Pitié Salpétrière Institut de Cardiologie | Paris Cedex 13, 75651, France
Hôpital Lariboisière | Paris, 75010, France
Centre Hospitalier Intercommunal du Val d'Ariège | St Jean de Verges, 09000, France
Centre Hospitalier Rangueil Larrey | Toulouse Cedex 4, 31403, France
Universitatsklinikum Berlin Campus Charite Mitte Med Klinik Kardiologie und Angiologie | Berlin, 10117, Germany
Vivantes Clinic Neuköln Berlin | Berlin, 12351, Germany
Vivantes Humbolt Klinikum | Berlin, 13509, Germany
Praxis Dr. med. Boscher | Biberach, 88400, Germany
St. Josef-Hospital Medizinische Klinik II, Kardiologie | Bochum, 44791, Germany
Dr. THomas Klingenheben | Bonn-Lengsdorf, 53127, Germany
St.-Marien-Hospital Bonn | Bonn, 53115, Germany
Städtisches Klinikum Brandenburg GmbH | Brandenburg, 14770, Germany
MVZ am Küchwald GmbH | Chemnitz, 09113, Germany
Gemeinschaftspraxis Innere Medizin und Kardiologie | Dinslaken, 46535, Germany
St.-Johannes-Hospital Dortmund | Dortmund, 44137, Germany
Zentrum für klinische Prüfungen in der Facharztzentrum Dresden Neustadt GbR | Dresden, 1099, Germany
Practice of Cardiology | Erfurt, 990804, Germany
Elisabeth.Krankenhaus | Essen, 45138, Germany
Asklepios Klinik St.Georg | Hamburg, 20099, Germany
Asklepios Klinik Barmbek | Hamburg, 22291, Germany
Universitäres Herz-und Gefäßzentrum Hamburg" | Hamburg, 22527, Germany
Kardiologische Praxis Hamburg Altona | Hamburg, 22765, Germany
Klinikum Region Hannover Krankenhaus Nordstadt | Hannover, 30167, Germany
Kardiologische Gemeinschaftspraxis | Hartmannsdorf, 09232, Germany
SRH Klinikum Karlsbad-Langensteinbach | Karlsbad, 76307, Germany
Kliniken der Stadt Köln, Köln Merheim | Koln, 53109, Germany
Herzzentrum Lahr | Lahr, 77933, Germany
Kardiologische Gemeinschaftpraxis | Leipzig, 04103, Germany
Universität Leipzig - Herzzentrum | Leipzig, 04289, Germany
Praxis für Innere Medizin, Gastroenterologie | Ludwigshafen, 67067, Germany
Universitätsklinikum Lübeck | Lübeck, 23538, Germany
Gemeinschaftspraxis | Lüneburg, 21339, Germany
Klinikum der Johannes-Gutenberg-Universität | Mainz, 55131, Germany
Gemeinschaftspraxis | Mannheim, 68165, Germany
Klinikum Mannheim GmbH, Universaitatskinikum | Mannheim, 68167, Germany
Kardiologische Praxis | Markkleeberg, 04416, Germany
Asklepios Klinik Melsungen | Melsungen, 34212, Germany
Kilniken Maria Hilf GmbH Krankenhaus St. Franziskus | Mönchengladbach, 41063, Germany
Internist/Kardiologe/Angiologe | Mühldorf a.d. Inn, 84453, Germany
Kardiologische Gemeinschaftspraxis | Nienburg, 31582, Germany
Klinikum Pirna GmbH | Pirna, 01796, Germany
Universitätsklinik Regensburg | Regensburg, 93053, Germany
Krankenhaus Reinbek St. Adolf-Stift | Reinbek, 21465, Germany
Kardiologische Gemeinschaftspraxis | Riesa, 01589, Germany
Internistische Praxis | Rottweil, 78628, Germany
Zentrum für Prävention und Rehabilation | Siegen, 57072, Germany
Marienkrankenhaus Soest | Soest, 59494, Germany
Praxisgemeinschaft Stuhr-Brinkum | Stuhr, 28816, Germany
Medizinische Universitätsklinik | Tubingen, 72076, Germany
Josephs-Hospital Warendorf | Warendorf, 48231, Germany
Kardiologische Praxis | Wermsdorf, 04779, Germany
Dr. Andreas Schreckenberg | Weyhe-Leeste, 28844, Germany
ForschungsZentrum Ruhr | Witten, 58455, Germany
Helios Klinikum Wuppertal | Wuppertal, 42117, Germany
Bajai Kórház | Baja, H-6500, Hungary
Budai Irgalmasrendi Kórház | Budapest, H-1027, Hungary
Fővárosi Önkormányzat Károlyi Sándor Kórház és Rendelőintézet | Budapest, H-1041, Hungary
Fovarosi Onkormanyzat Egyesitett Szent Istvan es Szent Laszlo Korhaz - Rendelointezet | Budapest, H-1096, Hungary
Városi Önkormányzat Kórház-Rendelőintézet | Kalocsa, H-6300, Hungary
Szabolcs-Szatmár-Bereg Megyei Önkormányzat Jósa András Oktató Kórház | Nyíregyháza, H-4400, Hungary
Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház | Toszegi, H-5004, Hungary
Jávorszky Ödön Kórház | Vác, H-2600, Hungary
Zala Megyei Kórház | Zalaegerszeg, H-8900, Hungary
Ospedali Riuniti di bergamo | Bergamo, 24128, Italy
Azienda Ospedaliera della Provincia di Lodi Presidio Ospedaliero di Codogno | Codogno (Lodi), 26845, Italy
Azienda Ospedaliera Universitaria San Martino-Dipartimento di Medicina Interna e Specialità Mediche | Genova, 16132, Italy
Azienda Ospeedaliera Carlo Poma | Mantova, 46100, Italy
Azienda Ospedaliera Maggiore Della Carita' Di Novara | Novara, 28100, Italy
Istituto Clinico Humanitas | Rozzano (Milano), 20089, Italy
Hospital "Valentín Gómez Farías" | Guadalajara, Jalisco, 44600, Mexico
Cardioarritmias e Investigación, S.C. | San Luis Potosi, San Lusi Potosi, 78200, Mexico
Hospital Cardiológica Aguascalientes | Aguascalientes, 20230, Mexico
Hospital de Jesus | D. F., cp 06090, Mexico
Cardioprevent | Durango, C. P 34080, Mexico
Hospital Angeles de Puebla | Puebla, 72190`, Mexico
Hospital General de Puebla | Puebla, 72490, Mexico
Instituto de Corazón de Querétaro, S.A. de C.V. | Queretaro, 76178, Mexico
Hospital Central "Dr. Ignacio Morones Prieto" | San Luis Potosi, 78240, Mexico
Oddział Kardiologii z Zakładem Diagnostyki Kardiologicznej, Samodzielny Publiczny Zakład Opieki Zdrowotnej, Wojewódzki Szpital im. dr J. Biziela, | Bydgoszcz, 85-168, Poland
NZOZ "Medicus" Jacek Kubica | Bydgoszcz, 85-435, Poland
Wojewódzki Szpital Meijski im. Biziela, Oddział Kardiologii - SPZOZ | Bydgoszcz, 85-826, Poland
Oddział Chorób Wewnętrzych i Kardiologii , ZOZ w Debicy | Dębica, 39-200, Poland
Zakład Opieki Zdrowotnej Trójmiejskie Centrum Medyczne Sp. z o.o | Gdańsk, 80-437, Poland
Gabinet Kardiologiczny Medipuls | Gdynia, 81-423, Poland
Gabinet Kardiologiczno-Internistyczny | Gdynia, 81-472, Poland
Centrum Leczenia Chorób Cywilizacyjnych Oddz. Gdynia filla Fikakowo | Gdynia, 81-572, Poland
NZOZ Medicus, Poradnia Kardiologiczna | Gliwice, 44-100, Poland
Oddział Kardiologii i INK, SPZOZ nr 1 | Gliwice, 44-100, Poland
Mazowieckie Centrum Badań Klinicznych Iwona Czajkowska, Monika Śmietańska s.c. | Grodzisk Mazowiecki, 05-825, Poland
Publiczny Specjalistyczny Zaklad Opieki Zdrowotnej Oddzial Kardiologiczny | Inowroclaw, 88-100, Poland
Oddział Chorób Wewnętrznych i Farmakologii Klinicznej Samodzielny Publiczny Centralny Szpital Kliniczny im. Prof. Kornela Gibińskiego Śląskiego Uniwersytetu Medycznego w Katowicach | Katowice, 40-752, Poland
Szpital Specjalistyczny w Kościerzynie, Oddział Kardiologii | Kościerzyna, 83-400, Poland
Oddział Kardiologii, Szpital Specjalistyczny im. J. Dietla | Krakow, 31-121, Poland
"Klinika Choroby Wieńcowej Instytut Kardiologii, Collegium Medicum Uniwerytet Jagielloński | Krakow, 31-202, Poland
Oddzial Chorób Wewnętrznych III Szpital Specjalistyczny im.Stefana Zeromskiego, SPZOZ w Krakowie | Kraków, 31-913, Poland
Niepubliczny Zakład Opieki Zdrowotnej Specjalista Sp. z o.o. | Kutno, 99-300, Poland
Poradnia Kardiologiczna, Oddział Chorob Wewnetrznych Szpital Powiatowy w Limanowej | Limanowa, 34-600, Poland
Oddział Internistyczno-Kardiologiczny Samodzielny Publiczny Zakład Opieki Zdrowotnej | Lubartów, 21-100, Poland
"Oddzial Chorob Wewnetrznych i Kardiologii, Szpital Powiatowy im.Edmunda Biernackiego | Mielec, 39-300, Poland
Oddział Kardiologii, Nowa Sól | Nowa Sól, 67-100, Poland
ZOZ w Oławie, Oddział Chorób Wewnętrznych | Olawa, 55-200, Poland
"Oddział Kardiologiczno-Internistyczny | Olsztyn, 10-045, Poland
"Oddział Kardiologiczny Publiczny Samodzielny ZOZ Wojewódzkie Centrum Medyczne | Opole, 45-418, Poland
Specjalistyczny Zakład Opieki Zdrowotnej Poradnia lekarzy specjalistów "Jantar" | Ostrów Wielkopolski, 63-400, Poland
II Oddział Wewnętrzny Samodzielny Publiczny Zakład Opieki Zdrowotnej | Pabianice, 95-200, Poland
"Samodzielny Szpital Wojewódzki im. Mikołaja Kopernika, Oddział Kardiologiczny | Piotrków Trybunalski, 97-300, Poland
Medyczne Centrum Hetmańska, Indywiualna Specjalistyczna Praktyka Lekarska, Dr n. med. Piotr Leszczyński | Poznań, 60-218, Poland
Specjalistyczne Centrum Diagnostyczno-Lecznicze Bamberski Dwór | Poznań, 60-539, Poland
Oddział Wewnetrzny I, Szpital Kolejowy im. dr med. Włodzimierza Roeslera | Pruszków, 05-800, Poland
Samodzileny Publiczny Zakład Opieki Zdrowotnej w Puławach, Szpital Specjalistyczny | Puławy, 24-100, Poland
Wojewódzki Szpital Zespolony, Oddział Kardiologiczny | Płock, 09-400, Poland
Specjalistyczna Przychodnia Lekarska "Medikard" | Płock, 09-402, Poland
Zakład Hemodynamiki, Wojewódzki Szpital Specjalistyczny | Radom, 26-617, Poland
"Oddział Kardiologii z Pododdziałem Ostrych Zespołów Wieńcowych i z Ośrodkiem Implantacji Rozruszników Serca, | Rzeszów, 35-301, Poland
Oddział Kardiologii, SP ZZOZ Sandomierz | Sandomierz, 27-600, Poland
Oddział Kardiologiczny Wojewódzki Szpital Specjalistyczy w Siedlcach | Siedlce, 08-110, Poland
Oddział Kardiologii Samodzielny Publiczny Zakład Opieki Zdrowotnej w Sieradzu im. Kardynała Stefana Wyszyńskiego | Sieradz, 98-200, Poland
"Oddział Kardiologii, Wojewódzki Szpital Zespolony w Skierniewicach, " | Skierniewice, 96-100, Poland
NZOZ Przychodnia Zadebie, Przychodnia Kardiologiczna | Skierniewice, 96-100, Poland
"Oddział Kardiologii Inwazyjnej i Angiologii z Pr. Hemodynamiki | Stalowa Wola, 37-450, Poland
Szpital Specjalistyczny Św.Jana, Oddział Kardiologii, | Starogard Gdański, 83-200, Poland
Indywidualna Specjalistyczna Praktyka Lekarska | Szczecin, 71-531, Poland
Poradnia Kardiologiczna | Tarnów, 33-100, Poland
Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny-Cardiology | Tarnów, 33-100, Poland
Niepubliczny Zakład Opieki Zdrowotnej "Nasz Lekarz", Praktyka Grupowa Lekarzy Rodzinnych z Przychodnią Specjalistyczną | Torun, 87 100, Poland
Oddział Kardiologii Wojewódzki Szpital Zespolony | Toruń, 87-100, Poland
Oddział Kardiologiczny Szpital Wolski im. dr Anny Gostyńskiej Samodzielny Publiczny Zakład Opieki Zdrowotnej | Warszawa, 01 - 211, Poland
Samodzielny Publiczny Centralny Szpital Kliniczny Akademii Medycznej w Warszawie | Warszawa, 02-097, Poland
II Klinika Choroby Wieńcowej Instytutu Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego | Warszawa, 02-637, Poland
Centrum Leczenia Chorób Cywilizacyjnych | Warszawa, 02-777, Poland
Międzyleski Szpital Specjalistyczny w Warszawie | Warszawa, 04-749, Poland
NZOZ Starówka | Warszawa, Poland
"Oddział Kardiologiczny Wałbrzyski Ośrodek Kardiologii Interwencyjnej Specjalityczny Szpital im. Dr Alfreda Sokołowskiego | Wałbrzych, 58-309, Poland
Osrodek Chorob Serca, Klinika Kardiologii 4 Wojskowy Szpital Kliniczny z Poliklinika - Samodzielny Publiczny Zaklad Opieki Zdrowotnej | Wroclaw, 50-981, Poland
Synexus SCM Sp.z o o. | Wrocław, 50-088, Poland
Niepubliczny Zakład Opieki Zdrowotnej, Centrum Badań Klinicznych | Wrocław, 50-349, Poland
"Śląskie Centrum Chorób Serca, III Katedra i Oddział Kliniczny Kardiologii Śląskiego Uniwersytetu Medycznego | Zabrze, 41-800, Poland
Oddział Kardiologiczny Szpital Wojewódzki im. Kardynała Stefana Wyszyńskiego | Łomża, 18-404, Poland
Niepubliczny Zakład Opieki Zdrowotnej POLIMEDICA | Łódź, 90-302, Poland
All-Med Centrum Medyczne | Łódź, 94-050, Poland
Research and Cardiovascular Corp. | Ponce, 00717-1322, Puerto Rico
Spitalul Clinic Judetean de Urgenta Bacau | Bacau, 600114, Romania
S.C. Duo Medical S.R.L. | Bucharest, 010584, Romania
Cardiomed SRL | Bucharest, 020506, Romania
Centrul Medical SANA | Bucuresti, 011025, Romania
Institutul Inimii "Niculae Stanicioiu" | Cluj-Napoca, 400001, Romania
Cardiomed SRL | Craiova, 200147, Romania
Dr. C.I. Parhon Hospital | Iasi, 700503, Romania
Clinical county Hospital | Sibiu, 550245, Romania
Institutul de Boli Cardiovasculare si Transplan Tg. Mures | Targu Mures, 540136, Romania
County Hospital | Timisoara, 300736, Romania
Novamed s.r.o. | Banská Bystrica, 97405, Slovakia
Alian s.r.o. | Bardejov, 085-01, Slovakia
5. Interna klinika LF UK, FNsP Bratislava, Nemocnica Ruzinov | Bratislava, 826 06, Slovakia
Cardio D&R spol. s r.o. | Kosice, 040-22, Slovakia
Kardiomed s.r.o. | Lučenec, 98401, Slovakia
NZZ Kardiocentrum Nitra s.r.o. | Nitra, 950-01, Slovakia
MUDr. Tibor DURIS, CSc., s.r.o. | Nove Zamky, 94052, Slovakia
Nemocnica s poliklinikou Považská Bystrica | Považská Bystrica, 017 26, Slovakia
Fakultna Nemocnica Trencin | Trencin, 911 71, Slovakia
Žilpo s.r.o. | Žilina, 010 01, Slovakia
Medivasa s.r.o. | Žilina, 010-01, Slovakia
"Klinichne obyednannia shvydkoi medychnoi dopomogy, m. Dnipropetrovs'k,Dnipropetrovs'ka derzhavna medychna akademiya, kafedra gospital'noi terapii #2 | Dnipropetrovsk, 49006, Ukraine
Oblasnyi klinichnyi kardiologichnyi dyspanser, m. Ivano-Frankivsk, Ivano-Frankivskyi derzhavnyi medychnyi universytet, kafedra terapii # 3 | Ivano-Frankivsk, 76005, Ukraine
TOV "Kardiologichna klinika "Sertse i sudyny" m. Kyiv | Kyiv, 1032, Ukraine
Natsionalnyi naukovyi tsentr "Instytut kardiologii im. akad. M.D. Strazheska" AMN Ukrainy, m. Kyiv, viddilenia symptomatychnykh arterial'nykh gipertenziy | Kyiv, 3680, Ukraine
Natsionalnyi naukovyi tsentr "Instytut kardiologii im. akad. M.D. Strazheska", viddil reanimatsii ta intensyvnoi terapii, m. Kyiv | Kyiv, 3680, Ukraine
Komunal'na ustanova "Oblasnyi kardiologichnyi dyspanser", viddilenia intensyvnoi terapii, m. Zaporizhzhia | Zaporizhzhya, 69000, Ukraine
Kardioarytmologichnyi tsentr Zhytomyrs'koi oblasnoi klinichnoi likarni im. O.F. Gorbachevs'kogo, m. Zhytomyr | Zhytomyr, 10002, Ukraine
Location Countries





Czech Republic







Puerto Rico




United States

Verification Date

January 2009

Responsible Party

Name Title: Pablo Lapuerta, MD

Organization: Cogentus Pharmaceuticals

Has Expanded Access No
Condition Browse
Number Of Arms 2
Arm Group

Label: 1

Type: Experimental

Label: 2

Type: Active Comparator

Acronym COGENT-1
Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Primary Purpose: Treatment

Masking: Triple (Participant, Investigator, Outcomes Assessor)