The Effects of Sorafenib on Molecular Barrett's Esophagus Cancer (Barrett's)

February 10, 2014 updated by: University of Chicago

A Pilot Study of the Effect of Sorafenib on Molecular Biomarkers in Barrett's Esophagus With High Grade Dysplasia

To determine whether sorafenib is able to change pre-cancerous cells in a way that we believe is important in the progression of cancer.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Detailed Description

To characterize the effects of sorafenib on specific molecular markers in patients with Barrett's esophagus and high grade intraepithelial neoplasia (HGIN) or carcinoma in situ (CIS).

Study Type

Interventional

Enrollment (Actual)

3

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Illinois
      • Chicago, Illinois, United States, 60637
        • University Of Chicago

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • ECOG performance status 0-2
  • Life expectancy of greater than 12 months
  • No prior history of esophageal surgery or endoscopic treatment of dysplasia
  • No prior exposure to sorafenib
  • Patients may not be receiving any other investigational agents or any concomitant antineoplastic therapy, with the exception of androgen ablating agents (for patients with prior prostate cancer)
  • Age 18 years.

  • Patients must have adequate organ and marrow function as defined below:

    • hemoglobin: 8.5 g/dL
    • absolute neutrophil count: 1,500/L
    • platelets: 100,000/L (greater than 35,000/L without transfusion for less than 1 X the institutional upper limit of normal)
    • creatinine less than 1.5 X institutional upper limit of normal
  • Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria:

  • A patient will be withdrawn from the study if any of the following events occur while on therapy:

    • Interruption of scheduled therapy for greater than 7 days
    • Intolerable adverse effects which are judged by the investigator to be either physically or psychologically detrimental to the patient
    • Patient decision to discontinue treatment
    • Pregnancy
    • Patient non-compliance with therapy administration
    • Grade 3 or 4 NCI-CTC toxicity attributable to sorafenib
    • Treatment with other chemotherapeutic or investigational anti-neoplastic drugs
    • Disease progression
  • HIV-positive patients receiving combination anti-retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with sorafenib.Appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicated.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Non-Randomized
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: sorafenib
sorafenib 2 tablets by mouth
Drug: sorafenib
2 tablets with water by mouth twice a day for two weeks.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Ki-67
Time Frame: Two weeks
Biomarker. Change in Ki-67 staining between pre- and on-therapy biopsies in patients with Barrett's esophagus.
Two weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Chicago

Collaborators

Bayer

Investigators

  • Principal Investigator: Ezra Cohen, MD, University Of Chicago

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2006

Primary Completion (Actual)

September 1, 2009

Study Completion (Actual)

September 1, 2009

Study Registration Dates

First Submitted

February 6, 2008

First Submitted That Met QC Criteria

February 19, 2008

First Posted (Estimate)

February 20, 2008

Study Record Updates

Last Update Posted (Estimate)

March 12, 2014

Last Update Submitted That Met QC Criteria

February 10, 2014

Last Verified

February 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 14374B

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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